Worm Phenotype (WP): cell morphology variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children)	WP term [WP ID] <#Children>	(#SF|#FA)	#Supra-domain (Single|Duplex|Triple)
+ + 2:	Variant [WBPhenotype:0000886] <2>
+ 1:	morphology variant [WBPhenotype:0000520] <5>	(443|528)	(444|229|63)
0:	cell morphology variant [WBPhenotype:0000533] <10>	(104|103)	(106|55|17)
- 1:	cell component morphology variant [WBPhenotype:0002089] <17>	(84|85)	(84|42|9)
- 1:	cell type morphology variant [WBPhenotype:0002108] <12>	(77|76)	(79|45|15)
- 1:	cell component localization variant [WBPhenotype:0002098] <8>	(22|24)	(23|12|3)
- 1:	cell position defective [WBPhenotype:0002402] <2>	(1|0)	(1|0|0)
- 1:	accessory cell morphology variant [WBPhenotype:0000969] <1>	(0|0)	(0|0|0)
- 1:	cell cell contacts abnormal [WBPhenotype:0002404] <1>	(2|1)	(2|0|0)
- 1:	excretory cell morphology variant [WBPhenotype:0000916] <1>	(2|2)	(2|1|0)
- 1:	cell pigmentation variant [WBPhenotype:0000526]	(0|0)	(0|0|0)
- 1:	cell size decreased [WBPhenotype:0002025]	(0|0)	(0|0|0)
- 1:	coelomocyte morphology variant [WBPhenotype:0000911]	(0|0)	(0|0|0)

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Superfamily

Superfamily domains annotated to this WP term (SDWP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Helical domain of Sec23/24	0	DIRECT
P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
LEM domain	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
14-3-3 protein	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
ARM repeat	0	DIRECT
GroEL apical domain-like	0	DIRECT
Integrin domains	0	DIRECT
Histone-fold	0.0000000000005317	DIRECT
WD40 repeat-like	0.00000000001444	DIRECT
PH domain-like	0.000000004186	DIRECT
GTPase activation domain, GAP	0.000000009049	DIRECT
Skp1 dimerisation domain-like	0.0000000122	DIRECT
Calponin-homology domain, CH-domain	0.00000003255	DIRECT
Tubulin C-terminal domain-like	0.0000002103	DIRECT
Sm-like ribonucleoproteins	0.0000007545	DIRECT
Tubulin nucleotide-binding domain-like	0.0000008514	DIRECT
SNARE-like	0.0000008533	DIRECT
t-snare proteins	0.000001753	DIRECT
SH3-domain	0.000002652	DIRECT
Fibronectin type III	0.000003812	DIRECT
TPR-like	0.000004634	DIRECT
C2 domain (Calcium/lipid-binding domain, CaLB)	0.00001669	DIRECT
Tropomyosin	0.00005946	DIRECT
Immunoglobulin	0.0001393	DIRECT
Class II aaRS and biotin synthetases	0.0002224	DIRECT
Prefoldin	0.0002526	DIRECT
Troponin coil-coiled subunits	0.0002526	DIRECT
Actin-like ATPase domain	0.0002571	DIRECT
Ubiquitin-like	0.0003729	DIRECT
RNA-binding domain, RBD	0.0004276	DIRECT
SNARE fusion complex	0.0004585	DIRECT
Intermediate filament protein, coiled coil region	0.00067	DIRECT
Spectrin repeat	0.00067	DIRECT
Lamin A/C globular tail domain	0.00067	DIRECT
"Winged helix" DNA-binding domain	0.0007448	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.0007526	DIRECT
Trimeric LpxA-like enzymes	0.0007843	DIRECT
Nucleic acid-binding proteins	0.0008259	DIRECT
Ribosomal proteins S24e, L23 and L15e	0.0009049	DIRECT
ValRS/IleRS/LeuRS editing domain	0.0009049	DIRECT
Translation proteins SH3-like domain	0.001292	INHERITED FROM: germ cell morphology variant || oocyte number decreased || cell membrane organization biogenesis variant || cell type morphology variant || germ cell compartment expansion variant || cell component morphology variant
Cysteine-rich domain	0.002204	INHERITED FROM: germ cell partition morphology variant || mitochondria alignment variant || cell type morphology variant || body wall muscle sarcomere morphology variant || axon morphology variant || striated muscle morphology variant
Calpain large subunit, middle domain (domain III)	0.003217	INHERITED FROM: mitochondria morphology variant || cell type morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant || cell component morphology variant || striated muscle morphology variant
Class II aaRS ABD-related	0.003217	INHERITED FROM: germ cell morphology variant || cell type morphology variant || cytoplasmic processing body variant || cell component morphology variant
Riboflavin synthase domain-like	0.003217	INHERITED FROM: endosome morphology variant || lysosome-related organelle morphology variant || vesicle morphology variant || vesicle organization variant || recycling endosome morphology variant || cell component morphology variant
Activating enzymes of the ubiquitin-like proteins	0.003217	INHERITED FROM: germ cell morphology variant || germ cell compartment nuclei number variant || cell component morphology variant
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.003217	INHERITED FROM: endosome morphology variant || lysosome-related organelle morphology variant || vesicle morphology variant || vesicle organization variant || recycling endosome morphology variant || cell component morphology variant
Annexin	0.004124	INHERITED FROM: germ cell morphology variant
ADC-like	0.004124	INHERITED FROM: germ cell cytoplasmic morphology variant || germ cell morphology variant || cytoplasmic processing body variant || endoplasmic reticulum morphology variant || cell organization biogenesis variant
Cdc48 domain 2-like	0.004124	INHERITED FROM: germ cell cytoplasmic morphology variant || germ cell morphology variant || cytoplasmic processing body variant || endoplasmic reticulum morphology variant || cell organization biogenesis variant
beta-sandwich domain of Sec23/24	0.004124	INHERITED FROM: nuclear positioning variant || germ cell compartment morphology variant || germ cell morphology variant || oocyte morphology variant || germ cell compartment expansion variant || germline nuclear positioning variant || organelle organization biogenesis variant || cell organization biogenesis variant || germ cell compartment size variant
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.004174	INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || oocyte morphology variant || germ cell compartment expansion variant || germline nuclear positioning variant || nuclei enlarged
Growth factor receptor domain	0.005774	INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant
dsRNA-binding domain-like	0.008419	INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant
PDZ domain-like	0.009595	INHERITED FROM: cell membrane morphology variant || synapse morphology variant || actin organization biogenesis variant || endomitotic oocytes || cell junction variant
Metal cation-transporting ATPase, ATP-binding domain N	0.009681	INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant
Zn-binding ribosomal proteins	0.009762	INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant
DBL homology domain (DH-domain)	0.01009	INHERITED FROM: mitochondria alignment variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant || striated muscle morphology variant
Protein kinase-like (PK-like)	0.01112	INHERITED FROM: mitochondria alignment variant || myopodia present || mitochondrial content variant || muscle cell morphology variant
HAD-like	0.01223	INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant
Translation proteins	0.01286	INHERITED FROM: germ cell morphology variant || germ cell compartment expansion variant
S15/NS1 RNA-binding domain	0.01394	INHERITED FROM: germ cell compartment morphology variant || germ cell morphology variant || oocyte morphology variant || germ cell compartment expansion variant
Calcium ATPase, transmembrane domain M	0.0141	INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant
EGF/Laminin	0.01459	INHERITED FROM: axon trajectory variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant
F1F0 ATP synthase subunit C	0.01547	INHERITED FROM: nuclear appearance variant || recycling endosome localization variant || germ cell compartment morphology variant || endosome morphology variant || germ cell morphology variant || lysosome-related organelle morphology variant || germ cell compartment nuclei number variant || oocyte morphology variant || cell membrane organization biogenesis variant || germ cell compartment anucleate || vesicle morphology variant || germ cell compartment expansion variant || vesicle organization variant || oocytes lack nucleus || cell component localization variant || recycling endosome morphology variant || endosome localization variant || cell organization biogenesis variant || RAB-11 recycling endosome localization variant
CAD & PB1 domains	0.01547	INHERITED FROM: cell organization biogenesis variant
PLC-like phosphodiesterases	0.01595	INHERITED FROM: germ cell morphology variant || oocyte morphology variant || endomitotic oocytes
Calcium ATPase, transduction domain A	0.02204	INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant
PYP-like sensor domain (PAS domain)	0.02305	INHERITED FROM: neurite morphology variant
CCCH zinc finger	0.02396	INHERITED FROM: germ cell cytoplasmic morphology variant || P granule abnormal
SH2 domain	0.03399	INHERITED FROM: mitochondria alignment variant || mitochondria spacing variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant || cell component localization variant || muscle cell morphology variant || striated muscle morphology variant
Translational machinery components	0.036	INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || oocyte morphology variant || germ cell compartment expansion variant
Nucleotidylyl transferase	0.03962	INHERITED FROM: nuclei enlarged
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.04097	INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || germ cell compartment expansion variant
Myosin rod fragments	0.04097	INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || body wall muscle thick filament variant || striated muscle morphology variant
L30e-like	0.04097	INHERITED FROM: germ cell compartment morphology variant || nuclei small || oocyte number decreased || oocyte morphology variant || germ cell compartment expansion variant
EF-hand	0.04786	INHERITED FROM: annulae morphology variant || endomitotic oocytes
Cyclin-like	0.06389	INHERITED FROM: embryonic cell organization biogenesis variant || pronucleus centrosomes defective early emb || pronuclear size defective early emb || pronuclear morphology defective early emb || nuclear appearance number defective early emb || multiple cytoplasmic cavities early emb || embryonic cell morphology variant || excess pronucleus early emb || multiple nuclei early emb || cytoplasmic appearance variant || nuclear morphology variation early emb || nucleus defective early emb || excess maternal pronucleus early emb
ACP-like	0.06613	INHERITED FROM: oocyte number decreased || oocyte morphology variant
Second domain of FERM	0.07336	INHERITED FROM: mitochondria alignment variant || mitochondria spacing variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant || cell component localization variant || striated muscle morphology variant
Ribosomal protein S5 domain 2-like	0.08104	INHERITED FROM: nuclear appearance variant || germ cell compartment expansion variant
Glutathione synthetase ATP-binding domain-like	0.1041	INHERITED FROM: body wall muscle myosin organization defective || body wall muscle thick filament variant
SAM/Pointed domain	0.1946	INHERITED FROM: synapse morphology variant
Concanavalin A-like lectins/glucanases	0.2397	INHERITED FROM: neurite morphology variant || commissure handedness defective || axon morphology variant
SMAD/FHA domain	0.2574	INHERITED FROM: axon branching variant
Cystine-knot cytokines	0.4137	INHERITED FROM: synapse morphology variant
(Phosphotyrosine protein) phosphatases II	0.6944	INHERITED FROM: mitochondria alignment variant || mitochondria spacing variant
POZ domain	0.846	INHERITED FROM: embryonic cell organization biogenesis variant || cytoskeleton organization biogenesis variant || cytoplasmic appearance defective early emb || spindle position orientation defective early emb || cytoplasmic dynamics defective early emb || spindle defective early emb || spindle position variant || spindle position defective early emb || cytoplasmic appearance variant || spindle variant || excessive blebbing early emb || microtubule organization biogenesis variant || mitotic spindle defective early emb
Voltage-gated potassium channels	1	INHERITED FROM: mitochondria morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant || striated muscle morphology variant
L domain-like	1	INHERITED FROM: myopodia present
NAD(P)-binding Rossmann-fold domains	1	INHERITED FROM: fat associated bodies variant

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Family

Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
POU-specific domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Inositol polyphosphate 5-phosphatase (IPP5)	0	DIRECT
Heme-dependent catalases	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
14-3-3 protein	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
Mammalian PLC	0	DIRECT
LEM domain	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
Integrin domains	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Nucleosome core histones	0.000000000001841	DIRECT
Motor proteins	0.00000000223	DIRECT
Skp1 dimerisation domain-like	0.00000003109	DIRECT
WD40-repeat	0.0000002233	DIRECT
Calponin-homology domain, CH-domain	0.0000004764	DIRECT
Tubulin, C-terminal domain	0.000001367	DIRECT
I set domains	0.000001427	DIRECT
BCR-homology GTPase activation domain (BH-domain)	0.00000265	DIRECT
Proteasome subunits	0.000003087	DIRECT
Pleckstrin-homology domain (PH domain)	0.000004281	DIRECT
Tubulin, GTPase domain	0.000004692	DIRECT
t-snare proteins	0.000005655	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0.00001478	DIRECT
G proteins	0.00001877	DIRECT
Actin/HSP70	0.00002224	DIRECT
Pumilio repeat	0.00004266	DIRECT
LIM domain	0.00004266	DIRECT
Fibronectin type III	0.00005246	DIRECT
SH3-domain	0.0000605	DIRECT
Clathrin adaptor core protein	0.00009537	DIRECT
Clathrin coat assembly domain	0.00009537	DIRECT
PDZ domain	0.0001649	DIRECT
Tropomyosin	0.0001776	DIRECT
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain	0.0002204	DIRECT
DNA replication initiator (cdc21/cdc54) N-terminal domain	0.0003856	DIRECT
Laminin-type module	0.0003856	DIRECT
RecA protein-like (ATPase-domain)	0.0003856	DIRECT
Armadillo repeat	0.0005388	DIRECT
Spectrin repeat	0.0005939	DIRECT
BAR domain	0.001544	INHERITED FROM: cell component morphology variant
Ubiquitin activating enzymes (UBA)	0.001544	INHERITED FROM: cell component morphology variant
ValRS/IleRS/LeuRS editing domain	0.001544	INHERITED FROM: cell component morphology variant
Smc hinge domain	0.001544	INHERITED FROM: cell component morphology variant
EF-hand modules in multidomain proteins	0.001544	INHERITED FROM: cell type morphology variant || striated muscle morphology variant
Intermediate filament protein, coiled coil region	0.001651	INHERITED FROM: excretory cell morphology variant || excretory canal morphology variant || cell component morphology variant
PLC-like (P variant)	0.001651	INHERITED FROM: oocyte morphology variant || cell type morphology variant || body wall muscle sarcomere morphology variant || endomitotic oocytes || striated muscle morphology variant
Prefoldin	0.002014	INHERITED FROM: embryonic cell organization biogenesis variant || pronucleus centrosomes defective early emb || cytoskeleton organization biogenesis variant || spindle variant || microtubule organization biogenesis variant || cell organization biogenesis variant || mitotic spindle defective early emb || cell component morphology variant || pronuclear migration defective early emb
SNARE fusion complex	0.003934	INHERITED FROM: lysosome morphology variant
Canonical RBD	0.004229	INHERITED FROM: oocytes disorganized || P granule localization defective
Extended AAA-ATPase domain	0.004851	INHERITED FROM: embryonic cell organization biogenesis variant || cell cell contacts abnormal || cell cell contacts abnormal in four cell embryo || germ cell compartment anucleate || nucleus reforms cell division remnant early emb || multiple cytoplasmic cavities early emb || embryonic cell morphology variant || meiotic spindle defective early emb || germ cell compartment small || cytoplasmic appearance variant || endoplasmic reticulum morphology variant || excessive blebbing early emb || microtubule organization biogenesis variant || cell component morphology variant
Calpain large subunit, middle domain (domain III)	0.006077	INHERITED FROM: mitochondria morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant || striated muscle morphology variant
Cdc48 domain 2-like	0.006115	INHERITED FROM: germ cell cytoplasmic morphology variant || germ cell morphology variant || cytoplasmic processing body variant || endoplasmic reticulum morphology variant || cell organization biogenesis variant
Annexin	0.006115	INHERITED FROM: germ cell morphology variant
Anticodon-binding domain	0.006115	INHERITED FROM: germ cell compartment morphology variant || germ cell morphology variant || oocyte number decreased || oocyte morphology variant || germ cell compartment expansion variant || cell organization biogenesis variant
Ferredoxin reductase FAD-binding domain-like	0.006115	INHERITED FROM: endosome morphology variant || lysosome-related organelle morphology variant || vesicle morphology variant || vesicle organization variant || recycling endosome morphology variant
Troponin I	0.006115	INHERITED FROM: muscle cell morphology variant
Cdc48 N-terminal domain-like	0.006115	INHERITED FROM: germ cell cytoplasmic morphology variant || germ cell morphology variant || cytoplasmic processing body variant || endoplasmic reticulum morphology variant || cell organization biogenesis variant
First domain of FERM	0.006905	INHERITED FROM: mitochondria alignment variant || mitochondria spacing variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant || striated muscle morphology variant
Lamin A/C globular tail domain	0.0139	INHERITED FROM: excretory cell morphology variant || body wall muscle sarcomere morphology variant || excretory canal morphology variant
Growth factor receptor domain	0.02215	INHERITED FROM: myopodia present
Transforming growth factor (TGF)-beta	0.02291	INHERITED FROM: synapse morphology variant
L30e/L7ae ribosomal proteins	0.02291	INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || oocyte morphology variant || germ cell compartment expansion variant
DEP domain	0.02291	INHERITED FROM: embryonic cell organization biogenesis variant || cytoskeleton organization biogenesis variant || spindle defective early emb || organelle organization biogenesis variant || spindle variant || microtubule organization biogenesis variant || cell organization biogenesis variant || mitotic spindle defective early emb
F1F0 ATP synthase subunit C	0.02291	INHERITED FROM: nuclear appearance variant || recycling endosome localization variant || germ cell compartment morphology variant || endosome morphology variant || lysosome-related organelle morphology variant || germ cell compartment nuclei number variant || oocyte morphology variant || cell membrane organization biogenesis variant || germ cell compartment anucleate || vesicle morphology variant || germ cell compartment expansion variant || vesicle organization variant || oocytes lack nucleus || cell component localization variant || recycling endosome morphology variant || endosome localization variant || cell organization biogenesis variant || RAB-11 recycling endosome localization variant
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.02356	INHERITED FROM: oocyte number decreased || germ cell compartment expansion variant
DBL homology domain (DH-domain)	0.02403	INHERITED FROM: mitochondria alignment variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant || striated muscle morphology variant
Third domain of FERM	0.02674	INHERITED FROM: mitochondria alignment variant || mitochondria spacing variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant || cell component localization variant || striated muscle morphology variant
Synaptotagmin-like (S variant)	0.03425	INHERITED FROM: body wall muscle sarcomere morphology variant
Translational machinery components	0.03762	INHERITED FROM: nuclear appearance variant || germ cell compartment morphology variant || germ cell morphology variant || oocytes small || oocyte morphology variant || germ cell compartment expansion variant
Heat shock protein 70kD (HSP70), peptide-binding domain	0.03762	INHERITED FROM: germ cell morphology variant
Nitrogenase iron protein-like	0.04538	INHERITED FROM: oocyte number decreased
Laminin G-like module	0.04538	INHERITED FROM: neurite morphology variant || myopodia present || neuron morphology variant || commissure handedness defective || axon morphology variant
Calcium ATPase, transduction domain A	0.0497	INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant
Protein kinases, catalytic subunit	0.05692	INHERITED FROM: mitochondria alignment variant || myopodia present || mitochondrial content variant || muscle cell morphology variant
CCCH zinc finger	0.06087	INHERITED FROM: germ cell cytoplasmic morphology variant || P granule abnormal
Cyclin	0.06108	INHERITED FROM: nuclear appearance variant || embryonic cell organization biogenesis variant || pronucleus centrosomes defective early emb || pronuclear size defective early emb || pronuclear morphology defective early emb || nuclear appearance number defective early emb || multiple cytoplasmic cavities early emb || embryonic cell morphology variant || excess pronucleus early emb || multiple nuclei early emb || cytoplasmic appearance variant || nuclear morphology variation early emb || nucleus defective early emb || excess maternal pronucleus early emb
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	0.06108	INHERITED FROM: oocyte number decreased || nuclei enlarged
Myosin rod fragments	0.06528	INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || body wall muscle thick filament variant || striated muscle morphology variant
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.06528	INHERITED FROM: oocyte number decreased || germ cell compartment expansion variant
BTB/POZ domain	0.08866	INHERITED FROM: embryonic cell organization biogenesis variant || cytoskeleton organization biogenesis variant || cytoplasmic appearance defective early emb || spindle position orientation defective early emb || cytoplasmic dynamics defective early emb || spindle defective early emb || spindle position variant || spindle position defective early emb || organelle organization biogenesis variant || cytoplasmic appearance variant || spindle variant || excessive blebbing early emb || microtubule organization biogenesis variant || cell organization biogenesis variant || mitotic spindle defective early emb
DNA polymerase I	0.09477	INHERITED FROM: embryonic cell organization biogenesis variant
Second domain of FERM	0.09804	INHERITED FROM: mitochondria alignment variant || mitochondria spacing variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant || cell component localization variant || striated muscle morphology variant
Cold shock DNA-binding domain-like	0.1131	INHERITED FROM: nuclear appearance variant || germ cell cytoplasmic morphology variant || germ cell morphology variant || oocyte number decreased || germ cell compartment expansion variant || cytoplasmic processing body variant
SH2 domain	0.1268	INHERITED FROM: mitochondria alignment variant || mitochondria spacing variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant || cell component localization variant || muscle cell morphology variant || striated muscle morphology variant
Calpain large subunit, catalytic domain (domain II)	0.1383	INHERITED FROM: mitochondria morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant || striated muscle morphology variant
Elongation factors	0.167	INHERITED FROM: nuclear appearance variant || germ cell compartment morphology variant || oocytes small || oocyte morphology variant || germ cell compartment expansion variant
DnaQ-like 3'-5' exonuclease	0.2284	INHERITED FROM: embryonic cell organization biogenesis variant
FHA domain	0.2513	INHERITED FROM: neurite morphology variant || axon branching variant || axon morphology variant
Ubiquitin-related	0.3323	INHERITED FROM: nuclei small
Calmodulin-like	0.6609	INHERITED FROM: annulae morphology variant
Voltage-gated potassium channels	1	INHERITED FROM: mitochondria morphology variant

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Supra-domain (including individual superfamily)

Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
GroEL equatorial domain-like	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
14-3-3 protein	0	DIRECT
Integrin domains	0	DIRECT
LEM domain	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
GroEL apical domain-like	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
ARM repeat	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Histone-fold	0.0000000000004185	DIRECT
WD40 repeat-like	0.0000000000114	DIRECT
PH domain-like	0.000000003334	DIRECT
GTPase activation domain, GAP	0.000000007214	DIRECT
Skp1 dimerisation domain-like	0.000000009734	DIRECT
Calponin-homology domain, CH-domain	0.00000002602	DIRECT
Tubulin C-terminal domain-like	0.000000169	DIRECT
Sm-like ribonucleoproteins	0.0000006089	DIRECT
Tubulin nucleotide-binding domain-like	0.0000006875	DIRECT
SNARE-like	0.0000006891	DIRECT
t-snare proteins	0.00000142	DIRECT
SH3-domain	0.00000215	DIRECT
Fibronectin type III	0.000003096	DIRECT
TPR-like	0.000003766	DIRECT
C2 domain (Calcium/lipid-binding domain, CaLB)	0.0000136	DIRECT
Tropomyosin	0.00004866	DIRECT
Immunoglobulin	0.0001143	DIRECT
Class II aaRS and biotin synthetases	0.0001828	DIRECT
Troponin coil-coiled subunits	0.0002077	DIRECT
Prefoldin	0.0002077	DIRECT
Actin-like ATPase domain	0.0002116	DIRECT
Ubiquitin-like	0.0003075	DIRECT
RNA-binding domain, RBD	0.0003532	DIRECT
SNARE fusion complex	0.0003789	DIRECT
Lamin A/C globular tail domain	0.0005556	DIRECT
Intermediate filament protein, coiled coil region	0.0005556	DIRECT
Spectrin repeat	0.0005556	DIRECT
"Winged helix" DNA-binding domain	0.0006187	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.0006253	DIRECT
Trimeric LpxA-like enzymes	0.0006521	DIRECT
Nucleic acid-binding proteins	0.0006868	DIRECT
ValRS/IleRS/LeuRS editing domain	0.0007529	DIRECT
Ribosomal proteins S24e, L23 and L15e	0.0007529	DIRECT
Translation proteins SH3-like domain	0.001077	INHERITED FROM: cell membrane organization biogenesis variant || cell component morphology variant || germ cell morphology variant || germ cell compartment expansion variant || oocyte number decreased || cell type morphology variant
Cysteine-rich domain	0.001851	INHERITED FROM: striated muscle morphology variant || mitochondria alignment variant || axon morphology variant || body wall muscle sarcomere morphology variant || germ cell partition morphology variant || cell type morphology variant
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.002718	INHERITED FROM: cell component morphology variant || endosome morphology variant || recycling endosome morphology variant || lysosome-related organelle morphology variant || vesicle morphology variant || vesicle organization variant
Class II aaRS ABD-related	0.002718	INHERITED FROM: cytoplasmic processing body variant || cell component morphology variant || germ cell morphology variant || cell type morphology variant
Activating enzymes of the ubiquitin-like proteins	0.002718	INHERITED FROM: cell component morphology variant || germ cell compartment nuclei number variant || germ cell morphology variant
Calpain large subunit, middle domain (domain III)	0.002718	INHERITED FROM: cell component morphology variant || striated muscle morphology variant || muscle cell morphology variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant || cell type morphology variant
Riboflavin synthase domain-like	0.002718	INHERITED FROM: cell component morphology variant || endosome morphology variant || recycling endosome morphology variant || lysosome-related organelle morphology variant || vesicle morphology variant || vesicle organization variant
Actin depolymerizing proteins	0.003486	INHERITED FROM: cell type morphology variant
Cdc48 domain 2-like	0.003493	INHERITED FROM: cytoplasmic processing body variant || germ cell cytoplasmic morphology variant || endoplasmic reticulum morphology variant || germ cell morphology variant || cell organization biogenesis variant
Annexin	0.003493	INHERITED FROM: germ cell morphology variant
beta-sandwich domain of Sec23/24	0.003493	INHERITED FROM: oocyte morphology variant || germ cell morphology variant || germline nuclear positioning variant || germ cell compartment expansion variant || cell organization biogenesis variant || germ cell compartment size variant || nuclear positioning variant || germ cell compartment morphology variant || organelle organization biogenesis variant
ADC-like	0.003493	INHERITED FROM: cytoplasmic processing body variant || germ cell cytoplasmic morphology variant || endoplasmic reticulum morphology variant || germ cell morphology variant || cell organization biogenesis variant
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.003537	INHERITED FROM: oocyte morphology variant || germline nuclear positioning variant || germ cell compartment expansion variant || oocyte number decreased || germ cell compartment morphology variant || nuclei enlarged
Growth factor receptor domain	0.004915	INHERITED FROM: muscle cell morphology variant || body wall muscle sarcomere morphology variant
dsRNA-binding domain-like	0.007213	INHERITED FROM: cytoplasmic processing body variant || germ cell morphology variant
PDZ domain-like	0.008245	INHERITED FROM: synapse morphology variant || cell membrane morphology variant || actin organization biogenesis variant || cell junction variant || endomitotic oocytes
Metal cation-transporting ATPase, ATP-binding domain N	0.008319	INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant || cell type morphology variant
Zn-binding ribosomal proteins	0.008392	INHERITED FROM: cytoplasmic processing body variant || germ cell morphology variant
DBL homology domain (DH-domain)	0.008675	INHERITED FROM: striated muscle morphology variant || mitochondria alignment variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant
Protein kinase-like (PK-like)	0.009581	INHERITED FROM: myopodia present || mitochondrial content variant || mitochondria alignment variant || muscle cell morphology variant || mitochondria spacing variant
HAD-like	0.01055	INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant
Translation proteins	0.0111	INHERITED FROM: germ cell morphology variant || germ cell compartment expansion variant
S15/NS1 RNA-binding domain	0.01206	INHERITED FROM: oocyte morphology variant || germ cell morphology variant || germ cell compartment expansion variant || germ cell compartment morphology variant
Calcium ATPase, transmembrane domain M	0.0122	INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant
EGF/Laminin	0.01263	INHERITED FROM: muscle cell morphology variant || axon trajectory variant || body wall muscle sarcomere morphology variant
F1F0 ATP synthase subunit C	0.0134	INHERITED FROM: cell membrane organization biogenesis variant || recycling endosome localization variant || oocytes lack nucleus || RAB-11 recycling endosome localization variant || oocyte morphology variant || nuclear appearance variant || germ cell compartment nuclei number variant || endosome morphology variant || recycling endosome morphology variant || cell component localization variant || germ cell morphology variant || germ cell compartment expansion variant || lysosome-related organelle morphology variant || cell organization biogenesis variant || vesicle morphology variant || vesicle organization variant || endosome localization variant || germ cell compartment anucleate || germ cell compartment morphology variant
CAD & PB1 domains	0.0134	INHERITED FROM: cell organization biogenesis variant
PLC-like phosphodiesterases	0.01384	INHERITED FROM: oocyte morphology variant || germ cell morphology variant || endomitotic oocytes
Calcium ATPase, transduction domain A	0.01921	INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant
PYP-like sensor domain (PAS domain)	0.02012	INHERITED FROM: neurite morphology variant
CCCH zinc finger	0.02093	INHERITED FROM: germ cell cytoplasmic morphology variant || P granule abnormal
SH2 domain	0.0299	INHERITED FROM: striated muscle morphology variant || cell component localization variant || mitochondria alignment variant || muscle cell morphology variant || mitochondria spacing variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant
Translational machinery components	0.0317	INHERITED FROM: oocyte morphology variant || germ cell compartment expansion variant || oocyte number decreased || germ cell compartment morphology variant
Nucleotidylyl transferase	0.03493	INHERITED FROM: nuclei enlarged
L30e-like	0.03613	INHERITED FROM: oocyte morphology variant || germ cell morphology variant || germ cell compartment expansion variant || oocyte number decreased || nuclei small || germ cell compartment morphology variant
Heat shock protein 70kD (HSP70), peptide-binding domain	0.03613	INHERITED FROM: germ cell morphology variant
Myosin rod fragments	0.03613	INHERITED FROM: striated muscle morphology variant || muscle cell morphology variant || body wall muscle sarcomere morphology variant || body wall muscle thick filament variant
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.03613	INHERITED FROM: germ cell compartment expansion variant || oocyte number decreased || germ cell compartment morphology variant
EF-hand	0.04237	INHERITED FROM: annulae morphology variant || endomitotic oocytes
Cyclin-like	0.05695	INHERITED FROM: cytoplasmic appearance variant || nuclear appearance number defective early emb || pronucleus centrosomes defective early emb || excess maternal pronucleus early emb || multiple nuclei early emb || embryonic cell organization biogenesis variant || excess pronucleus early emb || multiple cytoplasmic cavities early emb || pronuclear size defective early emb || nucleus defective early emb || pronuclear morphology defective early emb || embryonic cell morphology variant || nuclear morphology variation early emb
ACP-like	0.05902	INHERITED FROM: oocyte morphology variant || oocyte number decreased
Second domain of FERM	0.06564	INHERITED FROM: striated muscle morphology variant || cell component localization variant || mitochondria alignment variant || mitochondria spacing variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant
Ribosomal protein S5 domain 2-like	0.07274	INHERITED FROM: nuclear appearance variant || germ cell compartment expansion variant
Glutathione synthetase ATP-binding domain-like	0.09413	INHERITED FROM: body wall muscle myosin organization defective || body wall muscle thick filament variant
SAM/Pointed domain	0.1791	INHERITED FROM: synapse morphology variant
Concanavalin A-like lectins/glucanases	0.2222	INHERITED FROM: neurite morphology variant || commissure handedness defective || axon morphology variant
SMAD/FHA domain	0.2394	INHERITED FROM: axon branching variant
Cystine-knot cytokines	0.393	INHERITED FROM: synapse morphology variant
(Phosphotyrosine protein) phosphatases II	0.6736	INHERITED FROM: mitochondria alignment variant || mitochondria spacing variant
POZ domain	0.8289	INHERITED FROM: cytoplasmic appearance defective early emb || spindle defective early emb || spindle position defective early emb || cytoplasmic appearance variant || cytoskeleton organization biogenesis variant || excessive blebbing early emb || spindle position variant || spindle position orientation defective early emb || spindle variant || embryonic cell organization biogenesis variant || microtubule organization biogenesis variant || cytoplasmic dynamics defective early emb || mitotic spindle defective early emb
L domain-like	1	INHERITED FROM: myopodia present
Voltage-gated potassium channels	1	INHERITED FROM: striated muscle morphology variant || muscle cell morphology variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant
NAD(P)-binding Rossmann-fold domains	1	INHERITED FROM: fat associated bodies variant

Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
47473,51695 47473 - EF-hand 51695 - PLC-like phosphodiesterases	0	DIRECT
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like	0	DIRECT
81383,50978 81383 - F-box domain 50978 - WD40 repeat-like	0	DIRECT
81811,82754 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin	0	DIRECT
50729,47473 50729 - PH domain-like 47473 - EF-hand	0	DIRECT
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	DIRECT
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat	0	DIRECT
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
56112,48371 56112 - Protein kinase-like (PK-like) 48371 - ARM repeat	0	DIRECT
51695,49562 51695 - PLC-like phosphodiesterases 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like	0	DIRECT
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like	0	DIRECT
64356,49447 64356 - SNARE-like 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
49348,55711 49348 - Clathrin adaptor appendage domain 55711 - Subdomain of clathrin and coatomer appendage domain	0	DIRECT
54695,81382 54695 - POZ domain 81382 - Skp1 dimerisation domain-like	0.000000009759	DIRECT
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.0000001558	DIRECT
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like	0.0000006875	DIRECT
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.000004429	DIRECT
48371,48371 48371 - ARM repeat 48371 - ARM repeat	0.000008766	DIRECT
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	0.0000171	DIRECT
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat	0.00003333	DIRECT
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III	0.000185	DIRECT
48452,48452 48452 - TPR-like 48452 - TPR-like	0.0002916	DIRECT
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.0003367	DIRECT
50677,52374 50677 - ValRS/IleRS/LeuRS editing domain 52374 - Nucleotidylyl transferase	0.0007529	DIRECT
64593,74853 64593 - Intermediate filament protein, coiled coil region 74853 - Lamin A/C globular tail domain	0.0008659	DIRECT
54001,49758 54001 - Cysteine proteinases 49758 - Calpain large subunit, middle domain (domain III)	0.0008659	DIRECT
50044,55550 50044 - SH3-domain 55550 - SH2 domain	0.0008659	DIRECT
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III	0.002718	INHERITED FROM: cell component morphology variant || striated muscle morphology variant || axon morphology variant || body wall muscle sarcomere morphology variant
50978,50978 50978 - WD40 repeat-like 50978 - WD40 repeat-like	0.002736	INHERITED FROM: cell component morphology variant || cilia morphology variant || ciliated neuron morphology variant
63380,52343 63380 - Riboflavin synthase domain-like 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain	0.003486	INHERITED FROM: endosome morphology variant || recycling endosome morphology variant || lysosome-related organelle morphology variant || vesicle morphology variant || vesicle organization variant
81333,81333 81333 - F1F0 ATP synthase subunit C 81333 - F1F0 ATP synthase subunit C	0.003493	INHERITED FROM: cell membrane organization biogenesis variant || recycling endosome localization variant || oocytes lack nucleus || RAB-11 recycling endosome localization variant || oocyte morphology variant || nuclear appearance variant || germ cell compartment nuclei number variant || endosome morphology variant || recycling endosome morphology variant || cell component localization variant || germ cell morphology variant || germ cell compartment expansion variant || lysosome-related organelle morphology variant || cell organization biogenesis variant || vesicle morphology variant || vesicle organization variant || endosome localization variant || germ cell compartment anucleate || germ cell compartment morphology variant
55681,52954 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related	0.003493	INHERITED FROM: germ cell morphology variant
55550,50044 55550 - SH2 domain 50044 - SH3-domain	0.003493	INHERITED FROM: striated muscle morphology variant || cell component localization variant || mitochondria alignment variant || muscle cell morphology variant || mitochondria spacing variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like	0.005058	INHERITED FROM: cytoplasmic appearance variant || nuclear appearance number defective early emb || nuclear appearance variant || pronucleus centrosomes defective early emb || excess maternal pronucleus early emb || multiple nuclei early emb || embryonic cell organization biogenesis variant || excess pronucleus early emb || multiple cytoplasmic cavities early emb || pronuclear size defective early emb || nuclear number defective early emb || nucleus defective early emb || pronuclear morphology defective early emb || embryonic cell morphology variant || nuclear morphology variation early emb
81660,56784 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like	0.008319	INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant || cell type morphology variant
50044,50044 50044 - SH3-domain 50044 - SH3-domain	0.00955	INHERITED FROM: striated muscle morphology variant || mitochondria alignment variant || mitochondria spacing variant || body wall muscle sarcomere morphology variant
50249,55681 50249 - Nucleic acid-binding proteins 55681 - Class II aaRS and biotin synthetases	0.0134	INHERITED FROM: oocyte morphology variant || germ cell morphology variant || germ cell compartment expansion variant || cell organization biogenesis variant || oocyte number decreased || germ cell compartment morphology variant
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.01384	INHERITED FROM: striated muscle morphology variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like	0.01384	INHERITED FROM: striated muscle morphology variant || cell component localization variant || mitochondria alignment variant || mitochondria spacing variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0.02012	INHERITED FROM: germ cell morphology variant
53098,56672 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases	0.0317	INHERITED FROM: embryonic cell organization biogenesis variant || cell organization biogenesis variant
57625,57625 57625 - Invertebrate chitin-binding proteins 57625 - Invertebrate chitin-binding proteins	0.0317	INHERITED FROM: cell organization biogenesis variant
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.03613	INHERITED FROM: germ cell compartment expansion variant || oocyte number decreased || germ cell compartment morphology variant
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.03613	INHERITED FROM: germ cell morphology variant
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM	0.05339	INHERITED FROM: striated muscle morphology variant || cell component localization variant || mitochondria alignment variant || mitochondria spacing variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant
52374,47323 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.05364	INHERITED FROM: oocyte morphology variant || nuclear appearance variant || germ cell compartment expansion variant || oocyte number decreased || germ cell compartment morphology variant || nuclei enlarged
90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments	0.05902	INHERITED FROM: striated muscle morphology variant || muscle cell morphology variant || body wall muscle sarcomere morphology variant || body wall muscle thick filament variant
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins	0.06564	INHERITED FROM: oocyte morphology variant || nuclear appearance variant || oocytes small || germ cell compartment expansion variant || germ cell compartment morphology variant
90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger	0.1665	INHERITED FROM: germ cell cytoplasmic morphology variant || P granule abnormal
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD	0.1704	INHERITED FROM: oocytes disorganized
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.3017	INHERITED FROM: endoplasmic reticulum morphology variant || meiotic spindle defective early emb
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.5226	INHERITED FROM: mitochondria alignment variant || mitochondria spacing variant

Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0	DIRECT
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat	0	DIRECT
50729,47473,51695 50729 - PH domain-like 47473 - EF-hand 51695 - PLC-like phosphodiesterases	0	DIRECT
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	DIRECT
48726,49265,48726 48726 - Immunoglobulin 49265 - Fibronectin type III 48726 - Immunoglobulin	0	DIRECT
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin	0.0000007321	DIRECT
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.00000142	DIRECT
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III	0.0001918	DIRECT
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.008666	INHERITED FROM: myopodia present
57625,57625,57625 57625 - Invertebrate chitin-binding proteins 57625 - Invertebrate chitin-binding proteins 57625 - Invertebrate chitin-binding proteins	0.0134	INHERITED FROM: cell organization biogenesis variant
81660,56784,81665 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like 81665 - Calcium ATPase, transmembrane domain M	0.01921	INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0.02012	INHERITED FROM: germ cell morphology variant
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like	0.03578	INHERITED FROM: striated muscle morphology variant || cell component localization variant || mitochondria alignment variant || mitochondria spacing variant || mitochondria morphology variant || body wall muscle sarcomere morphology variant
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.03613	INHERITED FROM: germ cell morphology variant
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.03613	INHERITED FROM: germ cell compartment expansion variant || oocyte number decreased || germ cell compartment morphology variant