Worm Phenotype (WP): larval lethal

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + + + 5: Variant [WBPhenotype:0000886] <2>

+ + + + 4: physiology variant [WBPhenotype:0000519] <14> (510|587) (510|248|68)

+ + + 3: development variant [WBPhenotype:0000518] <6> (508|585) (508|248|68)

+ + 2: organism development variant [WBPhenotype:0000531] <10> (505|583) (505|248|68)

+ 1: lethal [WBPhenotype:0000062] <5> (497|580) (497|247|68)

0: larval lethal [WBPhenotype:0000054] <4> (103|157) (104|77|23)

- 1: early larval lethal [WBPhenotype:0000057] <2> (3|3) (4|1|1)

- 1: late larval lethal [WBPhenotype:0000058] <2> (0|0) (0|0|0)

- 1: mid larval lethal [WBPhenotype:0000116] <2> (0|0) (0|0|0)

- 1: rod like larval lethal [WBPhenotype:0000411] (1|1) (1|0|0)

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Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Doublecortin (DC)	0	Direct
GAT-like domain	0	Direct
FF domain	0	Direct
ARID-like	0	Direct
Transducin (heterotrimeric G protein), gamma chain	0	Direct
Helical domain of Sec23/24	0	Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	Direct
Tubby C-terminal domain-like	0	Direct
Annexin	0	Direct
Phosphoenolpyruvate/pyruvate domain	0	Direct
FtsH protease domain-like	0	Direct
FAD-linked oxidases, C-terminal domain	0	Direct
SWIB/MDM2 domain	0	Direct
Formate/glycerate dehydrogenase catalytic domain-like	0	Direct
PK beta-barrel domain-like	0	Direct
eIF4e-like	0	Direct
Acid phosphatase/Vanadium-dependent haloperoxidase	0	Direct
Pepsin inhibitor-3	0	Direct
Pentein	0	Direct
Elafin-like	0	Direct
ArfGap/RecO-like zinc finger	0	Direct
Outer arm dynein light chain 1	0	Direct
MOSC N-terminal domain-like	0	Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	Direct
Proton glutamate symport protein	0	Direct
CO dehydrogenase molybdoprotein N-domain-like	0	Direct
C-terminal, gelsolin-like domain of Sec23/24	0	Direct
Fibrinogen C-terminal domain-like	0	Direct
WGR domain-like	0	Direct
Diaminopimelate epimerase-like	0	Direct
FAD-binding/transporter-associated domain-like	0	Direct
CO dehydrogenase ISP C-domain like	0	Direct
Rap/Ran-GAP	0	Direct
Carbohydrate phosphatase	0	Direct
Blood coagulation inhibitor (disintegrin)	0	Direct
LEM domain	0	Direct
MgtE membrane domain-like	0	Direct
ENTH/VHS domain	0	Direct
ADP-ribosylation	0	Direct
Terpenoid cyclases/Protein prenyltransferases	0	Direct
Hedgehog/intein (Hint) domain	0	Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	Direct
Nucleoside diphosphate kinase, NDK	0	Direct
Cdc48 domain 2-like	0	Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	Direct
Ran binding protein zinc finger-like	0	Direct
CBD9-like	0	Direct
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	Direct
Hormone receptor domain	0	Direct
DNA repair protein MutS, domain III	0	Direct
Heme-dependent catalase-like	0	Direct
Phoshotransferase/anion transport protein	0	Direct
14-3-3 protein	0	Direct
Complement control module/SCR domain	0	Direct
VPS9 domain	0	Direct
Cu,Zn superoxide dismutase-like	0	Direct
Oxysterol-binding protein-like	0	Direct
Cystatin/monellin	0	Direct
Bacterial exopeptidase dimerisation domain	0	Direct
Small-conductance potassium channel	0	Direct
GYF domain	0	Direct
LysM domain	0	Direct
Zn-finger domain of Sec23/24	0	Direct
Cadherin-like	0	Direct
PEBP-like	0	Direct
Molybdenum cofactor-binding domain	0	Direct
Composite domain of metallo-dependent hydrolases	0	Direct
MFPT repeat-like	0	Direct
ThrRS/AlaRS common domain	0	Direct
Creatinase/prolidase N-terminal domain	0	Direct
Ribokinase-like	0	Direct
PurM C-terminal domain-like	0	Direct
Protease propeptides/inhibitors	0	Direct
Transducin (alpha subunit), insertion domain	0	Direct
AN1-like Zinc finger	0	Direct
SPOC domain-like	0	Direct
Chitinase insertion domain	0	Direct
Glycolipid transfer protein, GLTP	0	Direct
Galactose oxidase, central domain	0	Direct
Heme-dependent peroxidases	0	Direct
SAND domain-like	0	Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	Direct
PEP carboxykinase N-terminal domain	0	Direct
Nucleoporin domain	0	Direct
PurM N-terminal domain-like	0	Direct
PABC (PABP) domain	0	Direct
HSP90 C-terminal domain	0	Direct
Restriction endonuclease-like	0	Direct
Domain of poly(ADP-ribose) polymerase	0	Direct
TGS-like	0	Direct
Sec7 domain	0	Direct
Hypothetical protein c14orf129, hspc210	0	Direct
GAS2 domain-like	0	Direct
Cation efflux protein cytoplasmic domain-like	0	Direct
PEP carboxykinase-like	0	Direct
PHM/PNGase F	0	Direct
Tricorn protease domain 2	0	Direct
R3H domain	0	Direct
PapD-like	0.00008177	Direct
Protein kinase-like (PK-like)	0.000944	Direct
Spectrin repeat	0.1122	Inherited
Homeodomain-like	0.2538	Inherited
Growth factor receptor domain	0.4019	Inherited

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Family

(show details)

SCOP term	FDR (all)	Annotation (direct or inherited)
Chitinase insertion domain	0	Direct
Pyk2-associated protein beta ARF-GAP domain	0	Direct
GAPDH-like	0	Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	Direct
Ras-binding domain, RBD	0	Direct
Myeloperoxidase-like	0	Direct
PDI-like	0	Direct
D-aminoacid oxidase-like	0	Direct
Ran binding protein zinc finger-like	0	Direct
PABC (PABP) domain	0	Direct
Transducin (alpha subunit), insertion domain	0	Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	Direct
DPP6 catalytic domain-like	0	Direct
Cell cycle control phosphatase, catalytic domain	0	Direct
Cdc48 domain 2-like	0	Direct
beta-sandwich domain of Sec23/24	0	Direct
Class I glutamine amidotransferases (GAT)	0	Direct
MOSC N-terminal domain-like	0	Direct
PEP carboxykinase C-terminal domain	0	Direct
Heat shock protein 90, HSP90, N-terminal domain	0	Direct
Laminin-type module	0	Direct
La domain	0	Direct
Pancreatic carboxypeptidase, activation domain	0	Direct
Inositol polyphosphate 5-phosphatase (IPP5)	0	Direct
Type II chitinase	0	Direct
Annexin	0	Direct
DNA repair protein MutS, domain III	0	Direct
Cytoplasmic domain of inward rectifier potassium channel	0	Direct
Heme-dependent catalases	0	Direct
Hydantoinase (dihydropyrimidinase)	0	Direct
RhoGDI-like	0	Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	Direct
WGR domain	0	Direct
Hydantoinase (dihydropyrimidinase), catalytic domain	0	Direct
Domain of poly(ADP-ribose) polymerase	0	Direct
SWIRM domain	0	Direct
First domain of FERM	0	Direct
FF domain	0	Direct
Ribokinase-like	0	Direct
Blood coagulation inhibitor (disintegrin)	0	Direct
DPP6 N-terminal domain-like	0	Direct
ATP-dependent protease Lon (La), catalytic domain	0	Direct
Acylamino-acid-releasing enzyme, C-terminal donain	0	Direct
Hsp90 middle domain	0	Direct
Proton glutamate symport protein	0	Direct
ARID domain	0	Direct
Cu,Zn superoxide dismutase-like	0	Direct
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	Direct
Small-conductance potassium channel	0	Direct
Helical domain of Sec23/24	0	Direct
28-residue LRR	0	Direct
XPF/Rad1/Mus81 nuclease	0	Direct
Sec63 N-terminal domain	0	Direct
PurM N-terminal domain-like	0	Direct
Fibrinogen C-terminal domain-like	0	Direct
Translation initiation factor eIF4e	0	Direct
Cofilin-like	0	Direct
Myotubularin-like phosphatases	0	Direct
Zn-finger domain of Sec23/24	0	Direct
COMT-like	0	Direct
Hexokinase	0	Direct
Poly(A) polymerase, PAP, middle domain	0	Direct
Tetraspanin	0	Direct
Doublecortin (DC)	0	Direct
Adenosine/AMP deaminase	0	Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	Direct
Glycolipid transfer protein, GLTP	0	Direct
Methionine aminopeptidase, insert domain	0	Direct
Vertebrate phospholipase A2	0	Direct
acyl-CoA oxidase C-terminal domains	0	Direct
Rap/Ran-GAP	0	Direct
GAS2 domain	0	Direct
Glycogenin	0	Direct
D-aminoacid oxidase, N-terminal domain	0	Direct
RNA-polymerase beta	0	Direct
Protein prenyltransferases	0	Direct
14-3-3 protein	0	Direct
Biotin dependent carboxylase carboxyltransferase domain	0	Direct
Calpain large subunit, catalytic domain (domain II)	0	Direct
Bacterial exopeptidase dimerisation domain	0	Direct
GYF domain	0	Direct
Epoxide hydrolase	0	Direct
Acireductone dioxygenase	0	Direct
PhzC/PhzF-like	0	Direct
LysM domain	0	Direct
Cadherin	0	Direct
MFPT repeat	0	Direct
Sec7 domain	0	Direct
Acyl-CoA thioesterase	0	Direct
Phoshoinositide 3-kinase (PI3K) helical domain	0	Direct
Pepsin inhibitor-3	0	Direct
Clathrin coat assembly domain	0	Direct
Paired domain	0	Direct
Poly(ADP-ribose) polymerase, C-terminal domain	0	Direct
HEAT repeat	0	Direct
Laminin G-like module	0	Direct
LEM domain	0	Direct
DEP domain	0	Direct
acyl-CoA oxidase N-terminal domains	0	Direct
L-aminoacid/polyamine oxidase	0	Direct
PEP carboxykinase N-terminal domain	0	Direct
Regulator of chromosome condensation RCC1	0	Direct
CO dehydrogenase molybdoprotein N-domain-like	0	Direct
1,3-glucuronyltransferase	0	Direct
LacY-like proton/sugar symporter	0	Direct
DEATH domain, DD	0	Direct
Trunk domain of Sec23/24	0	Direct
Transducin (heterotrimeric G protein), gamma chain	0	Direct
Inositol polyphosphate kinase (IPK)	0	Direct
Phosphatidylethanolamine binding protein	0	Direct
CO dehydrogenase flavoprotein N-terminal domain-like	0	Direct
Sec63 C-terminal domain-like	0	Direct
VHS domain	0	Direct
Serum paraoxonase/arylesterase 1, PON1	0	Direct
AMPK-beta glycogen binding domain-like	0	Direct
Nucleoside diphosphate kinase, NDK	0	Direct
Formate/glycerate dehydrogenases, NAD-domain	0	Direct
HSP90 C-terminal domain	0	Direct
FtsH protease domain-like	0	Direct
Molybdenum cofactor-binding domain	0	Direct
HCDH C-domain-like	0	Direct
SWIB/MDM2 domain	0	Direct
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	Direct
Choline kinase	0	Direct
Elafin-like	0	Direct
Cation efflux protein cytoplasmic domain-like	0	Direct
Glycerol kinase	0	Direct
Glutaminase	0	Direct
Bactericidal permeability-increasing protein, BPI	0	Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	Direct
Complement control module/SCR domain	0	Direct
Oxysterol-binding protein	0	Direct
Hedgehog C-terminal (Hog) autoprocessing domain	0	Direct
Arylsulfatase	0	Direct
YihX-like	0	Direct
CO dehydrogenase ISP C-domain like	0	Direct
Hypothetical protein c14orf129, hspc210	0	Direct
Glycerophosphoryl diester phosphodiesterase	0	Direct
SAM (sterile alpha motif) domain	0	Direct
AN1-like Zinc finger	0	Direct
Gamma-glutamyltranspeptidase-like	0	Direct
CoA-binding domain	0	Direct
Poly(A) polymerase, PAP, C-terminal domain	0	Direct
HD domain	0	Direct
SAND domain	0	Direct
Hormone receptor domain	0	Direct
NHL repeat	0	Direct
PurM C-terminal domain-like	0	Direct
Poly(A) polymerase, PAP, N-terminal domain	0	Direct
C-terminal, gelsolin-like domain of Sec23/24	0	Direct
Arfaptin, Rac-binding fragment	0	Direct
Arginine methyltransferase	0	Direct
MSP-like	0.0002047	Direct
Protein kinases, catalytic subunit	0.0004233	Direct
Spectrin repeat	0.1127	Inherited
Growth factor receptor domain	0.3907	Inherited
Homeodomain	0.4102	Inherited

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Supra-domain (including individual superfamily)

(show details)

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
ArfGap/RecO-like zinc finger	0	Direct
PEP carboxykinase-like	0	Direct
Epsilon subunit of mitochondrial F1F0-ATP synthase	0	Direct
Hypothetical protein c14orf129, hspc210	0	Direct
Elafin-like	0	Direct
Outer arm dynein light chain 1	0	Direct
MOSC N-terminal domain-like	0	Direct
Heme-dependent catalase-like	0	Direct
Oxysterol-binding protein-like	0	Direct
Bacterial exopeptidase dimerisation domain	0	Direct
Tubby C-terminal domain-like	0	Direct
Cystatin/monellin	0	Direct
Cdc48 domain 2-like	0	Direct
CO dehydrogenase molybdoprotein N-domain-like	0	Direct
C-terminal, gelsolin-like domain of Sec23/24	0	Direct
14-3-3 protein	0	Direct
ADP-ribosylation	0	Direct
Hedgehog/intein (Hint) domain	0	Direct
Proton glutamate symport protein	0	Direct
ARID-like	0	Direct
GAT-like domain	0	Direct
Hormone receptor domain	0	Direct
Annexin	0	Direct
Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)	0	Direct
LEM domain	0	Direct
Acid phosphatase/Vanadium-dependent haloperoxidase	0	Direct
PEP carboxykinase N-terminal domain	0	Direct
R3H domain	0	Direct
LysM domain	0	Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	Direct
CBD9-like	0	Direct
Diaminopimelate epimerase-like	0	Direct
Nucleoporin domain	0	Direct
DNA repair protein MutS, domain III	0	Direct
Glycolipid transfer protein, GLTP	0	Direct
Cation efflux protein cytoplasmic domain-like	0	Direct
Heme-dependent peroxidases	0	Direct
SWIB/MDM2 domain	0	Direct
Fibrinogen C-terminal domain-like	0	Direct
HSP90 C-terminal domain	0	Direct
Tricorn protease domain 2	0	Direct
Pepsin inhibitor-3	0	Direct
Cadherin-like	0	Direct
PurM N-terminal domain-like	0	Direct
VPS9 domain	0	Direct
ThrRS/AlaRS common domain	0	Direct
Complement control module/SCR domain	0	Direct
MFPT repeat-like	0	Direct
Galactose oxidase, central domain	0	Direct
Carbohydrate phosphatase	0	Direct
PHM/PNGase F	0	Direct
Helical domain of Sec23/24	0	Direct
FF domain	0	Direct
Blood coagulation inhibitor (disintegrin)	0	Direct
PK beta-barrel domain-like	0	Direct
Ran binding protein zinc finger-like	0	Direct
GAS2 domain-like	0	Direct
AN1-like Zinc finger	0	Direct
Transducin (alpha subunit), insertion domain	0	Direct
PurM C-terminal domain-like	0	Direct
Protease propeptides/inhibitors	0	Direct
PABC (PABP) domain	0	Direct
Transducin (heterotrimeric G protein), gamma chain	0	Direct
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	Direct
Restriction endonuclease-like	0	Direct
eIF4e-like	0	Direct
Rap/Ran-GAP	0	Direct
FtsH protease domain-like	0	Direct
Molybdenum cofactor-binding domain	0	Direct
SAND domain-like	0	Direct
ENTH/VHS domain	0	Direct
MgtE membrane domain-like	0	Direct
Pentein	0	Direct
Creatinase/prolidase N-terminal domain	0	Direct
TGS-like	0	Direct
Small-conductance potassium channel	0	Direct
Zn-finger domain of Sec23/24	0	Direct
Formate/glycerate dehydrogenase catalytic domain-like	0	Direct
Chitinase insertion domain	0	Direct
Doublecortin (DC)	0	Direct
CO dehydrogenase ISP C-domain like	0	Direct
GYF domain	0	Direct
Composite domain of metallo-dependent hydrolases	0	Direct
Phosphoenolpyruvate/pyruvate domain	0	Direct
SPOC domain-like	0	Direct
Ribokinase-like	0	Direct
WGR domain-like	0	Direct
FAD-linked oxidases, C-terminal domain	0	Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	Direct
Phoshotransferase/anion transport protein	0	Direct
Domain of poly(ADP-ribose) polymerase	0	Direct
FAD-binding/transporter-associated domain-like	0	Direct
Terpenoid cyclases/Protein prenyltransferases	0	Direct
PEBP-like	0	Direct
Sec7 domain	0	Direct
Nucleoside diphosphate kinase, NDK	0	Direct
Cu,Zn superoxide dismutase-like	0	Direct
PapD-like	0.00006694	Direct
Protein kinase-like (PK-like)	0.0007854	Direct
EGF/Laminin	0.0042	Inherited
Spectrin repeat	0.1016	Inherited
Homeodomain-like	0.2359	Inherited
Growth factor receptor domain	0.3813	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
81631,55003 81631 - PAP/OAS1 substrate-binding domain 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	Direct
56176,55103 56176 - FAD-binding/transporter-associated domain-like 55103 - FAD-linked oxidases, C-terminal domain	0	Direct
47473,51695 47473 - EF-hand 51695 - PLC-like phosphodiesterases	0	Direct
48425,50729 48425 - Sec7 domain 50729 - PH domain-like	0	Direct
51556,51338 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases	0	Direct
51971,54373 51971 - Nucleotide-binding domain 54373 - FAD-linked reductases, C-terminal domain	0	Direct
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0	Direct
48464,89009 48464 - ENTH/VHS domain 89009 - GAT-like domain	0	Direct
81324,53850 81324 - Voltage-gated potassium channels 53850 - Periplasmic binding protein-like II	0	Direct
47741,56176 47741 - CO dehydrogenase ISP C-domain like 56176 - FAD-binding/transporter-associated domain-like	0	Direct
54897,53187 54897 - Protease propeptides/inhibitors 53187 - Zn-dependent exopeptidases	0	Direct
81383,52047 81383 - F-box domain 52047 - RNI-like	0	Direct
54495,46934 54495 - UBC-like 46934 - UBA-like	0	Direct
54665,56003 54665 - CO dehydrogenase molybdoprotein N-domain-like 56003 - Molybdenum cofactor-binding domain	0	Direct
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0	Direct
54211,55060 54211 - Ribosomal protein S5 domain 2-like 55060 - GHMP Kinase, C-terminal domain	0	Direct
54897,52743 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like	0	Direct
52540,90123 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region	0	Direct
49742,49742 49742 - PHM/PNGase F 49742 - PHM/PNGase F	0	Direct
51338,51556 51338 - Composite domain of metallo-dependent hydrolases 51556 - Metallo-dependent hydrolases	0	Direct
81383,50978 81383 - F-box domain 50978 - WD40 repeat-like	0	Direct
57184,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0	Direct
81811,82754 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24	0	Direct
50978,50998 50978 - WD40 repeat-like 50998 - Quinoprotein alcohol dehydrogenase-like	0	Direct
56601,48403 56601 - beta-lactamase/transpeptidase-like 48403 - Ankyrin repeat	0	Direct
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin	0	Direct
57414,57414 57414 - Hairpin loop containing domain-like 57414 - Hairpin loop containing domain-like	0	Direct
81324,81296 81324 - Voltage-gated potassium channels 81296 - E set domains	0	Direct
144232,82199 144232 - HIT/MYND zinc finger-like 82199 - SET domain	0	Direct
68923,53795 68923 - PEP carboxykinase N-terminal domain 53795 - PEP carboxykinase-like	0	Direct
81324,81327 81324 - Voltage-gated potassium channels 81327 - Small-conductance potassium channel	0	Direct
47587,56399 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation	0	Direct
52283,51735 52283 - Formate/glycerate dehydrogenase catalytic domain-like 51735 - NAD(P)-binding Rossmann-fold domains	0	Direct
50156,50044 50156 - PDZ domain-like 50044 - SH3-domain	0	Direct
47203,47203 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0	Direct
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat	0	Direct
53187,55031 53187 - Zn-dependent exopeptidases 55031 - Bacterial exopeptidase dimerisation domain	0	Direct
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0	Direct
55920,46785 55920 - Creatinase/aminopeptidase 46785 - "Winged helix" DNA-binding domain	0	Direct
55326,56042 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like	0	Direct
48334,52540 48334 - DNA repair protein MutS, domain III 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
54534,54534 54534 - FKBP-like 54534 - FKBP-like	0	Direct
141739,141739 141739 - MFPT repeat-like 141739 - MFPT repeat-like	0	Direct
47473,103506 47473 - EF-hand 103506 - Mitochondrial carrier	0	Direct
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like	0	Direct
57196,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases	0	Direct
81698,81698 81698 - FF domain 81698 - FF domain	0	Direct
51445,54556 51445 - (Trans)glycosidases 54556 - Chitinase insertion domain	0	Direct
54001,49758 54001 - Cysteine proteinases 49758 - Calpain large subunit, middle domain (domain III)	0	Direct
50044,52540 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
161093,161093 161093 - MgtE membrane domain-like 161093 - MgtE membrane domain-like	0	Direct
55394,55394 55394 - Bactericidal permeability-increasing protein, BPI 55394 - Bactericidal permeability-increasing protein, BPI	0	Direct
57903,51197 57903 - FYVE/PHD zinc finger 51197 - Clavaminate synthase-like	0	Direct
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
56112,48371 56112 - Protein kinase-like (PK-like) 48371 - ARM repeat	0	Direct
52113,52113 52113 - BRCT domain 52113 - BRCT domain	0	Direct
47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain	0	Direct
57903,82199 57903 - FYVE/PHD zinc finger 82199 - SET domain	0	Direct
46785,46785 46785 - "Winged helix" DNA-binding domain 46785 - "Winged helix" DNA-binding domain	0	Direct
52540,140990 52540 - P-loop containing nucleoside triphosphate hydrolases 140990 - FtsH protease domain-like	0	Direct
57850,117839 57850 - RING/U-box 117839 - WWE domain	0	Direct
48403,52151 48403 - Ankyrin repeat 52151 - FabD/lysophospholipase-like	0	Direct
52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain	0	Direct
48179,48179 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like	0	Direct
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
141673,50800 141673 - MOSC N-terminal domain-like 50800 - PK beta-barrel domain-like	0	Direct
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like	0	Direct
161111,160240 161111 - Cation efflux protein transmembrane domain-like 160240 - Cation efflux protein cytoplasmic domain-like	0	Direct
52540,81271 52540 - P-loop containing nucleoside triphosphate hydrolases 81271 - TGS-like	0	Direct
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like	0	Direct
64356,49447 64356 - SNARE-like 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	Direct
57863,48403 57863 - ArfGap/RecO-like zinc finger 48403 - Ankyrin repeat	0	Direct
55486,57552 55486 - Metalloproteases ("zincins"), catalytic domain 57552 - Blood coagulation inhibitor (disintegrin)	0	Direct
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0	Direct
54292,47741 54292 - 2Fe-2S ferredoxin-like 47741 - CO dehydrogenase ISP C-domain like	0	Direct
56436,56436 56436 - C-type lectin-like 56436 - C-type lectin-like	0.0007973	Direct
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat	0.2518	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
56436,49854,49854 56436 - C-type lectin-like 49854 - Spermadhesin, CUB domain 49854 - Spermadhesin, CUB domain	0	Direct
51735,48179,48179 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like	0	Direct
81301,81631,55003 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	Direct
57535,57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0	Direct
46938,52087,101576 46938 - CRAL/TRIO N-terminal domain 52087 - CRAL/TRIO domain 101576 - Supernatant protein factor (SPF), C-terminal domain	0	Direct
90123,52540,90123 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region	0	Direct
57414,57414,57414 57414 - Hairpin loop containing domain-like 57414 - Hairpin loop containing domain-like 57414 - Hairpin loop containing domain-like	0	Direct
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0	Direct
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0	Direct
52540,90123,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
50156,50044,52540 50156 - PDZ domain-like 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like	0	Direct
47090,55486,50923 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0	Direct
50729,47473,51695 50729 - PH domain-like 47473 - EF-hand 51695 - PLC-like phosphodiesterases	0	Direct
54292,47741,56176 54292 - 2Fe-2S ferredoxin-like 47741 - CO dehydrogenase ISP C-domain like 56176 - FAD-binding/transporter-associated domain-like	0	Direct
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
56645,47203,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0	Direct
48726,49265,48726 48726 - Immunoglobulin 49265 - Fibronectin type III 48726 - Immunoglobulin	0	Direct
57567,57567,57567 57567 - Serine protease inhibitors 57567 - Serine protease inhibitors 57567 - Serine protease inhibitors	0	Direct
54897,52743,49785 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like 49785 - Galactose-binding domain-like	0	Direct
50044,50044,50044 50044 - SH3-domain 50044 - SH3-domain 50044 - SH3-domain	0	Direct
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat	0.3144	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Worm Phenotype (WP): larval lethal

Superfamily

Family

Supra-domain (including individual superfamily)