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Worm Phenotype (WP): organism behavior variant
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this WP term (SDWP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Cytochrome P450 | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| Multidrug efflux transporter AcrB transmembrane domain | 0.00000000000009802 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0.0000000000005715 | DIRECT |
| HSP20-like chaperones | 0.000000000009769 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0.00000000002457 | DIRECT |
| Histone-fold | 0.0000000001437 | DIRECT |
| Periplasmic binding protein-like I | 0.000000001529 | DIRECT |
| Nucleotide cyclase | 0.000000004496 | DIRECT |
| Insulin-like | 0.000000008417 | DIRECT |
| ARM repeat | 0.0000002876 | DIRECT |
| TPR-like | 0.0000008284 | DIRECT |
| Band 7/SPFH domain | 0.000003392 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.00000474 | DIRECT |
| Bromodomain | 0.000005343 | DIRECT |
| Actin-like ATPase domain | 0.00001397 | DIRECT |
| GroEL-intermediate domain like | 0.00001857 | DIRECT |
| GroEL equatorial domain-like | 0.00001857 | DIRECT |
| Sm-like ribonucleoproteins | 0.00002241 | DIRECT |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.00002327 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0.00002617 | DIRECT |
| Tubulin C-terminal domain-like | 0.00006525 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0.0001074 | DIRECT |
| GroEL apical domain-like | 0.0001337 | DIRECT |
| PH domain-like | 0.0001652 | DIRECT |
| SNF-like | 0.0001858 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0.0001858 | DIRECT |
| SMAD/FHA domain | 0.0002805 | DIRECT |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.0003504 | DIRECT |
| Growth factor receptor domain | 0.0004397 | DIRECT |
| Tropomyosin | 0.0005296 | DIRECT |
| Class II aaRS and biotin synthetases | 0.0008368 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.0009034 | DIRECT |
| Cysteine-rich domain | 0.00133 | INHERITED FROM: eating variant || odorant positive chemotaxis variant || positive chemotaxis variant || thermosensory behavior variant || odorant chemosensory response variant || thermotaxis variant |
| Prefoldin | 0.001418 | INHERITED FROM: locomotion variant |
| Hedgehog/intein (Hint) domain | 0.001582 | INHERITED FROM: movement variant || locomotion variant |
| NAD(P)-linked oxidoreductase | 0.003039 | INHERITED FROM: defecation variant || defecation cycle variant |
| Nucleic acid-binding proteins | 0.00316 | INHERITED FROM: avoids bacterial lawn |
| F1F0 ATP synthase subunit C | 0.003208 | INHERITED FROM: avoids bacterial lawn |
| ARID-like | 0.003208 | INHERITED FROM: organism UV hypersensitive || light response variant || organism UV response variant |
| S15/NS1 RNA-binding domain | 0.003208 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| Frizzled cysteine-rich domain | 0.003208 | INHERITED FROM: body muscle dystrophy || organism region behavior variant || body behavior variant || organism segment behavior variant |
| Spectrin repeat | 0.004183 | INHERITED FROM: movement variant || locomotion variant |
| Zn-binding ribosomal proteins | 0.004433 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| cAMP-binding domain-like | 0.007379 | INHERITED FROM: head bend angle variant || male mating defective || coiling variant || odorant positive chemotaxis variant || benzaldehyde chemotaxis defective || positive chemotaxis variant || positive chemotaxis defective || turning frequency variant || thermosensory behavior variant || odorant chemosensory response variant || egg laying defective || frequency of body bend variant || body posture wavelength variant || odorant negative chemotaxis defective || body bend variant || backward point velocity variant || male mating variant || chemosensory behavior variant || roller || nose movement variant || bloated || path curvature variant || body posture amplitude variant || sodium chloride chemotaxis variant || turning variant || benzaldehyde chemotaxis variant || amplitude of sinusoidal movement variant || head movement variant || butanone chemotaxis variant || sodium chloride chemotaxis defective || forward point velocity variant || chemotaxis variant || thermotaxis variant || odorant positive chemotaxis defective || coiling frequency variant || directionality variant |
| EGF/Laminin | 0.009042 | INHERITED FROM: movement variant || odorant negative chemotaxis defective || octanol chemotaxis variant || octanol chemotaxis defective || locomotion variant |
| Translation proteins SH3-like domain | 0.00909 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| E2F-DP heterodimerization region | 0.01112 | INHERITED FROM: backward locomotion variant || locomotor coordination variant || reversal variant || directionality variant |
| Cu,Zn superoxide dismutase-like | 0.01112 | INHERITED FROM: defecation variant || defecation cycle variant || defecation cycle variable length |
| Integrin domains | 0.01112 | INHERITED FROM: egg laying variant |
| PYP-like sensor domain (PAS domain) | 0.01265 | INHERITED FROM: egg laying defective || egg laying variant |
| WD40 repeat-like | 0.01535 | INHERITED FROM: osmotic avoidance variant |
| PLC-like phosphodiesterases | 0.01717 | INHERITED FROM: male mating defective || spicule insertion defective || male mating variant || sexually dimorphic behavior variant || defecation variant || ovulation variant || defecation contraction variant || copulation variant || posterior body wall contraction defecation cycle variant |
| Fibronectin type III | 0.01765 | INHERITED FROM: forward locomotion decreased || body posture variant || reversal variant || path curvature increased || locomotion reduced |
| Intermediate filament protein, coiled coil region | 0.02186 | INHERITED FROM: paralyzed |
| Lamin A/C globular tail domain | 0.02186 | INHERITED FROM: paralyzed |
| Arginase/deacetylase | 0.02745 | INHERITED FROM: organism UV hypersensitive || light response variant || organism UV response variant |
| SH3-domain | 0.02821 | INHERITED FROM: ovulation variant |
| FYVE/PHD zinc finger | 0.02904 | INHERITED FROM: organism UV hypersensitive || light response variant || organism UV response variant |
| beta-beta-alpha zinc fingers | 0.04378 | INHERITED FROM: egg laying imipramine resistant |
| Periplasmic binding protein-like II | 0.04654 | INHERITED FROM: eating variant || positive chemotaxis defective || thermosensory behavior variant || aqueous positive chemotaxis defective || chemosensory behavior variant || aqueous positive chemotaxis variant || sodium chloride chemotaxis variant || chemosensory response variant || sodium chloride chemotaxis defective || chemotaxis variant || thermotaxis variant || pharyngeal pumping rate variant || pharyngeal pumping reduced |
| FKBP-like | 0.05019 | INHERITED FROM: postembryonic behavior variant || dauer behavior variant || developmental behavior variant |
| Ligand-binding domain in the NO signalling and Golgi transport | 0.05019 | INHERITED FROM: eating variant || induced pharyngeal pumping variant || pharyngeal pumping rate variant |
| HD-domain/PDEase-like | 0.05019 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
| DNA/RNA polymerases | 0.06148 | INHERITED FROM: organism UV hypersensitive || light response variant || organism UV response variant |
| Class II aaRS ABD-related | 0.06543 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.0815 | INHERITED FROM: avoids bacterial lawn |
| Lipovitellin-phosvitin complex, superhelical domain | 0.0845 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.0845 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| PDZ domain-like | 0.08539 | INHERITED FROM: body muscle dystrophy || organism region behavior variant || body behavior variant || ovulation variant || organism segment behavior variant |
| NTF2-like | 0.09936 | INHERITED FROM: male mating defective || male mating variant |
| Nucleotidylyl transferase | 0.1004 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.1084 | INHERITED FROM: avoids bacterial lawn |
| Myosin rod fragments | 0.1084 | INHERITED FROM: sluggish |
| L30e-like | 0.1084 | INHERITED FROM: avoids bacterial lawn |
| Regulator of G-protein signaling, RGS | 0.1302 | INHERITED FROM: negative chemotaxis variant || chemotaxis variant || mechanosensation variant |
| Glutathione synthetase ATP-binding domain-like | 0.1648 | INHERITED FROM: negative chemotaxis variant || osmotic avoidance variant || male mating variant || chemosensory behavior variant || sexually dimorphic behavior variant || male mating efficiency reduced || copulation variant || chemotaxis variant |
| EF-hand | 0.1894 | INHERITED FROM: ovulation variant || defecation contraction variant |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0.2035 | INHERITED FROM: defecation variant || defecation cycle variant |
| Acyl-CoA dehydrogenase NM domain-like | 0.2035 | INHERITED FROM: defecation variant || defecation cycle variant |
| Chromo domain-like | 0.2104 | INHERITED FROM: organism UV hypersensitive || light response variant || organism UV response variant |
| PLP-dependent transferases | 0.2924 | INHERITED FROM: path curvature decreased || defecation contraction variant || forward locomotion increased || expulsion variant || body posture amplitude increased |
| Ubiquitin-like | 0.3739 | INHERITED FROM: body muscle dystrophy || organism region behavior variant || body behavior variant || organism segment behavior variant |
| NAD kinase/diacylglycerol kinase-like | 0.3772 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
| LDL receptor-like module | 0.4057 | INHERITED FROM: paralyzed |
| Protein kinase-like (PK-like) | 0.4599 | INHERITED FROM: velocity of movement increased || body muscle dystrophy || positive chemotaxis variant || alkaline pH chemotaxis variant || postembryonic behavior variant || aqueous chemosensory response variant || organism region behavior variant || dauer nictation behavior variant || chemosensory behavior variant || egg laying response to food variant || dauer behavior variant || octanol chemotaxis defective || late stage egg laid || organism segment behavior variant || developmental behavior variant || mechanosensation variant |
| Ankyrin repeat | 0.4816 | INHERITED FROM: head bend angle variant || localized movement variant || turning frequency variant || forward locomotion variant || body posture wavelength decreased || odorant negative chemotaxis defective || body bend variant || backward locomotion variant || sinusoidal movement variant || body posture variant || octanol chemotaxis variant || nose movement variant || octanol chemotaxis defective || chemosensory response variant || turning variant || head movement variant || tail movement variant || chemotaxis variant || reversal variant || tail bend angle variant |
| FAD/NAD(P)-binding domain | 0.6728 | INHERITED FROM: fewer eggs laid |
| BPTI-like | 0.7352 | INHERITED FROM: male mating defective |
| Homeodomain-like | 0.7693 | INHERITED FROM: forward locomotion decreased || coiling variant || backward locomotion variant || foraging reduced || egg laying imipramine resistant || roaming reduced || quiescence variant || coiling frequency variant |
| Saposin | 0.8138 | INHERITED FROM: fewer eggs laid |
| RNA-binding domain, RBD | 0.8452 | INHERITED FROM: locomotion variant || unfertilized oocytes laid |
| "Winged helix" DNA-binding domain | 0.8551 | INHERITED FROM: body muscle dystrophy || body behavior variant |
| Voltage-gated potassium channels | 0.9022 | INHERITED FROM: head bend angle variant || eating variant || localized movement variant || positive chemotaxis defective || plate tap habituation variant || turning frequency variant || forward locomotion variant || expulsion defective || hyperactive egg laying || spicule insertion defective || egg laying defective || body bend variant || backward point velocity variant || backward locomotion variant || body posture variant || roller || bag of worms || bloated || activity level variant || flaccid || head movement variant || expulsion variant || locomotor coordination variant || forward point velocity variant || habituation variant || coiling frequency variant || tail bend angle variant || mechanosensation variant |
| C-type lectin-like | 1 | INHERITED FROM: male mating defective || male mating variant || sexually dimorphic behavior variant || copulation variant |
| Glucocorticoid receptor-like (DNA-binding domain) | 1 | INHERITED FROM: solitary feeding increased |
| Immunoglobulin | 1 | INHERITED FROM: movement variant || body posture variant || locomotion reduced |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: serotonin induced pumping variant || induced pharyngeal pumping variant |
| Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: solitary feeding increased |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Cytochrome c | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Cytochrome P450 | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| Multidrug efflux transporter AcrB transmembrane domain | 0.00000000000009802 | Direct |
| Transducin (alpha subunit), insertion domain | 0.0000000000005715 | Direct |
| HSP20-like chaperones | 0.000000000009769 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0.00000000002457 | Direct |
| Histone-fold | 0.0000000001437 | Direct |
| Periplasmic binding protein-like I | 0.000000001529 | Direct |
| Nucleotide cyclase | 0.000000004496 | Direct |
| Insulin-like | 0.000000008417 | Direct |
| ARM repeat | 0.0000002876 | Direct |
| TPR-like | 0.0000008284 | Direct |
| Band 7/SPFH domain | 0.000003392 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.00000474 | Direct |
| Bromodomain | 0.000005343 | Direct |
| Actin-like ATPase domain | 0.00001397 | Direct |
| GroEL-intermediate domain like | 0.00001857 | Direct |
| GroEL equatorial domain-like | 0.00001857 | Direct |
| Sm-like ribonucleoproteins | 0.00002241 | Direct |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.00002327 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0.00002617 | Direct |
| Tubulin C-terminal domain-like | 0.00006525 | Direct |
| Nicotinic receptor ligand binding domain-like | 0.0001074 | Direct |
| GroEL apical domain-like | 0.0001337 | Direct |
| PH domain-like | 0.0001652 | Direct |
| SNF-like | 0.0001858 | Direct |
| Tubulin nucleotide-binding domain-like | 0.0001858 | Direct |
| SMAD/FHA domain | 0.0002805 | Direct |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.0003504 | Direct |
| Growth factor receptor domain | 0.0004397 | Direct |
| Tropomyosin | 0.0005296 | Direct |
| Class II aaRS and biotin synthetases | 0.0008368 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.0009034 | Direct |
| Cysteine-rich domain | 0.00133 | Inherited |
| Prefoldin | 0.001418 | Inherited |
| Hedgehog/intein (Hint) domain | 0.001582 | Inherited |
| NAD(P)-linked oxidoreductase | 0.003039 | Inherited |
| Nucleic acid-binding proteins | 0.00316 | Inherited |
| F1F0 ATP synthase subunit C | 0.003208 | Inherited |
| ARID-like | 0.003208 | Inherited |
| S15/NS1 RNA-binding domain | 0.003208 | Inherited |
| Frizzled cysteine-rich domain | 0.003208 | Inherited |
| Spectrin repeat | 0.004183 | Inherited |
| Zn-binding ribosomal proteins | 0.004433 | Inherited |
| cAMP-binding domain-like | 0.007379 | Inherited |
| EGF/Laminin | 0.009042 | Inherited |
| Translation proteins SH3-like domain | 0.00909 | Inherited |
| E2F-DP heterodimerization region | 0.01112 | Inherited |
| Cu,Zn superoxide dismutase-like | 0.01112 | Inherited |
| Integrin domains | 0.01112 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.01265 | Inherited |
| WD40 repeat-like | 0.01535 | Inherited |
| PLC-like phosphodiesterases | 0.01717 | Inherited |
| Fibronectin type III | 0.01765 | Inherited |
| Intermediate filament protein, coiled coil region | 0.02186 | Inherited |
| Lamin A/C globular tail domain | 0.02186 | Inherited |
| Arginase/deacetylase | 0.02745 | Inherited |
| SH3-domain | 0.02821 | Inherited |
| FYVE/PHD zinc finger | 0.02904 | Inherited |
| beta-beta-alpha zinc fingers | 0.04378 | Inherited |
| Periplasmic binding protein-like II | 0.04654 | Inherited |
| FKBP-like | 0.05019 | Inherited |
| Ligand-binding domain in the NO signalling and Golgi transport | 0.05019 | Inherited |
| HD-domain/PDEase-like | 0.05019 | Inherited |
| DNA/RNA polymerases | 0.06148 | Inherited |
| Class II aaRS ABD-related | 0.06543 | Inherited |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.0815 | Inherited |
| Lipovitellin-phosvitin complex, superhelical domain | 0.0845 | Inherited |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.0845 | Inherited |
| PDZ domain-like | 0.08539 | Inherited |
| NTF2-like | 0.09936 | Inherited |
| Nucleotidylyl transferase | 0.1004 | Inherited |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.1084 | Inherited |
| Myosin rod fragments | 0.1084 | Inherited |
| L30e-like | 0.1084 | Inherited |
| Regulator of G-protein signaling, RGS | 0.1302 | Inherited |
| Glutathione synthetase ATP-binding domain-like | 0.1648 | Inherited |
| EF-hand | 0.1894 | Inherited |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0.2035 | Inherited |
| Acyl-CoA dehydrogenase NM domain-like | 0.2035 | Inherited |
| Chromo domain-like | 0.2104 | Inherited |
| PLP-dependent transferases | 0.2924 | Inherited |
| Ubiquitin-like | 0.3739 | Inherited |
| NAD kinase/diacylglycerol kinase-like | 0.3772 | Inherited |
| LDL receptor-like module | 0.4057 | Inherited |
| Protein kinase-like (PK-like) | 0.4599 | Inherited |
| Ankyrin repeat | 0.4816 | Inherited |
| FAD/NAD(P)-binding domain | 0.6728 | Inherited |
| BPTI-like | 0.7352 | Inherited |
| Homeodomain-like | 0.7693 | Inherited |
| Saposin | 0.8138 | Inherited |
| RNA-binding domain, RBD | 0.8452 | Inherited |
| "Winged helix" DNA-binding domain | 0.8551 | Inherited |
| Voltage-gated potassium channels | 0.9022 | Inherited |
| C-type lectin-like | 1 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 1 | Inherited |
| Immunoglobulin | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
| Nuclear receptor ligand-binding domain | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this WP term (SDWP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| a tRNA synthase domain | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| Laminin-type module | 0 | DIRECT |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
| RhoGDI-like | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| HSP20 | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| RNA-polymerase beta | 0 | DIRECT |
| Phoshatidylinositol transfer protein, PITP | 0 | DIRECT |
| Mammalian PLC | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Trunk domain of Sec23/24 | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Troponin I | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| Cytochrome P450 | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Multidrug efflux transporter AcrB transmembrane domain | 0.0000000000146 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0.00000000002413 | DIRECT |
| Actin/HSP70 | 0.000000003194 | DIRECT |
| Homeodomain | 0.00000002368 | DIRECT |
| Nucleosome core histones | 0.00000003724 | DIRECT |
| Insulin-like | 0.0000002218 | DIRECT |
| Proteasome subunits | 0.0000002406 | DIRECT |
| Adenylyl and guanylyl cyclase catalytic domain | 0.0000002827 | DIRECT |
| L-arabinose binding protein-like | 0.0000004797 | DIRECT |
| Pleckstrin-homology domain (PH domain) | 0.000007837 | DIRECT |
| Bromodomain | 0.00003691 | DIRECT |
| Band 7/SPFH domain | 0.00007062 | DIRECT |
| PLC-like (P variant) | 0.0001698 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.0002073 | DIRECT |
| SMAD domain | 0.0002172 | DIRECT |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.0002172 | DIRECT |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.0002648 | DIRECT |
| SNF-like | 0.0003402 | DIRECT |
| Tubulin, C-terminal domain | 0.0003922 | DIRECT |
| PHD domain | 0.0004333 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0.0004535 | DIRECT |
| G proteins | 0.0005053 | DIRECT |
| PDZ domain | 0.0006318 | DIRECT |
| acyl-CoA oxidase C-terminal domains | 0.0006635 | DIRECT |
| acyl-CoA oxidase N-terminal domains | 0.0006635 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0.0008866 | DIRECT |
| Tubulin, GTPase domain | 0.0009324 | DIRECT |
| Synaptotagmin-like (S variant) | 0.0009324 | DIRECT |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.0009685 | DIRECT |
| Tetratricopeptide repeat (TPR) | 0.001235 | INHERITED FROM: movement variant |
| Group II chaperonin (CCT, TRIC), apical domain | 0.001314 | INHERITED FROM: avoids bacterial lawn |
| Tandem AAA-ATPase domain | 0.001415 | INHERITED FROM: light response variant || organism UV response variant |
| Canonical RBD | 0.001762 | INHERITED FROM: locomotion variant || unfertilized oocytes laid |
| Tropomyosin | 0.001781 | INHERITED FROM: sluggish || locomotion variant || locomotion reduced |
| PDEase | 0.002015 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
| RecA protein-like (ATPase-domain) | 0.002015 | INHERITED FROM: avoids bacterial lawn |
| Growth factor receptor domain | 0.002172 | INHERITED FROM: quiescence variant |
| Spectrin repeat | 0.004481 | INHERITED FROM: movement variant || locomotion variant |
| Hedgehog C-terminal (Hog) autoprocessing domain | 0.004481 | INHERITED FROM: movement variant || locomotion variant |
| Ubiquitin activating enzymes (UBA) | 0.006058 | INHERITED FROM: movement variant || locomotion variant |
| ARID domain | 0.006058 | INHERITED FROM: organism UV hypersensitive || light response variant || organism UV response variant |
| Smc hinge domain | 0.006058 | INHERITED FROM: movement variant || locomotion variant |
| Frizzled cysteine-rich domain | 0.006058 | INHERITED FROM: body muscle dystrophy || organism region behavior variant || body behavior variant || organism segment behavior variant |
| F1F0 ATP synthase subunit C | 0.006058 | INHERITED FROM: avoids bacterial lawn |
| I set domains | 0.008422 | INHERITED FROM: forward locomotion decreased || movement variant || body posture variant || pausing increased || path curvature increased || locomotion reduced |
| Clathrin coat assembly domain | 0.009493 | INHERITED FROM: movement variant || locomotion variant |
| Aldo-keto reductases (NADP) | 0.0102 | INHERITED FROM: defecation variant || defecation cycle variant |
| cAMP-binding domain | 0.01091 | INHERITED FROM: head bend angle variant || male mating defective || coiling variant || odorant positive chemotaxis variant || benzaldehyde chemotaxis defective || positive chemotaxis variant || positive chemotaxis defective || turning frequency variant || thermosensory behavior variant || odorant chemosensory response variant || egg laying defective || frequency of body bend variant || body posture wavelength variant || odorant negative chemotaxis defective || backward point velocity variant || male mating variant || chemosensory behavior variant || roller || nose movement variant || bloated || path curvature variant || body posture amplitude variant || sodium chloride chemotaxis variant || turning variant || benzaldehyde chemotaxis variant || amplitude of sinusoidal movement variant || head movement variant || butanone chemotaxis variant || sodium chloride chemotaxis defective || forward point velocity variant || chemotaxis variant || thermotaxis variant || odorant positive chemotaxis defective || coiling frequency variant || directionality variant |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.01274 | INHERITED FROM: eating variant || odorant positive chemotaxis variant || thermosensory behavior variant || nose touch variant || thermotaxis variant |
| H-NOX domain | 0.01807 | INHERITED FROM: eating variant || induced pharyngeal pumping variant || pharyngeal pumping rate variant || feeding behavior variant |
| Anticodon-binding domain | 0.01807 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| Cu,Zn superoxide dismutase-like | 0.01807 | INHERITED FROM: defecation variant || defecation cycle variant || defecation cycle variable length |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0.01807 | INHERITED FROM: defecation variant |
| Cell cycle transcription factor e2f-dp | 0.01807 | INHERITED FROM: backward locomotion variant || locomotor coordination variant || reversal variant || directionality variant |
| LIM domain | 0.0253 | INHERITED FROM: eating variant |
| Histone deacetylase, HDAC | 0.02615 | INHERITED FROM: organism UV hypersensitive || light response variant || organism UV response variant |
| Extended AAA-ATPase domain | 0.0273 | INHERITED FROM: feeding behavior variant |
| WD40-repeat | 0.02841 | INHERITED FROM: osmotic avoidance variant |
| Rhodopsin-like | 0.03334 | INHERITED FROM: fewer egg laying events during active || active phase variant || head bend angle variant || movement variant || eating variant || localized movement variant || foraging behavior variant || velocity of movement variant || satiety behavior variant || turning frequency variant || amplitude of sinusoidal movement decreased || pausing variant || forward locomotion variant || egg laying phases variant || body bend variant || backward locomotion variant || sinusoidal movement variant || egg laying variant || body posture variant || serotonin induced pumping variant || nose movement variant || induced pharyngeal pumping variant || head movement variant || aqueous adaptation defective || locomotor coordination variant || egg laying response to drug variant || coiling frequency variant || directionality variant || tail bend angle variant |
| Phosphate binding protein-like | 0.04242 | INHERITED FROM: eating variant || positive chemotaxis defective || thermosensory behavior variant || aqueous positive chemotaxis defective || chemosensory behavior variant || aqueous positive chemotaxis variant || sodium chloride chemotaxis variant || chemosensory response variant || sodium chloride chemotaxis defective || chemotaxis variant || thermotaxis variant || pharyngeal pumping rate variant || pharyngeal pumping reduced |
| Intermediate filament protein, coiled coil region | 0.04844 | INHERITED FROM: paralyzed |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.05006 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| Pyridoxal-dependent decarboxylase | 0.05447 | INHERITED FROM: forward point velocity increased || localized movement variant || foraging behavior variant || turning frequency variant || forward locomotion variant || roaming increased || body posture wavelength variant || body bend variant || backward point velocity variant || backward locomotion variant || sinusoidal movement variant || egg laying variant || body posture variant || path curvature decreased || backward point velocity increased || body posture amplitude variant || activity level variant || amplitude of sinusoidal movement variant || head movement variant || forward locomotion increased || locomotor coordination variant || forward point velocity variant || reversal variant || egg laying response to drug variant || body posture amplitude increased || directionality variant || tail bend angle variant |
| Lamin A/C globular tail domain | 0.05447 | INHERITED FROM: paralyzed |
| Transforming growth factor (TGF)-beta | 0.06178 | INHERITED FROM: egg laying defective || egg laying variant |
| L30e/L7ae ribosomal proteins | 0.06178 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| DEP domain | 0.06178 | INHERITED FROM: body muscle dystrophy || organism region behavior variant || body behavior variant || organism segment behavior variant |
| Fibronectin type III | 0.0876 | INHERITED FROM: forward locomotion decreased || body posture variant || path curvature increased || locomotion reduced |
| FKBP immunophilin/proline isomerase | 0.09534 | INHERITED FROM: postembryonic behavior variant || dauer behavior variant || developmental behavior variant |
| Lipovitellin-phosvitin complex, superhelical domain | 0.1298 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.1298 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| SH3-domain | 0.1545 | INHERITED FROM: ovulation variant |
| Motor proteins | 0.1666 | INHERITED FROM: sexually dimorphic mechanosensation variant || post hermaphrodite contact variant || male response to hermaphrodite variant || vulva location variant |
| Myosin rod fragments | 0.1787 | INHERITED FROM: sluggish |
| Regulator of G-protein signaling, RGS | 0.2143 | INHERITED FROM: negative chemotaxis variant || chemotaxis variant || mechanosensation variant |
| EGF-type module | 0.2354 | INHERITED FROM: activity level variant |
| Chromo domain | 0.2822 | INHERITED FROM: organism UV hypersensitive || light response variant || organism UV response variant |
| LDL receptor-like module | 0.6199 | INHERITED FROM: paralyzed |
| Protein kinases, catalytic subunit | 0.67 | INHERITED FROM: velocity of movement increased || body muscle dystrophy || positive chemotaxis variant || alkaline pH chemotaxis variant || postembryonic behavior variant || organism region behavior variant || dauer nictation behavior variant || chemosensory behavior variant || egg laying response to food variant || dauer behavior variant || octanol chemotaxis defective || organism segment behavior variant || mechanosensation variant |
| Ankyrin repeat | 0.8439 | INHERITED FROM: head bend angle variant || localized movement variant || turning frequency variant || forward locomotion variant || body posture wavelength decreased || odorant negative chemotaxis defective || body bend variant || backward locomotion variant || sinusoidal movement variant || octanol chemotaxis variant || nose movement variant || octanol chemotaxis defective || turning variant || head movement variant || tail movement variant || reversal variant || tail bend angle variant |
| Integrin A (or I) domain | 0.8895 | INHERITED FROM: paralyzed |
| Voltage-gated potassium channels | 0.9774 | INHERITED FROM: head bend angle variant || eating variant || localized movement variant || plate tap habituation variant || turning frequency variant || forward locomotion variant || expulsion defective || egg laying defective || body bend variant || backward point velocity variant || body posture variant || roller || nose movement variant || flaccid || head movement variant || expulsion variant || locomotor coordination variant || forward point velocity variant || habituation variant || coiling frequency variant |
| Nuclear receptor | 1 | INHERITED FROM: solitary feeding increased |
| Acetylcholinesterase-like | 1 | INHERITED FROM: swimming variant |
| Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: solitary feeding increased |
| C-type lectin domain | 1 | INHERITED FROM: male mating defective || male mating variant || sexually dimorphic behavior variant || copulation variant |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| a tRNA synthase domain | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| Laminin-type module | 0 | Direct |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
| RhoGDI-like | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| HSP20 | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| RNA-polymerase beta | 0 | Direct |
| Phoshatidylinositol transfer protein, PITP | 0 | Direct |
| Mammalian PLC | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| Trunk domain of Sec23/24 | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Troponin I | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Integrin domains | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| Cytochrome P450 | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Multidrug efflux transporter AcrB transmembrane domain | 0.0000000000146 | Direct |
| Transducin (alpha subunit), insertion domain | 0.00000000002413 | Direct |
| Actin/HSP70 | 0.000000003194 | Direct |
| Homeodomain | 0.00000002368 | Direct |
| Nucleosome core histones | 0.00000003724 | Direct |
| Insulin-like | 0.0000002218 | Direct |
| Proteasome subunits | 0.0000002406 | Direct |
| Adenylyl and guanylyl cyclase catalytic domain | 0.0000002827 | Direct |
| L-arabinose binding protein-like | 0.0000004797 | Direct |
| Pleckstrin-homology domain (PH domain) | 0.000007837 | Direct |
| Bromodomain | 0.00003691 | Direct |
| Band 7/SPFH domain | 0.00007062 | Direct |
| PLC-like (P variant) | 0.0001698 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.0002073 | Direct |
| SMAD domain | 0.0002172 | Direct |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.0002172 | Direct |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.0002648 | Direct |
| SNF-like | 0.0003402 | Direct |
| Tubulin, C-terminal domain | 0.0003922 | Direct |
| PHD domain | 0.0004333 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0.0004535 | Direct |
| G proteins | 0.0005053 | Direct |
| PDZ domain | 0.0006318 | Direct |
| acyl-CoA oxidase C-terminal domains | 0.0006635 | Direct |
| acyl-CoA oxidase N-terminal domains | 0.0006635 | Direct |
| Nicotinic receptor ligand binding domain-like | 0.0008866 | Direct |
| Tubulin, GTPase domain | 0.0009324 | Direct |
| Synaptotagmin-like (S variant) | 0.0009324 | Direct |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.0009685 | Direct |
| Tetratricopeptide repeat (TPR) | 0.001235 | Inherited |
| Group II chaperonin (CCT, TRIC), apical domain | 0.001314 | Inherited |
| Tandem AAA-ATPase domain | 0.001415 | Inherited |
| Canonical RBD | 0.001762 | Inherited |
| Tropomyosin | 0.001781 | Inherited |
| PDEase | 0.002015 | Inherited |
| RecA protein-like (ATPase-domain) | 0.002015 | Inherited |
| Growth factor receptor domain | 0.002172 | Inherited |
| Spectrin repeat | 0.004481 | Inherited |
| Hedgehog C-terminal (Hog) autoprocessing domain | 0.004481 | Inherited |
| Ubiquitin activating enzymes (UBA) | 0.006058 | Inherited |
| ARID domain | 0.006058 | Inherited |
| Smc hinge domain | 0.006058 | Inherited |
| Frizzled cysteine-rich domain | 0.006058 | Inherited |
| F1F0 ATP synthase subunit C | 0.006058 | Inherited |
| I set domains | 0.008422 | Inherited |
| Clathrin coat assembly domain | 0.009493 | Inherited |
| Aldo-keto reductases (NADP) | 0.0102 | Inherited |
| cAMP-binding domain | 0.01091 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.01274 | Inherited |
| H-NOX domain | 0.01807 | Inherited |
| Anticodon-binding domain | 0.01807 | Inherited |
| Cu,Zn superoxide dismutase-like | 0.01807 | Inherited |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0.01807 | Inherited |
| Cell cycle transcription factor e2f-dp | 0.01807 | Inherited |
| LIM domain | 0.0253 | Inherited |
| Histone deacetylase, HDAC | 0.02615 | Inherited |
| Extended AAA-ATPase domain | 0.0273 | Inherited |
| WD40-repeat | 0.02841 | Inherited |
| Rhodopsin-like | 0.03334 | Inherited |
| Phosphate binding protein-like | 0.04242 | Inherited |
| Intermediate filament protein, coiled coil region | 0.04844 | Inherited |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.05006 | Inherited |
| Pyridoxal-dependent decarboxylase | 0.05447 | Inherited |
| Lamin A/C globular tail domain | 0.05447 | Inherited |
| Transforming growth factor (TGF)-beta | 0.06178 | Inherited |
| L30e/L7ae ribosomal proteins | 0.06178 | Inherited |
| DEP domain | 0.06178 | Inherited |
| Fibronectin type III | 0.0876 | Inherited |
| FKBP immunophilin/proline isomerase | 0.09534 | Inherited |
| Lipovitellin-phosvitin complex, superhelical domain | 0.1298 | Inherited |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.1298 | Inherited |
| SH3-domain | 0.1545 | Inherited |
| Motor proteins | 0.1666 | Inherited |
| Myosin rod fragments | 0.1787 | Inherited |
| Regulator of G-protein signaling, RGS | 0.2143 | Inherited |
| EGF-type module | 0.2354 | Inherited |
| Chromo domain | 0.2822 | Inherited |
| LDL receptor-like module | 0.6199 | Inherited |
| Protein kinases, catalytic subunit | 0.67 | Inherited |
| Ankyrin repeat | 0.8439 | Inherited |
| Integrin A (or I) domain | 0.8895 | Inherited |
| Voltage-gated potassium channels | 0.9774 | Inherited |
| Nuclear receptor | 1 | Inherited |
| Acetylcholinesterase-like | 1 | Inherited |
| Nuclear receptor ligand-binding domain | 1 | Inherited |
| C-type lectin domain | 1 | Inherited |
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Cytochrome P450 | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Multidrug efflux transporter AcrB transmembrane domain | 0.00000000000007697 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0.0000000000004498 | DIRECT |
| HSP20-like chaperones | 0.000000000007709 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0.00000000001941 | DIRECT |
| Histone-fold | 0.0000000001138 | DIRECT |
| Periplasmic binding protein-like I | 0.000000001215 | DIRECT |
| Nucleotide cyclase | 0.000000003581 | DIRECT |
| Insulin-like | 0.00000000671 | DIRECT |
| ARM repeat | 0.0000002313 | DIRECT |
| TPR-like | 0.0000006688 | DIRECT |
| Band 7/SPFH domain | 0.000002754 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.000003851 | DIRECT |
| Bromodomain | 0.000004345 | DIRECT |
| Actin-like ATPase domain | 0.00001138 | DIRECT |
| GroEL equatorial domain-like | 0.00001514 | DIRECT |
| GroEL-intermediate domain like | 0.00001514 | DIRECT |
| Sm-like ribonucleoproteins | 0.00001827 | DIRECT |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.00001898 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0.00002137 | DIRECT |
| Tubulin C-terminal domain-like | 0.00005336 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0.000088 | DIRECT |
| GroEL apical domain-like | 0.0001096 | DIRECT |
| PH domain-like | 0.0001356 | DIRECT |
| SNF-like | 0.0001526 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0.0001526 | DIRECT |
| SMAD/FHA domain | 0.0002308 | DIRECT |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.0002889 | DIRECT |
| Growth factor receptor domain | 0.0003633 | DIRECT |
| Tropomyosin | 0.0004383 | DIRECT |
| Class II aaRS and biotin synthetases | 0.000696 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.0007516 | DIRECT |
| Cysteine-rich domain | 0.00111 | INHERITED FROM: eating variant || odorant chemosensory response variant || thermosensory behavior variant || thermotaxis variant || odorant positive chemotaxis variant || positive chemotaxis variant |
| Prefoldin | 0.001184 | INHERITED FROM: locomotion variant |
| Hedgehog/intein (Hint) domain | 0.001322 | INHERITED FROM: locomotion variant || movement variant |
| NAD(P)-linked oxidoreductase | 0.002565 | INHERITED FROM: defecation cycle variant || defecation variant |
| Nucleic acid-binding proteins | 0.002669 | INHERITED FROM: avoids bacterial lawn |
| F1F0 ATP synthase subunit C | 0.002711 | INHERITED FROM: avoids bacterial lawn |
| ARID-like | 0.002711 | INHERITED FROM: organism UV hypersensitive || organism UV response variant || light response variant |
| Frizzled cysteine-rich domain | 0.002711 | INHERITED FROM: body muscle dystrophy || organism region behavior variant || organism segment behavior variant || body behavior variant |
| S15/NS1 RNA-binding domain | 0.002711 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| Spectrin repeat | 0.003545 | INHERITED FROM: locomotion variant || movement variant |
| Zn-binding ribosomal proteins | 0.00376 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| cAMP-binding domain-like | 0.006302 | INHERITED FROM: benzaldehyde chemotaxis variant || head movement variant || forward point velocity variant || sodium chloride chemotaxis variant || backward point velocity variant || odorant chemosensory response variant || butanone chemotaxis variant || chemosensory behavior variant || amplitude of sinusoidal movement variant || directionality variant || thermosensory behavior variant || positive chemotaxis defective || body posture wavelength variant || frequency of body bend variant || male mating defective || coiling variant || benzaldehyde chemotaxis defective || male mating variant || bloated || turning frequency variant || head bend angle variant || odorant negative chemotaxis defective || body bend variant || egg laying defective || sinusoidal movement variant || thermotaxis variant || body posture amplitude variant || chemotaxis variant || coiling frequency variant || nose movement variant || sodium chloride chemotaxis defective || odorant positive chemotaxis variant || path curvature variant || turning variant || positive chemotaxis variant || odorant positive chemotaxis defective || roller |
| EGF/Laminin | 0.00776 | INHERITED FROM: locomotion variant || odorant negative chemotaxis defective || movement variant || octanol chemotaxis defective || octanol chemotaxis variant |
| Translation proteins SH3-like domain | 0.007803 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| Integrin domains | 0.009579 | INHERITED FROM: egg laying variant |
| E2F-DP heterodimerization region | 0.009579 | INHERITED FROM: backward locomotion variant || locomotor coordination variant || directionality variant || reversal variant |
| Cu,Zn superoxide dismutase-like | 0.009579 | INHERITED FROM: defecation cycle variant || defecation variant || defecation cycle variable length |
| PYP-like sensor domain (PAS domain) | 0.01092 | INHERITED FROM: egg laying variant || egg laying defective |
| WD40 repeat-like | 0.0133 | INHERITED FROM: osmotic avoidance variant |
| PLC-like phosphodiesterases | 0.01491 | INHERITED FROM: sexually dimorphic behavior variant || defecation contraction variant || spicule insertion defective || posterior body wall contraction defecation cycle variant || copulation variant || male mating defective || male mating variant || defecation variant || ovulation variant |
| Fibronectin type III | 0.01533 | INHERITED FROM: locomotion reduced || body posture variant || path curvature increased || reversal variant || forward locomotion decreased |
| Lamin A/C globular tail domain | 0.01905 | INHERITED FROM: paralyzed |
| Intermediate filament protein, coiled coil region | 0.01905 | INHERITED FROM: paralyzed |
| Arginase/deacetylase | 0.02405 | INHERITED FROM: organism UV hypersensitive || organism UV response variant || light response variant |
| SH3-domain | 0.02474 | INHERITED FROM: ovulation variant |
| FYVE/PHD zinc finger | 0.02548 | INHERITED FROM: organism UV hypersensitive || organism UV response variant || light response variant |
| beta-beta-alpha zinc fingers | 0.03866 | INHERITED FROM: egg laying serotonin resistant || egg laying imipramine resistant |
| Periplasmic binding protein-like II | 0.04116 | INHERITED FROM: eating variant || sodium chloride chemotaxis variant || pharyngeal pumping rate variant || chemosensory behavior variant || aqueous positive chemotaxis defective || thermosensory behavior variant || positive chemotaxis defective || chemosensory response variant || thermotaxis variant || pharyngeal pumping reduced || chemotaxis variant || aqueous positive chemotaxis variant || sodium chloride chemotaxis defective |
| Ligand-binding domain in the NO signalling and Golgi transport | 0.0445 | INHERITED FROM: eating variant || induced pharyngeal pumping variant || pharyngeal pumping rate variant |
| FKBP-like | 0.0445 | INHERITED FROM: dauer behavior variant || postembryonic behavior variant || developmental behavior variant |
| HD-domain/PDEase-like | 0.0445 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
| DNA/RNA polymerases | 0.05476 | INHERITED FROM: organism UV hypersensitive || organism UV response variant || light response variant |
| Class II aaRS ABD-related | 0.05837 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.07315 | INHERITED FROM: avoids bacterial lawn |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.07592 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| Lipovitellin-phosvitin complex, superhelical domain | 0.07592 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| PDZ domain-like | 0.07675 | INHERITED FROM: body muscle dystrophy || organism region behavior variant || organism segment behavior variant || body behavior variant || ovulation variant |
| NTF2-like | 0.08971 | INHERITED FROM: sexually dimorphic behavior variant || copulation variant || male mating defective || male mating variant |
| Nucleotidylyl transferase | 0.09068 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.09808 | INHERITED FROM: avoids bacterial lawn |
| L30e-like | 0.09808 | INHERITED FROM: avoids bacterial lawn |
| Myosin rod fragments | 0.09808 | INHERITED FROM: sluggish |
| Regulator of G-protein signaling, RGS | 0.1184 | INHERITED FROM: negative chemotaxis variant || mechanosensation variant || chemotaxis variant |
| Glutathione synthetase ATP-binding domain-like | 0.1509 | INHERITED FROM: sexually dimorphic behavior variant || chemosensory behavior variant || copulation variant || male mating variant || negative chemotaxis variant || male mating efficiency reduced || chemotaxis variant || osmotic avoidance variant |
| EF-hand | 0.1742 | INHERITED FROM: defecation contraction variant || ovulation variant |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0.1875 | INHERITED FROM: defecation cycle variant || defecation variant |
| Acyl-CoA dehydrogenase NM domain-like | 0.1875 | INHERITED FROM: defecation cycle variant || defecation variant |
| Chromo domain-like | 0.1941 | INHERITED FROM: organism UV hypersensitive || organism UV response variant || light response variant |
| PLP-dependent transferases | 0.2736 | INHERITED FROM: expulsion variant || defecation contraction variant || forward point velocity increased || backward point velocity increased || path curvature decreased || body posture amplitude increased || forward locomotion increased |
| Ubiquitin-like | 0.3535 | INHERITED FROM: body muscle dystrophy || organism region behavior variant || organism segment behavior variant || body behavior variant |
| NAD kinase/diacylglycerol kinase-like | 0.3567 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
| LDL receptor-like module | 0.3851 | INHERITED FROM: paralyzed |
| Protein kinase-like (PK-like) | 0.4389 | INHERITED FROM: chemosensory behavior variant || body muscle dystrophy || alkaline pH chemotaxis variant || dauer behavior variant || dauer nictation behavior variant || aqueous chemosensory response variant || velocity of movement increased || organism region behavior variant || postembryonic behavior variant || organism segment behavior variant || octanol chemotaxis defective || egg laying response to food variant || mechanosensation variant || late stage egg laid || developmental behavior variant || positive chemotaxis variant |
| Ankyrin repeat | 0.4601 | INHERITED FROM: backward locomotion variant || head movement variant || localized movement variant || forward locomotion variant || tail bend angle variant || body posture variant || turning frequency variant || head bend angle variant || chemosensory response variant || odorant negative chemotaxis defective || body bend variant || sinusoidal movement variant || body posture wavelength decreased || reversal variant || octanol chemotaxis defective || chemotaxis variant || octanol chemotaxis variant || tail movement variant || nose movement variant || turning variant |
| FAD/NAD(P)-binding domain | 0.6514 | INHERITED FROM: fewer eggs laid |
| BPTI-like | 0.7151 | INHERITED FROM: male mating defective |
| Homeodomain-like | 0.7502 | INHERITED FROM: backward locomotion variant || quiescence variant || coiling variant || egg laying imipramine resistant || roaming reduced || forward locomotion decreased || coiling frequency variant || bag of worms || foraging reduced |
| Saposin | 0.7957 | INHERITED FROM: fewer eggs laid |
| RNA-binding domain, RBD | 0.828 | INHERITED FROM: locomotion variant || unfertilized oocytes laid |
| "Winged helix" DNA-binding domain | 0.8384 | INHERITED FROM: body muscle dystrophy || organism segment behavior variant || body behavior variant |
| Voltage-gated potassium channels | 0.8867 | INHERITED FROM: hyperactive egg laying || activity level variant || eating variant || backward locomotion variant || head movement variant || forward point velocity variant || localized movement variant || expulsion variant || forward locomotion variant || backward point velocity variant || spicule insertion defective || locomotor coordination variant || expulsion defective || tail bend angle variant || flaccid || positive chemotaxis defective || body posture variant || plate tap habituation variant || bloated || turning frequency variant || head bend angle variant || body bend variant || egg laying defective || habituation variant || mechanosensation variant || coiling frequency variant || bag of worms || roller |
| Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: solitary feeding increased |
| Immunoglobulin | 1 | INHERITED FROM: locomotion reduced || body posture variant || movement variant |
| Glucocorticoid receptor-like (DNA-binding domain) | 1 | INHERITED FROM: solitary feeding increased |
| C-type lectin-like | 1 | INHERITED FROM: sexually dimorphic behavior variant || copulation variant || male mating defective || male mating variant |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: induced pharyngeal pumping variant || serotonin induced pumping variant |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Cytochrome P450 | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Cytochrome c | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| Multidrug efflux transporter AcrB transmembrane domain | 0.00000000000007697 | Direct |
| Transducin (alpha subunit), insertion domain | 0.0000000000004498 | Direct |
| HSP20-like chaperones | 0.000000000007709 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0.00000000001941 | Direct |
| Histone-fold | 0.0000000001138 | Direct |
| Periplasmic binding protein-like I | 0.000000001215 | Direct |
| Nucleotide cyclase | 0.000000003581 | Direct |
| Insulin-like | 0.00000000671 | Direct |
| ARM repeat | 0.0000002313 | Direct |
| TPR-like | 0.0000006688 | Direct |
| Band 7/SPFH domain | 0.000002754 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.000003851 | Direct |
| Bromodomain | 0.000004345 | Direct |
| Actin-like ATPase domain | 0.00001138 | Direct |
| GroEL equatorial domain-like | 0.00001514 | Direct |
| GroEL-intermediate domain like | 0.00001514 | Direct |
| Sm-like ribonucleoproteins | 0.00001827 | Direct |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.00001898 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0.00002137 | Direct |
| Tubulin C-terminal domain-like | 0.00005336 | Direct |
| Nicotinic receptor ligand binding domain-like | 0.000088 | Direct |
| GroEL apical domain-like | 0.0001096 | Direct |
| PH domain-like | 0.0001356 | Direct |
| SNF-like | 0.0001526 | Direct |
| Tubulin nucleotide-binding domain-like | 0.0001526 | Direct |
| SMAD/FHA domain | 0.0002308 | Direct |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.0002889 | Direct |
| Growth factor receptor domain | 0.0003633 | Direct |
| Tropomyosin | 0.0004383 | Direct |
| Class II aaRS and biotin synthetases | 0.000696 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.0007516 | Direct |
| Cysteine-rich domain | 0.00111 | Inherited |
| Prefoldin | 0.001184 | Inherited |
| Hedgehog/intein (Hint) domain | 0.001322 | Inherited |
| NAD(P)-linked oxidoreductase | 0.002565 | Inherited |
| Nucleic acid-binding proteins | 0.002669 | Inherited |
| F1F0 ATP synthase subunit C | 0.002711 | Inherited |
| ARID-like | 0.002711 | Inherited |
| Frizzled cysteine-rich domain | 0.002711 | Inherited |
| S15/NS1 RNA-binding domain | 0.002711 | Inherited |
| Spectrin repeat | 0.003545 | Inherited |
| Zn-binding ribosomal proteins | 0.00376 | Inherited |
| cAMP-binding domain-like | 0.006302 | Inherited |
| EGF/Laminin | 0.00776 | Inherited |
| Translation proteins SH3-like domain | 0.007803 | Inherited |
| Integrin domains | 0.009579 | Inherited |
| E2F-DP heterodimerization region | 0.009579 | Inherited |
| Cu,Zn superoxide dismutase-like | 0.009579 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.01092 | Inherited |
| WD40 repeat-like | 0.0133 | Inherited |
| PLC-like phosphodiesterases | 0.01491 | Inherited |
| Fibronectin type III | 0.01533 | Inherited |
| Lamin A/C globular tail domain | 0.01905 | Inherited |
| Intermediate filament protein, coiled coil region | 0.01905 | Inherited |
| Arginase/deacetylase | 0.02405 | Inherited |
| SH3-domain | 0.02474 | Inherited |
| FYVE/PHD zinc finger | 0.02548 | Inherited |
| beta-beta-alpha zinc fingers | 0.03866 | Inherited |
| Periplasmic binding protein-like II | 0.04116 | Inherited |
| Ligand-binding domain in the NO signalling and Golgi transport | 0.0445 | Inherited |
| FKBP-like | 0.0445 | Inherited |
| HD-domain/PDEase-like | 0.0445 | Inherited |
| DNA/RNA polymerases | 0.05476 | Inherited |
| Class II aaRS ABD-related | 0.05837 | Inherited |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.07315 | Inherited |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.07592 | Inherited |
| Lipovitellin-phosvitin complex, superhelical domain | 0.07592 | Inherited |
| PDZ domain-like | 0.07675 | Inherited |
| NTF2-like | 0.08971 | Inherited |
| Nucleotidylyl transferase | 0.09068 | Inherited |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.09808 | Inherited |
| L30e-like | 0.09808 | Inherited |
| Myosin rod fragments | 0.09808 | Inherited |
| Regulator of G-protein signaling, RGS | 0.1184 | Inherited |
| Glutathione synthetase ATP-binding domain-like | 0.1509 | Inherited |
| EF-hand | 0.1742 | Inherited |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0.1875 | Inherited |
| Acyl-CoA dehydrogenase NM domain-like | 0.1875 | Inherited |
| Chromo domain-like | 0.1941 | Inherited |
| PLP-dependent transferases | 0.2736 | Inherited |
| Ubiquitin-like | 0.3535 | Inherited |
| NAD kinase/diacylglycerol kinase-like | 0.3567 | Inherited |
| LDL receptor-like module | 0.3851 | Inherited |
| Protein kinase-like (PK-like) | 0.4389 | Inherited |
| Ankyrin repeat | 0.4601 | Inherited |
| FAD/NAD(P)-binding domain | 0.6514 | Inherited |
| BPTI-like | 0.7151 | Inherited |
| Homeodomain-like | 0.7502 | Inherited |
| Saposin | 0.7957 | Inherited |
| RNA-binding domain, RBD | 0.828 | Inherited |
| "Winged helix" DNA-binding domain | 0.8384 | Inherited |
| Voltage-gated potassium channels | 0.8867 | Inherited |
| Nuclear receptor ligand-binding domain | 1 | Inherited |
| Immunoglobulin | 1 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 1 | Inherited |
| C-type lectin-like | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0 | DIRECT |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0 | DIRECT |
81383,50978
81383 - F-box domain
50978 - WD40 repeat-like | 0 | DIRECT |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | DIRECT |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | DIRECT |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0000000000004498 | DIRECT |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.0000002329 | DIRECT |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.000003851 | DIRECT |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.000004564 | DIRECT |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.000006509 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.00001514 | DIRECT |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.00001514 | DIRECT |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.0001526 | DIRECT |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.0002061 | DIRECT |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.0002061 | DIRECT |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.0002308 | DIRECT |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.0003299 | DIRECT |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0.001004 | INHERITED FROM: locomotion variant |
56112,55073
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0.001347 | INHERITED FROM: cation positive chemotaxis defective || AWC odorant chemotaxis variant || benzaldehyde chemotaxis variant || AWC odorant chemotaxis defective || chemosensory behavior variant || lithium chemotaxis defective || alkaline pH chemotaxis variant || aqueous chemosensory response variant || iodide chemotaxis defective || bromide chemotaxis defective || chemosensory response variant || bromide chemotaxis variant || anion positive chemotaxis defective || chemotaxis variant || anion positive chemotaxis variant || magnesium chemotaxis defective || positive chemotaxis variant || iodide chemotaxis variant || cation positive chemotaxis variant |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.002711 | INHERITED FROM: organism UV hypersensitive || organism UV response variant || light response variant |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0.002711 | INHERITED FROM: dauer behavior variant || postembryonic behavior variant || developmental behavior variant |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.003069 | INHERITED FROM: expulsion variant || defecation contraction variant || defecation variant |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.003069 | INHERITED FROM: eating variant |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0.00376 | INHERITED FROM: locomotion reduced || paralyzed |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.003869 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.009014 | INHERITED FROM: backward locomotion variant || head movement variant || forward point velocity variant || backward point velocity variant || locomotor coordination variant || tail bend angle variant || body posture amplitude decreased || amplitude of sinusoidal movement variant || locomotion reduced || body posture variant || turning frequency variant || head bend angle variant || egg laying defective || movement variant || reversal variant || forward locomotion decreased || tail movement variant || nose movement variant || turning variant |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0.009579 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.009579 | INHERITED FROM: organism UV hypersensitive || organism UV response variant || light response variant |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0.02405 | INHERITED FROM: backward locomotion variant || head movement variant || forward point velocity variant || localized movement variant || forward locomotion variant || backward point velocity variant || tail bend angle variant || velocity of movement variant || amplitude of sinusoidal movement variant || directionality variant || backing decreased || body posture variant || frequency of body bend variant || coiling variant || turning frequency variant || head bend angle variant || body bend variant || coiling frequency increased || pausing variant || sinusoidal movement variant || body posture amplitude variant || reversal variant || tail movement variant || coiling frequency variant || nose movement variant || path curvature variant || turning variant |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0.02959 | INHERITED FROM: organism UV hypersensitive || organism UV response variant || light response variant |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.03393 | INHERITED FROM: body bend variant || sinusoidal movement variant |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0.03437 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0.07592 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
48431,56968
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.07592 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.1539 | INHERITED FROM: odorant chemosensory response variant || aqueous positive chemotaxis defective || positive chemotaxis defective || aqueous chemosensory response variant || negative chemotaxis variant || mechanosensation variant || chemotaxis variant || aqueous positive chemotaxis variant || osmotic avoidance variant || positive chemotaxis variant |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.1875 | INHERITED FROM: defecation cycle variant || defecation variant |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.2044 | INHERITED FROM: paralyzed |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 1 | INHERITED FROM: backward locomotion variant || head movement variant || forward point velocity variant || backward point velocity variant || locomotor coordination variant || tail bend angle variant || amplitude of sinusoidal movement variant || locomotion reduced || body posture variant || turning frequency variant || head bend angle variant || body bend variant || path curvature increased || reversal variant || tail movement variant || nose movement variant || turning variant |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | Direct |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0 | Direct |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0 | Direct |
81383,50978
81383 - F-box domain
50978 - WD40 repeat-like | 0 | Direct |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | Direct |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | Direct |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0000000000004498 | Direct |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.0000002329 | Direct |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.000003851 | Direct |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.000004564 | Direct |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.000006509 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.00001514 | Direct |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.00001514 | Direct |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.0001526 | Direct |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.0002061 | Direct |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.0002061 | Direct |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.0002308 | Direct |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.0003299 | Direct |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0.001004 | Inherited |
56112,55073
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0.001347 | Inherited |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.002711 | Inherited |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0.002711 | Inherited |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.003069 | Inherited |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.003069 | Inherited |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0.00376 | Inherited |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.003869 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.009014 | Inherited |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0.009579 | Inherited |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.009579 | Inherited |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0.02405 | Inherited |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0.02959 | Inherited |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.03393 | Inherited |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0.03437 | Inherited |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0.07592 | Inherited |
48431,56968
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.07592 | Inherited |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.1539 | Inherited |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.1875 | Inherited |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.2044 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
57362,57362,57362
57362 - BPTI-like
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | DIRECT |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
55973,55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | DIRECT |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.00001514 | DIRECT |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.0002061 | DIRECT |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.0004256 | DIRECT |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.003869 | INHERITED FROM: locomotion reduced || locomotion variant || movement variant |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.009428 | INHERITED FROM: locomotion reduced || body posture variant || egg laying defective || movement variant |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.009579 | INHERITED FROM: organism UV hypersensitive || organism UV response variant || light response variant |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.009579 | INHERITED FROM: organism UV hypersensitive || organism UV response variant || light response variant |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.0103 | INHERITED FROM: backward locomotion variant || head movement variant || forward point velocity variant || backward point velocity variant || tail bend angle variant || body posture amplitude decreased || amplitude of sinusoidal movement variant || locomotion reduced || body posture variant || turning frequency variant || head bend angle variant || body bend variant || movement variant || body posture wavelength decreased || reversal variant || tail movement variant || nose movement variant || turning variant |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.07315 | INHERITED FROM: paralyzed |
56968,48431,56968
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.07592 | INHERITED FROM: avoids bacterial lawn || feeding behavior variant |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
57362,57362,57362
57362 - BPTI-like
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | Direct |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
55973,55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | Direct |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.00001514 | Direct |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.0002061 | Direct |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.0004256 | Direct |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.003869 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.009428 | Inherited |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.009579 | Inherited |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.009579 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.0103 | Inherited |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.07315 | Inherited |
56968,48431,56968
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0.07592 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
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