Worm Phenotype (WP): gametogenesis variant

(show info)

Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + + 4: Variant [WBPhenotype:0000886] <2>

+ + + 3: physiology variant [WBPhenotype:0000519] <14> (510|587) (510|248|68)

+ + 2: development variant [WBPhenotype:0000518] <6> (508|585) (508|248|68)

+ 1: cell development variant [WBPhenotype:0000529] <17> (119|124) (119|47|12)

0: gametogenesis variant [WBPhenotype:0000774] <2> (57|57) (58|22|4)

- 1: germ cell development variant [WBPhenotype:0000812] <7> (54|57) (55|22|4)

- 1: germ cell differentiation variant [WBPhenotype:0000894] <3> (38|40) (38|15|2)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)

SCOP term	FDR (all)	Annotation (direct or inherited)
Ribosomal protein L10-like	0	Direct
Helical domain of Sec23/24	0	Direct
Smc hinge domain	0	Direct
GroEL-intermediate domain like	0	Direct
GroEL equatorial domain-like	0	Direct
C-terminal, gelsolin-like domain of Sec23/24	0	Direct
LEM domain	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
14-3-3 protein	0	Direct
Zn-finger domain of Sec23/24	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
The spindle assembly checkpoint protein mad2	0	Direct
GroEL apical domain-like	0.0000000008706	Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase	0.000005598	Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.0000635	Direct
Histone-fold	0.0001234	Direct
ADC-like	0.0004136	Direct
RBP11-like subunits of RNA polymerase	0.0004136	Direct
Cdc48 domain 2-like	0.0004136	Direct
beta-sandwich domain of Sec23/24	0.0004136	Direct
Sm-like ribonucleoproteins	0.0004473	Direct
Nucleic acid-binding proteins	0.0006573	Direct
POZ domain	0.00167	Inherited
F1F0 ATP synthase subunit C	0.001748	Inherited
Ribosomal proteins S24e, L23 and L15e	0.001748	Inherited
S15/NS1 RNA-binding domain	0.001748	Inherited
P-loop containing nucleoside triphosphate hydrolases	0.003323	Inherited
Skp1 dimerisation domain-like	0.004221	Inherited
Translational machinery components	0.004491	Inherited
ACP-like	0.009057	Inherited
Translation proteins	0.01072	Inherited
PAZ domain	0.02276	Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.02481	Inherited
TPR-like	0.02643	Inherited
Ribosomal protein S5 domain 2-like	0.03321	Inherited
WD40 repeat-like	0.04654	Inherited
Class II aaRS ABD-related	0.06776	Inherited
L30e-like	0.06776	Inherited
"Winged helix" DNA-binding domain	0.06951	Inherited
Class II aaRS and biotin synthetases	0.07296	Inherited
Translation proteins SH3-like domain	0.07653	Inherited
ARM repeat	0.101	Inherited
HMG-box	0.1131	Inherited
Sec1/munc18-like (SM) proteins	0.123	Inherited
SET domain	0.1718	Inherited
Nucleotidylyl transferase	0.1748	Inherited
Activating enzymes of the ubiquitin-like proteins	0.2003	Inherited
SMAD MH1 domain	0.3112	Inherited
Cullin homology domain	0.3112	Inherited
CCCH zinc finger	0.327	Inherited
RNA-binding domain, RBD	0.3962	Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.402	Inherited
SNARE-like	0.402	Inherited
EGF/Laminin	0.5485	Inherited
Cysteine-rich domain	0.7771	Inherited
F-box domain	0.997	Inherited
Protein kinase-like (PK-like)	1	Inherited

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)

SCOP term	FDR (all)	Annotation (direct or inherited)
POU-specific domain	0	Direct
beta-sandwich domain of Sec23/24	0	Direct
Helical domain of Sec23/24	0	Direct
Smc hinge domain	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Zn-finger domain of Sec23/24	0	Direct
Group II chaperonin (CCT, TRIC), intermediate domain	0	Direct
RNA-polymerase beta	0	Direct
14-3-3 protein	0	Direct
Proteasome subunits	0	Direct
LEM domain	0	Direct
Trunk domain of Sec23/24	0	Direct
Group II chaperonin (CCT, TRIC), ATPase domain	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
C-terminal, gelsolin-like domain of Sec23/24	0	Direct
Group II chaperonin (CCT, TRIC), apical domain	0.00000001856	Direct
RecA protein-like (ATPase-domain)	0.000008982	Direct
Extended AAA-ATPase domain	0.00002935	Direct
Nucleosome core histones	0.0001419	Direct
Cdc48 domain 2-like	0.0005227	Direct
Anticodon-binding domain	0.0005227	Direct
Cdc48 N-terminal domain-like	0.0005227	Direct
BTB/POZ domain	0.0006853	Direct
Single strand DNA-binding domain, SSB	0.001047	Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP	0.002198	Inherited
F1F0 ATP synthase subunit C	0.002216	Inherited
Translational machinery components	0.002455	Inherited
Skp1 dimerisation domain-like	0.002954	Inherited
Pumilio repeat	0.008078	Inherited
Cyclin	0.008078	Inherited
WD40-repeat	0.0172	Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.03172	Inherited
Elongation factors	0.03192	Inherited
Cold shock DNA-binding domain-like	0.0365	Inherited
Ubiquitin-related	0.04573	Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain	0.05552	Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain	0.05893	Inherited
Retrovirus zinc finger-like domains	0.06237	Inherited
Actin/HSP70	0.08077	Inherited
RNA editing terminal uridyl transferase 2, RET2, domain 2	0.1039	Inherited
L30e/L7ae ribosomal proteins	0.1039	Inherited
Clathrin adaptor core protein	0.1039	Inherited
Anticodon-binding domain of Class II aaRS	0.1039	Inherited
SMAD domain	0.1729	Inherited
Motor proteins	0.225	Inherited
Canonical RBD	0.2275	Inherited
Nitrogenase iron protein-like	0.2776	Inherited
Cullin homology domain	0.2776	Inherited
SMAD MH1 domain	0.2776	Inherited
CCCH zinc finger	0.2888	Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	0.2888	Inherited
Tetratricopeptide repeat (TPR)	0.2888	Inherited
Histone lysine methyltransferases	0.3281	Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.4879	Inherited
G proteins	0.6486	Inherited
Protein serine/threonine phosphatase	0.8273	Inherited
Protein kinases, catalytic subunit	0.9931	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

Plot tree as:

Download Newick format tree:

(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Ribosomal protein L10-like	0	Direct
GroEL equatorial domain-like	0	Direct
C-terminal, gelsolin-like domain of Sec23/24	0	Direct
14-3-3 protein	0	Direct
LEM domain	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
GroEL-intermediate domain like	0	Direct
Helical domain of Sec23/24	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
The spindle assembly checkpoint protein mad2	0	Direct
Zn-finger domain of Sec23/24	0	Direct
Smc hinge domain	0	Direct
GroEL apical domain-like	0.0000000006911	Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase	0.000004552	Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.00005196	Direct
Histone-fold	0.0001012	Direct
Cdc48 domain 2-like	0.0003415	Direct
RBP11-like subunits of RNA polymerase	0.0003415	Direct
beta-sandwich domain of Sec23/24	0.0003415	Direct
ADC-like	0.0003415	Direct
Sm-like ribonucleoproteins	0.0003696	Direct
Nucleic acid-binding proteins	0.0005449	Direct
POZ domain	0.001397	Inherited
F1F0 ATP synthase subunit C	0.001463	Inherited
Ribosomal proteins S24e, L23 and L15e	0.001463	Inherited
S15/NS1 RNA-binding domain	0.001463	Inherited
P-loop containing nucleoside triphosphate hydrolases	0.002809	Inherited
Skp1 dimerisation domain-like	0.003578	Inherited
Translational machinery components	0.003811	Inherited
ACP-like	0.007774	Inherited
Translation proteins	0.009233	Inherited
PAZ domain	0.01985	Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.02169	Inherited
TPR-like	0.02314	Inherited
Ribosomal protein S5 domain 2-like	0.02922	Inherited
WD40 repeat-like	0.04116	Inherited
L30e-like	0.0605	Inherited
Class II aaRS ABD-related	0.0605	Inherited
"Winged helix" DNA-binding domain	0.06209	Inherited
Class II aaRS and biotin synthetases	0.06527	Inherited
Translation proteins SH3-like domain	0.06856	Inherited
Retrovirus zinc finger-like domains	0.06856	Inherited
ARM repeat	0.09123	Inherited
HMG-box	0.1024	Inherited
Sec1/munc18-like (SM) proteins	0.1117	Inherited
SET domain	0.1575	Inherited
Nucleotidylyl transferase	0.1605	Inherited
Activating enzymes of the ubiquitin-like proteins	0.1845	Inherited
Cullin homology domain	0.2918	Inherited
SMAD MH1 domain	0.2918	Inherited
CCCH zinc finger	0.3074	Inherited
RNA-binding domain, RBD	0.3757	Inherited
SNARE-like	0.3814	Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.3814	Inherited
EGF/Laminin	0.5266	Inherited
Cysteine-rich domain	0.758	Inherited
F-box domain	0.9867	Inherited
Protein kinase-like (PK-like)	1	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like	0	Direct
81811,82754 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24	0	Direct
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	Direct
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like	0	Direct
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like	0	Direct
81333,81333 81333 - F1F0 ATP synthase subunit C 81333 - F1F0 ATP synthase subunit C	0.0003415	Direct
52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain	0.0003415	Direct
49599,54695 49599 - TRAF domain-like 54695 - POZ domain	0.0007096	Direct
50249,55681 50249 - Nucleic acid-binding proteins 55681 - Class II aaRS and biotin synthetases	0.001463	Inherited
54695,81382 54695 - POZ domain 81382 - Skp1 dimerisation domain-like	0.005859	Inherited
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins	0.01403	Inherited
81301,81631 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain	0.01733	Inherited
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.02169	Inherited
52374,47323 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.0605	Inherited
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like	0.0605	Inherited
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	0.1122	Inherited
48371,48371 48371 - ARM repeat 48371 - ARM repeat	0.1137	Inherited
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.2506	Inherited
90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger	0.3447	Inherited
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.6592	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	Direct
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.02169	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

Plot tree as:

Download Newick format tree:

(show help)

SEARCH

BROWSE

TOOLS

ABOUT

HELP

Worm Phenotype (WP): gametogenesis variant

Superfamily

Family

Supra-domain (including individual superfamily)