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Worm Phenotype (WP): cell death variant
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| PX domain | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| DLC | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| VPS9 domain | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0.000000545 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.0000009103 | DIRECT |
| Cullin repeat-like | 0.000002221 | DIRECT |
| Skp1 dimerisation domain-like | 0.00001116 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0.0001264 | DIRECT |
| Integrin domains | 0.0001264 | DIRECT |
| FYVE/PHD zinc finger | 0.0004895 | DIRECT |
| Tubby C-terminal domain-like | 0.0005535 | DIRECT |
| Cupredoxins | 0.0005535 | DIRECT |
| Caspase-like | 0.0005535 | DIRECT |
| Cullin homology domain | 0.0009013 | DIRECT |
| GroEL apical domain-like | 0.001771 | INHERITED FROM: apoptosis variant || accumulated cell corpses || programmed cell death variant || accumulated germline cell corpses |
| GroEL-intermediate domain like | 0.004691 | INHERITED FROM: apoptosis variant || accumulated cell corpses || programmed cell death variant || accumulated germline cell corpses |
| GroEL equatorial domain-like | 0.004691 | INHERITED FROM: apoptosis variant || accumulated cell corpses || programmed cell death variant || accumulated germline cell corpses |
| Cysteine proteinases | 0.005449 | INHERITED FROM: necrotic cell death variant |
| ENTH/VHS domain | 0.005855 | INHERITED FROM: apoptosis variant || accumulated cell corpses || programmed cell death variant || accumulated germline cell corpses |
| Sm-like ribonucleoproteins | 0.005855 | INHERITED FROM: apoptosis variant || programmed cell death variant |
| Protein kinase-like (PK-like) | 0.01013 | INHERITED FROM: cell corpse number decreased || mutagen induced apoptosis variant || non apoptotic cell death variant |
| BAR/IMD domain-like | 0.01395 | INHERITED FROM: apoptosis variant || programmed cell death variant || accumulated germline cell corpses |
| Calcium ATPase, transmembrane domain M | 0.01436 | INHERITED FROM: cell corpse number variant || accumulated cell corpses |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.01436 | INHERITED FROM: cell corpse number variant || accumulated cell corpses |
| F1F0 ATP synthase subunit C | 0.02242 | INHERITED FROM: programmed cell death variant |
| DNA repair protein MutS, domain III | 0.02242 | INHERITED FROM: radiation induced reproductive cell death variant || induced cell death variant || programmed cell death variant || non apoptotic cell death variant |
| 5' to 3' exonuclease, C-terminal subdomain | 0.02242 | INHERITED FROM: apoptosis variant || cell corpse appearance delayed || apoptosis protracted || programmed cell death variant |
| DEATH domain | 0.03036 | INHERITED FROM: apoptosis variant || programmed cell death variant |
| Activating enzymes of the ubiquitin-like proteins | 0.03036 | INHERITED FROM: apoptosis variant || cell corpse number variant || accumulated cell corpses || programmed cell death variant |
| Calcium ATPase, transduction domain A | 0.03128 | INHERITED FROM: cell corpse number variant || accumulated cell corpses |
| SH3-domain | 0.05556 | INHERITED FROM: apoptosis variant || accumulated cell corpses || programmed cell death variant |
| SET domain | 0.07101 | INHERITED FROM: apoptosis increased |
| Hect, E3 ligase catalytic domain | 0.0736 | INHERITED FROM: cell corpse number variant |
| PH domain-like | 0.07708 | INHERITED FROM: apoptosis variant || programmed cell death variant |
| ARM repeat | 0.0992 | INHERITED FROM: accumulated somatic cell corpses |
| Lamin A/C globular tail domain | 0.1304 | INHERITED FROM: cell corpse number decreased || cell corpse number variant || somatic cell death variant |
| PIN domain-like | 0.1499 | INHERITED FROM: cell corpse appearance delayed || apoptosis protracted |
| Sec1/munc18-like (SM) proteins | 0.1499 | INHERITED FROM: cell corpse number variant || accumulated cell corpses || accumulated germline cell corpses |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0.1499 | INHERITED FROM: cell corpse number variant || accumulated cell corpses || accumulated germline cell corpses |
| HLH, helix-loop-helix DNA-binding domain | 0.1624 | INHERITED FROM: apoptosis fails to occur |
| SNARE-like | 0.171 | INHERITED FROM: apoptosis variant || programmed cell death variant |
| POZ domain | 0.2007 | INHERITED FROM: cell corpse number variant || accumulated cell corpses || apoptosis increased || accumulated germline cell corpses |
| Saposin | 0.2239 | INHERITED FROM: radiation induced germ cell apoptosis variant || mutagen induced apoptosis variant |
| Intermediate filament protein, coiled coil region | 0.2432 | INHERITED FROM: cell corpse number decreased || somatic cell death variant |
| "Winged helix" DNA-binding domain | 0.4309 | INHERITED FROM: apoptosis variant || accumulated germline cell corpses |
| Chromo domain-like | 0.4445 | INHERITED FROM: apoptosis increased |
| WD40 repeat-like | 0.4636 | INHERITED FROM: programmed cell death variant |
| Nucleic acid-binding proteins | 0.477 | INHERITED FROM: apoptosis variant || programmed cell death variant |
| Histone-fold | 0.5068 | INHERITED FROM: cell corpse degradation variant || apoptosis variant || accumulated cell corpses || programmed cell death variant |
| Metallo-dependent phosphatases | 0.6095 | INHERITED FROM: radiation induced germ cell apoptosis variant || mutagen induced apoptosis variant |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.6881 | INHERITED FROM: gamma ray induced apoptosis increased |
| PLP-dependent transferases | 0.7077 | INHERITED FROM: radiation induced germ cell apoptosis variant || mutagen induced apoptosis variant |
| RNA-binding domain, RBD | 1 | INHERITED FROM: starvation induced apoptosis variant |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| PX domain | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| DLC | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| VPS9 domain | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0.000000545 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.0000009103 | Direct |
| Cullin repeat-like | 0.000002221 | Direct |
| Skp1 dimerisation domain-like | 0.00001116 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0.0001264 | Direct |
| Integrin domains | 0.0001264 | Direct |
| FYVE/PHD zinc finger | 0.0004895 | Direct |
| Tubby C-terminal domain-like | 0.0005535 | Direct |
| Cupredoxins | 0.0005535 | Direct |
| Caspase-like | 0.0005535 | Direct |
| Cullin homology domain | 0.0009013 | Direct |
| GroEL apical domain-like | 0.001771 | Inherited |
| GroEL-intermediate domain like | 0.004691 | Inherited |
| GroEL equatorial domain-like | 0.004691 | Inherited |
| Cysteine proteinases | 0.005449 | Inherited |
| ENTH/VHS domain | 0.005855 | Inherited |
| Sm-like ribonucleoproteins | 0.005855 | Inherited |
| Protein kinase-like (PK-like) | 0.01013 | Inherited |
| BAR/IMD domain-like | 0.01395 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.01436 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.01436 | Inherited |
| F1F0 ATP synthase subunit C | 0.02242 | Inherited |
| DNA repair protein MutS, domain III | 0.02242 | Inherited |
| 5' to 3' exonuclease, C-terminal subdomain | 0.02242 | Inherited |
| DEATH domain | 0.03036 | Inherited |
| Activating enzymes of the ubiquitin-like proteins | 0.03036 | Inherited |
| Calcium ATPase, transduction domain A | 0.03128 | Inherited |
| SH3-domain | 0.05556 | Inherited |
| SET domain | 0.07101 | Inherited |
| Hect, E3 ligase catalytic domain | 0.0736 | Inherited |
| PH domain-like | 0.07708 | Inherited |
| ARM repeat | 0.0992 | Inherited |
| Lamin A/C globular tail domain | 0.1304 | Inherited |
| PIN domain-like | 0.1499 | Inherited |
| Sec1/munc18-like (SM) proteins | 0.1499 | Inherited |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0.1499 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.1624 | Inherited |
| SNARE-like | 0.171 | Inherited |
| POZ domain | 0.2007 | Inherited |
| Saposin | 0.2239 | Inherited |
| Intermediate filament protein, coiled coil region | 0.2432 | Inherited |
| "Winged helix" DNA-binding domain | 0.4309 | Inherited |
| Chromo domain-like | 0.4445 | Inherited |
| WD40 repeat-like | 0.4636 | Inherited |
| Nucleic acid-binding proteins | 0.477 | Inherited |
| Histone-fold | 0.5068 | Inherited |
| Metallo-dependent phosphatases | 0.6095 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.6881 | Inherited |
| PLP-dependent transferases | 0.7077 | Inherited |
| RNA-binding domain, RBD | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this WP term (SDWP level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| PX domain | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| DLC | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Myotubularin-like phosphatases | 0 | DIRECT |
| SCF ubiquitin ligase complex WHB domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| RNA-polymerase beta | 0 | DIRECT |
| Protein prenyltransferases | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Arginine methyltransferase | 0 | DIRECT |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.000000000000001565 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0.000001457 | DIRECT |
| RecA protein-like (ATPase-domain) | 0.000002052 | DIRECT |
| Skp1 dimerisation domain-like | 0.00001154 | DIRECT |
| Ephrin ectodomain | 0.0001985 | DIRECT |
| Caspase catalytic domain | 0.0001985 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0.0002713 | DIRECT |
| Calpain large subunit, catalytic domain (domain II) | 0.0003246 | DIRECT |
| Cullin homology domain | 0.0008052 | DIRECT |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.0008052 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.00162 | INHERITED FROM: apoptosis variant || accumulated germline cell corpses |
| BTB/POZ domain | 0.006254 | INHERITED FROM: apoptosis variant || cell corpse number variant || accumulated cell corpses || programmed cell death variant || apoptosis increased || accumulated germline cell corpses |
| G proteins | 0.006635 | INHERITED FROM: apoptosis variant |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.01106 | INHERITED FROM: apoptosis variant |
| BAR domain | 0.02013 | INHERITED FROM: apoptosis variant || cell corpse number variant || accumulated cell corpses || programmed cell death variant || accumulated germline cell corpses |
| Ubiquitin activating enzymes (UBA) | 0.02013 | INHERITED FROM: apoptosis variant || cell corpse number variant || accumulated cell corpses || programmed cell death variant || apoptosis increased || accumulated germline cell corpses |
| DNA repair protein MutS, domain III | 0.02013 | INHERITED FROM: radiation induced reproductive cell death variant || induced cell death variant || programmed cell death variant || non apoptotic cell death variant |
| F1F0 ATP synthase subunit C | 0.02013 | INHERITED FROM: programmed cell death variant |
| 5' to 3' exonuclease catalytic domain | 0.02013 | INHERITED FROM: apoptosis variant || cell corpse appearance delayed || apoptosis protracted || programmed cell death variant |
| 5' to 3' exonuclease, C-terminal subdomain | 0.02013 | INHERITED FROM: apoptosis variant || cell corpse appearance delayed || apoptosis protracted || programmed cell death variant |
| Cold shock DNA-binding domain-like | 0.02564 | INHERITED FROM: apoptosis variant || programmed cell death variant |
| Calcium ATPase, transduction domain A | 0.02962 | INHERITED FROM: cell corpse number variant || accumulated cell corpses |
| Protein kinases, catalytic subunit | 0.05292 | INHERITED FROM: mutagen induced apoptosis variant || non apoptotic cell death variant |
| Histone lysine methyltransferases | 0.056 | INHERITED FROM: apoptosis increased |
| SH3-domain | 0.0571 | INHERITED FROM: apoptosis variant || accumulated cell corpses || programmed cell death variant |
| Clathrin adaptor core protein | 0.06693 | INHERITED FROM: apoptosis variant || accumulated cell corpses || programmed cell death variant || accumulated somatic cell corpses || accumulated germline cell corpses |
| Hect, E3 ligase catalytic domain | 0.06809 | INHERITED FROM: cell corpse number variant |
| Phosphotyrosine-binding domain (PTB) | 0.1074 | INHERITED FROM: apoptosis variant || accumulated cell corpses || accumulated germline cell corpses |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0.1414 | INHERITED FROM: cell corpse number variant || accumulated cell corpses || accumulated germline cell corpses |
| Sec1/munc18-like (SM) proteins | 0.1414 | INHERITED FROM: cell corpse number variant || accumulated cell corpses || accumulated germline cell corpses |
| HLH, helix-loop-helix DNA-binding domain | 0.1622 | INHERITED FROM: apoptosis fails to occur |
| Intermediate filament protein, coiled coil region | 0.2338 | INHERITED FROM: cell corpse number decreased || somatic cell death variant |
| Translational machinery components | 0.2338 | INHERITED FROM: apoptosis reduced |
| Armadillo repeat | 0.2786 | INHERITED FROM: accumulated somatic cell corpses |
| Nucleosome core histones | 0.4925 | INHERITED FROM: cell corpse degradation variant || apoptosis variant || accumulated cell corpses || programmed cell death variant |
| Proteasome subunits | 0.6156 | INHERITED FROM: apoptosis reduced |
| ABC transporter ATPase domain-like | 0.7758 | INHERITED FROM: radiation induced reproductive cell death variant || induced cell death variant |
| Canonical RBD | 1 | INHERITED FROM: starvation induced apoptosis variant |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| PX domain | 0 | Direct |
| Cullin repeat | 0 | Direct |
| DLC | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Myotubularin-like phosphatases | 0 | Direct |
| SCF ubiquitin ligase complex WHB domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| RNA-polymerase beta | 0 | Direct |
| Protein prenyltransferases | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| Integrin domains | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Arginine methyltransferase | 0 | Direct |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.000000000000001565 | Direct |
| Calpain large subunit, middle domain (domain III) | 0.000001457 | Direct |
| RecA protein-like (ATPase-domain) | 0.000002052 | Direct |
| Skp1 dimerisation domain-like | 0.00001154 | Direct |
| Ephrin ectodomain | 0.0001985 | Direct |
| Caspase catalytic domain | 0.0001985 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0.0002713 | Direct |
| Calpain large subunit, catalytic domain (domain II) | 0.0003246 | Direct |
| Cullin homology domain | 0.0008052 | Direct |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.0008052 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.00162 | Inherited |
| BTB/POZ domain | 0.006254 | Inherited |
| G proteins | 0.006635 | Inherited |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.01106 | Inherited |
| BAR domain | 0.02013 | Inherited |
| Ubiquitin activating enzymes (UBA) | 0.02013 | Inherited |
| DNA repair protein MutS, domain III | 0.02013 | Inherited |
| F1F0 ATP synthase subunit C | 0.02013 | Inherited |
| 5' to 3' exonuclease catalytic domain | 0.02013 | Inherited |
| 5' to 3' exonuclease, C-terminal subdomain | 0.02013 | Inherited |
| Cold shock DNA-binding domain-like | 0.02564 | Inherited |
| Calcium ATPase, transduction domain A | 0.02962 | Inherited |
| Protein kinases, catalytic subunit | 0.05292 | Inherited |
| Histone lysine methyltransferases | 0.056 | Inherited |
| SH3-domain | 0.0571 | Inherited |
| Clathrin adaptor core protein | 0.06693 | Inherited |
| Hect, E3 ligase catalytic domain | 0.06809 | Inherited |
| Phosphotyrosine-binding domain (PTB) | 0.1074 | Inherited |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0.1414 | Inherited |
| Sec1/munc18-like (SM) proteins | 0.1414 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.1622 | Inherited |
| Intermediate filament protein, coiled coil region | 0.2338 | Inherited |
| Translational machinery components | 0.2338 | Inherited |
| Armadillo repeat | 0.2786 | Inherited |
| Nucleosome core histones | 0.4925 | Inherited |
| Proteasome subunits | 0.6156 | Inherited |
| ABC transporter ATPase domain-like | 0.7758 | Inherited |
| Canonical RBD | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Plot tree as:
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Download Newick format tree:
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this WP term (SPWP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| VPS9 domain | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| DLC | 0 | DIRECT |
| PX domain | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0.0000004394 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.0000007353 | DIRECT |
| Cullin repeat-like | 0.0000018 | DIRECT |
| Skp1 dimerisation domain-like | 0.000009084 | DIRECT |
| Integrin domains | 0.0001036 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0.0001036 | DIRECT |
| FYVE/PHD zinc finger | 0.0004051 | DIRECT |
| Tubby C-terminal domain-like | 0.0004585 | DIRECT |
| Cupredoxins | 0.0004585 | DIRECT |
| Caspase-like | 0.0004585 | DIRECT |
| Cullin homology domain | 0.0007498 | DIRECT |
| GroEL apical domain-like | 0.001482 | INHERITED FROM: accumulated germline cell corpses || programmed cell death variant || accumulated cell corpses || apoptosis variant |
| GroEL equatorial domain-like | 0.003982 | INHERITED FROM: accumulated germline cell corpses || programmed cell death variant || accumulated cell corpses || apoptosis variant |
| GroEL-intermediate domain like | 0.003982 | INHERITED FROM: accumulated germline cell corpses || programmed cell death variant || accumulated cell corpses || apoptosis variant |
| Cysteine proteinases | 0.004633 | INHERITED FROM: necrotic cell death variant |
| ENTH/VHS domain | 0.004985 | INHERITED FROM: accumulated germline cell corpses || programmed cell death variant || accumulated cell corpses || apoptosis variant |
| Sm-like ribonucleoproteins | 0.004985 | INHERITED FROM: programmed cell death variant || apoptosis variant |
| Protein kinase-like (PK-like) | 0.008713 | INHERITED FROM: mutagen induced apoptosis variant || cell corpse number decreased || non apoptotic cell death variant |
| BAR/IMD domain-like | 0.01207 | INHERITED FROM: accumulated germline cell corpses || programmed cell death variant || apoptosis variant |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.01243 | INHERITED FROM: cell corpse number variant || accumulated cell corpses |
| Calcium ATPase, transmembrane domain M | 0.01243 | INHERITED FROM: cell corpse number variant || accumulated cell corpses |
| F1F0 ATP synthase subunit C | 0.01956 | INHERITED FROM: programmed cell death variant |
| DNA repair protein MutS, domain III | 0.01956 | INHERITED FROM: induced cell death variant || programmed cell death variant || non apoptotic cell death variant || radiation induced reproductive cell death variant |
| 5' to 3' exonuclease, C-terminal subdomain | 0.01956 | INHERITED FROM: apoptosis protracted || programmed cell death variant || cell corpse appearance delayed || apoptosis variant |
| Activating enzymes of the ubiquitin-like proteins | 0.02666 | INHERITED FROM: programmed cell death variant || cell corpse number variant || accumulated cell corpses || apoptosis variant |
| DEATH domain | 0.02666 | INHERITED FROM: programmed cell death variant || apoptosis variant |
| Calcium ATPase, transduction domain A | 0.02749 | INHERITED FROM: cell corpse number variant || accumulated cell corpses |
| SH3-domain | 0.04936 | INHERITED FROM: programmed cell death variant || accumulated cell corpses || apoptosis variant |
| SET domain | 0.0635 | INHERITED FROM: apoptosis increased |
| Hect, E3 ligase catalytic domain | 0.06585 | INHERITED FROM: cell corpse number variant |
| PH domain-like | 0.06906 | INHERITED FROM: programmed cell death variant || apoptosis variant |
| ARM repeat | 0.08954 | INHERITED FROM: accumulated somatic cell corpses |
| Lamin A/C globular tail domain | 0.1185 | INHERITED FROM: cell corpse number decreased || cell corpse number variant || somatic cell death variant |
| PIN domain-like | 0.1367 | INHERITED FROM: apoptosis protracted || cell corpse appearance delayed |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0.1367 | INHERITED FROM: accumulated germline cell corpses || cell corpse number variant || accumulated cell corpses || apoptosis variant |
| Sec1/munc18-like (SM) proteins | 0.1367 | INHERITED FROM: accumulated germline cell corpses || cell corpse number variant || accumulated cell corpses || apoptosis variant |
| HLH, helix-loop-helix DNA-binding domain | 0.1486 | INHERITED FROM: apoptosis fails to occur |
| SNARE-like | 0.1568 | INHERITED FROM: programmed cell death variant || apoptosis variant |
| POZ domain | 0.1848 | INHERITED FROM: accumulated germline cell corpses || apoptosis increased || cell corpse number variant || accumulated cell corpses |
| Saposin | 0.207 | INHERITED FROM: mutagen induced apoptosis variant || radiation induced germ cell apoptosis variant |
| Intermediate filament protein, coiled coil region | 0.2256 | INHERITED FROM: cell corpse number decreased || somatic cell death variant |
| "Winged helix" DNA-binding domain | 0.4102 | INHERITED FROM: accumulated germline cell corpses || apoptosis variant |
| Chromo domain-like | 0.4235 | INHERITED FROM: apoptosis increased |
| WD40 repeat-like | 0.4425 | INHERITED FROM: programmed cell death variant |
| Nucleic acid-binding proteins | 0.4556 | INHERITED FROM: programmed cell death variant || apoptosis variant |
| Histone-fold | 0.485 | INHERITED FROM: programmed cell death variant || cell corpse degradation variant || accumulated cell corpses || apoptosis variant |
| Metallo-dependent phosphatases | 0.5874 | INHERITED FROM: mutagen induced apoptosis variant || radiation induced germ cell apoptosis variant |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.667 | INHERITED FROM: gamma ray induced apoptosis increased |
| PLP-dependent transferases | 0.687 | INHERITED FROM: mutagen induced apoptosis variant || radiation induced germ cell apoptosis variant |
| RNA-binding domain, RBD | 1 | INHERITED FROM: starvation induced apoptosis variant |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Clathrin adaptor appendage domain | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| VPS9 domain | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| DLC | 0 | Direct |
| PX domain | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0.0000004394 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.0000007353 | Direct |
| Cullin repeat-like | 0.0000018 | Direct |
| Skp1 dimerisation domain-like | 0.000009084 | Direct |
| Integrin domains | 0.0001036 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0.0001036 | Direct |
| FYVE/PHD zinc finger | 0.0004051 | Direct |
| Tubby C-terminal domain-like | 0.0004585 | Direct |
| Cupredoxins | 0.0004585 | Direct |
| Caspase-like | 0.0004585 | Direct |
| Cullin homology domain | 0.0007498 | Direct |
| GroEL apical domain-like | 0.001482 | Inherited |
| GroEL equatorial domain-like | 0.003982 | Inherited |
| GroEL-intermediate domain like | 0.003982 | Inherited |
| Cysteine proteinases | 0.004633 | Inherited |
| ENTH/VHS domain | 0.004985 | Inherited |
| Sm-like ribonucleoproteins | 0.004985 | Inherited |
| Protein kinase-like (PK-like) | 0.008713 | Inherited |
| BAR/IMD domain-like | 0.01207 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.01243 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.01243 | Inherited |
| F1F0 ATP synthase subunit C | 0.01956 | Inherited |
| DNA repair protein MutS, domain III | 0.01956 | Inherited |
| 5' to 3' exonuclease, C-terminal subdomain | 0.01956 | Inherited |
| Activating enzymes of the ubiquitin-like proteins | 0.02666 | Inherited |
| DEATH domain | 0.02666 | Inherited |
| Calcium ATPase, transduction domain A | 0.02749 | Inherited |
| SH3-domain | 0.04936 | Inherited |
| SET domain | 0.0635 | Inherited |
| Hect, E3 ligase catalytic domain | 0.06585 | Inherited |
| PH domain-like | 0.06906 | Inherited |
| ARM repeat | 0.08954 | Inherited |
| Lamin A/C globular tail domain | 0.1185 | Inherited |
| PIN domain-like | 0.1367 | Inherited |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0.1367 | Inherited |
| Sec1/munc18-like (SM) proteins | 0.1367 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.1486 | Inherited |
| SNARE-like | 0.1568 | Inherited |
| POZ domain | 0.1848 | Inherited |
| Saposin | 0.207 | Inherited |
| Intermediate filament protein, coiled coil region | 0.2256 | Inherited |
| "Winged helix" DNA-binding domain | 0.4102 | Inherited |
| Chromo domain-like | 0.4235 | Inherited |
| WD40 repeat-like | 0.4425 | Inherited |
| Nucleic acid-binding proteins | 0.4556 | Inherited |
| Histone-fold | 0.485 | Inherited |
| Metallo-dependent phosphatases | 0.5874 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.667 | Inherited |
| PLP-dependent transferases | 0.687 | Inherited |
| RNA-binding domain, RBD | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (SPWP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | DIRECT |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0.00000006049 | DIRECT |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.000008818 | DIRECT |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0.00002379 | DIRECT |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0.0001036 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.003982 | INHERITED FROM: accumulated germline cell corpses || programmed cell death variant || accumulated cell corpses || apoptosis variant |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.003982 | INHERITED FROM: accumulated germline cell corpses || programmed cell death variant || accumulated cell corpses || apoptosis variant |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.01243 | INHERITED FROM: cell corpse number variant || accumulated cell corpses |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01956 | INHERITED FROM: induced cell death variant || programmed cell death variant || non apoptotic cell death variant || radiation induced reproductive cell death variant |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.3825 | INHERITED FROM: accumulated germline cell corpses || cell corpse number variant || accumulated cell corpses |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.5199 | INHERITED FROM: starvation induced apoptosis variant |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | Direct |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0.00000006049 | Direct |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.000008818 | Direct |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0.00002379 | Direct |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0.0001036 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.003982 | Inherited |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.003982 | Inherited |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.01243 | Inherited |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01956 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.3825 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.5199 | Inherited |
(show details)
Supra-domains annotated to this WP term (SPWP level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.003982 | INHERITED FROM: accumulated germline cell corpses || programmed cell death variant || accumulated cell corpses || apoptosis variant |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.01243 | INHERITED FROM: cell corpse number variant || accumulated cell corpses || apoptosis variant |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.1367 | INHERITED FROM: accumulated germline cell corpses || accumulated cell corpses |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.003982 | Inherited |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.01243 | Inherited |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.1367 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
|
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
