Worm Phenotype (WP): protein aggregation variant

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + + + + + 7: Variant [WBPhenotype:0000886] <2>

+ + + + + + 6: physiology variant [WBPhenotype:0000519] <14> (510|587) (510|248|68)

+ + + + + 5: organism physiology variant [WBPhenotype:0000576] <9> (369|431) (372|193|56)

+ + + + 4: organism homeostasis metabolism variant [WBPhenotype:0000577] <16> (361|421) (363|190|55)

+ + + 3: organism metabolism processing variant [WBPhenotype:0000027] <25> (178|190) (182|87|26)

+ + 2: protein interaction variant [WBPhenotype:0001369] <4> (47|49) (48|21|9)

+ 1: protein protein interaction variant [WBPhenotype:0001370] <2> (44|49) (45|19|8)

0: protein aggregation variant [WBPhenotype:0001405] <1> (43|48) (44|19|8)

- 1: protein aggregation induced behavior variant [WBPhenotype:0002425] <3> (9|10) (9|3|1)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
JAB1/MPN domain	0	Direct
UBC-like	0	Direct
RING/U-box	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Chaperone J-domain	0	Direct
Cysteine proteinases	0	Direct
Cu,Zn superoxide dismutase-like	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Acid proteases	0.0000000000004116	Direct
HSP20-like chaperones	0.00000000001564	Direct
Tubulin nucleotide-binding domain-like	0.00000000006412	Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.0000000001861	Direct
Tubulin C-terminal domain-like	0.000000000247	Direct
B-box zinc-binding domain	0.000000000808	Direct
Heat shock protein 70kD (HSP70), peptide-binding domain	0.000000001976	Direct
Hect, E3 ligase catalytic domain	0.000000001976	Direct
Cyclophilin-like	0.000000006209	Direct
Actin-like ATPase domain	0.00000002733	Direct
Ubiquitin-like	0.0000001265	Direct
FKBP-like	0.0000007525	Direct
Galactose-binding domain-like	0.000001488	Direct
Activating enzymes of the ubiquitin-like proteins	0.00000155	Direct
WD40 repeat-like	0.00001974	Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.00006807	Direct
"Winged helix" DNA-binding domain	0.00008342	Direct
EF-hand	0.0001161	Direct
Sec1/munc18-like (SM) proteins	0.0001205	Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.000132	Direct
ADC-like	0.0002287	Direct
WWE domain	0.0002287	Direct
Cdc48 domain 2-like	0.0002287	Direct
MIT domain	0.0002287	Direct
Cullin homology domain	0.0003718	Direct
Seven-hairpin glycosidases	0.0003718	Direct
UBA-like	0.0005398	Direct
Translation proteins	0.000762	Direct
PYP-like sensor domain (PAS domain)	0.0008764	Direct
HSP40/DnaJ peptide-binding domain	0.0009864	Direct
Cullin repeat-like	0.001748	Inherited
Skp1 dimerisation domain-like	0.02297	Inherited
RNI-like	0.6523	Inherited
F-box domain	0.9854	Inherited
POZ domain	1	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
PDI-like	0	Direct
UBC-related	0	Direct
Cu,Zn superoxide dismutase-like	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Group II chaperonin (CCT, TRIC), intermediate domain	0	Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	Direct
RING finger domain, C3HC4	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Chaperone J-domain	0.000000000000008126	Direct
Pepsin-like	0.0000000000000206	Direct
Papain-like	0.0000000000007302	Direct
Ubiquitin carboxyl-terminal hydrolase, UCH	0.00000000002346	Direct
Tubulin, GTPase domain	0.0000000003968	Direct
Actin/HSP70	0.0000000004025	Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.0000000007286	Direct
Tubulin, C-terminal domain	0.000000001504	Direct
Ubiquitin-related	0.000000004117	Direct
B-box zinc-binding domain	0.000000004831	Direct
Hect, E3 ligase catalytic domain	0.000000006528	Direct
Cyclophilin (peptidylprolyl isomerase)	0.00000003134	Direct
HSP20	0.00000005822	Direct
Group II chaperonin (CCT, TRIC), ATPase domain	0.00000005822	Direct
Heat shock protein 70kD (HSP70), peptide-binding domain	0.00000005822	Direct
Extended PAW domain	0.00000006954	Direct
Group II chaperonin (CCT, TRIC), apical domain	0.0000004627	Direct
FKBP immunophilin/proline isomerase	0.000002041	Direct
Proteasome subunits	0.000007141	Direct
Calmodulin-like	0.00001336	Direct
Ubiquitin activating enzymes (UBA)	0.00003916	Direct
Cullin repeat	0.0002035	Direct
Sec1/munc18-like (SM) proteins	0.0002035	Direct
SCF ubiquitin ligase complex WHB domain	0.0002035	Direct
RecA protein-like (ATPase-domain)	0.0002035	Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.0002551	Direct
Cdc48 domain 2-like	0.0003326	Direct
WWE domain	0.0003326	Direct
MIT domain	0.0003326	Direct
Cdc48 N-terminal domain-like	0.0003326	Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP	0.0004142	Direct
Clathrin adaptor core protein	0.0006209	Direct
Class I alpha-1;2-mannosidase, catalytic domain	0.0006209	Direct
Cullin homology domain	0.0006209	Direct
Elongation factors	0.0007495	Direct
WD40-repeat	0.02552	Inherited
Skp1 dimerisation domain-like	0.03175	Inherited
Thioltransferase	0.09703	Inherited
BTB/POZ domain	0.3919	Inherited
F-box domain	0.6006	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
RING/U-box	0	Direct
Cysteine proteinases	0	Direct
Chaperone J-domain	0	Direct
JAB1/MPN domain	0	Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
UBC-like	0	Direct
Cu,Zn superoxide dismutase-like	0	Direct
Acid proteases	0.0000000000003238	Direct
HSP20-like chaperones	0.00000000001235	Direct
Tubulin nucleotide-binding domain-like	0.0000000000507	Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.0000000001474	Direct
Tubulin C-terminal domain-like	0.0000000001957	Direct
B-box zinc-binding domain	0.0000000006414	Direct
Hect, E3 ligase catalytic domain	0.000000001571	Direct
Heat shock protein 70kD (HSP70), peptide-binding domain	0.000000001571	Direct
Cyclophilin-like	0.000000004947	Direct
Actin-like ATPase domain	0.00000002183	Direct
Ubiquitin-like	0.0000001014	Direct
FKBP-like	0.0000006073	Direct
Galactose-binding domain-like	0.000001205	Direct
Activating enzymes of the ubiquitin-like proteins	0.000001255	Direct
WD40 repeat-like	0.0000161	Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.00005568	Direct
"Winged helix" DNA-binding domain	0.0000683	Direct
EF-hand	0.00009519	Direct
Sec1/munc18-like (SM) proteins	0.00009882	Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.0001082	Direct
Cdc48 domain 2-like	0.000188	Direct
MIT domain	0.000188	Direct
WWE domain	0.000188	Direct
ADC-like	0.000188	Direct
Cullin homology domain	0.0003066	Direct
Seven-hairpin glycosidases	0.0003066	Direct
UBA-like	0.000447	Direct
Translation proteins	0.0006331	Direct
PYP-like sensor domain (PAS domain)	0.0007292	Direct
HSP40/DnaJ peptide-binding domain	0.0008209	Direct
Translation proteins SH3-like domain	0.0008598	Direct
Cullin repeat-like	0.001463	Inherited
Skp1 dimerisation domain-like	0.02005	Inherited
RNI-like	0.6308	Inherited
F-box domain	0.9744	Inherited
POZ domain	1	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
54495,46934 54495 - UBC-like 46934 - UBA-like	0	Direct
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	Direct
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
54534,54534 54534 - FKBP-like 54534 - FKBP-like	0	Direct
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like	0	Direct
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like	0.0000000000507	Direct
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	0.000000001247	Direct
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.000000001571	Direct
52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like	0.00000003143	Direct
57850,57845 57850 - RING/U-box 57845 - B-box zinc-binding domain	0.000001895	Direct
57850,57850 57850 - RING/U-box 57850 - RING/U-box	0.00001266	Direct
49785,49785 49785 - Galactose-binding domain-like 49785 - Galactose-binding domain-like	0.00008054	Direct
74788,75632 74788 - Cullin repeat-like 75632 - Cullin homology domain	0.00009882	Direct
75632,46785 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain	0.00009882	Direct
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.0001082	Direct
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins	0.0001583	Direct
49493,49493 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain	0.0008209	Direct
54695,81382 54695 - POZ domain 81382 - Skp1 dimerisation domain-like	0.01222	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	Direct
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.000000001571	Direct
52833,52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like 52833 - Thioredoxin-like	0.00000007071	Direct
57850,57850,57850 57850 - RING/U-box 57850 - RING/U-box 57850 - RING/U-box	0.000005051	Direct
74788,75632,46785 74788 - Cullin repeat-like 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain	0.00009882	Direct
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.0001082	Direct

Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term

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Worm Phenotype (WP): protein aggregation variant

Superfamily

Family

Supra-domain (including individual superfamily)