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Worm Phenotype (WP): gene expression variant
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| GroEL equatorial domain-like | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Histone-fold | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| ISP domain | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| GroEL apical domain-like | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0 | DIRECT |
| Chromo domain-like | 0.0000000003088 | DIRECT |
| FYVE/PHD zinc finger | 0.0000000157 | DIRECT |
| SET domain | 0.0000001156 | DIRECT |
| RING/U-box | 0.000003572 | DIRECT |
| Acid proteases | 0.000003616 | DIRECT |
| Class II aaRS and biotin synthetases | 0.000003616 | DIRECT |
| Cysteine-rich domain | 0.000004141 | DIRECT |
| SNARE-like | 0.000009201 | DIRECT |
| PAP/OAS1 substrate-binding domain | 0.00001716 | DIRECT |
| Translation proteins | 0.00001827 | DIRECT |
| Bromodomain | 0.00004687 | DIRECT |
| Translation proteins SH3-like domain | 0.0000765 | DIRECT |
| Arginase/deacetylase | 0.00009084 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00009084 | DIRECT |
| Cullin repeat-like | 0.00009084 | DIRECT |
| Hect, E3 ligase catalytic domain | 0.00009084 | DIRECT |
| CCCH zinc finger | 0.000108 | DIRECT |
| B-box zinc-binding domain | 0.0002035 | DIRECT |
| ARM repeat | 0.000212 | DIRECT |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.0002303 | DIRECT |
| Retrovirus zinc finger-like domains | 0.0004275 | DIRECT |
| Cyclophilin-like | 0.0004898 | DIRECT |
| ACP-like | 0.0008423 | DIRECT |
| Sm-like ribonucleoproteins | 0.001202 | INHERITED FROM: protein subcellular localization variant || transgene expression variant || pattern of transgene expression variant |
| RNA-binding domain, RBD | 0.001274 | INHERITED FROM: RNA processing variant || mRNA export variant || no induction of antimicrobial peptide expression after infection || alternative splicing variant || pathogen induced antimicrobial gene expression variant || RNA expression variant |
| "Winged helix" DNA-binding domain | 0.001274 | INHERITED FROM: protein expression increased |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.001648 | INHERITED FROM: transgene subcellular localization variant || transgene expression variant |
| L30e-like | 0.001648 | INHERITED FROM: RNA processing variant || mRNA surveillance defective || pattern of transgene expression variant |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.002209 | INHERITED FROM: transgene expression increased || level of transgene expression variant || protein expression reduced |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.002521 | INHERITED FROM: level of transgene expression variant |
| Tudor/PWWP/MBT | 0.002672 | INHERITED FROM: pattern of transgene expression variant |
| Riboflavin synthase domain-like | 0.004408 | INHERITED FROM: pattern protein expression variant |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.004408 | INHERITED FROM: pattern protein expression variant |
| PAZ domain | 0.005399 | INHERITED FROM: siRNA expression variant || 21U RNA expression variant || RNA expression variant || mRNA levels increased |
| FKBP-like | 0.005477 | INHERITED FROM: transgene subcellular localization variant || pattern of transgene expression variant |
| P-loop containing nucleoside triphosphate hydrolases | 0.005795 | INHERITED FROM: pattern of transgene expression variant |
| 4Fe-4S ferredoxins | 0.007446 | INHERITED FROM: transgene expression increased |
| Frizzled cysteine-rich domain | 0.007446 | INHERITED FROM: antibody staining variant || transgene expression reduced |
| Leucine zipper domain | 0.007976 | INHERITED FROM: level of transgene expression variant || mRNA expression variant || transgene expression reduced || mRNA levels reduced |
| Cyclin-like | 0.009852 | INHERITED FROM: protein phosphorylation reduced || protein phosphorylation variant |
| Zn-binding ribosomal proteins | 0.01148 | INHERITED FROM: RNA processing variant || mRNA surveillance defective || level of transgene expression variant |
| dsRNA-binding domain-like | 0.01218 | INHERITED FROM: RNA expression variant |
| DHS-like NAD/FAD-binding domain | 0.01317 | INHERITED FROM: protein acetylation variant |
| Single hybrid motif | 0.01347 | INHERITED FROM: transgene expression increased || level of transgene expression variant |
| Saposin | 0.02037 | INHERITED FROM: level of transgene expression variant || transgene expression reduced |
| ADC-like | 0.02161 | INHERITED FROM: transgene expression reduced |
| Cdc48 domain 2-like | 0.02161 | INHERITED FROM: transgene expression reduced |
| Integrin domains | 0.02161 | INHERITED FROM: protein expression variant || level of protein expression variant || protein expression reduced |
| HIT/MYND zinc finger-like | 0.02482 | INHERITED FROM: pattern of transgene expression variant |
| p53-like transcription factors | 0.02593 | INHERITED FROM: ectopic expression transgene || gene expression level reduced |
| PH domain-like | 0.02618 | INHERITED FROM: protein expression variant || drug induced gene expression variant || level of protein expression variant || protein phosphorylation variant |
| PX domain | 0.02745 | INHERITED FROM: protein subcellular localization variant || protein expression variant || protein expression reduced |
| Homeodomain-like | 0.0317 | INHERITED FROM: level of transgene expression variant || ectopic expression transgene |
| SH3-domain | 0.03197 | INHERITED FROM: protein expression variant || protein phosphorylation variant || protein expression reduced |
| UBC-like | 0.03648 | INHERITED FROM: transgene subcellular localization variant || pattern of transgene expression variant |
| Chaperone J-domain | 0.04743 | INHERITED FROM: transgene expression variant || pattern of transgene expression variant |
| Actin-like ATPase domain | 0.04743 | INHERITED FROM: transgene expression variant || protein expression reduced |
| HLH, helix-loop-helix DNA-binding domain | 0.05402 | INHERITED FROM: ectopic expression transgene || gene expression level reduced || RNA expression variant |
| PDZ domain-like | 0.06917 | INHERITED FROM: protein expression variant |
| ARID-like | 0.0712 | INHERITED FROM: protein expression variant |
| Tubby C-terminal domain-like | 0.0712 | INHERITED FROM: transgene expression reduced |
| S15/NS1 RNA-binding domain | 0.0712 | INHERITED FROM: transgene expression increased |
| CAD & PB1 domains | 0.0712 | INHERITED FROM: protein expression variant |
| Protein kinase-like (PK-like) | 0.07575 | INHERITED FROM: protein subcellular localization variant || protein expression variant || drug induced gene expression variant || protein phosphorylation reduced || transgene expression reduced || protein phosphorylation variant || protein modification variant |
| Quinoprotein alcohol dehydrogenase-like | 0.08343 | INHERITED FROM: mRNA levels increased |
| Nucleic acid-binding proteins | 0.08688 | INHERITED FROM: mRNA surveillance defective |
| HSP20-like chaperones | 0.09065 | INHERITED FROM: transgene subcellular localization variant |
| SAM/Pointed domain | 0.1439 | INHERITED FROM: gene expression level reduced |
| KA1-like | 0.1456 | INHERITED FROM: RNA expression variant |
| Cysteine proteinases | 0.1508 | INHERITED FROM: pattern of transgene expression variant |
| GTPase activation domain, GAP | 0.1917 | INHERITED FROM: protein expression variant |
| Nucleotidyltransferase | 0.2195 | INHERITED FROM: miRNA expression variant || RNA expression variant |
| Eukaryotic type KH-domain (KH-domain type I) | 0.2479 | INHERITED FROM: RNA expression variant |
| Transducin (alpha subunit), insertion domain | 0.2479 | INHERITED FROM: drug induced gene expression variant || protein phosphorylation reduced || protein phosphorylation variant |
| HMG-box | 0.2479 | INHERITED FROM: transgene expression variant |
| WD40 repeat-like | 0.2609 | INHERITED FROM: pathogen induced antimicrobial gene expression variant |
| SH2 domain | 0.2778 | INHERITED FROM: protein expression variant || level of protein expression variant || protein expression reduced |
| Second domain of FERM | 0.3916 | INHERITED FROM: level of protein expression variant || protein expression reduced |
| Nucleotidylyl transferase | 0.4104 | INHERITED FROM: transgene expression increased |
| Intermediate filament protein, coiled coil region | 0.4502 | INHERITED FROM: antibody staining variant || protein expression variant |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.4532 | INHERITED FROM: level of transgene expression variant || gene expression level high || gene expression level reduced || transgene expression reduced |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.4942 | INHERITED FROM: protein subcellular localization variant || pathogen induced antimicrobial gene expression variant || protein expression variant || drug induced gene expression variant |
| Spectrin repeat | 0.5042 | INHERITED FROM: antibody staining variant || level of protein expression variant |
| Activating enzymes of the ubiquitin-like proteins | 0.5042 | INHERITED FROM: protein subcellular localization variant || transgene subcellular localization variant || pattern of transgene expression variant |
| PYP-like sensor domain (PAS domain) | 0.5042 | INHERITED FROM: gene expression level reduced || transgene expression reduced |
| Lamin A/C globular tail domain | 0.5042 | INHERITED FROM: antibody staining variant || protein expression variant |
| Ribonuclease H-like | 0.5967 | INHERITED FROM: siRNA expression variant || 21U RNA expression variant || RNA expression variant |
| Clavaminate synthase-like | 0.6951 | INHERITED FROM: histone methylation variant || protein methylation variant |
| Nuclear receptor ligand-binding domain | 0.9407 | INHERITED FROM: level of transgene expression variant || gene expression level high || gene expression level reduced || transgene expression reduced |
| ClpP/crotonase | 1 | INHERITED FROM: level of transgene expression variant |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| FF domain | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| Cytochrome c | 0 | Direct |
| GroEL-intermediate domain like | 0 | Direct |
| GroEL equatorial domain-like | 0 | Direct |
| MIR domain | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Histone-fold | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| ISP domain | 0 | Direct |
| Nop domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| GroEL apical domain-like | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Tubulin nucleotide-binding domain-like | 0 | Direct |
| Chromo domain-like | 0.0000000003088 | Direct |
| FYVE/PHD zinc finger | 0.0000000157 | Direct |
| SET domain | 0.0000001156 | Direct |
| RING/U-box | 0.000003572 | Direct |
| Acid proteases | 0.000003616 | Direct |
| Class II aaRS and biotin synthetases | 0.000003616 | Direct |
| Cysteine-rich domain | 0.000004141 | Direct |
| SNARE-like | 0.000009201 | Direct |
| PAP/OAS1 substrate-binding domain | 0.00001716 | Direct |
| Translation proteins | 0.00001827 | Direct |
| Bromodomain | 0.00004687 | Direct |
| Translation proteins SH3-like domain | 0.0000765 | Direct |
| Arginase/deacetylase | 0.00009084 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00009084 | Direct |
| Cullin repeat-like | 0.00009084 | Direct |
| Hect, E3 ligase catalytic domain | 0.00009084 | Direct |
| CCCH zinc finger | 0.000108 | Direct |
| B-box zinc-binding domain | 0.0002035 | Direct |
| ARM repeat | 0.000212 | Direct |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.0002303 | Direct |
| Retrovirus zinc finger-like domains | 0.0004275 | Direct |
| Cyclophilin-like | 0.0004898 | Direct |
| ACP-like | 0.0008423 | Direct |
| Sm-like ribonucleoproteins | 0.001202 | Inherited |
| RNA-binding domain, RBD | 0.001274 | Inherited |
| "Winged helix" DNA-binding domain | 0.001274 | Inherited |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.001648 | Inherited |
| L30e-like | 0.001648 | Inherited |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.002209 | Inherited |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.002521 | Inherited |
| Tudor/PWWP/MBT | 0.002672 | Inherited |
| Riboflavin synthase domain-like | 0.004408 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.004408 | Inherited |
| PAZ domain | 0.005399 | Inherited |
| FKBP-like | 0.005477 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 0.005795 | Inherited |
| 4Fe-4S ferredoxins | 0.007446 | Inherited |
| Frizzled cysteine-rich domain | 0.007446 | Inherited |
| Leucine zipper domain | 0.007976 | Inherited |
| Cyclin-like | 0.009852 | Inherited |
| Zn-binding ribosomal proteins | 0.01148 | Inherited |
| dsRNA-binding domain-like | 0.01218 | Inherited |
| DHS-like NAD/FAD-binding domain | 0.01317 | Inherited |
| Single hybrid motif | 0.01347 | Inherited |
| Saposin | 0.02037 | Inherited |
| ADC-like | 0.02161 | Inherited |
| Cdc48 domain 2-like | 0.02161 | Inherited |
| Integrin domains | 0.02161 | Inherited |
| HIT/MYND zinc finger-like | 0.02482 | Inherited |
| p53-like transcription factors | 0.02593 | Inherited |
| PH domain-like | 0.02618 | Inherited |
| PX domain | 0.02745 | Inherited |
| Homeodomain-like | 0.0317 | Inherited |
| SH3-domain | 0.03197 | Inherited |
| UBC-like | 0.03648 | Inherited |
| Chaperone J-domain | 0.04743 | Inherited |
| Actin-like ATPase domain | 0.04743 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.05402 | Inherited |
| PDZ domain-like | 0.06917 | Inherited |
| ARID-like | 0.0712 | Inherited |
| Tubby C-terminal domain-like | 0.0712 | Inherited |
| S15/NS1 RNA-binding domain | 0.0712 | Inherited |
| CAD & PB1 domains | 0.0712 | Inherited |
| Protein kinase-like (PK-like) | 0.07575 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.08343 | Inherited |
| Nucleic acid-binding proteins | 0.08688 | Inherited |
| HSP20-like chaperones | 0.09065 | Inherited |
| SAM/Pointed domain | 0.1439 | Inherited |
| KA1-like | 0.1456 | Inherited |
| Cysteine proteinases | 0.1508 | Inherited |
| GTPase activation domain, GAP | 0.1917 | Inherited |
| Nucleotidyltransferase | 0.2195 | Inherited |
| Eukaryotic type KH-domain (KH-domain type I) | 0.2479 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.2479 | Inherited |
| HMG-box | 0.2479 | Inherited |
| WD40 repeat-like | 0.2609 | Inherited |
| SH2 domain | 0.2778 | Inherited |
| Second domain of FERM | 0.3916 | Inherited |
| Nucleotidylyl transferase | 0.4104 | Inherited |
| Intermediate filament protein, coiled coil region | 0.4502 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.4532 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.4942 | Inherited |
| Spectrin repeat | 0.5042 | Inherited |
| Activating enzymes of the ubiquitin-like proteins | 0.5042 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.5042 | Inherited |
| Lamin A/C globular tail domain | 0.5042 | Inherited |
| Ribonuclease H-like | 0.5967 | Inherited |
| Clavaminate synthase-like | 0.6951 | Inherited |
| Nuclear receptor ligand-binding domain | 0.9407 | Inherited |
| ClpP/crotonase | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| POU-specific domain | 0 | DIRECT |
| PDI-like | 0 | DIRECT |
| CAT-like | 0 | DIRECT |
| RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| a tRNA synthase domain | 0 | DIRECT |
| Sir2 family of transcriptional regulators | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
| Brix domain | 0 | DIRECT |
| Heme-dependent catalases | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| Tubulin, GTPase domain | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| L30e/L7ae ribosomal proteins | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Acyl-carrier protein (ACP) | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| SCF ubiquitin ligase complex WHB domain | 0 | DIRECT |
| HSP20 | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| Clathrin adaptor core protein | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | DIRECT |
| RNA-polymerase beta | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| p120GAP domain-like | 0 | DIRECT |
| Proteasome subunits | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| Histone deacetylase, HDAC | 0 | DIRECT |
| Clathrin coat assembly domain | 0 | DIRECT |
| Erythroid transcription factor GATA-1 | 0 | DIRECT |
| Mammalian PLC | 0 | DIRECT |
| Chromo domain | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Trunk domain of Sec23/24 | 0 | DIRECT |
| Adenain-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| MIF4G domain-like | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| ets domain | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| Tubulin, C-terminal domain | 0 | DIRECT |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
| RecA protein-like (ATPase-domain) | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Nucleosome core histones | 0.000000000000003129 | DIRECT |
| Actin/HSP70 | 0.000000004572 | DIRECT |
| UBC-related | 0.00000008393 | DIRECT |
| Forkhead DNA-binding domain | 0.000000307 | DIRECT |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.0000013 | DIRECT |
| PHD domain | 0.000001336 | DIRECT |
| Dual specificity phosphatase-like | 0.000003282 | DIRECT |
| Pepsin-like | 0.000003282 | DIRECT |
| Histone lysine methyltransferases | 0.00004426 | DIRECT |
| Papain-like | 0.00005275 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.00006882 | DIRECT |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.0001677 | DIRECT |
| Bromodomain | 0.0002415 | DIRECT |
| Hect, E3 ligase catalytic domain | 0.0002854 | DIRECT |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.0003044 | DIRECT |
| Armadillo repeat | 0.0003073 | DIRECT |
| SMAD domain | 0.0007469 | DIRECT |
| Translational machinery components | 0.0007469 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0007469 | DIRECT |
| CCCH zinc finger | 0.0009152 | DIRECT |
| B-box zinc-binding domain | 0.001056 | INHERITED FROM: transgene subcellular localization variant || transgene expression variant |
| Cyclophilin (peptidylprolyl isomerase) | 0.002184 | INHERITED FROM: transgene subcellular localization variant || transgene expression variant || pattern of transgene expression variant |
| TBP-associated factors, TAFs | 0.002801 | INHERITED FROM: transgene expression variant |
| Cold shock DNA-binding domain-like | 0.003045 | INHERITED FROM: mRNA surveillance defective |
| Canonical RBD | 0.004154 | INHERITED FROM: RNA processing variant || mRNA export variant || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant || RNA expression variant |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.004183 | INHERITED FROM: transgene subcellular localization variant |
| PDZ domain | 0.00568 | INHERITED FROM: protein expression variant |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.007675 | INHERITED FROM: protein subcellular localization variant || pattern protein expression variant || pattern of transgene expression variant |
| Extended PAW domain | 0.008803 | INHERITED FROM: transgene subcellular localization variant || pattern of transgene expression variant |
| Ubiquitin activating enzymes (UBA) | 0.0129 | INHERITED FROM: transgene subcellular localization variant |
| Transforming growth factor (TGF)-beta | 0.0129 | INHERITED FROM: level of transgene expression variant || transgene expression reduced |
| Frizzled cysteine-rich domain | 0.0129 | INHERITED FROM: antibody staining variant || transgene expression reduced |
| EF-hand modules in multidomain proteins | 0.0129 | INHERITED FROM: protein expression variant |
| Pumilio repeat | 0.01318 | INHERITED FROM: protein subcellular localization variant || protein expression ectopic |
| FKBP immunophilin/proline isomerase | 0.01318 | INHERITED FROM: transgene subcellular localization variant || pattern of transgene expression variant |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.01318 | INHERITED FROM: transgene expression increased || level of transgene expression variant || protein expression reduced |
| Cyclin | 0.01836 | INHERITED FROM: level of transgene expression variant |
| Elongation factors | 0.01836 | INHERITED FROM: protein phosphorylation increased || protein phosphorylation variant || mRNA levels reduced || mRNA levels increased |
| Homeodomain | 0.01914 | INHERITED FROM: level of transgene expression variant || ectopic expression transgene |
| RING finger domain, C3HC4 | 0.02256 | INHERITED FROM: transgene subcellular localization variant || pattern of transgene expression variant |
| PAZ domain | 0.027 | INHERITED FROM: siRNA expression variant || 21U RNA expression variant || RNA expression variant || mRNA levels increased |
| Leucine zipper domain | 0.02978 | INHERITED FROM: level of transgene expression variant || transgene expression reduced || mRNA levels reduced |
| Biotinyl/lipoyl-carrier proteins and domains | 0.03099 | INHERITED FROM: transgene expression increased || level of transgene expression variant |
| Cdc48 domain 2-like | 0.03294 | INHERITED FROM: transgene expression reduced |
| Anticodon-binding domain | 0.03294 | INHERITED FROM: transgene expression increased |
| Biotin dependent carboxylase carboxyltransferase domain | 0.03294 | INHERITED FROM: transgene expression increased |
| Cdc48 N-terminal domain-like | 0.03294 | INHERITED FROM: transgene expression reduced |
| Chaperone J-domain | 0.04377 | INHERITED FROM: transgene expression variant || pattern of transgene expression variant |
| HLH, helix-loop-helix DNA-binding domain | 0.0499 | INHERITED FROM: ectopic expression transgene || gene expression level reduced || RNA expression variant |
| PX domain | 0.0599 | INHERITED FROM: protein subcellular localization variant || protein expression variant |
| SH3-domain | 0.07594 | INHERITED FROM: protein expression variant || protein expression reduced |
| DEP domain | 0.1049 | INHERITED FROM: transgene expression reduced |
| WD40-repeat | 0.1098 | INHERITED FROM: pathogen induced antimicrobial gene expression variant |
| Pleckstrin-homology domain (PH domain) | 0.1541 | INHERITED FROM: protein subcellular localization variant || protein expression variant || drug induced gene expression variant || protein phosphorylation reduced |
| G proteins | 0.2042 | INHERITED FROM: protein subcellular localization variant || drug induced gene expression variant || protein phosphorylation variant |
| First domain of FERM | 0.2083 | INHERITED FROM: level of protein expression variant || protein expression reduced |
| Extended AAA-ATPase domain | 0.2296 | INHERITED FROM: protein expression increased |
| Transducin (alpha subunit), insertion domain | 0.2338 | INHERITED FROM: drug induced gene expression variant || protein phosphorylation reduced || protein phosphorylation variant |
| PLC-like (P variant) | 0.3399 | INHERITED FROM: protein subcellular localization variant || antimicrobial gene expression variant || pathogen induced antimicrobial gene expression variant || protein expression variant || drug induced gene expression variant || pathogen induced gene expression variant || transgene expression variant || transgene expression reduced |
| N-acetyl transferase, NAT | 0.3671 | INHERITED FROM: ectopic expression transgene |
| Third domain of FERM | 0.3973 | INHERITED FROM: level of protein expression variant || protein expression reduced |
| Double-stranded RNA-binding domain (dsRBD) | 0.3973 | INHERITED FROM: miRNA expression variant |
| Intermediate filament protein, coiled coil region | 0.4335 | INHERITED FROM: antibody staining variant || protein expression variant |
| Second domain of FERM | 0.4868 | INHERITED FROM: level of protein expression variant || protein expression reduced |
| Synaptotagmin-like (S variant) | 0.4868 | INHERITED FROM: protein subcellular localization variant || pattern protein expression variant |
| LIM domain | 0.4869 | INHERITED FROM: level of protein expression variant || protein expression reduced |
| Protein kinases, catalytic subunit | 0.5371 | INHERITED FROM: protein subcellular localization variant || protein expression variant || drug induced gene expression variant || protein phosphorylation reduced || transgene expression reduced || protein phosphorylation variant || protein modification variant |
| Spectrin repeat | 0.5467 | INHERITED FROM: antibody staining variant || level of protein expression variant |
| Lamin A/C globular tail domain | 0.5467 | INHERITED FROM: antibody staining variant || protein expression variant |
| Ubiquitin-related | 0.5836 | INHERITED FROM: transgene expression variant |
| SH2 domain | 0.6303 | INHERITED FROM: protein expression variant || level of protein expression variant || protein expression reduced |
| Nuclear receptor | 1 | INHERITED FROM: gene expression level high || gene expression level reduced || transgene expression reduced |
| Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: gene expression level high || gene expression level reduced || transgene expression reduced |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| POU-specific domain | 0 | Direct |
| PDI-like | 0 | Direct |
| CAT-like | 0 | Direct |
| RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | Direct |
| MIR domain | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| Nop domain | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| a tRNA synthase domain | 0 | Direct |
| Sir2 family of transcriptional regulators | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
| Brix domain | 0 | Direct |
| Heme-dependent catalases | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| FF domain | 0 | Direct |
| Cullin repeat | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| Tubulin, GTPase domain | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| L30e/L7ae ribosomal proteins | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Acyl-carrier protein (ACP) | 0 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| SCF ubiquitin ligase complex WHB domain | 0 | Direct |
| HSP20 | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| Clathrin adaptor core protein | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | Direct |
| RNA-polymerase beta | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| p120GAP domain-like | 0 | Direct |
| Proteasome subunits | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| Histone deacetylase, HDAC | 0 | Direct |
| Clathrin coat assembly domain | 0 | Direct |
| Erythroid transcription factor GATA-1 | 0 | Direct |
| Mammalian PLC | 0 | Direct |
| Chromo domain | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Trunk domain of Sec23/24 | 0 | Direct |
| Adenain-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| MIF4G domain-like | 0 | Direct |
| Integrin domains | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| ets domain | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| Tubulin, C-terminal domain | 0 | Direct |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
| RecA protein-like (ATPase-domain) | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Nucleosome core histones | 0.000000000000003129 | Direct |
| Actin/HSP70 | 0.000000004572 | Direct |
| UBC-related | 0.00000008393 | Direct |
| Forkhead DNA-binding domain | 0.000000307 | Direct |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.0000013 | Direct |
| PHD domain | 0.000001336 | Direct |
| Dual specificity phosphatase-like | 0.000003282 | Direct |
| Pepsin-like | 0.000003282 | Direct |
| Histone lysine methyltransferases | 0.00004426 | Direct |
| Papain-like | 0.00005275 | Direct |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.00006882 | Direct |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.0001677 | Direct |
| Bromodomain | 0.0002415 | Direct |
| Hect, E3 ligase catalytic domain | 0.0002854 | Direct |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.0003044 | Direct |
| Armadillo repeat | 0.0003073 | Direct |
| SMAD domain | 0.0007469 | Direct |
| Translational machinery components | 0.0007469 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0007469 | Direct |
| CCCH zinc finger | 0.0009152 | Direct |
| B-box zinc-binding domain | 0.001056 | Inherited |
| Cyclophilin (peptidylprolyl isomerase) | 0.002184 | Inherited |
| TBP-associated factors, TAFs | 0.002801 | Inherited |
| Cold shock DNA-binding domain-like | 0.003045 | Inherited |
| Canonical RBD | 0.004154 | Inherited |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.004183 | Inherited |
| PDZ domain | 0.00568 | Inherited |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.007675 | Inherited |
| Extended PAW domain | 0.008803 | Inherited |
| Ubiquitin activating enzymes (UBA) | 0.0129 | Inherited |
| Transforming growth factor (TGF)-beta | 0.0129 | Inherited |
| Frizzled cysteine-rich domain | 0.0129 | Inherited |
| EF-hand modules in multidomain proteins | 0.0129 | Inherited |
| Pumilio repeat | 0.01318 | Inherited |
| FKBP immunophilin/proline isomerase | 0.01318 | Inherited |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.01318 | Inherited |
| Cyclin | 0.01836 | Inherited |
| Elongation factors | 0.01836 | Inherited |
| Homeodomain | 0.01914 | Inherited |
| RING finger domain, C3HC4 | 0.02256 | Inherited |
| PAZ domain | 0.027 | Inherited |
| Leucine zipper domain | 0.02978 | Inherited |
| Biotinyl/lipoyl-carrier proteins and domains | 0.03099 | Inherited |
| Cdc48 domain 2-like | 0.03294 | Inherited |
| Anticodon-binding domain | 0.03294 | Inherited |
| Biotin dependent carboxylase carboxyltransferase domain | 0.03294 | Inherited |
| Cdc48 N-terminal domain-like | 0.03294 | Inherited |
| Chaperone J-domain | 0.04377 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.0499 | Inherited |
| PX domain | 0.0599 | Inherited |
| SH3-domain | 0.07594 | Inherited |
| DEP domain | 0.1049 | Inherited |
| WD40-repeat | 0.1098 | Inherited |
| Pleckstrin-homology domain (PH domain) | 0.1541 | Inherited |
| G proteins | 0.2042 | Inherited |
| First domain of FERM | 0.2083 | Inherited |
| Extended AAA-ATPase domain | 0.2296 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.2338 | Inherited |
| PLC-like (P variant) | 0.3399 | Inherited |
| N-acetyl transferase, NAT | 0.3671 | Inherited |
| Third domain of FERM | 0.3973 | Inherited |
| Double-stranded RNA-binding domain (dsRBD) | 0.3973 | Inherited |
| Intermediate filament protein, coiled coil region | 0.4335 | Inherited |
| Second domain of FERM | 0.4868 | Inherited |
| Synaptotagmin-like (S variant) | 0.4868 | Inherited |
| LIM domain | 0.4869 | Inherited |
| Protein kinases, catalytic subunit | 0.5371 | Inherited |
| Spectrin repeat | 0.5467 | Inherited |
| Lamin A/C globular tail domain | 0.5467 | Inherited |
| Ubiquitin-related | 0.5836 | Inherited |
| SH2 domain | 0.6303 | Inherited |
| Nuclear receptor | 1 | Inherited |
| Nuclear receptor ligand-binding domain | 1 | Inherited |
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Ribosomal protein L10-like | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| GroEL equatorial domain-like | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| S-adenosylmethionine synthetase | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| GroEL apical domain-like | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| ISP domain | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Histone-fold | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Chromo domain-like | 0.0000000002448 | DIRECT |
| FYVE/PHD zinc finger | 0.00000001252 | DIRECT |
| SET domain | 0.00000009259 | DIRECT |
| RING/U-box | 0.0000029 | DIRECT |
| Class II aaRS and biotin synthetases | 0.000002937 | DIRECT |
| Acid proteases | 0.000002937 | DIRECT |
| Cysteine-rich domain | 0.000003364 | DIRECT |
| SNARE-like | 0.000007486 | DIRECT |
| PAP/OAS1 substrate-binding domain | 0.00001398 | DIRECT |
| Translation proteins | 0.0000149 | DIRECT |
| Bromodomain | 0.00003832 | DIRECT |
| Translation proteins SH3-like domain | 0.0000626 | DIRECT |
| Hect, E3 ligase catalytic domain | 0.00007442 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00007442 | DIRECT |
| Cullin repeat-like | 0.00007442 | DIRECT |
| Arginase/deacetylase | 0.00007442 | DIRECT |
| CCCH zinc finger | 0.0000885 | DIRECT |
| B-box zinc-binding domain | 0.0001671 | DIRECT |
| ARM repeat | 0.0001742 | DIRECT |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.0001894 | DIRECT |
| Retrovirus zinc finger-like domains | 0.0003531 | DIRECT |
| Cyclophilin-like | 0.0004054 | DIRECT |
| ACP-like | 0.0007007 | DIRECT |
| ENTH/VHS domain | 0.000879 | DIRECT |
| Sm-like ribonucleoproteins | 0.001002 | INHERITED FROM: pattern of transgene expression variant || protein subcellular localization variant || transgene expression variant |
| RNA-binding domain, RBD | 0.001063 | INHERITED FROM: alternative splicing variant || RNA processing variant || no induction of antimicrobial peptide expression after infection || mRNA export variant || pathogen induced antimicrobial gene expression variant || RNA expression variant |
| "Winged helix" DNA-binding domain | 0.001063 | INHERITED FROM: protein expression increased |
| L30e-like | 0.001378 | INHERITED FROM: pattern of transgene expression variant || mRNA surveillance defective || RNA processing variant |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.001378 | INHERITED FROM: transgene subcellular localization variant || transgene expression variant |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.001856 | INHERITED FROM: transgene expression increased || protein expression reduced || level of transgene expression variant |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.002123 | INHERITED FROM: level of transgene expression variant || transgene expression variant |
| Tudor/PWWP/MBT | 0.002252 | INHERITED FROM: pattern of transgene expression variant |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.003738 | INHERITED FROM: pattern protein expression variant |
| Riboflavin synthase domain-like | 0.003738 | INHERITED FROM: pattern protein expression variant |
| PAZ domain | 0.00459 | INHERITED FROM: mRNA levels increased || siRNA expression variant || RNA expression variant || 21U RNA expression variant |
| FKBP-like | 0.004657 | INHERITED FROM: pattern of transgene expression variant || transgene subcellular localization variant |
| P-loop containing nucleoside triphosphate hydrolases | 0.004933 | INHERITED FROM: pattern of transgene expression variant |
| 4Fe-4S ferredoxins | 0.00636 | INHERITED FROM: transgene expression increased |
| Frizzled cysteine-rich domain | 0.00636 | INHERITED FROM: antibody staining variant || transgene expression reduced |
| Leucine zipper domain | 0.006825 | INHERITED FROM: mRNA levels reduced || mRNA expression variant || level of transgene expression variant || transgene expression reduced |
| Cyclin-like | 0.008468 | INHERITED FROM: level of transgene expression variant || protein phosphorylation reduced || protein phosphorylation variant |
| Zn-binding ribosomal proteins | 0.009892 | INHERITED FROM: mRNA surveillance defective || RNA processing variant || level of transgene expression variant |
| dsRNA-binding domain-like | 0.01051 | INHERITED FROM: RNA expression variant |
| DHS-like NAD/FAD-binding domain | 0.01138 | INHERITED FROM: protein acetylation variant || protein expression variant |
| Single hybrid motif | 0.01165 | INHERITED FROM: transgene expression increased || level of transgene expression variant |
| Saposin | 0.01773 | INHERITED FROM: level of transgene expression variant || transgene expression reduced |
| Cdc48 domain 2-like | 0.01883 | INHERITED FROM: transgene expression reduced |
| Integrin domains | 0.01883 | INHERITED FROM: level of protein expression variant || protein expression reduced || protein expression variant |
| ADC-like | 0.01883 | INHERITED FROM: transgene expression reduced |
| HIT/MYND zinc finger-like | 0.0217 | INHERITED FROM: pattern of transgene expression variant |
| p53-like transcription factors | 0.02269 | INHERITED FROM: level of transgene expression variant || gene expression level reduced || ectopic expression transgene |
| PH domain-like | 0.02291 | INHERITED FROM: level of protein expression variant || drug induced gene expression variant || protein phosphorylation variant || protein expression variant |
| PX domain | 0.02405 | INHERITED FROM: protein expression reduced || protein subcellular localization variant || protein expression variant |
| Homeodomain-like | 0.02786 | INHERITED FROM: level of transgene expression variant || ectopic expression transgene |
| SH3-domain | 0.0281 | INHERITED FROM: protein expression reduced || protein phosphorylation variant || protein expression variant |
| UBC-like | 0.03213 | INHERITED FROM: pattern of transgene expression variant || transgene subcellular localization variant |
| Chaperone J-domain | 0.04197 | INHERITED FROM: pattern of transgene expression variant || transgene expression variant |
| Actin-like ATPase domain | 0.04197 | INHERITED FROM: protein expression reduced || transgene expression variant |
| HLH, helix-loop-helix DNA-binding domain | 0.04797 | INHERITED FROM: gene expression level reduced || RNA expression variant || ectopic expression transgene |
| PDZ domain-like | 0.06179 | INHERITED FROM: protein expression variant |
| Tubby C-terminal domain-like | 0.06366 | INHERITED FROM: transgene expression reduced |
| CAD & PB1 domains | 0.06366 | INHERITED FROM: protein expression variant |
| ARID-like | 0.06366 | INHERITED FROM: protein expression variant |
| S15/NS1 RNA-binding domain | 0.06366 | INHERITED FROM: transgene expression increased |
| Protein kinase-like (PK-like) | 0.06784 | INHERITED FROM: protein modification variant || protein subcellular localization variant || protein phosphorylation reduced || drug induced gene expression variant || protein phosphorylation variant || transgene expression reduced || protein expression variant |
| Quinoprotein alcohol dehydrogenase-like | 0.07495 | INHERITED FROM: mRNA levels increased |
| Nucleic acid-binding proteins | 0.0781 | INHERITED FROM: mRNA surveillance defective |
| HSP20-like chaperones | 0.08159 | INHERITED FROM: transgene subcellular localization variant |
| DNase I-like | 0.1262 | INHERITED FROM: protein expression variant |
| PLC-like phosphodiesterases | 0.1262 | INHERITED FROM: protein expression variant |
| SAM/Pointed domain | 0.1312 | INHERITED FROM: gene expression level reduced |
| KA1-like | 0.1327 | INHERITED FROM: RNA expression variant |
| Cysteine proteinases | 0.1375 | INHERITED FROM: pattern of transgene expression variant |
| GTPase activation domain, GAP | 0.1763 | INHERITED FROM: protein expression variant |
| Nucleotidyltransferase | 0.2029 | INHERITED FROM: miRNA expression variant || RNA expression variant |
| HMG-box | 0.2302 | INHERITED FROM: transgene expression variant |
| Eukaryotic type KH-domain (KH-domain type I) | 0.2302 | INHERITED FROM: RNA expression variant |
| Transducin (alpha subunit), insertion domain | 0.2302 | INHERITED FROM: protein phosphorylation reduced || drug induced gene expression variant || protein phosphorylation variant |
| WD40 repeat-like | 0.2429 | INHERITED FROM: pathogen induced antimicrobial gene expression variant |
| SH2 domain | 0.2593 | INHERITED FROM: level of protein expression variant || protein expression reduced || protein expression variant |
| Second domain of FERM | 0.3711 | INHERITED FROM: level of protein expression variant || protein expression reduced |
| Nucleotidylyl transferase | 0.3897 | INHERITED FROM: transgene expression increased |
| Intermediate filament protein, coiled coil region | 0.4293 | INHERITED FROM: antibody staining variant || protein expression variant |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.4322 | INHERITED FROM: gene expression level high || level of transgene expression variant || transgene expression reduced || gene expression level reduced |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.4725 | INHERITED FROM: protein subcellular localization variant || drug induced gene expression variant || pathogen induced antimicrobial gene expression variant || protein expression variant |
| Lamin A/C globular tail domain | 0.4823 | INHERITED FROM: antibody staining variant || protein expression variant |
| PYP-like sensor domain (PAS domain) | 0.4823 | INHERITED FROM: transgene expression reduced || gene expression level reduced |
| Activating enzymes of the ubiquitin-like proteins | 0.4823 | INHERITED FROM: pattern of transgene expression variant || protein subcellular localization variant || transgene subcellular localization variant |
| Spectrin repeat | 0.4823 | INHERITED FROM: level of protein expression variant || antibody staining variant |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.5464 | INHERITED FROM: transgene expression variant |
| Ribonuclease H-like | 0.5748 | INHERITED FROM: siRNA expression variant || RNA expression variant || 21U RNA expression variant |
| Clavaminate synthase-like | 0.6743 | INHERITED FROM: histone methylation variant || protein methylation variant |
| Nuclear receptor ligand-binding domain | 0.9271 | INHERITED FROM: gene expression level high || level of transgene expression variant || transgene expression reduced || gene expression level reduced |
| ClpP/crotonase | 1 | INHERITED FROM: level of transgene expression variant |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Ribosomal protein L10-like | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| GroEL equatorial domain-like | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| S-adenosylmethionine synthetase | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| GroEL apical domain-like | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| Tubulin nucleotide-binding domain-like | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| GroEL-intermediate domain like | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| FF domain | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Nop domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| ISP domain | 0 | Direct |
| Cytochrome c | 0 | Direct |
| MIR domain | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Histone-fold | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Chromo domain-like | 0.0000000002448 | Direct |
| FYVE/PHD zinc finger | 0.00000001252 | Direct |
| SET domain | 0.00000009259 | Direct |
| RING/U-box | 0.0000029 | Direct |
| Class II aaRS and biotin synthetases | 0.000002937 | Direct |
| Acid proteases | 0.000002937 | Direct |
| Cysteine-rich domain | 0.000003364 | Direct |
| SNARE-like | 0.000007486 | Direct |
| PAP/OAS1 substrate-binding domain | 0.00001398 | Direct |
| Translation proteins | 0.0000149 | Direct |
| Bromodomain | 0.00003832 | Direct |
| Translation proteins SH3-like domain | 0.0000626 | Direct |
| Hect, E3 ligase catalytic domain | 0.00007442 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00007442 | Direct |
| Cullin repeat-like | 0.00007442 | Direct |
| Arginase/deacetylase | 0.00007442 | Direct |
| CCCH zinc finger | 0.0000885 | Direct |
| B-box zinc-binding domain | 0.0001671 | Direct |
| ARM repeat | 0.0001742 | Direct |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.0001894 | Direct |
| Retrovirus zinc finger-like domains | 0.0003531 | Direct |
| Cyclophilin-like | 0.0004054 | Direct |
| ACP-like | 0.0007007 | Direct |
| ENTH/VHS domain | 0.000879 | Direct |
| Sm-like ribonucleoproteins | 0.001002 | Inherited |
| RNA-binding domain, RBD | 0.001063 | Inherited |
| "Winged helix" DNA-binding domain | 0.001063 | Inherited |
| L30e-like | 0.001378 | Inherited |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.001378 | Inherited |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.001856 | Inherited |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.002123 | Inherited |
| Tudor/PWWP/MBT | 0.002252 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.003738 | Inherited |
| Riboflavin synthase domain-like | 0.003738 | Inherited |
| PAZ domain | 0.00459 | Inherited |
| FKBP-like | 0.004657 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 0.004933 | Inherited |
| 4Fe-4S ferredoxins | 0.00636 | Inherited |
| Frizzled cysteine-rich domain | 0.00636 | Inherited |
| Leucine zipper domain | 0.006825 | Inherited |
| Cyclin-like | 0.008468 | Inherited |
| Zn-binding ribosomal proteins | 0.009892 | Inherited |
| dsRNA-binding domain-like | 0.01051 | Inherited |
| DHS-like NAD/FAD-binding domain | 0.01138 | Inherited |
| Single hybrid motif | 0.01165 | Inherited |
| Saposin | 0.01773 | Inherited |
| Cdc48 domain 2-like | 0.01883 | Inherited |
| Integrin domains | 0.01883 | Inherited |
| ADC-like | 0.01883 | Inherited |
| HIT/MYND zinc finger-like | 0.0217 | Inherited |
| p53-like transcription factors | 0.02269 | Inherited |
| PH domain-like | 0.02291 | Inherited |
| PX domain | 0.02405 | Inherited |
| Homeodomain-like | 0.02786 | Inherited |
| SH3-domain | 0.0281 | Inherited |
| UBC-like | 0.03213 | Inherited |
| Chaperone J-domain | 0.04197 | Inherited |
| Actin-like ATPase domain | 0.04197 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.04797 | Inherited |
| PDZ domain-like | 0.06179 | Inherited |
| Tubby C-terminal domain-like | 0.06366 | Inherited |
| CAD & PB1 domains | 0.06366 | Inherited |
| ARID-like | 0.06366 | Inherited |
| S15/NS1 RNA-binding domain | 0.06366 | Inherited |
| Protein kinase-like (PK-like) | 0.06784 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.07495 | Inherited |
| Nucleic acid-binding proteins | 0.0781 | Inherited |
| HSP20-like chaperones | 0.08159 | Inherited |
| DNase I-like | 0.1262 | Inherited |
| PLC-like phosphodiesterases | 0.1262 | Inherited |
| SAM/Pointed domain | 0.1312 | Inherited |
| KA1-like | 0.1327 | Inherited |
| Cysteine proteinases | 0.1375 | Inherited |
| GTPase activation domain, GAP | 0.1763 | Inherited |
| Nucleotidyltransferase | 0.2029 | Inherited |
| HMG-box | 0.2302 | Inherited |
| Eukaryotic type KH-domain (KH-domain type I) | 0.2302 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.2302 | Inherited |
| WD40 repeat-like | 0.2429 | Inherited |
| SH2 domain | 0.2593 | Inherited |
| Second domain of FERM | 0.3711 | Inherited |
| Nucleotidylyl transferase | 0.3897 | Inherited |
| Intermediate filament protein, coiled coil region | 0.4293 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.4322 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.4725 | Inherited |
| Lamin A/C globular tail domain | 0.4823 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.4823 | Inherited |
| Activating enzymes of the ubiquitin-like proteins | 0.4823 | Inherited |
| Spectrin repeat | 0.4823 | Inherited |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.5464 | Inherited |
| Ribonuclease H-like | 0.5748 | Inherited |
| Clavaminate synthase-like | 0.6743 | Inherited |
| Nuclear receptor ligand-binding domain | 0.9271 | Inherited |
| ClpP/crotonase | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | DIRECT |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0 | DIRECT |
54495,46934
54495 - UBC-like
46934 - UBA-like | 0 | DIRECT |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
144232,82199
144232 - HIT/MYND zinc finger-like
82199 - SET domain | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | DIRECT |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | DIRECT |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | DIRECT |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | DIRECT |
55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | DIRECT |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0 | DIRECT |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | DIRECT |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
55729,55729
55729 - Acyl-CoA N-acyltransferases (Nat)
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | DIRECT |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | DIRECT |
57903,82199
57903 - FYVE/PHD zinc finger
82199 - SET domain | 0 | DIRECT |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
64356,49447
64356 - SNARE-like
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0 | DIRECT |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | DIRECT |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0.000007486 | DIRECT |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.000007486 | DIRECT |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00007442 | DIRECT |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.00007779 | DIRECT |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.0004404 | DIRECT |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0.0007007 | DIRECT |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.001378 | INHERITED FROM: transgene subcellular localization variant || transgene expression variant |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.001378 | INHERITED FROM: pathogen induced gene expression variant || protein subcellular localization variant || drug induced gene expression variant || pathogen induced antimicrobial gene expression variant || antimicrobial gene expression variant |
51045,51045
51045 - WW domain
51045 - WW domain | 0.002123 | INHERITED FROM: transgene expression variant |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.002253 | INHERITED FROM: mRNA levels reduced || mRNA levels increased || protein phosphorylation increased || protein phosphorylation variant || transgene expression variant |
57850,57845
57850 - RING/U-box
57845 - B-box zinc-binding domain | 0.005095 | INHERITED FROM: transgene subcellular localization variant |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.00636 | INHERITED FROM: pattern protein expression variant || protein subcellular localization variant || protein expression variant |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0.009601 | INHERITED FROM: mRNA expression ectopic || ectopic expression transgene |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0.009892 | INHERITED FROM: protein expression reduced |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.009892 | INHERITED FROM: protein expression reduced |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.01883 | INHERITED FROM: level of protein expression variant || protein expression reduced || protein expression variant |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.04197 | INHERITED FROM: protein expression reduced || transgene expression variant |
57850,57850
57850 - RING/U-box
57850 - RING/U-box | 0.04328 | INHERITED FROM: transgene subcellular localization variant |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0.06366 | INHERITED FROM: transgene expression increased |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.1568 | INHERITED FROM: protein expression reduced || protein expression variant |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.2302 | INHERITED FROM: protein phosphorylation reduced || drug induced gene expression variant || protein phosphorylation variant |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.2852 | INHERITED FROM: level of protein expression variant || protein expression reduced || protein expression variant |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.3813 | INHERITED FROM: pattern of transgene expression variant |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0.5089 | INHERITED FROM: level of protein expression variant || protein expression reduced |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0.5464 | INHERITED FROM: antibody staining variant || protein expression variant |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.5464 | INHERITED FROM: transgene expression variant |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.6117 | INHERITED FROM: level of protein expression variant || antibody staining variant |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.7586 | INHERITED FROM: protein expression reduced |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | Direct |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | Direct |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0 | Direct |
54495,46934
54495 - UBC-like
46934 - UBA-like | 0 | Direct |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
144232,82199
144232 - HIT/MYND zinc finger-like
82199 - SET domain | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | Direct |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | Direct |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | Direct |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0 | Direct |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | Direct |
55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | Direct |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0 | Direct |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | Direct |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
55729,55729
55729 - Acyl-CoA N-acyltransferases (Nat)
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | Direct |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | Direct |
57903,82199
57903 - FYVE/PHD zinc finger
82199 - SET domain | 0 | Direct |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
64356,49447
64356 - SNARE-like
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0 | Direct |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | Direct |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0.000007486 | Direct |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.000007486 | Direct |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00007442 | Direct |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.00007779 | Direct |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.0004404 | Direct |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0.0007007 | Direct |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.001378 | Inherited |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.001378 | Inherited |
51045,51045
51045 - WW domain
51045 - WW domain | 0.002123 | Inherited |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.002253 | Inherited |
57850,57845
57850 - RING/U-box
57845 - B-box zinc-binding domain | 0.005095 | Inherited |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.00636 | Inherited |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0.009601 | Inherited |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0.009892 | Inherited |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.009892 | Inherited |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.01883 | Inherited |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.04197 | Inherited |
57850,57850
57850 - RING/U-box
57850 - RING/U-box | 0.04328 | Inherited |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0.06366 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.1568 | Inherited |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.2302 | Inherited |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.2852 | Inherited |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.3813 | Inherited |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0.5089 | Inherited |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0.5464 | Inherited |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.5464 | Inherited |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.6117 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.7586 | Inherited |
(show details)
Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0 | DIRECT |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
55973,55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | DIRECT |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00007442 | DIRECT |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.001378 | INHERITED FROM: transgene subcellular localization variant || transgene expression variant |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0.01138 | INHERITED FROM: pattern of transgene expression variant || transgene subcellular localization variant |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0.4272 | INHERITED FROM: level of protein expression variant || protein expression reduced |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.4293 | INHERITED FROM: pattern of transgene expression variant |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.4293 | INHERITED FROM: level of protein expression variant || protein expression reduced || protein expression variant |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.6117 | INHERITED FROM: level of protein expression variant || antibody staining variant |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.9656 | INHERITED FROM: protein expression reduced |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0 | Direct |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
55973,55973,55973
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase
55973 - S-adenosylmethionine synthetase | 0 | Direct |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00007442 | Direct |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.001378 | Inherited |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0.01138 | Inherited |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0.4272 | Inherited |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.4293 | Inherited |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.4293 | Inherited |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.6117 | Inherited |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.9656 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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