Worm Phenotype (WP): pattern of transgene expression variant

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + + + + + 7: Variant [WBPhenotype:0000886] <2>

+ + + + + + 6: physiology variant [WBPhenotype:0000519] <14> (510|587) (510|248|68)

+ + + + + 5: organism physiology variant [WBPhenotype:0000576] <9> (369|431) (372|193|56)

+ + + + 4: organism homeostasis metabolism variant [WBPhenotype:0000577] <16> (361|421) (363|190|55)

+ + + 3: organism metabolism processing variant [WBPhenotype:0000027] <25> (178|190) (182|87|26)

+ + 2: gene expression variant [WBPhenotype:0000717] <11> (127|139) (131|64|20)

+ 1: transgene expression variant [WBPhenotype:0000306] <3> (82|99) (85|43|14)

0: pattern of transgene expression variant [WBPhenotype:0000961] <2> (49|61) (49|29|12)

- 1: ectopic expression transgene [WBPhenotype:0001276] (4|4) (4|1|0)

- 1: transgene subcellular localization variant [WBPhenotype:0000679] (30|44) (30|23|9)

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Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
F1F0 ATP synthase subunit C	0	Direct
FF domain	0	Direct
JAB1/MPN domain	0	Direct
Ribosomal protein L10-like	0	Direct
Helical domain of Sec23/24	0	Direct
Ribosomal proteins S24e, L23 and L15e	0	Direct
GroEL-intermediate domain like	0	Direct
GroEL equatorial domain-like	0	Direct
MIR domain	0	Direct
C-terminal, gelsolin-like domain of Sec23/24	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Class II aaRS ABD-related	0	Direct
14-3-3 protein	0	Direct
Cu,Zn superoxide dismutase-like	0	Direct
Zn-finger domain of Sec23/24	0	Direct
Subdomain of clathrin and coatomer appendage domain	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Clathrin adaptor appendage domain	0	Direct
HSP90 C-terminal domain	0	Direct
Chromo domain-like	0.00000000000003037	Direct
RING/U-box	0.00000000004926	Direct
SET domain	0.0000000001947	Direct
SNARE-like	0.00000002836	Direct
GroEL apical domain-like	0.0000003158	Direct
Cysteine proteinases	0.0000003667	Direct
Heat shock protein 70kD (HSP70), peptide-binding domain	0.000001558	Direct
Hect, E3 ligase catalytic domain	0.000001558	Direct
Cyclophilin-like	0.000002458	Direct
Sm-like ribonucleoproteins	0.000007067	Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0.0001798	Direct
FKBP-like	0.0002116	Direct
Activating enzymes of the ubiquitin-like proteins	0.0002316	Direct
P-loop containing nucleoside triphosphate hydrolases	0.0002483	Direct
Tudor/PWWP/MBT	0.0002961	Direct
UBC-like	0.0006718	Direct
L30e-like	0.0008126	Direct
Chaperone J-domain	0.0009128	Direct
HIT/MYND zinc finger-like	0.0009592	Direct
HSP20-like chaperones	0.005588	Inherited
Tubulin C-terminal domain-like	0.01015	Inherited
Acid proteases	0.01362	Inherited
Tubulin nucleotide-binding domain-like	0.01362	Inherited
B-box zinc-binding domain	0.03291	Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.07832	Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.182	Inherited
CCCH zinc finger	0.9262	Inherited
Homeodomain-like	1	Inherited
HLH, helix-loop-helix DNA-binding domain	1	Inherited
p53-like transcription factors	1	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
PDI-like	0	Direct
MIR domain	0	Direct
beta-sandwich domain of Sec23/24	0	Direct
Heat shock protein 90, HSP90, N-terminal domain	0	Direct
Brix domain	0	Direct
FF domain	0	Direct
Hsp90 middle domain	0	Direct
Cu,Zn superoxide dismutase-like	0	Direct
Quinoprotein alcohol dehydrogenase-like	0	Direct
Helical domain of Sec23/24	0	Direct
L30e/L7ae ribosomal proteins	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Zn-finger domain of Sec23/24	0	Direct
Group II chaperonin (CCT, TRIC), intermediate domain	0	Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	Direct
14-3-3 protein	0	Direct
Phoshoinositide 3-kinase (PI3K) helical domain	0	Direct
Clathrin coat assembly domain	0	Direct
Chromo domain	0	Direct
Trunk domain of Sec23/24	0	Direct
HSP90 C-terminal domain	0	Direct
Group II chaperonin (CCT, TRIC), ATPase domain	0	Direct
F1F0 ATP synthase subunit C	0	Direct
Integrin domains	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Anticodon-binding domain of Class II aaRS	0	Direct
C-terminal, gelsolin-like domain of Sec23/24	0	Direct
UBC-related	0.000000000001996	Direct
Forkhead DNA-binding domain	0.0000000001779	Direct
Pepsin-like	0.000000002337	Direct
Papain-like	0.000000007195	Direct
RING finger domain, C3HC4	0.00000001054	Direct
Ubiquitin carboxyl-terminal hydrolase, UCH	0.00000002626	Direct
Hect, E3 ligase catalytic domain	0.000004652	Direct
Group II chaperonin (CCT, TRIC), apical domain	0.000004652	Direct
Cyclophilin (peptidylprolyl isomerase)	0.00001176	Direct
Histone lysine methyltransferases	0.00001176	Direct
Translational machinery components	0.00001957	Direct
Heat shock protein 70kD (HSP70), peptide-binding domain	0.00001957	Direct
Clathrin adaptor core protein	0.00008195	Direct
Extended PAW domain	0.0001215	Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP	0.0001401	Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0.0003392	Direct
Armadillo repeat	0.0004525	Direct
FKBP immunophilin/proline isomerase	0.0005068	Direct
Chaperone J-domain	0.0005706	Direct
Nucleosome core histones	0.0009802	Direct
Ubiquitin activating enzymes (UBA)	0.00139	Inherited
Adenain-like	0.00139	Inherited
Tubulin, C-terminal domain	0.00712	Inherited
Tubulin, GTPase domain	0.009736	Inherited
B-box zinc-binding domain	0.02478	Inherited
PHD domain	0.03714	Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.06216	Inherited
HSP20	0.1137	Inherited
N-acetyl transferase, NAT	0.1188	Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.1534	Inherited
RecA protein-like (ATPase-domain)	0.2067	Inherited
CCCH zinc finger	0.8909	Inherited
Homeodomain	1	Inherited
HLH, helix-loop-helix DNA-binding domain	1	Inherited

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Ribosomal protein L10-like	0	Direct
F1F0 ATP synthase subunit C	0	Direct
GroEL equatorial domain-like	0	Direct
Clathrin adaptor appendage domain	0	Direct
C-terminal, gelsolin-like domain of Sec23/24	0	Direct
14-3-3 protein	0	Direct
Ribosomal proteins S24e, L23 and L15e	0	Direct
HSP90 C-terminal domain	0	Direct
JAB1/MPN domain	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Class II aaRS ABD-related	0	Direct
GroEL-intermediate domain like	0	Direct
Subdomain of clathrin and coatomer appendage domain	0	Direct
Helical domain of Sec23/24	0	Direct
FF domain	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
MIR domain	0	Direct
Zn-finger domain of Sec23/24	0	Direct
Cu,Zn superoxide dismutase-like	0	Direct
Chromo domain-like	0.00000000000002383	Direct
RING/U-box	0.00000000003894	Direct
SET domain	0.0000000001543	Direct
SNARE-like	0.00000002266	Direct
GroEL apical domain-like	0.000000254	Direct
Cysteine proteinases	0.0000002951	Direct
Hect, E3 ligase catalytic domain	0.000001261	Direct
Heat shock protein 70kD (HSP70), peptide-binding domain	0.000001261	Direct
Cyclophilin-like	0.000001993	Direct
Sm-like ribonucleoproteins	0.000005748	Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0.0001476	Direct
FKBP-like	0.0001739	Direct
Activating enzymes of the ubiquitin-like proteins	0.0001904	Direct
P-loop containing nucleoside triphosphate hydrolases	0.0002042	Direct
Tudor/PWWP/MBT	0.0002439	Direct
UBC-like	0.0005571	Direct
L30e-like	0.0006759	Direct
Chaperone J-domain	0.0007594	Direct
HIT/MYND zinc finger-like	0.000798	Direct
HSP20-like chaperones	0.004753	Inherited
Tubulin C-terminal domain-like	0.00873	Inherited
Tubulin nucleotide-binding domain-like	0.01178	Inherited
Acid proteases	0.01178	Inherited
B-box zinc-binding domain	0.02894	Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.07021	Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.1672	Inherited
CCCH zinc finger	0.9119	Inherited
Homeodomain-like	1	Inherited
p53-like transcription factors	1	Inherited
HLH, helix-loop-helix DNA-binding domain	1	Inherited

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like	0	Direct
81333,81333 81333 - F1F0 ATP synthase subunit C 81333 - F1F0 ATP synthase subunit C	0	Direct
54495,46934 54495 - UBC-like 46934 - UBA-like	0	Direct
81811,82754 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24	0	Direct
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	Direct
144232,82199 144232 - HIT/MYND zinc finger-like 82199 - SET domain	0	Direct
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	Direct
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat	0	Direct
54534,54534 54534 - FKBP-like 54534 - FKBP-like	0	Direct
55681,52954 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related	0	Direct
81698,81698 81698 - FF domain 81698 - FF domain	0	Direct
57903,51197 57903 - FYVE/PHD zinc finger 51197 - Clavaminate synthase-like	0	Direct
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
54160,54160 54160 - Chromo domain-like 54160 - Chromo domain-like	0	Direct
57903,82199 57903 - FYVE/PHD zinc finger 82199 - SET domain	0	Direct
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like	0	Direct
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like	0	Direct
64356,49447 64356 - SNARE-like 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	Direct
54160,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
49348,55711 49348 - Clathrin adaptor appendage domain 55711 - Subdomain of clathrin and coatomer appendage domain	0	Direct
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.000001261	Direct
48452,48452 48452 - TPR-like 48452 - TPR-like	0.00004559	Direct
52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like	0.0003569	Direct
57850,57850 57850 - RING/U-box 57850 - RING/U-box	0.002505	Inherited
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like	0.01178	Inherited
57850,57845 57850 - RING/U-box 57845 - B-box zinc-binding domain	0.09388	Inherited
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.1672	Inherited
90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger	0.5789	Inherited

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
54160,54160,52540 54160 - Chromo domain-like 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
48452,48452,48452 48452 - TPR-like 48452 - TPR-like 48452 - TPR-like	0	Direct
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0	Direct
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	Direct
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	Direct
54160,52540,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.000001261	Direct
52833,52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like 52833 - Thioredoxin-like	0.0005054	Direct
57850,57850,57850 57850 - RING/U-box 57850 - RING/U-box 57850 - RING/U-box	0.0006759	Direct
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.1672	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Worm Phenotype (WP): pattern of transgene expression variant

Superfamily

Family

Supra-domain (including individual superfamily)