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Worm Phenotype (WP): organism environmental stimulus response variant
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this WP term (SDWP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| HRDC-like | 0 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0.00000000000004464 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0.000000000001831 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.00000000005548 | DIRECT |
| Histone-fold | 0.0000000000687 | DIRECT |
| Periplasmic binding protein-like I | 0.0000000007659 | DIRECT |
| Nucleotide cyclase | 0.000000005567 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0.000000007216 | DIRECT |
| Skp1 dimerisation domain-like | 0.000001863 | DIRECT |
| GST C-terminal domain-like | 0.000004257 | DIRECT |
| Band 7/SPFH domain | 0.000006209 | DIRECT |
| DBL homology domain (DH-domain) | 0.00001329 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00002957 | DIRECT |
| GroEL-intermediate domain like | 0.00002957 | DIRECT |
| GroEL equatorial domain-like | 0.00002957 | DIRECT |
| Cullin repeat-like | 0.00002957 | DIRECT |
| Nucleotidylyl transferase | 0.00003301 | DIRECT |
| Class II aaRS and biotin synthetases | 0.00006297 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.00006557 | DIRECT |
| Tubulin C-terminal domain-like | 0.0001188 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.0002084 | DIRECT |
| GroEL apical domain-like | 0.0002084 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0.0003201 | DIRECT |
| Cullin homology domain | 0.0003578 | DIRECT |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.0006223 | DIRECT |
| DEATH domain | 0.0006493 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.0006493 | DIRECT |
| Calcium ATPase, transduction domain A | 0.0006986 | DIRECT |
| Protein kinase-like (PK-like) | 0.0007154 | DIRECT |
| Nucleic acid-binding proteins | 0.0008371 | DIRECT |
| Translation proteins SH3-like domain | 0.0008577 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.001223 | INHERITED FROM: cell gamma ray response variant || cell stress response variant || cell ionizing radiation response variant || organism ionizing radiation response variant || organism stress response variant || gamma ray induced apoptosis decreased || organism gamma ray response variant |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.001434 | INHERITED FROM: nicotine hypersensitive || drug hypersensitive |
| ABC transporter transmembrane region | 0.001618 | INHERITED FROM: colchicine hypersensitive || chemical hypersensitive || cadmium response variant || chemical response variant || metal response variant || cadmium hypersensitive |
| Actin-like ATPase domain | 0.001618 | INHERITED FROM: avoids bacterial lawn |
| PIN domain-like | 0.001977 | INHERITED FROM: organism stress response variant |
| S15/NS1 RNA-binding domain | 0.002244 | INHERITED FROM: avoids bacterial lawn || response to bacteria variant |
| Leucine zipper domain | 0.002394 | INHERITED FROM: pore forming toxin response variant || pathogen susceptibility increased |
| Calcium ATPase, transmembrane domain M | 0.002705 | INHERITED FROM: nicotine hypersensitive || drug hypersensitive |
| Hect, E3 ligase catalytic domain | 0.002894 | INHERITED FROM: germ cell ionizing radiation response variant || cell ionizing radiation response variant |
| Cysteine-rich domain | 0.003203 | INHERITED FROM: thermosensory behavior variant || odorant chemosensory response variant || odorant positive chemotaxis variant || positive chemotaxis variant || pathogen induced antimicrobial gene expression variant || bacterially unswollen || acetylcholinesterase inhibitor response variant || response to injury variant || thermotaxis variant || organism stress response variant || pathogen induced gene expression variant || aldicarb response variant |
| F1F0 ATP synthase subunit C | 0.004107 | INHERITED FROM: avoids bacterial lawn || organism stress response variant |
| ARID-like | 0.004107 | INHERITED FROM: organism UV hypersensitive || organism UV response variant || organism stress response variant |
| FYVE/PHD zinc finger | 0.00416 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
| Periplasmic binding protein-like II | 0.004602 | INHERITED FROM: aqueous positive chemotaxis defective || thermosensory behavior variant || positive chemotaxis defective || memory retention defective || sodium chloride chemotaxis defective || chemotaxis variant || thermotaxis variant || response to food variant || organism starvation response variant || aqueous positive chemotaxis variant || sodium chloride chemotaxis variant || chemosensory response variant |
| Glutathione synthetase ATP-binding domain-like | 0.004754 | INHERITED FROM: negative chemotaxis variant || osmotic avoidance variant || chemotaxis variant |
| Zn-binding ribosomal proteins | 0.005863 | INHERITED FROM: avoids bacterial lawn || response to bacteria variant |
| Insulin-like | 0.006174 | INHERITED FROM: temperature induced dauer formation variant |
| Ligand-binding domain in the NO signalling and Golgi transport | 0.007123 | INHERITED FROM: drug response variant || anesthetic response variant || carbon dioxide response variant || chemical response variant || carbon dioxide avoidance variant |
| Thioredoxin-like | 0.007297 | INHERITED FROM: paraquat response variant || organism electrophilic stress hypersensitive || organism toxic chemical response variant || organism heat hypersensitive || organism stress response variant || metal response variant |
| Di-copper centre-containing domain | 0.009643 | INHERITED FROM: cell stress response variant || germ cell ionizing radiation response variant || cell ionizing radiation response variant || organism ionizing radiation response variant |
| Sm-like ribonucleoproteins | 0.01013 | INHERITED FROM: organism heat response variant || unfolded protein response variant || avoids bacterial lawn || response to bacteria variant |
| cAMP-binding domain-like | 0.01061 | INHERITED FROM: thermosensory behavior variant || odorant chemosensory response variant || odorant negative chemotaxis defective || odorant positive chemotaxis variant || benzaldehyde chemotaxis defective || positive chemotaxis defective || positive chemotaxis variant || carbon dioxide response variant || butanone chemotaxis variant || sodium chloride chemotaxis defective || chemotaxis variant || odorant positive chemotaxis defective || thermotaxis variant || chemical response variant || organism temperature response variant || carbon dioxide avoidance variant || benzaldehyde chemotaxis variant || sodium chloride chemotaxis variant |
| DNA/RNA polymerases | 0.01089 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
| Aquaporin-like | 0.01471 | INHERITED FROM: organism stress response variant || organism osmotic stress response variant |
| PH domain-like | 0.01518 | INHERITED FROM: conflicting sensory integration variant || pathogen resistance increased || bacterially unswollen || response to injury variant || organism pathogen response variant || cellular osmotic stress response variant || aldicarb response variant |
| Class II aaRS ABD-related | 0.01639 | INHERITED FROM: oxygen response variant || hypoxia response variant || avoids bacterial lawn || organism stress response variant || hypoxia resistant || response to bacteria variant |
| Troponin coil-coiled subunits | 0.01639 | INHERITED FROM: nicotine response variant || drug response variant |
| "Winged helix" DNA-binding domain | 0.01926 | INHERITED FROM: anesthetic response variant |
| TPR-like | 0.01935 | INHERITED FROM: antihelmintic response variant || light body touch resistant || positive chemotaxis defective || chemotaxis variant || ivermectin resistant || ivermectin response variant |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.02135 | INHERITED FROM: stress induced lethality variant || stress induced lethality increased || avoids bacterial lawn || organism hypertonic lethality increased || organism osmotic stress response variant || response to bacteria variant |
| WW domain | 0.02222 | INHERITED FROM: aldicarb resistant |
| HSP20-like chaperones | 0.0236 | INHERITED FROM: cadmium response variant || pathogen susceptibility increased || cadmium hypersensitive |
| SH3-domain | 0.02718 | INHERITED FROM: aldicarb response variant |
| Spectrin repeat | 0.02894 | INHERITED FROM: drug response variant || aldicarb response variant |
| L30e-like | 0.03513 | INHERITED FROM: avoids bacterial lawn |
| HD-domain/PDEase-like | 0.03587 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant || organism temperature response variant |
| NAD kinase/diacylglycerol kinase-like | 0.03587 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant |
| Bromodomain | 0.03969 | INHERITED FROM: anesthetic resistant || organism UV hypersensitive || drug adaptation variant || ethanol resistant || anesthetic response variant || acute functional tolerance to alcohol defective || organism UV response variant |
| Ankyrin repeat | 0.04065 | INHERITED FROM: odorant negative chemotaxis defective || organism heat response variant || chemotaxis variant || octanol chemotaxis variant || octanol chemotaxis defective || chemosensory response variant |
| HAD-like | 0.04084 | INHERITED FROM: nicotine hypersensitive |
| WD40 repeat-like | 0.04991 | INHERITED FROM: osmotic avoidance variant || pathogen induced antimicrobial gene expression variant || aldicarb response variant |
| PLC-like phosphodiesterases | 0.07869 | INHERITED FROM: cell stress response variant || response to injury variant || organism pathogen response variant || cellular osmotic stress response variant || organism osmotic stress response variant |
| PYP-like sensor domain (PAS domain) | 0.07959 | INHERITED FROM: oxygen response variant || hypoxia response variant || anesthetic response variant || carbon dioxide response variant || hypoxia hypersensitive || carbon dioxide avoidance variant |
| Myosin rod fragments | 0.08324 | INHERITED FROM: drug resistant |
| HLH, helix-loop-helix DNA-binding domain | 0.09022 | INHERITED FROM: aqueous positive chemotaxis defective || fungal resistance increased || pathogen resistance increased || hypoxia response variant || lysine chemotaxis defective |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.09929 | INHERITED FROM: pesticide response variant || paraquat response variant || organism toxic chemical response variant || organism oxidative stress response variant |
| Cation efflux protein cytoplasmic domain-like | 0.09929 | INHERITED FROM: chemical hypersensitive || cadmium response variant || metal response variant || cadmium hypersensitive |
| Cation efflux protein transmembrane domain-like | 0.1007 | INHERITED FROM: manganese toxicity resistant || metal response variant || cadmium hypersensitive || manganese response variant |
| Saposin | 0.1095 | INHERITED FROM: germ cell ionizing radiation response variant || germ cell resistant ionizing radiation || pathogen load variant || radiation induced germ cell apoptosis variant || increased pathogen survival |
| PLP-dependent transferases | 0.1165 | INHERITED FROM: germ cell resistant ionizing radiation || radiation induced germ cell apoptosis variant |
| SNF-like | 0.1252 | INHERITED FROM: drug hypersensitive |
| Regulator of G-protein signaling, RGS | 0.1299 | INHERITED FROM: negative chemotaxis variant || chemotaxis variant || mechanosensation variant |
| Arginase/deacetylase | 0.1302 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
| t-snare proteins | 0.1302 | INHERITED FROM: drug hypersensitive |
| Voltage-gated potassium channels | 0.1367 | INHERITED FROM: serotonin response variant || positive chemotaxis defective || serotonin resistant || phentolamine resistant || adrenergic receptor antagonist response variant || mechanosensation variant || imipramine resistant |
| Multidrug efflux transporter AcrB transmembrane domain | 0.1669 | INHERITED FROM: odorant chemosensory response variant || positive chemotaxis defective || chemotaxis variant || odorant positive chemotaxis defective |
| ACP-like | 0.1686 | INHERITED FROM: organism starvation response variant |
| EF-hand | 0.1873 | INHERITED FROM: cellular osmotic stress response variant || aldicarb response variant |
| Heme-dependent peroxidases | 0.2019 | INHERITED FROM: pathogen susceptibility increased |
| Immunoglobulin | 0.22 | INHERITED FROM: aldicarb response variant |
| Homeodomain-like | 0.2385 | INHERITED FROM: carbon dioxide response variant || phentolamine resistant || adrenergic receptor antagonist response variant || carbon dioxide avoidance variant || imipramine resistant || egg laying imipramine resistant |
| PRTase-like | 0.2484 | INHERITED FROM: Fluorouracil resistant || drug resistant |
| SAM/Pointed domain | 0.2533 | INHERITED FROM: aldicarb response variant |
| HMG-box | 0.2603 | INHERITED FROM: anesthetic response variant |
| Multidrug resistance efflux transporter EmrE | 0.272 | INHERITED FROM: pathogen resistance increased || bacterially unswollen || response to bacteria variant |
| Lipocalins | 0.3012 | INHERITED FROM: paraquat hypersensitive |
| Quinoprotein alcohol dehydrogenase-like | 0.3177 | INHERITED FROM: hypoxia response variant |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.3339 | INHERITED FROM: avoids bacterial lawn || response to bacteria variant |
| Cytochrome P450 | 0.4007 | INHERITED FROM: cadmium response variant || metal response variant || cadmium hypersensitive |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0.4045 | INHERITED FROM: drug hypersensitive |
| SNARE-like | 0.4045 | INHERITED FROM: acetylcholinesterase inhibitor resistant || aldicarb resistant |
| RING/U-box | 0.4159 | INHERITED FROM: cell stress response variant || germ cell ionizing radiation response variant || germ cell hypersensitive ionizing radiation || cell ionizing radiation response variant || organism ionizing radiation response variant |
| Chromo domain-like | 0.4336 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
| ENTH/VHS domain | 0.4771 | INHERITED FROM: acetylcholinesterase inhibitor resistant || aldicarb resistant |
| FAD/NAD(P)-binding domain | 0.5525 | INHERITED FROM: pesticide response variant || organism toxic chemical response variant || organism oxidative stress response variant |
| Cystine-knot cytokines | 0.6107 | INHERITED FROM: nicotine response variant || levamisole response variant |
| EGF/Laminin | 0.6851 | INHERITED FROM: odorant negative chemotaxis defective || octanol chemotaxis variant || octanol chemotaxis defective |
| Metallo-dependent phosphatases | 0.7057 | INHERITED FROM: germ cell resistant ionizing radiation || radiation induced germ cell apoptosis variant |
| Nucleotide-diphospho-sugar transferases | 0.7404 | INHERITED FROM: resistant to lectin || lectin response variant |
| RNA-binding domain, RBD | 0.7615 | INHERITED FROM: innate immune response variant || starvation induced apoptosis variant || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant |
| Cysteine proteinases | 0.7697 | INHERITED FROM: paraquat hypersensitive |
| PDZ domain-like | 0.7837 | INHERITED FROM: chemical resistant || drug resistant || acetylcholinesterase inhibitor response variant || aldicarb response variant |
| (Trans)glycosidases | 0.7954 | INHERITED FROM: pathogen susceptibility increased |
| Glucocorticoid receptor-like (DNA-binding domain) | 1 | INHERITED FROM: SDS sensitive dauer |
| beta-beta-alpha zinc fingers | 1 | INHERITED FROM: inhibitor of serotonin uptake variant || imipramine resistant || egg laying imipramine resistant |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: locomotion rate serotonin variant || serotonin induced pumping variant || male tail curling serotonin variant || serotonin induced fat reduction variant |
| Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: SDS sensitive dauer |
| MFS general substrate transporter | 1 | INHERITED FROM: organism high sodium chloride hypersensitive |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: gamma ray induced apoptosis increased || cell gamma ray response variant || organism gamma ray response variant |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Cytochrome c | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| LEM domain | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| HRDC-like | 0 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0.00000000000004464 | Direct |
| Transducin (alpha subunit), insertion domain | 0.000000000001831 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.00000000005548 | Direct |
| Histone-fold | 0.0000000000687 | Direct |
| Periplasmic binding protein-like I | 0.0000000007659 | Direct |
| Nucleotide cyclase | 0.000000005567 | Direct |
| Nicotinic receptor ligand binding domain-like | 0.000000007216 | Direct |
| Skp1 dimerisation domain-like | 0.000001863 | Direct |
| GST C-terminal domain-like | 0.000004257 | Direct |
| Band 7/SPFH domain | 0.000006209 | Direct |
| DBL homology domain (DH-domain) | 0.00001329 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00002957 | Direct |
| GroEL-intermediate domain like | 0.00002957 | Direct |
| GroEL equatorial domain-like | 0.00002957 | Direct |
| Cullin repeat-like | 0.00002957 | Direct |
| Nucleotidylyl transferase | 0.00003301 | Direct |
| Class II aaRS and biotin synthetases | 0.00006297 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.00006557 | Direct |
| Tubulin C-terminal domain-like | 0.0001188 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.0002084 | Direct |
| GroEL apical domain-like | 0.0002084 | Direct |
| Tubulin nucleotide-binding domain-like | 0.0003201 | Direct |
| Cullin homology domain | 0.0003578 | Direct |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.0006223 | Direct |
| DEATH domain | 0.0006493 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.0006493 | Direct |
| Calcium ATPase, transduction domain A | 0.0006986 | Direct |
| Protein kinase-like (PK-like) | 0.0007154 | Direct |
| Nucleic acid-binding proteins | 0.0008371 | Direct |
| Translation proteins SH3-like domain | 0.0008577 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.001223 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.001434 | Inherited |
| ABC transporter transmembrane region | 0.001618 | Inherited |
| Actin-like ATPase domain | 0.001618 | Inherited |
| PIN domain-like | 0.001977 | Inherited |
| S15/NS1 RNA-binding domain | 0.002244 | Inherited |
| Leucine zipper domain | 0.002394 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.002705 | Inherited |
| Hect, E3 ligase catalytic domain | 0.002894 | Inherited |
| Cysteine-rich domain | 0.003203 | Inherited |
| F1F0 ATP synthase subunit C | 0.004107 | Inherited |
| ARID-like | 0.004107 | Inherited |
| FYVE/PHD zinc finger | 0.00416 | Inherited |
| Periplasmic binding protein-like II | 0.004602 | Inherited |
| Glutathione synthetase ATP-binding domain-like | 0.004754 | Inherited |
| Zn-binding ribosomal proteins | 0.005863 | Inherited |
| Insulin-like | 0.006174 | Inherited |
| Ligand-binding domain in the NO signalling and Golgi transport | 0.007123 | Inherited |
| Thioredoxin-like | 0.007297 | Inherited |
| Di-copper centre-containing domain | 0.009643 | Inherited |
| Sm-like ribonucleoproteins | 0.01013 | Inherited |
| cAMP-binding domain-like | 0.01061 | Inherited |
| DNA/RNA polymerases | 0.01089 | Inherited |
| Aquaporin-like | 0.01471 | Inherited |
| PH domain-like | 0.01518 | Inherited |
| Class II aaRS ABD-related | 0.01639 | Inherited |
| Troponin coil-coiled subunits | 0.01639 | Inherited |
| "Winged helix" DNA-binding domain | 0.01926 | Inherited |
| TPR-like | 0.01935 | Inherited |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.02135 | Inherited |
| WW domain | 0.02222 | Inherited |
| HSP20-like chaperones | 0.0236 | Inherited |
| SH3-domain | 0.02718 | Inherited |
| Spectrin repeat | 0.02894 | Inherited |
| L30e-like | 0.03513 | Inherited |
| HD-domain/PDEase-like | 0.03587 | Inherited |
| NAD kinase/diacylglycerol kinase-like | 0.03587 | Inherited |
| Bromodomain | 0.03969 | Inherited |
| Ankyrin repeat | 0.04065 | Inherited |
| HAD-like | 0.04084 | Inherited |
| WD40 repeat-like | 0.04991 | Inherited |
| PLC-like phosphodiesterases | 0.07869 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.07959 | Inherited |
| Myosin rod fragments | 0.08324 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.09022 | Inherited |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.09929 | Inherited |
| Cation efflux protein cytoplasmic domain-like | 0.09929 | Inherited |
| Cation efflux protein transmembrane domain-like | 0.1007 | Inherited |
| Saposin | 0.1095 | Inherited |
| PLP-dependent transferases | 0.1165 | Inherited |
| SNF-like | 0.1252 | Inherited |
| Regulator of G-protein signaling, RGS | 0.1299 | Inherited |
| Arginase/deacetylase | 0.1302 | Inherited |
| t-snare proteins | 0.1302 | Inherited |
| Voltage-gated potassium channels | 0.1367 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.1669 | Inherited |
| ACP-like | 0.1686 | Inherited |
| EF-hand | 0.1873 | Inherited |
| Heme-dependent peroxidases | 0.2019 | Inherited |
| Immunoglobulin | 0.22 | Inherited |
| Homeodomain-like | 0.2385 | Inherited |
| PRTase-like | 0.2484 | Inherited |
| SAM/Pointed domain | 0.2533 | Inherited |
| HMG-box | 0.2603 | Inherited |
| Multidrug resistance efflux transporter EmrE | 0.272 | Inherited |
| Lipocalins | 0.3012 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.3177 | Inherited |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.3339 | Inherited |
| Cytochrome P450 | 0.4007 | Inherited |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0.4045 | Inherited |
| SNARE-like | 0.4045 | Inherited |
| RING/U-box | 0.4159 | Inherited |
| Chromo domain-like | 0.4336 | Inherited |
| ENTH/VHS domain | 0.4771 | Inherited |
| FAD/NAD(P)-binding domain | 0.5525 | Inherited |
| Cystine-knot cytokines | 0.6107 | Inherited |
| EGF/Laminin | 0.6851 | Inherited |
| Metallo-dependent phosphatases | 0.7057 | Inherited |
| Nucleotide-diphospho-sugar transferases | 0.7404 | Inherited |
| RNA-binding domain, RBD | 0.7615 | Inherited |
| Cysteine proteinases | 0.7697 | Inherited |
| PDZ domain-like | 0.7837 | Inherited |
| (Trans)glycosidases | 0.7954 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 1 | Inherited |
| beta-beta-alpha zinc fingers | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
| Nuclear receptor ligand-binding domain | 1 | Inherited |
| MFS general substrate transporter | 1 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this WP term (SDWP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| a tRNA synthase domain | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
| Heme-dependent catalases | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| XPF/Rad1/Mus81 nuclease | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| SCF ubiquitin ligase complex WHB domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| RNA-polymerase beta | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Mammalian PLC | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| DEATH domain, DD | 0 | DIRECT |
| Trunk domain of Sec23/24 | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| 5' to 3' exonuclease catalytic domain | 0 | DIRECT |
| RecA protein-like (ATPase-domain) | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Arginine methyltransferase | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0.00000000004087 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.000000001567 | DIRECT |
| Nucleosome core histones | 0.00000002262 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0.00000007461 | DIRECT |
| L-arabinose binding protein-like | 0.00000007622 | DIRECT |
| Adenylyl and guanylyl cyclase catalytic domain | 0.0000002096 | DIRECT |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.0000004513 | DIRECT |
| G proteins | 0.000005452 | DIRECT |
| Proteasome subunits | 0.000009659 | DIRECT |
| Skp1 dimerisation domain-like | 0.00003664 | DIRECT |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.00004903 | DIRECT |
| Pleckstrin-homology domain (PH domain) | 0.00005522 | DIRECT |
| DBL homology domain (DH-domain) | 0.00007065 | DIRECT |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.00007065 | DIRECT |
| Band 7/SPFH domain | 0.00008716 | DIRECT |
| Meta-cation ATPase, catalytic domain P | 0.000108 | DIRECT |
| PHD domain | 0.0001429 | DIRECT |
| PLC-like (P variant) | 0.0002123 | DIRECT |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.0002614 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0002614 | DIRECT |
| Tubulin, C-terminal domain | 0.0005102 | DIRECT |
| Calcium ATPase, transmembrane domain M | 0.0005805 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.0005805 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.0005805 | DIRECT |
| Cullin homology domain | 0.0007797 | DIRECT |
| Tubulin, GTPase domain | 0.001184 | INHERITED FROM: nose touch variant || nicotine response variant || avoids bacterial lawn || mechanosensation variant || touch resistant |
| Actin/HSP70 | 0.001188 | INHERITED FROM: cadmium response variant || avoids bacterial lawn |
| Tandem AAA-ATPase domain | 0.00126 | INHERITED FROM: cell stress response variant || organism UV response variant || organism stress response variant |
| Glutathione S-transferase (GST), N-terminal domain | 0.001404 | INHERITED FROM: chemical hypersensitive || paraquat response variant || organism electrophilic stress hypersensitive || organism toxic chemical response variant || organism heat hypersensitive || organism stress response variant || metal response variant |
| Group II chaperonin (CCT, TRIC), apical domain | 0.001564 | INHERITED FROM: innate immune response variant || no induction of antimicrobial peptide expression after infection || organism heat response variant || pathogen induced antimicrobial gene expression variant || unfolded protein response variant || avoids bacterial lawn || response to bacteria variant |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.001564 | INHERITED FROM: organism stress response variant |
| PDEase | 0.002312 | INHERITED FROM: thermosensory behavior variant || thermotaxis variant || organism temperature response variant |
| Phosphate binding protein-like | 0.002516 | INHERITED FROM: aqueous positive chemotaxis defective || thermosensory behavior variant || positive chemotaxis defective || memory retention defective || sodium chloride chemotaxis defective || chemotaxis variant || thermotaxis variant || response to food variant || organism starvation response variant || aqueous positive chemotaxis variant || sodium chloride chemotaxis variant || chemosensory response variant |
| Calcium ATPase, transduction domain A | 0.002689 | INHERITED FROM: nicotine hypersensitive || drug hypersensitive |
| Glutathione S-transferase (GST), C-terminal domain | 0.003192 | INHERITED FROM: organism electrophilic stress hypersensitive || organism heat hypersensitive || organism stress response variant || metal response variant || cadmium hypersensitive |
| I set domains | 0.003776 | INHERITED FROM: aldicarb response variant |
| EF-hand modules in multidomain proteins | 0.003947 | INHERITED FROM: cell stress response variant |
| Aquaporin-like | 0.004157 | INHERITED FROM: organism stress response variant || organism osmotic stress response variant |
| ABC transporter transmembrane region | 0.004631 | INHERITED FROM: colchicine hypersensitive || chemical hypersensitive || cadmium response variant || metal response variant || cadmium hypersensitive |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.005601 | INHERITED FROM: thermosensory behavior variant || nose touch variant || chemical resistant || odorant positive chemotaxis variant || pathogen induced antimicrobial gene expression variant || drug resistant || response to injury variant || thermotaxis variant || organism temperature response variant || organism stress response variant || pathogen induced gene expression variant || aldicarb response variant |
| Hect, E3 ligase catalytic domain | 0.006395 | INHERITED FROM: germ cell ionizing radiation response variant || cell ionizing radiation response variant |
| Pyridoxal-dependent decarboxylase | 0.006395 | INHERITED FROM: carbon dioxide response variant || egg laying response to drug variant || carbon dioxide avoidance variant |
| ARID domain | 0.006782 | INHERITED FROM: organism UV hypersensitive || organism UV response variant || organism stress response variant |
| L30e/L7ae ribosomal proteins | 0.006782 | INHERITED FROM: avoids bacterial lawn |
| F1F0 ATP synthase subunit C | 0.006782 | INHERITED FROM: avoids bacterial lawn || organism stress response variant |
| Leucine zipper domain | 0.009245 | INHERITED FROM: pore forming toxin response variant || pathogen susceptibility increased |
| Erythroid transcription factor GATA-1 | 0.01263 | INHERITED FROM: paraquat response variant || organism toxic chemical response variant || organism stress response variant |
| H-NOX domain | 0.01285 | INHERITED FROM: drug response variant || anesthetic response variant || carbon dioxide response variant || carbon dioxide avoidance variant |
| Hemocyanin middle domain | 0.01285 | INHERITED FROM: cell stress response variant || germ cell ionizing radiation response variant || cell ionizing radiation response variant || organism ionizing radiation response variant |
| cAMP-binding domain | 0.0129 | INHERITED FROM: thermosensory behavior variant || odorant chemosensory response variant || odorant negative chemotaxis defective || odorant positive chemotaxis variant || benzaldehyde chemotaxis defective || positive chemotaxis defective || positive chemotaxis variant || carbon dioxide response variant || butanone chemotaxis variant || sodium chloride chemotaxis defective || chemotaxis variant || odorant positive chemotaxis defective || thermotaxis variant || chemical response variant || organism temperature response variant || carbon dioxide avoidance variant || benzaldehyde chemotaxis variant || sodium chloride chemotaxis variant |
| Anticodon-binding domain | 0.01977 | INHERITED FROM: avoids bacterial lawn || response to bacteria variant |
| Eps15 homology domain (EH domain) | 0.01977 | INHERITED FROM: drug response variant || acetylcholinesterase inhibitor response variant || aldicarb response variant |
| Insulin-like | 0.02179 | INHERITED FROM: temperature induced dauer formation variant |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.0271 | INHERITED FROM: avoids bacterial lawn || response to bacteria variant |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.02739 | INHERITED FROM: hydroxyurea response variant || drug hypersensitive || hydroxyurea hypersensitive |
| Spectrin repeat | 0.02885 | INHERITED FROM: drug response variant || aldicarb response variant |
| Transforming growth factor (TGF)-beta | 0.04547 | INHERITED FROM: nicotine response variant || drug response variant || levamisole response variant |
| Cation efflux protein cytoplasmic domain-like | 0.06697 | INHERITED FROM: chemical hypersensitive || cadmium response variant || metal response variant || cadmium hypersensitive |
| Bromodomain | 0.07839 | INHERITED FROM: anesthetic resistant || organism UV hypersensitive || drug adaptation variant || ethanol resistant || anesthetic response variant || acute functional tolerance to alcohol defective || organism UV response variant |
| Extended AAA-ATPase domain | 0.07909 | INHERITED FROM: response to bacteria variant |
| Protein kinases, catalytic subunit | 0.07965 | INHERITED FROM: colchicine resistant || copper hypersensitive || conflicting sensory integration variant || oxygen response variant || egg laying response to food variant || hypoxia response variant || alkaline pH chemotaxis variant || positive chemotaxis variant || anoxia response variant || anoxia resistant || chemical response variant || mechanosensation variant || metal response variant || octanol chemotaxis defective || aldicarb response variant |
| Fatty acid binding protein-like | 0.09086 | INHERITED FROM: paraquat hypersensitive || paraquat response variant || organism toxic chemical response variant |
| Armadillo repeat | 0.09086 | INHERITED FROM: innate immune response variant || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant |
| Synaptotagmin-like (S variant) | 0.09554 | INHERITED FROM: chemical resistant || drug response variant || acetylcholinesterase inhibitor resistant || drug resistant || acetylcholinesterase inhibitor response variant |
| SH3-domain | 0.118 | INHERITED FROM: aldicarb response variant |
| HSP20 | 0.1216 | INHERITED FROM: pathogen susceptibility increased || organism pathogen response variant |
| Histone deacetylase, HDAC | 0.1216 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
| ABC transporter ATPase domain-like | 0.1332 | INHERITED FROM: colchicine hypersensitive || chemical hypersensitive || cadmium response variant || metal response variant || cadmium hypersensitive |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.1374 | INHERITED FROM: pesticide response variant || paraquat response variant || organism toxic chemical response variant || organism oxidative stress response variant |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.1394 | INHERITED FROM: pesticide response variant || paraquat response variant || organism toxic chemical response variant || organism oxidative stress response variant |
| SNF-like | 0.1659 | INHERITED FROM: drug hypersensitive |
| Ankyrin repeat | 0.1676 | INHERITED FROM: odorant negative chemotaxis defective || organism heat response variant || octanol chemotaxis variant || octanol chemotaxis defective |
| t-snare proteins | 0.1933 | INHERITED FROM: drug hypersensitive |
| Cation efflux protein transmembrane domain-like | 0.1947 | INHERITED FROM: chemical hypersensitive || cadmium response variant || manganese toxicity resistant || metal response variant || cadmium hypersensitive || manganese response variant |
| HLH, helix-loop-helix DNA-binding domain | 0.2223 | INHERITED FROM: aqueous positive chemotaxis defective || fungal resistance increased || pathogen resistance increased || lysine chemotaxis defective |
| Phosphoribosyltransferases (PRTases) | 0.2308 | INHERITED FROM: chemical resistant || Fluorouracil resistant || drug resistant |
| Clathrin coat assembly domain | 0.2308 | INHERITED FROM: chemical resistant || acetylcholinesterase inhibitor resistant || drug resistant || aldicarb resistant || acetylcholinesterase inhibitor response variant || aldicarb response variant |
| WD40-repeat | 0.2371 | INHERITED FROM: osmotic avoidance variant || pathogen induced antimicrobial gene expression variant || ivermectin resistant || ivermectin response variant |
| Regulator of G-protein signaling, RGS | 0.2376 | INHERITED FROM: negative chemotaxis variant || chemotaxis variant || mechanosensation variant |
| RING finger domain, C3HC4 | 0.2813 | INHERITED FROM: germ cell ionizing radiation response variant || germ cell hypersensitive ionizing radiation |
| PDZ domain | 0.2879 | INHERITED FROM: chemical resistant || egg laying serotonin variant || aldicarb response variant |
| Myeloperoxidase-like | 0.3045 | INHERITED FROM: pathogen susceptibility increased |
| Multidrug efflux transporter AcrB transmembrane domain | 0.3182 | INHERITED FROM: odorant chemosensory response variant || positive chemotaxis defective || chemotaxis variant || odorant positive chemotaxis defective |
| Homeodomain | 0.3529 | INHERITED FROM: anesthetic response variant || carbon dioxide response variant || carbon dioxide avoidance variant |
| HMG-box | 0.3957 | INHERITED FROM: anesthetic response variant |
| BTB/POZ domain | 0.4458 | INHERITED FROM: chemical hypersensitive |
| Motor proteins | 0.4809 | INHERITED FROM: sexually dimorphic mechanosensation variant || male response to hermaphrodite variant |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0.5339 | INHERITED FROM: drug hypersensitive |
| Chromo domain | 0.5339 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
| Glutathione peroxidase-like | 0.6824 | INHERITED FROM: paraquat hypersensitive || pesticide response variant || paraquat response variant || organism toxic chemical response variant |
| Cytochrome P450 | 0.7225 | INHERITED FROM: cadmium response variant || metal response variant || cadmium hypersensitive |
| Voltage-gated potassium channels | 0.7834 | INHERITED FROM: serotonin response variant || serotonin resistant || phentolamine resistant || adrenergic receptor antagonist response variant |
| Rhodopsin-like | 0.9182 | INHERITED FROM: serotonin response variant || locomotion rate serotonin variant || serotonin induced pumping variant || male tail curling serotonin variant || serotonin resistant || biogenic amine receptor antagonist resistant || egg laying response to drug variant || methiothepin resistant || organism pathogen response variant || serotonin hypersensitive || cyproheptadine resistant || mianserin resistant || aqueous adaptation defective || serotonin induced fat reduction variant || drug withdrawal response variant |
| Canonical RBD | 0.9329 | INHERITED FROM: innate immune response variant || starvation induced apoptosis variant || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant |
| Nuclear receptor | 1 | INHERITED FROM: SDS sensitive dauer |
| Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: SDS sensitive dauer |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| a tRNA synthase domain | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
| Heme-dependent catalases | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| Cullin repeat | 0 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| XPF/Rad1/Mus81 nuclease | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| SCF ubiquitin ligase complex WHB domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| RNA-polymerase beta | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Mammalian PLC | 0 | Direct |
| LEM domain | 0 | Direct |
| DEATH domain, DD | 0 | Direct |
| Trunk domain of Sec23/24 | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| 5' to 3' exonuclease catalytic domain | 0 | Direct |
| RecA protein-like (ATPase-domain) | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Arginine methyltransferase | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0.00000000004087 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.000000001567 | Direct |
| Nucleosome core histones | 0.00000002262 | Direct |
| Nicotinic receptor ligand binding domain-like | 0.00000007461 | Direct |
| L-arabinose binding protein-like | 0.00000007622 | Direct |
| Adenylyl and guanylyl cyclase catalytic domain | 0.0000002096 | Direct |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.0000004513 | Direct |
| G proteins | 0.000005452 | Direct |
| Proteasome subunits | 0.000009659 | Direct |
| Skp1 dimerisation domain-like | 0.00003664 | Direct |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.00004903 | Direct |
| Pleckstrin-homology domain (PH domain) | 0.00005522 | Direct |
| DBL homology domain (DH-domain) | 0.00007065 | Direct |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.00007065 | Direct |
| Band 7/SPFH domain | 0.00008716 | Direct |
| Meta-cation ATPase, catalytic domain P | 0.000108 | Direct |
| PHD domain | 0.0001429 | Direct |
| PLC-like (P variant) | 0.0002123 | Direct |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.0002614 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0002614 | Direct |
| Tubulin, C-terminal domain | 0.0005102 | Direct |
| Calcium ATPase, transmembrane domain M | 0.0005805 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.0005805 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.0005805 | Direct |
| Cullin homology domain | 0.0007797 | Direct |
| Tubulin, GTPase domain | 0.001184 | Inherited |
| Actin/HSP70 | 0.001188 | Inherited |
| Tandem AAA-ATPase domain | 0.00126 | Inherited |
| Glutathione S-transferase (GST), N-terminal domain | 0.001404 | Inherited |
| Group II chaperonin (CCT, TRIC), apical domain | 0.001564 | Inherited |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.001564 | Inherited |
| PDEase | 0.002312 | Inherited |
| Phosphate binding protein-like | 0.002516 | Inherited |
| Calcium ATPase, transduction domain A | 0.002689 | Inherited |
| Glutathione S-transferase (GST), C-terminal domain | 0.003192 | Inherited |
| I set domains | 0.003776 | Inherited |
| EF-hand modules in multidomain proteins | 0.003947 | Inherited |
| Aquaporin-like | 0.004157 | Inherited |
| ABC transporter transmembrane region | 0.004631 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.005601 | Inherited |
| Hect, E3 ligase catalytic domain | 0.006395 | Inherited |
| Pyridoxal-dependent decarboxylase | 0.006395 | Inherited |
| ARID domain | 0.006782 | Inherited |
| L30e/L7ae ribosomal proteins | 0.006782 | Inherited |
| F1F0 ATP synthase subunit C | 0.006782 | Inherited |
| Leucine zipper domain | 0.009245 | Inherited |
| Erythroid transcription factor GATA-1 | 0.01263 | Inherited |
| H-NOX domain | 0.01285 | Inherited |
| Hemocyanin middle domain | 0.01285 | Inherited |
| cAMP-binding domain | 0.0129 | Inherited |
| Anticodon-binding domain | 0.01977 | Inherited |
| Eps15 homology domain (EH domain) | 0.01977 | Inherited |
| Insulin-like | 0.02179 | Inherited |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.0271 | Inherited |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.02739 | Inherited |
| Spectrin repeat | 0.02885 | Inherited |
| Transforming growth factor (TGF)-beta | 0.04547 | Inherited |
| Cation efflux protein cytoplasmic domain-like | 0.06697 | Inherited |
| Bromodomain | 0.07839 | Inherited |
| Extended AAA-ATPase domain | 0.07909 | Inherited |
| Protein kinases, catalytic subunit | 0.07965 | Inherited |
| Fatty acid binding protein-like | 0.09086 | Inherited |
| Armadillo repeat | 0.09086 | Inherited |
| Synaptotagmin-like (S variant) | 0.09554 | Inherited |
| SH3-domain | 0.118 | Inherited |
| HSP20 | 0.1216 | Inherited |
| Histone deacetylase, HDAC | 0.1216 | Inherited |
| ABC transporter ATPase domain-like | 0.1332 | Inherited |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.1374 | Inherited |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.1394 | Inherited |
| SNF-like | 0.1659 | Inherited |
| Ankyrin repeat | 0.1676 | Inherited |
| t-snare proteins | 0.1933 | Inherited |
| Cation efflux protein transmembrane domain-like | 0.1947 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.2223 | Inherited |
| Phosphoribosyltransferases (PRTases) | 0.2308 | Inherited |
| Clathrin coat assembly domain | 0.2308 | Inherited |
| WD40-repeat | 0.2371 | Inherited |
| Regulator of G-protein signaling, RGS | 0.2376 | Inherited |
| RING finger domain, C3HC4 | 0.2813 | Inherited |
| PDZ domain | 0.2879 | Inherited |
| Myeloperoxidase-like | 0.3045 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.3182 | Inherited |
| Homeodomain | 0.3529 | Inherited |
| HMG-box | 0.3957 | Inherited |
| BTB/POZ domain | 0.4458 | Inherited |
| Motor proteins | 0.4809 | Inherited |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0.5339 | Inherited |
| Chromo domain | 0.5339 | Inherited |
| Glutathione peroxidase-like | 0.6824 | Inherited |
| Cytochrome P450 | 0.7225 | Inherited |
| Voltage-gated potassium channels | 0.7834 | Inherited |
| Rhodopsin-like | 0.9182 | Inherited |
| Canonical RBD | 0.9329 | Inherited |
| Nuclear receptor | 1 | Inherited |
| Nuclear receptor ligand-binding domain | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Heme-dependent catalase-like | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Cytochrome c | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| HRDC-like | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0.00000000000003503 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0.000000000001442 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.00000000004387 | DIRECT |
| Histone-fold | 0.00000000005434 | DIRECT |
| Periplasmic binding protein-like I | 0.000000000608 | DIRECT |
| Nucleotide cyclase | 0.000000004435 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0.000000005752 | DIRECT |
| Skp1 dimerisation domain-like | 0.000001509 | DIRECT |
| GST C-terminal domain-like | 0.000003458 | DIRECT |
| Band 7/SPFH domain | 0.000005048 | DIRECT |
| DBL homology domain (DH-domain) | 0.00001083 | DIRECT |
| GroEL equatorial domain-like | 0.00002414 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00002414 | DIRECT |
| GroEL-intermediate domain like | 0.00002414 | DIRECT |
| Cullin repeat-like | 0.00002414 | DIRECT |
| Nucleotidylyl transferase | 0.00002695 | DIRECT |
| Class II aaRS and biotin synthetases | 0.00005151 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.00005362 | DIRECT |
| Tubulin C-terminal domain-like | 0.00009744 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.0001712 | DIRECT |
| GroEL apical domain-like | 0.0001712 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0.0002638 | DIRECT |
| Cullin homology domain | 0.000295 | DIRECT |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.0005158 | DIRECT |
| DEATH domain | 0.0005382 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.0005382 | DIRECT |
| Calcium ATPase, transduction domain A | 0.0005796 | DIRECT |
| Protein kinase-like (PK-like) | 0.0005938 | DIRECT |
| Nucleic acid-binding proteins | 0.0006963 | DIRECT |
| Translation proteins SH3-like domain | 0.0007135 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.00102 | INHERITED FROM: gamma ray induced apoptosis decreased || cell ionizing radiation response variant || cell stress response variant || organism stress response variant || organism gamma ray response variant || organism ionizing radiation response variant || cell gamma ray response variant |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.001198 | INHERITED FROM: drug hypersensitive || nicotine hypersensitive |
| ABC transporter transmembrane region | 0.001352 | INHERITED FROM: metal response variant || cadmium hypersensitive || chemical response variant || chemical hypersensitive || colchicine hypersensitive || cadmium response variant |
| Actin-like ATPase domain | 0.001352 | INHERITED FROM: avoids bacterial lawn |
| PIN domain-like | 0.001658 | INHERITED FROM: organism stress response variant |
| S15/NS1 RNA-binding domain | 0.001886 | INHERITED FROM: response to bacteria variant || avoids bacterial lawn |
| Leucine zipper domain | 0.002014 | INHERITED FROM: pathogen susceptibility increased || pore forming toxin response variant |
| Calcium ATPase, transmembrane domain M | 0.00228 | INHERITED FROM: drug hypersensitive || nicotine hypersensitive |
| Hect, E3 ligase catalytic domain | 0.002441 | INHERITED FROM: germ cell ionizing radiation response variant || cell ionizing radiation response variant |
| Cysteine-rich domain | 0.002706 | INHERITED FROM: thermotaxis variant || odorant positive chemotaxis variant || organism stress response variant || positive chemotaxis variant || acetylcholinesterase inhibitor response variant || bacterially unswollen || aldicarb response variant || odorant chemosensory response variant || pathogen induced gene expression variant || response to injury variant || thermosensory behavior variant || pathogen induced antimicrobial gene expression variant |
| F1F0 ATP synthase subunit C | 0.003479 | INHERITED FROM: organism stress response variant || avoids bacterial lawn |
| ARID-like | 0.003479 | INHERITED FROM: organism stress response variant || organism UV hypersensitive || organism UV response variant |
| FYVE/PHD zinc finger | 0.003525 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
| Periplasmic binding protein-like II | 0.003906 | INHERITED FROM: response to food variant || chemosensory response variant || thermotaxis variant || aqueous positive chemotaxis variant || chemotaxis variant || sodium chloride chemotaxis defective || sodium chloride chemotaxis variant || memory retention defective || organism starvation response variant || aqueous positive chemotaxis defective || positive chemotaxis defective || thermosensory behavior variant |
| SMAD/FHA domain | 0.004037 | INHERITED FROM: aldicarb response variant |
| Glutathione synthetase ATP-binding domain-like | 0.004037 | INHERITED FROM: negative chemotaxis variant || chemotaxis variant || osmotic avoidance variant |
| Zn-binding ribosomal proteins | 0.004991 | INHERITED FROM: response to bacteria variant || avoids bacterial lawn |
| Insulin-like | 0.00526 | INHERITED FROM: temperature induced dauer formation variant |
| Ligand-binding domain in the NO signalling and Golgi transport | 0.00608 | INHERITED FROM: carbon dioxide avoidance variant || carbon dioxide response variant || chemical response variant || anesthetic response variant || drug response variant |
| Thioredoxin-like | 0.00623 | INHERITED FROM: metal response variant || organism stress response variant || organism electrophilic stress hypersensitive || organism toxic chemical response variant || paraquat response variant || organism heat hypersensitive |
| Di-copper centre-containing domain | 0.008286 | INHERITED FROM: germ cell ionizing radiation response variant || cell ionizing radiation response variant || cell stress response variant || organism stress response variant || organism ionizing radiation response variant |
| Sm-like ribonucleoproteins | 0.008715 | INHERITED FROM: unfolded protein response variant || response to bacteria variant || avoids bacterial lawn || organism heat response variant |
| cAMP-binding domain-like | 0.009137 | INHERITED FROM: odorant negative chemotaxis defective || thermotaxis variant || carbon dioxide avoidance variant || chemotaxis variant || odorant positive chemotaxis variant || sodium chloride chemotaxis defective || organism temperature response variant || carbon dioxide response variant || positive chemotaxis variant || chemical response variant || anesthetic response variant || odorant positive chemotaxis defective || sodium chloride chemotaxis variant || benzaldehyde chemotaxis variant || odorant chemosensory response variant || butanone chemotaxis variant || positive chemotaxis defective || thermosensory behavior variant || benzaldehyde chemotaxis defective |
| DNA/RNA polymerases | 0.009386 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
| Aquaporin-like | 0.01274 | INHERITED FROM: organism stress response variant || organism osmotic stress response variant |
| PH domain-like | 0.01315 | INHERITED FROM: conflicting sensory integration variant || organism pathogen response variant || bacterially unswollen || aldicarb response variant || pathogen resistance increased || cellular osmotic stress response variant || response to injury variant |
| Troponin coil-coiled subunits | 0.01422 | INHERITED FROM: nicotine response variant || drug response variant |
| Class II aaRS ABD-related | 0.01422 | INHERITED FROM: hypoxia response variant || hypoxia resistant || organism stress response variant || response to bacteria variant || avoids bacterial lawn || oxygen response variant |
| "Winged helix" DNA-binding domain | 0.01675 | INHERITED FROM: anesthetic response variant |
| TPR-like | 0.01682 | INHERITED FROM: chemotaxis variant || ivermectin resistant || light body touch resistant || ivermectin response variant || positive chemotaxis defective || antihelmintic response variant |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.0186 | INHERITED FROM: stress induced lethality variant || organism hypertonic lethality increased || response to bacteria variant || stress induced lethality increased || avoids bacterial lawn || organism osmotic stress response variant |
| WW domain | 0.01937 | INHERITED FROM: acetylcholinesterase inhibitor resistant || aldicarb resistant |
| HSP20-like chaperones | 0.02061 | INHERITED FROM: cadmium hypersensitive || pathogen susceptibility increased || cadmium response variant |
| SH3-domain | 0.02381 | INHERITED FROM: aldicarb response variant |
| Spectrin repeat | 0.02539 | INHERITED FROM: aldicarb response variant || drug response variant |
| L30e-like | 0.03091 | INHERITED FROM: avoids bacterial lawn |
| NAD kinase/diacylglycerol kinase-like | 0.03158 | INHERITED FROM: thermotaxis variant || thermosensory behavior variant |
| HD-domain/PDEase-like | 0.03158 | INHERITED FROM: thermotaxis variant || organism temperature response variant || thermosensory behavior variant |
| Bromodomain | 0.03499 | INHERITED FROM: acute functional tolerance to alcohol defective || drug adaptation variant || anesthetic response variant || anesthetic resistant || organism UV hypersensitive || ethanol resistant || organism UV response variant |
| Ankyrin repeat | 0.03584 | INHERITED FROM: chemosensory response variant || odorant negative chemotaxis defective || chemotaxis variant || octanol chemotaxis defective || octanol chemotaxis variant || organism heat response variant |
| HAD-like | 0.03601 | INHERITED FROM: nicotine hypersensitive |
| WD40 repeat-like | 0.04424 | INHERITED FROM: osmotic avoidance variant || aldicarb response variant || pathogen induced antimicrobial gene expression variant |
| PLC-like phosphodiesterases | 0.07056 | INHERITED FROM: cell stress response variant || organism pathogen response variant || cellular osmotic stress response variant || response to injury variant || organism osmotic stress response variant |
| PYP-like sensor domain (PAS domain) | 0.0714 | INHERITED FROM: hypoxia response variant || carbon dioxide avoidance variant || carbon dioxide response variant || anesthetic response variant || oxygen response variant || hypoxia hypersensitive |
| Myosin rod fragments | 0.07477 | INHERITED FROM: drug resistant |
| HLH, helix-loop-helix DNA-binding domain | 0.08118 | INHERITED FROM: hypoxia response variant || fungal resistance increased || pathogen resistance increased || aqueous positive chemotaxis defective || lysine chemotaxis defective |
| Cation efflux protein cytoplasmic domain-like | 0.08964 | INHERITED FROM: metal response variant || cadmium hypersensitive || chemical hypersensitive || cadmium response variant |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.08964 | INHERITED FROM: pesticide response variant || organism oxidative stress response variant || organism toxic chemical response variant || paraquat response variant |
| Cation efflux protein transmembrane domain-like | 0.09094 | INHERITED FROM: metal response variant || cadmium hypersensitive || manganese toxicity resistant || manganese response variant |
| Saposin | 0.09906 | INHERITED FROM: germ cell ionizing radiation response variant || increased pathogen survival || germ cell resistant ionizing radiation || pathogen load variant || radiation induced germ cell apoptosis variant |
| PLP-dependent transferases | 0.1056 | INHERITED FROM: germ cell resistant ionizing radiation || radiation induced germ cell apoptosis variant |
| SNF-like | 0.1137 | INHERITED FROM: drug hypersensitive |
| Regulator of G-protein signaling, RGS | 0.1181 | INHERITED FROM: negative chemotaxis variant || mechanosensation variant || chemotaxis variant |
| t-snare proteins | 0.1183 | INHERITED FROM: drug hypersensitive |
| Arginase/deacetylase | 0.1183 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
| Voltage-gated potassium channels | 0.1244 | INHERITED FROM: phentolamine resistant || mechanosensation variant || serotonin response variant || imipramine resistant || serotonin resistant || adrenergic receptor antagonist response variant || positive chemotaxis defective |
| Multidrug efflux transporter AcrB transmembrane domain | 0.1529 | INHERITED FROM: chemotaxis variant || odorant positive chemotaxis defective || odorant chemosensory response variant || positive chemotaxis defective |
| ACP-like | 0.1545 | INHERITED FROM: organism starvation response variant |
| EF-hand | 0.1722 | INHERITED FROM: aldicarb response variant || cellular osmotic stress response variant |
| Heme-dependent peroxidases | 0.186 | INHERITED FROM: pathogen susceptibility increased |
| Immunoglobulin | 0.2033 | INHERITED FROM: aldicarb response variant |
| Homeodomain-like | 0.221 | INHERITED FROM: egg laying imipramine resistant || carbon dioxide avoidance variant || phentolamine resistant || carbon dioxide response variant || imipramine resistant || adrenergic receptor antagonist response variant |
| PRTase-like | 0.2306 | INHERITED FROM: drug resistant || Fluorouracil resistant |
| SAM/Pointed domain | 0.2354 | INHERITED FROM: aldicarb response variant |
| HMG-box | 0.2423 | INHERITED FROM: anesthetic response variant |
| Multidrug resistance efflux transporter EmrE | 0.2537 | INHERITED FROM: bacterially unswollen || response to bacteria variant || pathogen resistance increased |
| Lipocalins | 0.2821 | INHERITED FROM: paraquat hypersensitive |
| Quinoprotein alcohol dehydrogenase-like | 0.2982 | INHERITED FROM: hypoxia response variant || oxygen response variant |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.3142 | INHERITED FROM: response to bacteria variant || avoids bacterial lawn |
| Cytochrome P450 | 0.3801 | INHERITED FROM: metal response variant || cadmium hypersensitive || cadmium response variant |
| SNARE-like | 0.3838 | INHERITED FROM: acetylcholinesterase inhibitor resistant || aldicarb resistant |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0.3838 | INHERITED FROM: drug hypersensitive |
| RING/U-box | 0.3952 | INHERITED FROM: germ cell ionizing radiation response variant || cell ionizing radiation response variant || cell stress response variant || organism ionizing radiation response variant || germ cell hypersensitive ionizing radiation |
| Chromo domain-like | 0.4128 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
| ENTH/VHS domain | 0.4557 | INHERITED FROM: acetylcholinesterase inhibitor resistant || aldicarb resistant |
| FAD/NAD(P)-binding domain | 0.5306 | INHERITED FROM: pesticide response variant || organism oxidative stress response variant || organism toxic chemical response variant |
| Cystine-knot cytokines | 0.5886 | INHERITED FROM: levamisole response variant || nicotine response variant |
| EGF/Laminin | 0.6639 | INHERITED FROM: odorant negative chemotaxis defective || octanol chemotaxis defective || octanol chemotaxis variant |
| Metallo-dependent phosphatases | 0.6851 | INHERITED FROM: germ cell resistant ionizing radiation || radiation induced germ cell apoptosis variant |
| Nucleotide-diphospho-sugar transferases | 0.7204 | INHERITED FROM: lectin response variant || resistant to lectin |
| RNA-binding domain, RBD | 0.7422 | INHERITED FROM: innate immune response variant || starvation induced apoptosis variant || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant |
| Cysteine proteinases | 0.7506 | INHERITED FROM: paraquat hypersensitive |
| PDZ domain-like | 0.765 | INHERITED FROM: chemical resistant || acetylcholinesterase inhibitor response variant || drug resistant || aldicarb response variant |
| (Trans)glycosidases | 0.777 | INHERITED FROM: pathogen susceptibility increased |
| MFS general substrate transporter | 1 | INHERITED FROM: organism high sodium chloride hypersensitive |
| Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: SDS sensitive dauer |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: gamma ray induced apoptosis increased || organism gamma ray response variant || cell gamma ray response variant |
| Glucocorticoid receptor-like (DNA-binding domain) | 1 | INHERITED FROM: SDS sensitive dauer |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: serotonin induced pumping variant || serotonin induced fat reduction variant || male tail curling serotonin variant || locomotion rate serotonin variant |
| beta-beta-alpha zinc fingers | 1 | INHERITED FROM: egg laying imipramine resistant || inhibitor of serotonin uptake variant || imipramine resistant || egg laying serotonin resistant |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Epsilon subunit of mitochondrial F1F0-ATP synthase | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Heme-dependent catalase-like | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| LEM domain | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Cytochrome c | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| HRDC-like | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0.00000000000003503 | Direct |
| Transducin (alpha subunit), insertion domain | 0.000000000001442 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.00000000004387 | Direct |
| Histone-fold | 0.00000000005434 | Direct |
| Periplasmic binding protein-like I | 0.000000000608 | Direct |
| Nucleotide cyclase | 0.000000004435 | Direct |
| Nicotinic receptor ligand binding domain-like | 0.000000005752 | Direct |
| Skp1 dimerisation domain-like | 0.000001509 | Direct |
| GST C-terminal domain-like | 0.000003458 | Direct |
| Band 7/SPFH domain | 0.000005048 | Direct |
| DBL homology domain (DH-domain) | 0.00001083 | Direct |
| GroEL equatorial domain-like | 0.00002414 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00002414 | Direct |
| GroEL-intermediate domain like | 0.00002414 | Direct |
| Cullin repeat-like | 0.00002414 | Direct |
| Nucleotidylyl transferase | 0.00002695 | Direct |
| Class II aaRS and biotin synthetases | 0.00005151 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.00005362 | Direct |
| Tubulin C-terminal domain-like | 0.00009744 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.0001712 | Direct |
| GroEL apical domain-like | 0.0001712 | Direct |
| Tubulin nucleotide-binding domain-like | 0.0002638 | Direct |
| Cullin homology domain | 0.000295 | Direct |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.0005158 | Direct |
| DEATH domain | 0.0005382 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.0005382 | Direct |
| Calcium ATPase, transduction domain A | 0.0005796 | Direct |
| Protein kinase-like (PK-like) | 0.0005938 | Direct |
| Nucleic acid-binding proteins | 0.0006963 | Direct |
| Translation proteins SH3-like domain | 0.0007135 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0.00102 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.001198 | Inherited |
| ABC transporter transmembrane region | 0.001352 | Inherited |
| Actin-like ATPase domain | 0.001352 | Inherited |
| PIN domain-like | 0.001658 | Inherited |
| S15/NS1 RNA-binding domain | 0.001886 | Inherited |
| Leucine zipper domain | 0.002014 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.00228 | Inherited |
| Hect, E3 ligase catalytic domain | 0.002441 | Inherited |
| Cysteine-rich domain | 0.002706 | Inherited |
| F1F0 ATP synthase subunit C | 0.003479 | Inherited |
| ARID-like | 0.003479 | Inherited |
| FYVE/PHD zinc finger | 0.003525 | Inherited |
| Periplasmic binding protein-like II | 0.003906 | Inherited |
| SMAD/FHA domain | 0.004037 | Inherited |
| Glutathione synthetase ATP-binding domain-like | 0.004037 | Inherited |
| Zn-binding ribosomal proteins | 0.004991 | Inherited |
| Insulin-like | 0.00526 | Inherited |
| Ligand-binding domain in the NO signalling and Golgi transport | 0.00608 | Inherited |
| Thioredoxin-like | 0.00623 | Inherited |
| Di-copper centre-containing domain | 0.008286 | Inherited |
| Sm-like ribonucleoproteins | 0.008715 | Inherited |
| cAMP-binding domain-like | 0.009137 | Inherited |
| DNA/RNA polymerases | 0.009386 | Inherited |
| Aquaporin-like | 0.01274 | Inherited |
| PH domain-like | 0.01315 | Inherited |
| Troponin coil-coiled subunits | 0.01422 | Inherited |
| Class II aaRS ABD-related | 0.01422 | Inherited |
| "Winged helix" DNA-binding domain | 0.01675 | Inherited |
| TPR-like | 0.01682 | Inherited |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.0186 | Inherited |
| WW domain | 0.01937 | Inherited |
| HSP20-like chaperones | 0.02061 | Inherited |
| SH3-domain | 0.02381 | Inherited |
| Spectrin repeat | 0.02539 | Inherited |
| L30e-like | 0.03091 | Inherited |
| NAD kinase/diacylglycerol kinase-like | 0.03158 | Inherited |
| HD-domain/PDEase-like | 0.03158 | Inherited |
| Bromodomain | 0.03499 | Inherited |
| Ankyrin repeat | 0.03584 | Inherited |
| HAD-like | 0.03601 | Inherited |
| WD40 repeat-like | 0.04424 | Inherited |
| PLC-like phosphodiesterases | 0.07056 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.0714 | Inherited |
| Myosin rod fragments | 0.07477 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.08118 | Inherited |
| Cation efflux protein cytoplasmic domain-like | 0.08964 | Inherited |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.08964 | Inherited |
| Cation efflux protein transmembrane domain-like | 0.09094 | Inherited |
| Saposin | 0.09906 | Inherited |
| PLP-dependent transferases | 0.1056 | Inherited |
| SNF-like | 0.1137 | Inherited |
| Regulator of G-protein signaling, RGS | 0.1181 | Inherited |
| t-snare proteins | 0.1183 | Inherited |
| Arginase/deacetylase | 0.1183 | Inherited |
| Voltage-gated potassium channels | 0.1244 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.1529 | Inherited |
| ACP-like | 0.1545 | Inherited |
| EF-hand | 0.1722 | Inherited |
| Heme-dependent peroxidases | 0.186 | Inherited |
| Immunoglobulin | 0.2033 | Inherited |
| Homeodomain-like | 0.221 | Inherited |
| PRTase-like | 0.2306 | Inherited |
| SAM/Pointed domain | 0.2354 | Inherited |
| HMG-box | 0.2423 | Inherited |
| Multidrug resistance efflux transporter EmrE | 0.2537 | Inherited |
| Lipocalins | 0.2821 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.2982 | Inherited |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.3142 | Inherited |
| Cytochrome P450 | 0.3801 | Inherited |
| SNARE-like | 0.3838 | Inherited |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0.3838 | Inherited |
| RING/U-box | 0.3952 | Inherited |
| Chromo domain-like | 0.4128 | Inherited |
| ENTH/VHS domain | 0.4557 | Inherited |
| FAD/NAD(P)-binding domain | 0.5306 | Inherited |
| Cystine-knot cytokines | 0.5886 | Inherited |
| EGF/Laminin | 0.6639 | Inherited |
| Metallo-dependent phosphatases | 0.6851 | Inherited |
| Nucleotide-diphospho-sugar transferases | 0.7204 | Inherited |
| RNA-binding domain, RBD | 0.7422 | Inherited |
| Cysteine proteinases | 0.7506 | Inherited |
| PDZ domain-like | 0.765 | Inherited |
| (Trans)glycosidases | 0.777 | Inherited |
| MFS general substrate transporter | 1 | Inherited |
| Nuclear receptor ligand-binding domain | 1 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
| beta-beta-alpha zinc fingers | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | DIRECT |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0 | DIRECT |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | DIRECT |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | DIRECT |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | DIRECT |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
55729,55729
55729 - Acyl-CoA N-acyltransferases (Nat)
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | DIRECT |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | DIRECT |
48431,56968
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.000000000001442 | DIRECT |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.00000000004387 | DIRECT |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.00001228 | DIRECT |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0.0000125 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.00002414 | DIRECT |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.00002414 | DIRECT |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00002414 | DIRECT |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.00002541 | DIRECT |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.00005085 | DIRECT |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.00007726 | DIRECT |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.0002638 | DIRECT |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.0003799 | DIRECT |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.0005382 | DIRECT |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.00101 | INHERITED FROM: chemotaxis variant || ivermectin resistant || organism temperature response variant || aldicarb response variant || ivermectin response variant || aqueous chemosensory response variant || positive chemotaxis defective || antihelmintic response variant |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.001198 | INHERITED FROM: drug hypersensitive || nicotine hypersensitive |
56112,55073
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0.001198 | INHERITED FROM: chemosensory response variant || bromide chemotaxis variant || chemotaxis variant || anion positive chemotaxis defective || anion positive chemotaxis variant || positive chemotaxis variant || magnesium chemotaxis defective || chemical response variant || iodide chemotaxis variant || cation positive chemotaxis variant || AWC odorant chemotaxis variant || cation positive chemotaxis defective || benzaldehyde chemotaxis variant || AWC odorant chemotaxis defective || alkaline pH chemotaxis variant || lithium chemotaxis defective || aqueous chemosensory response variant || iodide chemotaxis defective || bromide chemotaxis defective |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.001352 | INHERITED FROM: metal response variant || cadmium hypersensitive || chemical response variant || chemical hypersensitive || colchicine hypersensitive || cadmium response variant |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.001886 | INHERITED FROM: organism stress response variant || organism UV hypersensitive || organism UV response variant |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.004991 | INHERITED FROM: drug response variant |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.004991 | INHERITED FROM: hypoxia response variant || hypoxia resistant || oxygen response variant |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.005315 | INHERITED FROM: thermotaxis variant || innate immune response variant || chemical resistant || organism temperature response variant || organism stress response variant || drug resistant || aldicarb response variant || pathogen induced gene expression variant || thermosensory behavior variant || pathogen induced antimicrobial gene expression variant || drug response variant |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0.01167 | INHERITED FROM: chemical response variant || drug response variant |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01167 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.02539 | INHERITED FROM: acetylcholinesterase inhibitor response variant || aldicarb response variant || drug response variant |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0.02645 | INHERITED FROM: response to bacteria variant || avoids bacterial lawn |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.03091 | INHERITED FROM: metal response variant || chemical response variant || cadmium response variant |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0.03675 | INHERITED FROM: drug response variant |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.08964 | INHERITED FROM: pesticide response variant || organism oxidative stress response variant || organism toxic chemical response variant || paraquat response variant |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0.08964 | INHERITED FROM: metal response variant || cadmium hypersensitive || chemical hypersensitive || cadmium response variant |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.1161 | INHERITED FROM: chemical resistant || drug resistant |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.1346 | INHERITED FROM: pesticide response variant || negative chemotaxis variant || mechanosensation variant || aqueous positive chemotaxis variant || chemotaxis variant || chemical resistant || osmotic avoidance variant || ivermectin resistant || positive chemotaxis variant || drug resistant || odorant chemosensory response variant || aqueous positive chemotaxis defective || ivermectin response variant || aqueous chemosensory response variant || positive chemotaxis defective |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0.1545 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
53300,56436
53300 - vWA-like
56436 - C-type lectin-like | 0.3379 | INHERITED FROM: pathogen induced death increased || pathogen susceptibility increased |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.3562 | INHERITED FROM: starvation induced apoptosis variant || organism starvation response variant |
56436,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.9805 | INHERITED FROM: cadmium hypersensitive || cadmium response variant |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 1 | INHERITED FROM: SDS sensitive dauer |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 1 | INHERITED FROM: cadmium hypersensitive || cadmium response variant |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | Direct |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | Direct |
81333,81333
81333 - F1F0 ATP synthase subunit C
81333 - F1F0 ATP synthase subunit C | 0 | Direct |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | Direct |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | Direct |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | Direct |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
55729,55729
55729 - Acyl-CoA N-acyltransferases (Nat)
55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | Direct |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | Direct |
48431,56968
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.000000000001442 | Direct |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.00000000004387 | Direct |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.00001228 | Direct |
54695,81382
54695 - POZ domain
81382 - Skp1 dimerisation domain-like | 0.0000125 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.00002414 | Direct |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.00002414 | Direct |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00002414 | Direct |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.00002541 | Direct |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.00005085 | Direct |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.00007726 | Direct |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.0002638 | Direct |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.0003799 | Direct |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.0005382 | Direct |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.00101 | Inherited |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.001198 | Inherited |
56112,55073
56112 - Protein kinase-like (PK-like)
55073 - Nucleotide cyclase | 0.001198 | Inherited |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.001352 | Inherited |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.001886 | Inherited |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.004991 | Inherited |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.004991 | Inherited |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.005315 | Inherited |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0.01167 | Inherited |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01167 | Inherited |
47473,47473
47473 - EF-hand
47473 - EF-hand | 0.02539 | Inherited |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0.02645 | Inherited |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.03091 | Inherited |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0.03675 | Inherited |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.08964 | Inherited |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0.08964 | Inherited |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.1161 | Inherited |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.1346 | Inherited |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0.1545 | Inherited |
53300,56436
53300 - vWA-like
56436 - C-type lectin-like | 0.3379 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.3562 | Inherited |
56436,49854
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.9805 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 1 | Inherited |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 1 | Inherited |
(show details)
Supra-domains annotated to this WP term (SPWP level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57362,57362,57362
57362 - BPTI-like
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
56968,48431,56968
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00002414 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.00002414 | DIRECT |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.0005382 | DIRECT |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.002765 | INHERITED FROM: drug hypersensitive || nicotine hypersensitive |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01167 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01167 | INHERITED FROM: chemical response variant |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01167 | INHERITED FROM: organism UV hypersensitive || organism UV response variant |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.01458 | INHERITED FROM: chemical resistant || drug resistant |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.03091 | INHERITED FROM: metal response variant || chemical response variant || cadmium response variant |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.03091 | INHERITED FROM: metal response variant || chemical response variant || cadmium response variant |
56436,56436,49854
56436 - C-type lectin-like
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.8076 | INHERITED FROM: cadmium hypersensitive || cadmium response variant |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57362,57362,57362
57362 - BPTI-like
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
56968,48431,56968
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00002414 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.00002414 | Direct |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.0005382 | Direct |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.002765 | Inherited |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01167 | Inherited |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01167 | Inherited |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01167 | Inherited |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.01458 | Inherited |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.03091 | Inherited |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.03091 | Inherited |
56436,56436,49854
56436 - C-type lectin-like
56436 - C-type lectin-like
49854 - Spermadhesin, CUB domain | 0.8076 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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