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Worm Phenotype (WP): organism physiology variant
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Doublecortin (DC) | 0 | DIRECT |
| GAT-like domain | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| NagB/RpiA/CoA transferase-like | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Retrovirus zinc finger-like domains | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| ARID-like | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Molybdenum cofactor biosynthesis proteins | 0 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| Tubby C-terminal domain-like | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| HCP-like | 0 | DIRECT |
| DEATH domain | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
| alpha/beta knot | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| PK beta-barrel domain-like | 0 | DIRECT |
| eIF4e-like | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | DIRECT |
| WWE domain | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| Pepsin inhibitor-3 | 0 | DIRECT |
| Pentein | 0 | DIRECT |
| Elafin-like | 0 | DIRECT |
| Invertebrate chitin-binding proteins | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| ArfGap/RecO-like zinc finger | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| Carbon-nitrogen hydrolase | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| t-snare proteins | 0 | DIRECT |
| Outer arm dynein light chain 1 | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| Ribosomal L27 protein-like | 0 | DIRECT |
| PIN domain-like | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| GroEL equatorial domain-like | 0 | DIRECT |
| Nucleotidyltransferase | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Cullin repeat-like | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
| Fibrinogen C-terminal domain-like | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Band 7/SPFH domain | 0 | DIRECT |
| Ferritin-like | 0 | DIRECT |
| Diaminopimelate epimerase-like | 0 | DIRECT |
| FAD-binding/transporter-associated domain-like | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| Carbohydrate phosphatase | 0 | DIRECT |
| Chromo domain-like | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| Citrate synthase | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| MgtE membrane domain-like | 0 | DIRECT |
| ENTH/VHS domain | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| ADP-ribosylation | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| Hedgehog/intein (Hint) domain | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
| lambda repressor-like DNA-binding domains | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| Acetyl-CoA synthetase-like | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Ran binding protein zinc finger-like | 0 | DIRECT |
| Periplasmic binding protein-like II | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| CBD9-like | 0 | DIRECT |
| Kringle-like | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
| PUA domain-like | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| CAD & PB1 domains | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| Phoshotransferase/anion transport protein | 0 | DIRECT |
| ACP-like | 0 | DIRECT |
| HSP20-like chaperones | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| Radical SAM enzymes | 0 | DIRECT |
| VPS9 domain | 0 | DIRECT |
| Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| Oxysterol-binding protein-like | 0 | DIRECT |
| Cystatin/monellin | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| dsRNA-binding domain-like | 0 | DIRECT |
| Intermediate filament protein, coiled coil region | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| Histone-fold | 0 | DIRECT |
| Profilin (actin-binding protein) | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| Terpenoid synthases | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Galactose mutarotase-like | 0 | DIRECT |
| Cadherin-like | 0 | DIRECT |
| PEBP-like | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| Skp1 dimerisation domain-like | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| Clc chloride channel | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| Spectrin repeat | 0 | DIRECT |
| Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| Sec63 N-terminal domain-like | 0 | DIRECT |
| Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| ISP domain | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| MFPT repeat-like | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| ThrRS/AlaRS common domain | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| PreATP-grasp domain | 0 | DIRECT |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| Ribokinase-like | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Protease propeptides/inhibitors | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| PYP-like sensor domain (PAS domain) | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| Chitinase insertion domain | 0 | DIRECT |
| Glycolipid transfer protein, GLTP | 0 | DIRECT |
| Ribosomal protein S18 | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Galactose oxidase, central domain | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| SAND domain-like | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| GroEL apical domain-like | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
| TGS-like | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| Hypothetical protein c14orf129, hspc210 | 0 | DIRECT |
| GAS2 domain-like | 0 | DIRECT |
| cAMP-binding domain-like | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0 | DIRECT |
| HRDC-like | 0 | DIRECT |
| Carboxypeptidase regulatory domain-like | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| L30e-like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Actin-like ATPase domain | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| SCP-like | 0 | DIRECT |
| Thiolase-like | 0 | DIRECT |
| PHM/PNGase F | 0 | DIRECT |
| YbiA-like | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| PAP/OAS1 substrate-binding domain | 0 | DIRECT |
| R3H domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0.0000004141 | DIRECT |
| PH domain-like | 0.00002159 | DIRECT |
| PapD-like | 0.009043 | INHERITED FROM: larval arrest || dauer metabolism variant || lipid metabolism variant || slow growth || larval growth variant || fat content variant || developmental growth variant || dauer lifespan extended || dauer lifespan variant |
| PDZ domain-like | 0.009221 | INHERITED FROM: protein expression variant || acetylcholinesterase inhibitor response variant || drug resistant || chemical resistant || aldicarb response variant |
| TPR-like | 0.01305 | INHERITED FROM: antihelmintic response variant || positive chemotaxis defective || light body touch resistant || chemotaxis variant || ivermectin resistant || ivermectin response variant || dauer development variant |
| Periplasmic binding protein-like I | 0.01452 | INHERITED FROM: bromide chemotaxis variant || organism environmental stimulus response variant || magnesium chemotaxis defective || thermosensory behavior variant || lithium chemotaxis defective || diacetyl chemotaxis variant || thermotaxis variant || chemotaxis variant || carbon dioxide response variant || iodide chemotaxis variant || benzaldehyde chemotaxis variant || chemosensory response variant || iodide chemotaxis defective || bromide chemotaxis defective || aqueous chemosensory response variant || second messenger mediated signaling variant || memory retention defective || alkaline pH chemotaxis variant || mechanosensation variant || organism temperature response variant || AWC odorant chemotaxis defective || AWC odorant chemotaxis variant || aqueous positive chemotaxis variant || carbon dioxide avoidance variant |
| ABC transporter transmembrane region | 0.02042 | INHERITED FROM: chemical hypersensitive || cadmium response variant || chemical response variant || colchicine hypersensitive || RNAi response variant || cadmium hypersensitive || RNAi resistant || metal response variant |
| ARM repeat | 0.02104 | INHERITED FROM: protein expression variant || gene expression variant || sexually dimorphic physiology variant || sick || RNAi response variant || organism metabolism processing variant |
| Protein kinase-like (PK-like) | 0.03839 | INHERITED FROM: protein expression variant || organism environmental stimulus response variant || conflicting sensory integration variant || metabolic pathway variant || copper hypersensitive || colchicine resistant || protein subcellular localization variant || positive chemotaxis variant || kinase activity reduced || chemical response variant || anoxia resistant || drug induced gene expression variant || egg laying response to food variant || life span variant || protein modification variant || aqueous chemosensory response variant || second messenger mediated signaling variant || lipid synthesis increased || mid larval arrest || alkaline pH chemotaxis variant || protein phosphorylation variant || transgene expression reduced || hypoxia response variant || mechanosensation variant || organism oxidative stress response variant || protein phosphorylation reduced || aldicarb response variant || organism osmotic stress hypersensitive || octanol chemotaxis defective || dauer development variant || metal response variant |
| Nucleic acid-binding proteins | 0.04851 | INHERITED FROM: organism environmental stimulus response variant || hermaphrodite physiology variant || sexually dimorphic physiology variant || sick || hydroxyurea hypersensitive || nonsense mRNA accumulation || mRNA surveillance defective || hydroxyurea response variant || avoids bacterial lawn || hypoxia resistant |
| SH3-domain | 0.04851 | INHERITED FROM: protein expression variant || protein expression reduced || protein phosphorylation variant || protein metabolism variant || aldicarb response variant |
| Homeodomain-like | 0.05532 | INHERITED FROM: level of transgene expression variant || adrenergic receptor antagonist response variant || phentolamine resistant || carbon dioxide response variant || egg laying imipramine resistant || growth rate variant || ectopic expression transgene || protein degradation variant || organism metabolism processing variant || carbon dioxide avoidance variant || imipramine resistant |
| WD40 repeat-like | 0.06563 | INHERITED FROM: pathogen induced antimicrobial gene expression variant || osmotic avoidance variant || hermaphrodite physiology variant || sexually dimorphic physiology variant || protein aggregation induced behavior variant || early larval arrest || protein protein interaction variant || protein aggregation variant || organism metabolism processing variant || late larval arrest || aldicarb response variant |
| CCCH zinc finger | 0.07001 | INHERITED FROM: transgene expression variant || gene expression variant || ectopic expression transgene || mRNA expression ectopic |
| FYVE/PHD zinc finger | 0.07992 | INHERITED FROM: protein methylation variant || gene expression variant || organism UV response variant || protein modification variant || organism UV hypersensitive || organism metabolism processing variant |
| Translation proteins | 0.08703 | INHERITED FROM: transgene expression variant || oocyte physiology variant || mRNA levels increased || gene expression variant || receptor mediated endocytosis defective || hermaphrodite physiology variant || sexually dimorphic physiology variant || protein phosphorylation increased || protein phosphorylation variant || proteasome core activity variant || protein protein interaction variant || protein aggregation variant || organism metabolism processing variant |
| "Winged helix" DNA-binding domain | 0.09848 | INHERITED FROM: spontaneous mutation rate increased || protein expression increased || life span variant || protein aggregation induced behavior variant || anesthetic response variant || germline transgene silencing variant || protein protein interaction variant || protein aggregation variant || organism metabolism processing variant |
| HLH, helix-loop-helix DNA-binding domain | 0.1021 | INHERITED FROM: pathogen resistance increased || fungal resistance increased || RNA expression variant || aqueous positive chemotaxis defective || gene expression level reduced || ectopic expression transgene || hypoxia response variant || lysine chemotaxis defective || organism metabolism processing variant |
| Nucleotide cyclase | 0.1021 | INHERITED FROM: bromide chemotaxis variant || organism environmental stimulus response variant || magnesium chemotaxis defective || lithium chemotaxis defective || positive chemotaxis variant || osmotic avoidance variant || diacetyl chemotaxis variant || anion positive chemotaxis variant || anion positive chemotaxis defective || chemical response variant || thermotaxis variant || chemotaxis variant || carbon dioxide response variant || iodide chemotaxis variant || chemosensory response variant || iodide chemotaxis defective || bromide chemotaxis defective || aqueous chemosensory response variant || second messenger mediated signaling variant || cation positive chemotaxis variant || alkaline pH chemotaxis variant || anesthetic response variant || AWC odorant chemotaxis defective || AWC odorant chemotaxis variant || cation positive chemotaxis defective |
| SMAD/FHA domain | 0.1083 | INHERITED FROM: fat content reduced || dauer development variant |
| Calcium ATPase, transmembrane domain M | 0.1208 | INHERITED FROM: drug hypersensitive || nicotine hypersensitive || lipid composition variant |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1347 | INHERITED FROM: drug hypersensitive || nicotine hypersensitive || lipid composition variant |
| Regulator of G-protein signaling, RGS | 0.1347 | INHERITED FROM: negative chemotaxis variant || chemotaxis variant || mechanosensation variant |
| EGF/Laminin | 0.1403 | INHERITED FROM: odorant negative chemotaxis defective || octanol chemotaxis defective || octanol chemotaxis variant |
| Acid proteases | 0.1498 | INHERITED FROM: transgene expression variant || osmotic integrity variant || transgene subcellular localization variant || hypoosmotic shock hypersensitive || gene expression variant || protein protein interaction variant || protein aggregation variant || organism metabolism processing variant || protein interaction variant |
| Calcium ATPase, transduction domain A | 0.1498 | INHERITED FROM: organism environmental stimulus response variant || drug hypersensitive || nicotine hypersensitive |
| Cysteine-rich domain | 0.1588 | INHERITED FROM: thermosensory behavior variant || pathogen induced antimicrobial gene expression variant || protein subcellular localization variant || positive chemotaxis variant || gene expression variant || thermotaxis variant || response to injury variant || acetylcholinesterase inhibitor response variant || drug induced gene expression variant || organism stress response variant || pathogen induced gene expression variant || antimicrobial gene expression variant || odorant chemosensory response variant || odorant positive chemotaxis variant || bacterially unswollen || organism metabolism processing variant || aldicarb response variant |
| Quinoprotein alcohol dehydrogenase-like | 0.1669 | INHERITED FROM: mRNA levels increased || L2 arrest || mid larval arrest || protein degradation variant || hypoxia response variant |
| Multidrug efflux transporter AcrB transmembrane domain | 0.1728 | INHERITED FROM: positive chemotaxis defective || embryo osmotic integrity defective early emb || egg integrity defective early emb || chemotaxis variant || odorant chemosensory response variant || odorant positive chemotaxis defective |
| ClpP/crotonase | 0.1857 | INHERITED FROM: lipid metabolism variant || level of transgene expression variant || fat content variant |
| DBL homology domain (DH-domain) | 0.1857 | INHERITED FROM: organism environmental stimulus response variant || pathogen resistance increased || organism pathogen response variant || bacterially unswollen || response to bacteria variant || aldicarb response variant |
| HMG-box | 0.1857 | INHERITED FROM: transgene expression variant || anesthetic response variant || maintenance of gene silencing variant |
| Cytochrome P450 | 0.1886 | INHERITED FROM: cadmium response variant || metabolite content decreased || cadmium hypersensitive || metal response variant |
| (Trans)glycosidases | 0.1994 | INHERITED FROM: pathogen susceptibility increased |
| Ankyrin repeat | 0.2154 | INHERITED FROM: organism heat response variant || chemotaxis variant || chemosensory response variant || odorant negative chemotaxis defective || octanol chemotaxis defective || octanol chemotaxis variant |
| Cyclin-like | 0.2409 | INHERITED FROM: protein phosphorylation variant || protein phosphorylation reduced |
| Cysteine proteinases | 0.2516 | INHERITED FROM: paraquat hypersensitive || osmotic integrity variant || hypoosmotic shock hypersensitive || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || organism metabolism processing variant || protein interaction variant |
| Tudor/PWWP/MBT | 0.2544 | INHERITED FROM: pattern of transgene expression variant |
| Bromodomain | 0.2544 | INHERITED FROM: anesthetic resistant || gene expression variant || organism UV response variant || acute functional tolerance to alcohol defective || sick || anesthetic response variant || ethanol resistant || drug adaptation variant || organism UV hypersensitive || organism metabolism processing variant |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2544 | INHERITED FROM: lipid metabolism variant || fat content variant |
| POZ domain | 0.2728 | INHERITED FROM: resistant to protein aggregation induced paralysis || L1 arrest || protein aggregation induced behavior variant || early larval arrest |
| SNARE-like | 0.2824 | INHERITED FROM: transgene expression variant || transgene subcellular localization variant || acetylcholinesterase inhibitor resistant || gene expression variant || sick || aldicarb resistant || pattern of transgene expression variant || organism metabolism processing variant |
| Lipocalins | 0.2826 | INHERITED FROM: paraquat hypersensitive || lipid metabolism variant || fat content increased || fat content variant |
| Metallo-dependent phosphatases | 0.2883 | INHERITED FROM: radiation induced germ cell apoptosis variant || germ cell resistant ionizing radiation |
| RNA-binding domain, RBD | 0.3043 | INHERITED FROM: innate immune response variant || pathogen induced antimicrobial gene expression variant || mRNA export variant || no induction of antimicrobial peptide expression after infection || starvation induced apoptosis variant || RNA metabolism variant || RNA processing variant || sick || RNA expression variant || maintenance of gene silencing variant || alternative splicing variant || organism metabolism processing variant |
| DNA/RNA polymerases | 0.3134 | INHERITED FROM: organism UV response variant || DNA metabolism variant || organism UV hypersensitive |
| PX domain | 0.3469 | INHERITED FROM: protein expression variant || protein subcellular localization variant || protein expression reduced |
| Translation proteins SH3-like domain | 0.3469 | INHERITED FROM: organism environmental stimulus response variant || transgene expression variant || gene expression variant || early larval arrest || organism metabolism processing variant || avoids bacterial lawn || response to bacteria variant |
| Cation efflux protein transmembrane domain-like | 0.3469 | INHERITED FROM: cadmium hypersensitive || manganese response variant || metal response variant || manganese toxicity resistant |
| HAD-like | 0.3705 | INHERITED FROM: nicotine hypersensitive |
| Nicotinic receptor ligand binding domain-like | 0.3863 | INHERITED FROM: drug response variant || organism environmental stimulus response variant || slowing response on food variant || antihelmintic response variant || DMPP resistant || thermosensory behavior variant || cholinergic agonist resistant || hypoosmotic shock hypersensitive || DMPP response variant || selenium response variant || positive chemotaxis variant || nicotine resistant || chemical response variant || thermotaxis variant || benzaldehyde chemotaxis variant || chemosensory response variant || sodium chloride chemotaxis variant || chemical resistant || mechanosensation variant || AWC odorant chemotaxis variant |
| PLP-dependent transferases | 0.3926 | INHERITED FROM: radiation induced germ cell apoptosis variant || germ cell resistant ionizing radiation |
| Ubiquitin-like | 0.4027 | INHERITED FROM: heteroplasmy || protein protein interaction variant || protein aggregation variant || protein interaction variant |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.4229 | INHERITED FROM: drug response variant || organism environmental stimulus response variant || slowing response on food variant || antihelmintic response variant || DMPP resistant || thermosensory behavior variant || cholinergic agonist resistant || hypoosmotic shock hypersensitive || DMPP response variant || selenium response variant || positive chemotaxis variant || nicotine resistant || chemical response variant || thermotaxis variant || benzaldehyde chemotaxis variant || chemosensory response variant || sodium chloride chemotaxis variant || chemical resistant || mechanosensation variant || AWC odorant chemotaxis variant |
| FKBP-like | 0.4236 | INHERITED FROM: transgene subcellular localization variant || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || protein interaction variant |
| HD-domain/PDEase-like | 0.4236 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant || organism temperature response variant |
| RNI-like | 0.4258 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| Class II aaRS and biotin synthetases | 0.4413 | INHERITED FROM: oxygen response variant || organism environmental stimulus response variant || transgene expression variant || oocyte physiology variant || gene expression variant || receptor mediated endocytosis defective || hermaphrodite physiology variant || sexually dimorphic physiology variant || hypoxia response variant || organism metabolism processing variant || avoids bacterial lawn || response to bacteria variant || hypoxia resistant |
| Hect, E3 ligase catalytic domain | 0.4686 | INHERITED FROM: transgene expression variant || transgene subcellular localization variant || germ cell ionizing radiation response variant || gene expression variant || cell ionizing radiation response variant || protein aggregation induced behavior variant || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || organism metabolism processing variant || protein interaction variant |
| DHS-like NAD/FAD-binding domain | 0.4686 | INHERITED FROM: metabolic pathway variant || protein acetylation variant |
| Myosin rod fragments | 0.4686 | INHERITED FROM: hermaphrodite physiology variant || drug resistant || sexually dimorphic physiology variant |
| PRTase-like | 0.4686 | INHERITED FROM: Fluorouracil resistant || drug resistant |
| Ribosomal protein S5 domain 2-like | 0.5025 | INHERITED FROM: early larval arrest |
| Galactose-binding domain-like | 0.5025 | INHERITED FROM: protein protein interaction variant || protein aggregation variant || protein interaction variant |
| Cystine-knot cytokines | 0.5054 | INHERITED FROM: nicotine response variant || levamisole response variant |
| Sm-like ribonucleoproteins | 0.5054 | INHERITED FROM: transgene expression variant || protein subcellular localization variant || organism heat response variant || receptor mediated endocytosis defective || hermaphrodite physiology variant || sexually dimorphic physiology variant || sick || life span variant || pattern of transgene expression variant || unfolded protein response variant || avoids bacterial lawn || response to bacteria variant |
| SH2 domain | 0.5147 | INHERITED FROM: protein expression variant || protein expression reduced || level of protein expression variant |
| Calpain large subunit, middle domain (domain III) | 0.5152 | INHERITED FROM: metabolic pathway variant || protein degradation variant || protein metabolism variant |
| Riboflavin synthase domain-like | 0.5152 | INHERITED FROM: pattern protein expression variant |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.5152 | INHERITED FROM: pattern protein expression variant |
| FAD/NAD(P)-binding domain | 0.5317 | INHERITED FROM: ATP levels reduced || organism toxic chemical response variant || life span variant || pesticide response variant || organism oxidative stress response variant || ATP levels variant |
| WW domain | 0.5418 | INHERITED FROM: maintenance of gene silencing variant || aldicarb resistant |
| FAD-linked reductases, C-terminal domain | 0.5418 | INHERITED FROM: life span variant |
| Voltage-gated potassium channels | 0.5497 | INHERITED FROM: positive chemotaxis defective || adrenergic receptor antagonist response variant || phentolamine resistant || growth rate variant || serotonin response variant || serotonin resistant || protein degradation variant || mechanosensation variant || imipramine resistant |
| Nucleotidylyl transferase | 0.5508 | INHERITED FROM: oxygen response variant || organism environmental stimulus response variant || transgene expression increased || paraquat resistant || hypoxia response variant || organism metabolism processing variant || avoids bacterial lawn || response to bacteria variant || hypoxia resistant |
| SAM/Pointed domain | 0.5508 | INHERITED FROM: gene expression level reduced || aldicarb response variant |
| UBC-like | 0.5542 | INHERITED FROM: transgene subcellular localization variant || sick || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || organism metabolism processing variant || protein interaction variant || late larval arrest |
| SET domain | 0.5542 | INHERITED FROM: dosage compensation variant || protein methylation variant || spontaneous mutation rate increased || gene expression variant || ectopic expression antibody || life span variant || protein modification variant || maintenance of gene silencing variant || RNAi response variant || pattern of transgene expression variant || organism metabolism processing variant || protein metabolism variant || histone methylation variant || shortened life span |
| Seven-hairpin glycosidases | 0.57 | INHERITED FROM: extended life span || protein protein interaction variant || protein aggregation variant |
| Multidrug resistance efflux transporter EmrE | 0.577 | INHERITED FROM: pathogen resistance increased || bacterially unswollen || response to bacteria variant |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.6146 | INHERITED FROM: protein expression variant || organism environmental stimulus response variant || somatic sheath physiology variant || pathogen induced antimicrobial gene expression variant || protein subcellular localization variant || cell stress response variant || chemical response variant || response to injury variant || drug resistant || drug induced gene expression variant || aging variant || growth rate variant || chemical resistant || gonad sheath contractions variant || cellular osmotic stress response variant || RNAi response variant || organism osmotic stress response variant || gonad sheath contraction rate reduced |
| KA1-like | 0.6253 | INHERITED FROM: RNA expression variant |
| Di-copper centre-containing domain | 0.6253 | INHERITED FROM: germ cell ionizing radiation response variant || cell stress response variant || organism ionizing radiation response variant || cell ionizing radiation response variant |
| Nucleotide-binding domain | 0.6253 | INHERITED FROM: extended life span |
| HIT/MYND zinc finger-like | 0.6534 | INHERITED FROM: pattern of transgene expression variant |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.6626 | INHERITED FROM: organism gamma ray response variant || gamma ray induced apoptosis increased || cell gamma ray response variant |
| MFS general substrate transporter | 0.6635 | INHERITED FROM: organism high sodium chloride hypersensitive |
| 4Fe-4S ferredoxins | 0.6899 | INHERITED FROM: transgene expression increased || life span variant |
| S15/NS1 RNA-binding domain | 0.6899 | INHERITED FROM: transgene expression increased || avoids bacterial lawn || response to bacteria variant |
| Frizzled cysteine-rich domain | 0.6899 | INHERITED FROM: transgene expression reduced || antibody staining variant |
| GST C-terminal domain-like | 0.7031 | INHERITED FROM: organism environmental stimulus response variant || enzyme activity reduced || organism heat hypersensitive || enzyme activity variant || organism stress response variant || organism electrophilic stress hypersensitive || cadmium hypersensitive || metal response variant |
| ADC-like | 0.7586 | INHERITED FROM: metabolic pathway variant || transgene expression reduced || protein protein interaction variant || protein aggregation variant || protein metabolism variant || protein interaction variant |
| MIT domain | 0.7586 | INHERITED FROM: protein protein interaction variant || protein aggregation variant || protein interaction variant |
| alpha/beta-Hydrolases | 0.7645 | INHERITED FROM: acetylcholinesterase activity variant || acetylcholinesterase reduced |
| EF-hand | 0.7661 | INHERITED FROM: somatic sheath physiology variant || gonad sheath contractions variant || cellular osmotic stress response variant || protein aggregation variant || protein interaction variant || aldicarb response variant |
| Clavaminate synthase-like | 0.8138 | INHERITED FROM: protein methylation variant || life span variant || histone methylation variant |
| Ribonuclease H-like | 0.8165 | INHERITED FROM: RNAi enhanced || siRNA expression variant || 21U RNA expression variant || somatic transgene silencing variant || RNA expression variant || maintenance of gene silencing variant || RNAi response variant |
| NAD kinase/diacylglycerol kinase-like | 0.8165 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
| CoA-dependent acyltransferases | 0.8267 | INHERITED FROM: organism metabolism processing variant || dauer development variant |
| Cyclophilin-like | 0.8267 | INHERITED FROM: transgene expression variant || transgene subcellular localization variant || gene expression variant || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || protein interaction variant |
| UBA-like | 0.838 | INHERITED FROM: protein protein interaction variant || protein aggregation variant |
| SNF-like | 0.8568 | INHERITED FROM: drug hypersensitive |
| Leucine zipper domain | 0.8635 | INHERITED FROM: mRNA levels reduced || level of transgene expression variant || pathogen susceptibility increased || pore forming toxin response variant || transgene expression reduced || mRNA expression variant |
| GTPase activation domain, GAP | 0.8728 | INHERITED FROM: protein expression variant |
| Eukaryotic type KH-domain (KH-domain type I) | 0.8728 | INHERITED FROM: RNA expression variant |
| Thioredoxin-like | 0.9067 | INHERITED FROM: enzyme activity reduced || organism heat hypersensitive || organism toxic chemical response variant || enzyme activity variant || organism stress response variant || paraquat response variant || organism electrophilic stress hypersensitive || metal response variant |
| p53-like transcription factors | 0.9113 | INHERITED FROM: gene expression level reduced || ectopic expression transgene |
| Immunoglobulin | 0.9182 | INHERITED FROM: growth rate variant || protein degradation variant || aldicarb response variant |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.9201 | INHERITED FROM: dauer resistance to harsh conditions variant || SDS sensitive dauer || level of transgene expression variant || fat content increased || gene expression level reduced || transgene expression reduced || gene expression level high |
| Ribonuclease PH domain 2-like | 0.936 | INHERITED FROM: early larval arrest |
| Nucleotide-diphospho-sugar transferases | 0.9403 | INHERITED FROM: lectin response variant || resistant to lectin |
| Saposin | 0.9619 | INHERITED FROM: germ cell ionizing radiation response variant || radiation induced germ cell apoptosis variant || level of transgene expression variant || germ cell resistant ionizing radiation || transgene expression reduced || pathogen load variant || increased pathogen survival |
| PAZ domain | 0.9948 | INHERITED FROM: mRNA levels increased || RNAi enhanced || siRNA expression variant || 21U RNA expression variant || somatic transgene silencing variant || RNA expression variant || maintenance of gene silencing variant || RNAi response variant |
| Snake toxin-like | 1 | INHERITED FROM: fat content reduced |
| Ligand-binding domain in the NO signalling and Golgi transport | 1 | INHERITED FROM: drug response variant || chemical response variant || carbon dioxide response variant || anesthetic response variant || carbon dioxide avoidance variant |
| RING/U-box | 1 | INHERITED FROM: transgene subcellular localization variant || germ cell ionizing radiation response variant || gene expression variant || cell stress response variant || organism ionizing radiation response variant || cell ionizing radiation response variant || germ cell hypersensitive ionizing radiation || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || organism metabolism processing variant || protein interaction variant |
| beta-beta-alpha zinc fingers | 1 | INHERITED FROM: egg laying imipramine resistant || inhibitor of serotonin uptake variant || organism metabolism processing variant || imipramine resistant |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: locomotion rate serotonin variant || serotonin induced pumping variant || male tail curling serotonin variant || serotonin induced fat reduction variant |
| B-box zinc-binding domain | 1 | INHERITED FROM: transgene expression variant || transgene subcellular localization variant || gene expression variant || protein protein interaction variant || protein aggregation variant || protein interaction variant |
| F-box domain | 1 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: dauer resistance to harsh conditions variant || SDS sensitive dauer || level of transgene expression variant || fat content increased || gene expression level reduced || transgene expression reduced || gene expression level high |
| Bet v1-like | 1 | INHERITED FROM: growth rate variant |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Doublecortin (DC) | 0 | Direct |
| GAT-like domain | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| NagB/RpiA/CoA transferase-like | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Retrovirus zinc finger-like domains | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| FF domain | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| ARID-like | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Glutathione synthetase ATP-binding domain-like | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Molybdenum cofactor biosynthesis proteins | 0 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| Tubby C-terminal domain-like | 0 | Direct |
| Annexin | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Aldolase | 0 | Direct |
| HCP-like | 0 | Direct |
| DEATH domain | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| FAD-linked oxidases, C-terminal domain | 0 | Direct |
| alpha/beta knot | 0 | Direct |
| Tim10-like | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | Direct |
| PK beta-barrel domain-like | 0 | Direct |
| eIF4e-like | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | Direct |
| WWE domain | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| Pepsin inhibitor-3 | 0 | Direct |
| Pentein | 0 | Direct |
| Elafin-like | 0 | Direct |
| Invertebrate chitin-binding proteins | 0 | Direct |
| ALDH-like | 0 | Direct |
| ArfGap/RecO-like zinc finger | 0 | Direct |
| Cytochrome c | 0 | Direct |
| Carbon-nitrogen hydrolase | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| GroES-like | 0 | Direct |
| t-snare proteins | 0 | Direct |
| Outer arm dynein light chain 1 | 0 | Direct |
| GroEL-intermediate domain like | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| Ribosomal L27 protein-like | 0 | Direct |
| PIN domain-like | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| GroEL equatorial domain-like | 0 | Direct |
| Nucleotidyltransferase | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| MIR domain | 0 | Direct |
| Cullin repeat-like | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
| Fibrinogen C-terminal domain-like | 0 | Direct |
| WGR domain-like | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
| Band 7/SPFH domain | 0 | Direct |
| Ferritin-like | 0 | Direct |
| Diaminopimelate epimerase-like | 0 | Direct |
| FAD-binding/transporter-associated domain-like | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| Carbohydrate phosphatase | 0 | Direct |
| Chromo domain-like | 0 | Direct |
| LDH C-terminal domain-like | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| LEM domain | 0 | Direct |
| Citrate synthase | 0 | Direct |
| YWTD domain | 0 | Direct |
| MgtE membrane domain-like | 0 | Direct |
| ENTH/VHS domain | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| ADP-ribosylation | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
| Hedgehog/intein (Hint) domain | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| Nucleoside diphosphate kinase, NDK | 0 | Direct |
| lambda repressor-like DNA-binding domains | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| Acetyl-CoA synthetase-like | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Ran binding protein zinc finger-like | 0 | Direct |
| Periplasmic binding protein-like II | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| CBD9-like | 0 | Direct |
| Kringle-like | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
| PUA domain-like | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| CAD & PB1 domains | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| SIS domain | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| Phoshotransferase/anion transport protein | 0 | Direct |
| ACP-like | 0 | Direct |
| HSP20-like chaperones | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| Radical SAM enzymes | 0 | Direct |
| VPS9 domain | 0 | Direct |
| Families 57/38 glycoside transferase middle domain | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| Oxysterol-binding protein-like | 0 | Direct |
| Cystatin/monellin | 0 | Direct |
| Polo-box domain | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| dsRNA-binding domain-like | 0 | Direct |
| Intermediate filament protein, coiled coil region | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| GYF domain | 0 | Direct |
| Histone-fold | 0 | Direct |
| Profilin (actin-binding protein) | 0 | Direct |
| LysM domain | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| Terpenoid synthases | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Galactose mutarotase-like | 0 | Direct |
| Cadherin-like | 0 | Direct |
| PEBP-like | 0 | Direct |
| BEACH domain | 0 | Direct |
| Skp1 dimerisation domain-like | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| Clc chloride channel | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| Spectrin repeat | 0 | Direct |
| Composite domain of metallo-dependent hydrolases | 0 | Direct |
| beta-lactamase/transpeptidase-like | 0 | Direct |
| Sec63 N-terminal domain-like | 0 | Direct |
| Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| ISP domain | 0 | Direct |
| Nop domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| MFPT repeat-like | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| ThrRS/AlaRS common domain | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| PreATP-grasp domain | 0 | Direct |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| Ribokinase-like | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Protease propeptides/inhibitors | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| Translational machinery components | 0 | Direct |
| PYP-like sensor domain (PAS domain) | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| SAICAR synthase-like | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| Chitinase insertion domain | 0 | Direct |
| Glycolipid transfer protein, GLTP | 0 | Direct |
| Ribosomal protein S18 | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
| Galactose oxidase, central domain | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| SAND domain-like | 0 | Direct |
| Insulin-like | 0 | Direct |
| PGBD-like | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| GroEL apical domain-like | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
| TGS-like | 0 | Direct |
| Sec7 domain | 0 | Direct |
| Hypothetical protein c14orf129, hspc210 | 0 | Direct |
| GAS2 domain-like | 0 | Direct |
| cAMP-binding domain-like | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| Tubulin nucleotide-binding domain-like | 0 | Direct |
| HRDC-like | 0 | Direct |
| Carboxypeptidase regulatory domain-like | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| L30e-like | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| Integrin domains | 0 | Direct |
| Actin-like ATPase domain | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| SCP-like | 0 | Direct |
| Thiolase-like | 0 | Direct |
| PHM/PNGase F | 0 | Direct |
| YbiA-like | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| Tricorn protease domain 2 | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| PAP/OAS1 substrate-binding domain | 0 | Direct |
| R3H domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0.0000004141 | Direct |
| PH domain-like | 0.00002159 | Direct |
| PapD-like | 0.009043 | Inherited |
| PDZ domain-like | 0.009221 | Inherited |
| TPR-like | 0.01305 | Inherited |
| Periplasmic binding protein-like I | 0.01452 | Inherited |
| ABC transporter transmembrane region | 0.02042 | Inherited |
| ARM repeat | 0.02104 | Inherited |
| Protein kinase-like (PK-like) | 0.03839 | Inherited |
| Nucleic acid-binding proteins | 0.04851 | Inherited |
| SH3-domain | 0.04851 | Inherited |
| Homeodomain-like | 0.05532 | Inherited |
| WD40 repeat-like | 0.06563 | Inherited |
| CCCH zinc finger | 0.07001 | Inherited |
| FYVE/PHD zinc finger | 0.07992 | Inherited |
| Translation proteins | 0.08703 | Inherited |
| "Winged helix" DNA-binding domain | 0.09848 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.1021 | Inherited |
| Nucleotide cyclase | 0.1021 | Inherited |
| SMAD/FHA domain | 0.1083 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.1208 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1347 | Inherited |
| Regulator of G-protein signaling, RGS | 0.1347 | Inherited |
| EGF/Laminin | 0.1403 | Inherited |
| Acid proteases | 0.1498 | Inherited |
| Calcium ATPase, transduction domain A | 0.1498 | Inherited |
| Cysteine-rich domain | 0.1588 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.1669 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.1728 | Inherited |
| ClpP/crotonase | 0.1857 | Inherited |
| DBL homology domain (DH-domain) | 0.1857 | Inherited |
| HMG-box | 0.1857 | Inherited |
| Cytochrome P450 | 0.1886 | Inherited |
| (Trans)glycosidases | 0.1994 | Inherited |
| Ankyrin repeat | 0.2154 | Inherited |
| Cyclin-like | 0.2409 | Inherited |
| Cysteine proteinases | 0.2516 | Inherited |
| Tudor/PWWP/MBT | 0.2544 | Inherited |
| Bromodomain | 0.2544 | Inherited |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2544 | Inherited |
| POZ domain | 0.2728 | Inherited |
| SNARE-like | 0.2824 | Inherited |
| Lipocalins | 0.2826 | Inherited |
| Metallo-dependent phosphatases | 0.2883 | Inherited |
| RNA-binding domain, RBD | 0.3043 | Inherited |
| DNA/RNA polymerases | 0.3134 | Inherited |
| PX domain | 0.3469 | Inherited |
| Translation proteins SH3-like domain | 0.3469 | Inherited |
| Cation efflux protein transmembrane domain-like | 0.3469 | Inherited |
| HAD-like | 0.3705 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.3863 | Inherited |
| PLP-dependent transferases | 0.3926 | Inherited |
| Ubiquitin-like | 0.4027 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.4229 | Inherited |
| FKBP-like | 0.4236 | Inherited |
| HD-domain/PDEase-like | 0.4236 | Inherited |
| RNI-like | 0.4258 | Inherited |
| Class II aaRS and biotin synthetases | 0.4413 | Inherited |
| Hect, E3 ligase catalytic domain | 0.4686 | Inherited |
| DHS-like NAD/FAD-binding domain | 0.4686 | Inherited |
| Myosin rod fragments | 0.4686 | Inherited |
| PRTase-like | 0.4686 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.5025 | Inherited |
| Galactose-binding domain-like | 0.5025 | Inherited |
| Cystine-knot cytokines | 0.5054 | Inherited |
| Sm-like ribonucleoproteins | 0.5054 | Inherited |
| SH2 domain | 0.5147 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.5152 | Inherited |
| Riboflavin synthase domain-like | 0.5152 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.5152 | Inherited |
| FAD/NAD(P)-binding domain | 0.5317 | Inherited |
| WW domain | 0.5418 | Inherited |
| FAD-linked reductases, C-terminal domain | 0.5418 | Inherited |
| Voltage-gated potassium channels | 0.5497 | Inherited |
| Nucleotidylyl transferase | 0.5508 | Inherited |
| SAM/Pointed domain | 0.5508 | Inherited |
| UBC-like | 0.5542 | Inherited |
| SET domain | 0.5542 | Inherited |
| Seven-hairpin glycosidases | 0.57 | Inherited |
| Multidrug resistance efflux transporter EmrE | 0.577 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.6146 | Inherited |
| KA1-like | 0.6253 | Inherited |
| Di-copper centre-containing domain | 0.6253 | Inherited |
| Nucleotide-binding domain | 0.6253 | Inherited |
| HIT/MYND zinc finger-like | 0.6534 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.6626 | Inherited |
| MFS general substrate transporter | 0.6635 | Inherited |
| 4Fe-4S ferredoxins | 0.6899 | Inherited |
| S15/NS1 RNA-binding domain | 0.6899 | Inherited |
| Frizzled cysteine-rich domain | 0.6899 | Inherited |
| GST C-terminal domain-like | 0.7031 | Inherited |
| ADC-like | 0.7586 | Inherited |
| MIT domain | 0.7586 | Inherited |
| alpha/beta-Hydrolases | 0.7645 | Inherited |
| EF-hand | 0.7661 | Inherited |
| Clavaminate synthase-like | 0.8138 | Inherited |
| Ribonuclease H-like | 0.8165 | Inherited |
| NAD kinase/diacylglycerol kinase-like | 0.8165 | Inherited |
| CoA-dependent acyltransferases | 0.8267 | Inherited |
| Cyclophilin-like | 0.8267 | Inherited |
| UBA-like | 0.838 | Inherited |
| SNF-like | 0.8568 | Inherited |
| Leucine zipper domain | 0.8635 | Inherited |
| GTPase activation domain, GAP | 0.8728 | Inherited |
| Eukaryotic type KH-domain (KH-domain type I) | 0.8728 | Inherited |
| Thioredoxin-like | 0.9067 | Inherited |
| p53-like transcription factors | 0.9113 | Inherited |
| Immunoglobulin | 0.9182 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.9201 | Inherited |
| Ribonuclease PH domain 2-like | 0.936 | Inherited |
| Nucleotide-diphospho-sugar transferases | 0.9403 | Inherited |
| Saposin | 0.9619 | Inherited |
| PAZ domain | 0.9948 | Inherited |
| Snake toxin-like | 1 | Inherited |
| Ligand-binding domain in the NO signalling and Golgi transport | 1 | Inherited |
| RING/U-box | 1 | Inherited |
| beta-beta-alpha zinc fingers | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
| B-box zinc-binding domain | 1 | Inherited |
| F-box domain | 1 | Inherited |
| Nuclear receptor ligand-binding domain | 1 | Inherited |
| Bet v1-like | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Chitinase insertion domain | 0 | DIRECT |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Pyk2-associated protein beta ARF-GAP domain | 0 | DIRECT |
| GAPDH-like | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Ras-binding domain, RBD | 0 | DIRECT |
| Myeloperoxidase-like | 0 | DIRECT |
| POU-specific domain | 0 | DIRECT |
| Matrix metalloproteases, catalytic domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| PDI-like | 0 | DIRECT |
| D-aminoacid oxidase-like | 0 | DIRECT |
| Thiolase-related | 0 | DIRECT |
| Ran binding protein zinc finger-like | 0 | DIRECT |
| Amylase, catalytic domain | 0 | DIRECT |
| CAT-like | 0 | DIRECT |
| Reductases | 0 | DIRECT |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | DIRECT |
| alpha-mannosidase | 0 | DIRECT |
| BAR domain | 0 | DIRECT |
| Ubiquitin activating enzymes (UBA) | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| Dual specificity phosphatase-like | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| DPP6 catalytic domain-like | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| Internalin LRR domain | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
| Phosphotyrosine-binding domain (PTB) | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| Calcium ATPase, transmembrane domain M | 0 | DIRECT |
| a tRNA synthase domain | 0 | DIRECT |
| PEP carboxykinase C-terminal domain | 0 | DIRECT |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | DIRECT |
| Sir2 family of transcriptional regulators | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | DIRECT |
| La domain | 0 | DIRECT |
| t-snare proteins | 0 | DIRECT |
| Pancreatic carboxypeptidase, activation domain | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
| Type II chitinase | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| Brix domain | 0 | DIRECT |
| Anticodon-binding domain | 0 | DIRECT |
| Citrate synthase | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| Cytoplasmic domain of inward rectifier potassium channel | 0 | DIRECT |
| Nucleosome core histones | 0 | DIRECT |
| Intermediate filament protein, coiled coil region | 0 | DIRECT |
| Heme-dependent catalases | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| Tim10/DDP | 0 | DIRECT |
| Pumilio repeat | 0 | DIRECT |
| Third domain of FERM | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Hydantoinase (dihydropyrimidinase) | 0 | DIRECT |
| RhoGDI-like | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| Acetyl-CoA synthetase-like | 0 | DIRECT |
| Spectrin repeat | 0 | DIRECT |
| WGR domain | 0 | DIRECT |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Regulator of G-protein signaling, RGS | 0 | DIRECT |
| SWIRM domain | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| PLC-like (P variant) | 0 | DIRECT |
| Retrovirus zinc finger-like domains | 0 | DIRECT |
| GABA-aminotransferase-like | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| First domain of FERM | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| Ribokinase-like | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| CUT domain | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| Phosphoribosyltransferases (PRTases) | 0 | DIRECT |
| DPP6 N-terminal domain-like | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| ATP-dependent protease Lon (La), catalytic domain | 0 | DIRECT |
| Acylamino-acid-releasing enzyme, C-terminal donain | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | DIRECT |
| Fatty acid binding protein-like | 0 | DIRECT |
| ARID domain | 0 | DIRECT |
| Tubulin, GTPase domain | 0 | DIRECT |
| Polo-box duplicated region | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | DIRECT |
| TBP-associated factors, TAFs | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | DIRECT |
| WWE domain | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| Ribosomal protein L18 and S11 | 0 | DIRECT |
| BC C-terminal domain-like | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| 28-residue LRR | 0 | DIRECT |
| Glycosyl transferases group 1 | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Ferredoxin reductase FAD-binding domain-like | 0 | DIRECT |
| L30e/L7ae ribosomal proteins | 0 | DIRECT |
| XPF/Rad1/Mus81 nuclease | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Sec63 N-terminal domain | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Carboxypeptidase regulatory domain | 0 | DIRECT |
| Fibrinogen C-terminal domain-like | 0 | DIRECT |
| Translation initiation factor eIF4e | 0 | DIRECT |
| Acyl-carrier protein (ACP) | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | DIRECT |
| Cofilin-like | 0 | DIRECT |
| Myotubularin-like phosphatases | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| COMT-like | 0 | DIRECT |
| SCF ubiquitin ligase complex WHB domain | 0 | DIRECT |
| Hexokinase | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| Poly(A) polymerase, PAP, middle domain | 0 | DIRECT |
| HSP20 | 0 | DIRECT |
| Proprotein convertase P-domain | 0 | DIRECT |
| PUA domain | 0 | DIRECT |
| U-box | 0 | DIRECT |
| Band 7/SPFH domain | 0 | DIRECT |
| Tetraspanin | 0 | DIRECT |
| Subtilases | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| Adenosine/AMP deaminase | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| Glycolipid transfer protein, GLTP | 0 | DIRECT |
| MutT-like | 0 | DIRECT |
| Methionine aminopeptidase, insert domain | 0 | DIRECT |
| Vertebrate phospholipase A2 | 0 | DIRECT |
| Clathrin adaptor core protein | 0 | DIRECT |
| acyl-CoA oxidase C-terminal domains | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| GAS2 domain | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | DIRECT |
| Clc chloride channel | 0 | DIRECT |
| Glycogenin | 0 | DIRECT |
| D-aminoacid oxidase, N-terminal domain | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Reprolysin-like | 0 | DIRECT |
| NOL1/NOP2/sun | 0 | DIRECT |
| RNA-polymerase beta | 0 | DIRECT |
| DNA gyrase/MutL, N-terminal domain | 0 | DIRECT |
| Protein prenyltransferases | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| beta-Lactamase/D-ala carboxypeptidase | 0 | DIRECT |
| Eps15 homology domain (EH domain) | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| p120GAP domain-like | 0 | DIRECT |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | DIRECT |
| Calpain large subunit, catalytic domain (domain II) | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| Ngr ectodomain-like | 0 | DIRECT |
| Armadillo repeat | 0 | DIRECT |
| Proteasome subunits | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| Epoxide hydrolase | 0 | DIRECT |
| Acireductone dioxygenase | 0 | DIRECT |
| PhzC/PhzF-like | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Cadherin | 0 | DIRECT |
| Single strand DNA-binding domain, SSB | 0 | DIRECT |
| MFPT repeat | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| PDZ domain | 0 | DIRECT |
| Acyl-CoA thioesterase | 0 | DIRECT |
| Linker histone H1/H5 | 0 | DIRECT |
| Pancreatic carboxypeptidases | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| Histone deacetylase, HDAC | 0 | DIRECT |
| Pepsin inhibitor-3 | 0 | DIRECT |
| Clathrin coat assembly domain | 0 | DIRECT |
| Erythroid transcription factor GATA-1 | 0 | DIRECT |
| Mammalian PLC | 0 | DIRECT |
| Paired domain | 0 | DIRECT |
| Chromo domain | 0 | DIRECT |
| Poly(ADP-ribose) polymerase, C-terminal domain | 0 | DIRECT |
| HEAT repeat | 0 | DIRECT |
| Laminin G-like module | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| DEP domain | 0 | DIRECT |
| acyl-CoA oxidase N-terminal domains | 0 | DIRECT |
| L-aminoacid/polyamine oxidase | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| Regulator of chromosome condensation RCC1 | 0 | DIRECT |
| cAMP-binding domain | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| CoA transferase alpha subunit-like | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0 | DIRECT |
| 1,3-glucuronyltransferase | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| RNA-polymerase beta-prime | 0 | DIRECT |
| LacY-like proton/sugar symporter | 0 | DIRECT |
| DEATH domain, DD | 0 | DIRECT |
| YicI catalytic domain-like | 0 | DIRECT |
| Actin/HSP70 | 0 | DIRECT |
| Trunk domain of Sec23/24 | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Troponin I | 0 | DIRECT |
| Adenain-like | 0 | DIRECT |
| Inositol polyphosphate kinase (IPK) | 0 | DIRECT |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | DIRECT |
| Phosphatidylethanolamine binding protein | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | DIRECT |
| CO dehydrogenase flavoprotein N-terminal domain-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| BC ATP-binding domain-like | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| IF2B-like | 0 | DIRECT |
| Sec63 C-terminal domain-like | 0 | DIRECT |
| Class I aldolase | 0 | DIRECT |
| VHS domain | 0 | DIRECT |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | DIRECT |
| AMPK-beta glycogen binding domain-like | 0 | DIRECT |
| Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | DIRECT |
| Class II glutamine amidotransferases | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | DIRECT |
| HAT/Suf repeat | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| NLI interacting factor-like phosphatase | 0 | DIRECT |
| YbiA-like | 0 | DIRECT |
| Phosphate binding protein-like | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| MIF4G domain-like | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| LDH N-terminal domain-like | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| Sterol carrier protein, SCP | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| HCDH C-domain-like | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| PDEase | 0 | DIRECT |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0 | DIRECT |
| Choline kinase | 0 | DIRECT |
| Elafin-like | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| ets domain | 0 | DIRECT |
| Glycerol kinase | 0 | DIRECT |
| Glutaminase | 0 | DIRECT |
| Bactericidal permeability-increasing protein, BPI | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| Oxysterol-binding protein | 0 | DIRECT |
| Hedgehog C-terminal (Hog) autoprocessing domain | 0 | DIRECT |
| Arylsulfatase | 0 | DIRECT |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| YihX-like | 0 | DIRECT |
| Profilin (actin-binding protein) | 0 | DIRECT |
| 5' to 3' exonuclease catalytic domain | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| Hypothetical protein c14orf129, hspc210 | 0 | DIRECT |
| BC N-terminal domain-like | 0 | DIRECT |
| Glycerophosphoryl diester phosphodiesterase | 0 | DIRECT |
| Tubulin, C-terminal domain | 0 | DIRECT |
| SAM (sterile alpha motif) domain | 0 | DIRECT |
| alpha-mannosidase, domain 2 | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
| RecA protein-like (ATPase-domain) | 0 | DIRECT |
| Gamma-glutamyltranspeptidase-like | 0 | DIRECT |
| Skp1 dimerisation domain-like | 0 | DIRECT |
| CoA-binding domain | 0 | DIRECT |
| UBA domain | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| DNA gyrase/MutL, second domain | 0 | DIRECT |
| UDP-glucose pyrophosphorylase | 0 | DIRECT |
| Ribosomal protein S18 | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | DIRECT |
| FHA domain | 0 | DIRECT |
| Poly(A) polymerase, PAP, C-terminal domain | 0 | DIRECT |
| PaaI/YdiI-like | 0 | DIRECT |
| Filamin repeat (rod domain) | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| HD domain | 0 | DIRECT |
| SAND domain | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| NHL repeat | 0 | DIRECT |
| Pleckstrin-homology domain (PH domain) | 0 | DIRECT |
| beta 1,4 galactosyltransferase (b4GalT1) | 0 | DIRECT |
| Double-stranded RNA-binding domain (dsRBD) | 0 | DIRECT |
| alpha-catenin/vinculin | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| alpha-mannosidase, C-terminal domain | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| Poly(A) polymerase, PAP, N-terminal domain | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Arfaptin, Rac-binding fragment | 0 | DIRECT |
| Arginine methyltransferase | 0 | DIRECT |
| Tandem AAA-ATPase domain | 0.003654 | INHERITED FROM: cell stress response variant || organism UV response variant || sick || organism stress response variant || germline RNAi resistant || RNAi response variant |
| ABC transporter ATPase domain-like | 0.01003 | INHERITED FROM: chemical hypersensitive || cadmium response variant || colchicine hypersensitive || RNAi response variant || cadmium hypersensitive || RNAi resistant || metal response variant |
| MSP-like | 0.02384 | INHERITED FROM: dauer metabolism variant || lipid metabolism variant || fat content variant || dauer lifespan extended || dauer lifespan variant |
| Homeodomain | 0.03701 | INHERITED FROM: level of transgene expression variant || carbon dioxide response variant || ectopic expression transgene || anesthetic response variant || organism metabolism processing variant || carbon dioxide avoidance variant |
| ABC transporter transmembrane region | 0.04247 | INHERITED FROM: chemical hypersensitive || cadmium response variant || colchicine hypersensitive || RNAi response variant || cadmium hypersensitive || RNAi resistant || metal response variant |
| WD40-repeat | 0.04718 | INHERITED FROM: pathogen induced antimicrobial gene expression variant || osmotic avoidance variant || ivermectin resistant || protein aggregation induced behavior variant || dauer defective || ivermectin response variant |
| G proteins | 0.04739 | INHERITED FROM: drug response variant || organism environmental stimulus response variant || osmotic integrity variant || protein subcellular localization variant || hermaphrodite physiology variant || chemotaxis variant || sexually dimorphic physiology variant || drug induced gene expression variant || chemosensory response variant || fat content variant || anesthetic response variant || protein phosphorylation variant || cellular osmotic stress response variant || organism metabolism processing variant || protein metabolism variant || aldicarb response variant || carbon dioxide avoidance variant || pathogen release variant |
| L-arabinose binding protein-like | 0.05747 | INHERITED FROM: bromide chemotaxis variant || organism environmental stimulus response variant || magnesium chemotaxis defective || thermosensory behavior variant || lithium chemotaxis defective || anion positive chemotaxis variant || anion positive chemotaxis defective || thermotaxis variant || chemotaxis variant || iodide chemotaxis variant || chemosensory response variant || iodide chemotaxis defective || bromide chemotaxis defective || cation positive chemotaxis variant || alkaline pH chemotaxis variant || organism temperature response variant || aqueous positive chemotaxis variant || cation positive chemotaxis defective |
| Protein kinases, catalytic subunit | 0.06104 | INHERITED FROM: protein expression variant || oxygen response variant || conflicting sensory integration variant || copper hypersensitive || colchicine resistant || anoxia response variant || protein subcellular localization variant || positive chemotaxis variant || kinase activity reduced || chemical response variant || anoxia resistant || drug induced gene expression variant || egg laying response to food variant || protein modification variant || second messenger mediated signaling variant || lipid synthesis increased || alkaline pH chemotaxis variant || protein phosphorylation variant || transgene expression reduced || hypoxia response variant || mechanosensation variant || protein phosphorylation reduced || aldicarb response variant || octanol chemotaxis defective || dauer development variant || metal response variant |
| SH3-domain | 0.07439 | INHERITED FROM: protein expression variant || protein expression reduced || aldicarb response variant |
| CCCH zinc finger | 0.08576 | INHERITED FROM: transgene expression variant || gene expression variant || ectopic expression transgene || mRNA expression ectopic |
| Canonical RBD | 0.1018 | INHERITED FROM: innate immune response variant || pathogen induced antimicrobial gene expression variant || mRNA export variant || no induction of antimicrobial peptide expression after infection || starvation induced apoptosis variant || RNA metabolism variant || RNA processing variant || sick || RNA expression variant || organism metabolism processing variant || late larval arrest |
| Extended AAA-ATPase domain | 0.1044 | INHERITED FROM: spontaneous mutation rate increased || sick || protein expression increased || response to bacteria variant |
| Tetratricopeptide repeat (TPR) | 0.1133 | INHERITED FROM: organism metabolism processing variant |
| Cold shock DNA-binding domain-like | 0.1277 | INHERITED FROM: hermaphrodite physiology variant || RNA metabolism variant || sick || nonsense mRNA accumulation || mRNA surveillance defective |
| Adenylyl and guanylyl cyclase catalytic domain | 0.1328 | INHERITED FROM: bromide chemotaxis variant || organism environmental stimulus response variant || magnesium chemotaxis defective || lithium chemotaxis defective || positive chemotaxis variant || osmotic avoidance variant || diacetyl chemotaxis variant || anion positive chemotaxis defective || chemical response variant || chemotaxis variant || carbon dioxide response variant || iodide chemotaxis variant || chemosensory response variant || iodide chemotaxis defective || bromide chemotaxis defective || aqueous chemosensory response variant || second messenger mediated signaling variant || cation positive chemotaxis variant || alkaline pH chemotaxis variant || anesthetic response variant || AWC odorant chemotaxis defective || AWC odorant chemotaxis variant || cation positive chemotaxis defective |
| Motor proteins | 0.1328 | INHERITED FROM: male response to hermaphrodite variant || sexually dimorphic mechanosensation variant |
| HLH, helix-loop-helix DNA-binding domain | 0.1328 | INHERITED FROM: pathogen resistance increased || fungal resistance increased || RNA expression variant || aqueous positive chemotaxis defective || gene expression level reduced || ectopic expression transgene || lysine chemotaxis defective |
| Calcium ATPase, transduction domain A | 0.1719 | INHERITED FROM: drug hypersensitive || nicotine hypersensitive |
| Cyclin | 0.2094 | INHERITED FROM: level of transgene expression variant |
| DBL homology domain (DH-domain) | 0.2094 | INHERITED FROM: organism environmental stimulus response variant || pathogen resistance increased || organism pathogen response variant || bacterially unswollen || response to bacteria variant || aldicarb response variant |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.2094 | INHERITED FROM: oxygen response variant || organism environmental stimulus response variant || gene expression variant || receptor mediated endocytosis defective || organism toxic chemical response variant || transgene expression increased || paraquat response variant || paraquat resistant || hypoxia response variant || avoids bacterial lawn || response to bacteria variant || hypoxia resistant |
| Elongation factors | 0.2094 | INHERITED FROM: mRNA levels reduced || mRNA levels increased || protein phosphorylation increased || protein phosphorylation variant || proteasome core activity variant || protein protein interaction variant || protein aggregation variant |
| HMG-box | 0.2094 | INHERITED FROM: anesthetic response variant || maintenance of gene silencing variant |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.2094 | INHERITED FROM: oxygen response variant || organism environmental stimulus response variant || transgene expression variant || oocyte physiology variant || gene expression variant || receptor mediated endocytosis defective || hermaphrodite physiology variant || sexually dimorphic physiology variant || hypoxia response variant || organism metabolism processing variant || avoids bacterial lawn || response to bacteria variant || hypoxia resistant |
| Pepsin-like | 0.2306 | INHERITED FROM: transgene expression variant || osmotic integrity variant || transgene subcellular localization variant || hypoosmotic shock hypersensitive || gene expression variant || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || organism metabolism processing variant || protein interaction variant |
| Histone lysine methyltransferases | 0.2306 | INHERITED FROM: protein methylation variant || metabolic pathway variant || gene expression variant || ectopic expression antibody || life span variant || protein modification variant || maintenance of gene silencing variant || mRNA expression variant || RNAi response variant || pattern of transgene expression variant || organism metabolism processing variant || protein metabolism variant || histone methylation variant || shortened life span |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.2539 | INHERITED FROM: organism environmental stimulus response variant || drug hypersensitive || nicotine hypersensitive |
| Forkhead DNA-binding domain | 0.2539 | INHERITED FROM: transgene expression variant || transgene subcellular localization variant || gene expression variant || pattern of transgene expression variant || organism metabolism processing variant |
| DnaQ-like 3'-5' exonuclease | 0.2539 | INHERITED FROM: RNAi response variant |
| Multidrug efflux transporter AcrB transmembrane domain | 0.2651 | INHERITED FROM: positive chemotaxis defective || embryo osmotic integrity defective early emb || egg integrity defective early emb || chemotaxis variant || odorant chemosensory response variant || odorant positive chemotaxis defective |
| Cytochrome P450 | 0.2724 | INHERITED FROM: cadmium response variant || metabolite content decreased || cadmium hypersensitive || metal response variant |
| Bromodomain | 0.2793 | INHERITED FROM: anesthetic resistant || gene expression variant || organism UV response variant || acute functional tolerance to alcohol defective || sick || anesthetic response variant || ethanol resistant || drug adaptation variant || organism UV hypersensitive |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.2793 | INHERITED FROM: lipid metabolism variant || fat content variant |
| Acetylcholinesterase-like | 0.2898 | INHERITED FROM: enzyme activity reduced || acetylcholinesterase activity variant || enzyme activity variant || acetylcholinesterase reduced |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.3079 | INHERITED FROM: organism toxic chemical response variant || pesticide response variant || paraquat response variant || organism oxidative stress response variant |
| Ankyrin repeat | 0.3262 | INHERITED FROM: organism heat response variant || odorant negative chemotaxis defective || octanol chemotaxis defective || octanol chemotaxis variant |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.3262 | INHERITED FROM: drug response variant || organism environmental stimulus response variant || slowing response on food variant || antihelmintic response variant || DMPP resistant || thermosensory behavior variant || cholinergic agonist resistant || hypoosmotic shock hypersensitive || DMPP response variant || selenium response variant || positive chemotaxis variant || nicotine resistant || chemical response variant || thermotaxis variant || benzaldehyde chemotaxis variant || chemosensory response variant || sodium chloride chemotaxis variant || chemical resistant || mechanosensation variant || AWC odorant chemotaxis variant |
| Meta-cation ATPase, catalytic domain P | 0.3387 | INHERITED FROM: nicotine response variant || organism environmental stimulus response variant || nicotine hypersensitive |
| Crotonase-like | 0.3387 | INHERITED FROM: lipid metabolism variant || fat content variant |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.3387 | INHERITED FROM: oocyte physiology variant || protein subcellular localization variant || receptor mediated endocytosis defective || hermaphrodite physiology variant || pattern protein expression variant || sexually dimorphic physiology variant || sick || life span variant || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || avoids bacterial lawn || response to bacteria variant |
| PX domain | 0.3729 | INHERITED FROM: protein expression variant || protein subcellular localization variant |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.4308 | INHERITED FROM: thermosensory behavior variant || pathogen induced antimicrobial gene expression variant || protein subcellular localization variant || gene expression variant || thermotaxis variant || response to injury variant || drug resistant || drug induced gene expression variant || organism stress response variant || pathogen induced gene expression variant || antimicrobial gene expression variant || chemical resistant || nose touch variant || odorant positive chemotaxis variant || organism temperature response variant || aldicarb response variant |
| BTB/POZ domain | 0.4349 | INHERITED FROM: chemical hypersensitive || resistant to protein aggregation induced paralysis || L1 arrest || protein aggregation induced behavior variant || early larval arrest |
| FKBP immunophilin/proline isomerase | 0.4485 | INHERITED FROM: transgene subcellular localization variant || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || protein interaction variant |
| Cation efflux protein transmembrane domain-like | 0.4485 | INHERITED FROM: chemical hypersensitive || cadmium response variant || cadmium hypersensitive || manganese response variant || metal response variant || manganese toxicity resistant |
| PHD domain | 0.4587 | INHERITED FROM: protein methylation variant || organism environmental stimulus response variant || transgene expression variant || transgene subcellular localization variant || gene expression variant || organism UV response variant || protein modification variant || organism UV hypersensitive || organism metabolism processing variant || RNAi resistant |
| Hect, E3 ligase catalytic domain | 0.4902 | INHERITED FROM: transgene expression variant || transgene subcellular localization variant || germ cell ionizing radiation response variant || gene expression variant || cell ionizing radiation response variant || protein aggregation induced behavior variant || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || organism metabolism processing variant || protein interaction variant |
| Myosin rod fragments | 0.4902 | INHERITED FROM: hermaphrodite physiology variant || sexually dimorphic physiology variant |
| Pyridoxal-dependent decarboxylase | 0.4902 | INHERITED FROM: egg laying response to drug variant || carbon dioxide response variant || carbon dioxide avoidance variant |
| Glutathione S-transferase (GST), N-terminal domain | 0.4982 | INHERITED FROM: chemical hypersensitive || enzyme activity reduced || organism heat hypersensitive || organism toxic chemical response variant || enzyme activity variant || organism stress response variant || paraquat response variant || organism electrophilic stress hypersensitive || metal response variant |
| I set domains | 0.5198 | INHERITED FROM: growth rate variant || protein degradation variant || aldicarb response variant |
| Nicotinic receptor ligand binding domain-like | 0.5254 | INHERITED FROM: drug response variant || organism environmental stimulus response variant || slowing response on food variant || antihelmintic response variant || DMPP resistant || thermosensory behavior variant || cholinergic agonist resistant || hypoosmotic shock hypersensitive || DMPP response variant || selenium response variant || positive chemotaxis variant || nicotine resistant || chemical response variant || thermotaxis variant || benzaldehyde chemotaxis variant || chemosensory response variant || sodium chloride chemotaxis variant || chemical resistant || mechanosensation variant || AWC odorant chemotaxis variant |
| Papain-like | 0.5313 | INHERITED FROM: transgene expression variant || osmotic integrity variant || hypoosmotic shock hypersensitive || gene expression variant || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || organism metabolism processing variant || protein interaction variant |
| Calpain large subunit, middle domain (domain III) | 0.538 | INHERITED FROM: metabolic pathway variant || protein degradation variant || protein metabolism variant |
| Gastric lipase | 0.538 | INHERITED FROM: lipid metabolism variant || fat content variant |
| Myb/SANT domain | 0.538 | INHERITED FROM: growth rate variant |
| UBC-related | 0.581 | INHERITED FROM: transgene expression variant || transgene subcellular localization variant || gene expression variant || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || organism metabolism processing variant || protein interaction variant || late larval arrest |
| WW domain | 0.5834 | INHERITED FROM: maintenance of gene silencing variant |
| Class I alpha-1;2-mannosidase, catalytic domain | 0.5868 | INHERITED FROM: protein protein interaction variant || protein aggregation variant |
| Synaptotagmin-like (S variant) | 0.619 | INHERITED FROM: drug response variant || protein subcellular localization variant || acetylcholinesterase inhibitor resistant || acetylcholinesterase inhibitor response variant || pattern protein expression variant || drug resistant || chemical resistant |
| SH2 domain | 0.625 | INHERITED FROM: protein expression variant || protein expression reduced || level of protein expression variant |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.6657 | INHERITED FROM: transgene expression variant || gene expression variant || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || organism metabolism processing variant || protein interaction variant |
| Transforming growth factor (TGF)-beta | 0.7034 | INHERITED FROM: drug response variant || nicotine response variant || level of transgene expression variant || transgene expression reduced || levamisole response variant |
| Frizzled cysteine-rich domain | 0.7034 | INHERITED FROM: transgene expression reduced || antibody staining variant |
| EF-hand modules in multidomain proteins | 0.7034 | INHERITED FROM: protein expression variant || cell stress response variant |
| Ubiquitin-related | 0.7466 | INHERITED FROM: transgene expression variant || hypersensitive to protein aggregation induced paralysis || protein protein interaction variant || protein aggregation variant || protein interaction variant |
| H-NOX domain | 0.7688 | INHERITED FROM: drug response variant || carbon dioxide response variant || anesthetic response variant || carbon dioxide avoidance variant |
| Bacterial lipase | 0.7688 | INHERITED FROM: lipid metabolism variant || fat content variant |
| MIT domain | 0.7688 | INHERITED FROM: protein protein interaction variant || protein aggregation variant || protein interaction variant |
| Hemocyanin middle domain | 0.7688 | INHERITED FROM: germ cell ionizing radiation response variant || cell stress response variant || organism ionizing radiation response variant || cell ionizing radiation response variant |
| Cdc48 N-terminal domain-like | 0.7688 | INHERITED FROM: metabolic pathway variant || transgene expression reduced || protein protein interaction variant || protein aggregation variant || protein metabolism variant || protein interaction variant |
| Voltage-gated potassium channels | 0.7929 | INHERITED FROM: adrenergic receptor antagonist response variant || phentolamine resistant || growth rate variant || serotonin response variant || serotonin resistant || protein degradation variant |
| AAT-like | 0.8402 | INHERITED FROM: growth rate variant |
| LIM domain | 0.8402 | INHERITED FROM: protein expression reduced || level of protein expression variant || protein degradation variant |
| Cyclophilin (peptidylprolyl isomerase) | 0.8619 | INHERITED FROM: transgene expression variant || transgene subcellular localization variant || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || protein interaction variant |
| Glutathione S-transferase (GST), C-terminal domain | 0.8921 | INHERITED FROM: enzyme activity reduced || organism heat hypersensitive || enzyme activity variant || organism stress response variant || organism electrophilic stress hypersensitive || cadmium hypersensitive || metal response variant |
| Leucine zipper domain | 0.9005 | INHERITED FROM: mRNA levels reduced || level of transgene expression variant || pathogen susceptibility increased || pore forming toxin response variant || transgene expression reduced |
| Calmodulin-like | 0.9009 | INHERITED FROM: protein protein interaction variant || protein aggregation variant || protein interaction variant |
| Extended PAW domain | 0.911 | INHERITED FROM: transgene subcellular localization variant || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || protein interaction variant |
| SNF-like | 0.911 | INHERITED FROM: drug hypersensitive |
| Thioltransferase | 0.9357 | INHERITED FROM: protein aggregation induced behavior variant |
| Ribonuclease PH domain 2-like | 0.9464 | INHERITED FROM: early larval arrest |
| Ribonuclease PH domain 1-like | 0.9464 | INHERITED FROM: early larval arrest |
| NagD-like | 0.9464 | INHERITED FROM: dauer formation variant || dauer constitutive || dauer development variant |
| Choline/Carnitine O-acyltransferase | 0.9967 | INHERITED FROM: lipid metabolism variant || fat content variant || dauer development variant |
| Glutathione peroxidase-like | 1 | INHERITED FROM: paraquat hypersensitive || organism toxic chemical response variant || pesticide response variant || paraquat response variant |
| F-box domain | 1 | INHERITED FROM: resistant to protein aggregation induced paralysis || protein aggregation induced behavior variant |
| PAZ domain | 1 | INHERITED FROM: mRNA levels increased || RNAi enhanced || siRNA expression variant || 21U RNA expression variant || somatic transgene silencing variant || RNA expression variant || maintenance of gene silencing variant || RNAi response variant |
| Nuclear receptor | 1 | INHERITED FROM: dauer resistance to harsh conditions variant || SDS sensitive dauer || fat content increased || gene expression level reduced || transgene expression reduced || gene expression level high |
| N-acetyl transferase, NAT | 1 | INHERITED FROM: ectopic expression transgene |
| RING finger domain, C3HC4 | 1 | INHERITED FROM: transgene subcellular localization variant || germ cell ionizing radiation response variant || germ cell hypersensitive ionizing radiation || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || organism metabolism processing variant || protein interaction variant |
| B-box zinc-binding domain | 1 | INHERITED FROM: transgene expression variant || transgene subcellular localization variant || protein protein interaction variant || protein aggregation variant || protein interaction variant |
| Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: dauer resistance to harsh conditions variant || SDS sensitive dauer || fat content increased || gene expression level reduced || transgene expression reduced || gene expression level high |
| Rhodopsin-like | 1 | INHERITED FROM: locomotion rate serotonin variant || egg laying response to drug variant || drug withdrawal response variant || cyproheptadine resistant || serotonin induced pumping variant || serotonin response variant || serotonin resistant || male tail curling serotonin variant || organism pathogen response variant || serotonin hypersensitive || methiothepin resistant || biogenic amine receptor antagonist resistant || serotonin induced fat reduction variant || aqueous adaptation defective || mianserin resistant |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Chitinase insertion domain | 0 | Direct |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | Direct |
| Pyk2-associated protein beta ARF-GAP domain | 0 | Direct |
| GAPDH-like | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Ras-binding domain, RBD | 0 | Direct |
| Myeloperoxidase-like | 0 | Direct |
| POU-specific domain | 0 | Direct |
| Matrix metalloproteases, catalytic domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| PDI-like | 0 | Direct |
| D-aminoacid oxidase-like | 0 | Direct |
| Thiolase-related | 0 | Direct |
| Ran binding protein zinc finger-like | 0 | Direct |
| Amylase, catalytic domain | 0 | Direct |
| CAT-like | 0 | Direct |
| Reductases | 0 | Direct |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | Direct |
| alpha-mannosidase | 0 | Direct |
| BAR domain | 0 | Direct |
| Ubiquitin activating enzymes (UBA) | 0 | Direct |
| MIR domain | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| Dual specificity phosphatase-like | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| DPP6 catalytic domain-like | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| Nop domain | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| Internalin LRR domain | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| Class I glutamine amidotransferases (GAT) | 0 | Direct |
| Phosphotyrosine-binding domain (PTB) | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| Calcium ATPase, transmembrane domain M | 0 | Direct |
| a tRNA synthase domain | 0 | Direct |
| PEP carboxykinase C-terminal domain | 0 | Direct |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | Direct |
| Sir2 family of transcriptional regulators | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | Direct |
| La domain | 0 | Direct |
| t-snare proteins | 0 | Direct |
| Pancreatic carboxypeptidase, activation domain | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
| Type II chitinase | 0 | Direct |
| Annexin | 0 | Direct |
| Brix domain | 0 | Direct |
| Anticodon-binding domain | 0 | Direct |
| Citrate synthase | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| Cytoplasmic domain of inward rectifier potassium channel | 0 | Direct |
| Nucleosome core histones | 0 | Direct |
| Intermediate filament protein, coiled coil region | 0 | Direct |
| Heme-dependent catalases | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| Tim10/DDP | 0 | Direct |
| Pumilio repeat | 0 | Direct |
| Third domain of FERM | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Hydantoinase (dihydropyrimidinase) | 0 | Direct |
| RhoGDI-like | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| Acetyl-CoA synthetase-like | 0 | Direct |
| Spectrin repeat | 0 | Direct |
| WGR domain | 0 | Direct |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Regulator of G-protein signaling, RGS | 0 | Direct |
| SWIRM domain | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| PLC-like (P variant) | 0 | Direct |
| Retrovirus zinc finger-like domains | 0 | Direct |
| GABA-aminotransferase-like | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | Direct |
| First domain of FERM | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| FF domain | 0 | Direct |
| Cullin repeat | 0 | Direct |
| Ribokinase-like | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| CUT domain | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| Phosphoribosyltransferases (PRTases) | 0 | Direct |
| DPP6 N-terminal domain-like | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| ATP-dependent protease Lon (La), catalytic domain | 0 | Direct |
| Acylamino-acid-releasing enzyme, C-terminal donain | 0 | Direct |
| SMAD domain | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | Direct |
| Fatty acid binding protein-like | 0 | Direct |
| ARID domain | 0 | Direct |
| Tubulin, GTPase domain | 0 | Direct |
| Polo-box duplicated region | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | Direct |
| TBP-associated factors, TAFs | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | Direct |
| WWE domain | 0 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| Ribosomal protein L18 and S11 | 0 | Direct |
| BC C-terminal domain-like | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| 28-residue LRR | 0 | Direct |
| Glycosyl transferases group 1 | 0 | Direct |
| YWTD domain | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Ferredoxin reductase FAD-binding domain-like | 0 | Direct |
| L30e/L7ae ribosomal proteins | 0 | Direct |
| XPF/Rad1/Mus81 nuclease | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Sec63 N-terminal domain | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | Direct |
| ALDH-like | 0 | Direct |
| Carboxypeptidase regulatory domain | 0 | Direct |
| Fibrinogen C-terminal domain-like | 0 | Direct |
| Translation initiation factor eIF4e | 0 | Direct |
| Acyl-carrier protein (ACP) | 0 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | Direct |
| Cofilin-like | 0 | Direct |
| Myotubularin-like phosphatases | 0 | Direct |
| Insulin-like | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| COMT-like | 0 | Direct |
| SCF ubiquitin ligase complex WHB domain | 0 | Direct |
| Hexokinase | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| Poly(A) polymerase, PAP, middle domain | 0 | Direct |
| HSP20 | 0 | Direct |
| Proprotein convertase P-domain | 0 | Direct |
| PUA domain | 0 | Direct |
| U-box | 0 | Direct |
| Band 7/SPFH domain | 0 | Direct |
| Tetraspanin | 0 | Direct |
| Subtilases | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| Adenosine/AMP deaminase | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| Glycolipid transfer protein, GLTP | 0 | Direct |
| MutT-like | 0 | Direct |
| Methionine aminopeptidase, insert domain | 0 | Direct |
| Vertebrate phospholipase A2 | 0 | Direct |
| Clathrin adaptor core protein | 0 | Direct |
| acyl-CoA oxidase C-terminal domains | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| GAS2 domain | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | Direct |
| Clc chloride channel | 0 | Direct |
| Glycogenin | 0 | Direct |
| D-aminoacid oxidase, N-terminal domain | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | Direct |
| Reprolysin-like | 0 | Direct |
| NOL1/NOP2/sun | 0 | Direct |
| RNA-polymerase beta | 0 | Direct |
| DNA gyrase/MutL, N-terminal domain | 0 | Direct |
| Protein prenyltransferases | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| beta-Lactamase/D-ala carboxypeptidase | 0 | Direct |
| Eps15 homology domain (EH domain) | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| p120GAP domain-like | 0 | Direct |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | Direct |
| Calpain large subunit, catalytic domain (domain II) | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| Ngr ectodomain-like | 0 | Direct |
| Armadillo repeat | 0 | Direct |
| Proteasome subunits | 0 | Direct |
| GYF domain | 0 | Direct |
| Epoxide hydrolase | 0 | Direct |
| Acireductone dioxygenase | 0 | Direct |
| PhzC/PhzF-like | 0 | Direct |
| LysM domain | 0 | Direct |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | Direct |
| Cadherin | 0 | Direct |
| Single strand DNA-binding domain, SSB | 0 | Direct |
| MFPT repeat | 0 | Direct |
| Sec7 domain | 0 | Direct |
| PDZ domain | 0 | Direct |
| Acyl-CoA thioesterase | 0 | Direct |
| Linker histone H1/H5 | 0 | Direct |
| Pancreatic carboxypeptidases | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| Histone deacetylase, HDAC | 0 | Direct |
| Pepsin inhibitor-3 | 0 | Direct |
| Clathrin coat assembly domain | 0 | Direct |
| Erythroid transcription factor GATA-1 | 0 | Direct |
| Mammalian PLC | 0 | Direct |
| Paired domain | 0 | Direct |
| Chromo domain | 0 | Direct |
| Poly(ADP-ribose) polymerase, C-terminal domain | 0 | Direct |
| HEAT repeat | 0 | Direct |
| Laminin G-like module | 0 | Direct |
| LEM domain | 0 | Direct |
| DEP domain | 0 | Direct |
| acyl-CoA oxidase N-terminal domains | 0 | Direct |
| L-aminoacid/polyamine oxidase | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| Regulator of chromosome condensation RCC1 | 0 | Direct |
| cAMP-binding domain | 0 | Direct |
| NTF2-like | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| CoA transferase alpha subunit-like | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0 | Direct |
| 1,3-glucuronyltransferase | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| RNA-polymerase beta-prime | 0 | Direct |
| LacY-like proton/sugar symporter | 0 | Direct |
| DEATH domain, DD | 0 | Direct |
| YicI catalytic domain-like | 0 | Direct |
| Actin/HSP70 | 0 | Direct |
| Trunk domain of Sec23/24 | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Troponin I | 0 | Direct |
| Adenain-like | 0 | Direct |
| Inositol polyphosphate kinase (IPK) | 0 | Direct |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | Direct |
| Phosphatidylethanolamine binding protein | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain | 0 | Direct |
| CO dehydrogenase flavoprotein N-terminal domain-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| BC ATP-binding domain-like | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| IF2B-like | 0 | Direct |
| Sec63 C-terminal domain-like | 0 | Direct |
| Class I aldolase | 0 | Direct |
| VHS domain | 0 | Direct |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | Direct |
| AMPK-beta glycogen binding domain-like | 0 | Direct |
| Nucleoside diphosphate kinase, NDK | 0 | Direct |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | Direct |
| Class II glutamine amidotransferases | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | Direct |
| HAT/Suf repeat | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| NLI interacting factor-like phosphatase | 0 | Direct |
| YbiA-like | 0 | Direct |
| Phosphate binding protein-like | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| MIF4G domain-like | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Translational machinery components | 0 | Direct |
| Integrin domains | 0 | Direct |
| LDH N-terminal domain-like | 0 | Direct |
| BEACH domain | 0 | Direct |
| Sterol carrier protein, SCP | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| HCDH C-domain-like | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| PDEase | 0 | Direct |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0 | Direct |
| Choline kinase | 0 | Direct |
| Elafin-like | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| ets domain | 0 | Direct |
| Glycerol kinase | 0 | Direct |
| Glutaminase | 0 | Direct |
| Bactericidal permeability-increasing protein, BPI | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| Oxysterol-binding protein | 0 | Direct |
| Hedgehog C-terminal (Hog) autoprocessing domain | 0 | Direct |
| Arylsulfatase | 0 | Direct |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | Direct |
| YihX-like | 0 | Direct |
| Profilin (actin-binding protein) | 0 | Direct |
| 5' to 3' exonuclease catalytic domain | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| Hypothetical protein c14orf129, hspc210 | 0 | Direct |
| BC N-terminal domain-like | 0 | Direct |
| Glycerophosphoryl diester phosphodiesterase | 0 | Direct |
| Tubulin, C-terminal domain | 0 | Direct |
| SAM (sterile alpha motif) domain | 0 | Direct |
| alpha-mannosidase, domain 2 | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
| RecA protein-like (ATPase-domain) | 0 | Direct |
| Gamma-glutamyltranspeptidase-like | 0 | Direct |
| Skp1 dimerisation domain-like | 0 | Direct |
| CoA-binding domain | 0 | Direct |
| UBA domain | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| DNA gyrase/MutL, second domain | 0 | Direct |
| UDP-glucose pyrophosphorylase | 0 | Direct |
| Ribosomal protein S18 | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | Direct |
| FHA domain | 0 | Direct |
| Poly(A) polymerase, PAP, C-terminal domain | 0 | Direct |
| PaaI/YdiI-like | 0 | Direct |
| Filamin repeat (rod domain) | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| HD domain | 0 | Direct |
| SAND domain | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| NHL repeat | 0 | Direct |
| Pleckstrin-homology domain (PH domain) | 0 | Direct |
| beta 1,4 galactosyltransferase (b4GalT1) | 0 | Direct |
| Double-stranded RNA-binding domain (dsRBD) | 0 | Direct |
| alpha-catenin/vinculin | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| alpha-mannosidase, C-terminal domain | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| Poly(A) polymerase, PAP, N-terminal domain | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Arfaptin, Rac-binding fragment | 0 | Direct |
| Arginine methyltransferase | 0 | Direct |
| Tandem AAA-ATPase domain | 0.003654 | Inherited |
| ABC transporter ATPase domain-like | 0.01003 | Inherited |
| MSP-like | 0.02384 | Inherited |
| Homeodomain | 0.03701 | Inherited |
| ABC transporter transmembrane region | 0.04247 | Inherited |
| WD40-repeat | 0.04718 | Inherited |
| G proteins | 0.04739 | Inherited |
| L-arabinose binding protein-like | 0.05747 | Inherited |
| Protein kinases, catalytic subunit | 0.06104 | Inherited |
| SH3-domain | 0.07439 | Inherited |
| CCCH zinc finger | 0.08576 | Inherited |
| Canonical RBD | 0.1018 | Inherited |
| Extended AAA-ATPase domain | 0.1044 | Inherited |
| Tetratricopeptide repeat (TPR) | 0.1133 | Inherited |
| Cold shock DNA-binding domain-like | 0.1277 | Inherited |
| Adenylyl and guanylyl cyclase catalytic domain | 0.1328 | Inherited |
| Motor proteins | 0.1328 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.1328 | Inherited |
| Calcium ATPase, transduction domain A | 0.1719 | Inherited |
| Cyclin | 0.2094 | Inherited |
| DBL homology domain (DH-domain) | 0.2094 | Inherited |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.2094 | Inherited |
| Elongation factors | 0.2094 | Inherited |
| HMG-box | 0.2094 | Inherited |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.2094 | Inherited |
| Pepsin-like | 0.2306 | Inherited |
| Histone lysine methyltransferases | 0.2306 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.2539 | Inherited |
| Forkhead DNA-binding domain | 0.2539 | Inherited |
| DnaQ-like 3'-5' exonuclease | 0.2539 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.2651 | Inherited |
| Cytochrome P450 | 0.2724 | Inherited |
| Bromodomain | 0.2793 | Inherited |
| 6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.2793 | Inherited |
| Acetylcholinesterase-like | 0.2898 | Inherited |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.3079 | Inherited |
| Ankyrin repeat | 0.3262 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.3262 | Inherited |
| Meta-cation ATPase, catalytic domain P | 0.3387 | Inherited |
| Crotonase-like | 0.3387 | Inherited |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.3387 | Inherited |
| PX domain | 0.3729 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.4308 | Inherited |
| BTB/POZ domain | 0.4349 | Inherited |
| FKBP immunophilin/proline isomerase | 0.4485 | Inherited |
| Cation efflux protein transmembrane domain-like | 0.4485 | Inherited |
| PHD domain | 0.4587 | Inherited |
| Hect, E3 ligase catalytic domain | 0.4902 | Inherited |
| Myosin rod fragments | 0.4902 | Inherited |
| Pyridoxal-dependent decarboxylase | 0.4902 | Inherited |
| Glutathione S-transferase (GST), N-terminal domain | 0.4982 | Inherited |
| I set domains | 0.5198 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.5254 | Inherited |
| Papain-like | 0.5313 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.538 | Inherited |
| Gastric lipase | 0.538 | Inherited |
| Myb/SANT domain | 0.538 | Inherited |
| UBC-related | 0.581 | Inherited |
| WW domain | 0.5834 | Inherited |
| Class I alpha-1;2-mannosidase, catalytic domain | 0.5868 | Inherited |
| Synaptotagmin-like (S variant) | 0.619 | Inherited |
| SH2 domain | 0.625 | Inherited |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.6657 | Inherited |
| Transforming growth factor (TGF)-beta | 0.7034 | Inherited |
| Frizzled cysteine-rich domain | 0.7034 | Inherited |
| EF-hand modules in multidomain proteins | 0.7034 | Inherited |
| Ubiquitin-related | 0.7466 | Inherited |
| H-NOX domain | 0.7688 | Inherited |
| Bacterial lipase | 0.7688 | Inherited |
| MIT domain | 0.7688 | Inherited |
| Hemocyanin middle domain | 0.7688 | Inherited |
| Cdc48 N-terminal domain-like | 0.7688 | Inherited |
| Voltage-gated potassium channels | 0.7929 | Inherited |
| AAT-like | 0.8402 | Inherited |
| LIM domain | 0.8402 | Inherited |
| Cyclophilin (peptidylprolyl isomerase) | 0.8619 | Inherited |
| Glutathione S-transferase (GST), C-terminal domain | 0.8921 | Inherited |
| Leucine zipper domain | 0.9005 | Inherited |
| Calmodulin-like | 0.9009 | Inherited |
| Extended PAW domain | 0.911 | Inherited |
| SNF-like | 0.911 | Inherited |
| Thioltransferase | 0.9357 | Inherited |
| Ribonuclease PH domain 2-like | 0.9464 | Inherited |
| Ribonuclease PH domain 1-like | 0.9464 | Inherited |
| NagD-like | 0.9464 | Inherited |
| Choline/Carnitine O-acyltransferase | 0.9967 | Inherited |
| Glutathione peroxidase-like | 1 | Inherited |
| F-box domain | 1 | Inherited |
| PAZ domain | 1 | Inherited |
| Nuclear receptor | 1 | Inherited |
| N-acetyl transferase, NAT | 1 | Inherited |
| RING finger domain, C3HC4 | 1 | Inherited |
| B-box zinc-binding domain | 1 | Inherited |
| Nuclear receptor ligand-binding domain | 1 | Inherited |
| Rhodopsin-like | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Ribosomal protein L10-like | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Molybdenum cofactor biosynthesis proteins | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| ArfGap/RecO-like zinc finger | 0 | DIRECT |
| GroEL equatorial domain-like | 0 | DIRECT |
| Chromo domain-like | 0 | DIRECT |
| PEP carboxykinase-like | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| Hypothetical protein c14orf129, hspc210 | 0 | DIRECT |
| Ribosomal protein S18 | 0 | DIRECT |
| PAP/OAS1 substrate-binding domain | 0 | DIRECT |
| Elafin-like | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| Outer arm dynein light chain 1 | 0 | DIRECT |
| Clc chloride channel | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| PUA domain-like | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| NagB/RpiA/CoA transferase-like | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| lambda repressor-like DNA-binding domains | 0 | DIRECT |
| Ferritin-like | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| dsRNA-binding domain-like | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| Oxysterol-binding protein-like | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| Tubby C-terminal domain-like | 0 | DIRECT |
| Acetyl-CoA synthetase-like | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| Cystatin/monellin | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| ADP-ribosylation | 0 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| Nucleotidyltransferase | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| HSP20-like chaperones | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| Hedgehog/intein (Hint) domain | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| CAD & PB1 domains | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| ARID-like | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| t-snare proteins | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| GAT-like domain | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
| PIN domain-like | 0 | DIRECT |
| Insulin-like | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| Annexin | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | DIRECT |
| Profilin (actin-binding protein) | 0 | DIRECT |
| PEP carboxykinase N-terminal domain | 0 | DIRECT |
| R3H domain | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| CBD9-like | 0 | DIRECT |
| Galactose mutarotase-like | 0 | DIRECT |
| Diaminopimelate epimerase-like | 0 | DIRECT |
| YbiA-like | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| Glycolipid transfer protein, GLTP | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| Skp1 dimerisation domain-like | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| L30e-like | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Fibrinogen C-terminal domain-like | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| PYP-like sensor domain (PAS domain) | 0 | DIRECT |
| Ribosomal L27 protein-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| alpha/beta knot | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Carboxypeptidase regulatory domain-like | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| Sec63 N-terminal domain-like | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| Pepsin inhibitor-3 | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Cadherin-like | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| HCP-like | 0 | DIRECT |
| GroEL apical domain-like | 0 | DIRECT |
| Actin-like ATPase domain | 0 | DIRECT |
| VPS9 domain | 0 | DIRECT |
| ThrRS/AlaRS common domain | 0 | DIRECT |
| Retrovirus zinc finger-like domains | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| Intermediate filament protein, coiled coil region | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| MFPT repeat-like | 0 | DIRECT |
| Thiolase-like | 0 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Galactose oxidase, central domain | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| Carbohydrate phosphatase | 0 | DIRECT |
| PHM/PNGase F | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| Kringle-like | 0 | DIRECT |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| PK beta-barrel domain-like | 0 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
| Ran binding protein zinc finger-like | 0 | DIRECT |
| SCP-like | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| PreATP-grasp domain | 0 | DIRECT |
| GAS2 domain-like | 0 | DIRECT |
| Cullin repeat-like | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| Protease propeptides/inhibitors | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| ISP domain | 0 | DIRECT |
| Periplasmic binding protein-like II | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Band 7/SPFH domain | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| DEATH domain | 0 | DIRECT |
| eIF4e-like | 0 | DIRECT |
| Rap/Ran-GAP | 0 | DIRECT |
| Spectrin repeat | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| Carbon-nitrogen hydrolase | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Molybdenum cofactor-binding domain | 0 | DIRECT |
| ACP-like | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| cAMP-binding domain-like | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| SAND domain-like | 0 | DIRECT |
| ENTH/VHS domain | 0 | DIRECT |
| MgtE membrane domain-like | 0 | DIRECT |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | DIRECT |
| Pentein | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| TGS-like | 0 | DIRECT |
| Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
| Terpenoid synthases | 0 | DIRECT |
| HRDC-like | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| Chitinase insertion domain | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| CO dehydrogenase ISP C-domain like | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| Ribokinase-like | 0 | DIRECT |
| Citrate synthase | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| Invertebrate chitin-binding proteins | 0 | DIRECT |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Phoshotransferase/anion transport protein | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| Histone-fold | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| FAD-binding/transporter-associated domain-like | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| PEBP-like | 0 | DIRECT |
| Radical SAM enzymes | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
| WWE domain | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0.0000003335 | DIRECT |
| PH domain-like | 0.0000176 | DIRECT |
| PapD-like | 0.007762 | INHERITED FROM: lipid metabolism variant || dauer metabolism variant || fat content variant || larval arrest || dauer lifespan extended || dauer lifespan variant || slow growth || larval growth variant || developmental growth variant |
| PDZ domain-like | 0.007917 | INHERITED FROM: aldicarb response variant || drug resistant || protein expression variant || chemical resistant || acetylcholinesterase inhibitor response variant |
| TPR-like | 0.01127 | INHERITED FROM: ivermectin response variant || antihelmintic response variant || light body touch resistant || chemotaxis variant || positive chemotaxis defective || dauer development variant || ivermectin resistant |
| Periplasmic binding protein-like I | 0.01257 | INHERITED FROM: thermosensory behavior variant || benzaldehyde chemotaxis variant || memory retention defective || diacetyl chemotaxis variant || carbon dioxide response variant || organism temperature response variant || chemosensory response variant || thermotaxis variant || second messenger mediated signaling variant || carbon dioxide avoidance variant || organism environmental stimulus response variant || chemotaxis variant || aqueous chemosensory response variant || iodide chemotaxis defective || bromide chemotaxis defective || AWC odorant chemotaxis variant || AWC odorant chemotaxis defective || alkaline pH chemotaxis variant || lithium chemotaxis defective || magnesium chemotaxis defective || iodide chemotaxis variant || bromide chemotaxis variant || aqueous positive chemotaxis variant || mechanosensation variant |
| ABC transporter transmembrane region | 0.01777 | INHERITED FROM: colchicine hypersensitive || RNAi resistant || cadmium response variant || chemical hypersensitive || cadmium hypersensitive || RNAi response variant || chemical response variant || metal response variant |
| ARM repeat | 0.01833 | INHERITED FROM: gene expression variant || protein expression variant || sick || RNAi response variant || organism metabolism processing variant || sexually dimorphic physiology variant |
| Protein kinase-like (PK-like) | 0.03384 | INHERITED FROM: mid larval arrest || colchicine resistant || metabolic pathway variant || organism osmotic stress hypersensitive || lipid synthesis increased || aldicarb response variant || anoxia resistant || drug induced gene expression variant || protein subcellular localization variant || copper hypersensitive || second messenger mediated signaling variant || protein expression variant || organism environmental stimulus response variant || conflicting sensory integration variant || octanol chemotaxis defective || protein modification variant || aqueous chemosensory response variant || protein phosphorylation reduced || transgene expression reduced || alkaline pH chemotaxis variant || kinase activity reduced || dauer development variant || positive chemotaxis variant || chemical response variant || life span variant || hypoxia response variant || metal response variant || organism oxidative stress response variant || larval physiology variant || protein phosphorylation variant || mechanosensation variant || egg laying response to food variant |
| SH3-domain | 0.04295 | INHERITED FROM: aldicarb response variant || protein metabolism variant || protein expression variant || protein expression reduced || protein phosphorylation variant |
| Nucleic acid-binding proteins | 0.04295 | INHERITED FROM: avoids bacterial lawn || hermaphrodite physiology variant || hydroxyurea hypersensitive || organism environmental stimulus response variant || hydroxyurea response variant || sick || nonsense mRNA accumulation || mRNA surveillance defective || hypoxia resistant || sexually dimorphic physiology variant |
| Homeodomain-like | 0.04914 | INHERITED FROM: protein degradation variant || level of transgene expression variant || carbon dioxide response variant || carbon dioxide avoidance variant || adrenergic receptor antagonist response variant || ectopic expression transgene || growth rate variant || organism metabolism processing variant || imipramine resistant || egg laying imipramine resistant || phentolamine resistant |
| WD40 repeat-like | 0.05855 | INHERITED FROM: pathogen induced antimicrobial gene expression variant || aldicarb response variant || hermaphrodite physiology variant || protein aggregation variant || early larval arrest || protein aggregation induced behavior variant || protein protein interaction variant || osmotic avoidance variant || organism metabolism processing variant || late larval arrest || sexually dimorphic physiology variant |
| CCCH zinc finger | 0.06257 | INHERITED FROM: gene expression variant || transgene expression variant || mRNA expression ectopic || ectopic expression transgene |
| FYVE/PHD zinc finger | 0.0717 | INHERITED FROM: protein methylation variant || gene expression variant || organism UV hypersensitive || protein modification variant || organism UV response variant || organism metabolism processing variant |
| Translation proteins | 0.07824 | INHERITED FROM: proteasome core activity variant || hermaphrodite physiology variant || gene expression variant || transgene expression variant || protein aggregation variant || receptor mediated endocytosis defective || sick || protein protein interaction variant || protein phosphorylation increased || organism metabolism processing variant || mRNA levels increased || oocyte physiology variant || sexually dimorphic physiology variant || protein phosphorylation variant |
| "Winged helix" DNA-binding domain | 0.0889 | INHERITED FROM: anesthetic response variant || protein aggregation variant || protein aggregation induced behavior variant || spontaneous mutation rate increased || protein protein interaction variant || protein expression increased || germline transgene silencing variant || organism metabolism processing variant || life span variant |
| Nucleotide cyclase | 0.09226 | INHERITED FROM: cation positive chemotaxis defective || diacetyl chemotaxis variant || carbon dioxide response variant || anesthetic response variant || cation positive chemotaxis variant || chemosensory response variant || thermotaxis variant || second messenger mediated signaling variant || organism environmental stimulus response variant || chemotaxis variant || aqueous chemosensory response variant || iodide chemotaxis defective || bromide chemotaxis defective || AWC odorant chemotaxis variant || AWC odorant chemotaxis defective || alkaline pH chemotaxis variant || lithium chemotaxis defective || anion positive chemotaxis variant || osmotic avoidance variant || positive chemotaxis variant || magnesium chemotaxis defective || chemical response variant || iodide chemotaxis variant || bromide chemotaxis variant || anion positive chemotaxis defective |
| HLH, helix-loop-helix DNA-binding domain | 0.09226 | INHERITED FROM: lysine chemotaxis defective || pathogen resistance increased || fungal resistance increased || aqueous positive chemotaxis defective || ectopic expression transgene || organism metabolism processing variant || hypoxia response variant || gene expression level reduced || RNA expression variant |
| SMAD/FHA domain | 0.09799 | INHERITED FROM: aldicarb response variant || fat content reduced || dauer development variant |
| Calcium ATPase, transmembrane domain M | 0.1096 | INHERITED FROM: nicotine hypersensitive || lipid composition variant || drug hypersensitive |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1226 | INHERITED FROM: nicotine hypersensitive || lipid composition variant || drug hypersensitive |
| Regulator of G-protein signaling, RGS | 0.1226 | INHERITED FROM: negative chemotaxis variant || chemotaxis variant || mechanosensation variant |
| EGF/Laminin | 0.1279 | INHERITED FROM: octanol chemotaxis defective || octanol chemotaxis variant || odorant negative chemotaxis defective |
| Acid proteases | 0.1367 | INHERITED FROM: protein interaction variant || gene expression variant || transgene expression variant || protein aggregation variant || hypoosmotic shock hypersensitive || transgene subcellular localization variant || protein protein interaction variant || osmotic integrity variant || organism metabolism processing variant |
| Calcium ATPase, transduction domain A | 0.1367 | INHERITED FROM: nicotine hypersensitive || organism environmental stimulus response variant || drug hypersensitive |
| Cysteine-rich domain | 0.1451 | INHERITED FROM: pathogen induced gene expression variant || thermosensory behavior variant || pathogen induced antimicrobial gene expression variant || aldicarb response variant || odorant chemosensory response variant || drug induced gene expression variant || protein subcellular localization variant || gene expression variant || thermotaxis variant || antimicrobial gene expression variant || response to injury variant || bacterially unswollen || odorant positive chemotaxis variant || organism metabolism processing variant || organism stress response variant || positive chemotaxis variant || acetylcholinesterase inhibitor response variant |
| Quinoprotein alcohol dehydrogenase-like | 0.1529 | INHERITED FROM: protein degradation variant || mid larval arrest || oxygen response variant || L2 arrest || mRNA levels increased || hypoxia response variant |
| Multidrug efflux transporter AcrB transmembrane domain | 0.1585 | INHERITED FROM: odorant chemosensory response variant || egg integrity defective early emb || chemotaxis variant || positive chemotaxis defective || odorant positive chemotaxis defective || embryo osmotic integrity defective early emb |
| HMG-box | 0.1707 | INHERITED FROM: anesthetic response variant || maintenance of gene silencing variant || transgene expression variant |
| DBL homology domain (DH-domain) | 0.1707 | INHERITED FROM: aldicarb response variant || pathogen resistance increased || organism environmental stimulus response variant || bacterially unswollen || response to bacteria variant || organism pathogen response variant |
| ClpP/crotonase | 0.1707 | INHERITED FROM: lipid metabolism variant || level of transgene expression variant || fat content variant |
| Cytochrome P450 | 0.1734 | INHERITED FROM: cadmium response variant || metabolite content decreased || cadmium hypersensitive || metal response variant |
| (Trans)glycosidases | 0.1836 | INHERITED FROM: pathogen susceptibility increased |
| Ankyrin repeat | 0.199 | INHERITED FROM: chemosensory response variant || chemotaxis variant || octanol chemotaxis defective || organism heat response variant || octanol chemotaxis variant || odorant negative chemotaxis defective |
| Cyclin-like | 0.2234 | INHERITED FROM: level of transgene expression variant || protein phosphorylation reduced || protein phosphorylation variant |
| Cysteine proteinases | 0.2338 | INHERITED FROM: protein interaction variant || pattern of transgene expression variant || protein aggregation variant || hypoosmotic shock hypersensitive || protein protein interaction variant || osmotic integrity variant || organism metabolism processing variant || paraquat hypersensitive |
| Bromodomain | 0.2365 | INHERITED FROM: anesthetic resistant || anesthetic response variant || gene expression variant || organism UV hypersensitive || sick || ethanol resistant || organism UV response variant || drug adaptation variant || organism metabolism processing variant || acute functional tolerance to alcohol defective |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2365 | INHERITED FROM: lipid metabolism variant || fat content variant |
| Tudor/PWWP/MBT | 0.2365 | INHERITED FROM: pattern of transgene expression variant |
| POZ domain | 0.2544 | INHERITED FROM: early larval arrest || resistant to protein aggregation induced paralysis || protein aggregation induced behavior variant || L1 arrest |
| SNARE-like | 0.2638 | INHERITED FROM: aldicarb resistant || gene expression variant || pattern of transgene expression variant || transgene expression variant || acetylcholinesterase inhibitor resistant || sick || transgene subcellular localization variant || organism metabolism processing variant |
| Lipocalins | 0.264 | INHERITED FROM: lipid metabolism variant || fat content increased || fat content variant || paraquat hypersensitive |
| Metallo-dependent phosphatases | 0.2696 | INHERITED FROM: radiation induced germ cell apoptosis variant || germ cell resistant ionizing radiation |
| RNA-binding domain, RBD | 0.2851 | INHERITED FROM: RNA metabolism variant || pathogen induced antimicrobial gene expression variant || RNA processing variant || maintenance of gene silencing variant || alternative splicing variant || sick || organism metabolism processing variant || no induction of antimicrobial peptide expression after infection || innate immune response variant || starvation induced apoptosis variant || RNA expression variant || mRNA export variant |
| DNA/RNA polymerases | 0.294 | INHERITED FROM: organism UV hypersensitive || organism UV response variant || DNA metabolism variant |
| Translation proteins SH3-like domain | 0.3269 | INHERITED FROM: avoids bacterial lawn || gene expression variant || transgene expression variant || protein aggregation variant || early larval arrest || organism environmental stimulus response variant || protein protein interaction variant || response to bacteria variant || organism metabolism processing variant |
| Cation efflux protein transmembrane domain-like | 0.3269 | INHERITED FROM: manganese toxicity resistant || manganese response variant || cadmium hypersensitive || metal response variant |
| PX domain | 0.3269 | INHERITED FROM: protein subcellular localization variant || protein expression variant || protein expression reduced |
| HAD-like | 0.3502 | INHERITED FROM: nicotine hypersensitive |
| Nicotinic receptor ligand binding domain-like | 0.3658 | INHERITED FROM: thermosensory behavior variant || antihelmintic response variant || slowing response on food variant || cholinergic agonist resistant || benzaldehyde chemotaxis variant || DMPP resistant || chemosensory response variant || thermotaxis variant || organism environmental stimulus response variant || hypoosmotic shock hypersensitive || drug response variant || AWC odorant chemotaxis variant || selenium response variant || sodium chloride chemotaxis variant || DMPP response variant || chemical resistant || positive chemotaxis variant || chemical response variant || nicotine resistant || mechanosensation variant |
| PLP-dependent transferases | 0.3721 | INHERITED FROM: radiation induced germ cell apoptosis variant || germ cell resistant ionizing radiation |
| Ubiquitin-like | 0.3821 | INHERITED FROM: protein interaction variant || protein aggregation variant || heteroplasmy || protein protein interaction variant |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.402 | INHERITED FROM: thermosensory behavior variant || antihelmintic response variant || slowing response on food variant || cholinergic agonist resistant || benzaldehyde chemotaxis variant || DMPP resistant || chemosensory response variant || thermotaxis variant || organism environmental stimulus response variant || hypoosmotic shock hypersensitive || drug response variant || AWC odorant chemotaxis variant || selenium response variant || sodium chloride chemotaxis variant || DMPP response variant || chemical resistant || positive chemotaxis variant || chemical response variant || nicotine resistant || mechanosensation variant |
| FKBP-like | 0.4026 | INHERITED FROM: protein interaction variant || pattern of transgene expression variant || protein aggregation variant || transgene subcellular localization variant || protein protein interaction variant |
| HD-domain/PDEase-like | 0.4026 | INHERITED FROM: thermosensory behavior variant || organism temperature response variant || thermotaxis variant |
| RNI-like | 0.405 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| Class II aaRS and biotin synthetases | 0.4203 | INHERITED FROM: oxygen response variant || avoids bacterial lawn || hermaphrodite physiology variant || gene expression variant || transgene expression variant || organism environmental stimulus response variant || receptor mediated endocytosis defective || response to bacteria variant || organism metabolism processing variant || oocyte physiology variant || hypoxia response variant || hypoxia resistant || sexually dimorphic physiology variant |
| Hect, E3 ligase catalytic domain | 0.4474 | INHERITED FROM: protein interaction variant || gene expression variant || pattern of transgene expression variant || transgene expression variant || protein aggregation variant || cell ionizing radiation response variant || protein aggregation induced behavior variant || transgene subcellular localization variant || protein protein interaction variant || organism metabolism processing variant || germ cell ionizing radiation response variant |
| PRTase-like | 0.4474 | INHERITED FROM: Fluorouracil resistant || drug resistant |
| Myosin rod fragments | 0.4474 | INHERITED FROM: hermaphrodite physiology variant || drug resistant || sexually dimorphic physiology variant |
| DHS-like NAD/FAD-binding domain | 0.4474 | INHERITED FROM: metabolic pathway variant || protein expression variant || protein acetylation variant |
| Ribosomal protein S5 domain 2-like | 0.4806 | INHERITED FROM: early larval arrest |
| Galactose-binding domain-like | 0.4806 | INHERITED FROM: protein interaction variant || protein aggregation variant || protein protein interaction variant |
| Cystine-knot cytokines | 0.4836 | INHERITED FROM: nicotine response variant || levamisole response variant |
| Sm-like ribonucleoproteins | 0.4836 | INHERITED FROM: avoids bacterial lawn || hermaphrodite physiology variant || protein subcellular localization variant || pattern of transgene expression variant || transgene expression variant || receptor mediated endocytosis defective || sick || response to bacteria variant || organism heat response variant || life span variant || sexually dimorphic physiology variant || unfolded protein response variant |
| SH2 domain | 0.4928 | INHERITED FROM: level of protein expression variant || protein expression variant || protein expression reduced |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.4934 | INHERITED FROM: pattern protein expression variant |
| Zinc beta-ribbon | 0.4934 | INHERITED FROM: receptor mediated endocytosis defective |
| Calpain large subunit, middle domain (domain III) | 0.4934 | INHERITED FROM: protein degradation variant || metabolic pathway variant || protein metabolism variant |
| Riboflavin synthase domain-like | 0.4934 | INHERITED FROM: pattern protein expression variant |
| FAD/NAD(P)-binding domain | 0.5099 | INHERITED FROM: organism toxic chemical response variant || pesticide response variant || ATP levels variant || life span variant || ATP levels reduced || organism oxidative stress response variant |
| FAD-linked reductases, C-terminal domain | 0.52 | INHERITED FROM: life span variant |
| WW domain | 0.52 | INHERITED FROM: aldicarb resistant || maintenance of gene silencing variant || acetylcholinesterase inhibitor resistant |
| Voltage-gated potassium channels | 0.5279 | INHERITED FROM: protein degradation variant || serotonin resistant || positive chemotaxis defective || adrenergic receptor antagonist response variant || growth rate variant || serotonin response variant || imipramine resistant || phentolamine resistant || mechanosensation variant |
| SAM/Pointed domain | 0.5289 | INHERITED FROM: aldicarb response variant || gene expression level reduced |
| Nucleotidylyl transferase | 0.5289 | INHERITED FROM: oxygen response variant || avoids bacterial lawn || transgene expression increased || organism environmental stimulus response variant || response to bacteria variant || organism metabolism processing variant || hypoxia response variant || hypoxia resistant || paraquat resistant |
| SET domain | 0.5324 | INHERITED FROM: protein methylation variant || ectopic expression antibody || dosage compensation variant || protein metabolism variant || gene expression variant || maintenance of gene silencing variant || pattern of transgene expression variant || protein modification variant || RNAi response variant || spontaneous mutation rate increased || shortened life span || histone methylation variant || organism metabolism processing variant || life span variant |
| UBC-like | 0.5324 | INHERITED FROM: protein interaction variant || pattern of transgene expression variant || protein aggregation variant || sick || transgene subcellular localization variant || protein protein interaction variant || organism metabolism processing variant || late larval arrest |
| Seven-hairpin glycosidases | 0.5481 | INHERITED FROM: protein aggregation variant || protein protein interaction variant || extended life span |
| Multidrug resistance efflux transporter EmrE | 0.5551 | INHERITED FROM: pathogen resistance increased || bacterially unswollen || response to bacteria variant |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.5927 | INHERITED FROM: cellular osmotic stress response variant || organism osmotic stress response variant || pathogen induced antimicrobial gene expression variant || somatic sheath physiology variant || drug induced gene expression variant || protein subcellular localization variant || drug resistant || gonad sheath contractions variant || protein expression variant || organism environmental stimulus response variant || gonad sheath contraction rate reduced || response to injury variant || RNAi response variant || cell stress response variant || chemical resistant || growth rate variant || chemical response variant || egg laying serotonin variant || aging variant |
| Di-copper centre-containing domain | 0.6034 | INHERITED FROM: organism ionizing radiation response variant || cell ionizing radiation response variant || cell stress response variant || organism stress response variant || germ cell ionizing radiation response variant |
| KA1-like | 0.6034 | INHERITED FROM: RNA expression variant |
| Nucleotide-binding domain | 0.6034 | INHERITED FROM: extended life span |
| HIT/MYND zinc finger-like | 0.6318 | INHERITED FROM: pattern of transgene expression variant |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.641 | INHERITED FROM: gamma ray induced apoptosis increased || cell gamma ray response variant || organism gamma ray response variant |
| MFS general substrate transporter | 0.6418 | INHERITED FROM: organism high sodium chloride hypersensitive |
| 4Fe-4S ferredoxins | 0.6688 | INHERITED FROM: transgene expression increased || life span variant |
| Frizzled cysteine-rich domain | 0.6688 | INHERITED FROM: antibody staining variant || transgene expression reduced |
| S15/NS1 RNA-binding domain | 0.6688 | INHERITED FROM: avoids bacterial lawn || transgene expression increased || response to bacteria variant |
| DNase I-like | 0.6727 | INHERITED FROM: protein expression variant |
| GST C-terminal domain-like | 0.6824 | INHERITED FROM: enzyme activity reduced || organism electrophilic stress hypersensitive || organism environmental stimulus response variant || cadmium hypersensitive || enzyme activity variant || organism heat hypersensitive || organism stress response variant || metal response variant |
| MIT domain | 0.7394 | INHERITED FROM: protein interaction variant || protein aggregation variant || protein protein interaction variant |
| ADC-like | 0.7394 | INHERITED FROM: metabolic pathway variant || protein interaction variant || protein metabolism variant || protein aggregation variant || protein protein interaction variant || transgene expression reduced |
| Fibronectin type III | 0.7435 | INHERITED FROM: growth rate variant |
| alpha/beta-Hydrolases | 0.7453 | INHERITED FROM: acetylcholinesterase activity variant || acetylcholinesterase reduced |
| EF-hand | 0.7469 | INHERITED FROM: cellular osmotic stress response variant || aldicarb response variant || somatic sheath physiology variant || protein interaction variant || gonad sheath contractions variant || protein aggregation variant |
| Clavaminate synthase-like | 0.7957 | INHERITED FROM: protein methylation variant || histone methylation variant || life span variant |
| NAD kinase/diacylglycerol kinase-like | 0.7985 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
| Ribonuclease H-like | 0.7985 | INHERITED FROM: 21U RNA expression variant || maintenance of gene silencing variant || RNAi enhanced || RNAi response variant || somatic transgene silencing variant || siRNA expression variant || RNA expression variant |
| CoA-dependent acyltransferases | 0.8089 | INHERITED FROM: lipid metabolism variant || dauer development variant || organism metabolism processing variant |
| Cyclophilin-like | 0.8089 | INHERITED FROM: protein interaction variant || gene expression variant || pattern of transgene expression variant || transgene expression variant || protein aggregation variant || transgene subcellular localization variant || protein protein interaction variant |
| UBA-like | 0.8205 | INHERITED FROM: protein aggregation variant || protein protein interaction variant |
| SNF-like | 0.8404 | INHERITED FROM: drug hypersensitive |
| Leucine zipper domain | 0.8473 | INHERITED FROM: pore forming toxin response variant || level of transgene expression variant || mRNA levels reduced || mRNA expression variant || transgene expression reduced || pathogen susceptibility increased |
| Eukaryotic type KH-domain (KH-domain type I) | 0.8567 | INHERITED FROM: RNA expression variant |
| GTPase activation domain, GAP | 0.8567 | INHERITED FROM: protein expression variant |
| Thioredoxin-like | 0.8913 | INHERITED FROM: enzyme activity reduced || organism toxic chemical response variant || organism electrophilic stress hypersensitive || enzyme activity variant || organism heat hypersensitive || paraquat response variant || organism stress response variant || metal response variant |
| p53-like transcription factors | 0.8962 | INHERITED FROM: level of transgene expression variant || ectopic expression transgene || gene expression level reduced |
| Immunoglobulin | 0.9033 | INHERITED FROM: protein degradation variant || aldicarb response variant || growth rate variant |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.9054 | INHERITED FROM: level of transgene expression variant || fat content increased || dauer resistance to harsh conditions variant || transgene expression reduced || gene expression level high || SDS sensitive dauer || gene expression level reduced |
| Ribonuclease PH domain 2-like | 0.9222 | INHERITED FROM: early larval arrest |
| Nucleotide-diphospho-sugar transferases | 0.9267 | INHERITED FROM: resistant to lectin || lectin response variant |
| Saposin | 0.9491 | INHERITED FROM: level of transgene expression variant || increased pathogen survival || radiation induced germ cell apoptosis variant || pathogen load variant || transgene expression reduced || germ cell resistant ionizing radiation || germ cell ionizing radiation response variant |
| PAZ domain | 0.9843 | INHERITED FROM: 21U RNA expression variant || maintenance of gene silencing variant || RNAi enhanced || RNAi response variant || mRNA levels increased || somatic transgene silencing variant || siRNA expression variant || RNA expression variant |
| Ligand-binding domain in the NO signalling and Golgi transport | 0.9938 | INHERITED FROM: carbon dioxide response variant || anesthetic response variant || carbon dioxide avoidance variant || drug response variant || chemical response variant |
| RING/U-box | 1 | INHERITED FROM: germ cell hypersensitive ionizing radiation || organism ionizing radiation response variant || protein interaction variant || gene expression variant || pattern of transgene expression variant || protein aggregation variant || cell ionizing radiation response variant || transgene subcellular localization variant || protein protein interaction variant || cell stress response variant || organism metabolism processing variant || germ cell ionizing radiation response variant |
| Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: lipid metabolism variant || level of transgene expression variant || fat content increased || dauer resistance to harsh conditions variant || transgene expression reduced || gene expression level high || SDS sensitive dauer || gene expression level reduced |
| B-box zinc-binding domain | 1 | INHERITED FROM: protein interaction variant || gene expression variant || transgene expression variant || protein aggregation variant || transgene subcellular localization variant || protein protein interaction variant || organism metabolism processing variant |
| Bet v1-like | 1 | INHERITED FROM: growth rate variant |
| Snake toxin-like | 1 | INHERITED FROM: fat content reduced |
| F-box domain | 1 | INHERITED FROM: resistant to protein aggregation induced paralysis |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: male tail curling serotonin variant || serotonin induced fat reduction variant || locomotion rate serotonin variant || serotonin induced pumping variant |
| beta-beta-alpha zinc fingers | 1 | INHERITED FROM: egg laying serotonin resistant || organism metabolism processing variant || inhibitor of serotonin uptake variant || imipramine resistant || egg laying imipramine resistant |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Ribosomal protein L10-like | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Molybdenum cofactor biosynthesis proteins | 0 | Direct |
| Translational machinery components | 0 | Direct |
| ALDH-like | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| ArfGap/RecO-like zinc finger | 0 | Direct |
| GroEL equatorial domain-like | 0 | Direct |
| Chromo domain-like | 0 | Direct |
| PEP carboxykinase-like | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| SAICAR synthase-like | 0 | Direct |
| Hypothetical protein c14orf129, hspc210 | 0 | Direct |
| Ribosomal protein S18 | 0 | Direct |
| PAP/OAS1 substrate-binding domain | 0 | Direct |
| Elafin-like | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| Outer arm dynein light chain 1 | 0 | Direct |
| Clc chloride channel | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| PUA domain-like | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| NagB/RpiA/CoA transferase-like | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| lambda repressor-like DNA-binding domains | 0 | Direct |
| Ferritin-like | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| dsRNA-binding domain-like | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| Oxysterol-binding protein-like | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| Tubby C-terminal domain-like | 0 | Direct |
| Acetyl-CoA synthetase-like | 0 | Direct |
| Tim10-like | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| Cystatin/monellin | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| CO dehydrogenase molybdoprotein N-domain-like | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| ADP-ribosylation | 0 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| beta-lactamase/transpeptidase-like | 0 | Direct |
| Nucleotidyltransferase | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| HSP20-like chaperones | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| Hedgehog/intein (Hint) domain | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| CAD & PB1 domains | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| ARID-like | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| PGBD-like | 0 | Direct |
| t-snare proteins | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| YWTD domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| Integrin domains | 0 | Direct |
| GAT-like domain | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
| PIN domain-like | 0 | Direct |
| Insulin-like | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| Annexin | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| LEM domain | 0 | Direct |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | Direct |
| Profilin (actin-binding protein) | 0 | Direct |
| PEP carboxykinase N-terminal domain | 0 | Direct |
| R3H domain | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| LysM domain | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| CBD9-like | 0 | Direct |
| Galactose mutarotase-like | 0 | Direct |
| Diaminopimelate epimerase-like | 0 | Direct |
| YbiA-like | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| Glycolipid transfer protein, GLTP | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| Skp1 dimerisation domain-like | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| L30e-like | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Fibrinogen C-terminal domain-like | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| PYP-like sensor domain (PAS domain) | 0 | Direct |
| Ribosomal L27 protein-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
| alpha/beta knot | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Carboxypeptidase regulatory domain-like | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Aldolase | 0 | Direct |
| Tricorn protease domain 2 | 0 | Direct |
| Sec63 N-terminal domain-like | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| Pepsin inhibitor-3 | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Cadherin-like | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| HCP-like | 0 | Direct |
| GroEL apical domain-like | 0 | Direct |
| Actin-like ATPase domain | 0 | Direct |
| VPS9 domain | 0 | Direct |
| ThrRS/AlaRS common domain | 0 | Direct |
| Retrovirus zinc finger-like domains | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| Intermediate filament protein, coiled coil region | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| MFPT repeat-like | 0 | Direct |
| Thiolase-like | 0 | Direct |
| Tubulin nucleotide-binding domain-like | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Galactose oxidase, central domain | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| GroES-like | 0 | Direct |
| Polo-box domain | 0 | Direct |
| GroEL-intermediate domain like | 0 | Direct |
| Carbohydrate phosphatase | 0 | Direct |
| PHM/PNGase F | 0 | Direct |
| BEACH domain | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| FF domain | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| Kringle-like | 0 | Direct |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| PK beta-barrel domain-like | 0 | Direct |
| Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
| Ran binding protein zinc finger-like | 0 | Direct |
| SCP-like | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| PreATP-grasp domain | 0 | Direct |
| GAS2 domain-like | 0 | Direct |
| Cullin repeat-like | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| Nop domain | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| Protease propeptides/inhibitors | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| ISP domain | 0 | Direct |
| Periplasmic binding protein-like II | 0 | Direct |
| SIS domain | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Band 7/SPFH domain | 0 | Direct |
| LDH C-terminal domain-like | 0 | Direct |
| Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
| PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| Cytochrome c | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
| DEATH domain | 0 | Direct |
| eIF4e-like | 0 | Direct |
| Rap/Ran-GAP | 0 | Direct |
| Spectrin repeat | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| Carbon-nitrogen hydrolase | 0 | Direct |
| MIR domain | 0 | Direct |
| Molybdenum cofactor-binding domain | 0 | Direct |
| ACP-like | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| cAMP-binding domain-like | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| SAND domain-like | 0 | Direct |
| ENTH/VHS domain | 0 | Direct |
| MgtE membrane domain-like | 0 | Direct |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | Direct |
| Pentein | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| TGS-like | 0 | Direct |
| Families 57/38 glycoside transferase middle domain | 0 | Direct |
| Terpenoid synthases | 0 | Direct |
| HRDC-like | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Glutathione synthetase ATP-binding domain-like | 0 | Direct |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | Direct |
| Chitinase insertion domain | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| CO dehydrogenase ISP C-domain like | 0 | Direct |
| GYF domain | 0 | Direct |
| Composite domain of metallo-dependent hydrolases | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| Ribokinase-like | 0 | Direct |
| Citrate synthase | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| WGR domain-like | 0 | Direct |
| Invertebrate chitin-binding proteins | 0 | Direct |
| Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| FAD-linked oxidases, C-terminal domain | 0 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Phoshotransferase/anion transport protein | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| Histone-fold | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| FAD-binding/transporter-associated domain-like | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
| PEBP-like | 0 | Direct |
| Radical SAM enzymes | 0 | Direct |
| Sec7 domain | 0 | Direct |
| Nucleoside diphosphate kinase, NDK | 0 | Direct |
| WWE domain | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0.0000003335 | Direct |
| PH domain-like | 0.0000176 | Direct |
| PapD-like | 0.007762 | Inherited |
| PDZ domain-like | 0.007917 | Inherited |
| TPR-like | 0.01127 | Inherited |
| Periplasmic binding protein-like I | 0.01257 | Inherited |
| ABC transporter transmembrane region | 0.01777 | Inherited |
| ARM repeat | 0.01833 | Inherited |
| Protein kinase-like (PK-like) | 0.03384 | Inherited |
| SH3-domain | 0.04295 | Inherited |
| Nucleic acid-binding proteins | 0.04295 | Inherited |
| Homeodomain-like | 0.04914 | Inherited |
| WD40 repeat-like | 0.05855 | Inherited |
| CCCH zinc finger | 0.06257 | Inherited |
| FYVE/PHD zinc finger | 0.0717 | Inherited |
| Translation proteins | 0.07824 | Inherited |
| "Winged helix" DNA-binding domain | 0.0889 | Inherited |
| Nucleotide cyclase | 0.09226 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.09226 | Inherited |
| SMAD/FHA domain | 0.09799 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.1096 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1226 | Inherited |
| Regulator of G-protein signaling, RGS | 0.1226 | Inherited |
| EGF/Laminin | 0.1279 | Inherited |
| Acid proteases | 0.1367 | Inherited |
| Calcium ATPase, transduction domain A | 0.1367 | Inherited |
| Cysteine-rich domain | 0.1451 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.1529 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.1585 | Inherited |
| HMG-box | 0.1707 | Inherited |
| DBL homology domain (DH-domain) | 0.1707 | Inherited |
| ClpP/crotonase | 0.1707 | Inherited |
| Cytochrome P450 | 0.1734 | Inherited |
| (Trans)glycosidases | 0.1836 | Inherited |
| Ankyrin repeat | 0.199 | Inherited |
| Cyclin-like | 0.2234 | Inherited |
| Cysteine proteinases | 0.2338 | Inherited |
| Bromodomain | 0.2365 | Inherited |
| 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2365 | Inherited |
| Tudor/PWWP/MBT | 0.2365 | Inherited |
| POZ domain | 0.2544 | Inherited |
| SNARE-like | 0.2638 | Inherited |
| Lipocalins | 0.264 | Inherited |
| Metallo-dependent phosphatases | 0.2696 | Inherited |
| RNA-binding domain, RBD | 0.2851 | Inherited |
| DNA/RNA polymerases | 0.294 | Inherited |
| Translation proteins SH3-like domain | 0.3269 | Inherited |
| Cation efflux protein transmembrane domain-like | 0.3269 | Inherited |
| PX domain | 0.3269 | Inherited |
| HAD-like | 0.3502 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.3658 | Inherited |
| PLP-dependent transferases | 0.3721 | Inherited |
| Ubiquitin-like | 0.3821 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.402 | Inherited |
| FKBP-like | 0.4026 | Inherited |
| HD-domain/PDEase-like | 0.4026 | Inherited |
| RNI-like | 0.405 | Inherited |
| Class II aaRS and biotin synthetases | 0.4203 | Inherited |
| Hect, E3 ligase catalytic domain | 0.4474 | Inherited |
| PRTase-like | 0.4474 | Inherited |
| Myosin rod fragments | 0.4474 | Inherited |
| DHS-like NAD/FAD-binding domain | 0.4474 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.4806 | Inherited |
| Galactose-binding domain-like | 0.4806 | Inherited |
| Cystine-knot cytokines | 0.4836 | Inherited |
| Sm-like ribonucleoproteins | 0.4836 | Inherited |
| SH2 domain | 0.4928 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.4934 | Inherited |
| Zinc beta-ribbon | 0.4934 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.4934 | Inherited |
| Riboflavin synthase domain-like | 0.4934 | Inherited |
| FAD/NAD(P)-binding domain | 0.5099 | Inherited |
| FAD-linked reductases, C-terminal domain | 0.52 | Inherited |
| WW domain | 0.52 | Inherited |
| Voltage-gated potassium channels | 0.5279 | Inherited |
| SAM/Pointed domain | 0.5289 | Inherited |
| Nucleotidylyl transferase | 0.5289 | Inherited |
| SET domain | 0.5324 | Inherited |
| UBC-like | 0.5324 | Inherited |
| Seven-hairpin glycosidases | 0.5481 | Inherited |
| Multidrug resistance efflux transporter EmrE | 0.5551 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.5927 | Inherited |
| Di-copper centre-containing domain | 0.6034 | Inherited |
| KA1-like | 0.6034 | Inherited |
| Nucleotide-binding domain | 0.6034 | Inherited |
| HIT/MYND zinc finger-like | 0.6318 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.641 | Inherited |
| MFS general substrate transporter | 0.6418 | Inherited |
| 4Fe-4S ferredoxins | 0.6688 | Inherited |
| Frizzled cysteine-rich domain | 0.6688 | Inherited |
| S15/NS1 RNA-binding domain | 0.6688 | Inherited |
| DNase I-like | 0.6727 | Inherited |
| GST C-terminal domain-like | 0.6824 | Inherited |
| MIT domain | 0.7394 | Inherited |
| ADC-like | 0.7394 | Inherited |
| Fibronectin type III | 0.7435 | Inherited |
| alpha/beta-Hydrolases | 0.7453 | Inherited |
| EF-hand | 0.7469 | Inherited |
| Clavaminate synthase-like | 0.7957 | Inherited |
| NAD kinase/diacylglycerol kinase-like | 0.7985 | Inherited |
| Ribonuclease H-like | 0.7985 | Inherited |
| CoA-dependent acyltransferases | 0.8089 | Inherited |
| Cyclophilin-like | 0.8089 | Inherited |
| UBA-like | 0.8205 | Inherited |
| SNF-like | 0.8404 | Inherited |
| Leucine zipper domain | 0.8473 | Inherited |
| Eukaryotic type KH-domain (KH-domain type I) | 0.8567 | Inherited |
| GTPase activation domain, GAP | 0.8567 | Inherited |
| Thioredoxin-like | 0.8913 | Inherited |
| p53-like transcription factors | 0.8962 | Inherited |
| Immunoglobulin | 0.9033 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.9054 | Inherited |
| Ribonuclease PH domain 2-like | 0.9222 | Inherited |
| Nucleotide-diphospho-sugar transferases | 0.9267 | Inherited |
| Saposin | 0.9491 | Inherited |
| PAZ domain | 0.9843 | Inherited |
| Ligand-binding domain in the NO signalling and Golgi transport | 0.9938 | Inherited |
| RING/U-box | 1 | Inherited |
| Nuclear receptor ligand-binding domain | 1 | Inherited |
| B-box zinc-binding domain | 1 | Inherited |
| Bet v1-like | 1 | Inherited |
| Snake toxin-like | 1 | Inherited |
| F-box domain | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
| beta-beta-alpha zinc fingers | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
81631,55003
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
56176,55103
56176 - FAD-binding/transporter-associated domain-like
55103 - FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | DIRECT |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | DIRECT |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
51971,54373
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | DIRECT |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | DIRECT |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0 | DIRECT |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 0 | DIRECT |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | DIRECT |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | DIRECT |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | DIRECT |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | DIRECT |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0 | DIRECT |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
47741,56176
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | DIRECT |
54897,53187
54897 - Protease propeptides/inhibitors
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | DIRECT |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0 | DIRECT |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0 | DIRECT |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0 | DIRECT |
54495,46934
54495 - UBC-like
46934 - UBA-like | 0 | DIRECT |
54665,56003
54665 - CO dehydrogenase molybdoprotein N-domain-like
56003 - Molybdenum cofactor-binding domain | 0 | DIRECT |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 0 | DIRECT |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | DIRECT |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | DIRECT |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0 | DIRECT |
51338,51556
51338 - Composite domain of metallo-dependent hydrolases
51556 - Metallo-dependent hydrolases | 0 | DIRECT |
81383,50978
81383 - F-box domain
50978 - WD40 repeat-like | 0 | DIRECT |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | DIRECT |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | DIRECT |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
50978,50998
50978 - WD40 repeat-like
50998 - Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
56601,48403
56601 - beta-lactamase/transpeptidase-like
48403 - Ankyrin repeat | 0 | DIRECT |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | DIRECT |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
81324,81296
81324 - Voltage-gated potassium channels
81296 - E set domains | 0 | DIRECT |
52047,52047
52047 - RNI-like
52047 - RNI-like | 0 | DIRECT |
144232,82199
144232 - HIT/MYND zinc finger-like
82199 - SET domain | 0 | DIRECT |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0 | DIRECT |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | DIRECT |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | DIRECT |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
56112,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain | 0 | DIRECT |
81324,81327
81324 - Voltage-gated potassium channels
81327 - Small-conductance potassium channel | 0 | DIRECT |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
47576,47576
47576 - Calponin-homology domain, CH-domain
47576 - Calponin-homology domain, CH-domain | 0 | DIRECT |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | DIRECT |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | DIRECT |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | DIRECT |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
53187,49464
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | DIRECT |
74650,51445
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases | 0 | DIRECT |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | DIRECT |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
88713,88688
88713 - Glycoside hydrolase/deacetylase
88688 - Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | DIRECT |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
100950,100950
100950 - NagB/RpiA/CoA transferase-like
100950 - NagB/RpiA/CoA transferase-like | 0 | DIRECT |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | DIRECT |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | DIRECT |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | DIRECT |
55920,46785
55920 - Creatinase/aminopeptidase
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | DIRECT |
55326,56042
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | DIRECT |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | DIRECT |
141739,141739
141739 - MFPT repeat-like
141739 - MFPT repeat-like | 0 | DIRECT |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | DIRECT |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | DIRECT |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | DIRECT |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | DIRECT |
57889,48350
57889 - Cysteine-rich domain
48350 - GTPase activation domain, GAP | 0 | DIRECT |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0 | DIRECT |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | DIRECT |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | DIRECT |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | DIRECT |
51445,54556
51445 - (Trans)glycosidases
54556 - Chitinase insertion domain | 0 | DIRECT |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0 | DIRECT |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
161093,161093
161093 - MgtE membrane domain-like
161093 - MgtE membrane domain-like | 0 | DIRECT |
55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | DIRECT |
55394,55394
55394 - Bactericidal permeability-increasing protein, BPI
55394 - Bactericidal permeability-increasing protein, BPI | 0 | DIRECT |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | DIRECT |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0 | DIRECT |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | DIRECT |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
55729,55729
55729 - Acyl-CoA N-acyltransferases (Nat)
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | DIRECT |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | DIRECT |
56112,48371
56112 - Protein kinase-like (PK-like)
48371 - ARM repeat | 0 | DIRECT |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
52113,52113
52113 - BRCT domain
52113 - BRCT domain | 0 | DIRECT |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | DIRECT |
57903,82199
57903 - FYVE/PHD zinc finger
82199 - SET domain | 0 | DIRECT |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
52540,140990
52540 - P-loop containing nucleoside triphosphate hydrolases
140990 - FtsH protease domain-like | 0 | DIRECT |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | DIRECT |
57850,117839
57850 - RING/U-box
117839 - WWE domain | 0 | DIRECT |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
48403,52151
48403 - Ankyrin repeat
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
141673,50800
141673 - MOSC N-terminal domain-like
50800 - PK beta-barrel domain-like | 0 | DIRECT |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | DIRECT |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0 | DIRECT |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
48431,56968
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
56672,100879
56672 - DNA/RNA polymerases
100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
52540,81271
52540 - P-loop containing nucleoside triphosphate hydrolases
81271 - TGS-like | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0 | DIRECT |
64356,49447
64356 - SNARE-like
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0 | DIRECT |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | DIRECT |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
54292,47741
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like | 0 | DIRECT |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01777 | INHERITED FROM: colchicine hypersensitive || RNAi resistant || cadmium response variant || chemical hypersensitive || cadmium hypersensitive || RNAi response variant || chemical response variant || metal response variant |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.09799 | INHERITED FROM: ivermectin response variant || antihelmintic response variant || aldicarb response variant || organism temperature response variant || gene expression variant || dauer defective || pattern of transgene expression variant || chemotaxis variant || aqueous chemosensory response variant || positive chemotaxis defective || ivermectin resistant |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1169 | INHERITED FROM: organism environmental stimulus response variant || sick || organism UV response variant || organism stress response variant |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.1226 | INHERITED FROM: nicotine hypersensitive || lipid composition variant || drug hypersensitive |
56112,55073
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0.1226 | INHERITED FROM: cation positive chemotaxis defective || benzaldehyde chemotaxis variant || cation positive chemotaxis variant || chemosensory response variant || chemotaxis variant || aqueous chemosensory response variant || iodide chemotaxis defective || bromide chemotaxis defective || AWC odorant chemotaxis variant || AWC odorant chemotaxis defective || alkaline pH chemotaxis variant || lithium chemotaxis defective || anion positive chemotaxis variant || positive chemotaxis variant || magnesium chemotaxis defective || chemical response variant || iodide chemotaxis variant || bromide chemotaxis variant || anion positive chemotaxis defective |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.1336 | INHERITED FROM: cadmium response variant || cadmium hypersensitive |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.1904 | INHERITED FROM: proteasome core activity variant || mRNA levels reduced || transgene expression variant || protein aggregation variant || protein protein interaction variant || protein phosphorylation increased || mRNA levels increased || protein phosphorylation variant |
56436,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.2234 | INHERITED FROM: cadmium response variant || cadmium hypersensitive |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.2365 | INHERITED FROM: nicotine hypersensitive || organism environmental stimulus response variant || drug hypersensitive |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2365 | INHERITED FROM: lipid metabolism variant || fat content variant |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.294 | INHERITED FROM: ivermectin response variant || odorant chemosensory response variant || drug resistant || pesticide response variant || dauer defective || negative chemotaxis variant || chemotaxis variant || aqueous positive chemotaxis defective || aqueous chemosensory response variant || positive chemotaxis defective || dauer development variant || chemical resistant || osmotic avoidance variant || ivermectin resistant || positive chemotaxis variant || dauer formation variant || aqueous positive chemotaxis variant || mechanosensation variant |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.294 | INHERITED FROM: protein interaction variant || pattern of transgene expression variant || protein aggregation variant || protein protein interaction variant |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.3269 | INHERITED FROM: aldicarb response variant || drug response variant || acetylcholinesterase inhibitor response variant |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.3903 | INHERITED FROM: organism starvation response variant || gene expression variant || organism metabolism processing variant || late larval arrest || starvation induced apoptosis variant |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.402 | INHERITED FROM: thermosensory behavior variant || antihelmintic response variant || slowing response on food variant || cholinergic agonist resistant || benzaldehyde chemotaxis variant || DMPP resistant || chemosensory response variant || thermotaxis variant || organism environmental stimulus response variant || hypoosmotic shock hypersensitive || drug response variant || AWC odorant chemotaxis variant || selenium response variant || sodium chloride chemotaxis variant || DMPP response variant || chemical resistant || positive chemotaxis variant || chemical response variant || nicotine resistant || mechanosensation variant |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.4527 | INHERITED FROM: protein expression variant || organism metabolism processing variant || protein expression reduced |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.5125 | INHERITED FROM: enzyme activity reduced || organism electrophilic stress hypersensitive || organism environmental stimulus response variant || cadmium hypersensitive || enzyme activity variant || organism heat hypersensitive || paraquat response variant || organism stress response variant || metal response variant |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.5481 | INHERITED FROM: hermaphrodite physiology variant || sexually dimorphic physiology variant |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0.5481 | INHERITED FROM: 21U RNA expression variant || gene expression variant || maintenance of gene silencing variant || RNAi response variant || RNA expression variant |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.5481 | INHERITED FROM: protein expression reduced |
51045,51045
51045 - WW domain
51045 - WW domain | 0.6034 | INHERITED FROM: transgene expression variant |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.6688 | INHERITED FROM: organism UV hypersensitive || organism UV response variant || organism stress response variant |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0.6688 | INHERITED FROM: avoids bacterial lawn || transgene expression increased || response to bacteria variant |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.6727 | INHERITED FROM: shortened life span || life span variant |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.6884 | INHERITED FROM: protein expression reduced |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.7394 | INHERITED FROM: level of protein expression variant || protein expression variant || protein expression reduced |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.7786 | INHERITED FROM: dauer resistance to harsh conditions variant || SDS sensitive dauer |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.8089 | INHERITED FROM: protein degradation variant || growth rate variant |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.8454 | INHERITED FROM: protein degradation variant || growth rate variant |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0.9222 | INHERITED FROM: early larval arrest |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.9265 | INHERITED FROM: drug resistant || chemical resistant |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.9511 | INHERITED FROM: lipid metabolism variant || fat content variant || dauer development variant |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0.9511 | INHERITED FROM: protein interaction variant || protein aggregation variant || protein protein interaction variant |
53300,56436
53300 - vWA-like
56436 - C-type lectin-like | 1 | INHERITED FROM: pathogen induced death increased || pathogen susceptibility increased |
57850,57850
57850 - RING/U-box
57850 - RING/U-box | 1 | INHERITED FROM: protein interaction variant || protein aggregation variant || transgene subcellular localization variant || protein protein interaction variant |
57850,57845
57850 - RING/U-box
57845 - B-box zinc-binding domain | 1 | INHERITED FROM: protein interaction variant || protein aggregation variant || transgene subcellular localization variant || protein protein interaction variant |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
81631,55003
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
56176,55103
56176 - FAD-binding/transporter-associated domain-like
55103 - FAD-linked oxidases, C-terminal domain | 0 | Direct |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
51735,55347
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0 | Direct |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | Direct |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | Direct |
51971,54373
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | Direct |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | Direct |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0 | Direct |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 0 | Direct |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | Direct |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | Direct |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | Direct |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | Direct |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0 | Direct |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | Direct |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | Direct |
47741,56176
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | Direct |
54897,53187
54897 - Protease propeptides/inhibitors
53187 - Zn-dependent exopeptidases | 0 | Direct |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | Direct |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0 | Direct |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0 | Direct |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0 | Direct |
54495,46934
54495 - UBC-like
46934 - UBA-like | 0 | Direct |
54665,56003
54665 - CO dehydrogenase molybdoprotein N-domain-like
56003 - Molybdenum cofactor-binding domain | 0 | Direct |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 0 | Direct |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | Direct |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | Direct |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0 | Direct |
51338,51556
51338 - Composite domain of metallo-dependent hydrolases
51556 - Metallo-dependent hydrolases | 0 | Direct |
81383,50978
81383 - F-box domain
50978 - WD40 repeat-like | 0 | Direct |
51905,56425
51905 - FAD/NAD(P)-binding domain
56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 0 | Direct |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | Direct |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
52440,56059
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like | 0 | Direct |
50978,50998
50978 - WD40 repeat-like
50998 - Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
56601,48403
56601 - beta-lactamase/transpeptidase-like
48403 - Ankyrin repeat | 0 | Direct |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | Direct |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
81324,81296
81324 - Voltage-gated potassium channels
81296 - E set domains | 0 | Direct |
52047,52047
52047 - RNI-like
52047 - RNI-like | 0 | Direct |
144232,82199
144232 - HIT/MYND zinc finger-like
82199 - SET domain | 0 | Direct |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0 | Direct |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
68923,53795
68923 - PEP carboxykinase N-terminal domain
53795 - PEP carboxykinase-like | 0 | Direct |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | Direct |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
56112,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain | 0 | Direct |
81324,81327
81324 - Voltage-gated potassium channels
81327 - Small-conductance potassium channel | 0 | Direct |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
47576,47576
47576 - Calponin-homology domain, CH-domain
47576 - Calponin-homology domain, CH-domain | 0 | Direct |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | Direct |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | Direct |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | Direct |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
53187,49464
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | Direct |
74650,51445
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases | 0 | Direct |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | Direct |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
88713,88688
88713 - Glycoside hydrolase/deacetylase
88688 - Families 57/38 glycoside transferase middle domain | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | Direct |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
100950,100950
100950 - NagB/RpiA/CoA transferase-like
100950 - NagB/RpiA/CoA transferase-like | 0 | Direct |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | Direct |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | Direct |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0 | Direct |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | Direct |
55920,46785
55920 - Creatinase/aminopeptidase
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | Direct |
55326,56042
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | Direct |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | Direct |
141739,141739
141739 - MFPT repeat-like
141739 - MFPT repeat-like | 0 | Direct |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | Direct |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | Direct |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | Direct |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | Direct |
57889,48350
57889 - Cysteine-rich domain
48350 - GTPase activation domain, GAP | 0 | Direct |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0 | Direct |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | Direct |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0 | Direct |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | Direct |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | Direct |
51445,54556
51445 - (Trans)glycosidases
54556 - Chitinase insertion domain | 0 | Direct |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0 | Direct |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | Direct |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
161093,161093
161093 - MgtE membrane domain-like
161093 - MgtE membrane domain-like | 0 | Direct |
55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | Direct |
55394,55394
55394 - Bactericidal permeability-increasing protein, BPI
55394 - Bactericidal permeability-increasing protein, BPI | 0 | Direct |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | Direct |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0 | Direct |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | Direct |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
55729,55729
55729 - Acyl-CoA N-acyltransferases (Nat)
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | Direct |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | Direct |
56112,48371
56112 - Protein kinase-like (PK-like)
48371 - ARM repeat | 0 | Direct |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
52113,52113
52113 - BRCT domain
52113 - BRCT domain | 0 | Direct |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | Direct |
57903,82199
57903 - FYVE/PHD zinc finger
82199 - SET domain | 0 | Direct |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
52540,140990
52540 - P-loop containing nucleoside triphosphate hydrolases
140990 - FtsH protease domain-like | 0 | Direct |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | Direct |
57850,117839
57850 - RING/U-box
117839 - WWE domain | 0 | Direct |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
48403,52151
48403 - Ankyrin repeat
52151 - FabD/lysophospholipase-like | 0 | Direct |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
48179,48179
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
141673,50800
141673 - MOSC N-terminal domain-like
50800 - PK beta-barrel domain-like | 0 | Direct |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | Direct |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0 | Direct |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | Direct |
48431,56968
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
56672,100879
56672 - DNA/RNA polymerases
100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | Direct |
52540,81271
52540 - P-loop containing nucleoside triphosphate hydrolases
81271 - TGS-like | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0 | Direct |
64356,49447
64356 - SNARE-like
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0 | Direct |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0 | Direct |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | Direct |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
54292,47741
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like | 0 | Direct |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01777 | Inherited |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.09799 | Inherited |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1169 | Inherited |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.1226 | Inherited |
56112,55073
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0.1226 | Inherited |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.1336 | Inherited |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.1904 | Inherited |
56436,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.2234 | Inherited |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.2365 | Inherited |
51735,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.2365 | Inherited |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.294 | Inherited |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.294 | Inherited |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.3269 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.3903 | Inherited |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.402 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.4527 | Inherited |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.5125 | Inherited |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.5481 | Inherited |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0.5481 | Inherited |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.5481 | Inherited |
51045,51045
51045 - WW domain
51045 - WW domain | 0.6034 | Inherited |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.6688 | Inherited |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0.6688 | Inherited |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0.6727 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.6884 | Inherited |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.7394 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.7786 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.8089 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.8454 | Inherited |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0.9222 | Inherited |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.9265 | Inherited |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.9511 | Inherited |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0.9511 | Inherited |
53300,56436
53300 - vWA-like
56436 - C-type lectin-like | 1 | Inherited |
57850,57850
57850 - RING/U-box
57850 - RING/U-box | 1 | Inherited |
57850,57845
57850 - RING/U-box
57845 - B-box zinc-binding domain | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56436,49854,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0 | DIRECT |
81301,81631,55003
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | DIRECT |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
74650,51445,51011
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | DIRECT |
46938,52087,101576
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain
101576 - Supernatant protein factor (SPF), C-terminal domain | 0 | DIRECT |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | DIRECT |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | DIRECT |
57414,57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
57625,57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | DIRECT |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0 | DIRECT |
57362,57362,57362
57362 - BPTI-like
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | DIRECT |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
55973,55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | DIRECT |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | DIRECT |
54292,47741,56176
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | DIRECT |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
56112,82615,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain
82615 - Polo-box domain | 0 | DIRECT |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
56968,48431,56968
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
57567,57567,57567
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors | 0 | DIRECT |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
50044,50044,50044
50044 - SH3-domain
50044 - SH3-domain
50044 - SH3-domain | 0 | DIRECT |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.1367 | INHERITED FROM: nicotine hypersensitive || lipid composition variant || drug hypersensitive |
56436,56436,49854
56436 - C-type lectin-like
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.3631 | INHERITED FROM: cadmium response variant || cadmium hypersensitive |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.3638 | INHERITED FROM: protein interaction variant || pattern of transgene expression variant || protein aggregation variant || protein protein interaction variant |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.3638 | INHERITED FROM: protein expression reduced |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.4474 | INHERITED FROM: protein degradation variant || level of protein expression variant || protein expression variant || organism metabolism processing variant || protein expression reduced |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0.8416 | INHERITED FROM: protein interaction variant || pattern of transgene expression variant || protein aggregation variant || transgene subcellular localization variant || protein protein interaction variant |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.9491 | INHERITED FROM: protein degradation variant || growth rate variant |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.9938 | INHERITED FROM: protein degradation variant || growth rate variant |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56436,49854,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51735,48179,48179
51735 - NAD(P)-binding Rossmann-fold domains
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0 | Direct |
81301,81631,55003
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain | 0 | Direct |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
74650,51445,51011
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | Direct |
46938,52087,101576
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain
101576 - Supernatant protein factor (SPF), C-terminal domain | 0 | Direct |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | Direct |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | Direct |
57414,57414,57414
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like
57414 - Hairpin loop containing domain-like | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
57625,57625,57625
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins
57625 - Invertebrate chitin-binding proteins | 0 | Direct |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0 | Direct |
57362,57362,57362
57362 - BPTI-like
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0 | Direct |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
55973,55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | Direct |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | Direct |
54292,47741,56176
54292 - 2Fe-2S ferredoxin-like
47741 - CO dehydrogenase ISP C-domain like
56176 - FAD-binding/transporter-associated domain-like | 0 | Direct |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
56112,82615,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain
82615 - Polo-box domain | 0 | Direct |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
56968,48431,56968
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
57567,57567,57567
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors
57567 - Serine protease inhibitors | 0 | Direct |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | Direct |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
50044,50044,50044
50044 - SH3-domain
50044 - SH3-domain
50044 - SH3-domain | 0 | Direct |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.1367 | Inherited |
56436,56436,49854
56436 - C-type lectin-like
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.3631 | Inherited |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.3638 | Inherited |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.3638 | Inherited |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.4474 | Inherited |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0.8416 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.9491 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.9938 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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