Worm Phenotype (WP): organ system morphology variant

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Helical domain of Sec23/24	0	Direct
P-loop containing nucleoside triphosphate hydrolases	0	Direct
Ribosomal proteins S24e, L23 and L15e	0	Direct
GroEL-intermediate domain like	0	Direct
GroEL equatorial domain-like	0	Direct
Plexin repeat	0	Direct
C-terminal, gelsolin-like domain of Sec23/24	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
14-3-3 protein	0	Direct
Multidrug efflux transporter AcrB transmembrane domain	0	Direct
Zn-finger domain of Sec23/24	0	Direct
S-adenosylmethionine synthetase	0	Direct
Nop domain	0	Direct
Subdomain of clathrin and coatomer appendage domain	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Integrin domains	0	Direct
WD40 repeat-like	0.0000000006122	Direct
ARM repeat	0.000000001658	Direct
PH domain-like	0.000000001954	Direct
Transducin (alpha subunit), insertion domain	0.000000002113	Direct
GTPase activation domain, GAP	0.000000006137	Direct
TPR-like	0.0000000794	Direct
Tubulin C-terminal domain-like	0.0000001605	Direct
"Winged helix" DNA-binding domain	0.0000001755	Direct
Homeodomain-like	0.0000002593	Direct
GroEL apical domain-like	0.0000002942	Direct
Tubulin nucleotide-binding domain-like	0.0000006634	Direct
Nucleic acid-binding proteins	0.000001708	Direct
PYP-like sensor domain (PAS domain)	0.000007228	Direct
Translation proteins SH3-like domain	0.000009181	Direct
SH3-domain	0.00002196	Direct
HLH, helix-loop-helix DNA-binding domain	0.00005082	Direct
SNARE-like	0.0001167	Direct
Sema domain	0.0001724	Direct
Sec1/munc18-like (SM) proteins	0.0001724	Direct
SMAD MH1 domain	0.0001724	Direct
Hedgehog/intein (Hint) domain	0.000201	Direct
Prefoldin	0.000221	Direct
Activating enzymes of the ubiquitin-like proteins	0.000221	Direct
Calponin-homology domain, CH-domain	0.000229	Direct
Growth factor receptor domain	0.0003116	Direct
Tropomyosin	0.0005794	Direct
Fibronectin type III	0.0005922	Direct
Arginase/deacetylase	0.0007766	Direct
Glutathione synthetase ATP-binding domain-like	0.000799	Direct
Frizzled cysteine-rich domain	0.0008204	Direct
Subtilisin-like	0.0008204	Direct
Class II aaRS and biotin synthetases	0.0009888	Direct
beta-beta-alpha zinc fingers	0.001176	Inherited
Immunoglobulin	0.001645	Inherited
Retrovirus zinc finger-like domains	0.001802	Inherited
Bromodomain	0.001802	Inherited
DBL homology domain (DH-domain)	0.002044	Inherited
HMG-box	0.002044	Inherited
Protein kinase-like (PK-like)	0.002169	Inherited
Actin-like ATPase domain	0.002293	Inherited
Histone-fold	0.00277	Inherited
Calpain large subunit, middle domain (domain III)	0.002886	Inherited
Troponin coil-coiled subunits	0.002886	Inherited
GINS helical bundle-like	0.003417	Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)	0.003753	Inherited
Smc hinge domain	0.003756	Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase	0.003756	Inherited
RBP11-like subunits of RNA polymerase	0.003822	Inherited
Intermediate filament protein, coiled coil region	0.004406	Inherited
Spectrin repeat	0.004406	Inherited
Lamin A/C globular tail domain	0.004406	Inherited
SMAD/FHA domain	0.00524	Inherited
BAR/IMD domain-like	0.005488	Inherited
Cysteine-rich domain	0.005582	Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain	0.006767	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.007756	Inherited
RNA-binding domain, RBD	0.008526	Inherited
Sm-like ribonucleoproteins	0.00882	Inherited
Zn-binding ribosomal proteins	0.008943	Inherited
Cullin homology domain	0.01015	Inherited
EGF/Laminin	0.01149	Inherited
S15/NS1 RNA-binding domain	0.01299	Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.01332	Inherited
Class II aaRS ABD-related	0.02122	Inherited
p53-like transcription factors	0.02242	Inherited
SH2 domain	0.02788	Inherited
PDZ domain-like	0.03161	Inherited
TAZ domain	0.03365	Inherited
Translational machinery components	0.03365	Inherited
Myosin rod fragments	0.03783	Inherited
L30e-like	0.03783	Inherited
Translation proteins	0.07991	Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.08005	Inherited
SAM/Pointed domain	0.08505	Inherited
PX domain	0.1228	Inherited
Concanavalin A-like lectins/glucanases	0.1388	Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.1435	Inherited
Second domain of FERM	0.1692	Inherited
Cystine-knot cytokines	0.3971	Inherited
Nucleotide-diphospho-sugar transferases	0.6709	Inherited
Voltage-gated potassium channels	0.8841	Inherited
C-type lectin-like	1	Inherited
NAD(P)-binding Rossmann-fold domains	1	Inherited

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Family

(show details)

SCOP term	FDR (all)	Annotation (direct or inherited)
POU-specific domain	0	Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain	0	Direct
Nop domain	0	Direct
beta-sandwich domain of Sec23/24	0	Direct
Inositol polyphosphate 5-phosphatase (IPP5)	0	Direct
Quinoprotein alcohol dehydrogenase-like	0	Direct
Helical domain of Sec23/24	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Sema domain	0	Direct
Zn-finger domain of Sec23/24	0	Direct
Proprotein convertase P-domain	0	Direct
Group II chaperonin (CCT, TRIC), intermediate domain	0	Direct
RNA-polymerase beta	0	Direct
14-3-3 protein	0	Direct
Trunk domain of Sec23/24	0	Direct
Group II chaperonin (CCT, TRIC), ATPase domain	0	Direct
MIF4G domain-like	0	Direct
Integrin domains	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
S-adenosylmethionine synthetase	0	Direct
Plexin repeat	0	Direct
C-terminal, gelsolin-like domain of Sec23/24	0	Direct
Multidrug efflux transporter AcrB transmembrane domain	0.000000000000005004	Direct
G proteins	0.0000000001751	Direct
Transducin (alpha subunit), insertion domain	0.00000002758	Direct
Homeodomain	0.000000097	Direct
WD40-repeat	0.0000003761	Direct
Tubulin, C-terminal domain	0.000001103	Direct
BCR-homology GTPase activation domain (BH-domain)	0.000002096	Direct
Proteasome subunits	0.000002562	Direct
Pleckstrin-homology domain (PH domain)	0.000003191	Direct
Tubulin, GTPase domain	0.000003848	Direct
Group II chaperonin (CCT, TRIC), apical domain	0.000004884	Direct
Motor proteins	0.0000111	Direct
I set domains	0.00001112	Direct
Actin/HSP70	0.00001777	Direct
Laminin-type module	0.0003501	Direct
Sec1/munc18-like (SM) proteins	0.0003501	Direct
SMAD MH1 domain	0.0003501	Direct
Classic zinc finger, C2H2	0.000364	Direct
SH3-domain	0.0003663	Direct
HLH, helix-loop-helix DNA-binding domain	0.0004405	Direct
SMAD domain	0.0005112	Direct
Reprolysin-like	0.0005112	Direct
Histone deacetylase, HDAC	0.0005112	Direct
Translational machinery components	0.0005112	Direct
LIM domain	0.0005272	Direct
Hedgehog C-terminal (Hog) autoprocessing domain	0.0005272	Direct
Growth factor receptor domain	0.0009042	Direct
Tetratricopeptide repeat (TPR)	0.0009857	Direct
Calponin-homology domain, CH-domain	0.001242	Inherited
Cold shock DNA-binding domain-like	0.001242	Inherited
Ubiquitin activating enzymes (UBA)	0.001427	Inherited
Smc hinge domain	0.001427	Inherited
Subtilases	0.001427	Inherited
Frizzled cysteine-rich domain	0.001427	Inherited
Tropomyosin	0.001472	Inherited
PDZ domain	0.001795	Inherited
Prefoldin	0.001837	Inherited
Clathrin adaptor core protein	0.001837	Inherited
Clathrin coat assembly domain	0.001837	Inherited
Fibronectin type III	0.003879	Inherited
Spectrin repeat	0.004442	Inherited
Retrovirus zinc finger-like domains	0.004847	Inherited
Bromodomain	0.004847	Inherited
Cyclin	0.004909	Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain	0.004909	Inherited
Calpain large subunit, middle domain (domain III)	0.00558	Inherited
Anticodon-binding domain	0.005747	Inherited
Glycosyl transferases group 1	0.005747	Inherited
Troponin I	0.005747	Inherited
Anticodon-binding domain of Class II aaRS	0.005747	Inherited
DBL homology domain (DH-domain)	0.005988	Inherited
HMG-box	0.005988	Inherited
RecA protein-like (ATPase-domain)	0.006408	Inherited
Intermediate filament protein, coiled coil region	0.009358	Inherited
PLC-like (P variant)	0.009358	Inherited
Lamin A/C globular tail domain	0.01281	Inherited
Protein kinases, catalytic subunit	0.01703	Inherited
Armadillo repeat	0.01731	Inherited
Nucleosome core histones	0.01776	Inherited
Canonical RBD	0.02036	Inherited
Transforming growth factor (TGF)-beta	0.0216	Inherited
L30e/L7ae ribosomal proteins	0.0216	Inherited
DEP domain	0.0216	Inherited
EF-hand modules in multidomain proteins	0.0216	Inherited
Forkhead DNA-binding domain	0.02692	Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP	0.02908	Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain	0.03521	Inherited
Tandem AAA-ATPase domain	0.04044	Inherited
Laminin G-like module	0.04215	Inherited
First domain of FERM	0.04985	Inherited
Myosin rod fragments	0.0614	Inherited
Third domain of FERM	0.09558	Inherited
SH2 domain	0.1116	Inherited
Calpain large subunit, catalytic domain (domain II)	0.1302	Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.2012	Inherited
Second domain of FERM	0.2165	Inherited
Synaptotagmin-like (S variant)	0.2165	Inherited
Chromo domain	0.2398	Inherited
FHA domain	0.2398	Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.2502	Inherited
Elongation factors	0.3161	Inherited
C-type lectin domain	1	Inherited

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
GroEL equatorial domain-like	0	Direct
P-loop containing nucleoside triphosphate hydrolases	0	Direct
C-terminal, gelsolin-like domain of Sec23/24	0	Direct
14-3-3 protein	0	Direct
S-adenosylmethionine synthetase	0	Direct
Ribosomal proteins S24e, L23 and L15e	0	Direct
Integrin domains	0	Direct
Plexin repeat	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
GroEL-intermediate domain like	0	Direct
Subdomain of clathrin and coatomer appendage domain	0	Direct
Helical domain of Sec23/24	0	Direct
Nop domain	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Multidrug efflux transporter AcrB transmembrane domain	0	Direct
Zn-finger domain of Sec23/24	0	Direct
WD40 repeat-like	0.0000000004858	Direct
ARM repeat	0.000000001318	Direct
PH domain-like	0.000000001553	Direct
Transducin (alpha subunit), insertion domain	0.00000000168	Direct
GTPase activation domain, GAP	0.00000000489	Direct
TPR-like	0.00000006359	Direct
Tubulin C-terminal domain-like	0.0000001288	Direct
"Winged helix" DNA-binding domain	0.0000001409	Direct
Homeodomain-like	0.0000002085	Direct
GroEL apical domain-like	0.0000002366	Direct
Tubulin nucleotide-binding domain-like	0.0000005353	Direct
Nucleic acid-binding proteins	0.000001383	Direct
PYP-like sensor domain (PAS domain)	0.00000588	Direct
Translation proteins SH3-like domain	0.00000747	Direct
SH3-domain	0.0000179	Direct
HLH, helix-loop-helix DNA-binding domain	0.00004158	Direct
SNARE-like	0.00009571	Direct
Sema domain	0.0001415	Direct
SMAD MH1 domain	0.0001415	Direct
Sec1/munc18-like (SM) proteins	0.0001415	Direct
Hedgehog/intein (Hint) domain	0.000165	Direct
Prefoldin	0.0001816	Direct
Activating enzymes of the ubiquitin-like proteins	0.0001816	Direct
Calponin-homology domain, CH-domain	0.0001883	Direct
Growth factor receptor domain	0.0002567	Direct
Tropomyosin	0.0004799	Direct
Fibronectin type III	0.0004906	Direct
Arginase/deacetylase	0.0006456	Direct
Glutathione synthetase ATP-binding domain-like	0.0006645	Direct
Subtilisin-like	0.0006823	Direct
Frizzled cysteine-rich domain	0.0006823	Direct
Class II aaRS and biotin synthetases	0.000823	Direct
beta-beta-alpha zinc fingers	0.0009805	Direct
Immunoglobulin	0.001375	Inherited
Bromodomain	0.001508	Inherited
Retrovirus zinc finger-like domains	0.001508	Inherited
HMG-box	0.001714	Inherited
DBL homology domain (DH-domain)	0.001714	Inherited
Protein kinase-like (PK-like)	0.001822	Inherited
Actin-like ATPase domain	0.001927	Inherited
Histone-fold	0.002336	Inherited
Troponin coil-coiled subunits	0.002435	Inherited
Calpain large subunit, middle domain (domain III)	0.002435	Inherited
GINS helical bundle-like	0.002891	Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)	0.003179	Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase	0.003181	Inherited
Smc hinge domain	0.003181	Inherited
RBP11-like subunits of RNA polymerase	0.003238	Inherited
Lamin A/C globular tail domain	0.003736	Inherited
Intermediate filament protein, coiled coil region	0.003736	Inherited
Spectrin repeat	0.003736	Inherited
SMAD/FHA domain	0.004454	Inherited
BAR/IMD domain-like	0.004667	Inherited
Cysteine-rich domain	0.004749	Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain	0.005772	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.006631	Inherited
RNA-binding domain, RBD	0.00731	Inherited
Sm-like ribonucleoproteins	0.007566	Inherited
Zn-binding ribosomal proteins	0.007675	Inherited
Cullin homology domain	0.008733	Inherited
EGF/Laminin	0.009903	Inherited
S15/NS1 RNA-binding domain	0.01122	Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.01151	Inherited
Bet v1-like	0.01241	Inherited
Class II aaRS ABD-related	0.01849	Inherited
p53-like transcription factors	0.01956	Inherited
SH2 domain	0.02444	Inherited
PDZ domain-like	0.02778	Inherited
Translational machinery components	0.0296	Inherited
TAZ domain	0.0296	Inherited
L30e-like	0.03335	Inherited
Myosin rod fragments	0.03335	Inherited
Chromo domain-like	0.05105	Inherited
Translation proteins	0.07169	Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.07183	Inherited
SAM/Pointed domain	0.07643	Inherited
PX domain	0.1114	Inherited
Concanavalin A-like lectins/glucanases	0.1264	Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.1308	Inherited
Second domain of FERM	0.155	Inherited
Cystine-knot cytokines	0.3766	Inherited
Nucleotide-diphospho-sugar transferases	0.6494	Inherited
Voltage-gated potassium channels	0.8685	Inherited
NAD(P)-binding Rossmann-fold domains	1	Inherited
C-type lectin-like	1	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like	0	Direct
54897,52743 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like	0	Direct
81383,50978 81383 - F-box domain 50978 - WD40 repeat-like	0	Direct
81811,82754 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24	0	Direct
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin	0	Direct
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	Direct
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
101912,103575 101912 - Sema domain 103575 - Plexin repeat	0	Direct
55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase	0	Direct
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
52743,49785 52743 - Subtilisin-like 49785 - Galactose-binding domain-like	0	Direct
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like	0	Direct
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like	0	Direct
49348,55711 49348 - Clathrin adaptor appendage domain 55711 - Subdomain of clathrin and coatomer appendage domain	0	Direct
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0.00000000168	Direct
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like	0.0000005353	Direct
48452,48452 48452 - TPR-like 48452 - TPR-like	0.000006215	Direct
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.00001343	Direct
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.00006399	Direct
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers	0.00007779	Direct
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III	0.0001527	Direct
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	0.0002661	Direct
50978,50978 50978 - WD40 repeat-like 50978 - WD40 repeat-like	0.0003374	Direct
48371,48371 48371 - ARM repeat 48371 - ARM repeat	0.0004891	Direct
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like	0.0007555	Direct
64593,74853 64593 - Intermediate filament protein, coiled coil region 74853 - Lamin A/C globular tail domain	0.0007719	Direct
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat	0.0007719	Direct
54001,49758 54001 - Cysteine proteinases 49758 - Calpain large subunit, middle domain (domain III)	0.0007719	Direct
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.001073	Inherited
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.002386	Inherited
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0.002435	Inherited
81333,81333 81333 - F1F0 ATP synthase subunit C 81333 - F1F0 ATP synthase subunit C	0.003238	Inherited
55550,50044 55550 - SH2 domain 50044 - SH3-domain	0.003238	Inherited
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.005772	Inherited
50044,50044 50044 - SH3-domain 50044 - SH3-domain	0.008733	Inherited
54160,54160 54160 - Chromo domain-like 54160 - Chromo domain-like	0.008733	Inherited
50044,55550 50044 - SH3-domain 55550 - SH2 domain	0.008733	Inherited
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like	0.01151	Inherited
50249,55681 50249 - Nucleic acid-binding proteins 55681 - Class II aaRS and biotin synthetases	0.01248	Inherited
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III	0.01849	Inherited
48403,48403 48403 - Ankyrin repeat 48403 - Ankyrin repeat	0.03335	Inherited
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like	0.04896	Inherited
52374,47323 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.05027	Inherited
90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments	0.05529	Inherited
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.1308	Inherited
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM	0.1477	Inherited
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins	0.155	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48371,48371,48371 48371 - ARM repeat 48371 - ARM repeat 48371 - ARM repeat	0	Direct
55973,55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase	0	Direct
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	Direct
48726,49265,48726 48726 - Immunoglobulin 49265 - Fibronectin type III 48726 - Immunoglobulin	0	Direct
54897,52743,49785 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like 49785 - Galactose-binding domain-like	0	Direct
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin	0.0000268	Direct
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.00004171	Direct
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat	0.0001415	Direct
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III	0.000165	Direct
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0.002435	Inherited
52540,52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.003238	Inherited
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.005772	Inherited
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers	0.02597	Inherited
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like	0.1114	Inherited
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.1308	Inherited

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Worm Phenotype (WP): organ system morphology variant

Superfamily

Family

Supra-domain (including individual superfamily)