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Xenopus ANatomical entity (XAN): nervous system
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: XA Hierarchy (Xenopus anatomy and development from Xenbase frog anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this XA term (SDXA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| ClpS-like | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| Oligoxyloglucan reducing end-specific cellobiohydrolase | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| ThrRS/AlaRS common domain | 0 | DIRECT |
| Sialidases | 0 | DIRECT |
| USP8 N-terminal domain-like | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| Dimeric alpha+beta barrel | 0 | DIRECT |
| Stathmin | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| Pentein | 0 | DIRECT |
| Ligand-binding domain in the NO signalling and Golgi transport | 0 | DIRECT |
| Aminomethyltransferase beta-barrel domain | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
| RNase III domain-like | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| post-AAA+ oligomerization domain-like | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| NAP-like | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| GINS helical bundle-like | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Endosomal sorting complex assembly domain | 0 | DIRECT |
| Mib/herc2 domain-like | 0 | DIRECT |
| ARID-like | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| PriA/YqbF domain | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| Glycoside hydrolase/deacetylase | 0 | DIRECT |
| Cysteine alpha-hairpin motif | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | DIRECT |
| ACP-like | 0 | DIRECT |
| Mss4-like | 0 | DIRECT |
| I/LWEQ domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| MAST3 pre-PK domain-like | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| Glutamine synthetase/guanido kinase | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| TGS-like | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| AraD/HMP-PK domain-like | 0 | DIRECT |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
| Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| Hedgehog/DD-peptidase | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Hook domain | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| Enolase C-terminal domain-like | 0 | DIRECT |
| DLC | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| TNF receptor-like | 0 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| LuxS/MPP-like metallohydrolase | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Cytokine | 0 | DIRECT |
| Acyl-CoA binding protein | 0 | DIRECT |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
| eIF1-like | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Homeodomain-like | 0.0005416 | DIRECT |
| Cadherin-like | 0.0007148 | DIRECT |
| Ubiquitin-like | 0.00166 | INHERITED FROM: brain || central nervous system |
| RNA-binding domain, RBD | 0.001915 | INHERITED FROM: spinal cord || eye || hindbrain || sensory system || central nervous system |
| Second domain of FERM | 0.00268 | INHERITED FROM: gustatory system || peripheral nervous system |
| HMG-box | 0.002936 | INHERITED FROM: midbrain-hindbrain boundary || spinal cord || forebrain || retinal layer || otic vesicle || hindbrain || sensory system |
| ARM repeat | 0.003362 | INHERITED FROM: central nervous system |
| HLH, helix-loop-helix DNA-binding domain | 0.004327 | INHERITED FROM: cranial ganglion || neural progenitor cell || neuron || spinal cord || ventricular zone || lateral line system || retinal ganglion cell layer || forebrain || eye || retinal inner nuclear layer || ganglion || otic vesicle || hindbrain || sensory system || enteric nervous system || retinal outer nuclear layer || neural tube || midbrain || retinal stem cell region || Rohon-Beard neuron || presumptive midbrain-hindbrain boundary || lateral line || olfactory system || eye primordium || peripheral nervous system || optic vesicle || chordoneural hinge |
| Tubulin C-terminal domain-like | 0.005563 | INHERITED FROM: intersomitic neuron || glossopharyngeal nerve || neuron || vagus nerve || facial nerve || spinal neuron || trigeminal nerve |
| UBC-like | 0.006728 | INHERITED FROM: central nervous system |
| Frizzled cysteine-rich domain | 0.0119 | INHERITED FROM: midbrain-hindbrain boundary || forebrain || eye || otic vesicle || hindbrain || sensory system || neural tube || midbrain || vestibuloauditory system || optic vesicle |
| Tubulin nucleotide-binding domain-like | 0.0306 | INHERITED FROM: intersomitic neuron || glossopharyngeal nerve || neuron || vagus nerve || facial nerve || spinal neuron || trigeminal nerve |
| Transducin (alpha subunit), insertion domain | 0.0713 | INHERITED FROM: olfactory sensory neuron || olfactory epithelium || sensory system |
| PH domain-like | 0.07515 | INHERITED FROM: brain |
| Ras GEF | 0.1088 | INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer |
| Growth factor receptor domain | 0.1183 | INHERITED FROM: neuromere || spinal cord || otic vesicle |
| Spectrin repeat | 0.1237 | INHERITED FROM: auditory apparatus || auditory ossicle || inner ear || auditory hair cell |
| lambda repressor-like DNA-binding domains | 0.1331 | INHERITED FROM: neuron || spinal cord || neural tube || presumptive midbrain-hindbrain boundary |
| PYP-like sensor domain (PAS domain) | 0.1467 | INHERITED FROM: visual system || spinal cord || eye |
| Voltage-gated potassium channels | 0.1711 | INHERITED FROM: axon || retinal neural layer || neuron || spinal cord || cephalic nerve || retinal ganglion cell layer || nerve || optic nerve || retinal inner plexiform layer || optic disc |
| Orange domain-like | 0.1807 | INHERITED FROM: visual system || floor plate || spinal cord || eye || sensory system || neural tube || midbrain || trigeminal ganglion || chordoneural hinge |
| "Winged helix" DNA-binding domain | 0.2507 | INHERITED FROM: spinal cord || eye || otic vesicle || sensory system || neural tube |
| Sema domain | 0.4204 | INHERITED FROM: sensory system || otic placode || presumptive midbrain-hindbrain boundary |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.4405 | INHERITED FROM: optic tectum || medial septum || basal forebrain || thalamus || neuromere || spinal cord || septum || ventral pallium || amygdala || forebrain || neural nucleus || ventrolateral thalamic nucleus || prosomere || ventral septum || basal ganglion || hypothalamus || zona limitans intrathalamica || hindbrain || midbrain || lateral septum || anterior hypothalamus || preoptic area || subpallium || striatum || diencephalon || pretectum |
| Plexin repeat | 0.5369 | INHERITED FROM: sensory system || otic placode || presumptive midbrain-hindbrain boundary |
| p53-like transcription factors | 0.6581 | INHERITED FROM: neuron || facial nerve || sensory system |
| Fibronectin type III | 0.6808 | INHERITED FROM: retinal neural layer || retinal ganglion cell layer || retinal inner nuclear layer |
| Kazal-type serine protease inhibitors | 0.71 | INHERITED FROM: floor plate || spinal cord |
| DNA-binding domain | 0.7407 | INHERITED FROM: eye primordium |
| POZ domain | 0.8181 | INHERITED FROM: axon || optic disc |
| Intermediate filament protein, coiled coil region | 0.9089 | INHERITED FROM: gustatory system || neuron || ventricular zone || cephalic nerve || retinal ganglion cell layer || neural nucleus || retinal inner nuclear layer || retinal ganglion cell || ganglion || nerve || spinal ganglion || optic nerve || spinal neuron || midbrain tegmentum || retinal inner plexiform layer || medulla oblongata || peripheral nervous system |
| gamma-Crystallin-like | 1 | INHERITED FROM: lens |
| Cystine-knot cytokines | 1 | INHERITED FROM: neural tube |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: medial pallium || basal forebrain || septum || granule cell layer of the olfactory bulb || amygdala || neural nucleus || basal ganglion || hypothalamus || anterior hypothalamus || preoptic area || pallium || striatum || diencephalon |
| EGF/Laminin | 1 | INHERITED FROM: floor plate || spinal cord |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| ClpS-like | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| Enolase N-terminal domain-like | 0 | Direct |
| PAH2 domain | 0 | Direct |
| Oligoxyloglucan reducing end-specific cellobiohydrolase | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| ThrRS/AlaRS common domain | 0 | Direct |
| Sialidases | 0 | Direct |
| USP8 N-terminal domain-like | 0 | Direct |
| Synuclein | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| GroEL-intermediate domain like | 0 | Direct |
| Dimeric alpha+beta barrel | 0 | Direct |
| Stathmin | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Tim10-like | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| Pentein | 0 | Direct |
| Ligand-binding domain in the NO signalling and Golgi transport | 0 | Direct |
| Aminomethyltransferase beta-barrel domain | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| Families 57/38 glycoside transferase middle domain | 0 | Direct |
| RNase III domain-like | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| BEACH domain | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| post-AAA+ oligomerization domain-like | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| NAP-like | 0 | Direct |
| LeuD/IlvD-like | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| GINS helical bundle-like | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Endosomal sorting complex assembly domain | 0 | Direct |
| Mib/herc2 domain-like | 0 | Direct |
| ARID-like | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| PriA/YqbF domain | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| Glycoside hydrolase/deacetylase | 0 | Direct |
| Cysteine alpha-hairpin motif | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | Direct |
| ACP-like | 0 | Direct |
| Mss4-like | 0 | Direct |
| I/LWEQ domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| MAST3 pre-PK domain-like | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| Glutamine synthetase/guanido kinase | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| TGS-like | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| CCHHC domain | 0 | Direct |
| AraD/HMP-PK domain-like | 0 | Direct |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
| Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| GYF domain | 0 | Direct |
| Hedgehog/DD-peptidase | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Hook domain | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| Enolase C-terminal domain-like | 0 | Direct |
| DLC | 0 | Direct |
| Nop domain | 0 | Direct |
| TNF receptor-like | 0 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
| Notch domain | 0 | Direct |
| LuxS/MPP-like metallohydrolase | 0 | Direct |
| SRF-like | 0 | Direct |
| Cytokine | 0 | Direct |
| Acyl-CoA binding protein | 0 | Direct |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
| eIF1-like | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Homeodomain-like | 0.0005416 | Direct |
| Cadherin-like | 0.0007148 | Direct |
| Ubiquitin-like | 0.00166 | Inherited |
| RNA-binding domain, RBD | 0.001915 | Inherited |
| Second domain of FERM | 0.00268 | Inherited |
| HMG-box | 0.002936 | Inherited |
| ARM repeat | 0.003362 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.004327 | Inherited |
| Tubulin C-terminal domain-like | 0.005563 | Inherited |
| UBC-like | 0.006728 | Inherited |
| Frizzled cysteine-rich domain | 0.0119 | Inherited |
| Tubulin nucleotide-binding domain-like | 0.0306 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.0713 | Inherited |
| PH domain-like | 0.07515 | Inherited |
| Ras GEF | 0.1088 | Inherited |
| Growth factor receptor domain | 0.1183 | Inherited |
| Spectrin repeat | 0.1237 | Inherited |
| lambda repressor-like DNA-binding domains | 0.1331 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.1467 | Inherited |
| Voltage-gated potassium channels | 0.1711 | Inherited |
| Orange domain-like | 0.1807 | Inherited |
| "Winged helix" DNA-binding domain | 0.2507 | Inherited |
| Sema domain | 0.4204 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.4405 | Inherited |
| Plexin repeat | 0.5369 | Inherited |
| p53-like transcription factors | 0.6581 | Inherited |
| Fibronectin type III | 0.6808 | Inherited |
| Kazal-type serine protease inhibitors | 0.71 | Inherited |
| DNA-binding domain | 0.7407 | Inherited |
| POZ domain | 0.8181 | Inherited |
| Intermediate filament protein, coiled coil region | 0.9089 | Inherited |
| gamma-Crystallin-like | 1 | Inherited |
| Cystine-knot cytokines | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
| EGF/Laminin | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this XA term (SDXA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Stathmin | 0 | DIRECT |
| Hedgehog (development protein), N-terminal signaling domain | 0 | DIRECT |
| Ferritin | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| Trunk domain of Sec23/24 | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | DIRECT |
| PreBEACH PH-like domain | 0 | DIRECT |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | DIRECT |
| ARID domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | DIRECT |
| LeuD-like | 0 | DIRECT |
| Pumilio repeat | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| APC10-like | 0 | DIRECT |
| Hook domain | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| eIF1-like | 0 | DIRECT |
| UDP-glucose pyrophosphorylase | 0 | DIRECT |
| I/LWEQ domain | 0 | DIRECT |
| Mib/herc2 domain | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | DIRECT |
| Adenain-like | 0 | DIRECT |
| Cofactor-dependent phosphoglycerate mutase | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| TNF receptor-like | 0 | DIRECT |
| Glyoxalase II (hydroxyacylglutathione hydrolase) | 0 | DIRECT |
| Linker histone H1/H5 | 0 | DIRECT |
| alpha-mannosidase | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| HD domain | 0 | DIRECT |
| Cytochrome b5 | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| Protein-L-isoaspartyl O-methyltransferase | 0 | DIRECT |
| GS domain | 0 | DIRECT |
| RuBisCo LSMT catalytic domain | 0 | DIRECT |
| HCDH C-domain-like | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| HAT/Suf repeat | 0 | DIRECT |
| DNA gyrase/MutL, second domain | 0 | DIRECT |
| CUE domain | 0 | DIRECT |
| DNA polymerase III clamp loader subunits, C-terminal domain | 0 | DIRECT |
| gamma-adaptin C-terminal appendage domain-like | 0 | DIRECT |
| Guanido kinase catalytic domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Gonadodropin/Follitropin | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| TRASH domain | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| NIPSNAP | 0 | DIRECT |
| DNA ligase | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Glycosyl transferases group 1 | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| MPP-like | 0 | DIRECT |
| Autophagin-like | 0 | DIRECT |
| Alpha-adaptin ear subdomain-like | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| IF2B-like | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Acyl-CoA binding protein | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| SIAH, seven in absentia homolog | 0 | DIRECT |
| Sedlin (SEDL) | 0 | DIRECT |
| Aminomethyltransferase beta-barrel domain | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| Phoshatidylinositol transfer protein, PITP | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| MSP-like | 0 | DIRECT |
| DLC | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| Variant RING domain | 0 | DIRECT |
| alpha-mannosidase, domain 2 | 0 | DIRECT |
| Alanine racemase-like, N-terminal domain | 0 | DIRECT |
| Other IPT/TIG domains | 0 | DIRECT |
| RPR domain (SMART 00582 ) | 0 | DIRECT |
| Ephrin receptor ligand binding domain | 0 | DIRECT |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| USP8 N-terminal domain-like | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Arrestin/Vps26-like | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| ZZ domain | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| DIX domain | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| MAST3 pre-PK domain-like | 0 | DIRECT |
| Noggin | 0 | DIRECT |
| Eukaryotic ODC-like | 0 | DIRECT |
| Tim10/DDP | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| NAP-like | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| Cyclin A/CDK2-associated p19, Skp2 | 0 | DIRECT |
| 4HBT-like | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| alpha-mannosidase, C-terminal domain | 0 | DIRECT |
| Carboxylesterase/thioesterase 1 | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| alpha-catenin/vinculin | 0 | DIRECT |
| A20-like zinc finger | 0 | DIRECT |
| Neutral endopeptidase (neprilysin) | 0 | DIRECT |
| Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| P4 origin-binding domain-like | 0 | DIRECT |
| 1,3-glucuronyltransferase | 0 | DIRECT |
| Threonyl-tRNA synthetase (ThrRS), second 'additional' domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| Chromo barrel domain | 0 | DIRECT |
| TRAPP components | 0 | DIRECT |
| Phosphoribosylpyrophosphate synthetase-like | 0 | DIRECT |
| Ran-binding domain | 0 | DIRECT |
| S-adenosylhomocystein hydrolase | 0 | DIRECT |
| DJ-1/PfpI | 0 | DIRECT |
| Transferrin | 0 | DIRECT |
| RhoGDI-like | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| DNA gyrase/MutL, N-terminal domain | 0 | DIRECT |
| Fibroblast growth factors (FGF) | 0 | DIRECT |
| SH3BGR (SH3-binding, glutamic acid-rich protein-like) | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| Cytidylyltransferase | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| a tRNA synthase domain | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| AraD-like aldolase/epimerase | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
| GDI-like N domain | 0 | DIRECT |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | DIRECT |
| B56-like | 0 | DIRECT |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
| Canonical RBD | 0.0001625 | DIRECT |
| UBC-related | 0.0005434 | DIRECT |
| Cadherin | 0.0009595 | DIRECT |
| Third domain of FERM | 0.002184 | INHERITED FROM: central nervous system |
| Homeodomain | 0.002834 | INHERITED FROM: medial septum || olfactory bulb || bed nucleus of the stria terminalis || midbrain-hindbrain boundary || basal forebrain || neurenteric canal || profundus ganglion || lateral pallium || thalamus || neuromere || roof plate || dorsal thalamus || neuron || spinal cord || ventricular zone || cephalic nerve || septum || retinal ganglion cell layer || ventral pallium || amygdala || forebrain || neural nucleus || eye || prosomere || retinal inner nuclear layer || ventral septum || ganglion || lateral ganglionic eminence || nerve || prethalamus || basal ganglion || hypothalamus || zona limitans intrathalamica || otic vesicle || medial ganglionic eminence || hindbrain || rhombomere || sensory system || telencephalon || otic placode || enteric nervous system || neural tube || midbrain || lateral septum || anterior neural tube || anterior hypothalamus || preoptic area || presumptive midbrain-hindbrain boundary || subpallium || pallidum || infundibulum || pallium || posterior neural tube || pineal gland || striatum || eye primordium || posterior wall of neurenteric canal || posterior hypothalamus || peripheral nervous system || optic stalk || diencephalon || pretectum || chordoneural hinge |
| HMG-box | 0.002975 | INHERITED FROM: midbrain-hindbrain boundary || spinal cord || forebrain || retinal layer || otic vesicle || hindbrain || sensory system |
| Second domain of FERM | 0.004288 | INHERITED FROM: trigeminal nerve |
| HLH, helix-loop-helix DNA-binding domain | 0.004988 | INHERITED FROM: cranial ganglion || neural progenitor cell || neuron || spinal cord || ventricular zone || lateral line system || retinal ganglion cell layer || forebrain || eye || retinal inner nuclear layer || ganglion || otic vesicle || hindbrain || sensory system || enteric nervous system || retinal outer nuclear layer || neural tube || midbrain || retinal stem cell region || Rohon-Beard neuron || presumptive midbrain-hindbrain boundary || lateral line || olfactory system || eye primordium || peripheral nervous system || optic vesicle || chordoneural hinge |
| Tubulin, GTPase domain | 0.005035 | INHERITED FROM: intersomitic neuron || glossopharyngeal nerve || neuron || vagus nerve || facial nerve || spinal neuron || trigeminal nerve |
| Tubulin, C-terminal domain | 0.005035 | INHERITED FROM: intersomitic neuron || glossopharyngeal nerve || neuron || vagus nerve || facial nerve || spinal neuron || trigeminal nerve |
| Frizzled cysteine-rich domain | 0.01101 | INHERITED FROM: midbrain-hindbrain boundary || forebrain || eye || otic vesicle || hindbrain || sensory system || neural tube || midbrain || vestibuloauditory system || optic vesicle |
| Laminin G-like module | 0.01202 | INHERITED FROM: spinal cord |
| Histone lysine methyltransferases | 0.03092 | INHERITED FROM: hindbrain |
| Growth factor receptor domain | 0.0429 | INHERITED FROM: spinal cord || sensory system |
| G proteins | 0.04779 | INHERITED FROM: olfactory sensory neuron || olfactory epithelium |
| Transducin (alpha subunit), insertion domain | 0.0655 | INHERITED FROM: olfactory sensory neuron || olfactory epithelium || sensory system |
| Voltage-gated potassium channels | 0.09615 | INHERITED FROM: axon || neuron || optic nerve || retinal inner plexiform layer || optic disc |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0.1062 | INHERITED FROM: neuron || neuron projection |
| LIM domain | 0.1113 | INHERITED FROM: bed nucleus of the stria terminalis || basal forebrain || thalamus || neuromere || central nucleus of the thalamus || septum || amygdala || neural nucleus || ventrolateral thalamic nucleus || prosomere || ventral septum || medial amygdala || anterior thalamic nucleus || prosomere 4 || pretectum |
| ets domain | 0.1215 | INHERITED FROM: spinal cord || eye || otic vesicle || sensory system |
| POU-specific domain | 0.1596 | INHERITED FROM: neuron || spinal cord || retinal ganglion cell layer || neural tube || presumptive midbrain-hindbrain boundary |
| Hairy Orange domain | 0.169 | INHERITED FROM: visual system || floor plate || spinal cord || eye || sensory system || neural tube || midbrain || trigeminal ganglion || chordoneural hinge |
| Spectrin repeat | 0.1964 | INHERITED FROM: auditory apparatus || auditory ossicle || inner ear || auditory hair cell |
| Glutathione peroxidase-like | 0.2006 | INHERITED FROM: eye primordium |
| Paired domain | 0.2136 | INHERITED FROM: midbrain-hindbrain boundary || neuromere || neuron || spinal cord || forebrain || neural tube || midbrain || anterior neural tube || posterior neural tube |
| Forkhead DNA-binding domain | 0.2556 | INHERITED FROM: floor plate || spinal cord || eye || sensory system || neural tube || chordoneural hinge |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.291 | INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.3009 | INHERITED FROM: otic vesicle |
| T-box | 0.3241 | INHERITED FROM: sensory system |
| L domain | 0.3291 | INHERITED FROM: spinal cord || otic vesicle || vestibuloauditory system |
| Arginine methyltransferase | 0.3291 | INHERITED FROM: optic vesicle |
| Sema domain | 0.3462 | INHERITED FROM: midbrain-hindbrain boundary || sensory system || otic placode || presumptive midbrain-hindbrain boundary |
| VWC domain | 0.3537 | INHERITED FROM: neural tube |
| Tetramerization domain of potassium channels | 0.3747 | INHERITED FROM: axon || neuron || neuron projection || retinal ganglion cell layer || retinal outer plexiform layer || optic nerve || retinal inner plexiform layer || optic disc |
| I set domains | 0.4875 | INHERITED FROM: spinal cord || retinal ganglion cell layer || retinal inner nuclear layer || optic vesicle |
| Ovomucoid domain III-like | 0.5184 | INHERITED FROM: floor plate || spinal cord |
| Tandem AAA-ATPase domain | 0.5317 | INHERITED FROM: forebrain || otic vesicle || hindbrain || midbrain || vestibuloauditory system |
| Plexin repeat | 0.5352 | INHERITED FROM: sensory system || otic placode || presumptive midbrain-hindbrain boundary |
| Classic zinc finger, C2H2 | 0.5989 | INHERITED FROM: spinal cord || hindbrain || midbrain |
| Fibronectin type III | 0.6401 | INHERITED FROM: retinal neural layer || retinal ganglion cell layer |
| Link domain | 0.7623 | INHERITED FROM: vestibuloauditory system |
| Intermediate filament protein, coiled coil region | 0.9025 | INHERITED FROM: gustatory system || neuron || ventricular zone || cephalic nerve || retinal ganglion cell layer || neural nucleus || retinal inner nuclear layer || retinal ganglion cell || ganglion || nerve || vestibulocochlear nerve || spinal ganglion || optic nerve || spinal neuron || midbrain tegmentum || retinal inner plexiform layer || medulla oblongata || peripheral nervous system || nucleus reticularis inferior |
| EGF-type module | 1 | INHERITED FROM: spinal cord |
| Rhodopsin-like | 1 | INHERITED FROM: medial pallium || basal forebrain || septum || granule cell layer of the olfactory bulb || amygdala || neural nucleus || basal ganglion || hypothalamus || anterior hypothalamus || preoptic area || pallium || striatum || eye photoreceptor cell || diencephalon |
| Crystallins/Ca-binding development proteins | 1 | INHERITED FROM: lens |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Stathmin | 0 | Direct |
| Hedgehog (development protein), N-terminal signaling domain | 0 | Direct |
| Ferritin | 0 | Direct |
| Enolase N-terminal domain-like | 0 | Direct |
| Trunk domain of Sec23/24 | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | Direct |
| PreBEACH PH-like domain | 0 | Direct |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | Direct |
| ARID domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | Direct |
| LeuD-like | 0 | Direct |
| Pumilio repeat | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| APC10-like | 0 | Direct |
| Hook domain | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| eIF1-like | 0 | Direct |
| UDP-glucose pyrophosphorylase | 0 | Direct |
| I/LWEQ domain | 0 | Direct |
| Mib/herc2 domain | 0 | Direct |
| NTF2-like | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | Direct |
| Adenain-like | 0 | Direct |
| Cofactor-dependent phosphoglycerate mutase | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| TNF receptor-like | 0 | Direct |
| Glyoxalase II (hydroxyacylglutathione hydrolase) | 0 | Direct |
| Linker histone H1/H5 | 0 | Direct |
| alpha-mannosidase | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| HD domain | 0 | Direct |
| Cytochrome b5 | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| Protein-L-isoaspartyl O-methyltransferase | 0 | Direct |
| GS domain | 0 | Direct |
| RuBisCo LSMT catalytic domain | 0 | Direct |
| HCDH C-domain-like | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| HAT/Suf repeat | 0 | Direct |
| DNA gyrase/MutL, second domain | 0 | Direct |
| CUE domain | 0 | Direct |
| DNA polymerase III clamp loader subunits, C-terminal domain | 0 | Direct |
| gamma-adaptin C-terminal appendage domain-like | 0 | Direct |
| Guanido kinase catalytic domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Gonadodropin/Follitropin | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| TRASH domain | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| NIPSNAP | 0 | Direct |
| DNA ligase | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Glycosyl transferases group 1 | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| MPP-like | 0 | Direct |
| Autophagin-like | 0 | Direct |
| Alpha-adaptin ear subdomain-like | 0 | Direct |
| CCHHC domain | 0 | Direct |
| IF2B-like | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| SRF-like | 0 | Direct |
| Notch domain | 0 | Direct |
| Acyl-CoA binding protein | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| SIAH, seven in absentia homolog | 0 | Direct |
| Sedlin (SEDL) | 0 | Direct |
| Aminomethyltransferase beta-barrel domain | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| Phoshatidylinositol transfer protein, PITP | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| MSP-like | 0 | Direct |
| DLC | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| Variant RING domain | 0 | Direct |
| alpha-mannosidase, domain 2 | 0 | Direct |
| Alanine racemase-like, N-terminal domain | 0 | Direct |
| Other IPT/TIG domains | 0 | Direct |
| RPR domain (SMART 00582 ) | 0 | Direct |
| Ephrin receptor ligand binding domain | 0 | Direct |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| USP8 N-terminal domain-like | 0 | Direct |
| SMAD domain | 0 | Direct |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | Direct |
| Arrestin/Vps26-like | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| ZZ domain | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| DIX domain | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| MAST3 pre-PK domain-like | 0 | Direct |
| Noggin | 0 | Direct |
| Eukaryotic ODC-like | 0 | Direct |
| Tim10/DDP | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| NAP-like | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| Cyclin A/CDK2-associated p19, Skp2 | 0 | Direct |
| 4HBT-like | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| alpha-mannosidase, C-terminal domain | 0 | Direct |
| Carboxylesterase/thioesterase 1 | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| PAH2 domain | 0 | Direct |
| alpha-catenin/vinculin | 0 | Direct |
| A20-like zinc finger | 0 | Direct |
| Neutral endopeptidase (neprilysin) | 0 | Direct |
| Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| P4 origin-binding domain-like | 0 | Direct |
| 1,3-glucuronyltransferase | 0 | Direct |
| Threonyl-tRNA synthetase (ThrRS), second 'additional' domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| BEACH domain | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| Chromo barrel domain | 0 | Direct |
| TRAPP components | 0 | Direct |
| Phosphoribosylpyrophosphate synthetase-like | 0 | Direct |
| Ran-binding domain | 0 | Direct |
| S-adenosylhomocystein hydrolase | 0 | Direct |
| DJ-1/PfpI | 0 | Direct |
| Transferrin | 0 | Direct |
| RhoGDI-like | 0 | Direct |
| Nop domain | 0 | Direct |
| DNA gyrase/MutL, N-terminal domain | 0 | Direct |
| Fibroblast growth factors (FGF) | 0 | Direct |
| SH3BGR (SH3-binding, glutamic acid-rich protein-like) | 0 | Direct |
| Synuclein | 0 | Direct |
| Cytidylyltransferase | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| a tRNA synthase domain | 0 | Direct |
| Cullin repeat | 0 | Direct |
| Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| AraD-like aldolase/epimerase | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
| GDI-like N domain | 0 | Direct |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | Direct |
| B56-like | 0 | Direct |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
| Canonical RBD | 0.0001625 | Direct |
| UBC-related | 0.0005434 | Direct |
| Cadherin | 0.0009595 | Direct |
| Third domain of FERM | 0.002184 | Inherited |
| Homeodomain | 0.002834 | Inherited |
| HMG-box | 0.002975 | Inherited |
| Second domain of FERM | 0.004288 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.004988 | Inherited |
| Tubulin, GTPase domain | 0.005035 | Inherited |
| Tubulin, C-terminal domain | 0.005035 | Inherited |
| Frizzled cysteine-rich domain | 0.01101 | Inherited |
| Laminin G-like module | 0.01202 | Inherited |
| Histone lysine methyltransferases | 0.03092 | Inherited |
| Growth factor receptor domain | 0.0429 | Inherited |
| G proteins | 0.04779 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.0655 | Inherited |
| Voltage-gated potassium channels | 0.09615 | Inherited |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0.1062 | Inherited |
| LIM domain | 0.1113 | Inherited |
| ets domain | 0.1215 | Inherited |
| POU-specific domain | 0.1596 | Inherited |
| Hairy Orange domain | 0.169 | Inherited |
| Spectrin repeat | 0.1964 | Inherited |
| Glutathione peroxidase-like | 0.2006 | Inherited |
| Paired domain | 0.2136 | Inherited |
| Forkhead DNA-binding domain | 0.2556 | Inherited |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.291 | Inherited |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.3009 | Inherited |
| T-box | 0.3241 | Inherited |
| L domain | 0.3291 | Inherited |
| Arginine methyltransferase | 0.3291 | Inherited |
| Sema domain | 0.3462 | Inherited |
| VWC domain | 0.3537 | Inherited |
| Tetramerization domain of potassium channels | 0.3747 | Inherited |
| I set domains | 0.4875 | Inherited |
| Ovomucoid domain III-like | 0.5184 | Inherited |
| Tandem AAA-ATPase domain | 0.5317 | Inherited |
| Plexin repeat | 0.5352 | Inherited |
| Classic zinc finger, C2H2 | 0.5989 | Inherited |
| Fibronectin type III | 0.6401 | Inherited |
| Link domain | 0.7623 | Inherited |
| Intermediate filament protein, coiled coil region | 0.9025 | Inherited |
| EGF-type module | 1 | Inherited |
| Rhodopsin-like | 1 | Inherited |
| Crystallins/Ca-binding development proteins | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this XA term (SPXA level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Endosomal sorting complex assembly domain | 0 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| Acyl-CoA binding protein | 0 | DIRECT |
| Hedgehog/DD-peptidase | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Dimeric alpha+beta barrel | 0 | DIRECT |
| LuxS/MPP-like metallohydrolase | 0 | DIRECT |
| Hook domain | 0 | DIRECT |
| TNF receptor-like | 0 | DIRECT |
| Oligoxyloglucan reducing end-specific cellobiohydrolase | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| RNase III domain-like | 0 | DIRECT |
| Sialidases | 0 | DIRECT |
| Mss4-like | 0 | DIRECT |
| Enolase C-terminal domain-like | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| MAST3 pre-PK domain-like | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| Aminomethyltransferase beta-barrel domain | 0 | DIRECT |
| Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
| GINS helical bundle-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| eIF1-like | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| USP8 N-terminal domain-like | 0 | DIRECT |
| DLC | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| I/LWEQ domain | 0 | DIRECT |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | DIRECT |
| post-AAA+ oligomerization domain-like | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| TGS-like | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
| ClpS-like | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Glycoside hydrolase/deacetylase | 0 | DIRECT |
| Stathmin | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| ThrRS/AlaRS common domain | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| NAP-like | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| Glutamine synthetase/guanido kinase | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| Cysteine alpha-hairpin motif | 0 | DIRECT |
| Ligand-binding domain in the NO signalling and Golgi transport | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Mib/herc2 domain-like | 0 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
| Pentein | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| AraD/HMP-PK domain-like | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| ACP-like | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| ARID-like | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| PriA/YqbF domain | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Cytokine | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
| Homeodomain-like | 0.0004075 | DIRECT |
| Cadherin-like | 0.0005399 | DIRECT |
| Ubiquitin-like | 0.001267 | INHERITED FROM: brain || central nervous system |
| RNA-binding domain, RBD | 0.001466 | INHERITED FROM: eye || central nervous system || forebrain || peripheral retina || hindbrain || sensory system || spinal cord |
| Second domain of FERM | 0.002061 | INHERITED FROM: cephalic nerve || gustatory system || peripheral nervous system || nerve |
| HMG-box | 0.00226 | INHERITED FROM: otic vesicle || retinal layer || midbrain-hindbrain boundary || forebrain || hindbrain || sensory system || spinal cord |
| ARM repeat | 0.002587 | INHERITED FROM: central nervous system |
| HLH, helix-loop-helix DNA-binding domain | 0.003345 | INHERITED FROM: retinal stem cell region || eye || otic vesicle || neural tube || cranial ganglion || chordoneural hinge || eye primordium || presumptive midbrain-hindbrain boundary || enteric nervous system || ganglion || optic vesicle || forebrain || retinal ganglion cell layer || retinal outer nuclear layer || lateral line || retinal inner plexiform layer || hindbrain || neural progenitor cell || retinal inner nuclear layer || peripheral nervous system || ventricular zone || lateral line system || neuron || olfactory system || sensory system || photoreceptor layer || spinal cord || midbrain || Rohon-Beard neuron |
| Tubulin C-terminal domain-like | 0.00432 | INHERITED FROM: intersomitic neuron || vagus nerve || spinal neuron || glossopharyngeal nerve || gustatory system || facial nerve || neuron || trigeminal nerve |
| UBC-like | 0.005243 | INHERITED FROM: central nervous system |
| Frizzled cysteine-rich domain | 0.009347 | INHERITED FROM: eye || otic vesicle || neural tube || cranial ganglion || midbrain-hindbrain boundary || ganglion || optic vesicle || forebrain || hindbrain || sensory system || vestibuloauditory system || midbrain |
| Tubulin nucleotide-binding domain-like | 0.02461 | INHERITED FROM: intersomitic neuron || vagus nerve || spinal neuron || glossopharyngeal nerve || gustatory system || facial nerve || neuron || trigeminal nerve |
| Transducin (alpha subunit), insertion domain | 0.05928 | INHERITED FROM: olfactory sensory neuron || olfactory epithelium || neuron || sensory system |
| PH domain-like | 0.06261 | INHERITED FROM: brain |
| Ras GEF | 0.09239 | INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer |
| Growth factor receptor domain | 0.1012 | INHERITED FROM: otic vesicle || neuromere || spinal cord |
| Spectrin repeat | 0.1062 | INHERITED FROM: auditory ossicle || inner ear || auditory hair cell || auditory apparatus |
| lambda repressor-like DNA-binding domains | 0.1149 | INHERITED FROM: neural tube || presumptive midbrain-hindbrain boundary || neuron || spinal cord |
| PYP-like sensor domain (PAS domain) | 0.1273 | INHERITED FROM: eye || visual system || sensory system || spinal cord |
| Voltage-gated potassium channels | 0.1496 | INHERITED FROM: retinal neural layer || optic disc || cephalic nerve || optic nerve || retinal ganglion cell layer || retinal inner plexiform layer || axon || neuron || nerve || spinal cord |
| Orange domain-like | 0.1585 | INHERITED FROM: trigeminal ganglion || eye || neural tube || chordoneural hinge || floor plate || ganglion || visual system || sensory system || spinal cord || midbrain |
| SET domain | 0.172 | INHERITED FROM: hindbrain |
| "Winged helix" DNA-binding domain | 0.2241 | INHERITED FROM: eye || otic vesicle || neural tube || sensory system || spinal cord |
| Galactose-binding domain-like | 0.3538 | INHERITED FROM: optic nerve |
| F-box domain | 0.3741 | INHERITED FROM: optic vesicle |
| Sema domain | 0.388 | INHERITED FROM: otic placode || presumptive midbrain-hindbrain boundary || sensory system |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.407 | INHERITED FROM: anterior hypothalamus || ventral pallium || diencephalon || lateral pallium || prosomere || subpallium || prosomere 4 || striatum || septum || pretectum || central nucleus of the thalamus || optic tectum || neuromere || basal ganglion || forebrain || lateral septum || ventral septum || hindbrain || neural nucleus || preoptic area || amygdala || medial septum || thalamus || hypothalamus || ventrolateral thalamic nucleus || spinal cord || zona limitans intrathalamica || basal forebrain || midbrain |
| FnI-like domain | 0.4336 | INHERITED FROM: neural tube |
| P-domain of calnexin/calreticulin | 0.4913 | INHERITED FROM: spinal cord |
| Plexin repeat | 0.5009 | INHERITED FROM: otic placode || presumptive midbrain-hindbrain boundary || sensory system |
| p53-like transcription factors | 0.6225 | INHERITED FROM: eye || facial nerve || neuron || sensory system |
| P-loop containing nucleoside triphosphate hydrolases | 0.6383 | INHERITED FROM: olfactory sensory neuron |
| Fibronectin type III | 0.6454 | INHERITED FROM: retinal neural layer || retinal ganglion cell layer || retinal inner nuclear layer |
| Kazal-type serine protease inhibitors | 0.6751 | INHERITED FROM: floor plate || spinal cord |
| DNA-binding domain | 0.7059 | INHERITED FROM: eye primordium |
| POZ domain | 0.787 | INHERITED FROM: optic disc || axon |
| Intermediate filament protein, coiled coil region | 0.88 | INHERITED FROM: retinal neural layer || cephalic nerve || spinal neuron || gustatory system || midbrain tegmentum || retinal ganglion cell || optic nerve || nucleus reticularis inferior || vestibulocochlear nerve || ganglion || retinal ganglion cell layer || retinal inner plexiform layer || retinal inner nuclear layer || peripheral nervous system || ventricular zone || neural nucleus || neuron || nerve || medulla oblongata || spinal ganglion |
| gamma-Crystallin-like | 0.9981 | INHERITED FROM: lens |
| Cystine-knot cytokines | 1 | INHERITED FROM: neural tube |
| EGF/Laminin | 1 | INHERITED FROM: floor plate || spinal cord |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: anterior hypothalamus || diencephalon || striatum || septum || pallium || granule cell layer of the olfactory bulb || basal ganglion || neural nucleus || preoptic area || amygdala || hypothalamus || medial pallium || basal forebrain |
| Immunoglobulin | 1 | INHERITED FROM: retinal inner nuclear layer |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Endosomal sorting complex assembly domain | 0 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| Acyl-CoA binding protein | 0 | Direct |
| Hedgehog/DD-peptidase | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Dimeric alpha+beta barrel | 0 | Direct |
| LuxS/MPP-like metallohydrolase | 0 | Direct |
| Hook domain | 0 | Direct |
| TNF receptor-like | 0 | Direct |
| Oligoxyloglucan reducing end-specific cellobiohydrolase | 0 | Direct |
| Nop domain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| Synuclein | 0 | Direct |
| RNase III domain-like | 0 | Direct |
| Sialidases | 0 | Direct |
| Mss4-like | 0 | Direct |
| Enolase C-terminal domain-like | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| MAST3 pre-PK domain-like | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| Aminomethyltransferase beta-barrel domain | 0 | Direct |
| Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| LeuD/IlvD-like | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
| GINS helical bundle-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| GYF domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| eIF1-like | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| USP8 N-terminal domain-like | 0 | Direct |
| DLC | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| I/LWEQ domain | 0 | Direct |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | Direct |
| post-AAA+ oligomerization domain-like | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| TGS-like | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| CCHHC domain | 0 | Direct |
| Families 57/38 glycoside transferase middle domain | 0 | Direct |
| ClpS-like | 0 | Direct |
| GroEL-intermediate domain like | 0 | Direct |
| BRK domain-like | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Glycoside hydrolase/deacetylase | 0 | Direct |
| Stathmin | 0 | Direct |
| SRF-like | 0 | Direct |
| ThrRS/AlaRS common domain | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| NAP-like | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| Glutamine synthetase/guanido kinase | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| PAH2 domain | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| BEACH domain | 0 | Direct |
| Tim10-like | 0 | Direct |
| Cysteine alpha-hairpin motif | 0 | Direct |
| Ligand-binding domain in the NO signalling and Golgi transport | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Mib/herc2 domain-like | 0 | Direct |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
| Pentein | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| AraD/HMP-PK domain-like | 0 | Direct |
| Enolase N-terminal domain-like | 0 | Direct |
| ACP-like | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| ARID-like | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| PriA/YqbF domain | 0 | Direct |
| Notch domain | 0 | Direct |
| Cytokine | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
| Homeodomain-like | 0.0004075 | Direct |
| Cadherin-like | 0.0005399 | Direct |
| Ubiquitin-like | 0.001267 | Inherited |
| RNA-binding domain, RBD | 0.001466 | Inherited |
| Second domain of FERM | 0.002061 | Inherited |
| HMG-box | 0.00226 | Inherited |
| ARM repeat | 0.002587 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.003345 | Inherited |
| Tubulin C-terminal domain-like | 0.00432 | Inherited |
| UBC-like | 0.005243 | Inherited |
| Frizzled cysteine-rich domain | 0.009347 | Inherited |
| Tubulin nucleotide-binding domain-like | 0.02461 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.05928 | Inherited |
| PH domain-like | 0.06261 | Inherited |
| Ras GEF | 0.09239 | Inherited |
| Growth factor receptor domain | 0.1012 | Inherited |
| Spectrin repeat | 0.1062 | Inherited |
| lambda repressor-like DNA-binding domains | 0.1149 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.1273 | Inherited |
| Voltage-gated potassium channels | 0.1496 | Inherited |
| Orange domain-like | 0.1585 | Inherited |
| SET domain | 0.172 | Inherited |
| "Winged helix" DNA-binding domain | 0.2241 | Inherited |
| Galactose-binding domain-like | 0.3538 | Inherited |
| F-box domain | 0.3741 | Inherited |
| Sema domain | 0.388 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.407 | Inherited |
| FnI-like domain | 0.4336 | Inherited |
| P-domain of calnexin/calreticulin | 0.4913 | Inherited |
| Plexin repeat | 0.5009 | Inherited |
| p53-like transcription factors | 0.6225 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 0.6383 | Inherited |
| Fibronectin type III | 0.6454 | Inherited |
| Kazal-type serine protease inhibitors | 0.6751 | Inherited |
| DNA-binding domain | 0.7059 | Inherited |
| POZ domain | 0.787 | Inherited |
| Intermediate filament protein, coiled coil region | 0.88 | Inherited |
| gamma-Crystallin-like | 0.9981 | Inherited |
| Cystine-knot cytokines | 1 | Inherited |
| EGF/Laminin | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
| Immunoglobulin | 1 | Inherited |
(show details)
Supra-domains annotated to this XA term (SPXA level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50998,50978
50998 - Quinoprotein alcohol dehydrogenase-like
50978 - WD40 repeat-like | 0 | DIRECT |
57184,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57196,100895
57196 - EGF/Laminin
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | DIRECT |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | DIRECT |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | DIRECT |
47473,57889
47473 - EF-hand
57889 - Cysteine-rich domain | 0 | DIRECT |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | DIRECT |
49313,49899
49313 - Cadherin-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | DIRECT |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | DIRECT |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
100895,47473
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand | 0 | DIRECT |
57535,49854
57535 - Complement control module/SCR domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | DIRECT |
56112,48371
56112 - Protein kinase-like (PK-like)
48371 - ARM repeat | 0 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | DIRECT |
49562,53300
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
53300 - vWA-like | 0 | DIRECT |
57535,57196
57535 - Complement control module/SCR domain
57196 - EGF/Laminin | 0 | DIRECT |
103025,101790
103025 - Folate-binding domain
101790 - Aminomethyltransferase beta-barrel domain | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0 | DIRECT |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | DIRECT |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | DIRECT |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
56491,89811
56491 - A heparin-binding domain
89811 - Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | DIRECT |
56436,57535
56436 - C-type lectin-like
57535 - Complement control module/SCR domain | 0 | DIRECT |
57184,49265
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | DIRECT |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
48065,103657
48065 - DBL homology domain (DH-domain)
103657 - BAR/IMD domain-like | 0 | DIRECT |
50729,57889
50729 - PH domain-like
57889 - Cysteine-rich domain | 0 | DIRECT |
81995,81811
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | DIRECT |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | DIRECT |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
53300,81995
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0 | DIRECT |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
47095,47095
47095 - HMG-box
47095 - HMG-box | 0 | DIRECT |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0 | DIRECT |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0 | DIRECT |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
48034,55931
48034 - Guanido kinase N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0 | DIRECT |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0 | DIRECT |
57424,57184
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | DIRECT |
49899,48726
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin | 0 | DIRECT |
50729,81837
50729 - PH domain-like
81837 - BEACH domain | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
47473,57850
47473 - EF-hand
57850 - RING/U-box | 0 | DIRECT |
48403,50044
48403 - Ankyrin repeat
50044 - SH3-domain | 0 | DIRECT |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
50044,50156
50044 - SH3-domain
50156 - PDZ domain-like | 0 | DIRECT |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | DIRECT |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0 | DIRECT |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
81271,55186
81271 - TGS-like
55186 - ThrRS/AlaRS common domain | 0 | DIRECT |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
48371,46785
48371 - ARM repeat
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
69065,54768
69065 - RNase III domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
51045,50156
51045 - WW domain
50156 - PDZ domain-like | 0 | DIRECT |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
54631,54631
54631 - CBS-domain pair
54631 - CBS-domain pair | 0 | DIRECT |
54160,57850
54160 - Chromo domain-like
57850 - RING/U-box | 0 | DIRECT |
88713,88688
88713 - Glycoside hydrolase/deacetylase
88688 - Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
47370,47370
47370 - Bromodomain
47370 - Bromodomain | 0 | DIRECT |
46565,57938
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
57184,100895
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
48350,50729
48350 - GTPase activation domain, GAP
50729 - PH domain-like | 0 | DIRECT |
52540,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain | 0 | DIRECT |
48726,56436
48726 - Immunoglobulin
56436 - C-type lectin-like | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | DIRECT |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
117281,50965
117281 - Kelch motif
50965 - Galactose oxidase, central domain | 0 | DIRECT |
103637,103637
103637 - CCHHC domain
103637 - CCHHC domain | 0 | DIRECT |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.0009262 | DIRECT |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.001398 | INHERITED FROM: central nervous system || visual system |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.00432 | INHERITED FROM: intersomitic neuron || vagus nerve || spinal neuron || glossopharyngeal nerve || gustatory system || facial nerve || neuron || trigeminal nerve |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.005648 | INHERITED FROM: ganglion || peripheral nervous system |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0.04604 | INHERITED FROM: spinal cord |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.05691 | INHERITED FROM: trigeminal ganglion || anterior hypothalamus || ventral pallium || cephalic nerve || lateral pallium || medial amygdala || prosomere || subpallium || prosomere 4 || striatum || otic vesicle || septum || pretectum || central nucleus of the thalamus || pallium || optic tectum || neuromere || basal ganglion || anterior thalamic nucleus || bed nucleus of the stria terminalis || forebrain || lateral septum || ventral septum || hindbrain || neural nucleus || preoptic area || amygdala || nerve || medial septum || thalamus || hypothalamus || sensory system || ventrolateral thalamic nucleus || zona limitans intrathalamica || basal forebrain |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.05928 | INHERITED FROM: olfactory sensory neuron || olfactory epithelium || neuron || sensory system |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.08978 | INHERITED FROM: auditory ossicle || inner ear || auditory hair cell || auditory apparatus |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.1585 | INHERITED FROM: trigeminal ganglion || eye || neural tube || chordoneural hinge || floor plate || ganglion || visual system || sensory system || spinal cord || midbrain |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0.1872 | INHERITED FROM: retinal neural layer || retinal ganglion cell layer || retinal inner nuclear layer || spinal cord |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.1978 | INHERITED FROM: eye || visual system || spinal cord |
57603,57603
57603 - FnI-like domain
57603 - FnI-like domain | 0.2009 | INHERITED FROM: spinal cord |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0.2544 | INHERITED FROM: neural tube || presumptive midbrain-hindbrain boundary || retinal ganglion cell layer || neuron |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.3159 | INHERITED FROM: otic vesicle || spinal cord || vestibuloauditory system |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.3159 | INHERITED FROM: otic vesicle || spinal cord || vestibuloauditory system |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.388 | INHERITED FROM: otic placode || presumptive midbrain-hindbrain boundary || sensory system |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.3963 | INHERITED FROM: visual system |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.4581 | INHERITED FROM: hindbrain || spinal cord |
49899,63887
49899 - Concanavalin A-like lectins/glucanases
63887 - P-domain of calnexin/calreticulin | 0.4913 | INHERITED FROM: spinal cord |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.5352 | INHERITED FROM: retinal neural layer || retinal ganglion cell layer || retinal inner nuclear layer || spinal cord |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0.6277 | INHERITED FROM: midbrain-hindbrain boundary |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.6277 | INHERITED FROM: optic vesicle |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.6344 | INHERITED FROM: retinal inner nuclear layer |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.7709 | INHERITED FROM: hypothalamus || spinal cord |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.7709 | INHERITED FROM: eye primordium || posterior neural tube |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50998,50978
50998 - Quinoprotein alcohol dehydrogenase-like
50978 - WD40 repeat-like | 0 | Direct |
57184,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57196,100895
57196 - EGF/Laminin
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | Direct |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | Direct |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | Direct |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | Direct |
47473,57889
47473 - EF-hand
57889 - Cysteine-rich domain | 0 | Direct |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | Direct |
49313,49899
49313 - Cadherin-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | Direct |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | Direct |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0 | Direct |
100895,47473
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand | 0 | Direct |
57535,49854
57535 - Complement control module/SCR domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | Direct |
56112,48371
56112 - Protein kinase-like (PK-like)
48371 - ARM repeat | 0 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | Direct |
49562,53300
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
53300 - vWA-like | 0 | Direct |
57535,57196
57535 - Complement control module/SCR domain
57196 - EGF/Laminin | 0 | Direct |
103025,101790
103025 - Folate-binding domain
101790 - Aminomethyltransferase beta-barrel domain | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0 | Direct |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | Direct |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | Direct |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | Direct |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
56491,89811
56491 - A heparin-binding domain
89811 - Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | Direct |
56436,57535
56436 - C-type lectin-like
57535 - Complement control module/SCR domain | 0 | Direct |
57184,49265
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | Direct |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
48065,103657
48065 - DBL homology domain (DH-domain)
103657 - BAR/IMD domain-like | 0 | Direct |
50729,57889
50729 - PH domain-like
57889 - Cysteine-rich domain | 0 | Direct |
81995,81811
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | Direct |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | Direct |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
53300,81995
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0 | Direct |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | Direct |
47095,47095
47095 - HMG-box
47095 - HMG-box | 0 | Direct |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0 | Direct |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0 | Direct |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
48034,55931
48034 - Guanido kinase N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0 | Direct |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0 | Direct |
57424,57184
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | Direct |
49899,48726
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin | 0 | Direct |
50729,81837
50729 - PH domain-like
81837 - BEACH domain | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
47473,57850
47473 - EF-hand
57850 - RING/U-box | 0 | Direct |
48403,50044
48403 - Ankyrin repeat
50044 - SH3-domain | 0 | Direct |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
50044,50156
50044 - SH3-domain
50156 - PDZ domain-like | 0 | Direct |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | Direct |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0 | Direct |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
81271,55186
81271 - TGS-like
55186 - ThrRS/AlaRS common domain | 0 | Direct |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
48371,46785
48371 - ARM repeat
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
69065,54768
69065 - RNase III domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | Direct |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | Direct |
51045,50156
51045 - WW domain
50156 - PDZ domain-like | 0 | Direct |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
54631,54631
54631 - CBS-domain pair
54631 - CBS-domain pair | 0 | Direct |
54160,57850
54160 - Chromo domain-like
57850 - RING/U-box | 0 | Direct |
88713,88688
88713 - Glycoside hydrolase/deacetylase
88688 - Families 57/38 glycoside transferase middle domain | 0 | Direct |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
47370,47370
47370 - Bromodomain
47370 - Bromodomain | 0 | Direct |
46565,57938
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
57184,100895
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
48350,50729
48350 - GTPase activation domain, GAP
50729 - PH domain-like | 0 | Direct |
52540,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain | 0 | Direct |
48726,56436
48726 - Immunoglobulin
56436 - C-type lectin-like | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | Direct |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
117281,50965
117281 - Kelch motif
50965 - Galactose oxidase, central domain | 0 | Direct |
103637,103637
103637 - CCHHC domain
103637 - CCHHC domain | 0 | Direct |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.0009262 | Direct |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.001398 | Inherited |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.00432 | Inherited |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.005648 | Inherited |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0.04604 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.05691 | Inherited |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.05928 | Inherited |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.08978 | Inherited |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.1585 | Inherited |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0.1872 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.1978 | Inherited |
57603,57603
57603 - FnI-like domain
57603 - FnI-like domain | 0.2009 | Inherited |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0.2544 | Inherited |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.3159 | Inherited |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.3159 | Inherited |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.388 | Inherited |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.3963 | Inherited |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.4581 | Inherited |
49899,63887
49899 - Concanavalin A-like lectins/glucanases
63887 - P-domain of calnexin/calreticulin | 0.4913 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.5352 | Inherited |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0.6277 | Inherited |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.6277 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.6344 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.7709 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.7709 | Inherited |
(show details)
Supra-domains annotated to this XA term (SPXA level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
49854,57535,57535
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
49899,57196,49899
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
57196,57196,49899
57196 - EGF/Laminin
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | DIRECT |
53300,81995,81811
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | DIRECT |
103657,50729,48350
103657 - BAR/IMD domain-like
50729 - PH domain-like
48350 - GTPase activation domain, GAP | 0 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
49899,57196,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
54768,54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
46565,57938,49493
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
63748,63748,63748
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT | 0 | DIRECT |
103637,103637,103637
103637 - CCHHC domain
103637 - CCHHC domain
103637 - CCHHC domain | 0 | DIRECT |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
81995,81811,82754
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
52058,52058,52058
52058 - L domain-like
52058 - L domain-like
52058 - L domain-like | 0 | DIRECT |
57535,49854,57535
57535 - Complement control module/SCR domain
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
47220,47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
48726,56436,56436
48726 - Immunoglobulin
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | DIRECT |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54160,57850,57845
54160 - Chromo domain-like
57850 - RING/U-box
57845 - B-box zinc-binding domain | 0 | DIRECT |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
49899,48726,49265
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | DIRECT |
48065,103657,50044
48065 - DBL homology domain (DH-domain)
103657 - BAR/IMD domain-like
50044 - SH3-domain | 0 | DIRECT |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
52540,51045,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain
51045 - WW domain | 0 | DIRECT |
49313,49313,49899
49313 - Cadherin-like
49313 - Cadherin-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | DIRECT |
49562,49562,53300
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
53300 - vWA-like | 0 | DIRECT |
57196,49899,57196
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0 | DIRECT |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.05716 | INHERITED FROM: floor plate |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0.1382 | INHERITED FROM: chordoneural hinge |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.1829 | INHERITED FROM: optic vesicle |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.238 | INHERITED FROM: auditory ossicle || inner ear || auditory hair cell || auditory apparatus |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0.3159 | INHERITED FROM: neural tube || spinal cord |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.3326 | INHERITED FROM: retinal ganglion cell layer || hindbrain || retinal inner nuclear layer || spinal cord |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.3939 | INHERITED FROM: otic vesicle || spinal cord || vestibuloauditory system |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.3963 | INHERITED FROM: eye || otic vesicle || forebrain || visual system || sensory system |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.4669 | INHERITED FROM: eye || visual system || sensory system || spinal cord |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.6203 | INHERITED FROM: neuron |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0.6277 | INHERITED FROM: midbrain-hindbrain boundary |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | Direct |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
49854,57535,57535
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
49899,57196,49899
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
57196,57196,49899
57196 - EGF/Laminin
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | Direct |
53300,81995,81811
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | Direct |
103657,50729,48350
103657 - BAR/IMD domain-like
50729 - PH domain-like
48350 - GTPase activation domain, GAP | 0 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
49899,57196,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
54768,54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
46565,57938,49493
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
63748,63748,63748
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT | 0 | Direct |
103637,103637,103637
103637 - CCHHC domain
103637 - CCHHC domain
103637 - CCHHC domain | 0 | Direct |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
81995,81811,82754
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
52058,52058,52058
52058 - L domain-like
52058 - L domain-like
52058 - L domain-like | 0 | Direct |
57535,49854,57535
57535 - Complement control module/SCR domain
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0 | Direct |
47220,47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
48726,56436,56436
48726 - Immunoglobulin
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | Direct |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54160,57850,57845
54160 - Chromo domain-like
57850 - RING/U-box
57845 - B-box zinc-binding domain | 0 | Direct |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
49899,48726,49265
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | Direct |
48065,103657,50044
48065 - DBL homology domain (DH-domain)
103657 - BAR/IMD domain-like
50044 - SH3-domain | 0 | Direct |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
52540,51045,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain
51045 - WW domain | 0 | Direct |
49313,49313,49899
49313 - Cadherin-like
49313 - Cadherin-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | Direct |
49562,49562,53300
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
53300 - vWA-like | 0 | Direct |
57196,49899,57196
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0 | Direct |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.05716 | Inherited |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0.1382 | Inherited |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.1829 | Inherited |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.238 | Inherited |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0.3159 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.3326 | Inherited |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.3939 | Inherited |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.3963 | Inherited |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.4669 | Inherited |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.6203 | Inherited |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0.6277 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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