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Xenopus ANatomical entity (XAN): tissue
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: XA Hierarchy (Xenopus anatomy and development from Xenbase frog anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this XA term (SDXA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
Nucleoplasmin-like core domain | 0 | DIRECT |
SAP domain | 0 | DIRECT |
Cap-Gly domain | 0 | DIRECT |
Aconitase iron-sulfur domain | 0 | DIRECT |
Sec63 N-terminal domain-like | 0 | DIRECT |
Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
C-terminal domain of adenylylcyclase associated protein | 0 | DIRECT |
Translation proteins SH3-like domain | 0 | DIRECT |
PAH2 domain | 0 | DIRECT |
Succinyl-CoA synthetase domains | 0 | DIRECT |
DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
RBP11-like subunits of RNA polymerase | 0 | DIRECT |
Sialidases | 0 | DIRECT |
L-aspartase-like | 0 | DIRECT |
Synuclein | 0 | DIRECT |
beta-sandwich domain of Sec23/24 | 0 | DIRECT |
KA1-like | 0 | DIRECT |
GFP-like | 0 | DIRECT |
Mitochondrial cytochrome c oxidase subunit VIIa | 0 | DIRECT |
Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
E2F-DP heterodimerization region | 0 | DIRECT |
Troponin coil-coiled subunits | 0 | DIRECT |
F1F0 ATP synthase subunit C | 0 | DIRECT |
4Fe-4S ferredoxins | 0 | DIRECT |
Helical domain of Sec23/24 | 0 | DIRECT |
Tim10-like | 0 | DIRECT |
Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
BRK domain-like | 0 | DIRECT |
Clathrin adaptor appendage domain | 0 | DIRECT |
HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
Orange domain-like | 0 | DIRECT |
Moesin tail domain | 0 | DIRECT |
NTF2-like | 0 | DIRECT |
Fibrinogen coiled-coil and central regions | 0 | DIRECT |
post-AAA+ oligomerization domain-like | 0 | DIRECT |
Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
Mediator hinge subcomplex-like | 0 | DIRECT |
Nucleoporin domain | 0 | DIRECT |
Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
NAP-like | 0 | DIRECT |
LeuD/IlvD-like | 0 | DIRECT |
Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
GINS helical bundle-like | 0 | DIRECT |
Arginase/deacetylase | 0 | DIRECT |
Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
HSP90 C-terminal domain | 0 | DIRECT |
Endosomal sorting complex assembly domain | 0 | DIRECT |
Mib/herc2 domain-like | 0 | DIRECT |
N-acetylmuramoyl-L-alanine amidase-like | 0 | DIRECT |
CoA-dependent acyltransferases | 0 | DIRECT |
PriA/YqbF domain | 0 | DIRECT |
alpha-catenin/vinculin-like | 0 | DIRECT |
DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
Guanido kinase N-terminal domain | 0 | DIRECT |
Class I glutamine amidotransferase-like | 0 | DIRECT |
Ribulose-phoshate binding barrel | 0 | DIRECT |
MIR domain | 0 | DIRECT |
eIF4e-like | 0 | DIRECT |
Zn-binding ribosomal proteins | 0 | DIRECT |
Subunits of heterodimeric actin filament capping protein Capz | 0 | DIRECT |
Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
Trefoil | 0 | DIRECT |
BAG domain | 0 | DIRECT |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
Alpha-macroglobulin receptor domain | 0 | DIRECT |
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
FAS1 domain | 0 | DIRECT |
Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
Ribonuclease PH domain 2-like | 0 | DIRECT |
Proteasome activator | 0 | DIRECT |
PAP/OAS1 substrate-binding domain | 0 | DIRECT |
PLP-binding barrel | 0 | DIRECT |
Apolipoprotein A-I | 0 | DIRECT |
Surp module (SWAP domain) | 0 | DIRECT |
Phosphoglucomutase, first 3 domains | 0 | DIRECT |
FF domain | 0 | DIRECT |
WGR domain-like | 0 | DIRECT |
SPOC domain-like | 0 | DIRECT |
TSP type-3 repeat | 0 | DIRECT |
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
Connexin43 | 0 | DIRECT |
HRDC-like | 0 | DIRECT |
SIS domain | 0 | DIRECT |
Ferritin-like | 0 | DIRECT |
Soluble quinoprotein glucose dehydrogenase | 0 | DIRECT |
Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
TK C-terminal domain-like | 0 | DIRECT |
SMAD MH1 domain | 0 | DIRECT |
Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | DIRECT |
BSD domain-like | 0 | DIRECT |
G protein-binding domain | 0 | DIRECT |
Uracil-DNA glycosylase-like | 0 | DIRECT |
GYF domain | 0 | DIRECT |
Hedgehog/DD-peptidase | 0 | DIRECT |
ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
TAFH domain-like | 0 | DIRECT |
Zn-finger domain of Sec23/24 | 0 | DIRECT |
Alanine racemase C-terminal domain-like | 0 | DIRECT |
ADP-ribosylglycohydrolase | 0 | DIRECT |
DLC | 0 | DIRECT |
Nop domain | 0 | DIRECT |
Notch domain | 0 | DIRECT |
Ribosomal proteins L15p and L18e | 0 | DIRECT |
LuxS/MPP-like metallohydrolase | 0 | DIRECT |
Ribosomal protein L10-like | 0 | DIRECT |
Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
SRF-like | 0 | DIRECT |
Bromodomain | 0 | DIRECT |
Cytokine | 0 | DIRECT |
Acyl-CoA binding protein | 0 | DIRECT |
FMT C-terminal domain-like | 0 | DIRECT |
Ribosomal L27 protein-like | 0 | DIRECT |
Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
Di-copper centre-containing domain | 0 | DIRECT |
14-3-3 protein | 0 | DIRECT |
PEBP-like | 0 | DIRECT |
RNA-binding domain, RBD | 0.000004542 | DIRECT |
Homeodomain-like | 0.00001111 | DIRECT |
"Winged helix" DNA-binding domain | 0.00004771 | DIRECT |
Nucleic acid-binding proteins | 0.0002581 | DIRECT |
HLH, helix-loop-helix DNA-binding domain | 0.0003919 | DIRECT |
UBC-like | 0.01607 | INHERITED FROM: bone tissue |
Thioredoxin-like | 0.02091 | INHERITED FROM: early proximal tubule || connective tissue || bone tissue || skeletal tissue |
Cyclin-like | 0.02537 | INHERITED FROM: postmigratory neural crest cell |
SET domain | 0.03878 | INHERITED FROM: primary germ layer |
Actin depolymerizing proteins | 0.05426 | INHERITED FROM: connective tissue || bone tissue || skeletal tissue |
HSP20-like chaperones | 0.0589 | INHERITED FROM: skeletal muscle |
HMG-box | 0.06139 | INHERITED FROM: optic field || retinal layer || otic vesicle || endocardium || neural plate || neural plate border || pre-chordal neural plate || neural fold || neuroectoderm outer layer || chordal neural plate || midbrain-hindbrain boundary || anterior branchial crest || anterior neural fold || endoderm || blastocoel floor || cranial neural crest || posterior branchial crest || neuroectoderm || mandibular crest || neurogenic placode || neural crest || hyoid crest |
ARID-like | 0.1027 | INHERITED FROM: pronephric tubule |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0.1027 | INHERITED FROM: skeletal muscle |
Glucocorticoid receptor-like (DNA-binding domain) | 0.1149 | INHERITED FROM: zona limitans intrathalamica || cranial placode || preplacodal ectoderm || neuroectoderm || sensorial layer of neurectoderm || proximal tubule branch || archenteron floor || anterior placodal area |
GroEL equatorial domain-like | 0.1235 | INHERITED FROM: skeletal muscle || anterior dorsal lateral plate region || endomesoderm || muscle |
Actin-like ATPase domain | 0.1279 | INHERITED FROM: skeletal muscle || jaw muscle || myocyte || cranial muscle || head somite |
p53-like transcription factors | 0.1348 | INHERITED FROM: neural plate || cranial placode || regenerating tissue || blastema || notochord || primary heart field || myocardium || cartilage tissue || neuroectoderm || mesenchyme || facial nerve || neurogenic placode || mesoderm || involuted ventral mesoderm |
Tubulin C-terminal domain-like | 0.1385 | INHERITED FROM: epidermis || epithelial cell || gastrocoel roof plate || epithelium || trigeminal nerve || facial nerve || vagus nerve || epidermal cell || glossopharyngeal nerve || non-neural ectoderm |
Thiolase-like | 0.1655 | INHERITED FROM: skeletal muscle |
GroEL-intermediate domain like | 0.1655 | INHERITED FROM: skeletal muscle || anterior dorsal lateral plate region || endomesoderm || muscle |
Transducin (alpha subunit), insertion domain | 0.2407 | INHERITED FROM: olfactory epithelium || olfactory sensory neuron |
Spectrin repeat | 0.2409 | INHERITED FROM: epithelial cell || sensory epithelial cell || auditory hair cell |
Tubulin nucleotide-binding domain-like | 0.2599 | INHERITED FROM: epidermis || epithelial cell || gastrocoel roof plate || epithelium || trigeminal nerve || facial nerve || vagus nerve || epidermal cell || glossopharyngeal nerve || non-neural ectoderm |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.2659 | INHERITED FROM: skeletal muscle |
Hemopexin-like domain | 0.3017 | INHERITED FROM: notochord || mesodermal cell || fibroblast |
GroEL apical domain-like | 0.3252 | INHERITED FROM: skeletal muscle || anterior dorsal lateral plate region || muscle |
Myosin rod fragments | 0.35 | INHERITED FROM: musculature of face |
SMAD/FHA domain | 0.355 | INHERITED FROM: endocardium |
Frizzled cysteine-rich domain | 0.3607 | INHERITED FROM: stomodeal-hypophyseal primordium || optic field || otic vesicle || tail tip || neural plate || pre-chordal neural plate || involuted dorsal mesoderm || neural fold || somite || presomitic mesoderm || midbrain-hindbrain boundary || anterior neural fold || tail fin || endoderm || neuroectoderm || mesenchyme || mouth primordium || mesoderm || lateral plate mesoderm || presumptive paraxial mesoderm |
Clavaminate synthase-like | 0.3776 | INHERITED FROM: late proximal tubule || late distal tubule |
Phosphoglycerate mutase-like | 0.3823 | INHERITED FROM: head mesenchyme || notochord || mesenchyme |
Annexin | 0.4029 | INHERITED FROM: bone tissue |
LDH C-terminal domain-like | 0.4084 | INHERITED FROM: connective tissue || bone tissue || skeletal tissue |
Intermediate filament protein, coiled coil region | 0.4135 | INHERITED FROM: optic nerve || spinal ganglion || epidermis || epithelium || regenerating tissue || blastema || retinal inner nuclear layer || ganglion || retinal inner plexiform layer || cephalic nerve || retinal ganglion cell || nerve || retinal ganglion cell layer |
Cystine-knot cytokines | 0.4371 | INHERITED FROM: ventral mesoderm || secondary heart field || involuting marginal zone mesenchymal layer || head mesenchyme || involuted dorsal mesoderm || regenerating tissue || blastema || notochord || vegetal endoderm || primary heart field || endoderm || neural groove || neuroectoderm || mesenchyme || mouth primordium || neurogenic placode || mesoderm || head mesoderm |
PGBD-like | 0.4628 | INHERITED FROM: notochord || notochordal sheath |
lambda repressor-like DNA-binding domains | 0.5099 | INHERITED FROM: early distal tubule || neural plate || cranial placode || pronephric mesenchyme || neural fold || chordal neural plate || proximal tubule || distal tubule || pronephric tubule || neuroectoderm || neurogenic placode || late distal tubule |
Kringle-like | 0.5697 | INHERITED FROM: epithelium || neural groove |
FnI-like domain | 0.5777 | INHERITED FROM: epithelial cell || hypochord || somite || notochord || endoderm |
Globin-like | 0.6385 | INHERITED FROM: anterior dorsal lateral plate region || hematopoietic stem cell || ventral blood island || anterior ventral blood island |
Growth factor receptor domain | 0.655 | INHERITED FROM: otic vesicle || tail tip || hypochord || pre-chordal neural plate border || notochord || mesenchyme || fin || anterior neural ridge |
TIMP-like | 0.6949 | INHERITED FROM: stomodeal-hypophyseal primordium || optic field || pre-chordal neural plate || endoderm |
Snake toxin-like | 0.698 | INHERITED FROM: ventral mesoderm || neural plate || pre-chordal neural plate || head mesenchyme || involuted dorsal mesoderm || chordal neural plate || neuroectoderm || mesenchyme || mesoderm || head mesoderm || lateral plate mesoderm |
Kazal-type serine protease inhibitors | 0.7218 | INHERITED FROM: neural plate || hypochord || notochord || neural groove |
Sema domain | 0.7637 | INHERITED FROM: cranial placode || involuted dorsal mesoderm || cranial neural crest || otic placode || neuroectoderm || neural crest |
Protein kinase-like (PK-like) | 0.773 | INHERITED FROM: regenerating hindlimb || head mesoderm |
Integrin domains | 0.831 | INHERITED FROM: mesodermal cell || fibroblast |
EGF/Laminin | 0.8315 | INHERITED FROM: hypochord || notochord || neural groove |
Tropomyosin | 0.8591 | INHERITED FROM: myocardium || myocyte || dermomyotome || myotome |
PYP-like sensor domain (PAS domain) | 0.9786 | INHERITED FROM: epaxial muscle || somite || mesoderm |
Voltage-gated potassium channels | 1 | INHERITED FROM: optic nerve || retinal inner plexiform layer || cephalic nerve || nerve || retinal ganglion cell layer |
TSP-1 type 1 repeat | 1 | INHERITED FROM: hypochord |
Fibronectin type III | 1 | INHERITED FROM: retinal inner nuclear layer || retinal ganglion cell layer |
EF-hand | 1 | INHERITED FROM: myocyte |
Ras GEF | 1 | INHERITED FROM: retinal inner plexiform layer || retinal outer plexiform layer |
Metalloproteases ("zincins"), catalytic domain | 1 | INHERITED FROM: mesodermal cell || notochordal sheath || fibroblast |
Family A G protein-coupled receptor-like | 1 | INHERITED FROM: granule cell layer of the olfactory bulb |
beta-beta-alpha zinc fingers | 1 | INHERITED FROM: pre-chordal neural plate || chordal neural plate border || splanchnic layer of lateral plate mesoderm || neural fold || chordal neural plate || pre-chordal neural plate border || anterior neural ridge |
Plexin repeat | 1 | INHERITED FROM: cranial placode || involuted dorsal mesoderm || cranial neural crest || otic placode || neuroectoderm || neural crest |
Cadherin-like | 1 | INHERITED FROM: neural crest |
SCOP term | FDR (all) | Annotation (direct or inherited) |
alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
Nucleoplasmin-like core domain | 0 | Direct |
SAP domain | 0 | Direct |
Cap-Gly domain | 0 | Direct |
Aconitase iron-sulfur domain | 0 | Direct |
Sec63 N-terminal domain-like | 0 | Direct |
Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
C-terminal domain of adenylylcyclase associated protein | 0 | Direct |
Translation proteins SH3-like domain | 0 | Direct |
PAH2 domain | 0 | Direct |
Succinyl-CoA synthetase domains | 0 | Direct |
DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
RBP11-like subunits of RNA polymerase | 0 | Direct |
Sialidases | 0 | Direct |
L-aspartase-like | 0 | Direct |
Synuclein | 0 | Direct |
beta-sandwich domain of Sec23/24 | 0 | Direct |
KA1-like | 0 | Direct |
GFP-like | 0 | Direct |
Mitochondrial cytochrome c oxidase subunit VIIa | 0 | Direct |
Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
E2F-DP heterodimerization region | 0 | Direct |
Troponin coil-coiled subunits | 0 | Direct |
F1F0 ATP synthase subunit C | 0 | Direct |
4Fe-4S ferredoxins | 0 | Direct |
Helical domain of Sec23/24 | 0 | Direct |
Tim10-like | 0 | Direct |
Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
BRK domain-like | 0 | Direct |
Clathrin adaptor appendage domain | 0 | Direct |
HSP40/DnaJ peptide-binding domain | 0 | Direct |
Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
Orange domain-like | 0 | Direct |
Moesin tail domain | 0 | Direct |
NTF2-like | 0 | Direct |
Fibrinogen coiled-coil and central regions | 0 | Direct |
post-AAA+ oligomerization domain-like | 0 | Direct |
Domain of poly(ADP-ribose) polymerase | 0 | Direct |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
Mediator hinge subcomplex-like | 0 | Direct |
Nucleoporin domain | 0 | Direct |
Cation efflux protein cytoplasmic domain-like | 0 | Direct |
NAP-like | 0 | Direct |
LeuD/IlvD-like | 0 | Direct |
Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
GINS helical bundle-like | 0 | Direct |
Arginase/deacetylase | 0 | Direct |
Phosphoglucomutase, C-terminal domain | 0 | Direct |
HSP90 C-terminal domain | 0 | Direct |
Endosomal sorting complex assembly domain | 0 | Direct |
Mib/herc2 domain-like | 0 | Direct |
N-acetylmuramoyl-L-alanine amidase-like | 0 | Direct |
CoA-dependent acyltransferases | 0 | Direct |
PriA/YqbF domain | 0 | Direct |
alpha-catenin/vinculin-like | 0 | Direct |
DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
Guanido kinase N-terminal domain | 0 | Direct |
Class I glutamine amidotransferase-like | 0 | Direct |
Ribulose-phoshate binding barrel | 0 | Direct |
MIR domain | 0 | Direct |
eIF4e-like | 0 | Direct |
Zn-binding ribosomal proteins | 0 | Direct |
Subunits of heterodimeric actin filament capping protein Capz | 0 | Direct |
Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
Trefoil | 0 | Direct |
BAG domain | 0 | Direct |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
Alpha-macroglobulin receptor domain | 0 | Direct |
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
FAS1 domain | 0 | Direct |
Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
Ribonuclease PH domain 2-like | 0 | Direct |
Proteasome activator | 0 | Direct |
PAP/OAS1 substrate-binding domain | 0 | Direct |
PLP-binding barrel | 0 | Direct |
Apolipoprotein A-I | 0 | Direct |
Surp module (SWAP domain) | 0 | Direct |
Phosphoglucomutase, first 3 domains | 0 | Direct |
FF domain | 0 | Direct |
WGR domain-like | 0 | Direct |
SPOC domain-like | 0 | Direct |
TSP type-3 repeat | 0 | Direct |
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
Connexin43 | 0 | Direct |
HRDC-like | 0 | Direct |
SIS domain | 0 | Direct |
Ferritin-like | 0 | Direct |
Soluble quinoprotein glucose dehydrogenase | 0 | Direct |
Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
TK C-terminal domain-like | 0 | Direct |
SMAD MH1 domain | 0 | Direct |
Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | Direct |
BSD domain-like | 0 | Direct |
G protein-binding domain | 0 | Direct |
Uracil-DNA glycosylase-like | 0 | Direct |
GYF domain | 0 | Direct |
Hedgehog/DD-peptidase | 0 | Direct |
ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
TAFH domain-like | 0 | Direct |
Zn-finger domain of Sec23/24 | 0 | Direct |
Alanine racemase C-terminal domain-like | 0 | Direct |
ADP-ribosylglycohydrolase | 0 | Direct |
DLC | 0 | Direct |
Nop domain | 0 | Direct |
Notch domain | 0 | Direct |
Ribosomal proteins L15p and L18e | 0 | Direct |
LuxS/MPP-like metallohydrolase | 0 | Direct |
Ribosomal protein L10-like | 0 | Direct |
Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
SRF-like | 0 | Direct |
Bromodomain | 0 | Direct |
Cytokine | 0 | Direct |
Acyl-CoA binding protein | 0 | Direct |
FMT C-terminal domain-like | 0 | Direct |
Ribosomal L27 protein-like | 0 | Direct |
Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
Di-copper centre-containing domain | 0 | Direct |
14-3-3 protein | 0 | Direct |
PEBP-like | 0 | Direct |
RNA-binding domain, RBD | 0.000004542 | Direct |
Homeodomain-like | 0.00001111 | Direct |
"Winged helix" DNA-binding domain | 0.00004771 | Direct |
Nucleic acid-binding proteins | 0.0002581 | Direct |
HLH, helix-loop-helix DNA-binding domain | 0.0003919 | Direct |
UBC-like | 0.01607 | Inherited |
Thioredoxin-like | 0.02091 | Inherited |
Cyclin-like | 0.02537 | Inherited |
SET domain | 0.03878 | Inherited |
Actin depolymerizing proteins | 0.05426 | Inherited |
HSP20-like chaperones | 0.0589 | Inherited |
HMG-box | 0.06139 | Inherited |
ARID-like | 0.1027 | Inherited |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0.1027 | Inherited |
Glucocorticoid receptor-like (DNA-binding domain) | 0.1149 | Inherited |
GroEL equatorial domain-like | 0.1235 | Inherited |
Actin-like ATPase domain | 0.1279 | Inherited |
p53-like transcription factors | 0.1348 | Inherited |
Tubulin C-terminal domain-like | 0.1385 | Inherited |
Thiolase-like | 0.1655 | Inherited |
GroEL-intermediate domain like | 0.1655 | Inherited |
Transducin (alpha subunit), insertion domain | 0.2407 | Inherited |
Spectrin repeat | 0.2409 | Inherited |
Tubulin nucleotide-binding domain-like | 0.2599 | Inherited |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.2659 | Inherited |
Hemopexin-like domain | 0.3017 | Inherited |
GroEL apical domain-like | 0.3252 | Inherited |
Myosin rod fragments | 0.35 | Inherited |
SMAD/FHA domain | 0.355 | Inherited |
Frizzled cysteine-rich domain | 0.3607 | Inherited |
Clavaminate synthase-like | 0.3776 | Inherited |
Phosphoglycerate mutase-like | 0.3823 | Inherited |
Annexin | 0.4029 | Inherited |
LDH C-terminal domain-like | 0.4084 | Inherited |
Intermediate filament protein, coiled coil region | 0.4135 | Inherited |
Cystine-knot cytokines | 0.4371 | Inherited |
PGBD-like | 0.4628 | Inherited |
lambda repressor-like DNA-binding domains | 0.5099 | Inherited |
Kringle-like | 0.5697 | Inherited |
FnI-like domain | 0.5777 | Inherited |
Globin-like | 0.6385 | Inherited |
Growth factor receptor domain | 0.655 | Inherited |
TIMP-like | 0.6949 | Inherited |
Snake toxin-like | 0.698 | Inherited |
Kazal-type serine protease inhibitors | 0.7218 | Inherited |
Sema domain | 0.7637 | Inherited |
Protein kinase-like (PK-like) | 0.773 | Inherited |
Integrin domains | 0.831 | Inherited |
EGF/Laminin | 0.8315 | Inherited |
Tropomyosin | 0.8591 | Inherited |
PYP-like sensor domain (PAS domain) | 0.9786 | Inherited |
Voltage-gated potassium channels | 1 | Inherited |
TSP-1 type 1 repeat | 1 | Inherited |
Fibronectin type III | 1 | Inherited |
EF-hand | 1 | Inherited |
Ras GEF | 1 | Inherited |
Metalloproteases ("zincins"), catalytic domain | 1 | Inherited |
Family A G protein-coupled receptor-like | 1 | Inherited |
beta-beta-alpha zinc fingers | 1 | Inherited |
Plexin repeat | 1 | Inherited |
Cadherin-like | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this XA term (SDXA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Translation initiation factor eIF4e | 0 | DIRECT |
Hedgehog (development protein), N-terminal signaling domain | 0 | DIRECT |
Ferritin | 0 | DIRECT |
Trunk domain of Sec23/24 | 0 | DIRECT |
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | DIRECT |
IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
Aminoacid dehydrogenase-like, C-terminal domain | 0 | DIRECT |
MIR domain | 0 | DIRECT |
Alpha-macroglobulin receptor domain | 0 | DIRECT |
LeuD-like | 0 | DIRECT |
MIF4G domain-like | 0 | DIRECT |
Pumilio repeat | 0 | DIRECT |
RNA-polymerase beta | 0 | DIRECT |
Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
Complement components | 0 | DIRECT |
ets domain | 0 | DIRECT |
Mib/herc2 domain | 0 | DIRECT |
NTF2-like | 0 | DIRECT |
Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | DIRECT |
Adenain-like | 0 | DIRECT |
SMAD MH1 domain | 0 | DIRECT |
ADP-ribosylglycohydrolase | 0 | DIRECT |
Phosphatidylethanolamine binding protein | 0 | DIRECT |
FAS1 domain | 0 | DIRECT |
E2F dimerization segment | 0 | DIRECT |
Class I aldolase | 0 | DIRECT |
HD domain | 0 | DIRECT |
Arginase-like amidino hydrolases | 0 | DIRECT |
Cytochrome b5 | 0 | DIRECT |
Thrombospondin C-terminal domain | 0 | DIRECT |
SAP domain | 0 | DIRECT |
TAFH domain-like | 0 | DIRECT |
Cell cycle transcription factor e2f-dp | 0 | DIRECT |
HCDH C-domain-like | 0 | DIRECT |
14-3-3 protein | 0 | DIRECT |
HAT/Suf repeat | 0 | DIRECT |
RUNT domain | 0 | DIRECT |
NagB-like | 0 | DIRECT |
DNA polymerase III clamp loader subunits, C-terminal domain | 0 | DIRECT |
Proteasome activator | 0 | DIRECT |
Prefoldin | 0 | DIRECT |
gamma-adaptin C-terminal appendage domain-like | 0 | DIRECT |
Guanido kinase catalytic domain | 0 | DIRECT |
Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
F1F0 ATP synthase subunit C | 0 | DIRECT |
Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
Histone deacetylase, HDAC | 0 | DIRECT |
TRASH domain | 0 | DIRECT |
Helical domain of Sec23/24 | 0 | DIRECT |
NIPSNAP | 0 | DIRECT |
DNA ligase | 0 | DIRECT |
Zn-finger domain of Sec23/24 | 0 | DIRECT |
Paired domain | 0 | DIRECT |
Pointed domain | 0 | DIRECT |
Extracellular domain of cell surface receptors | 0 | DIRECT |
Phenylalanine metabolism regulatory domain | 0 | DIRECT |
MPP-like | 0 | DIRECT |
Autophagin-like | 0 | DIRECT |
Alpha-adaptin ear subdomain-like | 0 | DIRECT |
IF2B-like | 0 | DIRECT |
SRF-like | 0 | DIRECT |
Notch domain | 0 | DIRECT |
Acyl-CoA binding protein | 0 | DIRECT |
Aconitase iron-sulfur domain | 0 | DIRECT |
SIAH, seven in absentia homolog | 0 | DIRECT |
GABARAP-like | 0 | DIRECT |
Trefoil | 0 | DIRECT |
Sedlin (SEDL) | 0 | DIRECT |
RNA-polymerase beta-prime | 0 | DIRECT |
PDI-like | 0 | DIRECT |
DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | DIRECT |
LON domain-like | 0 | DIRECT |
ATP-dependent DNA ligase catalytic domain | 0 | DIRECT |
Guanido kinase N-terminal domain | 0 | DIRECT |
MSP-like | 0 | DIRECT |
DLC | 0 | DIRECT |
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
Phosphoglucomutase, first 3 domains | 0 | DIRECT |
Nucleoplasmin-like core domain | 0 | DIRECT |
Alanine racemase-like, N-terminal domain | 0 | DIRECT |
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | DIRECT |
Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
Class II glutamine amidotransferases | 0 | DIRECT |
SMAD domain | 0 | DIRECT |
N-type ATP pyrophosphatases | 0 | DIRECT |
Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | DIRECT |
C-terminal domain of adenylylcyclase associated protein | 0 | DIRECT |
Arrestin/Vps26-like | 0 | DIRECT |
Choline/Carnitine O-acyltransferase | 0 | DIRECT |
beta-sandwich domain of Sec23/24 | 0 | DIRECT |
ZZ domain | 0 | DIRECT |
Branched-chain alpha-keto acid dehydrogenase PP module | 0 | DIRECT |
Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
WGR domain | 0 | DIRECT |
BRK domain-like | 0 | DIRECT |
Moesin tail domain | 0 | DIRECT |
CAT-like | 0 | DIRECT |
Apolipoprotein A-I | 0 | DIRECT |
Noggin | 0 | DIRECT |
Eukaryotic ODC-like | 0 | DIRECT |
HIT (HINT, histidine triad) family of protein kinase-interacting proteins | 0 | DIRECT |
Hairy Orange domain | 0 | DIRECT |
Tim10/DDP | 0 | DIRECT |
HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
HSP90 C-terminal domain | 0 | DIRECT |
NAP-like | 0 | DIRECT |
Cap-Gly domain | 0 | DIRECT |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
Bromodomain | 0 | DIRECT |
Ribosomal proteins L15p and L18e | 0 | DIRECT |
Sm motif of small nuclear ribonucleoproteins, SNRNP | 0 | DIRECT |
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | DIRECT |
PAH2 domain | 0 | DIRECT |
alpha-catenin/vinculin | 0 | DIRECT |
Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
Heat-shock transcription factor | 0 | DIRECT |
A20-like zinc finger | 0 | DIRECT |
Domain G2 of nidogen-1 | 0 | DIRECT |
Carboxylesterase | 0 | DIRECT |
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | DIRECT |
ECR1 N-terminal domain-like | 0 | DIRECT |
alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | DIRECT |
BAG domain | 0 | DIRECT |
Hsp90 middle domain | 0 | DIRECT |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
P4 origin-binding domain-like | 0 | DIRECT |
Troponin I | 0 | DIRECT |
acyl-CoA oxidase C-terminal domains | 0 | DIRECT |
Retinol binding protein-like | 0 | DIRECT |
Ribonuclease PH domain 1-like | 0 | DIRECT |
Connexin43 | 0 | DIRECT |
UBX domain | 0 | DIRECT |
L domain | 0 | DIRECT |
Fibrinogen coiled-coil and central regions | 0 | DIRECT |
Pseudouridine synthase I TruA | 0 | DIRECT |
Mitochondrial cytochrome c oxidase subunit VIIa | 0 | DIRECT |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
Ribosomal protein L3 | 0 | DIRECT |
MHCK/EF2 kinase | 0 | DIRECT |
BSD domain | 0 | DIRECT |
Malic enzyme N-domain | 0 | DIRECT |
TRAPP components | 0 | DIRECT |
Phosphoribosylpyrophosphate synthetase-like | 0 | DIRECT |
Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
Ribonuclease PH domain 2-like | 0 | DIRECT |
Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
N-acetylmuramoyl-L-alanine amidase-like | 0 | DIRECT |
Ran-binding domain | 0 | DIRECT |
S-adenosylhomocystein hydrolase | 0 | DIRECT |
DJ-1/PfpI | 0 | DIRECT |
Noncollagenous (NC1) domain of collagen IV | 0 | DIRECT |
Kinase associated domain 1, KA1 | 0 | DIRECT |
Nop domain | 0 | DIRECT |
Fibroblast growth factors (FGF) | 0 | DIRECT |
SH3BGR (SH3-binding, glutamic acid-rich protein-like) | 0 | DIRECT |
Synuclein | 0 | DIRECT |
Cytidylyltransferase | 0 | DIRECT |
TSP type-3 repeat | 0 | DIRECT |
Prokaryotic proteases | 0 | DIRECT |
Troponin T | 0 | DIRECT |
Surp module (SWAP domain) | 0 | DIRECT |
Polo-box duplicated region | 0 | DIRECT |
NLI interacting factor-like phosphatase | 0 | DIRECT |
Cystathionine synthase-like | 0 | DIRECT |
Serine carboxypeptidase-like | 0 | DIRECT |
Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | DIRECT |
DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
Succinyl-CoA synthetase domains | 0 | DIRECT |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
GDI-like N domain | 0 | DIRECT |
Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | DIRECT |
B56-like | 0 | DIRECT |
acyl-CoA oxidase N-terminal domains | 0 | DIRECT |
Cofilin-like | 0 | DIRECT |
FF domain | 0 | DIRECT |
Canonical RBD | 0.000000305 | DIRECT |
Homeodomain | 0.0002637 | DIRECT |
UBC-related | 0.0004594 | DIRECT |
HLH, helix-loop-helix DNA-binding domain | 0.0006991 | DIRECT |
Cyclin | 0.009923 | INHERITED FROM: postmigratory neural crest cell || migratory neural crest cell |
Actin/HSP70 | 0.01593 | INHERITED FROM: skeletal muscle || jaw muscle || trunk somite || myocyte || muscle || cranial muscle || head somite || head mesoderm |
Forkhead DNA-binding domain | 0.01624 | INHERITED FROM: optic field || epithelial cell || tail tip || vagal neural crest || chordoneural hinge || neural plate || pre-chordal neural plate || ciliated epidermal cell || preplacodal ectoderm || involuted dorsal mesoderm || neural fold || pre-chordal neural plate border || presomitic mesoderm || anterior neural fold || tail fin || myocardium || neuroectoderm || mesenchyme || mesoderm || sensorial layer of neurectoderm || neural crest || head mesoderm || involuted ventral mesoderm || anterior placodal area || pronephric nephrostome || anterior neural ridge |
Histone lysine methyltransferases | 0.02852 | INHERITED FROM: primary germ layer |
Proteasome subunits | 0.02852 | INHERITED FROM: skeletal muscle || muscle |
Tandem AAA-ATPase domain | 0.03862 | INHERITED FROM: otic vesicle || ventral blood island |
LIM domain | 0.04299 | INHERITED FROM: cranial placode |
T-box | 0.04781 | INHERITED FROM: involuted dorsal mesoderm || regenerating tissue || blastema || notochord || primary heart field || myocardium || mesenchyme || neurogenic placode || mesoderm || involuted ventral mesoderm |
Glutathione peroxidase-like | 0.0521 | INHERITED FROM: early proximal tubule || early distal tubule || pronephric mesenchyme || paraxial mesoderm || proximal tubule || presomitic mesoderm || bone tissue || distal tubule || pronephric tubule || cranial neural crest || skeletal tissue || presumptive paraxial mesoderm |
PHD domain | 0.06342 | INHERITED FROM: primary germ layer |
HMG-box | 0.07126 | INHERITED FROM: optic field || retinal layer || otic vesicle || endocardium || neural plate || neural plate border || pre-chordal neural plate || neural fold || neuroectoderm outer layer || midbrain-hindbrain boundary || anterior branchial crest || anterior neural fold || endoderm || blastocoel floor || cranial neural crest || posterior branchial crest || neuroectoderm || mandibular crest || neurogenic placode || hyoid crest |
Transforming growth factor (TGF)-beta | 0.07301 | INHERITED FROM: ventral mesoderm || secondary heart field || gastrocoel roof plate || early distal tubule || involuting marginal zone mesenchymal layer || head mesenchyme || involuted dorsal mesoderm || regenerating tissue || blastema || notochord || vegetal endoderm || primary heart field || endoderm || mesenchyme || mouth primordium || neurogenic placode || mesoderm || head mesoderm |
ARID domain | 0.101 | INHERITED FROM: pronephric tubule |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0.101 | INHERITED FROM: skeletal muscle |
Growth factor receptor domain | 0.1265 | INHERITED FROM: hypochord || notochord || mesenchyme || fin || mesoderm |
Tubulin, GTPase domain | 0.1445 | INHERITED FROM: epidermis || epithelial cell || gastrocoel roof plate || epithelium || trigeminal nerve || facial nerve || vagus nerve || epidermal cell || glossopharyngeal nerve || non-neural ectoderm |
Tubulin, C-terminal domain | 0.1445 | INHERITED FROM: epidermis || epithelial cell || gastrocoel roof plate || epithelium || trigeminal nerve || facial nerve || vagus nerve || epidermal cell || glossopharyngeal nerve || non-neural ectoderm |
Small Kunitz-type inhibitors & BPTI-like toxins | 0.1579 | INHERITED FROM: adipose tissue |
Thiolase-related | 0.2059 | INHERITED FROM: skeletal muscle || muscle |
Group II chaperonin (CCT, TRIC), apical domain | 0.2059 | INHERITED FROM: skeletal muscle || anterior dorsal lateral plate region || muscle |
Translational machinery components | 0.2059 | INHERITED FROM: skeletal muscle || muscle |
Group II chaperonin (CCT, TRIC), ATPase domain | 0.207 | INHERITED FROM: skeletal muscle || muscle |
Myosin rod fragments | 0.2108 | INHERITED FROM: musculature of face |
Transducin (alpha subunit), insertion domain | 0.2435 | INHERITED FROM: olfactory epithelium || olfactory sensory neuron |
POU-specific domain | 0.2435 | INHERITED FROM: early distal tubule || neural plate || pre-chordal neural plate || pronephric mesenchyme || neural fold || chordal neural plate || proximal tubule || distal tubule || pronephric tubule || neuroectoderm || neurogenic placode || late distal tubule || retinal ganglion cell layer |
Erythroid transcription factor GATA-1 | 0.2575 | INHERITED FROM: anterior dorsal lateral plate region || hematopoietic stem cell || endoderm || myocardium || archenteron || ventral blood island || mesoderm || archenteron floor || lateral plate mesoderm |
Ovomucoid domain III-like | 0.2673 | INHERITED FROM: neural plate || hypochord || notochord || neural groove |
Second domain of FERM | 0.2718 | INHERITED FROM: trigeminal nerve |
Hemopexin-like domain | 0.3138 | INHERITED FROM: notochord || mesodermal cell || fibroblast |
Parvalbumin | 0.3221 | INHERITED FROM: somite || cranial muscle |
Cell cycle control phosphatase, catalytic domain | 0.3221 | INHERITED FROM: neural plate || chordal neural plate || neuroectoderm |
Higher-molecular-weight phosphotyrosine protein phosphatases | 0.3271 | INHERITED FROM: retinal inner nuclear layer || retinal ganglion cell layer |
I set domains | 0.3395 | INHERITED FROM: retinal inner nuclear layer || regenerating hindlimb || pharyngeal mesenchyme || wound epidermis || retinal ganglion cell layer |
VWC domain | 0.3436 | INHERITED FROM: hypochord || notochord || endoderm || mesenchyme || mesoderm |
Frizzled cysteine-rich domain | 0.3733 | INHERITED FROM: stomodeal-hypophyseal primordium || optic field || otic vesicle || tail tip || neural plate || pre-chordal neural plate || involuted dorsal mesoderm || neural fold || somite || presomitic mesoderm || midbrain-hindbrain boundary || anterior neural fold || tail fin || endoderm || neuroectoderm || mesenchyme || mouth primordium || mesoderm || lateral plate mesoderm || presumptive paraxial mesoderm |
Spectrin repeat | 0.3733 | INHERITED FROM: epithelial cell || sensory epithelial cell || auditory hair cell |
LDH N-terminal domain-like | 0.399 | INHERITED FROM: connective tissue || bone tissue || skeletal tissue |
Linker histone H1/H5 | 0.399 | INHERITED FROM: connective tissue || bone tissue || skeletal tissue |
Lactate & malate dehydrogenases, C-terminal domain | 0.399 | INHERITED FROM: connective tissue || bone tissue || skeletal tissue |
Matrix metalloproteases, catalytic domain | 0.4134 | INHERITED FROM: notochord || mesodermal cell || notochordal sheath || fibroblast |
Intermediate filament protein, coiled coil region | 0.4446 | INHERITED FROM: optic nerve || spinal ganglion || epidermis || epithelium || regenerating tissue || blastema || retinal inner nuclear layer || ganglion || vestibulocochlear nerve || retinal inner plexiform layer || cephalic nerve || retinal ganglion cell || nerve || retinal ganglion cell layer |
MMP N-terminal domain | 0.4736 | INHERITED FROM: notochord || notochordal sheath |
Sema domain | 0.5392 | INHERITED FROM: neural plate || cranial placode || involuted dorsal mesoderm || midbrain-hindbrain boundary || cranial neural crest || otic placode || neuroectoderm || neural crest |
G proteins | 0.5643 | INHERITED FROM: olfactory epithelium || olfactory sensory neuron |
Fibronectin type II module | 0.6306 | INHERITED FROM: epithelium || mesenchyme |
Globins | 0.6382 | INHERITED FROM: anterior dorsal lateral plate region || hematopoietic stem cell || ventral blood island || anterior ventral blood island |
Kringle modules | 0.6664 | INHERITED FROM: neural groove |
Tropomyosin | 0.7011 | INHERITED FROM: myocardium || myocyte || dermomyotome || myotome || multilaminar epithelium |
Multidrug efflux transporter AcrB transmembrane domain | 0.7201 | INHERITED FROM: epidermis |
Ephrin ectodomain | 0.7201 | INHERITED FROM: sensorial layer of neurectoderm |
Arginine methyltransferase | 0.7201 | INHERITED FROM: cranial neural crest |
Hypoxia-inducible factor Hif2a, C-terminal domain | 0.8233 | INHERITED FROM: epaxial muscle || otic vesicle || somite || pronephric tubule || mesoderm |
Integrin domains | 0.8385 | INHERITED FROM: mesodermal cell || fibroblast |
Ephrin receptor ligand binding domain | 0.8521 | INHERITED FROM: branchial crest |
28-residue LRR | 0.8798 | INHERITED FROM: epaxial muscle |
Proprotein convertase P-domain | 0.9202 | INHERITED FROM: notochord |
Motor proteins | 0.9556 | INHERITED FROM: musculature of face |
Protein kinases, catalytic subunit | 0.9897 | INHERITED FROM: regenerating hindlimb || head mesoderm |
TSP-1 type 1 repeat | 1 | INHERITED FROM: hypochord |
Calmodulin-like | 1 | INHERITED FROM: epithelial cell || ciliated epidermal cell |
Fibronectin type III | 1 | INHERITED FROM: retinal ganglion cell layer |
Rhodopsin-like | 1 | INHERITED FROM: granule cell layer of the olfactory bulb || eye photoreceptor cell |
Voltage-gated potassium channels | 1 | INHERITED FROM: optic nerve || retinal inner plexiform layer |
Classic zinc finger, C2H2 | 1 | INHERITED FROM: neural plate border || pre-chordal neural plate || chordal neural plate border || splanchnic layer of lateral plate mesoderm || neural fold || chordal neural plate || pre-chordal neural plate border || anterior neural fold || anterior neural ridge |
Plexin repeat | 1 | INHERITED FROM: cranial placode || cranial neural crest || otic placode || neuroectoderm || neural crest |
Tetramerization domain of potassium channels | 1 | INHERITED FROM: optic nerve || retinal inner plexiform layer || retinal ganglion cell layer || retinal outer plexiform layer |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Translation initiation factor eIF4e | 0 | Direct |
Hedgehog (development protein), N-terminal signaling domain | 0 | Direct |
Ferritin | 0 | Direct |
Trunk domain of Sec23/24 | 0 | Direct |
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | Direct |
IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
Aminoacid dehydrogenase-like, C-terminal domain | 0 | Direct |
MIR domain | 0 | Direct |
Alpha-macroglobulin receptor domain | 0 | Direct |
LeuD-like | 0 | Direct |
MIF4G domain-like | 0 | Direct |
Pumilio repeat | 0 | Direct |
RNA-polymerase beta | 0 | Direct |
Phosphoglucomutase, C-terminal domain | 0 | Direct |
Complement components | 0 | Direct |
ets domain | 0 | Direct |
Mib/herc2 domain | 0 | Direct |
NTF2-like | 0 | Direct |
Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | Direct |
Adenain-like | 0 | Direct |
SMAD MH1 domain | 0 | Direct |
ADP-ribosylglycohydrolase | 0 | Direct |
Phosphatidylethanolamine binding protein | 0 | Direct |
FAS1 domain | 0 | Direct |
E2F dimerization segment | 0 | Direct |
Class I aldolase | 0 | Direct |
HD domain | 0 | Direct |
Arginase-like amidino hydrolases | 0 | Direct |
Cytochrome b5 | 0 | Direct |
Thrombospondin C-terminal domain | 0 | Direct |
SAP domain | 0 | Direct |
TAFH domain-like | 0 | Direct |
Cell cycle transcription factor e2f-dp | 0 | Direct |
HCDH C-domain-like | 0 | Direct |
14-3-3 protein | 0 | Direct |
HAT/Suf repeat | 0 | Direct |
RUNT domain | 0 | Direct |
NagB-like | 0 | Direct |
DNA polymerase III clamp loader subunits, C-terminal domain | 0 | Direct |
Proteasome activator | 0 | Direct |
Prefoldin | 0 | Direct |
gamma-adaptin C-terminal appendage domain-like | 0 | Direct |
Guanido kinase catalytic domain | 0 | Direct |
Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
F1F0 ATP synthase subunit C | 0 | Direct |
Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
Histone deacetylase, HDAC | 0 | Direct |
TRASH domain | 0 | Direct |
Helical domain of Sec23/24 | 0 | Direct |
NIPSNAP | 0 | Direct |
DNA ligase | 0 | Direct |
Zn-finger domain of Sec23/24 | 0 | Direct |
Paired domain | 0 | Direct |
Pointed domain | 0 | Direct |
Extracellular domain of cell surface receptors | 0 | Direct |
Phenylalanine metabolism regulatory domain | 0 | Direct |
MPP-like | 0 | Direct |
Autophagin-like | 0 | Direct |
Alpha-adaptin ear subdomain-like | 0 | Direct |
IF2B-like | 0 | Direct |
SRF-like | 0 | Direct |
Notch domain | 0 | Direct |
Acyl-CoA binding protein | 0 | Direct |
Aconitase iron-sulfur domain | 0 | Direct |
SIAH, seven in absentia homolog | 0 | Direct |
GABARAP-like | 0 | Direct |
Trefoil | 0 | Direct |
Sedlin (SEDL) | 0 | Direct |
RNA-polymerase beta-prime | 0 | Direct |
PDI-like | 0 | Direct |
DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | Direct |
LON domain-like | 0 | Direct |
ATP-dependent DNA ligase catalytic domain | 0 | Direct |
Guanido kinase N-terminal domain | 0 | Direct |
MSP-like | 0 | Direct |
DLC | 0 | Direct |
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
Phosphoglucomutase, first 3 domains | 0 | Direct |
Nucleoplasmin-like core domain | 0 | Direct |
Alanine racemase-like, N-terminal domain | 0 | Direct |
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | Direct |
Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
Class II glutamine amidotransferases | 0 | Direct |
SMAD domain | 0 | Direct |
N-type ATP pyrophosphatases | 0 | Direct |
Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | Direct |
C-terminal domain of adenylylcyclase associated protein | 0 | Direct |
Arrestin/Vps26-like | 0 | Direct |
Choline/Carnitine O-acyltransferase | 0 | Direct |
beta-sandwich domain of Sec23/24 | 0 | Direct |
ZZ domain | 0 | Direct |
Branched-chain alpha-keto acid dehydrogenase PP module | 0 | Direct |
Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
WGR domain | 0 | Direct |
BRK domain-like | 0 | Direct |
Moesin tail domain | 0 | Direct |
CAT-like | 0 | Direct |
Apolipoprotein A-I | 0 | Direct |
Noggin | 0 | Direct |
Eukaryotic ODC-like | 0 | Direct |
HIT (HINT, histidine triad) family of protein kinase-interacting proteins | 0 | Direct |
Hairy Orange domain | 0 | Direct |
Tim10/DDP | 0 | Direct |
HSP40/DnaJ peptide-binding domain | 0 | Direct |
HSP90 C-terminal domain | 0 | Direct |
NAP-like | 0 | Direct |
Cap-Gly domain | 0 | Direct |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
Bromodomain | 0 | Direct |
Ribosomal proteins L15p and L18e | 0 | Direct |
Sm motif of small nuclear ribonucleoproteins, SNRNP | 0 | Direct |
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | Direct |
PAH2 domain | 0 | Direct |
alpha-catenin/vinculin | 0 | Direct |
Class I glutamine amidotransferases (GAT) | 0 | Direct |
Heat-shock transcription factor | 0 | Direct |
A20-like zinc finger | 0 | Direct |
Domain G2 of nidogen-1 | 0 | Direct |
Carboxylesterase | 0 | Direct |
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | Direct |
ECR1 N-terminal domain-like | 0 | Direct |
alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | Direct |
BAG domain | 0 | Direct |
Hsp90 middle domain | 0 | Direct |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
P4 origin-binding domain-like | 0 | Direct |
Troponin I | 0 | Direct |
acyl-CoA oxidase C-terminal domains | 0 | Direct |
Retinol binding protein-like | 0 | Direct |
Ribonuclease PH domain 1-like | 0 | Direct |
Connexin43 | 0 | Direct |
UBX domain | 0 | Direct |
L domain | 0 | Direct |
Fibrinogen coiled-coil and central regions | 0 | Direct |
Pseudouridine synthase I TruA | 0 | Direct |
Mitochondrial cytochrome c oxidase subunit VIIa | 0 | Direct |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
Ribosomal protein L3 | 0 | Direct |
MHCK/EF2 kinase | 0 | Direct |
BSD domain | 0 | Direct |
Malic enzyme N-domain | 0 | Direct |
TRAPP components | 0 | Direct |
Phosphoribosylpyrophosphate synthetase-like | 0 | Direct |
Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
Ribonuclease PH domain 2-like | 0 | Direct |
Domain of poly(ADP-ribose) polymerase | 0 | Direct |
N-acetylmuramoyl-L-alanine amidase-like | 0 | Direct |
Ran-binding domain | 0 | Direct |
S-adenosylhomocystein hydrolase | 0 | Direct |
DJ-1/PfpI | 0 | Direct |
Noncollagenous (NC1) domain of collagen IV | 0 | Direct |
Kinase associated domain 1, KA1 | 0 | Direct |
Nop domain | 0 | Direct |
Fibroblast growth factors (FGF) | 0 | Direct |
SH3BGR (SH3-binding, glutamic acid-rich protein-like) | 0 | Direct |
Synuclein | 0 | Direct |
Cytidylyltransferase | 0 | Direct |
TSP type-3 repeat | 0 | Direct |
Prokaryotic proteases | 0 | Direct |
Troponin T | 0 | Direct |
Surp module (SWAP domain) | 0 | Direct |
Polo-box duplicated region | 0 | Direct |
NLI interacting factor-like phosphatase | 0 | Direct |
Cystathionine synthase-like | 0 | Direct |
Serine carboxypeptidase-like | 0 | Direct |
Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | Direct |
DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
Succinyl-CoA synthetase domains | 0 | Direct |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
GDI-like N domain | 0 | Direct |
Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | Direct |
B56-like | 0 | Direct |
acyl-CoA oxidase N-terminal domains | 0 | Direct |
Cofilin-like | 0 | Direct |
FF domain | 0 | Direct |
Canonical RBD | 0.000000305 | Direct |
Homeodomain | 0.0002637 | Direct |
UBC-related | 0.0004594 | Direct |
HLH, helix-loop-helix DNA-binding domain | 0.0006991 | Direct |
Cyclin | 0.009923 | Inherited |
Actin/HSP70 | 0.01593 | Inherited |
Forkhead DNA-binding domain | 0.01624 | Inherited |
Histone lysine methyltransferases | 0.02852 | Inherited |
Proteasome subunits | 0.02852 | Inherited |
Tandem AAA-ATPase domain | 0.03862 | Inherited |
LIM domain | 0.04299 | Inherited |
T-box | 0.04781 | Inherited |
Glutathione peroxidase-like | 0.0521 | Inherited |
PHD domain | 0.06342 | Inherited |
HMG-box | 0.07126 | Inherited |
Transforming growth factor (TGF)-beta | 0.07301 | Inherited |
ARID domain | 0.101 | Inherited |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0.101 | Inherited |
Growth factor receptor domain | 0.1265 | Inherited |
Tubulin, GTPase domain | 0.1445 | Inherited |
Tubulin, C-terminal domain | 0.1445 | Inherited |
Small Kunitz-type inhibitors & BPTI-like toxins | 0.1579 | Inherited |
Thiolase-related | 0.2059 | Inherited |
Group II chaperonin (CCT, TRIC), apical domain | 0.2059 | Inherited |
Translational machinery components | 0.2059 | Inherited |
Group II chaperonin (CCT, TRIC), ATPase domain | 0.207 | Inherited |
Myosin rod fragments | 0.2108 | Inherited |
Transducin (alpha subunit), insertion domain | 0.2435 | Inherited |
POU-specific domain | 0.2435 | Inherited |
Erythroid transcription factor GATA-1 | 0.2575 | Inherited |
Ovomucoid domain III-like | 0.2673 | Inherited |
Second domain of FERM | 0.2718 | Inherited |
Hemopexin-like domain | 0.3138 | Inherited |
Parvalbumin | 0.3221 | Inherited |
Cell cycle control phosphatase, catalytic domain | 0.3221 | Inherited |
Higher-molecular-weight phosphotyrosine protein phosphatases | 0.3271 | Inherited |
I set domains | 0.3395 | Inherited |
VWC domain | 0.3436 | Inherited |
Frizzled cysteine-rich domain | 0.3733 | Inherited |
Spectrin repeat | 0.3733 | Inherited |
LDH N-terminal domain-like | 0.399 | Inherited |
Linker histone H1/H5 | 0.399 | Inherited |
Lactate & malate dehydrogenases, C-terminal domain | 0.399 | Inherited |
Matrix metalloproteases, catalytic domain | 0.4134 | Inherited |
Intermediate filament protein, coiled coil region | 0.4446 | Inherited |
MMP N-terminal domain | 0.4736 | Inherited |
Sema domain | 0.5392 | Inherited |
G proteins | 0.5643 | Inherited |
Fibronectin type II module | 0.6306 | Inherited |
Globins | 0.6382 | Inherited |
Kringle modules | 0.6664 | Inherited |
Tropomyosin | 0.7011 | Inherited |
Multidrug efflux transporter AcrB transmembrane domain | 0.7201 | Inherited |
Ephrin ectodomain | 0.7201 | Inherited |
Arginine methyltransferase | 0.7201 | Inherited |
Hypoxia-inducible factor Hif2a, C-terminal domain | 0.8233 | Inherited |
Integrin domains | 0.8385 | Inherited |
Ephrin receptor ligand binding domain | 0.8521 | Inherited |
28-residue LRR | 0.8798 | Inherited |
Proprotein convertase P-domain | 0.9202 | Inherited |
Motor proteins | 0.9556 | Inherited |
Protein kinases, catalytic subunit | 0.9897 | Inherited |
TSP-1 type 1 repeat | 1 | Inherited |
Calmodulin-like | 1 | Inherited |
Fibronectin type III | 1 | Inherited |
Rhodopsin-like | 1 | Inherited |
Voltage-gated potassium channels | 1 | Inherited |
Classic zinc finger, C2H2 | 1 | Inherited |
Plexin repeat | 1 | Inherited |
Tetramerization domain of potassium channels | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this XA term (SPXA level: Least Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
Endosomal sorting complex assembly domain | 0 | DIRECT |
Zn-binding ribosomal proteins | 0 | DIRECT |
beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
14-3-3 protein | 0 | DIRECT |
TAFH domain-like | 0 | DIRECT |
NTF2-like | 0 | DIRECT |
Acyl-CoA binding protein | 0 | DIRECT |
Hedgehog/DD-peptidase | 0 | DIRECT |
PLP-binding barrel | 0 | DIRECT |
Surp module (SWAP domain) | 0 | DIRECT |
Zn-finger domain of Sec23/24 | 0 | DIRECT |
LuxS/MPP-like metallohydrolase | 0 | DIRECT |
Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
Mitochondrial cytochrome c oxidase subunit VIIa | 0 | DIRECT |
CoA-dependent acyltransferases | 0 | DIRECT |
TSP type-3 repeat | 0 | DIRECT |
Nop domain | 0 | DIRECT |
F1F0 ATP synthase subunit C | 0 | DIRECT |
DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
Mediator hinge subcomplex-like | 0 | DIRECT |
4Fe-4S ferredoxins | 0 | DIRECT |
alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
Synuclein | 0 | DIRECT |
Orange domain-like | 0 | DIRECT |
Sialidases | 0 | DIRECT |
FF domain | 0 | DIRECT |
N-acetylmuramoyl-L-alanine amidase-like | 0 | DIRECT |
PEBP-like | 0 | DIRECT |
SPOC domain-like | 0 | DIRECT |
Helical domain of Sec23/24 | 0 | DIRECT |
Nucleoplasmin-like core domain | 0 | DIRECT |
SAP domain | 0 | DIRECT |
Succinyl-CoA synthetase domains | 0 | DIRECT |
SIS domain | 0 | DIRECT |
Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | DIRECT |
TK C-terminal domain-like | 0 | DIRECT |
Sec63 N-terminal domain-like | 0 | DIRECT |
Connexin43 | 0 | DIRECT |
Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
LeuD/IlvD-like | 0 | DIRECT |
Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
GINS helical bundle-like | 0 | DIRECT |
SMAD MH1 domain | 0 | DIRECT |
GYF domain | 0 | DIRECT |
ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
FMT C-terminal domain-like | 0 | DIRECT |
HSP90 C-terminal domain | 0 | DIRECT |
Moesin tail domain | 0 | DIRECT |
GFP-like | 0 | DIRECT |
E2F-DP heterodimerization region | 0 | DIRECT |
DLC | 0 | DIRECT |
WGR domain-like | 0 | DIRECT |
alpha-catenin/vinculin-like | 0 | DIRECT |
Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
Clathrin adaptor appendage domain | 0 | DIRECT |
L-aspartase-like | 0 | DIRECT |
Class I glutamine amidotransferase-like | 0 | DIRECT |
G protein-binding domain | 0 | DIRECT |
Fibrinogen coiled-coil and central regions | 0 | DIRECT |
Trefoil | 0 | DIRECT |
Apolipoprotein A-I | 0 | DIRECT |
Subunits of heterodimeric actin filament capping protein Capz | 0 | DIRECT |
Uracil-DNA glycosylase-like | 0 | DIRECT |
post-AAA+ oligomerization domain-like | 0 | DIRECT |
Guanido kinase N-terminal domain | 0 | DIRECT |
Soluble quinoprotein glucose dehydrogenase | 0 | DIRECT |
Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
FAS1 domain | 0 | DIRECT |
Alpha-macroglobulin receptor domain | 0 | DIRECT |
Di-copper centre-containing domain | 0 | DIRECT |
BRK domain-like | 0 | DIRECT |
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
Ribosomal L27 protein-like | 0 | DIRECT |
BSD domain-like | 0 | DIRECT |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
SRF-like | 0 | DIRECT |
NAP-like | 0 | DIRECT |
Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
beta-sandwich domain of Sec23/24 | 0 | DIRECT |
Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
Nucleoporin domain | 0 | DIRECT |
BAG domain | 0 | DIRECT |
Ribosomal proteins L15p and L18e | 0 | DIRECT |
KA1-like | 0 | DIRECT |
Bromodomain | 0 | DIRECT |
Ribonuclease PH domain 2-like | 0 | DIRECT |
Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
Proteasome activator | 0 | DIRECT |
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
PAH2 domain | 0 | DIRECT |
Aconitase iron-sulfur domain | 0 | DIRECT |
RBP11-like subunits of RNA polymerase | 0 | DIRECT |
Tim10-like | 0 | DIRECT |
DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
Ribosomal protein L10-like | 0 | DIRECT |
Ferritin-like | 0 | DIRECT |
Mib/herc2 domain-like | 0 | DIRECT |
C-terminal domain of adenylylcyclase associated protein | 0 | DIRECT |
HRDC-like | 0 | DIRECT |
Ribulose-phoshate binding barrel | 0 | DIRECT |
Troponin coil-coiled subunits | 0 | DIRECT |
Translation proteins SH3-like domain | 0 | DIRECT |
ADP-ribosylglycohydrolase | 0 | DIRECT |
Arginase/deacetylase | 0 | DIRECT |
Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
Phosphoglucomutase, first 3 domains | 0 | DIRECT |
Alanine racemase C-terminal domain-like | 0 | DIRECT |
eIF4e-like | 0 | DIRECT |
PriA/YqbF domain | 0 | DIRECT |
Notch domain | 0 | DIRECT |
Cytokine | 0 | DIRECT |
Cap-Gly domain | 0 | DIRECT |
Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
MIR domain | 0 | DIRECT |
PAP/OAS1 substrate-binding domain | 0 | DIRECT |
RNA-binding domain, RBD | 0.000003256 | DIRECT |
Homeodomain-like | 0.000008008 | DIRECT |
"Winged helix" DNA-binding domain | 0.00003491 | DIRECT |
Nucleic acid-binding proteins | 0.0001925 | DIRECT |
HLH, helix-loop-helix DNA-binding domain | 0.0002936 | DIRECT |
UBC-like | 0.01269 | INHERITED FROM: skeletal tissue || bone tissue |
Thioredoxin-like | 0.0166 | INHERITED FROM: skeletal tissue || early proximal tubule || connective tissue || bone tissue |
Cyclin-like | 0.02027 | INHERITED FROM: postmigratory neural crest cell |
SET domain | 0.03153 | INHERITED FROM: primary germ layer |
Actin depolymerizing proteins | 0.04465 | INHERITED FROM: skeletal tissue || connective tissue || bone tissue |
HSP20-like chaperones | 0.04862 | INHERITED FROM: skeletal muscle |
HMG-box | 0.05067 | INHERITED FROM: posterior branchial crest || neural plate border || hyoid crest || neural crest || mandibular crest || chordal neural plate || otic vesicle || posterior placodal area || endoderm || neuroectoderm outer layer || midbrain-hindbrain boundary || blastocoel floor || anterior neural fold || neural fold || neurogenic placode || neuroectoderm || neural plate || anterior branchial crest || endocardium || branchial crest || cranial neural crest || pre-chordal neural plate || retinal layer || optic field |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0.08697 | INHERITED FROM: skeletal muscle |
ARID-like | 0.08697 | INHERITED FROM: pronephric tubule |
Glucocorticoid receptor-like (DNA-binding domain) | 0.09797 | INHERITED FROM: preplacodal ectoderm || sensorial layer of neurectoderm || zona limitans intrathalamica || anterior placodal area || archenteron floor || cranial placode || neuroectoderm || post-anal gut || proximal tubule branch |
GroEL equatorial domain-like | 0.1061 | INHERITED FROM: skeletal muscle || anterior dorsal lateral plate region || muscle || endomesoderm |
Actin-like ATPase domain | 0.1101 | INHERITED FROM: jaw muscle || myocyte || skeletal muscle || cranial muscle || head somite |
p53-like transcription factors | 0.1165 | INHERITED FROM: myocardium || mesoderm || cartilage tissue || primary heart field || involuted ventral mesoderm || blastema || cranial placode || neurogenic placode || neuroectoderm || neural plate || notochord || regenerating tissue || mesenchyme || facial nerve |
Tubulin C-terminal domain-like | 0.1199 | INHERITED FROM: non-neural ectoderm || vagus nerve || epidermal cell || epidermis || epithelium || gastrocoel roof plate || trigeminal nerve || epithelial cell || glossopharyngeal nerve || facial nerve |
BPTI-like | 0.1416 | INHERITED FROM: adipose tissue |
Thiolase-like | 0.1445 | INHERITED FROM: skeletal muscle |
GroEL-intermediate domain like | 0.1445 | INHERITED FROM: skeletal muscle || anterior dorsal lateral plate region || muscle || endomesoderm |
Second domain of FERM | 0.1731 | INHERITED FROM: nerve || cephalic nerve |
Transducin (alpha subunit), insertion domain | 0.215 | INHERITED FROM: olfactory sensory neuron || olfactory epithelium |
Spectrin repeat | 0.2152 | INHERITED FROM: sensory epithelial cell || auditory hair cell || epithelial cell |
Translation proteins | 0.2152 | INHERITED FROM: skeletal muscle || ventral blood island |
Tubulin nucleotide-binding domain-like | 0.2329 | INHERITED FROM: non-neural ectoderm || vagus nerve || epidermal cell || epidermis || epithelium || gastrocoel roof plate || trigeminal nerve || epithelial cell || glossopharyngeal nerve || facial nerve |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.2386 | INHERITED FROM: skeletal muscle |
Hemopexin-like domain | 0.2732 | INHERITED FROM: fibroblast || mesodermal cell || notochord |
GroEL apical domain-like | 0.2956 | INHERITED FROM: skeletal muscle || anterior dorsal lateral plate region || muscle |
Myosin rod fragments | 0.3195 | INHERITED FROM: musculature of face |
SMAD/FHA domain | 0.3243 | INHERITED FROM: endocardium |
Frizzled cysteine-rich domain | 0.3298 | INHERITED FROM: presomitic mesoderm || mesoderm || tail fin || otic vesicle || mouth primordium || endoderm || midbrain-hindbrain boundary || anterior neural fold || lateral plate mesoderm || neural fold || neuroectoderm || tail tip || somite || neural plate || stomodeal-hypophyseal primordium || mesenchyme || involuted dorsal mesoderm || pre-chordal neural plate || cranial ganglion || optic field || presumptive paraxial mesoderm || ganglion |
Clavaminate synthase-like | 0.3462 | INHERITED FROM: early proximal tubule || late proximal tubule || late distal tubule |
Phosphoglycerate mutase-like | 0.3511 | INHERITED FROM: head mesenchyme || notochord || mesenchyme |
Annexin | 0.3716 | INHERITED FROM: skeletal tissue || connective tissue || bone tissue |
LDH C-terminal domain-like | 0.3767 | INHERITED FROM: skeletal tissue || skeletal muscle || connective tissue || bone tissue |
Pentein | 0.3767 | INHERITED FROM: skeletal muscle |
Intermediate filament protein, coiled coil region | 0.3814 | INHERITED FROM: nerve || blastema || optic nerve || vestibulocochlear nerve || retinal ganglion cell layer || epidermis || epithelium || retinal inner plexiform layer || retinal inner nuclear layer || spinal ganglion || regenerating tissue || cephalic nerve || retinal ganglion cell || ganglion |
Cystine-knot cytokines | 0.4034 | INHERITED FROM: involuting marginal zone mesenchymal layer || vegetal endoderm || mesoderm || mouth primordium || primary heart field || endoderm || blastema || neurogenic placode || neuroectoderm || head mesenchyme || notochord || regenerating tissue || mesenchyme || neural groove || involuted dorsal mesoderm || head mesoderm || secondary heart field || ventral mesoderm |
PGBD-like | 0.4288 | INHERITED FROM: notochord || notochordal sheath |
lambda repressor-like DNA-binding domains | 0.4752 | INHERITED FROM: proximal tubule || pronephric tubule || chordal neural plate || pronephric mesenchyme || cranial placode || neural fold || neurogenic placode || neuroectoderm || early distal tubule || neural plate || late distal tubule || distal tubule |
Kringle-like | 0.5334 | INHERITED FROM: epithelium || neural groove |
FnI-like domain | 0.5417 | INHERITED FROM: hypochord || endoderm || somite || notochord || epithelial cell |
P-loop containing nucleoside triphosphate hydrolases | 0.5732 | INHERITED FROM: olfactory sensory neuron |
Globin-like | 0.6027 | INHERITED FROM: hematopoietic stem cell || anterior dorsal lateral plate region || lateral plate mesoderm || anterior ventral blood island || ventral blood island |
Growth factor receptor domain | 0.6192 | INHERITED FROM: hypochord || otic vesicle || tail tip || pre-chordal neural plate border || notochord || mesenchyme || fin || anterior neural ridge |
TIMP-like | 0.6594 | INHERITED FROM: endoderm || stomodeal-hypophyseal primordium || pre-chordal neural plate || optic field |
Snake toxin-like | 0.6629 | INHERITED FROM: dorsal lateral plate mesoderm || mesoderm || chordal neural plate || lateral plate mesoderm || neuroectoderm || head mesenchyme || neural plate || mesenchyme || involuted dorsal mesoderm || pre-chordal neural plate || head mesoderm || ventral mesoderm |
Kazal-type serine protease inhibitors | 0.6865 | INHERITED FROM: hypochord || neural plate || notochord || neural groove |
Sema domain | 0.7295 | INHERITED FROM: neural crest || otic placode || cranial placode || neuroectoderm || cranial neural crest || involuted dorsal mesoderm |
Protein kinase-like (PK-like) | 0.7393 | INHERITED FROM: regenerating hindlimb || head mesoderm |
Integrin domains | 0.7999 | INHERITED FROM: fibroblast || mesodermal cell |
EGF/Laminin | 0.8005 | INHERITED FROM: hypochord || dorsal fin || notochord || neural groove |
Tropomyosin | 0.8288 | INHERITED FROM: myocyte || myocardium || dermomyotome || multilaminar epithelium || myotome |
PYP-like sensor domain (PAS domain) | 0.9521 | INHERITED FROM: mesoderm || epaxial muscle || somite |
Plexin repeat | 0.9966 | INHERITED FROM: neural crest || otic placode || cranial placode || neuroectoderm || cranial neural crest || involuted dorsal mesoderm |
Galactose-binding domain-like | 1 | INHERITED FROM: optic nerve |
Fibronectin type III | 1 | INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer |
TSP-1 type 1 repeat | 1 | INHERITED FROM: hypochord |
Family A G protein-coupled receptor-like | 1 | INHERITED FROM: granule cell layer of the olfactory bulb |
Metalloproteases ("zincins"), catalytic domain | 1 | INHERITED FROM: fibroblast || mesodermal cell || notochordal sheath |
Ras GEF | 1 | INHERITED FROM: retinal inner plexiform layer || retinal outer plexiform layer |
Cadherin-like | 1 | INHERITED FROM: neural crest || neuroectoderm |
Voltage-gated potassium channels | 1 | INHERITED FROM: nerve || optic nerve || retinal ganglion cell layer || retinal inner plexiform layer || cephalic nerve |
EF-hand | 1 | INHERITED FROM: myocyte |
Immunoglobulin | 1 | INHERITED FROM: retinal inner nuclear layer |
beta-beta-alpha zinc fingers | 1 | INHERITED FROM: chordal neural plate border || chordal neural plate || splanchnic layer of lateral plate mesoderm || neural fold || pre-chordal neural plate border || pre-chordal neural plate || anterior neural ridge |
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
Endosomal sorting complex assembly domain | 0 | Direct |
Zn-binding ribosomal proteins | 0 | Direct |
beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
14-3-3 protein | 0 | Direct |
TAFH domain-like | 0 | Direct |
NTF2-like | 0 | Direct |
Acyl-CoA binding protein | 0 | Direct |
Hedgehog/DD-peptidase | 0 | Direct |
PLP-binding barrel | 0 | Direct |
Surp module (SWAP domain) | 0 | Direct |
Zn-finger domain of Sec23/24 | 0 | Direct |
LuxS/MPP-like metallohydrolase | 0 | Direct |
Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
Mitochondrial cytochrome c oxidase subunit VIIa | 0 | Direct |
CoA-dependent acyltransferases | 0 | Direct |
TSP type-3 repeat | 0 | Direct |
Nop domain | 0 | Direct |
F1F0 ATP synthase subunit C | 0 | Direct |
DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
Mediator hinge subcomplex-like | 0 | Direct |
4Fe-4S ferredoxins | 0 | Direct |
alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
Synuclein | 0 | Direct |
Orange domain-like | 0 | Direct |
Sialidases | 0 | Direct |
FF domain | 0 | Direct |
N-acetylmuramoyl-L-alanine amidase-like | 0 | Direct |
PEBP-like | 0 | Direct |
SPOC domain-like | 0 | Direct |
Helical domain of Sec23/24 | 0 | Direct |
Nucleoplasmin-like core domain | 0 | Direct |
SAP domain | 0 | Direct |
Succinyl-CoA synthetase domains | 0 | Direct |
SIS domain | 0 | Direct |
Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | Direct |
TK C-terminal domain-like | 0 | Direct |
Sec63 N-terminal domain-like | 0 | Direct |
Connexin43 | 0 | Direct |
Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
LeuD/IlvD-like | 0 | Direct |
Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
GINS helical bundle-like | 0 | Direct |
SMAD MH1 domain | 0 | Direct |
GYF domain | 0 | Direct |
ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
FMT C-terminal domain-like | 0 | Direct |
HSP90 C-terminal domain | 0 | Direct |
Moesin tail domain | 0 | Direct |
GFP-like | 0 | Direct |
E2F-DP heterodimerization region | 0 | Direct |
DLC | 0 | Direct |
WGR domain-like | 0 | Direct |
alpha-catenin/vinculin-like | 0 | Direct |
Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
Clathrin adaptor appendage domain | 0 | Direct |
L-aspartase-like | 0 | Direct |
Class I glutamine amidotransferase-like | 0 | Direct |
G protein-binding domain | 0 | Direct |
Fibrinogen coiled-coil and central regions | 0 | Direct |
Trefoil | 0 | Direct |
Apolipoprotein A-I | 0 | Direct |
Subunits of heterodimeric actin filament capping protein Capz | 0 | Direct |
Uracil-DNA glycosylase-like | 0 | Direct |
post-AAA+ oligomerization domain-like | 0 | Direct |
Guanido kinase N-terminal domain | 0 | Direct |
Soluble quinoprotein glucose dehydrogenase | 0 | Direct |
Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
FAS1 domain | 0 | Direct |
Alpha-macroglobulin receptor domain | 0 | Direct |
Di-copper centre-containing domain | 0 | Direct |
BRK domain-like | 0 | Direct |
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
Ribosomal L27 protein-like | 0 | Direct |
BSD domain-like | 0 | Direct |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
SRF-like | 0 | Direct |
NAP-like | 0 | Direct |
Cation efflux protein cytoplasmic domain-like | 0 | Direct |
beta-sandwich domain of Sec23/24 | 0 | Direct |
Domain of poly(ADP-ribose) polymerase | 0 | Direct |
Nucleoporin domain | 0 | Direct |
BAG domain | 0 | Direct |
Ribosomal proteins L15p and L18e | 0 | Direct |
KA1-like | 0 | Direct |
Bromodomain | 0 | Direct |
Ribonuclease PH domain 2-like | 0 | Direct |
Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
Proteasome activator | 0 | Direct |
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
HSP40/DnaJ peptide-binding domain | 0 | Direct |
PAH2 domain | 0 | Direct |
Aconitase iron-sulfur domain | 0 | Direct |
RBP11-like subunits of RNA polymerase | 0 | Direct |
Tim10-like | 0 | Direct |
DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
Ribosomal protein L10-like | 0 | Direct |
Ferritin-like | 0 | Direct |
Mib/herc2 domain-like | 0 | Direct |
C-terminal domain of adenylylcyclase associated protein | 0 | Direct |
HRDC-like | 0 | Direct |
Ribulose-phoshate binding barrel | 0 | Direct |
Troponin coil-coiled subunits | 0 | Direct |
Translation proteins SH3-like domain | 0 | Direct |
ADP-ribosylglycohydrolase | 0 | Direct |
Arginase/deacetylase | 0 | Direct |
Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
Phosphoglucomutase, C-terminal domain | 0 | Direct |
Phosphoglucomutase, first 3 domains | 0 | Direct |
Alanine racemase C-terminal domain-like | 0 | Direct |
eIF4e-like | 0 | Direct |
PriA/YqbF domain | 0 | Direct |
Notch domain | 0 | Direct |
Cytokine | 0 | Direct |
Cap-Gly domain | 0 | Direct |
Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
MIR domain | 0 | Direct |
PAP/OAS1 substrate-binding domain | 0 | Direct |
RNA-binding domain, RBD | 0.000003256 | Direct |
Homeodomain-like | 0.000008008 | Direct |
"Winged helix" DNA-binding domain | 0.00003491 | Direct |
Nucleic acid-binding proteins | 0.0001925 | Direct |
HLH, helix-loop-helix DNA-binding domain | 0.0002936 | Direct |
UBC-like | 0.01269 | Inherited |
Thioredoxin-like | 0.0166 | Inherited |
Cyclin-like | 0.02027 | Inherited |
SET domain | 0.03153 | Inherited |
Actin depolymerizing proteins | 0.04465 | Inherited |
HSP20-like chaperones | 0.04862 | Inherited |
HMG-box | 0.05067 | Inherited |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0.08697 | Inherited |
ARID-like | 0.08697 | Inherited |
Glucocorticoid receptor-like (DNA-binding domain) | 0.09797 | Inherited |
GroEL equatorial domain-like | 0.1061 | Inherited |
Actin-like ATPase domain | 0.1101 | Inherited |
p53-like transcription factors | 0.1165 | Inherited |
Tubulin C-terminal domain-like | 0.1199 | Inherited |
BPTI-like | 0.1416 | Inherited |
Thiolase-like | 0.1445 | Inherited |
GroEL-intermediate domain like | 0.1445 | Inherited |
Second domain of FERM | 0.1731 | Inherited |
Transducin (alpha subunit), insertion domain | 0.215 | Inherited |
Spectrin repeat | 0.2152 | Inherited |
Translation proteins | 0.2152 | Inherited |
Tubulin nucleotide-binding domain-like | 0.2329 | Inherited |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.2386 | Inherited |
Hemopexin-like domain | 0.2732 | Inherited |
GroEL apical domain-like | 0.2956 | Inherited |
Myosin rod fragments | 0.3195 | Inherited |
SMAD/FHA domain | 0.3243 | Inherited |
Frizzled cysteine-rich domain | 0.3298 | Inherited |
Clavaminate synthase-like | 0.3462 | Inherited |
Phosphoglycerate mutase-like | 0.3511 | Inherited |
Annexin | 0.3716 | Inherited |
LDH C-terminal domain-like | 0.3767 | Inherited |
Pentein | 0.3767 | Inherited |
Intermediate filament protein, coiled coil region | 0.3814 | Inherited |
Cystine-knot cytokines | 0.4034 | Inherited |
PGBD-like | 0.4288 | Inherited |
lambda repressor-like DNA-binding domains | 0.4752 | Inherited |
Kringle-like | 0.5334 | Inherited |
FnI-like domain | 0.5417 | Inherited |
P-loop containing nucleoside triphosphate hydrolases | 0.5732 | Inherited |
Globin-like | 0.6027 | Inherited |
Growth factor receptor domain | 0.6192 | Inherited |
TIMP-like | 0.6594 | Inherited |
Snake toxin-like | 0.6629 | Inherited |
Kazal-type serine protease inhibitors | 0.6865 | Inherited |
Sema domain | 0.7295 | Inherited |
Protein kinase-like (PK-like) | 0.7393 | Inherited |
Integrin domains | 0.7999 | Inherited |
EGF/Laminin | 0.8005 | Inherited |
Tropomyosin | 0.8288 | Inherited |
PYP-like sensor domain (PAS domain) | 0.9521 | Inherited |
Plexin repeat | 0.9966 | Inherited |
Galactose-binding domain-like | 1 | Inherited |
Fibronectin type III | 1 | Inherited |
TSP-1 type 1 repeat | 1 | Inherited |
Family A G protein-coupled receptor-like | 1 | Inherited |
Metalloproteases ("zincins"), catalytic domain | 1 | Inherited |
Ras GEF | 1 | Inherited |
Cadherin-like | 1 | Inherited |
Voltage-gated potassium channels | 1 | Inherited |
EF-hand | 1 | Inherited |
Immunoglobulin | 1 | Inherited |
beta-beta-alpha zinc fingers | 1 | Inherited |
(show details)
Supra-domains annotated to this XA term (SPXA level: Least Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
82109,82109 82109 - MIR domain 82109 - MIR domain | 0 | DIRECT |
103647,49899 103647 - TSP type-3 repeat 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments | 0 | DIRECT |
88723,47807 88723 - PIN domain-like 47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
57196,100895 57196 - EGF/Laminin 100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
52540,53254 52540 - P-loop containing nucleoside triphosphate hydrolases 53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
53732,52016 53732 - Aconitase iron-sulfur domain 52016 - LeuD/IlvD-like | 0 | DIRECT |
54236,57889 54236 - Ubiquitin-like 57889 - Cysteine-rich domain | 0 | DIRECT |
49348,55711 49348 - Clathrin adaptor appendage domain 55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
63411,63411 63411 - LuxS/MPP-like metallohydrolase 63411 - LuxS/MPP-like metallohydrolase | 0 | DIRECT |
110324,50249 110324 - Ribosomal L27 protein-like 50249 - Nucleic acid-binding proteins | 0 | DIRECT |
117018,56091 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
54403,54403 54403 - Cystatin/monellin 54403 - Cystatin/monellin | 0 | DIRECT |
54511,57184 54511 - GFP-like 57184 - Growth factor receptor domain | 0 | DIRECT |
57184,57610 57184 - Growth factor receptor domain 57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
51419,50621 51419 - PLP-binding barrel 50621 - Alanine racemase C-terminal domain-like | 0 | DIRECT |
49899,52540 49899 - Concanavalin A-like lectins/glucanases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57756,57756 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
52518,52922 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52922 - TK C-terminal domain-like | 0 | DIRECT |
51045,56204 51045 - WW domain 56204 - Hect, E3 ligase catalytic domain | 0 | DIRECT |
46966,47473 46966 - Spectrin repeat 47473 - EF-hand | 0 | DIRECT |
100895,47473 100895 - Kazal-type serine protease inhibitors 47473 - EF-hand | 0 | DIRECT |
56645,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
51230,47005 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain | 0 | DIRECT |
142921,47587 142921 - WGR domain-like 47587 - Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
57196,50494 57196 - EGF/Laminin 50494 - Trypsin-like serine proteases | 0 | DIRECT |
90209,90209 90209 - Ran binding protein zinc finger-like 90209 - Ran binding protein zinc finger-like | 0 | DIRECT |
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain | 0 | DIRECT |
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like | 0 | DIRECT |
57196,56436 57196 - EGF/Laminin 56436 - C-type lectin-like | 0 | DIRECT |
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
52540,48019 52540 - P-loop containing nucleoside triphosphate hydrolases 48019 - post-AAA+ oligomerization domain-like | 0 | DIRECT |
52518,52518 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
47473,103506 47473 - EF-hand 103506 - Mitochondrial carrier | 0 | DIRECT |
56059,52210 56059 - Glutathione synthetase ATP-binding domain-like 52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
52425,48173 52425 - Cryptochrome/photolyase, N-terminal domain 48173 - Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
57196,90193 57196 - EGF/Laminin 90193 - Notch domain | 0 | DIRECT |
81301,81631 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain | 0 | DIRECT |
82615,82615 82615 - Polo-box domain 82615 - Polo-box domain | 0 | DIRECT |
52058,49265 52058 - L domain-like 49265 - Fibronectin type III | 0 | DIRECT |
56436,57535 56436 - C-type lectin-like 57535 - Complement control module/SCR domain | 0 | DIRECT |
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like | 0 | DIRECT |
57184,49265 57184 - Growth factor receptor domain 49265 - Fibronectin type III | 0 | DIRECT |
69012,55874 69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
47005,52777 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases | 0 | DIRECT |
81995,81811 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24 | 0 | DIRECT |
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like | 0 | DIRECT |
55550,55550 55550 - SH2 domain 55550 - SH2 domain | 0 | DIRECT |
81296,48239 81296 - E set domains 48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
53738,55957 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
82895,57424 82895 - TSP-1 type 1 repeat 57424 - LDL receptor-like module | 0 | DIRECT |
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
53300,81995 53300 - vWA-like 81995 - beta-sandwich domain of Sec23/24 | 0 | DIRECT |
52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
47095,47095 47095 - HMG-box 47095 - HMG-box | 0 | DIRECT |
48034,55931 48034 - Guanido kinase N-terminal domain 55931 - Glutamine synthetase/guanido kinase | 0 | DIRECT |
54211,55666 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like | 0 | DIRECT |
47203,47203 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
50044,50156 50044 - SH3-domain 50156 - PDZ domain-like | 0 | DIRECT |
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin | 0 | DIRECT |
53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
54534,54534 54534 - FKBP-like 54534 - FKBP-like | 0 | DIRECT |
47661,58038 47661 - t-snare proteins 58038 - SNARE fusion complex | 0 | DIRECT |
49854,57196 49854 - Spermadhesin, CUB domain 57196 - EGF/Laminin | 0 | DIRECT |
81811,82754 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
56091,50249 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins | 0 | DIRECT |
48371,46785 48371 - ARM repeat 46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
54631,54631 54631 - CBS-domain pair 54631 - CBS-domain pair | 0 | DIRECT |
54160,57850 54160 - Chromo domain-like 57850 - RING/U-box | 0 | DIRECT |
57938,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
55021,56534 55021 - ACT-like 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
47370,47370 47370 - Bromodomain 47370 - Bromodomain | 0 | DIRECT |
47587,56399 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation | 0 | DIRECT |
55486,48371 55486 - Metalloproteases ("zincins"), catalytic domain 48371 - ARM repeat | 0 | DIRECT |
57630,57196 57630 - GLA-domain 57196 - EGF/Laminin | 0 | DIRECT |
46565,57938 46565 - Chaperone J-domain 57938 - DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
49493,49493 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
82109,100909 82109 - MIR domain 100909 - IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
103647,103647 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat | 0 | DIRECT |
57184,100895 57184 - Growth factor receptor domain 100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
81698,81698 81698 - FF domain 81698 - FF domain | 0 | DIRECT |
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region | 0 | DIRECT |
82153,82153 82153 - FAS1 domain 82153 - FAS1 domain | 0 | DIRECT |
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases | 0 | DIRECT |
48726,56436 48726 - Immunoglobulin 56436 - C-type lectin-like | 0 | DIRECT |
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like | 0 | DIRECT |
54211,55060 54211 - Ribosomal protein S5 domain 2-like 55060 - GHMP Kinase, C-terminal domain | 0 | DIRECT |
161111,160240 161111 - Cation efflux protein transmembrane domain-like 160240 - Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD | 0.00001583 | DIRECT |
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.00381 | INHERITED FROM: preplacodal ectoderm || archenteron || nerve || sensorial layer of neurectoderm || zona limitans intrathalamica || trigeminal ganglion || otic vesicle || anterior placodal area || anterior dorsal lateral plate region || endoderm || archenteron floor || cranial placode || neuroectoderm || ventral blood island || cephalic nerve || post-anal gut |
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like | 0.07329 | INHERITED FROM: migratory neural crest cell || postmigratory neural crest cell |
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.08697 | INHERITED FROM: skeletal muscle |
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like | 0.1199 | INHERITED FROM: non-neural ectoderm || vagus nerve || epidermal cell || epidermis || epithelium || gastrocoel roof plate || trigeminal nerve || epithelial cell || glossopharyngeal nerve || facial nerve |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.1311 | INHERITED FROM: jaw muscle || myocyte || skeletal muscle || muscle || cranial muscle || head somite |
53901,53901 53901 - Thiolase-like 53901 - Thiolase-like | 0.1445 | INHERITED FROM: skeletal muscle |
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0.1846 | INHERITED FROM: skeletal muscle || muscle |
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.215 | INHERITED FROM: olfactory sensory neuron || olfactory epithelium |
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat | 0.2194 | INHERITED FROM: sensory epithelial cell || auditory hair cell || epithelial cell |
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.2359 | INHERITED FROM: skeletal muscle |
103575,48726 103575 - Plexin repeat 48726 - Immunoglobulin | 0.2359 | INHERITED FROM: neural crest || midbrain-hindbrain boundary || cranial placode || neuroectoderm || branchial crest || notochord || cranial neural crest |
57440,57440 57440 - Kringle-like 57440 - Kringle-like | 0.2359 | INHERITED FROM: neurogenic placode || mesenchyme |
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like | 0.2884 | INHERITED FROM: ganglion |
90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger | 0.3621 | INHERITED FROM: pronephric mesenchyme |
63501,50242 63501 - Frizzled cysteine-rich domain 50242 - TIMP-like | 0.3767 | INHERITED FROM: mesoderm || endoderm || neuroectoderm || neural plate || stomodeal-hypophyseal primordium || pre-chordal neural plate || optic field |
51735,56327 51735 - NAD(P)-binding Rossmann-fold domains 56327 - LDH C-terminal domain-like | 0.3767 | INHERITED FROM: skeletal tissue || skeletal muscle || connective tissue || bone tissue |
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like) | 0.3767 | INHERITED FROM: mesoderm || endoderm || neuroectoderm |
81383,52047 81383 - F-box domain 52047 - RNI-like | 0.404 | INHERITED FROM: neuroectoderm || cranial neural crest |
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0.404 | INHERITED FROM: presomitic mesoderm || notochord |
47090,55486 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain | 0.4288 | INHERITED FROM: notochord || notochordal sheath |
64593,64593 64593 - Intermediate filament protein, coiled coil region 64593 - Intermediate filament protein, coiled coil region | 0.4733 | INHERITED FROM: epidermis |
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like | 0.4913 | INHERITED FROM: pronephric tubule || chordal neural plate || retinal ganglion cell layer || cranial placode || neural fold || neurogenic placode || neuroectoderm || neural plate |
57603,57603 57603 - FnI-like domain 57603 - FnI-like domain | 0.5163 | INHERITED FROM: chordal neural plate || notochord |
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain | 0.5585 | INHERITED FROM: notochord |
55785,55785 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) | 0.6769 | INHERITED FROM: somite |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.6921 | INHERITED FROM: notochord || neural groove |
49785,57184 49785 - Galactose-binding domain-like 57184 - Growth factor receptor domain | 0.6971 | INHERITED FROM: mesenchyme |
52799,52799 52799 - (Phosphotyrosine protein) phosphatases II 52799 - (Phosphotyrosine protein) phosphatases II | 0.703 | INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer |
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.7107 | INHERITED FROM: non-involuting marginal zone |
101912,103575 101912 - Sema domain 103575 - Plexin repeat | 0.7295 | INHERITED FROM: neural crest || otic placode || cranial placode || neuroectoderm || cranial neural crest || involuted dorsal mesoderm |
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) | 0.8732 | INHERITED FROM: somite || ventral blood island |
56112,47769 56112 - Protein kinase-like (PK-like) 47769 - SAM/Pointed domain | 0.8982 | INHERITED FROM: branchial crest || cranial neural crest || mesenchyme |
52743,49785 52743 - Subtilisin-like 49785 - Galactose-binding domain-like | 0.8982 | INHERITED FROM: notochord |
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III | 0.9076 | INHERITED FROM: retinal inner nuclear layer |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.9518 | INHERITED FROM: neural plate border || chordal neural plate border || chordal neural plate || splanchnic layer of lateral plate mesoderm || anterior neural fold || lateral plate mesoderm || neural fold || neuroectoderm || pre-chordal neural plate border || neural plate || pre-chordal neural plate || anterior neural ridge |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 1 | INHERITED FROM: wound epidermis |
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like | 1 | INHERITED FROM: neural crest |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 1 | INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer |
50044,55550 50044 - SH3-domain 55550 - SH2 domain | 1 | INHERITED FROM: non-involuting marginal zone |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
82109,82109 82109 - MIR domain 82109 - MIR domain | 0 | Direct |
103647,49899 103647 - TSP type-3 repeat 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments | 0 | Direct |
88723,47807 88723 - PIN domain-like 47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
57196,100895 57196 - EGF/Laminin 100895 - Kazal-type serine protease inhibitors | 0 | Direct |
52540,53254 52540 - P-loop containing nucleoside triphosphate hydrolases 53254 - Phosphoglycerate mutase-like | 0 | Direct |
53732,52016 53732 - Aconitase iron-sulfur domain 52016 - LeuD/IlvD-like | 0 | Direct |
54236,57889 54236 - Ubiquitin-like 57889 - Cysteine-rich domain | 0 | Direct |
49348,55711 49348 - Clathrin adaptor appendage domain 55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
63411,63411 63411 - LuxS/MPP-like metallohydrolase 63411 - LuxS/MPP-like metallohydrolase | 0 | Direct |
110324,50249 110324 - Ribosomal L27 protein-like 50249 - Nucleic acid-binding proteins | 0 | Direct |
117018,56091 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
54403,54403 54403 - Cystatin/monellin 54403 - Cystatin/monellin | 0 | Direct |
54511,57184 54511 - GFP-like 57184 - Growth factor receptor domain | 0 | Direct |
57184,57610 57184 - Growth factor receptor domain 57610 - Thyroglobulin type-1 domain | 0 | Direct |
51419,50621 51419 - PLP-binding barrel 50621 - Alanine racemase C-terminal domain-like | 0 | Direct |
49899,52540 49899 - Concanavalin A-like lectins/glucanases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57756,57756 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains | 0 | Direct |
52518,52922 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52922 - TK C-terminal domain-like | 0 | Direct |
51045,56204 51045 - WW domain 56204 - Hect, E3 ligase catalytic domain | 0 | Direct |
46966,47473 46966 - Spectrin repeat 47473 - EF-hand | 0 | Direct |
100895,47473 100895 - Kazal-type serine protease inhibitors 47473 - EF-hand | 0 | Direct |
56645,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
51230,47005 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain | 0 | Direct |
142921,47587 142921 - WGR domain-like 47587 - Domain of poly(ADP-ribose) polymerase | 0 | Direct |
57196,50494 57196 - EGF/Laminin 50494 - Trypsin-like serine proteases | 0 | Direct |
90209,90209 90209 - Ran binding protein zinc finger-like 90209 - Ran binding protein zinc finger-like | 0 | Direct |
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain | 0 | Direct |
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like | 0 | Direct |
57196,56436 57196 - EGF/Laminin 56436 - C-type lectin-like | 0 | Direct |
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
52540,48019 52540 - P-loop containing nucleoside triphosphate hydrolases 48019 - post-AAA+ oligomerization domain-like | 0 | Direct |
52518,52518 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
47473,103506 47473 - EF-hand 103506 - Mitochondrial carrier | 0 | Direct |
56059,52210 56059 - Glutathione synthetase ATP-binding domain-like 52210 - Succinyl-CoA synthetase domains | 0 | Direct |
52425,48173 52425 - Cryptochrome/photolyase, N-terminal domain 48173 - Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
57196,90193 57196 - EGF/Laminin 90193 - Notch domain | 0 | Direct |
81301,81631 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain | 0 | Direct |
82615,82615 82615 - Polo-box domain 82615 - Polo-box domain | 0 | Direct |
52058,49265 52058 - L domain-like 49265 - Fibronectin type III | 0 | Direct |
56436,57535 56436 - C-type lectin-like 57535 - Complement control module/SCR domain | 0 | Direct |
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like | 0 | Direct |
57184,49265 57184 - Growth factor receptor domain 49265 - Fibronectin type III | 0 | Direct |
69012,55874 69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
47005,52777 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases | 0 | Direct |
81995,81811 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24 | 0 | Direct |
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like | 0 | Direct |
55550,55550 55550 - SH2 domain 55550 - SH2 domain | 0 | Direct |
81296,48239 81296 - E set domains 48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
53738,55957 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
82895,57424 82895 - TSP-1 type 1 repeat 57424 - LDL receptor-like module | 0 | Direct |
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
53300,81995 53300 - vWA-like 81995 - beta-sandwich domain of Sec23/24 | 0 | Direct |
52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain | 0 | Direct |
47095,47095 47095 - HMG-box 47095 - HMG-box | 0 | Direct |
48034,55931 48034 - Guanido kinase N-terminal domain 55931 - Glutamine synthetase/guanido kinase | 0 | Direct |
54211,55666 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like | 0 | Direct |
47203,47203 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like | 0 | Direct |
50044,50156 50044 - SH3-domain 50156 - PDZ domain-like | 0 | Direct |
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin | 0 | Direct |
53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
54534,54534 54534 - FKBP-like 54534 - FKBP-like | 0 | Direct |
47661,58038 47661 - t-snare proteins 58038 - SNARE fusion complex | 0 | Direct |
49854,57196 49854 - Spermadhesin, CUB domain 57196 - EGF/Laminin | 0 | Direct |
81811,82754 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
56091,50249 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins | 0 | Direct |
48371,46785 48371 - ARM repeat 46785 - "Winged helix" DNA-binding domain | 0 | Direct |
54631,54631 54631 - CBS-domain pair 54631 - CBS-domain pair | 0 | Direct |
54160,57850 54160 - Chromo domain-like 57850 - RING/U-box | 0 | Direct |
57938,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
55021,56534 55021 - ACT-like 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
47370,47370 47370 - Bromodomain 47370 - Bromodomain | 0 | Direct |
47587,56399 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation | 0 | Direct |
55486,48371 55486 - Metalloproteases ("zincins"), catalytic domain 48371 - ARM repeat | 0 | Direct |
57630,57196 57630 - GLA-domain 57196 - EGF/Laminin | 0 | Direct |
46565,57938 46565 - Chaperone J-domain 57938 - DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
49493,49493 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
82109,100909 82109 - MIR domain 100909 - IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
103647,103647 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat | 0 | Direct |
57184,100895 57184 - Growth factor receptor domain 100895 - Kazal-type serine protease inhibitors | 0 | Direct |
81698,81698 81698 - FF domain 81698 - FF domain | 0 | Direct |
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region | 0 | Direct |
82153,82153 82153 - FAS1 domain 82153 - FAS1 domain | 0 | Direct |
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases | 0 | Direct |
48726,56436 48726 - Immunoglobulin 56436 - C-type lectin-like | 0 | Direct |
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like | 0 | Direct |
54211,55060 54211 - Ribosomal protein S5 domain 2-like 55060 - GHMP Kinase, C-terminal domain | 0 | Direct |
161111,160240 161111 - Cation efflux protein transmembrane domain-like 160240 - Cation efflux protein cytoplasmic domain-like | 0 | Direct |
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD | 0.00001583 | Direct |
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.00381 | Inherited |
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like | 0.07329 | Inherited |
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.08697 | Inherited |
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like | 0.1199 | Inherited |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.1311 | Inherited |
53901,53901 53901 - Thiolase-like 53901 - Thiolase-like | 0.1445 | Inherited |
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0.1846 | Inherited |
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.215 | Inherited |
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat | 0.2194 | Inherited |
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.2359 | Inherited |
103575,48726 103575 - Plexin repeat 48726 - Immunoglobulin | 0.2359 | Inherited |
57440,57440 57440 - Kringle-like 57440 - Kringle-like | 0.2359 | Inherited |
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like | 0.2884 | Inherited |
90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger | 0.3621 | Inherited |
63501,50242 63501 - Frizzled cysteine-rich domain 50242 - TIMP-like | 0.3767 | Inherited |
51735,56327 51735 - NAD(P)-binding Rossmann-fold domains 56327 - LDH C-terminal domain-like | 0.3767 | Inherited |
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like) | 0.3767 | Inherited |
81383,52047 81383 - F-box domain 52047 - RNI-like | 0.404 | Inherited |
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0.404 | Inherited |
47090,55486 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain | 0.4288 | Inherited |
64593,64593 64593 - Intermediate filament protein, coiled coil region 64593 - Intermediate filament protein, coiled coil region | 0.4733 | Inherited |
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like | 0.4913 | Inherited |
57603,57603 57603 - FnI-like domain 57603 - FnI-like domain | 0.5163 | Inherited |
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain | 0.5585 | Inherited |
55785,55785 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) | 0.6769 | Inherited |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.6921 | Inherited |
49785,57184 49785 - Galactose-binding domain-like 57184 - Growth factor receptor domain | 0.6971 | Inherited |
52799,52799 52799 - (Phosphotyrosine protein) phosphatases II 52799 - (Phosphotyrosine protein) phosphatases II | 0.703 | Inherited |
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.7107 | Inherited |
101912,103575 101912 - Sema domain 103575 - Plexin repeat | 0.7295 | Inherited |
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) | 0.8732 | Inherited |
56112,47769 56112 - Protein kinase-like (PK-like) 47769 - SAM/Pointed domain | 0.8982 | Inherited |
52743,49785 52743 - Subtilisin-like 49785 - Galactose-binding domain-like | 0.8982 | Inherited |
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III | 0.9076 | Inherited |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.9518 | Inherited |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 1 | Inherited |
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like | 1 | Inherited |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 1 | Inherited |
50044,55550 50044 - SH3-domain 55550 - SH2 domain | 1 | Inherited |
(show details)
Supra-domains annotated to this XA term (SPXA level: Least Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,57184,57196 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0 | DIRECT |
54791,54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
57938,49493,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
90257,90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments 90257 - Myosin rod fragments | 0 | DIRECT |
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain | 0 | DIRECT |
52058,49265,49265 52058 - L domain-like 49265 - Fibronectin type III 49265 - Fibronectin type III | 0 | DIRECT |
63737,55486,48371 63737 - Leukotriene A4 hydrolase N-terminal domain 55486 - Metalloproteases ("zincins"), catalytic domain 48371 - ARM repeat | 0 | DIRECT |
57196,57196,49899 57196 - EGF/Laminin 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
53300,81995,81811 53300 - vWA-like 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24 | 0 | DIRECT |
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0 | DIRECT |
57196,49854,57535 57196 - EGF/Laminin 49854 - Spermadhesin, CUB domain 57535 - Complement control module/SCR domain | 0 | DIRECT |
57630,57196,57196 57630 - GLA-domain 57196 - EGF/Laminin 57196 - EGF/Laminin | 0 | DIRECT |
51338,51556,51338 51338 - Composite domain of metallo-dependent hydrolases 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
54768,54768,54768 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like | 0 | DIRECT |
56645,47203,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
46565,57938,49493 46565 - Chaperone J-domain 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
103647,103647,49899 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57440,57440,57440 57440 - Kringle-like 57440 - Kringle-like 57440 - Kringle-like | 0 | DIRECT |
81995,81811,82754 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
53738,53738,55957 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
142921,47587,56399 142921 - WGR domain-like 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation | 0 | DIRECT |
49854,57196,49854 49854 - Spermadhesin, CUB domain 57196 - EGF/Laminin 49854 - Spermadhesin, CUB domain | 0 | DIRECT |
49785,49785,49899 49785 - Galactose-binding domain-like 49785 - Galactose-binding domain-like 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
117018,56091,50249 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins | 0 | DIRECT |
51045,51045,56204 51045 - WW domain 51045 - WW domain 56204 - Hect, E3 ligase catalytic domain | 0 | DIRECT |
47220,47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
47769,47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain | 0 | DIRECT |
50249,50249,50249 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins | 0 | DIRECT |
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like | 0 | DIRECT |
48726,56436,56436 48726 - Immunoglobulin 56436 - C-type lectin-like 56436 - C-type lectin-like | 0 | DIRECT |
53738,53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
57196,57184,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0 | DIRECT |
54160,57850,57845 54160 - Chromo domain-like 57850 - RING/U-box 57845 - B-box zinc-binding domain | 0 | DIRECT |
57184,52058,49265 57184 - Growth factor receptor domain 52058 - L domain-like 49265 - Fibronectin type III | 0 | DIRECT |
52833,52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like 52833 - Thioredoxin-like | 0 | DIRECT |
57184,57196,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57196 - EGF/Laminin | 0 | DIRECT |
82109,82109,100909 82109 - MIR domain 82109 - MIR domain 100909 - IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
51230,47005,52777 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases | 0 | DIRECT |
103647,103647,103647 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat | 0 | DIRECT |
46966,46966,47473 46966 - Spectrin repeat 46966 - Spectrin repeat 47473 - EF-hand | 0 | DIRECT |
57196,49899,57196 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin | 0 | DIRECT |
54511,57184,57184 54511 - GFP-like 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0 | DIRECT |
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.08697 | INHERITED FROM: skeletal muscle |
48371,48371,48371 48371 - ARM repeat 48371 - ARM repeat 48371 - ARM repeat | 0.1416 | INHERITED FROM: tail somite || tail tip || trunk somite || chordoneural hinge |
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat | 0.215 | INHERITED FROM: sensory epithelial cell || auditory hair cell || epithelial cell |
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.2359 | INHERITED FROM: skeletal muscle |
101912,103575,48726 101912 - Sema domain 103575 - Plexin repeat 48726 - Immunoglobulin | 0.2359 | INHERITED FROM: neural crest || midbrain-hindbrain boundary || cranial placode || neuroectoderm || branchial crest || notochord || cranial neural crest |
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.2785 | INHERITED FROM: notochord || non-neurogenic ectodermal placode |
57603,57603,57603 57603 - FnI-like domain 57603 - FnI-like domain 57603 - FnI-like domain | 0.2974 | INHERITED FROM: notochord |
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.3716 | INHERITED FROM: non-involuting marginal zone || mesoderm || otic vesicle || anterior neural fold || neural fold || neuroectoderm || neural plate || pre-chordal neural plate |
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain | 0.3716 | INHERITED FROM: sensorial layer of neurectoderm || presomitic mesoderm || anterior placodal area || anterior neural fold || tail tip |
47459,55785,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) | 0.44 | INHERITED FROM: somite |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.539 | INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer |
47090,55486,50923 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain | 0.703 | INHERITED FROM: notochord |
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0.7259 | INHERITED FROM: notochord |
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 1 | INHERITED FROM: splanchnic layer of lateral plate mesoderm |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 1 | INHERITED FROM: wound epidermis || pharyngeal mesenchyme |
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like | 1 | INHERITED FROM: neural crest || neuroectoderm |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,57184,57196 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0 | Direct |
54791,54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
57938,49493,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
90257,90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments 90257 - Myosin rod fragments | 0 | Direct |
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain | 0 | Direct |
52058,49265,49265 52058 - L domain-like 49265 - Fibronectin type III 49265 - Fibronectin type III | 0 | Direct |
63737,55486,48371 63737 - Leukotriene A4 hydrolase N-terminal domain 55486 - Metalloproteases ("zincins"), catalytic domain 48371 - ARM repeat | 0 | Direct |
57196,57196,49899 57196 - EGF/Laminin 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
53300,81995,81811 53300 - vWA-like 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24 | 0 | Direct |
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0 | Direct |
57196,49854,57535 57196 - EGF/Laminin 49854 - Spermadhesin, CUB domain 57535 - Complement control module/SCR domain | 0 | Direct |
57630,57196,57196 57630 - GLA-domain 57196 - EGF/Laminin 57196 - EGF/Laminin | 0 | Direct |
51338,51556,51338 51338 - Composite domain of metallo-dependent hydrolases 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases | 0 | Direct |
54768,54768,54768 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like | 0 | Direct |
56645,47203,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
46565,57938,49493 46565 - Chaperone J-domain 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
103647,103647,49899 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57440,57440,57440 57440 - Kringle-like 57440 - Kringle-like 57440 - Kringle-like | 0 | Direct |
81995,81811,82754 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
53738,53738,55957 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
142921,47587,56399 142921 - WGR domain-like 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation | 0 | Direct |
49854,57196,49854 49854 - Spermadhesin, CUB domain 57196 - EGF/Laminin 49854 - Spermadhesin, CUB domain | 0 | Direct |
49785,49785,49899 49785 - Galactose-binding domain-like 49785 - Galactose-binding domain-like 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
117018,56091,50249 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins | 0 | Direct |
51045,51045,56204 51045 - WW domain 51045 - WW domain 56204 - Hect, E3 ligase catalytic domain | 0 | Direct |
47220,47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like | 0 | Direct |
47769,47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain | 0 | Direct |
50249,50249,50249 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins | 0 | Direct |
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like | 0 | Direct |
48726,56436,56436 48726 - Immunoglobulin 56436 - C-type lectin-like 56436 - C-type lectin-like | 0 | Direct |
53738,53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
57196,57184,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0 | Direct |
54160,57850,57845 54160 - Chromo domain-like 57850 - RING/U-box 57845 - B-box zinc-binding domain | 0 | Direct |
57184,52058,49265 57184 - Growth factor receptor domain 52058 - L domain-like 49265 - Fibronectin type III | 0 | Direct |
52833,52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like 52833 - Thioredoxin-like | 0 | Direct |
57184,57196,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57196 - EGF/Laminin | 0 | Direct |
82109,82109,100909 82109 - MIR domain 82109 - MIR domain 100909 - IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
51230,47005,52777 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases | 0 | Direct |
103647,103647,103647 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat | 0 | Direct |
46966,46966,47473 46966 - Spectrin repeat 46966 - Spectrin repeat 47473 - EF-hand | 0 | Direct |
57196,49899,57196 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin | 0 | Direct |
54511,57184,57184 54511 - GFP-like 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0 | Direct |
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.08697 | Inherited |
48371,48371,48371 48371 - ARM repeat 48371 - ARM repeat 48371 - ARM repeat | 0.1416 | Inherited |
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat | 0.215 | Inherited |
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.2359 | Inherited |
101912,103575,48726 101912 - Sema domain 103575 - Plexin repeat 48726 - Immunoglobulin | 0.2359 | Inherited |
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.2785 | Inherited |
57603,57603,57603 57603 - FnI-like domain 57603 - FnI-like domain 57603 - FnI-like domain | 0.2974 | Inherited |
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.3716 | Inherited |
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain | 0.3716 | Inherited |
47459,55785,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) | 0.44 | Inherited |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.539 | Inherited |
47090,55486,50923 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain | 0.703 | Inherited |
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0.7259 | Inherited |
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 1 | Inherited |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 1 | Inherited |
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like | 1 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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