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Xenopus ANatomical entity (XAN): primary germ layer
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: XA Hierarchy (Xenopus anatomy and development from Xenbase frog anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this XA term (Not in SDXA)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Nucleoplasmin-like core domain | 0 | DIRECT |
| C-terminal domain of adenylylcyclase associated protein | 0 | DIRECT |
| Translation proteins SH3-like domain | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| E2F-DP heterodimerization region | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| GINS helical bundle-like | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Mib/herc2 domain-like | 0 | DIRECT |
| PriA/YqbF domain | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| Ribonuclease PH domain 2-like | 0 | DIRECT |
| PAP/OAS1 substrate-binding domain | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Soluble quinoprotein glucose dehydrogenase | 0 | DIRECT |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| BSD domain-like | 0 | DIRECT |
| Uracil-DNA glycosylase-like | 0 | DIRECT |
| Hedgehog/DD-peptidase | 0 | DIRECT |
| ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| DLC | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Ribosomal proteins L15p and L18e | 0 | DIRECT |
| LuxS/MPP-like metallohydrolase | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Cytokine | 0 | DIRECT |
| Ribosomal L27 protein-like | 0 | DIRECT |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| PEBP-like | 0 | DIRECT |
| Homeodomain-like | 0.0000000005885 | DIRECT |
| RNA-binding domain, RBD | 0.0000737 | DIRECT |
| Nucleic acid-binding proteins | 0.0003467 | DIRECT |
| SET domain | 0.0005505 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0.003893 | INHERITED FROM: anterior neural ridge || intermediate mesoderm || neural groove || chordal neural plate border || pre-chordal neural plate || Rohon-Beard neuron || neural plate border || cranial placode || neural plate || tail fin || tail tip || caudal presomitic mesoderm || chordoneural hinge || anterior placodal area || sensorial layer || rostral presomitic mesoderm || anterior neural fold || hyoid crest || presomitic mesoderm || myotome || pre-chordal neural plate border || neural crest || chordal neural plate || neural fold || sensorial layer of neurectoderm || neuroectoderm || somite || optic field || mesoderm || cardiac neural crest || paraxial mesoderm || preplacodal ectoderm |
| "Winged helix" DNA-binding domain | 0.004564 | INHERITED FROM: intermediate mesoderm || pre-chordal neural plate || neural plate || vagal neural crest || tail fin || tail tip || hyoid crest || anterior branchial crest || head mesoderm || neural crest || branchial crest || sensorial layer of neurectoderm || neuroectoderm || cranial neural crest || optic field || preplacodal ectoderm |
| HMG-box | 0.01341 | INHERITED FROM: neurogenic placode || pre-chordal neural plate || neural plate border || mandibular crest || neural plate || endoderm || anterior neural fold || hyoid crest || anterior branchial crest || midbrain-hindbrain boundary || neural crest || chordal neural plate || neural fold || neuroectoderm || neuroectoderm outer layer || posterior branchial crest || cranial neural crest || optic field |
| GroEL-intermediate domain like | 0.02644 | INHERITED FROM: endomesoderm || anterior dorsal lateral plate region |
| GroEL equatorial domain-like | 0.02644 | INHERITED FROM: endomesoderm || anterior dorsal lateral plate region |
| Frizzled cysteine-rich domain | 0.07324 | INHERITED FROM: pre-chordal neural plate || neural plate || presumptive paraxial mesoderm || endoderm || tail fin || lateral plate mesoderm || tail tip || mouth primordium || anterior neural fold || midbrain-hindbrain boundary || presomitic mesoderm || neural fold || neuroectoderm || somite || optic field || stomodeal-hypophyseal primordium || mesoderm |
| Tubulin C-terminal domain-like | 0.08823 | INHERITED FROM: epidermal cell || non-neural ectoderm || gastrocoel roof plate || epidermis |
| Tubulin nucleotide-binding domain-like | 0.09272 | INHERITED FROM: epidermal cell || non-neural ectoderm || gastrocoel roof plate || epidermis |
| Cyclin-like | 0.09491 | INHERITED FROM: postmigratory neural crest cell |
| GroEL apical domain-like | 0.0986 | INHERITED FROM: anterior dorsal lateral plate region |
| lambda repressor-like DNA-binding domains | 0.1225 | INHERITED FROM: neurogenic placode || cranial placode || neural plate || chordal neural plate || neural fold || neuroectoderm |
| Cystine-knot cytokines | 0.1238 | INHERITED FROM: neural groove || neurogenic placode || endoderm || mouth primordium || vegetal endoderm || head mesoderm || neuroectoderm || ventral mesoderm || mesoderm |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.1911 | INHERITED FROM: cranial placode || anterior placodal area || archenteron floor || sensorial layer of neurectoderm || neuroectoderm || preplacodal ectoderm |
| Snake toxin-like | 0.2109 | INHERITED FROM: pre-chordal neural plate || neural plate || lateral plate mesoderm || head mesoderm || chordal neural plate || neuroectoderm || ventral mesoderm || mesoderm |
| Sema domain | 0.276 | INHERITED FROM: cranial placode || neural crest || neuroectoderm || cranial neural crest || otic placode |
| Actin-like ATPase domain | 0.2996 | INHERITED FROM: head somite |
| Intermediate filament protein, coiled coil region | 0.3254 | INHERITED FROM: epidermis |
| Protein kinase-like (PK-like) | 0.3355 | INHERITED FROM: head mesoderm |
| beta-beta-alpha zinc fingers | 0.4508 | INHERITED FROM: anterior neural ridge || chordal neural plate border || pre-chordal neural plate || pre-chordal neural plate border || chordal neural plate || neural fold || splanchnic layer of lateral plate mesoderm |
| Alpha-macroglobulin receptor domain | 0.4706 | INHERITED FROM: archenteron |
| TIMP-like | 0.4842 | INHERITED FROM: pre-chordal neural plate || endoderm || optic field || stomodeal-hypophyseal primordium |
| PYP-like sensor domain (PAS domain) | 0.5742 | INHERITED FROM: somite || mesoderm |
| Kazal-type serine protease inhibitors | 0.6177 | INHERITED FROM: neural groove || neural plate || hypochord |
| Plexin repeat | 0.6197 | INHERITED FROM: cranial placode || neural crest || neuroectoderm || cranial neural crest || otic placode |
| p53-like transcription factors | 0.6518 | INHERITED FROM: neurogenic placode || cranial placode || neural plate || neuroectoderm || mesoderm |
| Orange domain-like | 0.6663 | INHERITED FROM: intermediate mesoderm || neural groove || pre-chordal neural plate || cranial placode || fin || lateral plate mesoderm || tail tip || chordoneural hinge || anterior neural fold || presomitic mesoderm || neural fold || neuroectoderm || mesoderm || paraxial mesoderm |
| FnI-like domain | 0.7302 | INHERITED FROM: hypochord || endoderm || somite |
| Kringle-like | 0.732 | INHERITED FROM: neural groove |
| Tropomyosin | 0.7864 | INHERITED FROM: myotome || dermomyotome |
| Troponin coil-coiled subunits | 0.8002 | INHERITED FROM: mesoderm |
| Growth factor receptor domain | 0.9129 | INHERITED FROM: anterior neural ridge || hypochord || fin || tail tip || pre-chordal neural plate border |
| Integrin domains | 0.9292 | INHERITED FROM: fibroblast || mesodermal cell |
| Globin-like | 0.9815 | INHERITED FROM: hematopoietic stem cell || anterior dorsal lateral plate region |
| TSP-1 type 1 repeat | 1 | INHERITED FROM: hypochord |
| Hemopexin-like domain | 1 | INHERITED FROM: fibroblast || mesodermal cell |
| Metalloproteases ("zincins"), catalytic domain | 1 | INHERITED FROM: fibroblast || mesodermal cell |
| EGF/Laminin | 1 | INHERITED FROM: neural groove || hypochord |
| Cadherin-like | 1 | INHERITED FROM: neural crest |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Nucleoplasmin-like core domain | 0 | Direct |
| C-terminal domain of adenylylcyclase associated protein | 0 | Direct |
| Translation proteins SH3-like domain | 0 | Direct |
| PAH2 domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Synuclein | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| E2F-DP heterodimerization region | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Tim10-like | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| GINS helical bundle-like | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Mib/herc2 domain-like | 0 | Direct |
| PriA/YqbF domain | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| Ribonuclease PH domain 2-like | 0 | Direct |
| PAP/OAS1 substrate-binding domain | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| WGR domain-like | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| TSP type-3 repeat | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| Connexin43 | 0 | Direct |
| SIS domain | 0 | Direct |
| Soluble quinoprotein glucose dehydrogenase | 0 | Direct |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| BSD domain-like | 0 | Direct |
| Uracil-DNA glycosylase-like | 0 | Direct |
| Hedgehog/DD-peptidase | 0 | Direct |
| ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| DLC | 0 | Direct |
| Nop domain | 0 | Direct |
| Notch domain | 0 | Direct |
| Ribosomal proteins L15p and L18e | 0 | Direct |
| LuxS/MPP-like metallohydrolase | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
| SRF-like | 0 | Direct |
| Cytokine | 0 | Direct |
| Ribosomal L27 protein-like | 0 | Direct |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| PEBP-like | 0 | Direct |
| Homeodomain-like | 0.0000000005885 | Direct |
| RNA-binding domain, RBD | 0.0000737 | Direct |
| Nucleic acid-binding proteins | 0.0003467 | Direct |
| SET domain | 0.0005505 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0.003893 | Inherited |
| "Winged helix" DNA-binding domain | 0.004564 | Inherited |
| HMG-box | 0.01341 | Inherited |
| GroEL-intermediate domain like | 0.02644 | Inherited |
| GroEL equatorial domain-like | 0.02644 | Inherited |
| Frizzled cysteine-rich domain | 0.07324 | Inherited |
| Tubulin C-terminal domain-like | 0.08823 | Inherited |
| Tubulin nucleotide-binding domain-like | 0.09272 | Inherited |
| Cyclin-like | 0.09491 | Inherited |
| GroEL apical domain-like | 0.0986 | Inherited |
| lambda repressor-like DNA-binding domains | 0.1225 | Inherited |
| Cystine-knot cytokines | 0.1238 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.1911 | Inherited |
| Snake toxin-like | 0.2109 | Inherited |
| Sema domain | 0.276 | Inherited |
| Actin-like ATPase domain | 0.2996 | Inherited |
| Intermediate filament protein, coiled coil region | 0.3254 | Inherited |
| Protein kinase-like (PK-like) | 0.3355 | Inherited |
| beta-beta-alpha zinc fingers | 0.4508 | Inherited |
| Alpha-macroglobulin receptor domain | 0.4706 | Inherited |
| TIMP-like | 0.4842 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.5742 | Inherited |
| Kazal-type serine protease inhibitors | 0.6177 | Inherited |
| Plexin repeat | 0.6197 | Inherited |
| p53-like transcription factors | 0.6518 | Inherited |
| Orange domain-like | 0.6663 | Inherited |
| FnI-like domain | 0.7302 | Inherited |
| Kringle-like | 0.732 | Inherited |
| Tropomyosin | 0.7864 | Inherited |
| Troponin coil-coiled subunits | 0.8002 | Inherited |
| Growth factor receptor domain | 0.9129 | Inherited |
| Integrin domains | 0.9292 | Inherited |
| Globin-like | 0.9815 | Inherited |
| TSP-1 type 1 repeat | 1 | Inherited |
| Hemopexin-like domain | 1 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 1 | Inherited |
| EGF/Laminin | 1 | Inherited |
| Cadherin-like | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this XA term (Not in SDXA)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Hedgehog (development protein), N-terminal signaling domain | 0 | DIRECT |
| Ferritin | 0 | DIRECT |
| Trunk domain of Sec23/24 | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | DIRECT |
| IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
| MIF4G domain-like | 0 | DIRECT |
| Pumilio repeat | 0 | DIRECT |
| RNA-polymerase beta | 0 | DIRECT |
| ets domain | 0 | DIRECT |
| Mib/herc2 domain | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Phosphatidylethanolamine binding protein | 0 | DIRECT |
| E2F dimerization segment | 0 | DIRECT |
| HD domain | 0 | DIRECT |
| Thrombospondin C-terminal domain | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| Cell cycle transcription factor e2f-dp | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| HAT/Suf repeat | 0 | DIRECT |
| RUNT domain | 0 | DIRECT |
| Prefoldin | 0 | DIRECT |
| Guanido kinase catalytic domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| TRASH domain | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Paired domain | 0 | DIRECT |
| Pointed domain | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| MPP-like | 0 | DIRECT |
| Alpha-adaptin ear subdomain-like | 0 | DIRECT |
| IF2B-like | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| SIAH, seven in absentia homolog | 0 | DIRECT |
| RNA-polymerase beta-prime | 0 | DIRECT |
| PDI-like | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | DIRECT |
| LON domain-like | 0 | DIRECT |
| ATP-dependent DNA ligase catalytic domain | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| DLC | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Nucleoplasmin-like core domain | 0 | DIRECT |
| Alanine racemase-like, N-terminal domain | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | DIRECT |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
| Class II glutamine amidotransferases | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| N-type ATP pyrophosphatases | 0 | DIRECT |
| C-terminal domain of adenylylcyclase associated protein | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| ZZ domain | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| WGR domain | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| CAT-like | 0 | DIRECT |
| Noggin | 0 | DIRECT |
| Eukaryotic ODC-like | 0 | DIRECT |
| Tim10/DDP | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| Ribosomal proteins L15p and L18e | 0 | DIRECT |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| alpha-catenin/vinculin | 0 | DIRECT |
| Heat-shock transcription factor | 0 | DIRECT |
| A20-like zinc finger | 0 | DIRECT |
| ECR1 N-terminal domain-like | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| P4 origin-binding domain-like | 0 | DIRECT |
| Retinol binding protein-like | 0 | DIRECT |
| Ribonuclease PH domain 1-like | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| UBX domain | 0 | DIRECT |
| Pseudouridine synthase I TruA | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| BSD domain | 0 | DIRECT |
| Phosphoribosylpyrophosphate synthetase-like | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| Ribonuclease PH domain 2-like | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Ran-binding domain | 0 | DIRECT |
| S-adenosylhomocystein hydrolase | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| Fibroblast growth factors (FGF) | 0 | DIRECT |
| SH3BGR (SH3-binding, glutamic acid-rich protein-like) | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| Polo-box duplicated region | 0 | DIRECT |
| NLI interacting factor-like phosphatase | 0 | DIRECT |
| Serine carboxypeptidase-like | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
| GDI-like N domain | 0 | DIRECT |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | DIRECT |
| B56-like | 0 | DIRECT |
| Homeodomain | 0.000000006336 | DIRECT |
| Canonical RBD | 0.00003185 | DIRECT |
| PHD domain | 0.0005119 | DIRECT |
| Histone lysine methyltransferases | 0.0007048 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0.003475 | INHERITED FROM: anterior neural ridge || intermediate mesoderm || neural groove || chordal neural plate border || pre-chordal neural plate || Rohon-Beard neuron || neural plate border || cranial placode || neural plate || tail fin || tail tip || caudal presomitic mesoderm || chordoneural hinge || anterior placodal area || sensorial layer || rostral presomitic mesoderm || anterior neural fold || hyoid crest || presomitic mesoderm || myotome || pre-chordal neural plate border || chordal neural plate || neural fold || sensorial layer of neurectoderm || neuroectoderm || somite || optic field || mesoderm || cardiac neural crest || paraxial mesoderm || preplacodal ectoderm |
| Cyclin | 0.01085 | INHERITED FROM: postmigratory neural crest cell || migratory neural crest cell |
| Forkhead DNA-binding domain | 0.01155 | INHERITED FROM: anterior neural ridge || pre-chordal neural plate || neural plate || vagal neural crest || tail fin || tail tip || chordoneural hinge || anterior placodal area || anterior neural fold || presomitic mesoderm || pre-chordal neural plate border || head mesoderm || neural crest || neural fold || sensorial layer of neurectoderm || neuroectoderm || optic field || mesoderm || ciliated epidermal cell || preplacodal ectoderm |
| HMG-box | 0.01155 | INHERITED FROM: neurogenic placode || pre-chordal neural plate || neural plate border || mandibular crest || neural plate || endoderm || anterior neural fold || hyoid crest || anterior branchial crest || midbrain-hindbrain boundary || neural fold || neuroectoderm || neuroectoderm outer layer || posterior branchial crest || cranial neural crest || optic field |
| POU-specific domain | 0.02831 | INHERITED FROM: neurogenic placode || pre-chordal neural plate || neural plate || chordal neural plate || neural fold || neuroectoderm |
| Group II chaperonin (CCT, TRIC), apical domain | 0.03952 | INHERITED FROM: anterior dorsal lateral plate region |
| Transforming growth factor (TGF)-beta | 0.05467 | INHERITED FROM: neurogenic placode || endoderm || mouth primordium || vegetal endoderm || head mesoderm || gastrocoel roof plate || ventral mesoderm || mesoderm |
| Frizzled cysteine-rich domain | 0.06368 | INHERITED FROM: pre-chordal neural plate || neural plate || presumptive paraxial mesoderm || endoderm || tail fin || lateral plate mesoderm || tail tip || mouth primordium || anterior neural fold || midbrain-hindbrain boundary || presomitic mesoderm || neural fold || neuroectoderm || somite || optic field || stomodeal-hypophyseal primordium || mesoderm |
| Sema domain | 0.0692 | INHERITED FROM: cranial placode || neural plate || midbrain-hindbrain boundary || neural crest || neuroectoderm || cranial neural crest || otic placode |
| Tubulin, GTPase domain | 0.07684 | INHERITED FROM: epidermal cell || non-neural ectoderm || gastrocoel roof plate || epidermis |
| Tubulin, C-terminal domain | 0.07684 | INHERITED FROM: epidermal cell || non-neural ectoderm || gastrocoel roof plate || epidermis |
| Cell cycle control phosphatase, catalytic domain | 0.09957 | INHERITED FROM: neural plate || chordal neural plate || neuroectoderm |
| T-box | 0.1334 | INHERITED FROM: neurogenic placode || mesoderm |
| Glutathione peroxidase-like | 0.1907 | INHERITED FROM: presumptive paraxial mesoderm || presomitic mesoderm || cranial neural crest || paraxial mesoderm |
| Actin/HSP70 | 0.2376 | INHERITED FROM: head somite || trunk somite || head mesoderm |
| VWC domain | 0.2679 | INHERITED FROM: hypochord || endoderm || mesoderm |
| Intermediate filament protein, coiled coil region | 0.3065 | INHERITED FROM: epidermis |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.3436 | INHERITED FROM: somite || mesoderm |
| Multidrug efflux transporter AcrB transmembrane domain | 0.3669 | INHERITED FROM: epidermis |
| Ephrin ectodomain | 0.3669 | INHERITED FROM: sensorial layer of neurectoderm |
| Arginine methyltransferase | 0.3669 | INHERITED FROM: cranial neural crest |
| LIM domain | 0.3701 | INHERITED FROM: cranial placode |
| Complement components | 0.3745 | INHERITED FROM: endoderm |
| Alpha-macroglobulin receptor domain | 0.4418 | INHERITED FROM: archenteron |
| Erythroid transcription factor GATA-1 | 0.4418 | INHERITED FROM: archenteron || endoderm || lateral plate mesoderm || archenteron floor || hematopoietic stem cell || anterior dorsal lateral plate region || mesoderm |
| L domain | 0.4418 | INHERITED FROM: somite || mesoderm |
| Classic zinc finger, C2H2 | 0.4504 | INHERITED FROM: anterior neural ridge || chordal neural plate border || pre-chordal neural plate || neural plate border || anterior neural fold || pre-chordal neural plate border || chordal neural plate || neural fold || splanchnic layer of lateral plate mesoderm |
| Ephrin receptor ligand binding domain | 0.459 | INHERITED FROM: branchial crest |
| Protein kinases, catalytic subunit | 0.4822 | INHERITED FROM: head mesoderm |
| Parvalbumin | 0.519 | INHERITED FROM: somite |
| Plexin repeat | 0.6303 | INHERITED FROM: cranial placode || neural crest || neuroectoderm || cranial neural crest || otic placode |
| Hairy Orange domain | 0.6359 | INHERITED FROM: intermediate mesoderm || neural groove || pre-chordal neural plate || cranial placode || fin || lateral plate mesoderm || tail tip || chordoneural hinge || anterior neural fold || presomitic mesoderm || neural fold || neuroectoderm || mesoderm || paraxial mesoderm |
| Ovomucoid domain III-like | 0.6359 | INHERITED FROM: neural groove || neural plate || hypochord |
| Matrix metalloproteases, catalytic domain | 0.7014 | INHERITED FROM: fibroblast || mesodermal cell |
| Kringle modules | 0.7159 | INHERITED FROM: neural groove |
| Tropomyosin | 0.7458 | INHERITED FROM: myotome || dermomyotome |
| Growth factor receptor domain | 0.7879 | INHERITED FROM: hypochord || fin || mesoderm |
| Integrin domains | 0.9247 | INHERITED FROM: fibroblast || mesodermal cell |
| Globins | 0.958 | INHERITED FROM: hematopoietic stem cell || anterior dorsal lateral plate region |
| Hemopexin-like domain | 1 | INHERITED FROM: fibroblast || mesodermal cell |
| TSP-1 type 1 repeat | 1 | INHERITED FROM: hypochord |
| Calmodulin-like | 1 | INHERITED FROM: ciliated epidermal cell |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Hedgehog (development protein), N-terminal signaling domain | 0 | Direct |
| Ferritin | 0 | Direct |
| Trunk domain of Sec23/24 | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | Direct |
| IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
| MIF4G domain-like | 0 | Direct |
| Pumilio repeat | 0 | Direct |
| RNA-polymerase beta | 0 | Direct |
| ets domain | 0 | Direct |
| Mib/herc2 domain | 0 | Direct |
| NTF2-like | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Phosphatidylethanolamine binding protein | 0 | Direct |
| E2F dimerization segment | 0 | Direct |
| HD domain | 0 | Direct |
| Thrombospondin C-terminal domain | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| Cell cycle transcription factor e2f-dp | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| HAT/Suf repeat | 0 | Direct |
| RUNT domain | 0 | Direct |
| Prefoldin | 0 | Direct |
| Guanido kinase catalytic domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| TRASH domain | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Paired domain | 0 | Direct |
| Pointed domain | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| MPP-like | 0 | Direct |
| Alpha-adaptin ear subdomain-like | 0 | Direct |
| IF2B-like | 0 | Direct |
| SRF-like | 0 | Direct |
| Notch domain | 0 | Direct |
| SIAH, seven in absentia homolog | 0 | Direct |
| RNA-polymerase beta-prime | 0 | Direct |
| PDI-like | 0 | Direct |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | Direct |
| LON domain-like | 0 | Direct |
| ATP-dependent DNA ligase catalytic domain | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| DLC | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Nucleoplasmin-like core domain | 0 | Direct |
| Alanine racemase-like, N-terminal domain | 0 | Direct |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | Direct |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
| Class II glutamine amidotransferases | 0 | Direct |
| SMAD domain | 0 | Direct |
| N-type ATP pyrophosphatases | 0 | Direct |
| C-terminal domain of adenylylcyclase associated protein | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| ZZ domain | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| WGR domain | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| CAT-like | 0 | Direct |
| Noggin | 0 | Direct |
| Eukaryotic ODC-like | 0 | Direct |
| Tim10/DDP | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| Ribosomal proteins L15p and L18e | 0 | Direct |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | Direct |
| PAH2 domain | 0 | Direct |
| alpha-catenin/vinculin | 0 | Direct |
| Heat-shock transcription factor | 0 | Direct |
| A20-like zinc finger | 0 | Direct |
| ECR1 N-terminal domain-like | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| P4 origin-binding domain-like | 0 | Direct |
| Retinol binding protein-like | 0 | Direct |
| Ribonuclease PH domain 1-like | 0 | Direct |
| Connexin43 | 0 | Direct |
| UBX domain | 0 | Direct |
| Pseudouridine synthase I TruA | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| BSD domain | 0 | Direct |
| Phosphoribosylpyrophosphate synthetase-like | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| Ribonuclease PH domain 2-like | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Ran-binding domain | 0 | Direct |
| S-adenosylhomocystein hydrolase | 0 | Direct |
| Nop domain | 0 | Direct |
| Fibroblast growth factors (FGF) | 0 | Direct |
| SH3BGR (SH3-binding, glutamic acid-rich protein-like) | 0 | Direct |
| Synuclein | 0 | Direct |
| TSP type-3 repeat | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| Polo-box duplicated region | 0 | Direct |
| NLI interacting factor-like phosphatase | 0 | Direct |
| Serine carboxypeptidase-like | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
| GDI-like N domain | 0 | Direct |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | Direct |
| B56-like | 0 | Direct |
| Homeodomain | 0.000000006336 | Direct |
| Canonical RBD | 0.00003185 | Direct |
| PHD domain | 0.0005119 | Direct |
| Histone lysine methyltransferases | 0.0007048 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0.003475 | Inherited |
| Cyclin | 0.01085 | Inherited |
| Forkhead DNA-binding domain | 0.01155 | Inherited |
| HMG-box | 0.01155 | Inherited |
| POU-specific domain | 0.02831 | Inherited |
| Group II chaperonin (CCT, TRIC), apical domain | 0.03952 | Inherited |
| Transforming growth factor (TGF)-beta | 0.05467 | Inherited |
| Frizzled cysteine-rich domain | 0.06368 | Inherited |
| Sema domain | 0.0692 | Inherited |
| Tubulin, GTPase domain | 0.07684 | Inherited |
| Tubulin, C-terminal domain | 0.07684 | Inherited |
| Cell cycle control phosphatase, catalytic domain | 0.09957 | Inherited |
| T-box | 0.1334 | Inherited |
| Glutathione peroxidase-like | 0.1907 | Inherited |
| Actin/HSP70 | 0.2376 | Inherited |
| VWC domain | 0.2679 | Inherited |
| Intermediate filament protein, coiled coil region | 0.3065 | Inherited |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.3436 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.3669 | Inherited |
| Ephrin ectodomain | 0.3669 | Inherited |
| Arginine methyltransferase | 0.3669 | Inherited |
| LIM domain | 0.3701 | Inherited |
| Complement components | 0.3745 | Inherited |
| Alpha-macroglobulin receptor domain | 0.4418 | Inherited |
| Erythroid transcription factor GATA-1 | 0.4418 | Inherited |
| L domain | 0.4418 | Inherited |
| Classic zinc finger, C2H2 | 0.4504 | Inherited |
| Ephrin receptor ligand binding domain | 0.459 | Inherited |
| Protein kinases, catalytic subunit | 0.4822 | Inherited |
| Parvalbumin | 0.519 | Inherited |
| Plexin repeat | 0.6303 | Inherited |
| Hairy Orange domain | 0.6359 | Inherited |
| Ovomucoid domain III-like | 0.6359 | Inherited |
| Matrix metalloproteases, catalytic domain | 0.7014 | Inherited |
| Kringle modules | 0.7159 | Inherited |
| Tropomyosin | 0.7458 | Inherited |
| Growth factor receptor domain | 0.7879 | Inherited |
| Integrin domains | 0.9247 | Inherited |
| Globins | 0.958 | Inherited |
| Hemopexin-like domain | 1 | Inherited |
| TSP-1 type 1 repeat | 1 | Inherited |
| Calmodulin-like | 1 | Inherited |
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this XA term (Not in SPXA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| Hedgehog/DD-peptidase | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| LuxS/MPP-like metallohydrolase | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| PEBP-like | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Nucleoplasmin-like core domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
| GINS helical bundle-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| E2F-DP heterodimerization region | 0 | DIRECT |
| DLC | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | DIRECT |
| Uracil-DNA glycosylase-like | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| Soluble quinoprotein glucose dehydrogenase | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| Ribosomal L27 protein-like | 0 | DIRECT |
| BSD domain-like | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| Ribosomal proteins L15p and L18e | 0 | DIRECT |
| Ribonuclease PH domain 2-like | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| Mib/herc2 domain-like | 0 | DIRECT |
| C-terminal domain of adenylylcyclase associated protein | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| Translation proteins SH3-like domain | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| PriA/YqbF domain | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Cytokine | 0 | DIRECT |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
| PAP/OAS1 substrate-binding domain | 0 | DIRECT |
| Homeodomain-like | 0.0000000004106 | DIRECT |
| RNA-binding domain, RBD | 0.0000542 | DIRECT |
| Nucleic acid-binding proteins | 0.0002595 | DIRECT |
| SET domain | 0.0004145 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0.003001 | INHERITED FROM: neural plate || anterior neural ridge || chordoneural hinge || intermediate mesoderm || paraxial mesoderm || neural crest || hyoid crest || sensorial layer of neurectoderm || rostral presomitic mesoderm || somite || myotome || chordal neural plate border || cardiac neural crest || mesoderm || mandibular crest || Rohon-Beard neuron || optic field || anterior neural fold || presomitic mesoderm || neural fold || cranial placode || caudal presomitic mesoderm || tail fin || preplacodal ectoderm || chordal neural plate || pre-chordal neural plate border || pre-chordal neural plate || neural plate border || sensorial layer || neural groove || tail tip || anterior placodal area || neuroectoderm |
| "Winged helix" DNA-binding domain | 0.00353 | INHERITED FROM: neural plate || intermediate mesoderm || neural crest || hyoid crest || sensorial layer of neurectoderm || head mesoderm || optic field || anterior branchial crest || tail fin || preplacodal ectoderm || cranial neural crest || branchial crest || vagal neural crest || pre-chordal neural plate || tail tip || anterior placodal area || neuroectoderm |
| HMG-box | 0.01055 | INHERITED FROM: midbrain-hindbrain boundary || neural plate || neural crest || neuroectoderm outer layer || hyoid crest || mandibular crest || optic field || anterior branchial crest || anterior neural fold || neurogenic placode || neural fold || cranial neural crest || chordal neural plate || branchial crest || endoderm || posterior placodal area || pre-chordal neural plate || neural plate border || posterior branchial crest || neuroectoderm |
| GroEL-intermediate domain like | 0.02115 | INHERITED FROM: endomesoderm || anterior dorsal lateral plate region |
| GroEL equatorial domain-like | 0.02115 | INHERITED FROM: endomesoderm || anterior dorsal lateral plate region |
| Frizzled cysteine-rich domain | 0.06093 | INHERITED FROM: midbrain-hindbrain boundary || stomodeal-hypophyseal primordium || neural plate || somite || mesoderm || presumptive paraxial mesoderm || optic field || lateral plate mesoderm || anterior neural fold || presomitic mesoderm || neural fold || tail fin || endoderm || pre-chordal neural plate || tail tip || mouth primordium || neuroectoderm |
| Tubulin C-terminal domain-like | 0.07396 | INHERITED FROM: epidermis || non-neural ectoderm || gastrocoel roof plate || epidermal cell |
| Tubulin nucleotide-binding domain-like | 0.07809 | INHERITED FROM: epidermis || non-neural ectoderm || gastrocoel roof plate || epidermal cell |
| Cyclin-like | 0.08015 | INHERITED FROM: postmigratory neural crest cell |
| GroEL apical domain-like | 0.0834 | INHERITED FROM: anterior dorsal lateral plate region |
| lambda repressor-like DNA-binding domains | 0.1052 | INHERITED FROM: neural plate || neurogenic placode || neural fold || cranial placode || chordal neural plate || neuroectoderm |
| Cystine-knot cytokines | 0.1064 | INHERITED FROM: ventral mesoderm || head mesoderm || mesoderm || neurogenic placode || endoderm || vegetal endoderm || neural groove || mouth primordium || neuroectoderm |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.1682 | INHERITED FROM: sensorial layer of neurectoderm || archenteron floor || cranial placode || preplacodal ectoderm || post-anal gut || anterior placodal area || neuroectoderm |
| Snake toxin-like | 0.1867 | INHERITED FROM: neural plate || ventral mesoderm || head mesoderm || mesoderm || dorsal lateral plate mesoderm || lateral plate mesoderm || chordal neural plate || pre-chordal neural plate || neuroectoderm |
| Sema domain | 0.2482 | INHERITED FROM: neural crest || cranial placode || cranial neural crest || otic placode || neuroectoderm |
| Actin-like ATPase domain | 0.271 | INHERITED FROM: head somite |
| Intermediate filament protein, coiled coil region | 0.2958 | INHERITED FROM: epidermis |
| Protein kinase-like (PK-like) | 0.3055 | INHERITED FROM: head mesoderm |
| beta-beta-alpha zinc fingers | 0.4173 | INHERITED FROM: anterior neural ridge || chordal neural plate border || neural fold || splanchnic layer of lateral plate mesoderm || chordal neural plate || pre-chordal neural plate border || pre-chordal neural plate |
| Alpha-macroglobulin receptor domain | 0.4364 | INHERITED FROM: archenteron |
| TIMP-like | 0.4497 | INHERITED FROM: stomodeal-hypophyseal primordium || optic field || endoderm || pre-chordal neural plate |
| PYP-like sensor domain (PAS domain) | 0.538 | INHERITED FROM: somite || mesoderm |
| Kazal-type serine protease inhibitors | 0.5818 | INHERITED FROM: neural plate || hypochord || neural groove |
| Plexin repeat | 0.5837 | INHERITED FROM: neural crest || cranial placode || cranial neural crest || otic placode || neuroectoderm |
| p53-like transcription factors | 0.6157 | INHERITED FROM: neural plate || mesoderm || neurogenic placode || cranial placode || neuroectoderm |
| Orange domain-like | 0.6307 | INHERITED FROM: chordoneural hinge || intermediate mesoderm || fin || paraxial mesoderm || mesoderm || lateral plate mesoderm || anterior neural fold || presomitic mesoderm || neural fold || cranial placode || pre-chordal neural plate || neural plate border || neural groove || tail tip || neuroectoderm |
| FnI-like domain | 0.6955 | INHERITED FROM: somite || hypochord || endoderm |
| Kringle-like | 0.6971 | INHERITED FROM: neural groove |
| Tropomyosin | 0.7532 | INHERITED FROM: myotome || dermomyotome |
| Troponin coil-coiled subunits | 0.7685 | INHERITED FROM: mesoderm |
| Growth factor receptor domain | 0.8848 | INHERITED FROM: anterior neural ridge || fin || hypochord || pre-chordal neural plate border || tail tip |
| Integrin domains | 0.9009 | INHERITED FROM: mesodermal cell || fibroblast |
| Globin-like | 0.9554 | INHERITED FROM: lateral plate mesoderm || hematopoietic stem cell || anterior dorsal lateral plate region |
| EGF/Laminin | 1 | INHERITED FROM: dorsal fin || hypochord || neural groove |
| TSP-1 type 1 repeat | 1 | INHERITED FROM: hypochord |
| Metalloproteases ("zincins"), catalytic domain | 1 | INHERITED FROM: mesodermal cell || fibroblast |
| Hemopexin-like domain | 1 | INHERITED FROM: mesodermal cell || fibroblast |
| Cadherin-like | 1 | INHERITED FROM: neural crest || neuroectoderm |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Zn-binding ribosomal proteins | 0 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| Hedgehog/DD-peptidase | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| LuxS/MPP-like metallohydrolase | 0 | Direct |
| TSP type-3 repeat | 0 | Direct |
| Nop domain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| Synuclein | 0 | Direct |
| PEBP-like | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Nucleoplasmin-like core domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| SIS domain | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Connexin43 | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
| GINS helical bundle-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| E2F-DP heterodimerization region | 0 | Direct |
| DLC | 0 | Direct |
| WGR domain-like | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | Direct |
| Uracil-DNA glycosylase-like | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| Soluble quinoprotein glucose dehydrogenase | 0 | Direct |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
| Ribosomal L27 protein-like | 0 | Direct |
| BSD domain-like | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| SRF-like | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| Ribosomal proteins L15p and L18e | 0 | Direct |
| Ribonuclease PH domain 2-like | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| PAH2 domain | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Tim10-like | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| Mib/herc2 domain-like | 0 | Direct |
| C-terminal domain of adenylylcyclase associated protein | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| Translation proteins SH3-like domain | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| PriA/YqbF domain | 0 | Direct |
| Notch domain | 0 | Direct |
| Cytokine | 0 | Direct |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
| PAP/OAS1 substrate-binding domain | 0 | Direct |
| Homeodomain-like | 0.0000000004106 | Direct |
| RNA-binding domain, RBD | 0.0000542 | Direct |
| Nucleic acid-binding proteins | 0.0002595 | Direct |
| SET domain | 0.0004145 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0.003001 | Inherited |
| "Winged helix" DNA-binding domain | 0.00353 | Inherited |
| HMG-box | 0.01055 | Inherited |
| GroEL-intermediate domain like | 0.02115 | Inherited |
| GroEL equatorial domain-like | 0.02115 | Inherited |
| Frizzled cysteine-rich domain | 0.06093 | Inherited |
| Tubulin C-terminal domain-like | 0.07396 | Inherited |
| Tubulin nucleotide-binding domain-like | 0.07809 | Inherited |
| Cyclin-like | 0.08015 | Inherited |
| GroEL apical domain-like | 0.0834 | Inherited |
| lambda repressor-like DNA-binding domains | 0.1052 | Inherited |
| Cystine-knot cytokines | 0.1064 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.1682 | Inherited |
| Snake toxin-like | 0.1867 | Inherited |
| Sema domain | 0.2482 | Inherited |
| Actin-like ATPase domain | 0.271 | Inherited |
| Intermediate filament protein, coiled coil region | 0.2958 | Inherited |
| Protein kinase-like (PK-like) | 0.3055 | Inherited |
| beta-beta-alpha zinc fingers | 0.4173 | Inherited |
| Alpha-macroglobulin receptor domain | 0.4364 | Inherited |
| TIMP-like | 0.4497 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.538 | Inherited |
| Kazal-type serine protease inhibitors | 0.5818 | Inherited |
| Plexin repeat | 0.5837 | Inherited |
| p53-like transcription factors | 0.6157 | Inherited |
| Orange domain-like | 0.6307 | Inherited |
| FnI-like domain | 0.6955 | Inherited |
| Kringle-like | 0.6971 | Inherited |
| Tropomyosin | 0.7532 | Inherited |
| Troponin coil-coiled subunits | 0.7685 | Inherited |
| Growth factor receptor domain | 0.8848 | Inherited |
| Integrin domains | 0.9009 | Inherited |
| Globin-like | 0.9554 | Inherited |
| EGF/Laminin | 1 | Inherited |
| TSP-1 type 1 repeat | 1 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 1 | Inherited |
| Hemopexin-like domain | 1 | Inherited |
| Cadherin-like | 1 | Inherited |
(show details)
Supra-domains annotated to this XA term (Not in SPXA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
103647,49899
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
88723,47807
88723 - PIN domain-like
47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | DIRECT |
110324,50249
110324 - Ribosomal L27 protein-like
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | DIRECT |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | DIRECT |
46966,47473
46966 - Spectrin repeat
47473 - EF-hand | 0 | DIRECT |
51230,47005
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
142921,47587
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
52425,48173
52425 - Cryptochrome/photolyase, N-terminal domain
48173 - Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0 | DIRECT |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | DIRECT |
57184,49265
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | DIRECT |
47005,52777
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
81995,81811
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | DIRECT |
81296,48239
81296 - E set domains
48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
53300,81995
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0 | DIRECT |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
47095,47095
47095 - HMG-box
47095 - HMG-box | 0 | DIRECT |
48034,55931
48034 - Guanido kinase N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0 | DIRECT |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0 | DIRECT |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | DIRECT |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
48371,46785
48371 - ARM repeat
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
54631,54631
54631 - CBS-domain pair
54631 - CBS-domain pair | 0 | DIRECT |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | DIRECT |
55486,48371
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | DIRECT |
46565,57938
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | DIRECT |
57184,100895
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.0003262 | DIRECT |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.001023 | INHERITED FROM: postmigratory neural crest cell || migratory neural crest cell |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0.05636 | INHERITED FROM: midbrain-hindbrain boundary || neural crest || cranial placode || cranial neural crest || branchial crest || neuroectoderm |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0.06773 | INHERITED FROM: cranial neural crest || neuroectoderm |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.07396 | INHERITED FROM: epidermis || non-neural ectoderm || gastrocoel roof plate || epidermal cell |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0.1401 | INHERITED FROM: neural plate || neurogenic placode || neural fold || cranial placode || chordal neural plate || neuroectoderm |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.1435 | INHERITED FROM: mesoderm || endoderm || neuroectoderm |
57603,57603
57603 - FnI-like domain
57603 - FnI-like domain | 0.1768 | INHERITED FROM: chordal neural plate |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.1816 | INHERITED FROM: sensorial layer of neurectoderm || archenteron floor || archenteron || cranial placode || preplacodal ectoderm || endoderm || post-anal gut || anterior dorsal lateral plate region || anterior placodal area || neuroectoderm |
64593,64593
64593 - Intermediate filament protein, coiled coil region
64593 - Intermediate filament protein, coiled coil region | 0.2235 | INHERITED FROM: epidermis |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.2413 | INHERITED FROM: head somite |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.2482 | INHERITED FROM: neural crest || cranial placode || cranial neural crest || otic placode || neuroectoderm |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.3037 | INHERITED FROM: neural plate || anterior neural ridge || chordal neural plate border || lateral plate mesoderm || anterior neural fold || neural fold || splanchnic layer of lateral plate mesoderm || chordal neural plate || pre-chordal neural plate border || pre-chordal neural plate || neural plate border || neuroectoderm |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.3109 | INHERITED FROM: somite |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.3733 | INHERITED FROM: somite |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.3968 | INHERITED FROM: non-involuting marginal zone |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.4364 | INHERITED FROM: somite || mesoderm |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.4364 | INHERITED FROM: somite || mesoderm |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0.5134 | INHERITED FROM: stomodeal-hypophyseal primordium || neural plate || mesoderm || optic field || endoderm || pre-chordal neural plate || neuroectoderm |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0.5521 | INHERITED FROM: cranial neural crest || branchial crest |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.6307 | INHERITED FROM: chordoneural hinge || intermediate mesoderm || fin || paraxial mesoderm || mesoderm || lateral plate mesoderm || anterior neural fold || presomitic mesoderm || neural fold || cranial placode || pre-chordal neural plate || neural plate border || neural groove || tail tip || neuroectoderm |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.8402 | INHERITED FROM: neurogenic placode |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.9198 | INHERITED FROM: neural groove |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.9655 | INHERITED FROM: non-involuting marginal zone |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.9862 | INHERITED FROM: presomitic mesoderm |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 1 | INHERITED FROM: neural crest |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
103647,49899
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
88723,47807
88723 - PIN domain-like
47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | Direct |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | Direct |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | Direct |
110324,50249
110324 - Ribosomal L27 protein-like
50249 - Nucleic acid-binding proteins | 0 | Direct |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | Direct |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0 | Direct |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | Direct |
46966,47473
46966 - Spectrin repeat
47473 - EF-hand | 0 | Direct |
51230,47005
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
142921,47587
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase | 0 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | Direct |
52425,48173
52425 - Cryptochrome/photolyase, N-terminal domain
48173 - Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0 | Direct |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | Direct |
57184,49265
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | Direct |
47005,52777
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | Direct |
81995,81811
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | Direct |
81296,48239
81296 - E set domains
48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
53300,81995
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0 | Direct |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
47095,47095
47095 - HMG-box
47095 - HMG-box | 0 | Direct |
48034,55931
48034 - Guanido kinase N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0 | Direct |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0 | Direct |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | Direct |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
48371,46785
48371 - ARM repeat
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
54631,54631
54631 - CBS-domain pair
54631 - CBS-domain pair | 0 | Direct |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | Direct |
55486,48371
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | Direct |
46565,57938
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | Direct |
57184,100895
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | Direct |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.0003262 | Direct |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.001023 | Inherited |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0.05636 | Inherited |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0.06773 | Inherited |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.07396 | Inherited |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0.1401 | Inherited |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.1435 | Inherited |
57603,57603
57603 - FnI-like domain
57603 - FnI-like domain | 0.1768 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.1816 | Inherited |
64593,64593
64593 - Intermediate filament protein, coiled coil region
64593 - Intermediate filament protein, coiled coil region | 0.2235 | Inherited |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.2413 | Inherited |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.2482 | Inherited |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.3037 | Inherited |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.3109 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.3733 | Inherited |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.3968 | Inherited |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.4364 | Inherited |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.4364 | Inherited |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0.5134 | Inherited |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0.5521 | Inherited |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.6307 | Inherited |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.8402 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.9198 | Inherited |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.9655 | Inherited |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.9862 | Inherited |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 1 | Inherited |
(show details)
Supra-domains annotated to this XA term (Not in SPXA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
63737,55486,48371
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | DIRECT |
57196,57196,49899
57196 - EGF/Laminin
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
53300,81995,81811
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
54768,54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
46565,57938,49493
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
103647,103647,49899
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
81995,81811,82754
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
142921,47587,56399
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | DIRECT |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
47220,47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
47769,47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | DIRECT |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
51230,47005,52777
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
103647,103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | DIRECT |
46966,46966,47473
46966 - Spectrin repeat
46966 - Spectrin repeat
47473 - EF-hand | 0 | DIRECT |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0.05636 | INHERITED FROM: midbrain-hindbrain boundary || neural crest || cranial placode || cranial neural crest || branchial crest || neuroectoderm |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.0834 | INHERITED FROM: sensorial layer of neurectoderm || anterior neural fold || presomitic mesoderm || tail tip || anterior placodal area |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.3109 | INHERITED FROM: neural plate || mesoderm || anterior neural fold || non-involuting marginal zone || neural fold || pre-chordal neural plate || neuroectoderm |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.3109 | INHERITED FROM: somite |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.3231 | INHERITED FROM: non-neurogenic ectodermal placode |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0.3692 | INHERITED FROM: chordoneural hinge || trunk somite || tail somite || tail tip |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.5134 | INHERITED FROM: mesoderm |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.5134 | INHERITED FROM: paraxial mesoderm || presomitic mesoderm |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.8449 | INHERITED FROM: splanchnic layer of lateral plate mesoderm |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 1 | INHERITED FROM: neural crest || neuroectoderm |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
63737,55486,48371
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | Direct |
57196,57196,49899
57196 - EGF/Laminin
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
53300,81995,81811
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
54768,54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
46565,57938,49493
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
103647,103647,49899
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
81995,81811,82754
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
142921,47587,56399
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | Direct |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
47220,47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
47769,47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | Direct |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
51230,47005,52777
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | Direct |
103647,103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | Direct |
46966,46966,47473
46966 - Spectrin repeat
46966 - Spectrin repeat
47473 - EF-hand | 0 | Direct |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0.05636 | Inherited |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.0834 | Inherited |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.3109 | Inherited |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.3109 | Inherited |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.3231 | Inherited |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0.3692 | Inherited |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.5134 | Inherited |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.5134 | Inherited |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.8449 | Inherited |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 1 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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