Worm Phenotype (WP): locomotor coordination variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children)	WP term [WP ID] <#Children>	(#SF|#FA)	#Supra-domain (Single|Duplex|Triple)
+ + + + + + 6:	Variant [WBPhenotype:0000886] <2>
+ + + + + 5:	physiology variant [WBPhenotype:0000519] <14>	(510|587)	(510|248|68)
+ + + + 4:	behavior variant [WBPhenotype:0000517] <2>	(119|121)	(119|54|20)
+ + + 3:	organism behavior variant [WBPhenotype:0000525] <20>	(119|121)	(119|54|20)
+ + 2:	movement variant [WBPhenotype:0001206] <4>	(48|56)	(48|25|14)
+ 1:	locomotion variant [WBPhenotype:0000643] <4>	(46|52)	(46|23|12)
0:	locomotor coordination variant [WBPhenotype:0004017] <7>	(18|21)	(18|7|1)
- 1:	spastic locomotion [WBPhenotype:0001701] <6>	(0|0)	(0|0|0)
- 1:	kinker [WBPhenotype:0000002] <3>	(0|0)	(0|0|0)
- 1:	coiler [WBPhenotype:0000565] <2>	(0|0)	(0|0|0)
- 1:	directionality variant [WBPhenotype:0001702] <2>	(15|16)	(15|6|1)
- 1:	path curvature variant [WBPhenotype:0002335] <2>	(6|6)	(6|3|0)
- 1:	roller [WBPhenotype:0000645] <2>	(2|3)	(2|0|0)
- 1:	sinusoidal movement variant [WBPhenotype:0004018] <2>	(10|14)	(10|5|1)

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Superfamily

Superfamily domains annotated to this WP term (Not in SDWP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
SNF-like	0.00000000000009268	DIRECT
Transducin (alpha subunit), insertion domain	0.00000000000105	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0.00000000007238	DIRECT
Nicotinic receptor ligand binding domain-like	0.0000000002177	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0.000008343	DIRECT
E2F-DP heterodimerization region	0.000008343	DIRECT
Voltage-gated potassium channels	0.00003677	DIRECT
C2 domain (Calcium/lipid-binding domain, CaLB)	0.0001342	DIRECT
Ankyrin repeat	0.001347	INHERITED FROM: sinusoidal movement variant || turning variant || backward locomotion variant || reversal variant || body bend variant || turning frequency variant
Fibronectin type III	0.002293	INHERITED FROM: path curvature increased || reversal variant
Insulin-like	0.003505	INHERITED FROM: sinusoidal movement variant || turning variant || turning frequency reduced || backward locomotion variant || reversal variant || body bend variant || amplitude of sinusoidal movement variant || turning frequency variant
PH domain-like	0.004514	INHERITED FROM: body bend variant
SMAD MH1 domain	0.009787	INHERITED FROM: sinusoidal movement variant || turning variant || backward locomotion variant || reversal variant || body bend variant || directionality variant || amplitude of sinusoidal movement variant || frequency of body bend variant || turning frequency variant
P-loop containing nucleoside triphosphate hydrolases	0.03444	INHERITED FROM: backward locomotion variant || turning frequency variant
SMAD/FHA domain	0.05737	INHERITED FROM: sinusoidal movement variant || path curvature increased || turning variant || backward locomotion variant || reversal variant || body bend variant || directionality variant || amplitude of sinusoidal movement variant || frequency of body bend variant || turning frequency variant
Homeodomain-like	0.07315	INHERITED FROM: backward locomotion variant
cAMP-binding domain-like	0.07604	INHERITED FROM: roller || turning variant || path curvature variant || body bend variant || directionality variant || amplitude of sinusoidal movement variant || frequency of body bend variant || turning frequency variant
PLP-dependent transferases	0.09601	INHERITED FROM: path curvature decreased

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Family

Family domains annotated to this WP term (SDWP level: Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
SNF-like	0.0000000000003025	DIRECT
Transducin (alpha subunit), insertion domain	0.000000000001882	DIRECT
Nicotinic receptor ligand binding domain-like	0.0000000001705	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0.0000000001705	DIRECT
G proteins	0.0000005971	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0.00001589	DIRECT
Cell cycle transcription factor e2f-dp	0.00001589	DIRECT
Pyridoxal-dependent decarboxylase	0.00008192	DIRECT
Voltage-gated potassium channels	0.00012	DIRECT
Pleckstrin-homology domain (PH domain)	0.0001435	DIRECT
Rhodopsin-like	0.000168	DIRECT
PLC-like (P variant)	0.0002657	DIRECT
Fibronectin type III	0.002557	INHERITED FROM: path curvature increased
I set domains	0.003803	INHERITED FROM: path curvature increased
Insulin-like	0.00399	INHERITED FROM: sinusoidal movement variant || turning variant || turning frequency reduced || backward locomotion variant || reversal variant || body bend variant || amplitude of sinusoidal movement variant || turning frequency variant
Ankyrin repeat	0.006006	INHERITED FROM: sinusoidal movement variant || turning variant || backward locomotion variant || reversal variant || body bend variant || turning frequency variant
SMAD domain	0.009278	INHERITED FROM: sinusoidal movement variant || turning variant || backward locomotion variant || reversal variant || body bend variant || directionality variant || amplitude of sinusoidal movement variant || frequency of body bend variant || turning frequency variant
SMAD MH1 domain	0.009278	INHERITED FROM: sinusoidal movement variant || turning variant || backward locomotion variant || reversal variant || body bend variant || directionality variant || amplitude of sinusoidal movement variant || frequency of body bend variant || turning frequency variant
Synaptotagmin-like (S variant)	0.03371	INHERITED FROM: roller
Homeodomain	0.05561	INHERITED FROM: backward locomotion variant
cAMP-binding domain	0.07499	INHERITED FROM: roller || turning variant || path curvature variant || directionality variant || amplitude of sinusoidal movement variant || frequency of body bend variant || turning frequency variant

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Supra-domain (including individual superfamily)

Supra-domains annotated to this WP term (SPWP level: Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
SNF-like	0.00000000000007278	DIRECT
Transducin (alpha subunit), insertion domain	0.0000000000008267	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0.00000000005725	DIRECT
Nicotinic receptor ligand binding domain-like	0.0000000001725	DIRECT
E2F-DP heterodimerization region	0.000006783	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0.000006783	DIRECT
Voltage-gated potassium channels	0.00003003	DIRECT
C2 domain (Calcium/lipid-binding domain, CaLB)	0.00011	DIRECT
Ankyrin repeat	0.001124	INHERITED FROM: turning variant || body bend variant || reversal variant || sinusoidal movement variant || turning frequency variant || backward locomotion variant
Fibronectin type III	0.001928	INHERITED FROM: reversal variant || path curvature increased
Insulin-like	0.002966	INHERITED FROM: amplitude of sinusoidal movement variant || turning variant || body bend variant || reversal variant || turning frequency reduced || sinusoidal movement variant || turning frequency variant || backward locomotion variant
PH domain-like	0.003831	INHERITED FROM: body bend variant
SMAD MH1 domain	0.008413	INHERITED FROM: amplitude of sinusoidal movement variant || turning variant || body bend variant || directionality variant || reversal variant || sinusoidal movement variant || turning frequency variant || backward locomotion variant || frequency of body bend variant
P-loop containing nucleoside triphosphate hydrolases	0.03031	INHERITED FROM: turning frequency variant || backward locomotion variant
SMAD/FHA domain	0.05102	INHERITED FROM: amplitude of sinusoidal movement variant || turning variant || body bend variant || directionality variant || reversal variant || sinusoidal movement variant || path curvature increased || turning frequency variant || backward locomotion variant || frequency of body bend variant
Homeodomain-like	0.06545	INHERITED FROM: backward locomotion variant
cAMP-binding domain-like	0.06811	INHERITED FROM: amplitude of sinusoidal movement variant || turning variant || body bend variant || directionality variant || sinusoidal movement variant || path curvature variant || turning frequency variant || frequency of body bend variant || roller
PLP-dependent transferases	0.08658	INHERITED FROM: path curvature decreased

Supra-domains annotated to this WP term (SPWP level: Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region	0	DIRECT
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0.0000000000008267	DIRECT
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore	0.00000000005725	DIRECT
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III	0.0009476	DIRECT
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.0009811	DIRECT
48403,48403 48403 - Ankyrin repeat 48403 - Ankyrin repeat	0.008413	INHERITED FROM: amplitude of sinusoidal movement variant || turning variant || body bend variant || backing decreased || directionality variant || reversal variant || sinusoidal movement variant || path curvature variant || turning frequency variant || backward locomotion variant || frequency of body bend variant
47473,47473 47473 - EF-hand 47473 - EF-hand	0.03047	INHERITED FROM: body bend variant || sinusoidal movement variant

Supra-domains annotated to this WP term (SPWP level: Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin	0.001034	INHERITED FROM: amplitude of sinusoidal movement variant || turning variant || body bend variant || reversal variant || turning frequency variant || backward locomotion variant