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Worm Phenotype (WP): cell development variant
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this WP term (SDWP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| POU-specific domain | 0 | DIRECT |
| RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| Laminin-type module | 0 | DIRECT |
| La domain | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| WWE domain | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| Diap1 N-terninal region-like | 0 | DIRECT |
| RNA-polymerase beta | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
| Proteasome subunits | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| Frizzled cysteine-rich domain | 0 | DIRECT |
| Trunk domain of Sec23/24 | 0 | DIRECT |
| Troponin I | 0 | DIRECT |
| Gelsolin-like | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Skp1 dimerisation domain-like | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Canonical RBD | 0.000000000003364 | DIRECT |
| G proteins | 0.000000001781 | DIRECT |
| Homeodomain | 0.000000002362 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.000000006593 | DIRECT |
| RING finger domain, C3HC4 | 0.000000008661 | DIRECT |
| UBC-related | 0.000000241 | DIRECT |
| Motor proteins | 0.000006908 | DIRECT |
| Hect, E3 ligase catalytic domain | 0.000008235 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0.000008235 | DIRECT |
| BTB/POZ domain | 0.00001219 | DIRECT |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.00002286 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0.00003028 | DIRECT |
| BCR-homology GTPase activation domain (BH-domain) | 0.00004823 | DIRECT |
| Pumilio repeat | 0.00006127 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.00006127 | DIRECT |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.00006776 | DIRECT |
| B-box zinc-binding domain | 0.00006776 | DIRECT |
| WD40-repeat | 0.00007577 | DIRECT |
| Extended AAA-ATPase domain | 0.0001444 | DIRECT |
| I set domains | 0.0001617 | DIRECT |
| PDZ domain | 0.0002924 | DIRECT |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.0004393 | DIRECT |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.0004937 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0.0004937 | DIRECT |
| SMAD MH1 domain | 0.0004937 | DIRECT |
| RecA protein-like (ATPase-domain) | 0.0004937 | DIRECT |
| SMAD domain | 0.00075 | DIRECT |
| Reprolysin-like | 0.00075 | DIRECT |
| Armadillo repeat | 0.0007531 | DIRECT |
| Actin/HSP70 | 0.0009519 | DIRECT |
| L30e/L7ae ribosomal proteins | 0.001895 | INHERITED FROM: germ cell differentiation variant || meiotic progression during oogenesis variant || diplotene progression during oogenesis variant || meiosis variant || diplotene region organization variant || oocyte number decreased || pachytene progression during oogenesis variant || meiotic progression prophase variant || oogenesis variant || pachytene region organization variant |
| Myotubularin-like phosphatases | 0.001895 | INHERITED FROM: neuron migration variant || Q neuroblast lineage migration variant |
| Sema domain | 0.001895 | INHERITED FROM: axon guidance variant || axon outgrowth variant || neuronal outgrowth variant || neuron development variant |
| Laminin G-like module | 0.002216 | INHERITED FROM: axon guidance variant || commissure handedness defective || axon outgrowth variant || neuronal outgrowth variant |
| HMG-box | 0.002253 | INHERITED FROM: postembryonic cell lineage variant |
| Classic zinc finger, C2H2 | 0.002517 | INHERITED FROM: lineage variant |
| Erythroid transcription factor GATA-1 | 0.002518 | INHERITED FROM: lineage variant |
| Clathrin coat assembly domain | 0.002545 | INHERITED FROM: gut granule development variant || intestinal cell development variant || gut granule biogenesis reduced |
| Cullin homology domain | 0.002545 | INHERITED FROM: oogenesis variant |
| Fibronectin type III | 0.003011 | INHERITED FROM: body wall cell development variant || muscle arm development variant || muscle arm development defective || muscle cell development variant || axon outgrowth variant || neuron development variant |
| Tubulin, C-terminal domain | 0.005452 | INHERITED FROM: cell migration variant || axon outgrowth variant || distal tip cell migration variant || neuronal outgrowth variant |
| Double-stranded RNA-binding domain (dsRBD) | 0.006279 | INHERITED FROM: dendrite development variant || dendritic termini number reduced || neurite development variant |
| Cdc48 domain 2-like | 0.00718 | INHERITED FROM: gametogenesis variant || meiosis variant || germ cell development variant |
| Anticodon-binding domain | 0.00718 | INHERITED FROM: germ cell differentiation variant || cell differentiation variant || gametogenesis variant || meiotic progression during oogenesis variant || diplotene progression during oogenesis variant || meiosis variant || diplotene region organization variant || oocyte number decreased || pachytene progression during oogenesis variant || meiotic progression prophase variant || oogenesis variant || pachytene region organization variant || germ cell development variant |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0.00718 | INHERITED FROM: neuron migration variant || cell migration variant || Q neuroblast lineage migration variant |
| Cell cycle transcription factor e2f-dp | 0.00718 | INHERITED FROM: vulva cell fate specification variant || vulval cell induction variant || cell fate specification variant || multivulva || vulval cell induction increased |
| Cdc48 N-terminal domain-like | 0.00718 | INHERITED FROM: gametogenesis variant || meiosis variant || germ cell development variant |
| Growth factor receptor domain | 0.007314 | INHERITED FROM: axon guidance variant || body wall cell development variant || neuronal cell fate specification variant || loss of asymmetry ASE || muscle arm development variant || muscle arm development defective || muscle cell development variant || loss of left right asymmetry |
| Retrovirus zinc finger-like domains | 0.007314 | INHERITED FROM: germline proliferation variant || cell proliferation increased |
| Plexin repeat | 0.008362 | INHERITED FROM: axon guidance variant || axon outgrowth variant || neuronal outgrowth variant || neuron development variant |
| Chromo domain | 0.009804 | INHERITED FROM: vulval cell induction variant || multivulva || vulval cell induction increased |
| PHD domain | 0.01083 | INHERITED FROM: vulval cell induction variant || cell fate specification variant || multivulva || vulval cell induction increased |
| Tandem AAA-ATPase domain | 0.01104 | INHERITED FROM: dendrite development variant || neurite development variant |
| Tubulin, GTPase domain | 0.01269 | INHERITED FROM: axon outgrowth variant || distal tip cell migration variant || neuronal outgrowth variant |
| CCCH zinc finger | 0.01282 | INHERITED FROM: oocyte meiotic maturation variant || embryonic cell lineage variant |
| Pleckstrin-homology domain (PH domain) | 0.01382 | INHERITED FROM: body wall cell development variant || muscle arm development variant || axon outgrowth variant |
| NHL repeat | 0.01715 | INHERITED FROM: Q neuroblast lineage migration variant |
| Protein kinases, catalytic subunit | 0.02131 | INHERITED FROM: pachytene arrested germline nuclei || muscle arm development variant || posterior reversed vulval lineage || muscle arm development defective || muscle cell development variant || axon outgrowth variant || loss of left right asymmetry || synapsis defective |
| Clathrin adaptor core protein | 0.02197 | INHERITED FROM: meiotic progression during oogenesis variant || diplotene progression during oogenesis variant || diplotene region organization variant || meiotic progression prophase variant || oogenesis variant |
| Cadherin | 0.02377 | INHERITED FROM: axon guidance variant || cell polarity variant || axon development variant || axon outgrowth variant || neuron development variant |
| DEP domain | 0.02667 | INHERITED FROM: cell polarity variant |
| F1F0 ATP synthase subunit C | 0.02667 | INHERITED FROM: germ cell differentiation variant || diakinesis progression during oogenesis variant || meiotic progression during oogenesis variant || meiosis variant || chromosome condensation variant || meiotic progression prophase variant || meiotic chromosome organization variant || oogenesis variant || oocytes lack nucleus |
| Bromodomain | 0.02835 | INHERITED FROM: vulvaless || vulval cell induction variant || cell fate specification variant || multivulva |
| Cyclin | 0.03132 | INHERITED FROM: no oocytes |
| Single strand DNA-binding domain, SSB | 0.03259 | INHERITED FROM: germ cell development variant |
| cAMP-binding domain | 0.03928 | INHERITED FROM: neuronal cell fate specification variant || loss of asymmetry ASE || loss of left right asymmetry |
| Translational machinery components | 0.04453 | INHERITED FROM: germ cell differentiation variant || meiotic progression during oogenesis variant || diplotene progression during oogenesis variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || oogenesis variant || pachytene region organization variant |
| Nitrogenase iron protein-like | 0.05463 | INHERITED FROM: diplotene progression during oogenesis variant || oocyte number decreased || chromosome condensation variant |
| First domain of FERM | 0.06048 | INHERITED FROM: cell migration variant |
| Histone lysine methyltransferases | 0.06242 | INHERITED FROM: vulval cell induction variant || cell fate specification variant || fewer germ cells || multivulva || vulval cell induction increased |
| Cold shock DNA-binding domain-like | 0.06244 | INHERITED FROM: germ cell differentiation variant || meiotic progression during oogenesis variant || diplotene progression during oogenesis variant || oocyte number decreased || pachytene progression during oogenesis variant || meiotic progression prophase variant || pachytene region organization variant || no oocytes |
| PX domain | 0.0836 | INHERITED FROM: neuron migration variant || Q neuroblast lineage migration variant || anterior neuron migration defective |
| Third domain of FERM | 0.1174 | INHERITED FROM: cell migration variant |
| FHA domain | 0.1194 | INHERITED FROM: axon branching variant || axon outgrowth variant || neuronal outgrowth variant |
| Calponin-homology domain, CH-domain | 0.1233 | INHERITED FROM: axon guidance variant |
| Eukaryotic type KH-domain (KH-domain type I) | 0.1501 | INHERITED FROM: dendritic termini number reduced |
| Myb/SANT domain | 0.1667 | INHERITED FROM: cell fate specification variant |
| TBP-associated factors, TAFs | 0.2226 | INHERITED FROM: vulva cell fate specification variant || vulval cell induction variant |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.234 | INHERITED FROM: meiotic progression during oogenesis variant || diplotene progression during oogenesis variant || oocyte number decreased || pachytene progression during oogenesis variant || meiotic progression prophase variant || diplotene absent during oogenesis || pachytene region organization variant |
| Tetratricopeptide repeat (TPR) | 0.2415 | INHERITED FROM: meiosis metaphase to anaphase transition block |
| Second domain of FERM | 0.2613 | INHERITED FROM: cell migration variant |
| Synaptotagmin-like (S variant) | 0.2613 | INHERITED FROM: synaptic transmission variant || presynaptic region physiology variant |
| Ubiquitin-related | 0.2655 | INHERITED FROM: no oocytes |
| Nucleosome core histones | 0.2698 | INHERITED FROM: gametogenesis variant || chromosome condensation variant || meiotic chromosome organization variant || diplotene absent during oogenesis || germ cell development variant |
| Insulin-like | 0.3599 | INHERITED FROM: body wall cell development variant || muscle arm development variant || muscle cell development variant |
| Elongation factors | 0.3731 | INHERITED FROM: meiotic progression during oogenesis variant || diplotene progression during oogenesis variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || oogenesis variant || pachytene region organization variant |
| Cysteine-rich DNA binding domain, (DM domain) | 0.3804 | INHERITED FROM: cell fusion variant |
| Voltage-gated potassium channels | 0.8487 | INHERITED FROM: neuronal cell fate specification variant || loss of asymmetry AWC || loss of left right asymmetry |
| ABC transporter ATPase domain-like | 0.8487 | INHERITED FROM: gut granule development variant || intestinal cell development variant || gut granule biogenesis reduced |
| MSP-like | 0.9211 | INHERITED FROM: cell migration variant || linker cell migration variant |
| ABC transporter transmembrane region | 0.9752 | INHERITED FROM: gut granule development variant || intestinal cell development variant || gut granule biogenesis reduced |
| Nicotinic receptor ligand binding domain-like | 1 | INHERITED FROM: synaptic transmission variant || acetylcholine synaptic transmission variant |
| Neurotransmitter-gated ion-channel transmembrane pore | 1 | INHERITED FROM: synaptic transmission variant || acetylcholine synaptic transmission variant |
| Protein serine/threonine phosphatase | 1 | INHERITED FROM: meiosis defective early emb |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| POU-specific domain | 0 | Direct |
| RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | Direct |
| Nop domain | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| Laminin-type module | 0 | Direct |
| La domain | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| WWE domain | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| Diap1 N-terninal region-like | 0 | Direct |
| RNA-polymerase beta | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Formin homology 2 domain (FH2 domain) | 0 | Direct |
| Proteasome subunits | 0 | Direct |
| LEM domain | 0 | Direct |
| Frizzled cysteine-rich domain | 0 | Direct |
| Trunk domain of Sec23/24 | 0 | Direct |
| Troponin I | 0 | Direct |
| Gelsolin-like | 0 | Direct |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | Direct |
| Integrin domains | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Skp1 dimerisation domain-like | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Canonical RBD | 0.000000000003364 | Direct |
| G proteins | 0.000000001781 | Direct |
| Homeodomain | 0.000000002362 | Direct |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.000000006593 | Direct |
| RING finger domain, C3HC4 | 0.000000008661 | Direct |
| UBC-related | 0.000000241 | Direct |
| Motor proteins | 0.000006908 | Direct |
| Hect, E3 ligase catalytic domain | 0.000008235 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0.000008235 | Direct |
| BTB/POZ domain | 0.00001219 | Direct |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.00002286 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0.00003028 | Direct |
| BCR-homology GTPase activation domain (BH-domain) | 0.00004823 | Direct |
| Pumilio repeat | 0.00006127 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.00006127 | Direct |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.00006776 | Direct |
| B-box zinc-binding domain | 0.00006776 | Direct |
| WD40-repeat | 0.00007577 | Direct |
| Extended AAA-ATPase domain | 0.0001444 | Direct |
| I set domains | 0.0001617 | Direct |
| PDZ domain | 0.0002924 | Direct |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.0004393 | Direct |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.0004937 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0.0004937 | Direct |
| SMAD MH1 domain | 0.0004937 | Direct |
| RecA protein-like (ATPase-domain) | 0.0004937 | Direct |
| SMAD domain | 0.00075 | Direct |
| Reprolysin-like | 0.00075 | Direct |
| Armadillo repeat | 0.0007531 | Direct |
| Actin/HSP70 | 0.0009519 | Direct |
| L30e/L7ae ribosomal proteins | 0.001895 | Inherited |
| Myotubularin-like phosphatases | 0.001895 | Inherited |
| Sema domain | 0.001895 | Inherited |
| Laminin G-like module | 0.002216 | Inherited |
| HMG-box | 0.002253 | Inherited |
| Classic zinc finger, C2H2 | 0.002517 | Inherited |
| Erythroid transcription factor GATA-1 | 0.002518 | Inherited |
| Clathrin coat assembly domain | 0.002545 | Inherited |
| Cullin homology domain | 0.002545 | Inherited |
| Fibronectin type III | 0.003011 | Inherited |
| Tubulin, C-terminal domain | 0.005452 | Inherited |
| Double-stranded RNA-binding domain (dsRBD) | 0.006279 | Inherited |
| Cdc48 domain 2-like | 0.00718 | Inherited |
| Anticodon-binding domain | 0.00718 | Inherited |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0.00718 | Inherited |
| Cell cycle transcription factor e2f-dp | 0.00718 | Inherited |
| Cdc48 N-terminal domain-like | 0.00718 | Inherited |
| Growth factor receptor domain | 0.007314 | Inherited |
| Retrovirus zinc finger-like domains | 0.007314 | Inherited |
| Plexin repeat | 0.008362 | Inherited |
| Chromo domain | 0.009804 | Inherited |
| PHD domain | 0.01083 | Inherited |
| Tandem AAA-ATPase domain | 0.01104 | Inherited |
| Tubulin, GTPase domain | 0.01269 | Inherited |
| CCCH zinc finger | 0.01282 | Inherited |
| Pleckstrin-homology domain (PH domain) | 0.01382 | Inherited |
| NHL repeat | 0.01715 | Inherited |
| Protein kinases, catalytic subunit | 0.02131 | Inherited |
| Clathrin adaptor core protein | 0.02197 | Inherited |
| Cadherin | 0.02377 | Inherited |
| DEP domain | 0.02667 | Inherited |
| F1F0 ATP synthase subunit C | 0.02667 | Inherited |
| Bromodomain | 0.02835 | Inherited |
| Cyclin | 0.03132 | Inherited |
| Single strand DNA-binding domain, SSB | 0.03259 | Inherited |
| cAMP-binding domain | 0.03928 | Inherited |
| Translational machinery components | 0.04453 | Inherited |
| Nitrogenase iron protein-like | 0.05463 | Inherited |
| First domain of FERM | 0.06048 | Inherited |
| Histone lysine methyltransferases | 0.06242 | Inherited |
| Cold shock DNA-binding domain-like | 0.06244 | Inherited |
| PX domain | 0.0836 | Inherited |
| Third domain of FERM | 0.1174 | Inherited |
| FHA domain | 0.1194 | Inherited |
| Calponin-homology domain, CH-domain | 0.1233 | Inherited |
| Eukaryotic type KH-domain (KH-domain type I) | 0.1501 | Inherited |
| Myb/SANT domain | 0.1667 | Inherited |
| TBP-associated factors, TAFs | 0.2226 | Inherited |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.234 | Inherited |
| Tetratricopeptide repeat (TPR) | 0.2415 | Inherited |
| Second domain of FERM | 0.2613 | Inherited |
| Synaptotagmin-like (S variant) | 0.2613 | Inherited |
| Ubiquitin-related | 0.2655 | Inherited |
| Nucleosome core histones | 0.2698 | Inherited |
| Insulin-like | 0.3599 | Inherited |
| Elongation factors | 0.3731 | Inherited |
| Cysteine-rich DNA binding domain, (DM domain) | 0.3804 | Inherited |
| Voltage-gated potassium channels | 0.8487 | Inherited |
| ABC transporter ATPase domain-like | 0.8487 | Inherited |
| MSP-like | 0.9211 | Inherited |
| ABC transporter transmembrane region | 0.9752 | Inherited |
| Nicotinic receptor ligand binding domain-like | 1 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 1 | Inherited |
| Protein serine/threonine phosphatase | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
(show details)
Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | DIRECT |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0 | DIRECT |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0 | DIRECT |
81383,50978
81383 - F-box domain
50978 - WD40 repeat-like | 0 | DIRECT |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57850,117839
57850 - RING/U-box
117839 - WWE domain | 0 | DIRECT |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.00000015 | DIRECT |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.000003527 | DIRECT |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.0001534 | DIRECT |
57850,57845
57850 - RING/U-box
57845 - B-box zinc-binding domain | 0.0002104 | DIRECT |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.0007664 | DIRECT |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.001267 | INHERITED FROM: meiotic progression during oogenesis variant || oocyte number decreased || cell differentiation variant || germ cell differentiation variant || pachytene region organization variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || meiosis variant |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.001317 | INHERITED FROM: loss of left right asymmetry || neuronal cell fate specification variant || cell polarity variant |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.001957 | INHERITED FROM: axon guidance variant || axon outgrowth variant || body wall cell development variant || muscle arm development defective || neuron development variant || muscle cell development variant || muscle arm development variant || axon fasciculation variant |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.002514 | INHERITED FROM: cell proliferation increased |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.003906 | INHERITED FROM: axon guidance variant || axon outgrowth variant || neuron development variant |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0.004526 | INHERITED FROM: meiotic progression during oogenesis variant || gametogenesis variant || germ cell differentiation variant || oogenesis variant || chromosome condensation variant || meiotic chromosome organization variant || diakinesis progression during oogenesis variant || meiotic progression prophase variant || germ cell development variant || meiosis variant || oocytes lack nucleus |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.004526 | INHERITED FROM: neuronal outgrowth variant || axon guidance variant || axon outgrowth variant || neuron development variant |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0.004526 | INHERITED FROM: cell differentiation variant |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0.004526 | INHERITED FROM: gametogenesis variant || germ cell development variant |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.005185 | INHERITED FROM: neuronal outgrowth variant || axon outgrowth variant || distal tip cell migration variant |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.006757 | INHERITED FROM: axon guidance variant || axon outgrowth variant || body wall cell development variant || muscle arm development defective || neuron development variant || presynaptic region physiology variant || muscle cell development variant || muscle arm development variant |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0.007826 | INHERITED FROM: germ cell development variant |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0.01282 | INHERITED FROM: vulva cell fate specification variant || vulval cell induction increased || vulval cell induction variant || multivulva |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0.01713 | INHERITED FROM: meiotic progression during oogenesis variant || diplotene progression during oogenesis variant || oocyte number decreased || cell differentiation variant || diplotene region organization variant || germ cell differentiation variant || oogenesis variant || pachytene region organization variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || meiosis variant |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0.02069 | INHERITED FROM: meiotic progression during oogenesis variant || diplotene progression during oogenesis variant || germ cell differentiation variant |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.03063 | INHERITED FROM: axon guidance variant || axon outgrowth variant || axon development variant || cell polarity variant || neuron development variant |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0.03086 | INHERITED FROM: cell fate transformation || oocyte meiotic maturation variant |
49599,54695
49599 - TRAF domain-like
54695 - POZ domain | 0.04409 | INHERITED FROM: gametogenesis variant || germ cell development variant |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0.0471 | INHERITED FROM: neurite development variant || dendrite development variant |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.06577 | INHERITED FROM: meiotic spindle defective early emb || meiotic spindle defective |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.07123 | INHERITED FROM: cell migration variant |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.09904 | INHERITED FROM: no oocytes |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.167 | INHERITED FROM: gut granule biogenesis reduced || intestinal cell development variant || gut granule development variant |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.167 | INHERITED FROM: meiotic progression during oogenesis variant || diplotene progression during oogenesis variant || diplotene absent during oogenesis || oocyte number decreased || pachytene region organization variant || pachytene progression during oogenesis variant || meiotic progression prophase variant |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.1944 | INHERITED FROM: vulva cell fate specification variant || vulval cell induction variant |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.2099 | INHERITED FROM: meiotic progression during oogenesis variant || diplotene progression during oogenesis variant || oogenesis variant || pachytene region organization variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || meiosis variant |
81296,81296
81296 - E set domains
81296 - E set domains | 0.8768 | INHERITED FROM: axon guidance variant |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.957 | INHERITED FROM: gut granule biogenesis reduced || intestinal cell development variant || gut granule development variant |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 1 | INHERITED FROM: synaptic transmission variant |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | Direct |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0 | Direct |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0 | Direct |
81383,50978
81383 - F-box domain
50978 - WD40 repeat-like | 0 | Direct |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57850,117839
57850 - RING/U-box
117839 - WWE domain | 0 | Direct |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0 | Direct |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.00000015 | Direct |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.000003527 | Direct |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.0001534 | Direct |
57850,57845
57850 - RING/U-box
57845 - B-box zinc-binding domain | 0.0002104 | Direct |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.0007664 | Direct |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.001267 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.001317 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.001957 | Inherited |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.002514 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.003906 | Inherited |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0.004526 | Inherited |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.004526 | Inherited |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0.004526 | Inherited |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0.004526 | Inherited |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.005185 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.006757 | Inherited |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0.007826 | Inherited |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0.01282 | Inherited |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0.01713 | Inherited |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0.02069 | Inherited |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.03063 | Inherited |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0.03086 | Inherited |
49599,54695
49599 - TRAF domain-like
54695 - POZ domain | 0.04409 | Inherited |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0.0471 | Inherited |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.06577 | Inherited |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.07123 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.09904 | Inherited |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.167 | Inherited |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.167 | Inherited |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.1944 | Inherited |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.2099 | Inherited |
81296,81296
81296 - E set domains
81296 - E set domains | 0.8768 | Inherited |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.957 | Inherited |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.0004932 | DIRECT |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.002938 | INHERITED FROM: axon guidance variant || axon outgrowth variant || neuron development variant || dendrite development variant |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0.004526 | INHERITED FROM: neuronal outgrowth variant || axon guidance variant || axon outgrowth variant || neuron development variant |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.00596 | INHERITED FROM: presynaptic vesicle cluster variant || axon guidance variant || axon outgrowth variant || neuron development variant || presynaptic region physiology variant || axon fasciculation variant |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.03063 | INHERITED FROM: axon guidance variant || axon outgrowth variant || axon development variant || cell polarity variant || neuron development variant |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0.1489 | INHERITED FROM: cell migration variant |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.167 | INHERITED FROM: gut granule biogenesis reduced || intestinal cell development variant || gut granule development variant |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.167 | INHERITED FROM: gut granule biogenesis reduced || intestinal cell development variant || gut granule development variant |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.167 | INHERITED FROM: meiotic progression during oogenesis variant || diplotene progression during oogenesis variant || diplotene absent during oogenesis || oocyte number decreased || pachytene region organization variant || pachytene progression during oogenesis variant || meiotic progression prophase variant |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.0004932 | Direct |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.002938 | Inherited |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0.004526 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.00596 | Inherited |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.03063 | Inherited |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0.1489 | Inherited |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.167 | Inherited |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.167 | Inherited |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.167 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
|
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
