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Xenopus ANatomical entity (XAN): head region
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: XA Hierarchy (Xenopus anatomy and development from Xenbase frog anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this XA term (Not in SDXA)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| ClpS-like | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Cytochrome b5-like heme/steroid binding domain | 0 | DIRECT |
| Homocysteine S-methyltransferase | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| Oligoxyloglucan reducing end-specific cellobiohydrolase | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| ThrRS/AlaRS common domain | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Sialidases | 0 | DIRECT |
| Mannose 6-phosphate receptor domain | 0 | DIRECT |
| USP8 N-terminal domain-like | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| KA1-like | 0 | DIRECT |
| GFP-like | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| Dimeric alpha+beta barrel | 0 | DIRECT |
| Stathmin | 0 | DIRECT |
| E2F-DP heterodimerization region | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| Pentein | 0 | DIRECT |
| Ligand-binding domain in the NO signalling and Golgi transport | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
| RNase III domain-like | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| post-AAA+ oligomerization domain-like | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Mediator hinge subcomplex-like | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| NAP-like | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| L30e-like | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
| GINS helical bundle-like | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Prefoldin | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Endosomal sorting complex assembly domain | 0 | DIRECT |
| Mib/herc2 domain-like | 0 | DIRECT |
| ARID-like | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| PriA/YqbF domain | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| Glycoside hydrolase/deacetylase | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| S15/NS1 RNA-binding domain | 0 | DIRECT |
| Cysteine alpha-hairpin motif | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | DIRECT |
| ACP-like | 0 | DIRECT |
| Mss4-like | 0 | DIRECT |
| I/LWEQ domain | 0 | DIRECT |
| alpha/beta knot | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Sm-like ribonucleoproteins | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
| MAST3 pre-PK domain-like | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| ACT-like | 0 | DIRECT |
| Glutamine synthetase/guanido kinase | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| TGS-like | 0 | DIRECT |
| THUMP domain-like | 0 | DIRECT |
| Globin-like | 0 | DIRECT |
| Actin-crosslinking proteins | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| AraD/HMP-PK domain-like | 0 | DIRECT |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | DIRECT |
| HRDC-like | 0 | DIRECT |
| FAD-binding/transporter-associated domain-like | 0 | DIRECT |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
| Cyclophilin-like | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
| Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| BSD domain-like | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| Uracil-DNA glycosylase-like | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| Hedgehog/DD-peptidase | 0 | DIRECT |
| ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Hook domain | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| Enolase C-terminal domain-like | 0 | DIRECT |
| DLC | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| TNF receptor-like | 0 | DIRECT |
| Chromo domain-like | 0 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| LuxS/MPP-like metallohydrolase | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| RUN domain-like | 0 | DIRECT |
| Cullin repeat-like | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Cytokine | 0 | DIRECT |
| Acyl-CoA binding protein | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| Ribosomal L27 protein-like | 0 | DIRECT |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
| eIF1-like | 0 | DIRECT |
| Di-copper centre-containing domain | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Ubiquitin-like | 0.00085 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0.008284 | INHERITED FROM: m. interhyoideus || cranial ganglion || periocular region || head vasculature || ventricular zone || retinal ganglion cell layer || eye || forebrain || cranium || retinal inner nuclear layer || hindbrain || retinal outer nuclear layer || midbrain || pharyngeal arch || olfactory region || retinal stem cell region || hyoid head muscle || musculature of face || pharyngeal region || cranial muscle |
| HMG-box | 0.01902 | INHERITED FROM: midbrain-hindbrain boundary || forebrain || hindbrain || pharyngeal arch || splanchnocranium || pharyngeal region |
| RNA-binding domain, RBD | 0.03478 | INHERITED FROM: eye || hindbrain || pharyngeal arch || pharyngeal region |
| Frizzled cysteine-rich domain | 0.07915 | INHERITED FROM: midbrain-hindbrain boundary || eye || forebrain || hindbrain || midbrain || pharyngeal arch || pharyngeal region |
| "Winged helix" DNA-binding domain | 0.08858 | INHERITED FROM: head mesoderm || periocular region || eye || pharyngeal arch || visceral pouch || pharyngeal region |
| Homeodomain-like | 0.09993 | INHERITED FROM: medial septum || pharyngeal endoderm || basal forebrain || midbrain-hindbrain boundary || olfactory bulb || thalamus || lateral pallium || cephalic nerve || ventricular zone || dorsal thalamus || amygdala || ventral pallium || retinal ganglion cell layer || septum || prosomere || neurocranium || eye || forebrain || mouth || cranium || retinal inner nuclear layer || ventral septum || prethalamus || lateral ganglionic eminence || hypothalamus || basal ganglion || telencephalon || rhombomere || hindbrain || medial ganglionic eminence || retinal pigmented epithelium || zona limitans intrathalamica || midbrain || pharyngeal arch || olfactory region || lateral septum || subpallium || pharyngeal pouch || preoptic area || anterior hypothalamus || periotic region || pallium || head mesenchyme || infundibulum || visceral pouch || pallidum || posterior hypothalamus || lower jaw || pharyngeal region || pretectum || diencephalon || optic tract || optic stalk |
| Tubulin C-terminal domain-like | 0.13 | INHERITED FROM: glossopharyngeal nerve || facial nerve || vagus nerve || trigeminal nerve |
| Phosphoglycerate mutase-like | 0.1644 | INHERITED FROM: head mesenchyme |
| Protein kinase-like (PK-like) | 0.1684 | INHERITED FROM: head mesoderm |
| Snake toxin-like | 0.1891 | INHERITED FROM: head mesoderm || head mesenchyme |
| PYP-like sensor domain (PAS domain) | 0.2214 | INHERITED FROM: eye |
| Orange domain-like | 0.2265 | INHERITED FROM: eye || midbrain || pharyngeal region |
| Ras GEF | 0.2745 | INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer |
| Tubulin nucleotide-binding domain-like | 0.305 | INHERITED FROM: glossopharyngeal nerve || facial nerve || vagus nerve || trigeminal nerve |
| PH domain-like | 0.3307 | INHERITED FROM: brain |
| p53-like transcription factors | 0.4083 | INHERITED FROM: ceratohyal || branchial arch skeleton || Meckel's cartilage || facial nerve || pharyngeal arch || chondrocranium || lower jaw || pharyngeal region |
| Voltage-gated potassium channels | 0.5776 | INHERITED FROM: retinal neural layer || cephalic nerve || retinal ganglion cell layer || optic nerve || retinal inner plexiform layer || optic disc |
| Myosin rod fragments | 0.6028 | INHERITED FROM: musculature of face |
| Sema domain | 0.6293 | INHERITED FROM: periocular region || branchial arch |
| gamma-Crystallin-like | 0.7081 | INHERITED FROM: lens |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.7206 | INHERITED FROM: medial septum || optic tectum || basal forebrain || thalamus || amygdala || ventral pallium || septum || prosomere || ventrolateral thalamic nucleus || forebrain || ventral septum || hypothalamus || basal ganglion || hindbrain || zona limitans intrathalamica || midbrain || lateral septum || subpallium || preoptic area || anterior hypothalamus || striatum || pretectum || diencephalon |
| Intermediate filament protein, coiled coil region | 0.7376 | INHERITED FROM: cephalic nerve || ventricular zone || retinal ganglion cell layer || retinal ganglion cell || retinal inner nuclear layer || optic nerve || midbrain tegmentum || retinal inner plexiform layer || medulla oblongata |
| Plexin repeat | 0.8197 | INHERITED FROM: periocular region || branchial arch |
| Actin-like ATPase domain | 0.825 | INHERITED FROM: jaw muscle || head somite || cranial muscle |
| Fibronectin type III | 0.8938 | INHERITED FROM: retinal neural layer || retinal ganglion cell layer || retinal inner nuclear layer |
| POZ domain | 1 | INHERITED FROM: optic disc |
| Cystine-knot cytokines | 1 | INHERITED FROM: head mesoderm || periocular region || branchial arch 3 || branchial arch 2 || head mesenchyme |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: medial pallium || basal forebrain || amygdala || granule cell layer of the olfactory bulb || septum || hypothalamus || basal ganglion || preoptic area || anterior hypothalamus || pallium || striatum || diencephalon |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| ClpS-like | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Cytochrome b5-like heme/steroid binding domain | 0 | Direct |
| Homocysteine S-methyltransferase | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| Enolase N-terminal domain-like | 0 | Direct |
| PAH2 domain | 0 | Direct |
| Oligoxyloglucan reducing end-specific cellobiohydrolase | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| ThrRS/AlaRS common domain | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Sialidases | 0 | Direct |
| Mannose 6-phosphate receptor domain | 0 | Direct |
| USP8 N-terminal domain-like | 0 | Direct |
| Synuclein | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| KA1-like | 0 | Direct |
| GFP-like | 0 | Direct |
| GroEL-intermediate domain like | 0 | Direct |
| Dimeric alpha+beta barrel | 0 | Direct |
| Stathmin | 0 | Direct |
| E2F-DP heterodimerization region | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Tim10-like | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| Pentein | 0 | Direct |
| Ligand-binding domain in the NO signalling and Golgi transport | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| Families 57/38 glycoside transferase middle domain | 0 | Direct |
| RNase III domain-like | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| NTF2-like | 0 | Direct |
| BEACH domain | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| post-AAA+ oligomerization domain-like | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Mediator hinge subcomplex-like | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| NAP-like | 0 | Direct |
| LeuD/IlvD-like | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| L30e-like | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
| GINS helical bundle-like | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Prefoldin | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| Endosomal sorting complex assembly domain | 0 | Direct |
| Mib/herc2 domain-like | 0 | Direct |
| ARID-like | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| PriA/YqbF domain | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| Glycoside hydrolase/deacetylase | 0 | Direct |
| MIR domain | 0 | Direct |
| S15/NS1 RNA-binding domain | 0 | Direct |
| Cysteine alpha-hairpin motif | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | Direct |
| ACP-like | 0 | Direct |
| Mss4-like | 0 | Direct |
| I/LWEQ domain | 0 | Direct |
| alpha/beta knot | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Sm-like ribonucleoproteins | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| FAS1 domain | 0 | Direct |
| IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
| MAST3 pre-PK domain-like | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| FF domain | 0 | Direct |
| ACT-like | 0 | Direct |
| Glutamine synthetase/guanido kinase | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| TGS-like | 0 | Direct |
| THUMP domain-like | 0 | Direct |
| Globin-like | 0 | Direct |
| Actin-crosslinking proteins | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| CCHHC domain | 0 | Direct |
| AraD/HMP-PK domain-like | 0 | Direct |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | Direct |
| HRDC-like | 0 | Direct |
| FAD-binding/transporter-associated domain-like | 0 | Direct |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
| Cyclophilin-like | 0 | Direct |
| Polo-box domain | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
| Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | Direct |
| Plakin repeat | 0 | Direct |
| BSD domain-like | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| Uracil-DNA glycosylase-like | 0 | Direct |
| GYF domain | 0 | Direct |
| Hedgehog/DD-peptidase | 0 | Direct |
| ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Hook domain | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| Enolase C-terminal domain-like | 0 | Direct |
| DLC | 0 | Direct |
| Nop domain | 0 | Direct |
| TNF receptor-like | 0 | Direct |
| Chromo domain-like | 0 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
| Notch domain | 0 | Direct |
| LuxS/MPP-like metallohydrolase | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| RUN domain-like | 0 | Direct |
| Cullin repeat-like | 0 | Direct |
| SRF-like | 0 | Direct |
| Cytokine | 0 | Direct |
| Acyl-CoA binding protein | 0 | Direct |
| LEM domain | 0 | Direct |
| Ribosomal L27 protein-like | 0 | Direct |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
| eIF1-like | 0 | Direct |
| Di-copper centre-containing domain | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Ubiquitin-like | 0.00085 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0.008284 | Inherited |
| HMG-box | 0.01902 | Inherited |
| RNA-binding domain, RBD | 0.03478 | Inherited |
| Frizzled cysteine-rich domain | 0.07915 | Inherited |
| "Winged helix" DNA-binding domain | 0.08858 | Inherited |
| Homeodomain-like | 0.09993 | Inherited |
| Tubulin C-terminal domain-like | 0.13 | Inherited |
| Phosphoglycerate mutase-like | 0.1644 | Inherited |
| Protein kinase-like (PK-like) | 0.1684 | Inherited |
| Snake toxin-like | 0.1891 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.2214 | Inherited |
| Orange domain-like | 0.2265 | Inherited |
| Ras GEF | 0.2745 | Inherited |
| Tubulin nucleotide-binding domain-like | 0.305 | Inherited |
| PH domain-like | 0.3307 | Inherited |
| p53-like transcription factors | 0.4083 | Inherited |
| Voltage-gated potassium channels | 0.5776 | Inherited |
| Myosin rod fragments | 0.6028 | Inherited |
| Sema domain | 0.6293 | Inherited |
| gamma-Crystallin-like | 0.7081 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.7206 | Inherited |
| Intermediate filament protein, coiled coil region | 0.7376 | Inherited |
| Plexin repeat | 0.8197 | Inherited |
| Actin-like ATPase domain | 0.825 | Inherited |
| Fibronectin type III | 0.8938 | Inherited |
| POZ domain | 1 | Inherited |
| Cystine-knot cytokines | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this XA term (Not in SDXA)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Stathmin | 0 | DIRECT |
| Hedgehog (development protein), N-terminal signaling domain | 0 | DIRECT |
| Ferritin | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
| Trunk domain of Sec23/24 | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | DIRECT |
| PreBEACH PH-like domain | 0 | DIRECT |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | DIRECT |
| IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| ARID domain | 0 | DIRECT |
| ENTH domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | DIRECT |
| LeuD-like | 0 | DIRECT |
| Pumilio repeat | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| APC10-like | 0 | DIRECT |
| Cation efflux protein transmembrane domain-like | 0 | DIRECT |
| Hook domain | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| eIF1-like | 0 | DIRECT |
| UDP-glucose pyrophosphorylase | 0 | DIRECT |
| I/LWEQ domain | 0 | DIRECT |
| Mib/herc2 domain | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | DIRECT |
| Adenain-like | 0 | DIRECT |
| Cofactor-dependent phosphoglycerate mutase | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| TNF receptor-like | 0 | DIRECT |
| Glyoxalase II (hydroxyacylglutathione hydrolase) | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| PUA domain | 0 | DIRECT |
| Linker histone H1/H5 | 0 | DIRECT |
| E2F dimerization segment | 0 | DIRECT |
| alpha-mannosidase | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| HD domain | 0 | DIRECT |
| Cytochrome b5 | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| Cell cycle transcription factor e2f-dp | 0 | DIRECT |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
| Protein-L-isoaspartyl O-methyltransferase | 0 | DIRECT |
| GS domain | 0 | DIRECT |
| HCDH C-domain-like | 0 | DIRECT |
| Mannose 6-phosphate receptor domain | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| HAT/Suf repeat | 0 | DIRECT |
| Fumble-like | 0 | DIRECT |
| DNA gyrase/MutL, second domain | 0 | DIRECT |
| RUNT domain | 0 | DIRECT |
| CUE domain | 0 | DIRECT |
| DNA polymerase III clamp loader subunits, C-terminal domain | 0 | DIRECT |
| Prefoldin | 0 | DIRECT |
| gamma-adaptin C-terminal appendage domain-like | 0 | DIRECT |
| Guanido kinase catalytic domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| Globins | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Histone deacetylase, HDAC | 0 | DIRECT |
| Gonadodropin/Follitropin | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| TRASH domain | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| NIPSNAP | 0 | DIRECT |
| Cyclophilin (peptidylprolyl isomerase) | 0 | DIRECT |
| DNA ligase | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Glycosyl transferases group 1 | 0 | DIRECT |
| Paired domain | 0 | DIRECT |
| Pointed domain | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| Phenylalanine metabolism regulatory domain | 0 | DIRECT |
| MPP-like | 0 | DIRECT |
| Autophagin-like | 0 | DIRECT |
| Hect, E3 ligase catalytic domain | 0 | DIRECT |
| Histone lysine methyltransferases | 0 | DIRECT |
| Alpha-adaptin ear subdomain-like | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| IF2B-like | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| BC C-terminal domain-like | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Acyl-CoA binding protein | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| SIAH, seven in absentia homolog | 0 | DIRECT |
| GABARAP-like | 0 | DIRECT |
| R3H domain | 0 | DIRECT |
| L30e/L7ae ribosomal proteins | 0 | DIRECT |
| Sedlin (SEDL) | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| RNA-polymerase beta-prime | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | DIRECT |
| ATP-dependent DNA ligase catalytic domain | 0 | DIRECT |
| Phoshatidylinositol transfer protein, PITP | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| MSP-like | 0 | DIRECT |
| DLC | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
| Chromo domain | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| Variant RING domain | 0 | DIRECT |
| alpha-mannosidase, domain 2 | 0 | DIRECT |
| Alanine racemase-like, N-terminal domain | 0 | DIRECT |
| Other IPT/TIG domains | 0 | DIRECT |
| RPR domain (SMART 00582 ) | 0 | DIRECT |
| Ephrin receptor ligand binding domain | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Transcriptional factor domain | 0 | DIRECT |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| USP8 N-terminal domain-like | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Arrestin/Vps26-like | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| ZZ domain | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | DIRECT |
| Homocysteine S-methyltransferase | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| DIX domain | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| MAST3 pre-PK domain-like | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| Noggin | 0 | DIRECT |
| Eukaryotic ODC-like | 0 | DIRECT |
| Tim10/DDP | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| NAP-like | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| Cyclin A/CDK2-associated p19, Skp2 | 0 | DIRECT |
| 4HBT-like | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Phosducin | 0 | DIRECT |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0 | DIRECT |
| alpha-mannosidase, C-terminal domain | 0 | DIRECT |
| Carboxylesterase/thioesterase 1 | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| alpha-catenin/vinculin | 0 | DIRECT |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | DIRECT |
| A20-like zinc finger | 0 | DIRECT |
| SCF ubiquitin ligase complex WHB domain | 0 | DIRECT |
| Domain G2 of nidogen-1 | 0 | DIRECT |
| Carboxylesterase | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | DIRECT |
| ECR1 N-terminal domain-like | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| P4 origin-binding domain-like | 0 | DIRECT |
| 1,3-glucuronyltransferase | 0 | DIRECT |
| Threonyl-tRNA synthetase (ThrRS), second 'additional' domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| AAT-like | 0 | DIRECT |
| Chromo barrel domain | 0 | DIRECT |
| BSD domain | 0 | DIRECT |
| TRAPP components | 0 | DIRECT |
| Phosphoribosylpyrophosphate synthetase-like | 0 | DIRECT |
| Steroid-binding domain | 0 | DIRECT |
| Ran-binding domain | 0 | DIRECT |
| S-adenosylhomocystein hydrolase | 0 | DIRECT |
| DJ-1/PfpI | 0 | DIRECT |
| Transferrin | 0 | DIRECT |
| Kinase associated domain 1, KA1 | 0 | DIRECT |
| RhoGDI-like | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| DNA gyrase/MutL, N-terminal domain | 0 | DIRECT |
| Fibroblast growth factors (FGF) | 0 | DIRECT |
| SH3BGR (SH3-binding, glutamic acid-rich protein-like) | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| Cytidylyltransferase | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Ephrin ectodomain | 0 | DIRECT |
| a tRNA synthase domain | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| Polo-box duplicated region | 0 | DIRECT |
| RUN domain | 0 | DIRECT |
| Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| AraD-like aldolase/epimerase | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
| Arginine methyltransferase | 0 | DIRECT |
| GDI-like N domain | 0 | DIRECT |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | DIRECT |
| B56-like | 0 | DIRECT |
| HEAT repeat | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0.007389 | INHERITED FROM: m. interhyoideus || cranial ganglion || periocular region || head vasculature || ventricular zone || retinal ganglion cell layer || eye || forebrain || cranium || retinal inner nuclear layer || hindbrain || retinal outer nuclear layer || midbrain || pharyngeal arch || olfactory region || retinal stem cell region || hyoid head muscle || musculature of face || pharyngeal region || cranial muscle |
| Second domain of FERM | 0.01172 | INHERITED FROM: trigeminal nerve |
| HMG-box | 0.01657 | INHERITED FROM: midbrain-hindbrain boundary || forebrain || hindbrain || pharyngeal arch || splanchnocranium || pharyngeal region |
| Canonical RBD | 0.02372 | INHERITED FROM: eye || hindbrain || pharyngeal arch || pharyngeal region |
| Forkhead DNA-binding domain | 0.03137 | INHERITED FROM: head mesoderm || periocular region || eye || cranium || pharyngeal arch || olfactory region || visceral pouch || pharyngeal region |
| Frizzled cysteine-rich domain | 0.06981 | INHERITED FROM: midbrain-hindbrain boundary || eye || forebrain || hindbrain || midbrain || pharyngeal arch || pharyngeal region |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.0919 | INHERITED FROM: retinal ganglion cell layer || retinal inner nuclear layer |
| Glutathione peroxidase-like | 0.1102 | INHERITED FROM: cranium || splanchnocranium |
| ets domain | 0.1103 | INHERITED FROM: periocular region || eye || pharyngeal arch || pharyngeal region |
| Tubulin, GTPase domain | 0.1165 | INHERITED FROM: glossopharyngeal nerve || facial nerve || vagus nerve || trigeminal nerve |
| Tubulin, C-terminal domain | 0.1165 | INHERITED FROM: glossopharyngeal nerve || facial nerve || vagus nerve || trigeminal nerve |
| Actin/HSP70 | 0.127 | INHERITED FROM: head mesoderm || jaw muscle || head somite || cranial muscle |
| Protein kinases, catalytic subunit | 0.1514 | INHERITED FROM: head mesoderm |
| Homeodomain | 0.1655 | INHERITED FROM: medial septum || basal forebrain || midbrain-hindbrain boundary || bed nucleus of the stria terminalis || olfactory bulb || thalamus || lateral pallium || mandibular arch || cephalic nerve || ventricular zone || dorsal thalamus || amygdala || ventral pallium || retinal ganglion cell layer || septum || prosomere || neurocranium || eye || forebrain || mouth || cranium || retinal inner nuclear layer || ventral septum || prethalamus || lateral ganglionic eminence || hypothalamus || basal ganglion || telencephalon || rhombomere || hindbrain || medial ganglionic eminence || zona limitans intrathalamica || midbrain || pharyngeal arch || olfactory region || lateral septum || subpallium || preoptic area || anterior hypothalamus || periotic region || pineal gland || pallium || head mesenchyme || infundibulum || visceral pouch || pallidum || posterior hypothalamus || lower jaw || striatum || pharyngeal region || pretectum || diencephalon || optic stalk |
| T-box | 0.1722 | INHERITED FROM: pharyngeal arch || pharyngeal region |
| Hairy Orange domain | 0.207 | INHERITED FROM: eye || midbrain || pharyngeal region |
| LIM domain | 0.2337 | INHERITED FROM: basal forebrain || bed nucleus of the stria terminalis || central nucleus of the thalamus || thalamus || amygdala || septum || prosomere || ventrolateral thalamic nucleus || medial amygdala || ventral septum || prosomere 4 || anterior thalamic nucleus || pretectum |
| Tandem AAA-ATPase domain | 0.3706 | INHERITED FROM: forebrain || hindbrain || midbrain |
| Parvalbumin | 0.3728 | INHERITED FROM: cranial muscle |
| I set domains | 0.3841 | INHERITED FROM: pharyngeal mesenchyme || retinal ganglion cell layer || retinal inner nuclear layer |
| Myosin rod fragments | 0.3908 | INHERITED FROM: musculature of face |
| Sema domain | 0.4744 | INHERITED FROM: periocular region || midbrain-hindbrain boundary || branchial arch |
| L domain | 0.5226 | INHERITED FROM: pharyngeal region |
| Crystallins/Ca-binding development proteins | 0.6793 | INHERITED FROM: lens |
| Voltage-gated potassium channels | 0.6796 | INHERITED FROM: optic nerve || retinal inner plexiform layer || optic disc |
| Intermediate filament protein, coiled coil region | 0.7113 | INHERITED FROM: cephalic nerve || ventricular zone || retinal ganglion cell layer || retinal ganglion cell || retinal inner nuclear layer || vestibulocochlear nerve || optic nerve || midbrain tegmentum || retinal inner plexiform layer || medulla oblongata || nucleus reticularis inferior |
| Plexin repeat | 0.8001 | INHERITED FROM: periocular region || branchial arch |
| Fibronectin type III | 0.8286 | INHERITED FROM: retinal neural layer || retinal ganglion cell layer |
| POU-specific domain | 0.8407 | INHERITED FROM: retinal ganglion cell layer |
| Classic zinc finger, C2H2 | 0.8946 | INHERITED FROM: hindbrain || midbrain |
| Tetramerization domain of potassium channels | 0.9612 | INHERITED FROM: retinal outer plexiform layer || retinal ganglion cell layer || optic nerve || retinal inner plexiform layer || optic disc |
| Motor proteins | 0.987 | INHERITED FROM: musculature of face |
| Transforming growth factor (TGF)-beta | 1 | INHERITED FROM: head mesoderm || periocular region || branchial arch 3 || branchial arch 2 || branchial arch 1 || branchial arch 4 || head mesenchyme |
| Rhodopsin-like | 1 | INHERITED FROM: medial pallium || basal forebrain || amygdala || granule cell layer of the olfactory bulb || septum || hypothalamus || basal ganglion || preoptic area || anterior hypothalamus || pallium || eye photoreceptor cell || striatum || diencephalon |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Stathmin | 0 | Direct |
| Hedgehog (development protein), N-terminal signaling domain | 0 | Direct |
| Ferritin | 0 | Direct |
| Enolase N-terminal domain-like | 0 | Direct |
| Formin homology 2 domain (FH2 domain) | 0 | Direct |
| Trunk domain of Sec23/24 | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | Direct |
| PreBEACH PH-like domain | 0 | Direct |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | Direct |
| IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
| MIR domain | 0 | Direct |
| ARID domain | 0 | Direct |
| ENTH domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | Direct |
| LeuD-like | 0 | Direct |
| Pumilio repeat | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| APC10-like | 0 | Direct |
| Cation efflux protein transmembrane domain-like | 0 | Direct |
| Hook domain | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| eIF1-like | 0 | Direct |
| UDP-glucose pyrophosphorylase | 0 | Direct |
| I/LWEQ domain | 0 | Direct |
| Mib/herc2 domain | 0 | Direct |
| NTF2-like | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | Direct |
| Adenain-like | 0 | Direct |
| Cofactor-dependent phosphoglycerate mutase | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| TNF receptor-like | 0 | Direct |
| Glyoxalase II (hydroxyacylglutathione hydrolase) | 0 | Direct |
| FAS1 domain | 0 | Direct |
| PUA domain | 0 | Direct |
| Linker histone H1/H5 | 0 | Direct |
| E2F dimerization segment | 0 | Direct |
| alpha-mannosidase | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| HD domain | 0 | Direct |
| Cytochrome b5 | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| Cell cycle transcription factor e2f-dp | 0 | Direct |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
| Protein-L-isoaspartyl O-methyltransferase | 0 | Direct |
| GS domain | 0 | Direct |
| HCDH C-domain-like | 0 | Direct |
| Mannose 6-phosphate receptor domain | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| HAT/Suf repeat | 0 | Direct |
| Fumble-like | 0 | Direct |
| DNA gyrase/MutL, second domain | 0 | Direct |
| RUNT domain | 0 | Direct |
| CUE domain | 0 | Direct |
| DNA polymerase III clamp loader subunits, C-terminal domain | 0 | Direct |
| Prefoldin | 0 | Direct |
| gamma-adaptin C-terminal appendage domain-like | 0 | Direct |
| Guanido kinase catalytic domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| Globins | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Histone deacetylase, HDAC | 0 | Direct |
| Gonadodropin/Follitropin | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| TRASH domain | 0 | Direct |
| Plakin repeat | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| NIPSNAP | 0 | Direct |
| Cyclophilin (peptidylprolyl isomerase) | 0 | Direct |
| DNA ligase | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Glycosyl transferases group 1 | 0 | Direct |
| Paired domain | 0 | Direct |
| Pointed domain | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| Phenylalanine metabolism regulatory domain | 0 | Direct |
| MPP-like | 0 | Direct |
| Autophagin-like | 0 | Direct |
| Hect, E3 ligase catalytic domain | 0 | Direct |
| Histone lysine methyltransferases | 0 | Direct |
| Alpha-adaptin ear subdomain-like | 0 | Direct |
| CCHHC domain | 0 | Direct |
| IF2B-like | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| SRF-like | 0 | Direct |
| BC C-terminal domain-like | 0 | Direct |
| Notch domain | 0 | Direct |
| Acyl-CoA binding protein | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| SIAH, seven in absentia homolog | 0 | Direct |
| GABARAP-like | 0 | Direct |
| R3H domain | 0 | Direct |
| L30e/L7ae ribosomal proteins | 0 | Direct |
| Sedlin (SEDL) | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| RNA-polymerase beta-prime | 0 | Direct |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | Direct |
| ATP-dependent DNA ligase catalytic domain | 0 | Direct |
| Phoshatidylinositol transfer protein, PITP | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| MSP-like | 0 | Direct |
| DLC | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
| Chromo domain | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| Variant RING domain | 0 | Direct |
| alpha-mannosidase, domain 2 | 0 | Direct |
| Alanine racemase-like, N-terminal domain | 0 | Direct |
| Other IPT/TIG domains | 0 | Direct |
| RPR domain (SMART 00582 ) | 0 | Direct |
| Ephrin receptor ligand binding domain | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Transcriptional factor domain | 0 | Direct |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| USP8 N-terminal domain-like | 0 | Direct |
| SMAD domain | 0 | Direct |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0 | Direct |
| Arrestin/Vps26-like | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| ZZ domain | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | Direct |
| Homocysteine S-methyltransferase | 0 | Direct |
| LEM domain | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| DIX domain | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| MAST3 pre-PK domain-like | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| Noggin | 0 | Direct |
| Eukaryotic ODC-like | 0 | Direct |
| Tim10/DDP | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| NAP-like | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| Cyclin A/CDK2-associated p19, Skp2 | 0 | Direct |
| 4HBT-like | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Phosducin | 0 | Direct |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0 | Direct |
| alpha-mannosidase, C-terminal domain | 0 | Direct |
| Carboxylesterase/thioesterase 1 | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| PAH2 domain | 0 | Direct |
| alpha-catenin/vinculin | 0 | Direct |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | Direct |
| A20-like zinc finger | 0 | Direct |
| SCF ubiquitin ligase complex WHB domain | 0 | Direct |
| Domain G2 of nidogen-1 | 0 | Direct |
| Carboxylesterase | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | Direct |
| ECR1 N-terminal domain-like | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| P4 origin-binding domain-like | 0 | Direct |
| 1,3-glucuronyltransferase | 0 | Direct |
| Threonyl-tRNA synthetase (ThrRS), second 'additional' domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| BEACH domain | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| AAT-like | 0 | Direct |
| Chromo barrel domain | 0 | Direct |
| BSD domain | 0 | Direct |
| TRAPP components | 0 | Direct |
| Phosphoribosylpyrophosphate synthetase-like | 0 | Direct |
| Steroid-binding domain | 0 | Direct |
| Ran-binding domain | 0 | Direct |
| S-adenosylhomocystein hydrolase | 0 | Direct |
| DJ-1/PfpI | 0 | Direct |
| Transferrin | 0 | Direct |
| Kinase associated domain 1, KA1 | 0 | Direct |
| RhoGDI-like | 0 | Direct |
| Nop domain | 0 | Direct |
| DNA gyrase/MutL, N-terminal domain | 0 | Direct |
| Fibroblast growth factors (FGF) | 0 | Direct |
| SH3BGR (SH3-binding, glutamic acid-rich protein-like) | 0 | Direct |
| Synuclein | 0 | Direct |
| Cytidylyltransferase | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Ephrin ectodomain | 0 | Direct |
| a tRNA synthase domain | 0 | Direct |
| Cullin repeat | 0 | Direct |
| Polo-box duplicated region | 0 | Direct |
| RUN domain | 0 | Direct |
| Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| AraD-like aldolase/epimerase | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
| Arginine methyltransferase | 0 | Direct |
| GDI-like N domain | 0 | Direct |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | Direct |
| B56-like | 0 | Direct |
| HEAT repeat | 0 | Direct |
| FF domain | 0 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0.007389 | Inherited |
| Second domain of FERM | 0.01172 | Inherited |
| HMG-box | 0.01657 | Inherited |
| Canonical RBD | 0.02372 | Inherited |
| Forkhead DNA-binding domain | 0.03137 | Inherited |
| Frizzled cysteine-rich domain | 0.06981 | Inherited |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.0919 | Inherited |
| Glutathione peroxidase-like | 0.1102 | Inherited |
| ets domain | 0.1103 | Inherited |
| Tubulin, GTPase domain | 0.1165 | Inherited |
| Tubulin, C-terminal domain | 0.1165 | Inherited |
| Actin/HSP70 | 0.127 | Inherited |
| Protein kinases, catalytic subunit | 0.1514 | Inherited |
| Homeodomain | 0.1655 | Inherited |
| T-box | 0.1722 | Inherited |
| Hairy Orange domain | 0.207 | Inherited |
| LIM domain | 0.2337 | Inherited |
| Tandem AAA-ATPase domain | 0.3706 | Inherited |
| Parvalbumin | 0.3728 | Inherited |
| I set domains | 0.3841 | Inherited |
| Myosin rod fragments | 0.3908 | Inherited |
| Sema domain | 0.4744 | Inherited |
| L domain | 0.5226 | Inherited |
| Crystallins/Ca-binding development proteins | 0.6793 | Inherited |
| Voltage-gated potassium channels | 0.6796 | Inherited |
| Intermediate filament protein, coiled coil region | 0.7113 | Inherited |
| Plexin repeat | 0.8001 | Inherited |
| Fibronectin type III | 0.8286 | Inherited |
| POU-specific domain | 0.8407 | Inherited |
| Classic zinc finger, C2H2 | 0.8946 | Inherited |
| Tetramerization domain of potassium channels | 0.9612 | Inherited |
| Motor proteins | 0.987 | Inherited |
| Transforming growth factor (TGF)-beta | 1 | Inherited |
| Rhodopsin-like | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this XA term (Not in SPXA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Endosomal sorting complex assembly domain | 0 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| Cullin repeat-like | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| Acyl-CoA binding protein | 0 | DIRECT |
| Hedgehog/DD-peptidase | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Dimeric alpha+beta barrel | 0 | DIRECT |
| LuxS/MPP-like metallohydrolase | 0 | DIRECT |
| Hook domain | 0 | DIRECT |
| TNF receptor-like | 0 | DIRECT |
| Oligoxyloglucan reducing end-specific cellobiohydrolase | 0 | DIRECT |
| Actin-crosslinking proteins | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| Mediator hinge subcomplex-like | 0 | DIRECT |
| Globin-like | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| L30e-like | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| RNase III domain-like | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| Sialidases | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| Mss4-like | 0 | DIRECT |
| Enolase C-terminal domain-like | 0 | DIRECT |
| Chromo domain-like | 0 | DIRECT |
| alpha/beta knot | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| Mannose 6-phosphate receptor domain | 0 | DIRECT |
| MAST3 pre-PK domain-like | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Cytochrome b5-like heme/steroid binding domain | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Transducin (heterotrimeric G protein), gamma chain | 0 | DIRECT |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
| GINS helical bundle-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
| RUN domain-like | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| eIF1-like | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| GFP-like | 0 | DIRECT |
| S15/NS1 RNA-binding domain | 0 | DIRECT |
| E2F-DP heterodimerization region | 0 | DIRECT |
| USP8 N-terminal domain-like | 0 | DIRECT |
| DLC | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| I/LWEQ domain | 0 | DIRECT |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | DIRECT |
| Uracil-DNA glycosylase-like | 0 | DIRECT |
| ACT-like | 0 | DIRECT |
| post-AAA+ oligomerization domain-like | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| LEM domain | 0 | DIRECT |
| TGS-like | 0 | DIRECT |
| FAD-binding/transporter-associated domain-like | 0 | DIRECT |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
| ClpS-like | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| Di-copper centre-containing domain | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Ribosomal L27 protein-like | 0 | DIRECT |
| Transducin (alpha subunit), insertion domain | 0 | DIRECT |
| BSD domain-like | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| THUMP domain-like | 0 | DIRECT |
| Glycoside hydrolase/deacetylase | 0 | DIRECT |
| Stathmin | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | DIRECT |
| ThrRS/AlaRS common domain | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| NAP-like | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| KA1-like | 0 | DIRECT |
| Glutamine synthetase/guanido kinase | 0 | DIRECT |
| Sec1/munc18-like (SM) proteins | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| Homocysteine S-methyltransferase | 0 | DIRECT |
| Cyclophilin-like | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| Cysteine alpha-hairpin motif | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| Ligand-binding domain in the NO signalling and Golgi transport | 0 | DIRECT |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
| Sm-like ribonucleoproteins | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Mib/herc2 domain-like | 0 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
| Pentein | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| HRDC-like | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| AraD/HMP-PK domain-like | 0 | DIRECT |
| Enolase N-terminal domain-like | 0 | DIRECT |
| ACP-like | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| ARID-like | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| Prefoldin | 0 | DIRECT |
| PriA/YqbF domain | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Cytokine | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Ubiquitin-like | 0.0006438 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0.006476 | INHERITED FROM: eye || retinal stem cell region || periocular region || hyoid head muscle || cranial ganglion || olfactory region || cranium || pharyngeal region || forebrain || retinal ganglion cell layer || retinal outer nuclear layer || retinal inner plexiform layer || hindbrain || cranial muscle || m. interhyoideus || retinal inner nuclear layer || musculature of face || ventricular zone || head vasculature || photoreceptor layer || pharyngeal arch || midbrain |
| Second domain of FERM | 0.007631 | INHERITED FROM: cephalic nerve |
| HMG-box | 0.01505 | INHERITED FROM: midbrain-hindbrain boundary || splanchnocranium || pharyngeal region || forebrain || hindbrain || pharyngeal arch |
| RNA-binding domain, RBD | 0.02814 | INHERITED FROM: eye || pharyngeal region || forebrain || hindbrain || peripheral retina || pharyngeal arch |
| Frizzled cysteine-rich domain | 0.06607 | INHERITED FROM: eye || cranial ganglion || midbrain-hindbrain boundary || pharyngeal region || forebrain || hindbrain || pharyngeal arch || midbrain |
| "Winged helix" DNA-binding domain | 0.07428 | INHERITED FROM: eye || periocular region || head mesoderm || visceral pouch || pharyngeal region || pharyngeal arch |
| Homeodomain-like | 0.08454 | INHERITED FROM: diencephalon || ventral pallium || eye || prethalamus || anterior hypothalamus || lateral pallium || cephalic nerve || posterior hypothalamus || mouth || dorsal thalamus || prosomere || striatum || subpallium || retinal pigmented epithelium || rhombomere || lower jaw || neurocranium || septum || infundibulum || olfactory region || pretectum || midbrain-hindbrain boundary || optic stalk || pallium || cranium || pharyngeal endoderm || visceral pouch || pharyngeal region || basal ganglion || forebrain || retinal ganglion cell layer || lateral septum || ventral septum || optic tract || hindbrain || retinal inner nuclear layer || ventricular zone || pallidum || telencephalon || periotic region || amygdala || preoptic area || medial septum || head mesenchyme || medial ganglionic eminence || thalamus || hypothalamus || pharyngeal pouch || zona limitans intrathalamica || lateral ganglionic eminence || basal forebrain || pharyngeal arch || olfactory bulb || midbrain |
| Tubulin C-terminal domain-like | 0.1121 | INHERITED FROM: vagus nerve || glossopharyngeal nerve || facial nerve || trigeminal nerve |
| Phosphoglycerate mutase-like | 0.1434 | INHERITED FROM: head mesenchyme |
| Protein kinase-like (PK-like) | 0.1471 | INHERITED FROM: head mesoderm || pharyngeal region |
| Snake toxin-like | 0.1663 | INHERITED FROM: head mesoderm || head mesenchyme |
| PYP-like sensor domain (PAS domain) | 0.1968 | INHERITED FROM: eye |
| Orange domain-like | 0.2016 | INHERITED FROM: eye || pharyngeal region || midbrain |
| Ras GEF | 0.2467 | INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer |
| Tubulin nucleotide-binding domain-like | 0.2761 | INHERITED FROM: vagus nerve || glossopharyngeal nerve || facial nerve || trigeminal nerve |
| PH domain-like | 0.301 | INHERITED FROM: brain |
| p53-like transcription factors | 0.3767 | INHERITED FROM: eye || Meckel's cartilage || lower jaw || facial nerve || branchial arch skeleton || pharyngeal region || chondrocranium || ceratohyal || pharyngeal arch |
| SET domain | 0.4531 | INHERITED FROM: hindbrain |
| Voltage-gated potassium channels | 0.5416 | INHERITED FROM: optic disc || retinal neural layer || cephalic nerve || optic nerve || retinal ganglion cell layer || retinal inner plexiform layer |
| Myosin rod fragments | 0.5673 | INHERITED FROM: musculature of face |
| Sema domain | 0.5934 | INHERITED FROM: periocular region || branchial arch |
| gamma-Crystallin-like | 0.6731 | INHERITED FROM: lens |
| P-domain of calnexin/calreticulin | 0.6753 | INHERITED FROM: pharyngeal arch |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.6854 | INHERITED FROM: diencephalon || ventral pallium || anterior hypothalamus || lateral pallium || prosomere || striatum || prosomere 4 || subpallium || septum || central nucleus of the thalamus || pretectum || optic tectum || basal ganglion || forebrain || lateral septum || ventral septum || hindbrain || amygdala || preoptic area || medial septum || ventrolateral thalamic nucleus || thalamus || hypothalamus || zona limitans intrathalamica || basal forebrain || midbrain |
| Intermediate filament protein, coiled coil region | 0.7028 | INHERITED FROM: retinal neural layer || cephalic nerve || midbrain tegmentum || retinal ganglion cell || optic nerve || nucleus reticularis inferior || vestibulocochlear nerve || retinal ganglion cell layer || retinal inner plexiform layer || retinal inner nuclear layer || ventricular zone || medulla oblongata |
| Galactose-binding domain-like | 0.7476 | INHERITED FROM: optic nerve |
| Plexin repeat | 0.7888 | INHERITED FROM: periocular region || branchial arch |
| Actin-like ATPase domain | 0.7938 | INHERITED FROM: head somite || jaw muscle || cranial muscle |
| Fibronectin type III | 0.8651 | INHERITED FROM: retinal neural layer || retinal ganglion cell layer || retinal inner nuclear layer |
| Cystine-knot cytokines | 1 | INHERITED FROM: periocular region || head mesoderm || branchial arch 3 || branchial arch 2 || head mesenchyme || pharyngeal arch |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: diencephalon || anterior hypothalamus || striatum || septum || pallium || granule cell layer of the olfactory bulb || basal ganglion || amygdala || preoptic area || medial pallium || hypothalamus || basal forebrain |
| Immunoglobulin | 1 | INHERITED FROM: retinal inner nuclear layer |
| POZ domain | 1 | INHERITED FROM: optic disc |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Endosomal sorting complex assembly domain | 0 | Direct |
| Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| Cullin repeat-like | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| NTF2-like | 0 | Direct |
| Acyl-CoA binding protein | 0 | Direct |
| Hedgehog/DD-peptidase | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Dimeric alpha+beta barrel | 0 | Direct |
| LuxS/MPP-like metallohydrolase | 0 | Direct |
| Hook domain | 0 | Direct |
| TNF receptor-like | 0 | Direct |
| Oligoxyloglucan reducing end-specific cellobiohydrolase | 0 | Direct |
| Actin-crosslinking proteins | 0 | Direct |
| Nop domain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| Mediator hinge subcomplex-like | 0 | Direct |
| Globin-like | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Polo-box domain | 0 | Direct |
| L30e-like | 0 | Direct |
| Synuclein | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| RNase III domain-like | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| Sialidases | 0 | Direct |
| FF domain | 0 | Direct |
| Mss4-like | 0 | Direct |
| Enolase C-terminal domain-like | 0 | Direct |
| Chromo domain-like | 0 | Direct |
| alpha/beta knot | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| Mannose 6-phosphate receptor domain | 0 | Direct |
| MAST3 pre-PK domain-like | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| Myosin phosphatase inhibitor 17kDa protein, CPI-17 | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Cytochrome b5-like heme/steroid binding domain | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| LeuD/IlvD-like | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Transducin (heterotrimeric G protein), gamma chain | 0 | Direct |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
| GINS helical bundle-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| GYF domain | 0 | Direct |
| ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
| RUN domain-like | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| eIF1-like | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| GFP-like | 0 | Direct |
| S15/NS1 RNA-binding domain | 0 | Direct |
| E2F-DP heterodimerization region | 0 | Direct |
| USP8 N-terminal domain-like | 0 | Direct |
| DLC | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| I/LWEQ domain | 0 | Direct |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | Direct |
| Uracil-DNA glycosylase-like | 0 | Direct |
| ACT-like | 0 | Direct |
| post-AAA+ oligomerization domain-like | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| LEM domain | 0 | Direct |
| TGS-like | 0 | Direct |
| FAD-binding/transporter-associated domain-like | 0 | Direct |
| Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
| CCHHC domain | 0 | Direct |
| Families 57/38 glycoside transferase middle domain | 0 | Direct |
| ClpS-like | 0 | Direct |
| GroEL-intermediate domain like | 0 | Direct |
| FAS1 domain | 0 | Direct |
| Di-copper centre-containing domain | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Ribosomal L27 protein-like | 0 | Direct |
| Transducin (alpha subunit), insertion domain | 0 | Direct |
| BSD domain-like | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| THUMP domain-like | 0 | Direct |
| Glycoside hydrolase/deacetylase | 0 | Direct |
| Stathmin | 0 | Direct |
| SRF-like | 0 | Direct |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | Direct |
| ThrRS/AlaRS common domain | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| NAP-like | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| Plakin repeat | 0 | Direct |
| KA1-like | 0 | Direct |
| Glutamine synthetase/guanido kinase | 0 | Direct |
| Sec1/munc18-like (SM) proteins | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| Homocysteine S-methyltransferase | 0 | Direct |
| Cyclophilin-like | 0 | Direct |
| PAH2 domain | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| BEACH domain | 0 | Direct |
| Tim10-like | 0 | Direct |
| Cysteine alpha-hairpin motif | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| Ligand-binding domain in the NO signalling and Golgi transport | 0 | Direct |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
| Sm-like ribonucleoproteins | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Mib/herc2 domain-like | 0 | Direct |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
| Pentein | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| HRDC-like | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| AraD/HMP-PK domain-like | 0 | Direct |
| Enolase N-terminal domain-like | 0 | Direct |
| ACP-like | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| ARID-like | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| Prefoldin | 0 | Direct |
| PriA/YqbF domain | 0 | Direct |
| Notch domain | 0 | Direct |
| Cytokine | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
| MIR domain | 0 | Direct |
| Ubiquitin-like | 0.0006438 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0.006476 | Inherited |
| Second domain of FERM | 0.007631 | Inherited |
| HMG-box | 0.01505 | Inherited |
| RNA-binding domain, RBD | 0.02814 | Inherited |
| Frizzled cysteine-rich domain | 0.06607 | Inherited |
| "Winged helix" DNA-binding domain | 0.07428 | Inherited |
| Homeodomain-like | 0.08454 | Inherited |
| Tubulin C-terminal domain-like | 0.1121 | Inherited |
| Phosphoglycerate mutase-like | 0.1434 | Inherited |
| Protein kinase-like (PK-like) | 0.1471 | Inherited |
| Snake toxin-like | 0.1663 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.1968 | Inherited |
| Orange domain-like | 0.2016 | Inherited |
| Ras GEF | 0.2467 | Inherited |
| Tubulin nucleotide-binding domain-like | 0.2761 | Inherited |
| PH domain-like | 0.301 | Inherited |
| p53-like transcription factors | 0.3767 | Inherited |
| SET domain | 0.4531 | Inherited |
| Voltage-gated potassium channels | 0.5416 | Inherited |
| Myosin rod fragments | 0.5673 | Inherited |
| Sema domain | 0.5934 | Inherited |
| gamma-Crystallin-like | 0.6731 | Inherited |
| P-domain of calnexin/calreticulin | 0.6753 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.6854 | Inherited |
| Intermediate filament protein, coiled coil region | 0.7028 | Inherited |
| Galactose-binding domain-like | 0.7476 | Inherited |
| Plexin repeat | 0.7888 | Inherited |
| Actin-like ATPase domain | 0.7938 | Inherited |
| Fibronectin type III | 0.8651 | Inherited |
| Cystine-knot cytokines | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
| Immunoglobulin | 1 | Inherited |
| POZ domain | 1 | Inherited |
(show details)
Supra-domains annotated to this XA term (Not in SPXA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
82109,82109
82109 - MIR domain
82109 - MIR domain | 0 | DIRECT |
50998,50978
50998 - Quinoprotein alcohol dehydrogenase-like
50978 - WD40 repeat-like | 0 | DIRECT |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | DIRECT |
57184,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
88723,47807
88723 - PIN domain-like
47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
54534,47473
54534 - FKBP-like
47473 - EF-hand | 0 | DIRECT |
57196,100895
57196 - EGF/Laminin
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | DIRECT |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | DIRECT |
110324,50249
110324 - Ribosomal L27 protein-like
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
54511,57184
54511 - GFP-like
57184 - Growth factor receptor domain | 0 | DIRECT |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | DIRECT |
47473,57889
47473 - EF-hand
57889 - Cysteine-rich domain | 0 | DIRECT |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | DIRECT |
49313,49899
49313 - Cadherin-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | DIRECT |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | DIRECT |
51045,56204
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 0 | DIRECT |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
50044,48350
50044 - SH3-domain
48350 - GTPase activation domain, GAP | 0 | DIRECT |
100895,47473
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand | 0 | DIRECT |
101288,50156
101288 - L27 domain
50156 - PDZ domain-like | 0 | DIRECT |
57535,49854
57535 - Complement control module/SCR domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | DIRECT |
56112,48371
56112 - Protein kinase-like (PK-like)
48371 - ARM repeat | 0 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | DIRECT |
57196,56436
57196 - EGF/Laminin
56436 - C-type lectin-like | 0 | DIRECT |
49562,53300
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
53300 - vWA-like | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0 | DIRECT |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | DIRECT |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | DIRECT |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
56491,89811
56491 - A heparin-binding domain
89811 - Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
64356,49447
64356 - SNARE-like
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | DIRECT |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | DIRECT |
56436,57535
56436 - C-type lectin-like
57535 - Complement control module/SCR domain | 0 | DIRECT |
57184,49265
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | DIRECT |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
48065,103657
48065 - DBL homology domain (DH-domain)
103657 - BAR/IMD domain-like | 0 | DIRECT |
50729,57889
50729 - PH domain-like
57889 - Cysteine-rich domain | 0 | DIRECT |
81995,81811
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | DIRECT |
52096,52096
52096 - ClpP/crotonase
52096 - ClpP/crotonase | 0 | DIRECT |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | DIRECT |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0 | DIRECT |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | DIRECT |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
53300,81995
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0 | DIRECT |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
47095,47095
47095 - HMG-box
47095 - HMG-box | 0 | DIRECT |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0 | DIRECT |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0 | DIRECT |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
48034,55931
48034 - Guanido kinase N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0 | DIRECT |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0 | DIRECT |
49899,48726
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin | 0 | DIRECT |
50729,81837
50729 - PH domain-like
81837 - BEACH domain | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
48403,52540
48403 - Ankyrin repeat
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
47473,57850
47473 - EF-hand
57850 - RING/U-box | 0 | DIRECT |
48403,50044
48403 - Ankyrin repeat
50044 - SH3-domain | 0 | DIRECT |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
50044,50156
50044 - SH3-domain
50156 - PDZ domain-like | 0 | DIRECT |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | DIRECT |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
54236,48366
54236 - Ubiquitin-like
48366 - Ras GEF | 0 | DIRECT |
81271,55186
81271 - TGS-like
55186 - ThrRS/AlaRS common domain | 0 | DIRECT |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
46942,57783
46942 - Elongation factor TFIIS domain 2
57783 - Zinc beta-ribbon | 0 | DIRECT |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
48371,46785
48371 - ARM repeat
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
69065,54768
69065 - RNase III domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
51045,50156
51045 - WW domain
50156 - PDZ domain-like | 0 | DIRECT |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
54160,57850
54160 - Chromo domain-like
57850 - RING/U-box | 0 | DIRECT |
88713,88688
88713 - Glycoside hydrolase/deacetylase
88688 - Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
47370,47370
47370 - Bromodomain
47370 - Bromodomain | 0 | DIRECT |
55486,48371
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | DIRECT |
46565,57938
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
82109,100909
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | DIRECT |
103657,50044
103657 - BAR/IMD domain-like
50044 - SH3-domain | 0 | DIRECT |
57184,100895
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | DIRECT |
64268,103657
64268 - PX domain
103657 - BAR/IMD domain-like | 0 | DIRECT |
48350,50729
48350 - GTPase activation domain, GAP
50729 - PH domain-like | 0 | DIRECT |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0 | DIRECT |
52540,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain | 0 | DIRECT |
82153,82153
82153 - FAS1 domain
82153 - FAS1 domain | 0 | DIRECT |
48726,56436
48726 - Immunoglobulin
56436 - C-type lectin-like | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | DIRECT |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
117281,50965
117281 - Kelch motif
50965 - Galactose oxidase, central domain | 0 | DIRECT |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | DIRECT |
103637,103637
103637 - CCHHC domain
103637 - CCHHC domain | 0 | DIRECT |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.01111 | INHERITED FROM: pharyngeal region || pharyngeal arch |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.1121 | INHERITED FROM: vagus nerve || glossopharyngeal nerve || facial nerve || trigeminal nerve |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.1663 | INHERITED FROM: eye |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.2016 | INHERITED FROM: eye || pharyngeal region || midbrain |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.222 | INHERITED FROM: retinal neural layer || retinal ganglion cell layer || retinal inner nuclear layer |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.2664 | INHERITED FROM: ventral pallium || anterior hypothalamus || lateral pallium || cephalic nerve || medial amygdala || prosomere || striatum || prosomere 4 || subpallium || septum || central nucleus of the thalamus || pretectum || pallium || cranium || optic tectum || basal ganglion || bed nucleus of the stria terminalis || forebrain || anterior thalamic nucleus || lateral septum || ventral septum || hindbrain || amygdala || preoptic area || medial septum || ventrolateral thalamic nucleus || thalamus || hypothalamus || zona limitans intrathalamica || basal forebrain |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0.3537 | INHERITED FROM: retinal neural layer || retinal ganglion cell layer || retinal inner nuclear layer |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.392 | INHERITED FROM: musculature of face |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0.4511 | INHERITED FROM: midbrain-hindbrain boundary |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.516 | INHERITED FROM: pharyngeal region |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.516 | INHERITED FROM: pharyngeal region |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.5907 | INHERITED FROM: pharyngeal region |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.5934 | INHERITED FROM: periocular region || branchial arch |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.6049 | INHERITED FROM: head somite || jaw muscle || cranial muscle |
49899,63887
49899 - Concanavalin A-like lectins/glucanases
63887 - P-domain of calnexin/calreticulin | 0.6753 | INHERITED FROM: pharyngeal arch |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0.726 | INHERITED FROM: retinal ganglion cell layer |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.7976 | INHERITED FROM: otic region || hindbrain |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.8357 | INHERITED FROM: hypothalamus |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.8733 | INHERITED FROM: head vasculature |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.9435 | INHERITED FROM: retinal inner nuclear layer |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
82109,82109
82109 - MIR domain
82109 - MIR domain | 0 | Direct |
50998,50978
50998 - Quinoprotein alcohol dehydrogenase-like
50978 - WD40 repeat-like | 0 | Direct |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | Direct |
57184,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
88723,47807
88723 - PIN domain-like
47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
54534,47473
54534 - FKBP-like
47473 - EF-hand | 0 | Direct |
57196,100895
57196 - EGF/Laminin
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | Direct |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | Direct |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | Direct |
110324,50249
110324 - Ribosomal L27 protein-like
50249 - Nucleic acid-binding proteins | 0 | Direct |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
54511,57184
54511 - GFP-like
57184 - Growth factor receptor domain | 0 | Direct |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | Direct |
47473,57889
47473 - EF-hand
57889 - Cysteine-rich domain | 0 | Direct |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | Direct |
49313,49899
49313 - Cadherin-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | Direct |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | Direct |
51045,56204
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 0 | Direct |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0 | Direct |
50044,48350
50044 - SH3-domain
48350 - GTPase activation domain, GAP | 0 | Direct |
100895,47473
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand | 0 | Direct |
101288,50156
101288 - L27 domain
50156 - PDZ domain-like | 0 | Direct |
57535,49854
57535 - Complement control module/SCR domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | Direct |
56112,48371
56112 - Protein kinase-like (PK-like)
48371 - ARM repeat | 0 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | Direct |
57196,56436
57196 - EGF/Laminin
56436 - C-type lectin-like | 0 | Direct |
49562,53300
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
53300 - vWA-like | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0 | Direct |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 0 | Direct |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | Direct |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | Direct |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
56491,89811
56491 - A heparin-binding domain
89811 - Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
64356,49447
64356 - SNARE-like
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | Direct |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | Direct |
56436,57535
56436 - C-type lectin-like
57535 - Complement control module/SCR domain | 0 | Direct |
57184,49265
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | Direct |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
48065,103657
48065 - DBL homology domain (DH-domain)
103657 - BAR/IMD domain-like | 0 | Direct |
50729,57889
50729 - PH domain-like
57889 - Cysteine-rich domain | 0 | Direct |
81995,81811
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | Direct |
52096,52096
52096 - ClpP/crotonase
52096 - ClpP/crotonase | 0 | Direct |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | Direct |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0 | Direct |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | Direct |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
53300,81995
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0 | Direct |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | Direct |
75632,46785
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
47095,47095
47095 - HMG-box
47095 - HMG-box | 0 | Direct |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0 | Direct |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0 | Direct |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
48034,55931
48034 - Guanido kinase N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0 | Direct |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0 | Direct |
49899,48726
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin | 0 | Direct |
50729,81837
50729 - PH domain-like
81837 - BEACH domain | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
48403,52540
48403 - Ankyrin repeat
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
47473,57850
47473 - EF-hand
57850 - RING/U-box | 0 | Direct |
48403,50044
48403 - Ankyrin repeat
50044 - SH3-domain | 0 | Direct |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
50044,50156
50044 - SH3-domain
50156 - PDZ domain-like | 0 | Direct |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | Direct |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
54236,48366
54236 - Ubiquitin-like
48366 - Ras GEF | 0 | Direct |
81271,55186
81271 - TGS-like
55186 - ThrRS/AlaRS common domain | 0 | Direct |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
46942,57783
46942 - Elongation factor TFIIS domain 2
57783 - Zinc beta-ribbon | 0 | Direct |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
48371,46785
48371 - ARM repeat
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
69065,54768
69065 - RNase III domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | Direct |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | Direct |
51045,50156
51045 - WW domain
50156 - PDZ domain-like | 0 | Direct |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
54160,57850
54160 - Chromo domain-like
57850 - RING/U-box | 0 | Direct |
88713,88688
88713 - Glycoside hydrolase/deacetylase
88688 - Families 57/38 glycoside transferase middle domain | 0 | Direct |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
47370,47370
47370 - Bromodomain
47370 - Bromodomain | 0 | Direct |
55486,48371
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | Direct |
46565,57938
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
82109,100909
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | Direct |
103657,50044
103657 - BAR/IMD domain-like
50044 - SH3-domain | 0 | Direct |
57184,100895
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | Direct |
64268,103657
64268 - PX domain
103657 - BAR/IMD domain-like | 0 | Direct |
48350,50729
48350 - GTPase activation domain, GAP
50729 - PH domain-like | 0 | Direct |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0 | Direct |
52540,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain | 0 | Direct |
82153,82153
82153 - FAS1 domain
82153 - FAS1 domain | 0 | Direct |
48726,56436
48726 - Immunoglobulin
56436 - C-type lectin-like | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | Direct |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
117281,50965
117281 - Kelch motif
50965 - Galactose oxidase, central domain | 0 | Direct |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | Direct |
103637,103637
103637 - CCHHC domain
103637 - CCHHC domain | 0 | Direct |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.01111 | Inherited |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.1121 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.1663 | Inherited |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.2016 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.222 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.2664 | Inherited |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0.3537 | Inherited |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.392 | Inherited |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0.4511 | Inherited |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.516 | Inherited |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.516 | Inherited |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.5907 | Inherited |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.5934 | Inherited |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.6049 | Inherited |
49899,63887
49899 - Concanavalin A-like lectins/glucanases
63887 - P-domain of calnexin/calreticulin | 0.6753 | Inherited |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0.726 | Inherited |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.7976 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.8357 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.8733 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.9435 | Inherited |
(show details)
Supra-domains annotated to this XA term (Not in SPXA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
49854,57535,57535
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
49899,57196,49899
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
63737,55486,48371
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | DIRECT |
57196,57196,49899
57196 - EGF/Laminin
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
53300,81995,81811
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | DIRECT |
103657,50729,48350
103657 - BAR/IMD domain-like
50729 - PH domain-like
48350 - GTPase activation domain, GAP | 0 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
49899,57196,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
54768,54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
46565,57938,49493
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
103647,103647,49899
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
103637,103637,103637
103637 - CCHHC domain
103637 - CCHHC domain
103637 - CCHHC domain | 0 | DIRECT |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
81995,81811,82754
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
52058,52058,52058
52058 - L domain-like
52058 - L domain-like
52058 - L domain-like | 0 | DIRECT |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
57535,49854,57535
57535 - Complement control module/SCR domain
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
51045,51045,56204
51045 - WW domain
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 0 | DIRECT |
47220,47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
47769,47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | DIRECT |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
48726,56436,56436
48726 - Immunoglobulin
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | DIRECT |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54160,57850,57845
54160 - Chromo domain-like
57850 - RING/U-box
57845 - B-box zinc-binding domain | 0 | DIRECT |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
49899,48726,49265
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | DIRECT |
48065,103657,50044
48065 - DBL homology domain (DH-domain)
103657 - BAR/IMD domain-like
50044 - SH3-domain | 0 | DIRECT |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
52540,51045,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain
51045 - WW domain | 0 | DIRECT |
49313,49313,49899
49313 - Cadherin-like
49313 - Cadherin-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
82109,82109,100909
82109 - MIR domain
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
103647,103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | DIRECT |
49562,49562,53300
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
53300 - vWA-like | 0 | DIRECT |
57196,49899,57196
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0 | DIRECT |
54511,57184,57184
54511 - GFP-like
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
101288,50156,50044
101288 - L27 domain
50156 - PDZ domain-like
50044 - SH3-domain | 0 | DIRECT |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.1233 | INHERITED FROM: retinal ganglion cell layer || hindbrain || retinal inner nuclear layer |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0.2464 | INHERITED FROM: pharyngeal region |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.3419 | INHERITED FROM: eye |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0.4511 | INHERITED FROM: midbrain-hindbrain boundary |
90257,90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.516 | INHERITED FROM: branchial arch |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.5907 | INHERITED FROM: pharyngeal region |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.6731 | INHERITED FROM: eye || pharyngeal region || forebrain || branchial arch |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.8669 | INHERITED FROM: pharyngeal mesenchyme |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | Direct |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
49854,57535,57535
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
49899,57196,49899
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
63737,55486,48371
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | Direct |
57196,57196,49899
57196 - EGF/Laminin
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
53300,81995,81811
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | Direct |
103657,50729,48350
103657 - BAR/IMD domain-like
50729 - PH domain-like
48350 - GTPase activation domain, GAP | 0 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
49899,57196,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
54768,54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
46565,57938,49493
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
103647,103647,49899
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
103637,103637,103637
103637 - CCHHC domain
103637 - CCHHC domain
103637 - CCHHC domain | 0 | Direct |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
81995,81811,82754
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
52058,52058,52058
52058 - L domain-like
52058 - L domain-like
52058 - L domain-like | 0 | Direct |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
57535,49854,57535
57535 - Complement control module/SCR domain
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0 | Direct |
51045,51045,56204
51045 - WW domain
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 0 | Direct |
47220,47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
47769,47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | Direct |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
48726,56436,56436
48726 - Immunoglobulin
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | Direct |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54160,57850,57845
54160 - Chromo domain-like
57850 - RING/U-box
57845 - B-box zinc-binding domain | 0 | Direct |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
49899,48726,49265
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | Direct |
48065,103657,50044
48065 - DBL homology domain (DH-domain)
103657 - BAR/IMD domain-like
50044 - SH3-domain | 0 | Direct |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
52540,51045,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain
51045 - WW domain | 0 | Direct |
49313,49313,49899
49313 - Cadherin-like
49313 - Cadherin-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
82109,82109,100909
82109 - MIR domain
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
103647,103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | Direct |
49562,49562,53300
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
53300 - vWA-like | 0 | Direct |
57196,49899,57196
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0 | Direct |
54511,57184,57184
54511 - GFP-like
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
101288,50156,50044
101288 - L27 domain
50156 - PDZ domain-like
50044 - SH3-domain | 0 | Direct |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.1233 | Inherited |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0.2464 | Inherited |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.3419 | Inherited |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0.4511 | Inherited |
90257,90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.516 | Inherited |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.5907 | Inherited |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.6731 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.8669 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
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