Worm Phenotype (WP): protein interaction variant

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + + + 5: Variant [WBPhenotype:0000886] <2>

+ + + + 4: physiology variant [WBPhenotype:0000519] <14> (510|587) (510|248|68)

+ + + 3: organism physiology variant [WBPhenotype:0000576] <9> (369|431) (372|193|56)

+ + 2: organism homeostasis metabolism variant [WBPhenotype:0000577] <16> (361|421) (363|190|55)

+ 1: organism metabolism processing variant [WBPhenotype:0000027] <25> (178|190) (182|87|26)

0: protein interaction variant [WBPhenotype:0001369] <4> (47|49) (48|21|9)

- 1: protein RNA interaction variant [WBPhenotype:0001371] <2> (0|0) (0|0|0)

- 1: protein protein interaction variant [WBPhenotype:0001370] <2> (44|49) (45|19|8)

- 1: microtubule polymerization variant [WBPhenotype:0001591] (0|0) (0|0|0)

- 1: protein DNA interaction variant [WBPhenotype:0001372] (0|0) (0|0|0)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
JAB1/MPN domain	0	Direct
RING/U-box	0	Direct
GroEL-intermediate domain like	0	Direct
GroEL equatorial domain-like	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
14-3-3 protein	0	Direct
Cu,Zn superoxide dismutase-like	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Cysteine proteinases	0.00000000000001252	Direct
UBC-like	0.00000000002483	Direct
Chaperone J-domain	0.0000000002735	Direct
Acid proteases	0.00000000259	Direct
Heat shock protein 70kD (HSP70), peptide-binding domain	0.000000002811	Direct
Hect, E3 ligase catalytic domain	0.000000002811	Direct
B-box zinc-binding domain	0.0000001309	Direct
Cyclophilin-like	0.0000004794	Direct
FKBP-like	0.000001019	Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.000006361	Direct
GroEL apical domain-like	0.000006361	Direct
HSP20-like chaperones	0.00001098	Direct
Tubulin nucleotide-binding domain-like	0.00002785	Direct
Ubiquitin-like	0.00004565	Direct
EF-hand	0.00007281	Direct
Tubulin C-terminal domain-like	0.00008619	Direct
Actin-like ATPase domain	0.000131	Direct
Galactose-binding domain-like	0.0001797	Direct
ADC-like	0.0002656	Direct
WWE domain	0.0002656	Direct
Cdc48 domain 2-like	0.0002656	Direct
MIT domain	0.0002656	Direct
Activating enzymes of the ubiquitin-like proteins	0.0002952	Direct
HSP40/DnaJ peptide-binding domain	0.001143	Inherited
Seven-hairpin glycosidases	0.003596	Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.005051	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.005704	Inherited
UBA-like	0.008736	Inherited
Sec1/munc18-like (SM) proteins	0.01487	Inherited
Skp1 dimerisation domain-like	0.02721	Inherited
Cullin homology domain	0.03711	Inherited
PYP-like sensor domain (PAS domain)	0.03711	Inherited
WD40 repeat-like	0.04494	Inherited
Translation proteins	0.05996	Inherited
Cullin repeat-like	0.07167	Inherited
"Winged helix" DNA-binding domain	0.2505	Inherited
RNI-like	0.6893	Inherited
POZ domain	0.9991	Inherited
F-box domain	1	Inherited

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
PDI-like	0	Direct
Cu,Zn superoxide dismutase-like	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Group II chaperonin (CCT, TRIC), intermediate domain	0	Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	Direct
14-3-3 protein	0	Direct
RING finger domain, C3HC4	0	Direct
Group II chaperonin (CCT, TRIC), ATPase domain	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Pepsin-like	0.00000000000003804	Direct
UBC-related	0.0000000000002294	Direct
Papain-like	0.0000000001793	Direct
Chaperone J-domain	0.000000000239	Direct
Ubiquitin carboxyl-terminal hydrolase, UCH	0.0000000077	Direct
Hect, E3 ligase catalytic domain	0.000000009229	Direct
Heat shock protein 70kD (HSP70), peptide-binding domain	0.00000007924	Direct
Extended PAW domain	0.0000001043	Direct
B-box zinc-binding domain	0.0000001062	Direct
Cyclophilin (peptidylprolyl isomerase)	0.0000003885	Direct
Ubiquitin-related	0.000001013	Direct
FKBP immunophilin/proline isomerase	0.000002746	Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.000005117	Direct
Group II chaperonin (CCT, TRIC), apical domain	0.00001847	Direct
Calmodulin-like	0.00002233	Direct
Tubulin, GTPase domain	0.000023	Direct
Actin/HSP70	0.00002474	Direct
Ubiquitin activating enzymes (UBA)	0.00004728	Direct
HSP20	0.00006646	Direct
Tubulin, C-terminal domain	0.00007139	Direct
Cdc48 domain 2-like	0.0003864	Direct
WWE domain	0.0003864	Direct
MIT domain	0.0003864	Direct
Cdc48 N-terminal domain-like	0.0003864	Direct
Class I alpha-1;2-mannosidase, catalytic domain	0.002938	Inherited
Elongation factors	0.004128	Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.004192	Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP	0.004411	Inherited
Proteasome subunits	0.007447	Inherited
Cullin repeat	0.0126	Inherited
Sec1/munc18-like (SM) proteins	0.0126	Inherited
SCF ubiquitin ligase complex WHB domain	0.0126	Inherited
RecA protein-like (ATPase-domain)	0.0126	Inherited
Clathrin adaptor core protein	0.03227	Inherited
Cullin homology domain	0.03227	Inherited
Skp1 dimerisation domain-like	0.03741	Inherited
Thioltransferase	0.1083	Inherited
BTB/POZ domain	0.2958	Inherited
WD40-repeat	0.331	Inherited
F-box domain	0.6421	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
GroEL equatorial domain-like	0	Direct
RING/U-box	0	Direct
14-3-3 protein	0	Direct
JAB1/MPN domain	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
GroEL-intermediate domain like	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Cu,Zn superoxide dismutase-like	0	Direct
Cysteine proteinases	0.000000000000009822	Direct
UBC-like	0.00000000001961	Direct
Chaperone J-domain	0.0000000002168	Direct
Acid proteases	0.00000000206	Direct
Hect, E3 ligase catalytic domain	0.000000002237	Direct
Heat shock protein 70kD (HSP70), peptide-binding domain	0.000000002237	Direct
B-box zinc-binding domain	0.0000001049	Direct
Cyclophilin-like	0.0000003862	Direct
FKBP-like	0.0000008231	Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.000005171	Direct
GroEL apical domain-like	0.000005171	Direct
HSP20-like chaperones	0.000008931	Direct
Tubulin nucleotide-binding domain-like	0.00002273	Direct
Ubiquitin-like	0.00003732	Direct
EF-hand	0.00005956	Direct
Tubulin C-terminal domain-like	0.00007059	Direct
Actin-like ATPase domain	0.0001074	Direct
Galactose-binding domain-like	0.0001475	Direct
Cdc48 domain 2-like	0.0002186	Direct
MIT domain	0.0002186	Direct
WWE domain	0.0002186	Direct
ADC-like	0.0002186	Direct
Activating enzymes of the ubiquitin-like proteins	0.0002432	Direct
HSP40/DnaJ peptide-binding domain	0.0009522	Direct
Seven-hairpin glycosidases	0.003044	Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.004292	Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.004854	Inherited
UBA-like	0.007493	Inherited
Sec1/munc18-like (SM) proteins	0.01288	Inherited
Skp1 dimerisation domain-like	0.02384	Inherited
Cullin homology domain	0.03269	Inherited
PYP-like sensor domain (PAS domain)	0.03269	Inherited
WD40 repeat-like	0.03972	Inherited
Translation proteins SH3-like domain	0.04969	Inherited
Translation proteins	0.05338	Inherited
Cullin repeat-like	0.06409	Inherited
"Winged helix" DNA-binding domain	0.2327	Inherited
RNI-like	0.6684	Inherited
POZ domain	0.9889	Inherited
F-box domain	0.9917	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like	0	Direct
54495,46934 54495 - UBC-like 46934 - UBA-like	0	Direct
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	Direct
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	Direct
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
54534,54534 54534 - FKBP-like 54534 - FKBP-like	0	Direct
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like	0	Direct
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.000000002237	Direct
52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like	0.00000004602	Direct
57850,57850 57850 - RING/U-box 57850 - RING/U-box	0.00001694	Direct
57850,57845 57850 - RING/U-box 57845 - B-box zinc-binding domain	0.00001879	Direct
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like	0.00002273	Direct
49785,49785 49785 - Galactose-binding domain-like 49785 - Galactose-binding domain-like	0.0001034	Direct
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	0.0001074	Direct
49493,49493 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain	0.0009522	Direct
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins	0.004176	Inherited
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.004292	Inherited
74788,75632 74788 - Cullin repeat-like 75632 - Cullin homology domain	0.01288	Inherited
75632,46785 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain	0.01288	Inherited
54695,81382 54695 - POZ domain 81382 - Skp1 dimerisation domain-like	0.0146	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	Direct
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	Direct
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.000000002237	Direct
52833,52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like 52833 - Thioredoxin-like	0.0000000998	Direct
57850,57850,57850 57850 - RING/U-box 57850 - RING/U-box 57850 - RING/U-box	0.000006577	Direct
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.004292	Inherited
74788,75632,46785 74788 - Cullin repeat-like 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain	0.01288	Inherited

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Worm Phenotype (WP): protein interaction variant

Superfamily

Family

Supra-domain (including individual superfamily)