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Xenopus ANatomical entity (XAN): multi-tissue structure
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: XA Hierarchy (Xenopus anatomy and development from Xenbase frog anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this XA term (SDXA level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Hedgehog (development protein), N-terminal signaling domain | 0 | DIRECT |
PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | DIRECT |
Homeodomain | 0 | DIRECT |
SMAD MH1 domain | 0 | DIRECT |
14-3-3 protein | 0 | DIRECT |
RUNT domain | 0 | DIRECT |
Guanido kinase catalytic domain | 0 | DIRECT |
Transducin (alpha subunit), insertion domain | 0 | DIRECT |
Paired domain | 0 | DIRECT |
Pointed domain | 0 | DIRECT |
Extracellular domain of cell surface receptors | 0 | DIRECT |
Guanido kinase N-terminal domain | 0 | DIRECT |
Alanine racemase-like, N-terminal domain | 0 | DIRECT |
SMAD domain | 0 | DIRECT |
Arrestin/Vps26-like | 0 | DIRECT |
HLH, helix-loop-helix DNA-binding domain | 0 | DIRECT |
Moesin tail domain | 0 | DIRECT |
Noggin | 0 | DIRECT |
Eukaryotic ODC-like | 0 | DIRECT |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
Cyclin A/CDK2-associated p19, Skp2 | 0 | DIRECT |
L domain | 0 | DIRECT |
Nop domain | 0 | DIRECT |
Synuclein | 0 | DIRECT |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
Forkhead DNA-binding domain | 0.000000000006004 | DIRECT |
ets domain | 0.000000004055 | DIRECT |
Frizzled cysteine-rich domain | 0.000001702 | DIRECT |
Fibroblast growth factors (FGF) | 0.000005435 | DIRECT |
Intermediate filament protein, coiled coil region | 0.00001702 | DIRECT |
Tubulin, GTPase domain | 0.00002749 | DIRECT |
Tubulin, C-terminal domain | 0.00002749 | DIRECT |
Growth factor receptor domain | 0.00003182 | DIRECT |
Canonical RBD | 0.00003505 | DIRECT |
HMG-box | 0.000187 | DIRECT |
Sema domain | 0.0003376 | DIRECT |
T-box | 0.0008034 | DIRECT |
Hairy Orange domain | 0.001462 | INHERITED FROM: floor plate || chordoneural hinge || midbrain |
POU-specific domain | 0.0021 | INHERITED FROM: pronephric tubule || distal tubule || retinal ganglion cell layer || proximal tubule || late distal tubule || early distal tubule || pronephric duct |
Transforming growth factor (TGF)-beta | 0.003022 | INHERITED FROM: branchial arch 3 || branchial arch 1 || branchial arch 2 || dorsal aorta || aorta || mouth primordium || early distal tubule || branchial arch 4 || trunk vasculature |
I set domains | 0.00316 | INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer |
LIM domain | 0.00364 | INHERITED FROM: ventrolateral thalamic nucleus || prosomere || amygdala || septum || medial amygdala || ventral septum || bed nucleus of the stria terminalis || basal forebrain || thalamus || central nucleus of the thalamus || prosomere 4 || anterior thalamic nucleus || pretectum |
Hypoxia-inducible factor Hif2a, C-terminal domain | 0.005232 | INHERITED FROM: pronephric tubule || pronephric nephron |
Plexin repeat | 0.005826 | INHERITED FROM: branchial arch |
BRK domain-like | 0.007887 | INHERITED FROM: forebrain || hindbrain || midbrain |
ARID domain | 0.01267 | INHERITED FROM: pronephric tubule |
Histone lysine methyltransferases | 0.01955 | INHERITED FROM: hindbrain |
Ovomucoid domain III-like | 0.04445 | INHERITED FROM: floor plate |
Classic zinc finger, C2H2 | 0.0616 | INHERITED FROM: hindbrain || midbrain |
AAT-like | 0.06297 | INHERITED FROM: pronephric duct |
Class I aldolase | 0.07145 | INHERITED FROM: pronephric kidney |
Glutathione peroxidase-like | 0.07424 | INHERITED FROM: pronephric tubule || pronephric nephron || distal tubule || proximal tubule || early distal tubule || early proximal tubule |
Tropomyosin | 0.09126 | INHERITED FROM: outflow tract |
Crystallins/Ca-binding development proteins | 0.1072 | INHERITED FROM: lens |
Tandem AAA-ATPase domain | 0.1229 | INHERITED FROM: forebrain || hindbrain || midbrain |
Multidrug efflux transporter AcrB transmembrane domain | 0.1515 | INHERITED FROM: epidermis |
Fibronectin type III | 0.1847 | INHERITED FROM: retinal ganglion cell layer || retinal neural layer |
Higher-molecular-weight phosphotyrosine protein phosphatases | 0.3656 | INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer |
Voltage-gated potassium channels | 0.5236 | INHERITED FROM: retinal inner plexiform layer |
Tetramerization domain of potassium channels | 0.6007 | INHERITED FROM: retinal ganglion cell layer || retinal outer plexiform layer || retinal inner plexiform layer |
TSP-1 type 1 repeat | 0.7201 | INHERITED FROM: rectal diverticulum |
Calmodulin-like | 0.8231 | INHERITED FROM: ciliated epidermal cell |
Rhodopsin-like | 0.9337 | INHERITED FROM: amygdala || septum || granule cell layer of the olfactory bulb || basal forebrain || medial pallium || pallium || anterior hypothalamus || preoptic area || diencephalon || eye photoreceptor cell || striatum || basal ganglion || hypothalamus |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Hedgehog (development protein), N-terminal signaling domain | 0 | Direct |
PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | Direct |
Homeodomain | 0 | Direct |
SMAD MH1 domain | 0 | Direct |
14-3-3 protein | 0 | Direct |
RUNT domain | 0 | Direct |
Guanido kinase catalytic domain | 0 | Direct |
Transducin (alpha subunit), insertion domain | 0 | Direct |
Paired domain | 0 | Direct |
Pointed domain | 0 | Direct |
Extracellular domain of cell surface receptors | 0 | Direct |
Guanido kinase N-terminal domain | 0 | Direct |
Alanine racemase-like, N-terminal domain | 0 | Direct |
SMAD domain | 0 | Direct |
Arrestin/Vps26-like | 0 | Direct |
HLH, helix-loop-helix DNA-binding domain | 0 | Direct |
Moesin tail domain | 0 | Direct |
Noggin | 0 | Direct |
Eukaryotic ODC-like | 0 | Direct |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
Cyclin A/CDK2-associated p19, Skp2 | 0 | Direct |
L domain | 0 | Direct |
Nop domain | 0 | Direct |
Synuclein | 0 | Direct |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
Forkhead DNA-binding domain | 0.000000000006004 | Direct |
ets domain | 0.000000004055 | Direct |
Frizzled cysteine-rich domain | 0.000001702 | Direct |
Fibroblast growth factors (FGF) | 0.000005435 | Direct |
Intermediate filament protein, coiled coil region | 0.00001702 | Direct |
Tubulin, GTPase domain | 0.00002749 | Direct |
Tubulin, C-terminal domain | 0.00002749 | Direct |
Growth factor receptor domain | 0.00003182 | Direct |
Canonical RBD | 0.00003505 | Direct |
HMG-box | 0.000187 | Direct |
Sema domain | 0.0003376 | Direct |
T-box | 0.0008034 | Direct |
Hairy Orange domain | 0.001462 | Inherited |
POU-specific domain | 0.0021 | Inherited |
Transforming growth factor (TGF)-beta | 0.003022 | Inherited |
I set domains | 0.00316 | Inherited |
LIM domain | 0.00364 | Inherited |
Hypoxia-inducible factor Hif2a, C-terminal domain | 0.005232 | Inherited |
Plexin repeat | 0.005826 | Inherited |
BRK domain-like | 0.007887 | Inherited |
ARID domain | 0.01267 | Inherited |
Histone lysine methyltransferases | 0.01955 | Inherited |
Ovomucoid domain III-like | 0.04445 | Inherited |
Classic zinc finger, C2H2 | 0.0616 | Inherited |
AAT-like | 0.06297 | Inherited |
Class I aldolase | 0.07145 | Inherited |
Glutathione peroxidase-like | 0.07424 | Inherited |
Tropomyosin | 0.09126 | Inherited |
Crystallins/Ca-binding development proteins | 0.1072 | Inherited |
Tandem AAA-ATPase domain | 0.1229 | Inherited |
Multidrug efflux transporter AcrB transmembrane domain | 0.1515 | Inherited |
Fibronectin type III | 0.1847 | Inherited |
Higher-molecular-weight phosphotyrosine protein phosphatases | 0.3656 | Inherited |
Voltage-gated potassium channels | 0.5236 | Inherited |
Tetramerization domain of potassium channels | 0.6007 | Inherited |
TSP-1 type 1 repeat | 0.7201 | Inherited |
Calmodulin-like | 0.8231 | Inherited |
Rhodopsin-like | 0.9337 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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Supra-domain (including individual superfamily)
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Supra-domains annotated to this XA term (SPXA level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,53254 52540 - P-loop containing nucleoside triphosphate hydrolases 53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
51419,50621 51419 - PLP-binding barrel 50621 - Alanine racemase C-terminal domain-like | 0 | DIRECT |
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain | 0 | DIRECT |
52058,49265 52058 - L domain-like 49265 - Fibronectin type III | 0 | DIRECT |
56436,57535 56436 - C-type lectin-like 57535 - Complement control module/SCR domain | 0 | DIRECT |
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like | 0 | DIRECT |
57184,49265 57184 - Growth factor receptor domain 49265 - Fibronectin type III | 0 | DIRECT |
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48034,55931 48034 - Guanido kinase N-terminal domain 55931 - Glutamine synthetase/guanido kinase | 0 | DIRECT |
50044,50156 50044 - SH3-domain 50156 - PDZ domain-like | 0 | DIRECT |
57184,100895 57184 - Growth factor receptor domain 100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
48726,56436 48726 - Immunoglobulin 56436 - C-type lectin-like | 0 | DIRECT |
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.000004865 | DIRECT |
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like | 0.0000114 | DIRECT |
55785,55785 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) | 0.0002879 | DIRECT |
101912,103575 101912 - Sema domain 103575 - Plexin repeat | 0.0003043 | DIRECT |
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) | 0.0004349 | DIRECT |
57440,57440 57440 - Kringle-like 57440 - Kringle-like | 0.0004997 | DIRECT |
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like | 0.0009139 | DIRECT |
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD | 0.0032 | INHERITED FROM: pharyngeal arch |
64593,64593 64593 - Intermediate filament protein, coiled coil region 64593 - Intermediate filament protein, coiled coil region | 0.01904 | INHERITED FROM: epidermis |
49899,63887 49899 - Concanavalin A-like lectins/glucanases 63887 - P-domain of calnexin/calreticulin | 0.01904 | INHERITED FROM: pharyngeal arch |
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like | 0.02015 | INHERITED FROM: retinal ganglion cell layer || pronephric tubule |
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain | 0.02576 | INHERITED FROM: hypothalamus |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.03096 | INHERITED FROM: retinal neural layer || retinal inner nuclear layer || retinal ganglion cell layer |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.04497 | INHERITED FROM: hindbrain |
52799,52799 52799 - (Phosphotyrosine protein) phosphatases II 52799 - (Phosphotyrosine protein) phosphatases II | 0.05458 | INHERITED FROM: retinal neural layer || retinal inner nuclear layer || retinal ganglion cell layer |
53300,53300 53300 - vWA-like 53300 - vWA-like | 0.05598 | INHERITED FROM: blood vessel |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.06445 | INHERITED FROM: head vasculature |
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III | 0.1399 | INHERITED FROM: retinal inner nuclear layer |
82895,82895 82895 - TSP-1 type 1 repeat 82895 - TSP-1 type 1 repeat | 0.8577 | INHERITED FROM: rectal diverticulum |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,53254 52540 - P-loop containing nucleoside triphosphate hydrolases 53254 - Phosphoglycerate mutase-like | 0 | Direct |
51419,50621 51419 - PLP-binding barrel 50621 - Alanine racemase C-terminal domain-like | 0 | Direct |
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain | 0 | Direct |
52058,49265 52058 - L domain-like 49265 - Fibronectin type III | 0 | Direct |
56436,57535 56436 - C-type lectin-like 57535 - Complement control module/SCR domain | 0 | Direct |
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like | 0 | Direct |
57184,49265 57184 - Growth factor receptor domain 49265 - Fibronectin type III | 0 | Direct |
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48034,55931 48034 - Guanido kinase N-terminal domain 55931 - Glutamine synthetase/guanido kinase | 0 | Direct |
50044,50156 50044 - SH3-domain 50156 - PDZ domain-like | 0 | Direct |
57184,100895 57184 - Growth factor receptor domain 100895 - Kazal-type serine protease inhibitors | 0 | Direct |
48726,56436 48726 - Immunoglobulin 56436 - C-type lectin-like | 0 | Direct |
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.000004865 | Direct |
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like | 0.0000114 | Direct |
55785,55785 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) | 0.0002879 | Direct |
101912,103575 101912 - Sema domain 103575 - Plexin repeat | 0.0003043 | Direct |
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) | 0.0004349 | Direct |
57440,57440 57440 - Kringle-like 57440 - Kringle-like | 0.0004997 | Direct |
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like | 0.0009139 | Direct |
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD | 0.0032 | Inherited |
64593,64593 64593 - Intermediate filament protein, coiled coil region 64593 - Intermediate filament protein, coiled coil region | 0.01904 | Inherited |
49899,63887 49899 - Concanavalin A-like lectins/glucanases 63887 - P-domain of calnexin/calreticulin | 0.01904 | Inherited |
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like | 0.02015 | Inherited |
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain | 0.02576 | Inherited |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.03096 | Inherited |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.04497 | Inherited |
52799,52799 52799 - (Phosphotyrosine protein) phosphatases II 52799 - (Phosphotyrosine protein) phosphatases II | 0.05458 | Inherited |
53300,53300 53300 - vWA-like 53300 - vWA-like | 0.05598 | Inherited |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.06445 | Inherited |
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III | 0.1399 | Inherited |
82895,82895 82895 - TSP-1 type 1 repeat 82895 - TSP-1 type 1 repeat | 0.8577 | Inherited |
(show details)
Supra-domains annotated to this XA term (SPXA level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain | 0 | DIRECT |
52058,49265,49265 52058 - L domain-like 49265 - Fibronectin type III 49265 - Fibronectin type III | 0 | DIRECT |
57440,57440,57440 57440 - Kringle-like 57440 - Kringle-like 57440 - Kringle-like | 0 | DIRECT |
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like | 0 | DIRECT |
48726,56436,56436 48726 - Immunoglobulin 56436 - C-type lectin-like 56436 - C-type lectin-like | 0 | DIRECT |
57184,52058,49265 57184 - Growth factor receptor domain 52058 - L domain-like 49265 - Fibronectin type III | 0 | DIRECT |
47459,55785,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) | 0.00003972 | DIRECT |
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like | 0.000694 | DIRECT |
48371,48371,48371 48371 - ARM repeat 48371 - ARM repeat 48371 - ARM repeat | 0.002159 | INHERITED FROM: chordoneural hinge |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.002706 | INHERITED FROM: retinal inner nuclear layer || hindbrain || retinal ganglion cell layer |
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.003228 | INHERITED FROM: branchial arch || forebrain |
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.01409 | INHERITED FROM: floor plate |
90257,90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments 90257 - Myosin rod fragments | 0.02356 | INHERITED FROM: branchial arch |
49899,57196,57196 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.02356 | INHERITED FROM: diencephalon |
57196,57196,49899 57196 - EGF/Laminin 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases | 0.06244 | INHERITED FROM: diencephalon || retinal neural layer || retina |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain | 0 | Direct |
52058,49265,49265 52058 - L domain-like 49265 - Fibronectin type III 49265 - Fibronectin type III | 0 | Direct |
57440,57440,57440 57440 - Kringle-like 57440 - Kringle-like 57440 - Kringle-like | 0 | Direct |
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like | 0 | Direct |
48726,56436,56436 48726 - Immunoglobulin 56436 - C-type lectin-like 56436 - C-type lectin-like | 0 | Direct |
57184,52058,49265 57184 - Growth factor receptor domain 52058 - L domain-like 49265 - Fibronectin type III | 0 | Direct |
47459,55785,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) | 0.00003972 | Direct |
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like | 0.000694 | Direct |
48371,48371,48371 48371 - ARM repeat 48371 - ARM repeat 48371 - ARM repeat | 0.002159 | Inherited |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.002706 | Inherited |
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.003228 | Inherited |
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.01409 | Inherited |
90257,90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments 90257 - Myosin rod fragments | 0.02356 | Inherited |
49899,57196,57196 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.02356 | Inherited |
57196,57196,49899 57196 - EGF/Laminin 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases | 0.06244 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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