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Worm Phenotype (WP): drug response variant
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0.0000000481 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.0000000481 | DIRECT |
| G proteins | 0.0002069 | DIRECT |
| H-NOX domain | 0.0002078 | DIRECT |
| Eps15 homology domain (EH domain) | 0.0002078 | DIRECT |
| Calcium ATPase, transmembrane domain M | 0.0002899 | DIRECT |
| Spectrin repeat | 0.0002899 | DIRECT |
| Transforming growth factor (TGF)-beta | 0.0009062 | DIRECT |
| Synaptotagmin-like (S variant) | 0.00094 | DIRECT |
| PDZ domain | 0.001421 | INHERITED FROM: egg laying serotonin variant || aldicarb response variant |
| Phosphoribosyltransferases (PRTases) | 0.004988 | INHERITED FROM: drug resistant || Fluorouracil resistant |
| Clathrin coat assembly domain | 0.004988 | INHERITED FROM: aldicarb resistant || acetylcholinesterase inhibitor response variant || drug resistant || aldicarb response variant || acetylcholinesterase inhibitor resistant |
| WD40-repeat | 0.009702 | INHERITED FROM: ivermectin response variant || ivermectin resistant |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0.01112 | INHERITED FROM: drug hypersensitive |
| I set domains | 0.0184 | INHERITED FROM: aldicarb response variant |
| SNF-like | 0.02112 | INHERITED FROM: drug hypersensitive |
| Protein kinases, catalytic subunit | 0.04624 | INHERITED FROM: colchicine resistant || aldicarb response variant |
| Meta-cation ATPase, catalytic domain P | 0.04799 | INHERITED FROM: nicotine response variant || nicotine hypersensitive |
| Tubulin, GTPase domain | 0.07678 | INHERITED FROM: nicotine response variant |
| Tubulin, C-terminal domain | 0.07678 | INHERITED FROM: nicotine response variant |
| SH3-domain | 0.1036 | INHERITED FROM: aldicarb response variant |
| Pleckstrin-homology domain (PH domain) | 0.1036 | INHERITED FROM: egg laying serotonin variant || aldicarb response variant || egg laying imipramine resistant |
| Calcium ATPase, transduction domain A | 0.1118 | INHERITED FROM: drug hypersensitive || nicotine hypersensitive |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1118 | INHERITED FROM: drug hypersensitive || nicotine hypersensitive |
| Pyridoxal-dependent decarboxylase | 0.1223 | INHERITED FROM: carbon dioxide response variant || egg laying response to drug variant || carbon dioxide avoidance variant |
| cAMP-binding domain | 0.1624 | INHERITED FROM: carbon dioxide response variant || carbon dioxide avoidance variant |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.1624 | INHERITED FROM: drug resistant || aldicarb response variant |
| Homeodomain | 0.1765 | INHERITED FROM: carbon dioxide response variant || anesthetic response variant || carbon dioxide avoidance variant |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.1946 | INHERITED FROM: drug hypersensitive || hydroxyurea hypersensitive || hydroxyurea response variant |
| t-snare proteins | 0.1946 | INHERITED FROM: drug hypersensitive |
| Bromodomain | 0.1946 | INHERITED FROM: acute functional tolerance to alcohol defective || anesthetic resistant || anesthetic response variant || drug adaptation variant || ethanol resistant |
| Transducin (heterotrimeric G protein), gamma chain | 0.1946 | INHERITED FROM: anesthetic response variant |
| HMG-box | 0.1946 | INHERITED FROM: anesthetic response variant |
| Rhodopsin-like | 0.2281 | INHERITED FROM: locomotion rate serotonin variant || serotonin induced pumping variant || serotonin hypersensitive || biogenic amine receptor antagonist resistant || egg laying response to drug variant || serotonin response variant || methiothepin resistant || serotonin resistant || serotonin induced fat reduction variant || drug withdrawal response variant || cyproheptadine resistant || mianserin resistant || male tail curling serotonin variant |
| DBL homology domain (DH-domain) | 0.2326 | INHERITED FROM: aldicarb response variant |
| Voltage-gated potassium channels | 0.2415 | INHERITED FROM: serotonin response variant || adrenergic receptor antagonist response variant || phentolamine resistant || serotonin resistant |
| Leucine zipper domain | 0.3268 | INHERITED FROM: pore forming toxin response variant |
| PLC-like (P variant) | 0.4238 | INHERITED FROM: aldicarb response variant |
| ABC transporter transmembrane region | 0.9591 | INHERITED FROM: colchicine hypersensitive |
| Adenylyl and guanylyl cyclase catalytic domain | 0.9814 | INHERITED FROM: carbon dioxide response variant || anesthetic response variant |
| ABC transporter ATPase domain-like | 1 | INHERITED FROM: colchicine hypersensitive |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
| Nicotinic receptor ligand binding domain-like | 0.0000000481 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.0000000481 | Direct |
| G proteins | 0.0002069 | Direct |
| H-NOX domain | 0.0002078 | Direct |
| Eps15 homology domain (EH domain) | 0.0002078 | Direct |
| Calcium ATPase, transmembrane domain M | 0.0002899 | Direct |
| Spectrin repeat | 0.0002899 | Direct |
| Transforming growth factor (TGF)-beta | 0.0009062 | Direct |
| Synaptotagmin-like (S variant) | 0.00094 | Direct |
| PDZ domain | 0.001421 | Inherited |
| Phosphoribosyltransferases (PRTases) | 0.004988 | Inherited |
| Clathrin coat assembly domain | 0.004988 | Inherited |
| WD40-repeat | 0.009702 | Inherited |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0.01112 | Inherited |
| I set domains | 0.0184 | Inherited |
| SNF-like | 0.02112 | Inherited |
| Protein kinases, catalytic subunit | 0.04624 | Inherited |
| Meta-cation ATPase, catalytic domain P | 0.04799 | Inherited |
| Tubulin, GTPase domain | 0.07678 | Inherited |
| Tubulin, C-terminal domain | 0.07678 | Inherited |
| SH3-domain | 0.1036 | Inherited |
| Pleckstrin-homology domain (PH domain) | 0.1036 | Inherited |
| Calcium ATPase, transduction domain A | 0.1118 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1118 | Inherited |
| Pyridoxal-dependent decarboxylase | 0.1223 | Inherited |
| cAMP-binding domain | 0.1624 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.1624 | Inherited |
| Homeodomain | 0.1765 | Inherited |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.1946 | Inherited |
| t-snare proteins | 0.1946 | Inherited |
| Bromodomain | 0.1946 | Inherited |
| Transducin (heterotrimeric G protein), gamma chain | 0.1946 | Inherited |
| HMG-box | 0.1946 | Inherited |
| Rhodopsin-like | 0.2281 | Inherited |
| DBL homology domain (DH-domain) | 0.2326 | Inherited |
| Voltage-gated potassium channels | 0.2415 | Inherited |
| Leucine zipper domain | 0.3268 | Inherited |
| PLC-like (P variant) | 0.4238 | Inherited |
| ABC transporter transmembrane region | 0.9591 | Inherited |
| Adenylyl and guanylyl cyclase catalytic domain | 0.9814 | Inherited |
| ABC transporter ATPase domain-like | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Download Newick format tree:
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
(show details)
Supra-domains annotated to this WP term (SPWP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.00000002762 | DIRECT |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0.0001031 | DIRECT |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0.0001485 | DIRECT |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.0001485 | DIRECT |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.0003768 | DIRECT |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.0007304 | DIRECT |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.00512 | INHERITED FROM: drug resistant |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.02794 | INHERITED FROM: drug hypersensitive || nicotine hypersensitive |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.03129 | INHERITED FROM: aldicarb response variant || ivermectin response variant || ivermectin resistant |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.07363 | INHERITED FROM: nicotine response variant |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.1054 | INHERITED FROM: drug hypersensitive || nicotine hypersensitive |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.1187 | INHERITED FROM: drug resistant || ivermectin response variant || ivermectin resistant |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.3167 | INHERITED FROM: aldicarb response variant |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.9894 | INHERITED FROM: colchicine hypersensitive |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.00000002762 | Direct |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0.0001031 | Direct |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0.0001485 | Direct |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.0001485 | Direct |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.0003768 | Direct |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.0007304 | Direct |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.00512 | Inherited |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.02794 | Inherited |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.03129 | Inherited |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.07363 | Inherited |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.1054 | Inherited |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.1187 | Inherited |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.3167 | Inherited |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.9894 | Inherited |
(show details)
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
|
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
