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Worm Phenotype (WP): organism stress response variant
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this WP term (SDWP level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| HRDC-like | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0000001124 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.00000094 | DIRECT |
| GST C-terminal domain-like | 0.00002064 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.00003196 | DIRECT |
| PIN domain-like | 0.00003257 | DIRECT |
| Thioredoxin-like | 0.00004031 | DIRECT |
| F1F0 ATP synthase subunit C | 0.0002054 | DIRECT |
| ARID-like | 0.0002054 | DIRECT |
| Aquaporin-like | 0.0003418 | DIRECT |
| Class II aaRS ABD-related | 0.0006112 | DIRECT |
| Cysteine-rich domain | 0.0009123 | DIRECT |
| Di-copper centre-containing domain | 0.001003 | INHERITED FROM: cell ionizing radiation response variant || organism ionizing radiation response variant || cell stress response variant || germ cell ionizing radiation response variant |
| PLC-like phosphodiesterases | 0.002891 | INHERITED FROM: response to injury variant || cellular osmotic stress response variant || organism pathogen response variant || cell stress response variant || organism osmotic stress response variant |
| NAD kinase/diacylglycerol kinase-like | 0.003196 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
| Class II aaRS and biotin synthetases | 0.003783 | INHERITED FROM: hypoxia response variant || hypoxia resistant |
| Saposin | 0.004527 | INHERITED FROM: pathogen load variant || radiation induced germ cell apoptosis variant || increased pathogen survival || germ cell ionizing radiation response variant || germ cell resistant ionizing radiation |
| PH domain-like | 0.005304 | INHERITED FROM: bacterially unswollen || response to injury variant || cellular osmotic stress response variant || organism pathogen response variant || pathogen resistance increased |
| Nucleotidylyl transferase | 0.008941 | INHERITED FROM: hypoxia response variant || paraquat resistant || hypoxia resistant |
| HSP20-like chaperones | 0.009603 | INHERITED FROM: pathogen susceptibility increased |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.01269 | INHERITED FROM: organism oxidative stress response variant || paraquat response variant |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.0241 | INHERITED FROM: hypoxia response variant || hypoxia resistant |
| ACP-like | 0.02458 | INHERITED FROM: organism starvation response variant |
| DBL homology domain (DH-domain) | 0.02994 | INHERITED FROM: bacterially unswollen || organism pathogen response variant || pathogen resistance increased |
| GroEL-intermediate domain like | 0.03807 | INHERITED FROM: unfolded protein response variant || innate immune response variant || organism temperature response variant || cell stress response variant || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant |
| GroEL equatorial domain-like | 0.03807 | INHERITED FROM: unfolded protein response variant || innate immune response variant || organism temperature response variant || cell stress response variant || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant |
| GroEL apical domain-like | 0.03807 | INHERITED FROM: unfolded protein response variant || innate immune response variant || organism temperature response variant || cell stress response variant || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant |
| Multidrug resistance efflux transporter EmrE | 0.04393 | INHERITED FROM: bacterially unswollen || pathogen resistance increased |
| Bromodomain | 0.05978 | INHERITED FROM: organism UV response variant || organism UV hypersensitive |
| Hect, E3 ligase catalytic domain | 0.09343 | INHERITED FROM: cell ionizing radiation response variant || germ cell ionizing radiation response variant |
| RING/U-box | 0.1053 | INHERITED FROM: cell ionizing radiation response variant || organism ionizing radiation response variant || germ cell hypersensitive ionizing radiation || cell stress response variant || germ cell ionizing radiation response variant |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.1101 | INHERITED FROM: response to injury variant || cellular osmotic stress response variant || cell stress response variant || organism osmotic stress response variant || pathogen induced antimicrobial gene expression variant |
| Chromo domain-like | 0.1129 | INHERITED FROM: organism UV response variant || organism UV hypersensitive |
| Ankyrin repeat | 0.1164 | INHERITED FROM: organism heat response variant |
| Periplasmic binding protein-like II | 0.1351 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant || organism starvation response variant |
| Heme-dependent peroxidases | 0.1453 | INHERITED FROM: pathogen susceptibility increased |
| HD-domain/PDEase-like | 0.1453 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant || organism temperature response variant |
| Histone-fold | 0.1801 | INHERITED FROM: innate immune response variant || stress induced lethality variant || organism hypertonic lethality increased || organism pathogen response variant || pathogen induced gene expression variant || stress induced lethality increased || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant |
| (Trans)glycosidases | 0.2121 | INHERITED FROM: pathogen susceptibility increased |
| Arginase/deacetylase | 0.2239 | INHERITED FROM: organism UV response variant || organism UV hypersensitive |
| PYP-like sensor domain (PAS domain) | 0.2239 | INHERITED FROM: hypoxia hypersensitive || hypoxia response variant |
| DEATH domain | 0.2666 | INHERITED FROM: pathogen susceptibility increased || organism pathogen response variant |
| DNA/RNA polymerases | 0.2666 | INHERITED FROM: organism UV response variant || organism UV hypersensitive |
| RNA-binding domain, RBD | 0.2794 | INHERITED FROM: innate immune response variant || starvation induced apoptosis variant || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.2833 | INHERITED FROM: stress induced lethality variant || organism hypertonic lethality increased || stress induced lethality increased || organism osmotic stress response variant |
| Nucleic acid-binding proteins | 0.3098 | INHERITED FROM: hypoxia resistant |
| FAD/NAD(P)-binding domain | 0.3181 | INHERITED FROM: organism oxidative stress response variant |
| Leucine zipper domain | 0.3586 | INHERITED FROM: pathogen susceptibility increased |
| Quinoprotein alcohol dehydrogenase-like | 0.3653 | INHERITED FROM: hypoxia response variant |
| Sm-like ribonucleoproteins | 0.3653 | INHERITED FROM: unfolded protein response variant || organism heat response variant |
| FYVE/PHD zinc finger | 0.3785 | INHERITED FROM: organism UV response variant || organism UV hypersensitive |
| PLP-dependent transferases | 0.4248 | INHERITED FROM: radiation induced germ cell apoptosis variant || germ cell resistant ionizing radiation |
| Lipocalins | 0.4654 | INHERITED FROM: paraquat hypersensitive |
| cAMP-binding domain-like | 0.4654 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant || organism temperature response variant |
| Insulin-like | 0.6007 | INHERITED FROM: temperature induced dauer formation variant |
| WD40 repeat-like | 0.7164 | INHERITED FROM: pathogen induced antimicrobial gene expression variant |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.7466 | INHERITED FROM: cell gamma ray response variant || gamma ray induced apoptosis increased || organism gamma ray response variant |
| HLH, helix-loop-helix DNA-binding domain | 0.8468 | INHERITED FROM: fungal resistance increased || hypoxia response variant || pathogen resistance increased |
| Metallo-dependent phosphatases | 0.8694 | INHERITED FROM: radiation induced germ cell apoptosis variant || germ cell resistant ionizing radiation |
| Cysteine proteinases | 0.9585 | INHERITED FROM: paraquat hypersensitive |
| Protein kinase-like (PK-like) | 0.972 | INHERITED FROM: anoxia resistant || organism oxidative stress response variant || hypoxia response variant || organism osmotic stress hypersensitive |
| Periplasmic binding protein-like I | 0.9866 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant || organism temperature response variant |
| P-loop containing nucleoside triphosphate hydrolases | 0.9922 | INHERITED FROM: organism hypersensitive ionizing radiation || organism UV response variant || pathogen release variant |
| Nicotinic receptor ligand binding domain-like | 1 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
| EF-hand | 1 | INHERITED FROM: cellular osmotic stress response variant |
| Neurotransmitter-gated ion-channel transmembrane pore | 1 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
| MFS general substrate transporter | 1 | INHERITED FROM: organism high sodium chloride hypersensitive |
| Nucleotide cyclase | 1 | INHERITED FROM: thermotaxis variant |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| HRDC-like | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0000001124 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.00000094 | Direct |
| GST C-terminal domain-like | 0.00002064 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.00003196 | Direct |
| PIN domain-like | 0.00003257 | Direct |
| Thioredoxin-like | 0.00004031 | Direct |
| F1F0 ATP synthase subunit C | 0.0002054 | Direct |
| ARID-like | 0.0002054 | Direct |
| Aquaporin-like | 0.0003418 | Direct |
| Class II aaRS ABD-related | 0.0006112 | Direct |
| Cysteine-rich domain | 0.0009123 | Direct |
| Di-copper centre-containing domain | 0.001003 | Inherited |
| PLC-like phosphodiesterases | 0.002891 | Inherited |
| NAD kinase/diacylglycerol kinase-like | 0.003196 | Inherited |
| Class II aaRS and biotin synthetases | 0.003783 | Inherited |
| Saposin | 0.004527 | Inherited |
| PH domain-like | 0.005304 | Inherited |
| Nucleotidylyl transferase | 0.008941 | Inherited |
| HSP20-like chaperones | 0.009603 | Inherited |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.01269 | Inherited |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.0241 | Inherited |
| ACP-like | 0.02458 | Inherited |
| DBL homology domain (DH-domain) | 0.02994 | Inherited |
| GroEL-intermediate domain like | 0.03807 | Inherited |
| GroEL equatorial domain-like | 0.03807 | Inherited |
| GroEL apical domain-like | 0.03807 | Inherited |
| Multidrug resistance efflux transporter EmrE | 0.04393 | Inherited |
| Bromodomain | 0.05978 | Inherited |
| Hect, E3 ligase catalytic domain | 0.09343 | Inherited |
| RING/U-box | 0.1053 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.1101 | Inherited |
| Chromo domain-like | 0.1129 | Inherited |
| Ankyrin repeat | 0.1164 | Inherited |
| Periplasmic binding protein-like II | 0.1351 | Inherited |
| Heme-dependent peroxidases | 0.1453 | Inherited |
| HD-domain/PDEase-like | 0.1453 | Inherited |
| Histone-fold | 0.1801 | Inherited |
| (Trans)glycosidases | 0.2121 | Inherited |
| Arginase/deacetylase | 0.2239 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.2239 | Inherited |
| DEATH domain | 0.2666 | Inherited |
| DNA/RNA polymerases | 0.2666 | Inherited |
| RNA-binding domain, RBD | 0.2794 | Inherited |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.2833 | Inherited |
| Nucleic acid-binding proteins | 0.3098 | Inherited |
| FAD/NAD(P)-binding domain | 0.3181 | Inherited |
| Leucine zipper domain | 0.3586 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.3653 | Inherited |
| Sm-like ribonucleoproteins | 0.3653 | Inherited |
| FYVE/PHD zinc finger | 0.3785 | Inherited |
| PLP-dependent transferases | 0.4248 | Inherited |
| Lipocalins | 0.4654 | Inherited |
| cAMP-binding domain-like | 0.4654 | Inherited |
| Insulin-like | 0.6007 | Inherited |
| WD40 repeat-like | 0.7164 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.7466 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.8468 | Inherited |
| Metallo-dependent phosphatases | 0.8694 | Inherited |
| Cysteine proteinases | 0.9585 | Inherited |
| Protein kinase-like (PK-like) | 0.972 | Inherited |
| Periplasmic binding protein-like I | 0.9866 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 0.9922 | Inherited |
| Nicotinic receptor ligand binding domain-like | 1 | Inherited |
| EF-hand | 1 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 1 | Inherited |
| MFS general substrate transporter | 1 | Inherited |
| Nucleotide cyclase | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this WP term (SDWP level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Heme-dependent catalases | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| RNA-polymerase beta | 0 | DIRECT |
| Mammalian PLC | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| 5' to 3' exonuclease catalytic domain | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| Arginine methyltransferase | 0 | DIRECT |
| PLC-like (P variant) | 0.0000005456 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00000195 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.000002817 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.000002817 | DIRECT |
| Tandem AAA-ATPase domain | 0.000003027 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.00001429 | DIRECT |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.00002907 | DIRECT |
| Aquaporin-like | 0.00007139 | DIRECT |
| Erythroid transcription factor GATA-1 | 0.0002622 | DIRECT |
| ARID domain | 0.000338 | DIRECT |
| F1F0 ATP synthase subunit C | 0.000338 | DIRECT |
| Glutathione S-transferase (GST), C-terminal domain | 0.0005923 | DIRECT |
| Glutathione S-transferase (GST), N-terminal domain | 0.0009014 | DIRECT |
| Hemocyanin middle domain | 0.001837 | INHERITED FROM: cell ionizing radiation response variant || organism ionizing radiation response variant || cell stress response variant || germ cell ionizing radiation response variant |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.002648 | INHERITED FROM: hypoxia response variant || hypoxia resistant |
| Pleckstrin-homology domain (PH domain) | 0.009697 | INHERITED FROM: bacterially unswollen || cellular osmotic stress response variant || organism pathogen response variant || cell stress response variant || pathogen resistance increased |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.00976 | INHERITED FROM: hypoxia response variant || paraquat resistant || hypoxia resistant || paraquat response variant |
| HSP20 | 0.01018 | INHERITED FROM: pathogen susceptibility increased || organism pathogen response variant |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.0181 | INHERITED FROM: organism oxidative stress response variant || paraquat response variant |
| DBL homology domain (DH-domain) | 0.02267 | INHERITED FROM: bacterially unswollen || organism pathogen response variant || pathogen resistance increased |
| Group II chaperonin (CCT, TRIC), apical domain | 0.04798 | INHERITED FROM: unfolded protein response variant || innate immune response variant || organism heat response variant || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant |
| Bromodomain | 0.04798 | INHERITED FROM: organism UV response variant || organism UV hypersensitive |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.04798 | INHERITED FROM: unfolded protein response variant || innate immune response variant || organism heat response variant || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant |
| RING finger domain, C3HC4 | 0.06108 | INHERITED FROM: germ cell hypersensitive ionizing radiation || germ cell ionizing radiation response variant |
| Rhodopsin-like | 0.0695 | INHERITED FROM: organism pathogen response variant |
| Hect, E3 ligase catalytic domain | 0.07677 | INHERITED FROM: cell ionizing radiation response variant || germ cell ionizing radiation response variant |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.07677 | INHERITED FROM: organism oxidative stress response variant || paraquat response variant |
| Fatty acid binding protein-like | 0.07677 | INHERITED FROM: paraquat hypersensitive || paraquat response variant |
| Armadillo repeat | 0.07677 | INHERITED FROM: innate immune response variant || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant |
| Ankyrin repeat | 0.0912 | INHERITED FROM: organism heat response variant |
| Phosphate binding protein-like | 0.1118 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant || organism starvation response variant |
| Myeloperoxidase-like | 0.1223 | INHERITED FROM: pathogen susceptibility increased |
| PDEase | 0.1223 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant || organism temperature response variant |
| Nucleosome core histones | 0.15 | INHERITED FROM: innate immune response variant || stress induced lethality variant || organism hypertonic lethality increased || organism pathogen response variant || pathogen induced gene expression variant || stress induced lethality increased || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant |
| Glutathione peroxidase-like | 0.1605 | INHERITED FROM: paraquat hypersensitive || paraquat response variant |
| PHD domain | 0.1866 | INHERITED FROM: organism UV response variant || organism UV hypersensitive |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0.1946 | INHERITED FROM: unfolded protein response variant || organism temperature response variant || cell stress response variant || organism heat response variant |
| Histone deacetylase, HDAC | 0.1946 | INHERITED FROM: organism UV response variant || organism UV hypersensitive |
| EF-hand modules in multidomain proteins | 0.1946 | INHERITED FROM: cell stress response variant |
| Chromo domain | 0.2513 | INHERITED FROM: organism UV response variant || organism UV hypersensitive |
| Canonical RBD | 0.2778 | INHERITED FROM: innate immune response variant || starvation induced apoptosis variant || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant |
| Proteasome subunits | 0.3166 | INHERITED FROM: stress induced lethality variant || organism hypertonic lethality increased || stress induced lethality increased || organism osmotic stress response variant || no induction of antimicrobial peptide expression after infection |
| Leucine zipper domain | 0.3166 | INHERITED FROM: pathogen susceptibility increased |
| cAMP-binding domain | 0.4237 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant || organism temperature response variant |
| WD40-repeat | 0.4442 | INHERITED FROM: pathogen induced antimicrobial gene expression variant |
| Insulin-like | 0.5559 | INHERITED FROM: temperature induced dauer formation variant |
| HLH, helix-loop-helix DNA-binding domain | 0.8101 | INHERITED FROM: fungal resistance increased || pathogen resistance increased |
| Protein kinases, catalytic subunit | 0.9343 | INHERITED FROM: anoxia resistant || hypoxia response variant || anoxia response variant |
| Nicotinic receptor ligand binding domain-like | 1 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
| L-arabinose binding protein-like | 1 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant || organism temperature response variant |
| G proteins | 1 | INHERITED FROM: cellular osmotic stress response variant || pathogen release variant |
| Neurotransmitter-gated ion-channel transmembrane pore | 1 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Heme-dependent catalases | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| RNA-polymerase beta | 0 | Direct |
| Mammalian PLC | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| 5' to 3' exonuclease catalytic domain | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| Arginine methyltransferase | 0 | Direct |
| PLC-like (P variant) | 0.0000005456 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00000195 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.000002817 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.000002817 | Direct |
| Tandem AAA-ATPase domain | 0.000003027 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.00001429 | Direct |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.00002907 | Direct |
| Aquaporin-like | 0.00007139 | Direct |
| Erythroid transcription factor GATA-1 | 0.0002622 | Direct |
| ARID domain | 0.000338 | Direct |
| F1F0 ATP synthase subunit C | 0.000338 | Direct |
| Glutathione S-transferase (GST), C-terminal domain | 0.0005923 | Direct |
| Glutathione S-transferase (GST), N-terminal domain | 0.0009014 | Direct |
| Hemocyanin middle domain | 0.001837 | Inherited |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.002648 | Inherited |
| Pleckstrin-homology domain (PH domain) | 0.009697 | Inherited |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.00976 | Inherited |
| HSP20 | 0.01018 | Inherited |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.0181 | Inherited |
| DBL homology domain (DH-domain) | 0.02267 | Inherited |
| Group II chaperonin (CCT, TRIC), apical domain | 0.04798 | Inherited |
| Bromodomain | 0.04798 | Inherited |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.04798 | Inherited |
| RING finger domain, C3HC4 | 0.06108 | Inherited |
| Rhodopsin-like | 0.0695 | Inherited |
| Hect, E3 ligase catalytic domain | 0.07677 | Inherited |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.07677 | Inherited |
| Fatty acid binding protein-like | 0.07677 | Inherited |
| Armadillo repeat | 0.07677 | Inherited |
| Ankyrin repeat | 0.0912 | Inherited |
| Phosphate binding protein-like | 0.1118 | Inherited |
| Myeloperoxidase-like | 0.1223 | Inherited |
| PDEase | 0.1223 | Inherited |
| Nucleosome core histones | 0.15 | Inherited |
| Glutathione peroxidase-like | 0.1605 | Inherited |
| PHD domain | 0.1866 | Inherited |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0.1946 | Inherited |
| Histone deacetylase, HDAC | 0.1946 | Inherited |
| EF-hand modules in multidomain proteins | 0.1946 | Inherited |
| Chromo domain | 0.2513 | Inherited |
| Canonical RBD | 0.2778 | Inherited |
| Proteasome subunits | 0.3166 | Inherited |
| Leucine zipper domain | 0.3166 | Inherited |
| cAMP-binding domain | 0.4237 | Inherited |
| WD40-repeat | 0.4442 | Inherited |
| Insulin-like | 0.5559 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.8101 | Inherited |
| Protein kinases, catalytic subunit | 0.9343 | Inherited |
| Nicotinic receptor ligand binding domain-like | 1 | Inherited |
| L-arabinose binding protein-like | 1 | Inherited |
| G proteins | 1 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this WP term (SPWP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| HRDC-like | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00000009003 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.0000007594 | DIRECT |
| GST C-terminal domain-like | 0.00001682 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.00002609 | DIRECT |
| PIN domain-like | 0.00002659 | DIRECT |
| Thioredoxin-like | 0.00003294 | DIRECT |
| F1F0 ATP synthase subunit C | 0.0001688 | DIRECT |
| ARID-like | 0.0001688 | DIRECT |
| Aquaporin-like | 0.0002817 | DIRECT |
| Class II aaRS ABD-related | 0.0005064 | DIRECT |
| Cysteine-rich domain | 0.000759 | DIRECT |
| Di-copper centre-containing domain | 0.0008351 | DIRECT |
| PLC-like phosphodiesterases | 0.002439 | INHERITED FROM: organism osmotic stress response variant || organism pathogen response variant || cell stress response variant || response to injury variant || cellular osmotic stress response variant |
| NAD kinase/diacylglycerol kinase-like | 0.002699 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
| Class II aaRS and biotin synthetases | 0.003205 | INHERITED FROM: hypoxia resistant || hypoxia response variant |
| Saposin | 0.003843 | INHERITED FROM: radiation induced germ cell apoptosis variant || germ cell resistant ionizing radiation || germ cell ionizing radiation response variant || pathogen load variant || increased pathogen survival |
| PH domain-like | 0.004509 | INHERITED FROM: organism pathogen response variant || response to injury variant || cellular osmotic stress response variant || pathogen resistance increased || bacterially unswollen |
| Nucleotidylyl transferase | 0.007673 | INHERITED FROM: hypoxia resistant || hypoxia response variant || paraquat resistant |
| HSP20-like chaperones | 0.008252 | INHERITED FROM: pathogen susceptibility increased |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.01096 | INHERITED FROM: paraquat response variant || organism oxidative stress response variant |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.02105 | INHERITED FROM: hypoxia resistant || hypoxia response variant |
| ACP-like | 0.02149 | INHERITED FROM: organism starvation response variant |
| DBL homology domain (DH-domain) | 0.02629 | INHERITED FROM: organism pathogen response variant || pathogen resistance increased || bacterially unswollen |
| GroEL equatorial domain-like | 0.03356 | INHERITED FROM: pathogen induced antimicrobial gene expression variant || no induction of antimicrobial peptide expression after infection || cell stress response variant || organism temperature response variant || unfolded protein response variant || innate immune response variant |
| GroEL apical domain-like | 0.03356 | INHERITED FROM: pathogen induced antimicrobial gene expression variant || no induction of antimicrobial peptide expression after infection || cell stress response variant || organism temperature response variant || unfolded protein response variant || innate immune response variant |
| GroEL-intermediate domain like | 0.03356 | INHERITED FROM: pathogen induced antimicrobial gene expression variant || no induction of antimicrobial peptide expression after infection || cell stress response variant || organism temperature response variant || unfolded protein response variant || innate immune response variant |
| Multidrug resistance efflux transporter EmrE | 0.03881 | INHERITED FROM: pathogen resistance increased || bacterially unswollen |
| Bromodomain | 0.05322 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
| Hect, E3 ligase catalytic domain | 0.08419 | INHERITED FROM: cell ionizing radiation response variant || germ cell ionizing radiation response variant |
| RING/U-box | 0.09519 | INHERITED FROM: germ cell hypersensitive ionizing radiation || cell stress response variant || cell ionizing radiation response variant || organism ionizing radiation response variant || germ cell ionizing radiation response variant |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.09966 | INHERITED FROM: pathogen induced antimicrobial gene expression variant || organism osmotic stress response variant || cell stress response variant || response to injury variant || cellular osmotic stress response variant |
| Chromo domain-like | 0.1022 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
| Ankyrin repeat | 0.1056 | INHERITED FROM: organism heat response variant |
| Periplasmic binding protein-like II | 0.123 | INHERITED FROM: thermosensory behavior variant || organism starvation response variant || thermotaxis variant |
| Heme-dependent peroxidases | 0.1325 | INHERITED FROM: pathogen susceptibility increased |
| HD-domain/PDEase-like | 0.1325 | INHERITED FROM: thermosensory behavior variant || organism temperature response variant || thermotaxis variant |
| Histone-fold | 0.1654 | INHERITED FROM: pathogen induced antimicrobial gene expression variant || no induction of antimicrobial peptide expression after infection || organism pathogen response variant || pathogen induced gene expression variant || organism hypertonic lethality increased || stress induced lethality variant || stress induced lethality increased || innate immune response variant |
| (Trans)glycosidases | 0.1958 | INHERITED FROM: pathogen susceptibility increased |
| PYP-like sensor domain (PAS domain) | 0.207 | INHERITED FROM: hypoxia hypersensitive || hypoxia response variant |
| Arginase/deacetylase | 0.207 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
| DNA/RNA polymerases | 0.2485 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
| DEATH domain | 0.2485 | INHERITED FROM: pathogen susceptibility increased || organism pathogen response variant |
| RNA-binding domain, RBD | 0.2608 | INHERITED FROM: pathogen induced antimicrobial gene expression variant || no induction of antimicrobial peptide expression after infection || starvation induced apoptosis variant || innate immune response variant |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.2647 | INHERITED FROM: organism osmotic stress response variant || organism hypertonic lethality increased || stress induced lethality variant || stress induced lethality increased |
| Nucleic acid-binding proteins | 0.2904 | INHERITED FROM: hypoxia resistant |
| FAD/NAD(P)-binding domain | 0.2986 | INHERITED FROM: organism oxidative stress response variant |
| Leucine zipper domain | 0.3383 | INHERITED FROM: pathogen susceptibility increased |
| Quinoprotein alcohol dehydrogenase-like | 0.345 | INHERITED FROM: hypoxia response variant |
| Sm-like ribonucleoproteins | 0.345 | INHERITED FROM: organism heat response variant || unfolded protein response variant |
| FYVE/PHD zinc finger | 0.358 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
| PLP-dependent transferases | 0.404 | INHERITED FROM: radiation induced germ cell apoptosis variant || germ cell resistant ionizing radiation |
| Lipocalins | 0.4443 | INHERITED FROM: paraquat hypersensitive |
| cAMP-binding domain-like | 0.4443 | INHERITED FROM: thermosensory behavior variant || organism temperature response variant || thermotaxis variant |
| Insulin-like | 0.5789 | INHERITED FROM: temperature induced dauer formation variant |
| WD40 repeat-like | 0.6959 | INHERITED FROM: pathogen induced antimicrobial gene expression variant |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.7268 | INHERITED FROM: cell gamma ray response variant || organism gamma ray response variant || gamma ray induced apoptosis increased |
| HLH, helix-loop-helix DNA-binding domain | 0.8297 | INHERITED FROM: fungal resistance increased || pathogen resistance increased || hypoxia response variant |
| Metallo-dependent phosphatases | 0.8532 | INHERITED FROM: radiation induced germ cell apoptosis variant || germ cell resistant ionizing radiation |
| Cysteine proteinases | 0.9454 | INHERITED FROM: paraquat hypersensitive |
| Protein kinase-like (PK-like) | 0.96 | INHERITED FROM: organism osmotic stress hypersensitive || organism oxidative stress response variant || anoxia resistant || hypoxia response variant |
| Periplasmic binding protein-like I | 0.9756 | INHERITED FROM: thermosensory behavior variant || organism temperature response variant || thermotaxis variant |
| P-loop containing nucleoside triphosphate hydrolases | 0.9817 | INHERITED FROM: pathogen release variant || organism UV response variant || organism hypersensitive ionizing radiation |
| MFS general substrate transporter | 1 | INHERITED FROM: organism high sodium chloride hypersensitive |
| Nucleotide cyclase | 1 | INHERITED FROM: thermotaxis variant |
| Tubulin C-terminal domain-like | 1 | INHERITED FROM: no induction of antimicrobial peptide expression after infection |
| Nicotinic receptor ligand binding domain-like | 1 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
| EF-hand | 1 | INHERITED FROM: cellular osmotic stress response variant |
| Neurotransmitter-gated ion-channel transmembrane pore | 1 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| HRDC-like | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00000009003 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.0000007594 | Direct |
| GST C-terminal domain-like | 0.00001682 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.00002609 | Direct |
| PIN domain-like | 0.00002659 | Direct |
| Thioredoxin-like | 0.00003294 | Direct |
| F1F0 ATP synthase subunit C | 0.0001688 | Direct |
| ARID-like | 0.0001688 | Direct |
| Aquaporin-like | 0.0002817 | Direct |
| Class II aaRS ABD-related | 0.0005064 | Direct |
| Cysteine-rich domain | 0.000759 | Direct |
| Di-copper centre-containing domain | 0.0008351 | Direct |
| PLC-like phosphodiesterases | 0.002439 | Inherited |
| NAD kinase/diacylglycerol kinase-like | 0.002699 | Inherited |
| Class II aaRS and biotin synthetases | 0.003205 | Inherited |
| Saposin | 0.003843 | Inherited |
| PH domain-like | 0.004509 | Inherited |
| Nucleotidylyl transferase | 0.007673 | Inherited |
| HSP20-like chaperones | 0.008252 | Inherited |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.01096 | Inherited |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.02105 | Inherited |
| ACP-like | 0.02149 | Inherited |
| DBL homology domain (DH-domain) | 0.02629 | Inherited |
| GroEL equatorial domain-like | 0.03356 | Inherited |
| GroEL apical domain-like | 0.03356 | Inherited |
| GroEL-intermediate domain like | 0.03356 | Inherited |
| Multidrug resistance efflux transporter EmrE | 0.03881 | Inherited |
| Bromodomain | 0.05322 | Inherited |
| Hect, E3 ligase catalytic domain | 0.08419 | Inherited |
| RING/U-box | 0.09519 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.09966 | Inherited |
| Chromo domain-like | 0.1022 | Inherited |
| Ankyrin repeat | 0.1056 | Inherited |
| Periplasmic binding protein-like II | 0.123 | Inherited |
| Heme-dependent peroxidases | 0.1325 | Inherited |
| HD-domain/PDEase-like | 0.1325 | Inherited |
| Histone-fold | 0.1654 | Inherited |
| (Trans)glycosidases | 0.1958 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.207 | Inherited |
| Arginase/deacetylase | 0.207 | Inherited |
| DNA/RNA polymerases | 0.2485 | Inherited |
| DEATH domain | 0.2485 | Inherited |
| RNA-binding domain, RBD | 0.2608 | Inherited |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.2647 | Inherited |
| Nucleic acid-binding proteins | 0.2904 | Inherited |
| FAD/NAD(P)-binding domain | 0.2986 | Inherited |
| Leucine zipper domain | 0.3383 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.345 | Inherited |
| Sm-like ribonucleoproteins | 0.345 | Inherited |
| FYVE/PHD zinc finger | 0.358 | Inherited |
| PLP-dependent transferases | 0.404 | Inherited |
| Lipocalins | 0.4443 | Inherited |
| cAMP-binding domain-like | 0.4443 | Inherited |
| Insulin-like | 0.5789 | Inherited |
| WD40 repeat-like | 0.6959 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.7268 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.8297 | Inherited |
| Metallo-dependent phosphatases | 0.8532 | Inherited |
| Cysteine proteinases | 0.9454 | Inherited |
| Protein kinase-like (PK-like) | 0.96 | Inherited |
| Periplasmic binding protein-like I | 0.9756 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 0.9817 | Inherited |
| MFS general substrate transporter | 1 | Inherited |
| Nucleotide cyclase | 1 | Inherited |
| Tubulin C-terminal domain-like | 1 | Inherited |
| Nicotinic receptor ligand binding domain-like | 1 | Inherited |
| EF-hand | 1 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (SPWP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | DIRECT |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0 | DIRECT |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | DIRECT |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
48431,56968
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00000009003 | DIRECT |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.00009505 | DIRECT |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.0001005 | DIRECT |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0001512 | DIRECT |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.0001688 | DIRECT |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.001072 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.01096 | INHERITED FROM: paraquat response variant || organism oxidative stress response variant |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.01317 | INHERITED FROM: organism pathogen response variant || pathogen resistance increased || bacterially unswollen |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0.02149 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.03356 | INHERITED FROM: pathogen induced antimicrobial gene expression variant || no induction of antimicrobial peptide expression after infection || cell stress response variant || organism temperature response variant || unfolded protein response variant || innate immune response variant |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.03356 | INHERITED FROM: pathogen induced antimicrobial gene expression variant || no induction of antimicrobial peptide expression after infection || cell stress response variant || organism temperature response variant || unfolded protein response variant || innate immune response variant |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.1235 | INHERITED FROM: starvation induced apoptosis variant || organism starvation response variant |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.1325 | INHERITED FROM: hypoxia resistant || hypoxia response variant |
53300,56436
53300 - vWA-like
56436 - C-type lectin-like | 0.2108 | INHERITED FROM: pathogen induced death increased || pathogen susceptibility increased |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 1 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
48452,48452
48452 - TPR-like
48452 - TPR-like | 1 | INHERITED FROM: organism temperature response variant |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | Direct |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | Direct |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0 | Direct |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | Direct |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
48431,56968
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00000009003 | Direct |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.00009505 | Direct |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.0001005 | Direct |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0001512 | Direct |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.0001688 | Direct |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.001072 | Inherited |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.01096 | Inherited |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.01317 | Inherited |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0.02149 | Inherited |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.03356 | Inherited |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.03356 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.1235 | Inherited |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.1325 | Inherited |
53300,56436
53300 - vWA-like
56436 - C-type lectin-like | 0.2108 | Inherited |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 1 | Inherited |
48452,48452
48452 - TPR-like
48452 - TPR-like | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (SPWP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
56968,48431,56968
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00000009003 | DIRECT |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.001072 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.001072 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.03356 | INHERITED FROM: pathogen induced antimicrobial gene expression variant || no induction of antimicrobial peptide expression after infection || cell stress response variant || organism temperature response variant || unfolded protein response variant || innate immune response variant |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
56968,48431,56968
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00000009003 | Direct |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.001072 | Inherited |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.001072 | Inherited |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.03356 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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