Xenopus ANatomical entity (XAN): ectoderm

(show info)

Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: XA Hierarchy (Xenopus anatomy and development from Xenbase frog anatomy ontology)

Shortest distance to current term (+ for parents, - for children) XA term [XA ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + + 4: anatomical structure [XAO:0003000] <11> (577|733) (577|400|163)

+ + + + 4: whole organism [XAO:0003004] <12> (461|598) (465|335|145)

+ + + 3: multicellular anatomical structure [XAO:0005002] <4> (436|565) (440|325|142)

+ + + 3: Xenopus anatomical entity [XAO:0000000] <9>

+ + 2: tissue [XAO:0003040] <186> (182|250) (189|130|58)

+ + 2: embryo [XAO:0000113] <8> (134|185) (134|89|38)

+ 1: primary germ layer [XAO:0003011] <4> (109|155) (109|73|30)

0: ectoderm [XAO:0000001] <15> (62|85) (62|43|11)

- 1: epidermis [XAO:0000028] <10> (3|6) (3|2|0)

- 1: fin [XAO:0000002] <9> (8|8) (9|1|2)

- 1: neuroectoderm [XAO:0000042] <9> (27|31) (27|15|5)

- 1: animal cap [XAO:0000036] <2> (1|1) (1|1|0)

- 1: cranial placode [XAO:0000305] <2> (12|14) (12|6|2)

- 1: mouth primordium [XAO:0000269] <2> (3|3) (3|0|0)

- 1: neural plate border [XAO:0004104] <2> (5|6) (6|2|0)

- 1: non-neural ectoderm [XAO:0004091] <2> (3|3) (3|1|0)

- 1: hatching gland [XAO:0000034] <1> (0|0) (0|0|0)

- 1: ectodermal cell [XAO:0003245] (0|0) (0|0|0)

- 1: hypophyseal primordium [XAO:0000267] (0|1) (0|0|0)

- 1: non-involuting marginal zone [XAO:0000253] (1|1) (1|2|1)

- 1: sensorial layer [XAO:0000320] (2|2) (2|0|0)

- 1: stomodeal-hypophyseal primordium [XAO:0000032] (3|3) (3|1|0)

- 1: trunk placode [XAO:0000461] (0|0) (0|0|0)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)

SCOP term	FDR (all)	Annotation (direct or inherited)
Nucleoplasmin-like core domain	0	Direct
C-terminal domain of adenylylcyclase associated protein	0	Direct
PAH2 domain	0	Direct
RBP11-like subunits of RNA polymerase	0	Direct
Synuclein	0	Direct
E2F-DP heterodimerization region	0	Direct
F1F0 ATP synthase subunit C	0	Direct
Tim10-like	0	Direct
Subdomain of clathrin and coatomer appendage domain	0	Direct
Moesin tail domain	0	Direct
GINS helical bundle-like	0	Direct
PriA/YqbF domain	0	Direct
alpha-catenin/vinculin-like	0	Direct
Ribulose-phoshate binding barrel	0	Direct
Zn-binding ribosomal proteins	0	Direct
Subunits of heterodimeric actin filament capping protein Capz	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	Direct
PLP-binding barrel	0	Direct
Surp module (SWAP domain)	0	Direct
SPOC domain-like	0	Direct
TK C-terminal domain-like	0	Direct
SMAD MH1 domain	0	Direct
Uracil-DNA glycosylase-like	0	Direct
Hedgehog/DD-peptidase	0	Direct
Zn-finger domain of Sec23/24	0	Direct
Alanine racemase C-terminal domain-like	0	Direct
DLC	0	Direct
Nop domain	0	Direct
Notch domain	0	Direct
Ribosomal proteins L15p and L18e	0	Direct
LuxS/MPP-like metallohydrolase	0	Direct
Ribosomal protein L10-like	0	Direct
Ribosomal L27 protein-like	0	Direct
Delta-sleep-inducing peptide immunoreactive peptide	0	Direct
14-3-3 protein	0	Direct
RNA-binding domain, RBD	0.000001407	Direct
Frizzled cysteine-rich domain	0.00227	Inherited
"Winged helix" DNA-binding domain	0.00327	Inherited
Homeodomain-like	0.003506	Inherited
Tubulin C-terminal domain-like	0.004005	Inherited
Tubulin nucleotide-binding domain-like	0.01048	Inherited
HLH, helix-loop-helix DNA-binding domain	0.02078	Inherited
Orange domain-like	0.04289	Inherited
Sema domain	0.04977	Inherited
Snake toxin-like	0.05398	Inherited
Cytokine	0.13	Inherited
Intermediate filament protein, coiled coil region	0.1309	Inherited
Plexin repeat	0.1802	Inherited
beta-beta-alpha zinc fingers	0.2214	Inherited
HMG-box	0.2332	Inherited
Cyclin-like	0.3664	Inherited
Kazal-type serine protease inhibitors	0.4161	Inherited
Glucocorticoid receptor-like (DNA-binding domain)	0.5738	Inherited
TIMP-like	0.6518	Inherited
lambda repressor-like DNA-binding domains	0.7349	Inherited
Growth factor receptor domain	0.7394	Inherited
p53-like transcription factors	0.7579	Inherited
Cystine-knot cytokines	0.9129	Inherited
Kringle-like	0.9228	Inherited
Cadherin-like	0.9937	Inherited
EGF/Laminin	1	Inherited

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)

SCOP term	FDR (all)	Annotation (direct or inherited)
Hedgehog (development protein), N-terminal signaling domain	0	Direct
Ferritin	0	Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	Direct
NTF2-like	0	Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	Direct
SMAD MH1 domain	0	Direct
E2F dimerization segment	0	Direct
Cell cycle transcription factor e2f-dp	0	Direct
14-3-3 protein	0	Direct
HAT/Suf repeat	0	Direct
RUNT domain	0	Direct
Prefoldin	0	Direct
F1F0 ATP synthase subunit C	0	Direct
TRASH domain	0	Direct
Helical domain of Sec23/24	0	Direct
Zn-finger domain of Sec23/24	0	Direct
Extracellular domain of cell surface receptors	0	Direct
MPP-like	0	Direct
Alpha-adaptin ear subdomain-like	0	Direct
Notch domain	0	Direct
SIAH, seven in absentia homolog	0	Direct
DLC	0	Direct
Delta-sleep-inducing peptide immunoreactive peptide	0	Direct
Nucleoplasmin-like core domain	0	Direct
Alanine racemase-like, N-terminal domain	0	Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	Direct
SMAD domain	0	Direct
C-terminal domain of adenylylcyclase associated protein	0	Direct
Branched-chain alpha-keto acid dehydrogenase PP module	0	Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	Direct
Moesin tail domain	0	Direct
CAT-like	0	Direct
Noggin	0	Direct
Eukaryotic ODC-like	0	Direct
Tim10/DDP	0	Direct
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain	0	Direct
Ribosomal proteins L15p and L18e	0	Direct
PAH2 domain	0	Direct
alpha-catenin/vinculin	0	Direct
ECR1 N-terminal domain-like	0	Direct
P4 origin-binding domain-like	0	Direct
Pseudouridine synthase I TruA	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Ran-binding domain	0	Direct
S-adenosylhomocystein hydrolase	0	Direct
Nop domain	0	Direct
SH3BGR (SH3-binding, glutamic acid-rich protein-like)	0	Direct
Synuclein	0	Direct
Surp module (SWAP domain)	0	Direct
Polo-box duplicated region	0	Direct
NLI interacting factor-like phosphatase	0	Direct
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain	0	Direct
GDI-like N domain	0	Direct
Clathrin adaptor appendage, alpha and beta chain-specific domain	0	Direct
Canonical RBD	0.000007931	Direct
Frizzled cysteine-rich domain	0.00225	Inherited
Tubulin, GTPase domain	0.003916	Inherited
Tubulin, C-terminal domain	0.003916	Inherited
Sema domain	0.006112	Inherited
Homeodomain	0.006731	Inherited
HLH, helix-loop-helix DNA-binding domain	0.01673	Inherited
Forkhead DNA-binding domain	0.02511	Inherited
Cell cycle control phosphatase, catalytic domain	0.03452	Inherited
Hairy Orange domain	0.03935	Inherited
Intermediate filament protein, coiled coil region	0.1202	Inherited
Fibroblast growth factors (FGF)	0.1335	Inherited
LIM domain	0.1501	Inherited
Classic zinc finger, C2H2	0.1539	Inherited
Plexin repeat	0.1834	Inherited
Ephrin ectodomain	0.1896	Inherited
Arginine methyltransferase	0.1896	Inherited
HMG-box	0.2107	Inherited
POU-specific domain	0.2203	Inherited
Ephrin receptor ligand binding domain	0.2317	Inherited
Glutathione peroxidase-like	0.2566	Inherited
Cyclin	0.2584	Inherited
Ovomucoid domain III-like	0.4066	Inherited
Growth factor receptor domain	0.4714	Inherited
ets domain	0.552	Inherited
Multidrug efflux transporter AcrB transmembrane domain	0.6364	Inherited
Transforming growth factor (TGF)-beta	0.6869	Inherited
Paired domain	0.7397	Inherited
T-box	0.9831	Inherited
Calmodulin-like	1	Inherited
Kringle modules	1	Inherited

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Supra-domain (including individual superfamily)

(show details)

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Zn-binding ribosomal proteins	0	Direct
14-3-3 protein	0	Direct
Hedgehog/DD-peptidase	0	Direct
PLP-binding barrel	0	Direct
Surp module (SWAP domain)	0	Direct
Zn-finger domain of Sec23/24	0	Direct
LuxS/MPP-like metallohydrolase	0	Direct
Nop domain	0	Direct
F1F0 ATP synthase subunit C	0	Direct
Synuclein	0	Direct
SPOC domain-like	0	Direct
Nucleoplasmin-like core domain	0	Direct
TK C-terminal domain-like	0	Direct
Subdomain of clathrin and coatomer appendage domain	0	Direct
GINS helical bundle-like	0	Direct
SMAD MH1 domain	0	Direct
Moesin tail domain	0	Direct
E2F-DP heterodimerization region	0	Direct
DLC	0	Direct
alpha-catenin/vinculin-like	0	Direct
Subunits of heterodimeric actin filament capping protein Capz	0	Direct
Uracil-DNA glycosylase-like	0	Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	Direct
Ribosomal L27 protein-like	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Ribosomal proteins L15p and L18e	0	Direct
PAH2 domain	0	Direct
RBP11-like subunits of RNA polymerase	0	Direct
Tim10-like	0	Direct
Ribosomal protein L10-like	0	Direct
C-terminal domain of adenylylcyclase associated protein	0	Direct
Ribulose-phoshate binding barrel	0	Direct
Alanine racemase C-terminal domain-like	0	Direct
PriA/YqbF domain	0	Direct
Notch domain	0	Direct
Delta-sleep-inducing peptide immunoreactive peptide	0	Direct
RNA-binding domain, RBD	0.000001003	Direct
Frizzled cysteine-rich domain	0.00174	Inherited
"Winged helix" DNA-binding domain	0.002515	Inherited
Homeodomain-like	0.002697	Inherited
Tubulin C-terminal domain-like	0.00309	Inherited
Tubulin nucleotide-binding domain-like	0.008222	Inherited
HLH, helix-loop-helix DNA-binding domain	0.01649	Inherited
Orange domain-like	0.03506	Inherited
Sema domain	0.04088	Inherited
Snake toxin-like	0.04441	Inherited
Cytokine	0.1121	Inherited
Intermediate filament protein, coiled coil region	0.113	Inherited
Plexin repeat	0.1581	Inherited
beta-beta-alpha zinc fingers	0.1968	Inherited
HMG-box	0.2079	Inherited
Cyclin-like	0.3354	Inherited
Kazal-type serine protease inhibitors	0.3837	Inherited
Glucocorticoid receptor-like (DNA-binding domain)	0.5376	Inherited
TIMP-like	0.6158	Inherited
lambda repressor-like DNA-binding domains	0.6999	Inherited
Growth factor receptor domain	0.7045	Inherited
p53-like transcription factors	0.7232	Inherited
Cystine-knot cytokines	0.8848	Inherited
Kringle-like	0.8949	Inherited
Cadherin-like	0.9686	Inherited
EGF/Laminin	1	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
52540,53254 52540 - P-loop containing nucleoside triphosphate hydrolases 53254 - Phosphoglycerate mutase-like	0	Direct
49348,55711 49348 - Clathrin adaptor appendage domain 55711 - Subdomain of clathrin and coatomer appendage domain	0	Direct
63411,63411 63411 - LuxS/MPP-like metallohydrolase 63411 - LuxS/MPP-like metallohydrolase	0	Direct
110324,50249 110324 - Ribosomal L27 protein-like 50249 - Nucleic acid-binding proteins	0	Direct
51419,50621 51419 - PLP-binding barrel 50621 - Alanine racemase C-terminal domain-like	0	Direct
57756,57756 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains	0	Direct
52518,52922 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52922 - TK C-terminal domain-like	0	Direct
51230,47005 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	Direct
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
52518,52518 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52518 - Thiamin diphosphate-binding fold (THDP-binding)	0	Direct
57196,90193 57196 - EGF/Laminin 90193 - Notch domain	0	Direct
82615,82615 82615 - Polo-box domain 82615 - Polo-box domain	0	Direct
57184,49265 57184 - Growth factor receptor domain 49265 - Fibronectin type III	0	Direct
47005,52777 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases	0	Direct
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains	0	Direct
52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain	0	Direct
47095,47095 47095 - HMG-box 47095 - HMG-box	0	Direct
47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like	0	Direct
54534,54534 54534 - FKBP-like 54534 - FKBP-like	0	Direct
48371,46785 48371 - ARM repeat 46785 - "Winged helix" DNA-binding domain	0	Direct
57184,100895 57184 - Growth factor receptor domain 100895 - Kazal-type serine protease inhibitors	0	Direct
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region	0	Direct
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like	0	Direct
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD	0.0008475	Direct
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like	0.00309	Inherited
103575,48726 103575 - Plexin repeat 48726 - Immunoglobulin	0.01575	Inherited
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.02484	Inherited
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like	0.03506	Inherited
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like	0.03922	Inherited
101912,103575 101912 - Sema domain 103575 - Plexin repeat	0.04088	Inherited
63501,50242 63501 - Frizzled cysteine-rich domain 50242 - TIMP-like	0.06076	Inherited
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like)	0.06076	Inherited
57603,57603 57603 - FnI-like domain 57603 - FnI-like domain	0.06184	Inherited
64593,64593 64593 - Intermediate filament protein, coiled coil region 64593 - Intermediate filament protein, coiled coil region	0.1154	Inherited
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers	0.1798	Inherited
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.2175	Inherited
56112,47769 56112 - Protein kinase-like (PK-like) 47769 - SAM/Pointed domain	0.3213	Inherited
57440,57440 57440 - Kringle-like 57440 - Kringle-like	0.3213	Inherited
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like	0.5571	Inherited
50044,55550 50044 - SH3-domain 55550 - SH2 domain	0.6576	Inherited
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.8401	Inherited
81383,52047 81383 - F-box domain 52047 - RNI-like	0.8487	Inherited
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like	0.9766	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
54791,54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I)	0	Direct
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain	0	Direct
47220,47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like	0	Direct
50249,50249,50249 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins	0	Direct
51230,47005,52777 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases	0	Direct
101912,103575,48726 101912 - Sema domain 103575 - Plexin repeat 48726 - Immunoglobulin	0.01575	Inherited
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.01927	Inherited
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.08832	Inherited
48371,48371,48371 48371 - ARM repeat 48371 - ARM repeat 48371 - ARM repeat	0.4733	Inherited
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.7546	Inherited
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like	0.8856	Inherited

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Xenopus ANatomical entity (XAN): ectoderm

Superfamily

Family

Supra-domain (including individual superfamily)