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Xenopus ANatomical entity (XAN): urogenital system
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: XA Hierarchy (Xenopus anatomy and development from Xenbase frog anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this XA term (SDXA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| ClpS-like | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| Nucleoplasmin-like core domain | 0 | DIRECT |
| SCP-like | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Cytochrome b5-like heme/steroid binding domain | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| Band 7/SPFH domain | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| Sec63 N-terminal domain-like | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| ThrRS/AlaRS common domain | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Sialidases | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| USP8 N-terminal domain-like | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| KA1-like | 0 | DIRECT |
| Six-hairpin glycosidases | 0 | DIRECT |
| DNA-binding domain | 0 | DIRECT |
| MIT domain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Eferin C-derminal domain-like | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| C-terminal domain of PLC-beta | 0 | DIRECT |
| NagB/RpiA/CoA transferase-like | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
| RNase III domain-like | 0 | DIRECT |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| L27 domain | 0 | DIRECT |
| Ran binding protein zinc finger-like | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| post-AAA+ oligomerization domain-like | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| RGC domain-like | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Mediator hinge subcomplex-like | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| NAP-like | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
| GINS helical bundle-like | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Calcium-dependent phosphotriesterase | 0 | DIRECT |
| Endosomal sorting complex assembly domain | 0 | DIRECT |
| Mib/herc2 domain-like | 0 | DIRECT |
| FabD/lysophospholipase-like | 0 | DIRECT |
| Transcription factor IIA (TFIIA), beta-barrel domain | 0 | DIRECT |
| DUSP-like | 0 | DIRECT |
| PriA/YqbF domain | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| Glycoside hydrolase/deacetylase | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| S15/NS1 RNA-binding domain | 0 | DIRECT |
| Elongation factor TFIIS domain 2 | 0 | DIRECT |
| Cysteine alpha-hairpin motif | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | DIRECT |
| ACP-like | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| Mss4-like | 0 | DIRECT |
| DNA clamp | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| DNA polymerase beta, N-terminal domain-like | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Oxysterol-binding protein-like | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| Cytidine deaminase-like | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| Ribonuclease PH domain 2-like | 0 | DIRECT |
| Galactose mutarotase-like | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| PAP/OAS1 substrate-binding domain | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| Glutamine synthetase/guanido kinase | 0 | DIRECT |
| Supernatant protein factor (SPF), C-terminal domain | 0 | DIRECT |
| Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
| TGS-like | 0 | DIRECT |
| Zinc beta-ribbon | 0 | DIRECT |
| THUMP domain-like | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| GAT-like domain | 0 | DIRECT |
| PK beta-barrel domain-like | 0 | DIRECT |
| Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
| LexA/Signal peptidase | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| The spindle assembly checkpoint protein mad2 | 0 | DIRECT |
| HRDC-like | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | DIRECT |
| FAD-binding/transporter-associated domain-like | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| PapD-like | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| Cation efflux protein transmembrane domain-like | 0 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
| Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| BSD domain-like | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| Enolase C-terminal domain-like | 0 | DIRECT |
| DLC | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Ribosomal proteins L15p and L18e | 0 | DIRECT |
| LuxS/MPP-like metallohydrolase | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
| Transcription factor IIA (TFIIA), alpha-helical domain | 0 | DIRECT |
| PEBP-like | 0 | DIRECT |
| WD40 repeat-like | 0.000000003789 | DIRECT |
| ARM repeat | 0.000000004775 | DIRECT |
| RNA-binding domain, RBD | 0.000001145 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0.0003548 | DIRECT |
| Nucleic acid-binding proteins | 0.0006801 | DIRECT |
| Ribonuclease H-like | 0.0007411 | DIRECT |
| UBC-like | 0.00192 | INHERITED FROM: egg |
| Tudor/PWWP/MBT | 0.004289 | INHERITED FROM: genital system || male genitalia || testis |
| Cyclin-like | 0.009452 | INHERITED FROM: egg |
| Sm-like ribonucleoproteins | 0.03383 | INHERITED FROM: egg || gamete |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.04179 | INHERITED FROM: egg |
| FYVE/PHD zinc finger | 0.04785 | INHERITED FROM: testis |
| Thioredoxin-like | 0.143 | INHERITED FROM: early proximal tubule |
| ARID-like | 0.1891 | INHERITED FROM: pronephric tubule |
| Translation proteins | 0.2507 | INHERITED FROM: ovary || female genitalia || primary oogonium || primary spermatogonium |
| Orange domain-like | 0.2686 | INHERITED FROM: embryonic kidney |
| Clavaminate synthase-like | 0.2809 | INHERITED FROM: late proximal tubule || late distal tubule |
| Growth factor receptor domain | 0.9202 | INHERITED FROM: urinary system |
| lambda repressor-like DNA-binding domains | 0.9893 | INHERITED FROM: pronephric tubule || late distal tubule || proximal tubule || early distal tubule || distal tubule |
| Homeodomain-like | 1 | INHERITED FROM: embryonic kidney || pronephric tubule || late proximal tubule || pronephric nephron || early proximal tubule || mesonephric duct || late distal tubule || pronephric duct || proximal tubule || early distal tubule || distal tubule || proximal tubule branch |
| TSP-1 type 1 repeat | 1 | INHERITED FROM: rectal diverticulum |
| Metalloproteases ("zincins"), catalytic domain | 1 | INHERITED FROM: rectal diverticulum |
| HLH, helix-loop-helix DNA-binding domain | 1 | INHERITED FROM: embryonic kidney |
| Frizzled cysteine-rich domain | 1 | INHERITED FROM: embryonic kidney |
| Glucocorticoid receptor-like (DNA-binding domain) | 1 | INHERITED FROM: proximal tubule branch |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| ClpS-like | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| Nucleoplasmin-like core domain | 0 | Direct |
| SCP-like | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Cytochrome b5-like heme/steroid binding domain | 0 | Direct |
| LysM domain | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| Band 7/SPFH domain | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| Sec63 N-terminal domain-like | 0 | Direct |
| Enolase N-terminal domain-like | 0 | Direct |
| PAH2 domain | 0 | Direct |
| LDH C-terminal domain-like | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| ThrRS/AlaRS common domain | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Sialidases | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| USP8 N-terminal domain-like | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| KA1-like | 0 | Direct |
| Six-hairpin glycosidases | 0 | Direct |
| DNA-binding domain | 0 | Direct |
| MIT domain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Eferin C-derminal domain-like | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Tim10-like | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| C-terminal domain of PLC-beta | 0 | Direct |
| NagB/RpiA/CoA transferase-like | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Families 57/38 glycoside transferase middle domain | 0 | Direct |
| RNase III domain-like | 0 | Direct |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| NTF2-like | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| L27 domain | 0 | Direct |
| Ran binding protein zinc finger-like | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| post-AAA+ oligomerization domain-like | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| RGC domain-like | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Mediator hinge subcomplex-like | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| NAP-like | 0 | Direct |
| LeuD/IlvD-like | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
| GINS helical bundle-like | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Calcium-dependent phosphotriesterase | 0 | Direct |
| Endosomal sorting complex assembly domain | 0 | Direct |
| Mib/herc2 domain-like | 0 | Direct |
| FabD/lysophospholipase-like | 0 | Direct |
| Transcription factor IIA (TFIIA), beta-barrel domain | 0 | Direct |
| DUSP-like | 0 | Direct |
| PriA/YqbF domain | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| Glycoside hydrolase/deacetylase | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| S15/NS1 RNA-binding domain | 0 | Direct |
| Elongation factor TFIIS domain 2 | 0 | Direct |
| Cysteine alpha-hairpin motif | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | Direct |
| ACP-like | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| Mss4-like | 0 | Direct |
| DNA clamp | 0 | Direct |
| Translational machinery components | 0 | Direct |
| DNA polymerase beta, N-terminal domain-like | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Oxysterol-binding protein-like | 0 | Direct |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
| Cytidine deaminase-like | 0 | Direct |
| FAS1 domain | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| Ribonuclease PH domain 2-like | 0 | Direct |
| Galactose mutarotase-like | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| PAP/OAS1 substrate-binding domain | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| FF domain | 0 | Direct |
| Glutamine synthetase/guanido kinase | 0 | Direct |
| Supernatant protein factor (SPF), C-terminal domain | 0 | Direct |
| Nucleoside diphosphate kinase, NDK | 0 | Direct |
| TGS-like | 0 | Direct |
| Zinc beta-ribbon | 0 | Direct |
| THUMP domain-like | 0 | Direct |
| WGR domain-like | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| TSP type-3 repeat | 0 | Direct |
| GAT-like domain | 0 | Direct |
| PK beta-barrel domain-like | 0 | Direct |
| Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
| LexA/Signal peptidase | 0 | Direct |
| Connexin43 | 0 | Direct |
| The spindle assembly checkpoint protein mad2 | 0 | Direct |
| HRDC-like | 0 | Direct |
| SIS domain | 0 | Direct |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | Direct |
| FAD-binding/transporter-associated domain-like | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| Tricorn protease domain 2 | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| PapD-like | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| Cation efflux protein transmembrane domain-like | 0 | Direct |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
| Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| BSD domain-like | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| GYF domain | 0 | Direct |
| ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| Enolase C-terminal domain-like | 0 | Direct |
| DLC | 0 | Direct |
| Nop domain | 0 | Direct |
| Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| Notch domain | 0 | Direct |
| Ribosomal proteins L15p and L18e | 0 | Direct |
| LuxS/MPP-like metallohydrolase | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
| Transcription factor IIA (TFIIA), alpha-helical domain | 0 | Direct |
| PEBP-like | 0 | Direct |
| WD40 repeat-like | 0.000000003789 | Direct |
| ARM repeat | 0.000000004775 | Direct |
| RNA-binding domain, RBD | 0.000001145 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0.0003548 | Direct |
| Nucleic acid-binding proteins | 0.0006801 | Direct |
| Ribonuclease H-like | 0.0007411 | Direct |
| UBC-like | 0.00192 | Inherited |
| Tudor/PWWP/MBT | 0.004289 | Inherited |
| Cyclin-like | 0.009452 | Inherited |
| Sm-like ribonucleoproteins | 0.03383 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.04179 | Inherited |
| FYVE/PHD zinc finger | 0.04785 | Inherited |
| Thioredoxin-like | 0.143 | Inherited |
| ARID-like | 0.1891 | Inherited |
| Translation proteins | 0.2507 | Inherited |
| Orange domain-like | 0.2686 | Inherited |
| Clavaminate synthase-like | 0.2809 | Inherited |
| Growth factor receptor domain | 0.9202 | Inherited |
| lambda repressor-like DNA-binding domains | 0.9893 | Inherited |
| Homeodomain-like | 1 | Inherited |
| TSP-1 type 1 repeat | 1 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 1 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 1 | Inherited |
| Frizzled cysteine-rich domain | 1 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this XA term (SDXA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Ubiquitin activating enzymes (UBA) | 0 | DIRECT |
| RGC domain | 0 | DIRECT |
| Translation initiation factor eIF4e | 0 | DIRECT |
| Ferritin | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | DIRECT |
| Trunk domain of Sec23/24 | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | DIRECT |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | DIRECT |
| LeuD-like | 0 | DIRECT |
| MIF4G domain-like | 0 | DIRECT |
| Pumilio repeat | 0 | DIRECT |
| RNA-polymerase beta | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| APC10-like | 0 | DIRECT |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
| Cation efflux protein transmembrane domain-like | 0 | DIRECT |
| Deoxycytidylate deaminase-like | 0 | DIRECT |
| Anticodon-binding domain | 0 | DIRECT |
| UDP-glucose pyrophosphorylase | 0 | DIRECT |
| DNA polymerase beta, N-terminal domain-like | 0 | DIRECT |
| LDH N-terminal domain-like | 0 | DIRECT |
| Mib/herc2 domain | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | DIRECT |
| Adenain-like | 0 | DIRECT |
| Eferin C-derminal domain-like | 0 | DIRECT |
| p120GAP domain-like | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| Phosphatidylethanolamine binding protein | 0 | DIRECT |
| MutT-like | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| E2F dimerization segment | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| alpha-mannosidase | 0 | DIRECT |
| Myb/SANT domain | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| HD domain | 0 | DIRECT |
| Arginase-like amidino hydrolases | 0 | DIRECT |
| Cytochrome b5 | 0 | DIRECT |
| Thrombospondin C-terminal domain | 0 | DIRECT |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
| Protein-L-isoaspartyl O-methyltransferase | 0 | DIRECT |
| GS domain | 0 | DIRECT |
| Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
| CAD domain | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| Glucose 6-phosphate dehydrogenase-like | 0 | DIRECT |
| Crotonase-like | 0 | DIRECT |
| TBP-associated factors, TAFs | 0 | DIRECT |
| HAT/Suf repeat | 0 | DIRECT |
| Fumble-like | 0 | DIRECT |
| Methyl-CpG-binding domain, MBD | 0 | DIRECT |
| Sir2 family of transcriptional regulators | 0 | DIRECT |
| NagB-like | 0 | DIRECT |
| DUSP, domain in ubiquitin-specific proteases | 0 | DIRECT |
| DNA polymerase III clamp loader subunits, C-terminal domain | 0 | DIRECT |
| L27 domain | 0 | DIRECT |
| gamma-adaptin C-terminal appendage domain-like | 0 | DIRECT |
| Guanido kinase catalytic domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| TRASH domain | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| NIPSNAP | 0 | DIRECT |
| DNA ligase | 0 | DIRECT |
| Transcription factor IIA (TFIIA), beta-barrel domain | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Glycosyl transferases group 1 | 0 | DIRECT |
| MPP-like | 0 | DIRECT |
| Fibronectin type I module | 0 | DIRECT |
| Alpha-adaptin ear subdomain-like | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | DIRECT |
| IF2B-like | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| BC C-terminal domain-like | 0 | DIRECT |
| VHS domain | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| SIAH, seven in absentia homolog | 0 | DIRECT |
| L30e/L7ae ribosomal proteins | 0 | DIRECT |
| Sedlin (SEDL) | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | DIRECT |
| (Glycosyl)asparaginase | 0 | DIRECT |
| LON domain-like | 0 | DIRECT |
| ATP-dependent DNA ligase catalytic domain | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| MSP-like | 0 | DIRECT |
| DLC | 0 | DIRECT |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| Variant RING domain | 0 | DIRECT |
| U-box | 0 | DIRECT |
| MIT domain | 0 | DIRECT |
| alpha-mannosidase, domain 2 | 0 | DIRECT |
| Nucleoplasmin-like core domain | 0 | DIRECT |
| Protein serine/threonine phosphatase | 0 | DIRECT |
| F-box associated region, FBA | 0 | DIRECT |
| Sterol carrier protein, SCP | 0 | DIRECT |
| Alanine racemase-like, N-terminal domain | 0 | DIRECT |
| RPR domain (SMART 00582 ) | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| GAT domain | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Transcriptional factor domain | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| Class II glutamine amidotransferases | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| USP8 N-terminal domain-like | 0 | DIRECT |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| ZZ domain | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| WGR domain | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| CAT-like | 0 | DIRECT |
| Outer arm dynein light chain 1 | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | DIRECT |
| C-terminal domain of PLC-beta | 0 | DIRECT |
| Zf-UBP | 0 | DIRECT |
| Eukaryotic ODC-like | 0 | DIRECT |
| Elongation factor TFIIS domain 2 | 0 | DIRECT |
| TATA-box binding protein (TBP), C-terminal domain | 0 | DIRECT |
| Tim10/DDP | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| NAP-like | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| 5' nucleotidase-like | 0 | DIRECT |
| 4HBT-like | 0 | DIRECT |
| Ribosomal proteins L15p and L18e | 0 | DIRECT |
| SEA domain | 0 | DIRECT |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0 | DIRECT |
| alpha-mannosidase, C-terminal domain | 0 | DIRECT |
| Band 7/SPFH domain | 0 | DIRECT |
| Carboxylesterase/thioesterase 1 | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| Protein prenyltransferases | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| alpha-catenin/vinculin | 0 | DIRECT |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | DIRECT |
| A20-like zinc finger | 0 | DIRECT |
| SCF ubiquitin ligase complex WHB domain | 0 | DIRECT |
| Neutral endopeptidase (neprilysin) | 0 | DIRECT |
| Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | DIRECT |
| ECR1 N-terminal domain-like | 0 | DIRECT |
| Ran binding protein zinc finger-like | 0 | DIRECT |
| Ribosomal protein L18 and S11 | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| Ribonuclease PH domain 1-like | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| UBX domain | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Pseudouridine synthase I TruA | 0 | DIRECT |
| Threonyl-tRNA synthetase (ThrRS), second 'additional' domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| BSD domain | 0 | DIRECT |
| Malic enzyme N-domain | 0 | DIRECT |
| Phosphoribosylpyrophosphate synthetase-like | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| Ribonuclease PH domain 2-like | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Steroid-binding domain | 0 | DIRECT |
| Ran-binding domain | 0 | DIRECT |
| S-adenosylhomocystein hydrolase | 0 | DIRECT |
| DJ-1/PfpI | 0 | DIRECT |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0 | DIRECT |
| Transferrin | 0 | DIRECT |
| Kinase associated domain 1, KA1 | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| Cytidylyltransferase | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Supernatant protein factor (SPF), C-terminal domain | 0 | DIRECT |
| Exostosin | 0 | DIRECT |
| a tRNA synthase domain | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| Transcription factor IIA (TFIIA), alpha-helical domain | 0 | DIRECT |
| Polo-box duplicated region | 0 | DIRECT |
| Cystathionine synthase-like | 0 | DIRECT |
| Serine carboxypeptidase-like | 0 | DIRECT |
| Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
| GDI-like N domain | 0 | DIRECT |
| XPF/Rad1/Mus81 nuclease | 0 | DIRECT |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | DIRECT |
| B56-like | 0 | DIRECT |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
| La domain | 0 | DIRECT |
| Oxysterol-binding protein | 0 | DIRECT |
| HEAT repeat | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| WD40-repeat | 0.00000004525 | DIRECT |
| Canonical RBD | 0.00000707 | DIRECT |
| Tandem AAA-ATPase domain | 0.0005662 | DIRECT |
| UBC-related | 0.001812 | INHERITED FROM: egg || gamete |
| Extended AAA-ATPase domain | 0.00208 | INHERITED FROM: genital system || testis |
| Cyclin | 0.003647 | INHERITED FROM: egg || genital system |
| PHD domain | 0.01541 | INHERITED FROM: testis |
| Cold shock DNA-binding domain-like | 0.0394 | INHERITED FROM: egg |
| Nitrogenase iron protein-like | 0.06701 | INHERITED FROM: male genitalia || testis |
| Laminin G-like module | 0.08301 | INHERITED FROM: ovary || female genitalia |
| Tudor domain | 0.1017 | INHERITED FROM: egg |
| G proteins | 0.1491 | INHERITED FROM: primary oogonium || primary spermatogonium |
| ARID domain | 0.1516 | INHERITED FROM: pronephric tubule |
| Elongation factors | 0.2208 | INHERITED FROM: ovary || female genitalia || primary oogonium || primary spermatogonium |
| Hairy Orange domain | 0.2263 | INHERITED FROM: embryonic kidney |
| AAT-like | 0.2263 | INHERITED FROM: pronephric duct |
| Glutathione peroxidase-like | 0.2645 | INHERITED FROM: embryonic kidney || pronephric tubule || pronephric nephron || early proximal tubule || proximal tubule || early distal tubule || distal tubule |
| ets domain | 0.4145 | INHERITED FROM: urinary system |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.6887 | INHERITED FROM: pronephric tubule || pronephric nephron || kidney |
| Class I aldolase | 0.7201 | INHERITED FROM: embryonic kidney || pronephric kidney |
| POU-specific domain | 0.9266 | INHERITED FROM: pronephric tubule || late distal tubule || pronephric duct || proximal tubule || early distal tubule || distal tubule |
| Homeodomain | 1 | INHERITED FROM: embryonic kidney || pronephric tubule || late proximal tubule || pronephric nephron || early proximal tubule || late distal tubule || pronephric duct || proximal tubule || early distal tubule || distal tubule || proximal tubule branch |
| TSP-1 type 1 repeat | 1 | INHERITED FROM: rectal diverticulum |
| Frizzled cysteine-rich domain | 1 | INHERITED FROM: embryonic kidney |
| Transforming growth factor (TGF)-beta | 1 | INHERITED FROM: early distal tubule |
| HLH, helix-loop-helix DNA-binding domain | 1 | INHERITED FROM: embryonic kidney |
| Forkhead DNA-binding domain | 1 | INHERITED FROM: pronephric nephrostome |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Ubiquitin activating enzymes (UBA) | 0 | Direct |
| RGC domain | 0 | Direct |
| Translation initiation factor eIF4e | 0 | Direct |
| Ferritin | 0 | Direct |
| Enolase N-terminal domain-like | 0 | Direct |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | Direct |
| Trunk domain of Sec23/24 | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | Direct |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | Direct |
| LeuD-like | 0 | Direct |
| MIF4G domain-like | 0 | Direct |
| Pumilio repeat | 0 | Direct |
| RNA-polymerase beta | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| APC10-like | 0 | Direct |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
| Cation efflux protein transmembrane domain-like | 0 | Direct |
| Deoxycytidylate deaminase-like | 0 | Direct |
| Anticodon-binding domain | 0 | Direct |
| UDP-glucose pyrophosphorylase | 0 | Direct |
| DNA polymerase beta, N-terminal domain-like | 0 | Direct |
| LDH N-terminal domain-like | 0 | Direct |
| Mib/herc2 domain | 0 | Direct |
| NTF2-like | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | Direct |
| Adenain-like | 0 | Direct |
| Eferin C-derminal domain-like | 0 | Direct |
| p120GAP domain-like | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| Phosphatidylethanolamine binding protein | 0 | Direct |
| MutT-like | 0 | Direct |
| FAS1 domain | 0 | Direct |
| E2F dimerization segment | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| alpha-mannosidase | 0 | Direct |
| Myb/SANT domain | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| HD domain | 0 | Direct |
| Arginase-like amidino hydrolases | 0 | Direct |
| Cytochrome b5 | 0 | Direct |
| Thrombospondin C-terminal domain | 0 | Direct |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
| Protein-L-isoaspartyl O-methyltransferase | 0 | Direct |
| GS domain | 0 | Direct |
| Nucleoside diphosphate kinase, NDK | 0 | Direct |
| CAD domain | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| Glucose 6-phosphate dehydrogenase-like | 0 | Direct |
| Crotonase-like | 0 | Direct |
| TBP-associated factors, TAFs | 0 | Direct |
| HAT/Suf repeat | 0 | Direct |
| Fumble-like | 0 | Direct |
| Methyl-CpG-binding domain, MBD | 0 | Direct |
| Sir2 family of transcriptional regulators | 0 | Direct |
| NagB-like | 0 | Direct |
| DUSP, domain in ubiquitin-specific proteases | 0 | Direct |
| DNA polymerase III clamp loader subunits, C-terminal domain | 0 | Direct |
| L27 domain | 0 | Direct |
| gamma-adaptin C-terminal appendage domain-like | 0 | Direct |
| Guanido kinase catalytic domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| TRASH domain | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| NIPSNAP | 0 | Direct |
| DNA ligase | 0 | Direct |
| Transcription factor IIA (TFIIA), beta-barrel domain | 0 | Direct |
| Translational machinery components | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Glycosyl transferases group 1 | 0 | Direct |
| MPP-like | 0 | Direct |
| Fibronectin type I module | 0 | Direct |
| Alpha-adaptin ear subdomain-like | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | Direct |
| IF2B-like | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| BC C-terminal domain-like | 0 | Direct |
| VHS domain | 0 | Direct |
| Notch domain | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| SIAH, seven in absentia homolog | 0 | Direct |
| L30e/L7ae ribosomal proteins | 0 | Direct |
| Sedlin (SEDL) | 0 | Direct |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | Direct |
| (Glycosyl)asparaginase | 0 | Direct |
| LON domain-like | 0 | Direct |
| ATP-dependent DNA ligase catalytic domain | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| MSP-like | 0 | Direct |
| DLC | 0 | Direct |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| Variant RING domain | 0 | Direct |
| U-box | 0 | Direct |
| MIT domain | 0 | Direct |
| alpha-mannosidase, domain 2 | 0 | Direct |
| Nucleoplasmin-like core domain | 0 | Direct |
| Protein serine/threonine phosphatase | 0 | Direct |
| F-box associated region, FBA | 0 | Direct |
| Sterol carrier protein, SCP | 0 | Direct |
| Alanine racemase-like, N-terminal domain | 0 | Direct |
| RPR domain (SMART 00582 ) | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| GAT domain | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Transcriptional factor domain | 0 | Direct |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| Class II glutamine amidotransferases | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| USP8 N-terminal domain-like | 0 | Direct |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| ZZ domain | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| WGR domain | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| CAT-like | 0 | Direct |
| Outer arm dynein light chain 1 | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | Direct |
| C-terminal domain of PLC-beta | 0 | Direct |
| Zf-UBP | 0 | Direct |
| Eukaryotic ODC-like | 0 | Direct |
| Elongation factor TFIIS domain 2 | 0 | Direct |
| TATA-box binding protein (TBP), C-terminal domain | 0 | Direct |
| Tim10/DDP | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| NAP-like | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| 5' nucleotidase-like | 0 | Direct |
| 4HBT-like | 0 | Direct |
| Ribosomal proteins L15p and L18e | 0 | Direct |
| SEA domain | 0 | Direct |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0 | Direct |
| alpha-mannosidase, C-terminal domain | 0 | Direct |
| Band 7/SPFH domain | 0 | Direct |
| Carboxylesterase/thioesterase 1 | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | Direct |
| Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| Protein prenyltransferases | 0 | Direct |
| PAH2 domain | 0 | Direct |
| alpha-catenin/vinculin | 0 | Direct |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| Lactate & malate dehydrogenases, C-terminal domain | 0 | Direct |
| A20-like zinc finger | 0 | Direct |
| SCF ubiquitin ligase complex WHB domain | 0 | Direct |
| Neutral endopeptidase (neprilysin) | 0 | Direct |
| Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | Direct |
| ECR1 N-terminal domain-like | 0 | Direct |
| Ran binding protein zinc finger-like | 0 | Direct |
| Ribosomal protein L18 and S11 | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| Ribonuclease PH domain 1-like | 0 | Direct |
| Connexin43 | 0 | Direct |
| UBX domain | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Pseudouridine synthase I TruA | 0 | Direct |
| Threonyl-tRNA synthetase (ThrRS), second 'additional' domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| BSD domain | 0 | Direct |
| Malic enzyme N-domain | 0 | Direct |
| Phosphoribosylpyrophosphate synthetase-like | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| Ribonuclease PH domain 2-like | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Steroid-binding domain | 0 | Direct |
| Ran-binding domain | 0 | Direct |
| S-adenosylhomocystein hydrolase | 0 | Direct |
| DJ-1/PfpI | 0 | Direct |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0 | Direct |
| Transferrin | 0 | Direct |
| Kinase associated domain 1, KA1 | 0 | Direct |
| Nop domain | 0 | Direct |
| LysM domain | 0 | Direct |
| Cytidylyltransferase | 0 | Direct |
| TSP type-3 repeat | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Supernatant protein factor (SPF), C-terminal domain | 0 | Direct |
| Exostosin | 0 | Direct |
| a tRNA synthase domain | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| Cullin repeat | 0 | Direct |
| Transcription factor IIA (TFIIA), alpha-helical domain | 0 | Direct |
| Polo-box duplicated region | 0 | Direct |
| Cystathionine synthase-like | 0 | Direct |
| Serine carboxypeptidase-like | 0 | Direct |
| Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
| GDI-like N domain | 0 | Direct |
| XPF/Rad1/Mus81 nuclease | 0 | Direct |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | Direct |
| B56-like | 0 | Direct |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
| La domain | 0 | Direct |
| Oxysterol-binding protein | 0 | Direct |
| HEAT repeat | 0 | Direct |
| FF domain | 0 | Direct |
| WD40-repeat | 0.00000004525 | Direct |
| Canonical RBD | 0.00000707 | Direct |
| Tandem AAA-ATPase domain | 0.0005662 | Direct |
| UBC-related | 0.001812 | Inherited |
| Extended AAA-ATPase domain | 0.00208 | Inherited |
| Cyclin | 0.003647 | Inherited |
| PHD domain | 0.01541 | Inherited |
| Cold shock DNA-binding domain-like | 0.0394 | Inherited |
| Nitrogenase iron protein-like | 0.06701 | Inherited |
| Laminin G-like module | 0.08301 | Inherited |
| Tudor domain | 0.1017 | Inherited |
| G proteins | 0.1491 | Inherited |
| ARID domain | 0.1516 | Inherited |
| Elongation factors | 0.2208 | Inherited |
| Hairy Orange domain | 0.2263 | Inherited |
| AAT-like | 0.2263 | Inherited |
| Glutathione peroxidase-like | 0.2645 | Inherited |
| ets domain | 0.4145 | Inherited |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.6887 | Inherited |
| Class I aldolase | 0.7201 | Inherited |
| POU-specific domain | 0.9266 | Inherited |
| Homeodomain | 1 | Inherited |
| TSP-1 type 1 repeat | 1 | Inherited |
| Frizzled cysteine-rich domain | 1 | Inherited |
| Transforming growth factor (TGF)-beta | 1 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 1 | Inherited |
| Forkhead DNA-binding domain | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this XA term (SPXA level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Endosomal sorting complex assembly domain | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| LDH C-terminal domain-like | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| DNA clamp | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| SCP-like | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| LexA/Signal peptidase | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Zinc beta-ribbon | 0 | DIRECT |
| DNA polymerase beta, N-terminal domain-like | 0 | DIRECT |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | DIRECT |
| LuxS/MPP-like metallohydrolase | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| Calcium-dependent phosphotriesterase | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| NagB/RpiA/CoA transferase-like | 0 | DIRECT |
| Mediator hinge subcomplex-like | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| Eferin C-derminal domain-like | 0 | DIRECT |
| L27 domain | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| RNase III domain-like | 0 | DIRECT |
| FabD/lysophospholipase-like | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| Sialidases | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| Mss4-like | 0 | DIRECT |
| Enolase C-terminal domain-like | 0 | DIRECT |
| PEBP-like | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Nucleoplasmin-like core domain | 0 | DIRECT |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | DIRECT |
| RGC domain-like | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Sec63 N-terminal domain-like | 0 | DIRECT |
| Cytochrome b5-like heme/steroid binding domain | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| Transcription factor IIA (TFIIA), beta-barrel domain | 0 | DIRECT |
| GINS helical bundle-like | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| MIT domain | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
| Band 7/SPFH domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| S15/NS1 RNA-binding domain | 0 | DIRECT |
| USP8 N-terminal domain-like | 0 | DIRECT |
| C-terminal domain of PLC-beta | 0 | DIRECT |
| DLC | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | DIRECT |
| post-AAA+ oligomerization domain-like | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| Oxysterol-binding protein-like | 0 | DIRECT |
| Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
| TGS-like | 0 | DIRECT |
| FAD-binding/transporter-associated domain-like | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| PapD-like | 0 | DIRECT |
| Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
| ClpS-like | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| BSD domain-like | 0 | DIRECT |
| Cytidine deaminase-like | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| THUMP domain-like | 0 | DIRECT |
| DUSP-like | 0 | DIRECT |
| Glycoside hydrolase/deacetylase | 0 | DIRECT |
| PK beta-barrel domain-like | 0 | DIRECT |
| ThrRS/AlaRS common domain | 0 | DIRECT |
| NAP-like | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
| The spindle assembly checkpoint protein mad2 | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Ribosomal proteins L15p and L18e | 0 | DIRECT |
| Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
| KA1-like | 0 | DIRECT |
| Glutamine synthetase/guanido kinase | 0 | DIRECT |
| Transcription factor IIA (TFIIA), alpha-helical domain | 0 | DIRECT |
| Ribonuclease PH domain 2-like | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| Cation efflux protein transmembrane domain-like | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| Supernatant protein factor (SPF), C-terminal domain | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| GAT-like domain | 0 | DIRECT |
| Elongation factor TFIIS domain 2 | 0 | DIRECT |
| Cysteine alpha-hairpin motif | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
| Galactose mutarotase-like | 0 | DIRECT |
| DNA-binding domain | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Mib/herc2 domain-like | 0 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
| Ran binding protein zinc finger-like | 0 | DIRECT |
| HRDC-like | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| ACP-like | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| PriA/YqbF domain | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Six-hairpin glycosidases | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
| PAP/OAS1 substrate-binding domain | 0 | DIRECT |
| WD40 repeat-like | 0.000000002651 | DIRECT |
| ARM repeat | 0.000000003342 | DIRECT |
| RNA-binding domain, RBD | 0.0000008145 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0.0002657 | DIRECT |
| Nucleic acid-binding proteins | 0.0005132 | DIRECT |
| Ribonuclease H-like | 0.0005602 | DIRECT |
| UBC-like | 0.001469 | INHERITED FROM: genital system || egg |
| Tudor/PWWP/MBT | 0.003315 | INHERITED FROM: testis || genital system || male genitalia |
| Cyclin-like | 0.007403 | INHERITED FROM: genital system || egg |
| Sm-like ribonucleoproteins | 0.02732 | INHERITED FROM: gamete || egg |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.03412 | INHERITED FROM: egg |
| FYVE/PHD zinc finger | 0.03926 | INHERITED FROM: testis |
| Thioredoxin-like | 0.1239 | INHERITED FROM: early proximal tubule |
| ARID-like | 0.1663 | INHERITED FROM: pronephric tubule |
| Translation proteins | 0.2241 | INHERITED FROM: female genitalia || primary oogonium || ovary || primary spermatogonium |
| Orange domain-like | 0.2413 | INHERITED FROM: embryonic kidney |
| Clavaminate synthase-like | 0.253 | INHERITED FROM: early proximal tubule || late distal tubule || late proximal tubule |
| Growth factor receptor domain | 0.8923 | INHERITED FROM: urinary system |
| lambda repressor-like DNA-binding domains | 0.9641 | INHERITED FROM: early distal tubule || proximal tubule || late distal tubule || distal tubule || pronephric tubule |
| HLH, helix-loop-helix DNA-binding domain | 1 | INHERITED FROM: embryonic kidney |
| TSP-1 type 1 repeat | 1 | INHERITED FROM: rectal diverticulum |
| Glucocorticoid receptor-like (DNA-binding domain) | 1 | INHERITED FROM: proximal tubule branch |
| Frizzled cysteine-rich domain | 1 | INHERITED FROM: embryonic kidney |
| Metalloproteases ("zincins"), catalytic domain | 1 | INHERITED FROM: rectal diverticulum |
| Homeodomain-like | 1 | INHERITED FROM: early proximal tubule || early distal tubule || pronephric nephron || proximal tubule || embryonic kidney || late distal tubule || distal tubule || proximal tubule branch || pronephric duct || mesonephric duct || late proximal tubule || pronephric tubule |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Endosomal sorting complex assembly domain | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| LDH C-terminal domain-like | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| DNA clamp | 0 | Direct |
| NTF2-like | 0 | Direct |
| SCP-like | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| LexA/Signal peptidase | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Zinc beta-ribbon | 0 | Direct |
| DNA polymerase beta, N-terminal domain-like | 0 | Direct |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | Direct |
| LuxS/MPP-like metallohydrolase | 0 | Direct |
| TSP type-3 repeat | 0 | Direct |
| Nop domain | 0 | Direct |
| Calcium-dependent phosphotriesterase | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| NagB/RpiA/CoA transferase-like | 0 | Direct |
| Mediator hinge subcomplex-like | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| Eferin C-derminal domain-like | 0 | Direct |
| L27 domain | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| RNase III domain-like | 0 | Direct |
| FabD/lysophospholipase-like | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| Sialidases | 0 | Direct |
| FF domain | 0 | Direct |
| Mss4-like | 0 | Direct |
| Enolase C-terminal domain-like | 0 | Direct |
| PEBP-like | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Nucleoplasmin-like core domain | 0 | Direct |
| Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| SIS domain | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | Direct |
| RGC domain-like | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Sec63 N-terminal domain-like | 0 | Direct |
| Cytochrome b5-like heme/steroid binding domain | 0 | Direct |
| Connexin43 | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| LeuD/IlvD-like | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| Transcription factor IIA (TFIIA), beta-barrel domain | 0 | Direct |
| GINS helical bundle-like | 0 | Direct |
| LysM domain | 0 | Direct |
| GYF domain | 0 | Direct |
| MIT domain | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
| Band 7/SPFH domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| S15/NS1 RNA-binding domain | 0 | Direct |
| USP8 N-terminal domain-like | 0 | Direct |
| C-terminal domain of PLC-beta | 0 | Direct |
| DLC | 0 | Direct |
| WGR domain-like | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | Direct |
| post-AAA+ oligomerization domain-like | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| Oxysterol-binding protein-like | 0 | Direct |
| Nucleoside diphosphate kinase, NDK | 0 | Direct |
| TGS-like | 0 | Direct |
| FAD-binding/transporter-associated domain-like | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| PapD-like | 0 | Direct |
| Families 57/38 glycoside transferase middle domain | 0 | Direct |
| ClpS-like | 0 | Direct |
| FAS1 domain | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| Translational machinery components | 0 | Direct |
| BSD domain-like | 0 | Direct |
| Cytidine deaminase-like | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Tricorn protease domain 2 | 0 | Direct |
| THUMP domain-like | 0 | Direct |
| DUSP-like | 0 | Direct |
| Glycoside hydrolase/deacetylase | 0 | Direct |
| PK beta-barrel domain-like | 0 | Direct |
| ThrRS/AlaRS common domain | 0 | Direct |
| NAP-like | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
| The spindle assembly checkpoint protein mad2 | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Ribosomal proteins L15p and L18e | 0 | Direct |
| Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
| KA1-like | 0 | Direct |
| Glutamine synthetase/guanido kinase | 0 | Direct |
| Transcription factor IIA (TFIIA), alpha-helical domain | 0 | Direct |
| Ribonuclease PH domain 2-like | 0 | Direct |
| PAH2 domain | 0 | Direct |
| Cation efflux protein transmembrane domain-like | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| Supernatant protein factor (SPF), C-terminal domain | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Tim10-like | 0 | Direct |
| GAT-like domain | 0 | Direct |
| Elongation factor TFIIS domain 2 | 0 | Direct |
| Cysteine alpha-hairpin motif | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
| Galactose mutarotase-like | 0 | Direct |
| DNA-binding domain | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Mib/herc2 domain-like | 0 | Direct |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
| Ran binding protein zinc finger-like | 0 | Direct |
| HRDC-like | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| Enolase N-terminal domain-like | 0 | Direct |
| ACP-like | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| PriA/YqbF domain | 0 | Direct |
| Notch domain | 0 | Direct |
| Six-hairpin glycosidases | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
| PAP/OAS1 substrate-binding domain | 0 | Direct |
| WD40 repeat-like | 0.000000002651 | Direct |
| ARM repeat | 0.000000003342 | Direct |
| RNA-binding domain, RBD | 0.0000008145 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0.0002657 | Direct |
| Nucleic acid-binding proteins | 0.0005132 | Direct |
| Ribonuclease H-like | 0.0005602 | Direct |
| UBC-like | 0.001469 | Inherited |
| Tudor/PWWP/MBT | 0.003315 | Inherited |
| Cyclin-like | 0.007403 | Inherited |
| Sm-like ribonucleoproteins | 0.02732 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 0.03412 | Inherited |
| FYVE/PHD zinc finger | 0.03926 | Inherited |
| Thioredoxin-like | 0.1239 | Inherited |
| ARID-like | 0.1663 | Inherited |
| Translation proteins | 0.2241 | Inherited |
| Orange domain-like | 0.2413 | Inherited |
| Clavaminate synthase-like | 0.253 | Inherited |
| Growth factor receptor domain | 0.8923 | Inherited |
| lambda repressor-like DNA-binding domains | 0.9641 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 1 | Inherited |
| TSP-1 type 1 repeat | 1 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 1 | Inherited |
| Frizzled cysteine-rich domain | 1 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 1 | Inherited |
| Homeodomain-like | 1 | Inherited |
(show details)
Supra-domains annotated to this XA term (SPXA level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
46585,46585
46585 - HR1 repeat
46585 - HR1 repeat | 0 | DIRECT |
103647,49899
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | DIRECT |
57184,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
88723,47807
88723 - PIN domain-like
47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
57196,100895
57196 - EGF/Laminin
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | DIRECT |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | DIRECT |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | DIRECT |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | DIRECT |
110324,50249
110324 - Ribosomal L27 protein-like
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | DIRECT |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | DIRECT |
74650,51445
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases | 0 | DIRECT |
55550,50729
55550 - SH2 domain
50729 - PH domain-like | 0 | DIRECT |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0 | DIRECT |
49899,52540
49899 - Concanavalin A-like lectins/glucanases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | DIRECT |
100895,47473
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand | 0 | DIRECT |
55945,55945
55945 - TATA-box binding protein-like
55945 - TATA-box binding protein-like | 0 | DIRECT |
101288,50156
101288 - L27 domain
50156 - PDZ domain-like | 0 | DIRECT |
51230,47005
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0 | DIRECT |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | DIRECT |
142921,47587
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
90209,90209
90209 - Ran binding protein zinc finger-like
90209 - Ran binding protein zinc finger-like | 0 | DIRECT |
56112,48371
56112 - Protein kinase-like (PK-like)
48371 - ARM repeat | 0 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0 | DIRECT |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | DIRECT |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
52425,48173
52425 - Cryptochrome/photolyase, N-terminal domain
48173 - Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0 | DIRECT |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | DIRECT |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | DIRECT |
52058,49265
52058 - L domain-like
49265 - Fibronectin type III | 0 | DIRECT |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
47005,52777
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
81995,81811
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | DIRECT |
81296,48239
81296 - E set domains
48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
49265,56496
49265 - Fibronectin type III
56496 - Fibrinogen C-terminal domain-like | 0 | DIRECT |
53300,81995
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0 | DIRECT |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
47095,47095
47095 - HMG-box
47095 - HMG-box | 0 | DIRECT |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
82185,82185
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | DIRECT |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
48034,55931
48034 - Guanido kinase N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0 | DIRECT |
57424,57184
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | DIRECT |
54211,54980
54211 - Ribosomal protein S5 domain 2-like
54980 - EF-G C-terminal domain-like | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0 | DIRECT |
48403,50044
48403 - Ankyrin repeat
50044 - SH3-domain | 0 | DIRECT |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
50044,50156
50044 - SH3-domain
50156 - PDZ domain-like | 0 | DIRECT |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | DIRECT |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52087,101576
52087 - CRAL/TRIO domain
101576 - Supernatant protein factor (SPF), C-terminal domain | 0 | DIRECT |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
54980,54211
54980 - EF-G C-terminal domain-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
81271,55186
81271 - TGS-like
55186 - ThrRS/AlaRS common domain | 0 | DIRECT |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
46942,57783
46942 - Elongation factor TFIIS domain 2
57783 - Zinc beta-ribbon | 0 | DIRECT |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
48371,46785
48371 - ARM repeat
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
69065,54768
69065 - RNase III domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
52540,140990
52540 - P-loop containing nucleoside triphosphate hydrolases
140990 - FtsH protease domain-like | 0 | DIRECT |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
57603,57440
57603 - FnI-like domain
57440 - Kringle-like | 0 | DIRECT |
88713,88688
88713 - Glycoside hydrolase/deacetylase
88688 - Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
47370,47370
47370 - Bromodomain
47370 - Bromodomain | 0 | DIRECT |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | DIRECT |
55486,48371
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | DIRECT |
46565,57938
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
46785,54928
46785 - "Winged helix" DNA-binding domain
54928 - RNA-binding domain, RBD | 0 | DIRECT |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | DIRECT |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | DIRECT |
64268,103657
64268 - PX domain
103657 - BAR/IMD domain-like | 0 | DIRECT |
48350,50729
48350 - GTPase activation domain, GAP
50729 - PH domain-like | 0 | DIRECT |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0 | DIRECT |
82153,82153
82153 - FAS1 domain
82153 - FAS1 domain | 0 | DIRECT |
50729,49562
50729 - PH domain-like
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0 | DIRECT |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | DIRECT |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | DIRECT |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
117281,50965
117281 - Kelch motif
50965 - Galactose oxidase, central domain | 0 | DIRECT |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 0 | DIRECT |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0.004417 | INHERITED FROM: testis || genital system |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.006484 | INHERITED FROM: testis |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.03506 | INHERITED FROM: gamete || egg |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.2413 | INHERITED FROM: embryonic kidney |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.2779 | INHERITED FROM: female genitalia || primary oogonium || ovary || primary spermatogonium |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.9848 | INHERITED FROM: female genitalia || ovary |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0.9867 | INHERITED FROM: pronephric tubule |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 1 | INHERITED FROM: rectal diverticulum |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
46585,46585
46585 - HR1 repeat
46585 - HR1 repeat | 0 | Direct |
103647,49899
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | Direct |
57184,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
88723,47807
88723 - PIN domain-like
47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
57196,100895
57196 - EGF/Laminin
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | Direct |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | Direct |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | Direct |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | Direct |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | Direct |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | Direct |
110324,50249
110324 - Ribosomal L27 protein-like
50249 - Nucleic acid-binding proteins | 0 | Direct |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0 | Direct |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | Direct |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | Direct |
74650,51445
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases | 0 | Direct |
55550,50729
55550 - SH2 domain
50729 - PH domain-like | 0 | Direct |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0 | Direct |
49899,52540
49899 - Concanavalin A-like lectins/glucanases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | Direct |
100895,47473
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand | 0 | Direct |
55945,55945
55945 - TATA-box binding protein-like
55945 - TATA-box binding protein-like | 0 | Direct |
101288,50156
101288 - L27 domain
50156 - PDZ domain-like | 0 | Direct |
51230,47005
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0 | Direct |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | Direct |
142921,47587
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase | 0 | Direct |
90209,90209
90209 - Ran binding protein zinc finger-like
90209 - Ran binding protein zinc finger-like | 0 | Direct |
56112,48371
56112 - Protein kinase-like (PK-like)
48371 - ARM repeat | 0 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0 | Direct |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | Direct |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | Direct |
52425,48173
52425 - Cryptochrome/photolyase, N-terminal domain
48173 - Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0 | Direct |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | Direct |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | Direct |
52058,49265
52058 - L domain-like
49265 - Fibronectin type III | 0 | Direct |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
47005,52777
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | Direct |
81995,81811
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | Direct |
81296,48239
81296 - E set domains
48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
49265,56496
49265 - Fibronectin type III
56496 - Fibrinogen C-terminal domain-like | 0 | Direct |
53300,81995
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0 | Direct |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | Direct |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
47095,47095
47095 - HMG-box
47095 - HMG-box | 0 | Direct |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
82185,82185
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | Direct |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
48034,55931
48034 - Guanido kinase N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0 | Direct |
57424,57184
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | Direct |
54211,54980
54211 - Ribosomal protein S5 domain 2-like
54980 - EF-G C-terminal domain-like | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0 | Direct |
48403,50044
48403 - Ankyrin repeat
50044 - SH3-domain | 0 | Direct |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
50044,50156
50044 - SH3-domain
50156 - PDZ domain-like | 0 | Direct |
51735,56327
51735 - NAD(P)-binding Rossmann-fold domains
56327 - LDH C-terminal domain-like | 0 | Direct |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52087,101576
52087 - CRAL/TRIO domain
101576 - Supernatant protein factor (SPF), C-terminal domain | 0 | Direct |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
54980,54211
54980 - EF-G C-terminal domain-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
81271,55186
81271 - TGS-like
55186 - ThrRS/AlaRS common domain | 0 | Direct |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
46942,57783
46942 - Elongation factor TFIIS domain 2
57783 - Zinc beta-ribbon | 0 | Direct |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
48371,46785
48371 - ARM repeat
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
69065,54768
69065 - RNase III domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
52540,140990
52540 - P-loop containing nucleoside triphosphate hydrolases
140990 - FtsH protease domain-like | 0 | Direct |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | Direct |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
57603,57440
57603 - FnI-like domain
57440 - Kringle-like | 0 | Direct |
88713,88688
88713 - Glycoside hydrolase/deacetylase
88688 - Families 57/38 glycoside transferase middle domain | 0 | Direct |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
47370,47370
47370 - Bromodomain
47370 - Bromodomain | 0 | Direct |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | Direct |
55486,48371
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | Direct |
46565,57938
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
46785,54928
46785 - "Winged helix" DNA-binding domain
54928 - RNA-binding domain, RBD | 0 | Direct |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | Direct |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | Direct |
64268,103657
64268 - PX domain
103657 - BAR/IMD domain-like | 0 | Direct |
48350,50729
48350 - GTPase activation domain, GAP
50729 - PH domain-like | 0 | Direct |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0 | Direct |
82153,82153
82153 - FAS1 domain
82153 - FAS1 domain | 0 | Direct |
50729,49562
50729 - PH domain-like
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0 | Direct |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | Direct |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | Direct |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
117281,50965
117281 - Kelch motif
50965 - Galactose oxidase, central domain | 0 | Direct |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 0 | Direct |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | Direct |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0.004417 | Inherited |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.006484 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.03506 | Inherited |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.2413 | Inherited |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.2779 | Inherited |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.9848 | Inherited |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0.9867 | Inherited |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 1 | Inherited |
(show details)
Supra-domains annotated to this XA term (SPXA level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
49899,57196,49899
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
52058,49265,49265
52058 - L domain-like
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
63737,55486,48371
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | DIRECT |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | DIRECT |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | DIRECT |
53300,81995,81811
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | DIRECT |
103657,50729,48350
103657 - BAR/IMD domain-like
50729 - PH domain-like
48350 - GTPase activation domain, GAP | 0 | DIRECT |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
49899,57196,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
57850,49599,49599
57850 - RING/U-box
49599 - TRAF domain-like
49599 - TRAF domain-like | 0 | DIRECT |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
50447,54980,54211
50447 - Translation proteins
54980 - EF-G C-terminal domain-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
54768,54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
52743,49785,57184
52743 - Subtilisin-like
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
46565,57938,49493
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
103647,103647,49899
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54980,54211,54980
54980 - EF-G C-terminal domain-like
54211 - Ribosomal protein S5 domain 2-like
54980 - EF-G C-terminal domain-like | 0 | DIRECT |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
81995,81811,82754
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
142921,47587,56399
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | DIRECT |
49785,49785,49899
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
47220,47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
74650,51445,51011
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | DIRECT |
46689,46689,46689
46689 - Homeodomain-like
46689 - Homeodomain-like
46689 - Homeodomain-like | 0 | DIRECT |
50729,49562,48350
50729 - PH domain-like
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48350 - GTPase activation domain, GAP | 0 | DIRECT |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
90229,90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | DIRECT |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | DIRECT |
57184,52058,49265
57184 - Growth factor receptor domain
52058 - L domain-like
49265 - Fibronectin type III | 0 | DIRECT |
46585,46585,46585
46585 - HR1 repeat
46585 - HR1 repeat
46585 - HR1 repeat | 0 | DIRECT |
46938,52087,101576
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain
101576 - Supernatant protein factor (SPF), C-terminal domain | 0 | DIRECT |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
51230,47005,52777
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
103647,103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | DIRECT |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | DIRECT |
57196,49899,57196
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0 | DIRECT |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
101288,50156,50044
101288 - L27 domain
50156 - PDZ domain-like
50044 - SH3-domain | 0 | DIRECT |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0.2012 | INHERITED FROM: urinary system || kidney |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.4992 | INHERITED FROM: female genitalia || ovary |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.8326 | INHERITED FROM: embryonic kidney |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.8923 | INHERITED FROM: embryonic kidney |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | Direct |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
49899,57196,49899
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
52058,49265,49265
52058 - L domain-like
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
63737,55486,48371
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | Direct |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | Direct |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | Direct |
53300,81995,81811
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | Direct |
103657,50729,48350
103657 - BAR/IMD domain-like
50729 - PH domain-like
48350 - GTPase activation domain, GAP | 0 | Direct |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
49899,57196,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
57850,49599,49599
57850 - RING/U-box
49599 - TRAF domain-like
49599 - TRAF domain-like | 0 | Direct |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
50447,54980,54211
50447 - Translation proteins
54980 - EF-G C-terminal domain-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
54768,54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
52743,49785,57184
52743 - Subtilisin-like
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | Direct |
46565,57938,49493
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
103647,103647,49899
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54980,54211,54980
54980 - EF-G C-terminal domain-like
54211 - Ribosomal protein S5 domain 2-like
54980 - EF-G C-terminal domain-like | 0 | Direct |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
81995,81811,82754
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
142921,47587,56399
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | Direct |
49785,49785,49899
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
47220,47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
74650,51445,51011
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | Direct |
46689,46689,46689
46689 - Homeodomain-like
46689 - Homeodomain-like
46689 - Homeodomain-like | 0 | Direct |
50729,49562,48350
50729 - PH domain-like
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48350 - GTPase activation domain, GAP | 0 | Direct |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
90229,90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | Direct |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
48452,48452,48452
48452 - TPR-like
48452 - TPR-like
48452 - TPR-like | 0 | Direct |
57184,52058,49265
57184 - Growth factor receptor domain
52058 - L domain-like
49265 - Fibronectin type III | 0 | Direct |
46585,46585,46585
46585 - HR1 repeat
46585 - HR1 repeat
46585 - HR1 repeat | 0 | Direct |
46938,52087,101576
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain
101576 - Supernatant protein factor (SPF), C-terminal domain | 0 | Direct |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
51230,47005,52777
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | Direct |
103647,103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | Direct |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | Direct |
57196,49899,57196
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0 | Direct |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | Direct |
101288,50156,50044
101288 - L27 domain
50156 - PDZ domain-like
50044 - SH3-domain | 0 | Direct |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0.2012 | Inherited |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.4992 | Inherited |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.8326 | Inherited |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.8923 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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