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Xenopus ANatomical entity (XAN): embryo
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: XA Hierarchy (Xenopus anatomy and development from Xenbase frog anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this XA term (SDXA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Nucleoplasmin-like core domain | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| C-terminal domain of adenylylcyclase associated protein | 0 | DIRECT |
| Translation proteins SH3-like domain | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0 | DIRECT |
| E2F-DP heterodimerization region | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Eferin C-derminal domain-like | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| GINS helical bundle-like | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Mib/herc2 domain-like | 0 | DIRECT |
| PriA/YqbF domain | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| Trefoil | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Sm-like ribonucleoproteins | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| Ribonuclease PH domain 2-like | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| PAP/OAS1 substrate-binding domain | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Soluble quinoprotein glucose dehydrogenase | 0 | DIRECT |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| BSD domain-like | 0 | DIRECT |
| Uracil-DNA glycosylase-like | 0 | DIRECT |
| Hedgehog/DD-peptidase | 0 | DIRECT |
| ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| DLC | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Ribosomal proteins L15p and L18e | 0 | DIRECT |
| LuxS/MPP-like metallohydrolase | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Cytokine | 0 | DIRECT |
| Ribosomal L27 protein-like | 0 | DIRECT |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| PEBP-like | 0 | DIRECT |
| RNA-binding domain, RBD | 0.00000000000009245 | DIRECT |
| Homeodomain-like | 0.000000000001064 | DIRECT |
| "Winged helix" DNA-binding domain | 0.000000007781 | DIRECT |
| Nucleic acid-binding proteins | 0.000004193 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0.000005429 | DIRECT |
| Bromodomain | 0.0000946 | DIRECT |
| SAP domain | 0.0008311 | DIRECT |
| SET domain | 0.001427 | INHERITED FROM: primary germ layer |
| HMG-box | 0.004327 | INHERITED FROM: embryonic structure || mandibular crest || neural plate border || neural plate || lower blastopore lip || pre-chordal neural plate || neurogenic placode || optic field || cranial neural crest || neuroectoderm || posterior branchial crest || retinal layer || endocardial tube || anterior neural fold || endoderm || neuroectoderm outer layer || neural fold || neural crest || chordal neural plate || anterior branchial crest || midbrain-hindbrain boundary || hyoid crest |
| Transducin (alpha subunit), insertion domain | 0.005816 | INHERITED FROM: dorsal marginal zone || pronephric kidney || coelom || animal hemisphere |
| Cyclin-like | 0.009607 | INHERITED FROM: animal pole || postmigratory neural crest cell |
| CCCH zinc finger | 0.00968 | INHERITED FROM: animal pole |
| Frizzled cysteine-rich domain | 0.01439 | INHERITED FROM: embryonic structure || optic vesicle || mouth primordium || tail tip || neural plate || pre-chordal neural plate || liver primordium || stomodeal-hypophyseal primordium || stomach || optic field || neural tube || neuroectoderm || primordium || cardiac mesoderm || axial mesoderm || coelom || anterior neural fold || endoderm || presumptive paraxial mesoderm || lateral plate mesoderm || tail fin || mesoderm || somite || neural fold || involuted dorsal mesoderm || gall bladder || prechordal plate || presomitic mesoderm || midbrain-hindbrain boundary || foregut |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.02407 | INHERITED FROM: embryonic structure || cranial placode || liver diverticulum || neuroectoderm || anterior placodal area || archenteron floor || preplacodal ectoderm || sensorial layer of neurectoderm || proximal tubule branch |
| GroEL-intermediate domain like | 0.03685 | INHERITED FROM: anterior dorsal lateral plate region || endomesoderm |
| GroEL equatorial domain-like | 0.03685 | INHERITED FROM: anterior dorsal lateral plate region || endomesoderm |
| Thioredoxin-like | 0.06617 | INHERITED FROM: early proximal tubule |
| Tubulin C-terminal domain-like | 0.07151 | INHERITED FROM: vegetal hemisphere || epidermal cell || epidermis || gastrocoel roof plate || non-neural ectoderm |
| ARID-like | 0.09156 | INHERITED FROM: pronephric tubule |
| Snake toxin-like | 0.1129 | INHERITED FROM: neural plate || pre-chordal neural plate || ventral mesoderm || neuroectoderm || lateral plate mesoderm || animal hemisphere || mesoderm || involuted dorsal mesoderm || head mesoderm || chordal neural plate |
| Actin-like ATPase domain | 0.1187 | INHERITED FROM: head somite |
| GroEL apical domain-like | 0.128 | INHERITED FROM: anterior dorsal lateral plate region |
| Alpha-macroglobulin receptor domain | 0.13 | INHERITED FROM: hindgut || midgut || archenteron || foregut |
| Tubulin nucleotide-binding domain-like | 0.1348 | INHERITED FROM: vegetal hemisphere || epidermal cell || epidermis || gastrocoel roof plate || non-neural ectoderm |
| Cystine-knot cytokines | 0.1355 | INHERITED FROM: embryonic structure || bottle cell || mouth primordium || vegetal hemisphere || involuting marginal zone || involuting marginal zone mesenchymal layer || neurogenic placode || dorsal marginal zone || ventral mesoderm || neural tube || neuroectoderm || circumblastoporal collar || axial mesoderm || vegetal endoderm || early embryonic cell || endoderm || neural groove || animal hemisphere || mesoderm || involuted dorsal mesoderm || head mesoderm || prechordal plate |
| lambda repressor-like DNA-binding domains | 0.1722 | INHERITED FROM: early distal tubule || presumptive midbrain-hindbrain boundary || neural plate || cranial placode || neurogenic placode || neural tube || neuroectoderm || distal tubule || pronephric tubule || late distal tubule || neural fold || proximal tubule || chordal neural plate |
| Orange domain-like | 0.1775 | INHERITED FROM: fin || chordoneural hinge || tail tip || cranial placode || pre-chordal neural plate || neural tube || neuroectoderm || coelom || anterior neural fold || lateral plate mesoderm || neural groove || intermediate mesoderm || paraxial mesoderm || mesoderm || neural fold || presomitic mesoderm |
| Sema domain | 0.2189 | INHERITED FROM: embryonic structure || presumptive midbrain-hindbrain boundary || cranial placode || otic placode || cranial neural crest || neuroectoderm || involuted dorsal mesoderm || neural crest |
| Protein kinase-like (PK-like) | 0.2305 | INHERITED FROM: animal hemisphere || head mesoderm |
| Mannose 6-phosphate receptor domain | 0.2425 | INHERITED FROM: cement gland primordium |
| p53-like transcription factors | 0.2751 | INHERITED FROM: neural plate || cranial placode || lower blastopore lip || neurogenic placode || neuroectoderm || lung primordium || mesoderm || lung bud || foregut || involuted ventral mesoderm |
| Intermediate filament protein, coiled coil region | 0.2751 | INHERITED FROM: epidermis |
| Troponin coil-coiled subunits | 0.3251 | INHERITED FROM: mesoderm |
| TIMP-like | 0.3314 | INHERITED FROM: pre-chordal neural plate || stomodeal-hypophyseal primordium || optic field || endoderm || prechordal plate || foregut |
| Clavaminate synthase-like | 0.3995 | INHERITED FROM: late proximal tubule || late distal tubule |
| Terpenoid cyclases/Protein prenyltransferases | 0.414 | INHERITED FROM: hindgut || midgut |
| F-box domain | 0.4164 | INHERITED FROM: animal hemisphere |
| PYP-like sensor domain (PAS domain) | 0.4919 | INHERITED FROM: mesoderm || somite |
| Subtilisin-like | 0.5053 | INHERITED FROM: vegetal hemisphere |
| beta-beta-alpha zinc fingers | 0.5657 | INHERITED FROM: chordal neural plate border || pre-chordal neural plate || presumptive rhombomere || anterior neural ridge || splanchnic layer of lateral plate mesoderm || neural fold || chordal neural plate || pre-chordal neural plate border |
| Plexin repeat | 0.5861 | INHERITED FROM: presumptive midbrain-hindbrain boundary || cranial placode || liver primordium || otic placode || cranial neural crest || neuroectoderm || involuted dorsal mesoderm || neural crest |
| Kringle-like | 0.5905 | INHERITED FROM: neural groove |
| DNA-binding domain | 0.6034 | INHERITED FROM: eye primordium |
| FnI-like domain | 0.7081 | INHERITED FROM: hypochord || endoderm || somite || prechordal plate |
| Kazal-type serine protease inhibitors | 0.7087 | INHERITED FROM: neural plate || hypochord || axial mesoderm || neural groove |
| Tropomyosin | 0.7397 | INHERITED FROM: dermomyotome || cardiac mesoderm || myotome |
| Globin-like | 0.7547 | INHERITED FROM: anterior dorsal lateral plate region || hematopoietic stem cell |
| Growth factor receptor domain | 0.7972 | INHERITED FROM: fin || tail tip || hypochord || coelom || anterior neural ridge || pre-chordal neural plate border |
| Phosphoglycerate mutase-like | 0.8223 | INHERITED FROM: animal pole || animal hemisphere |
| Integrin domains | 0.8491 | INHERITED FROM: mesodermal cell || fibroblast |
| Hemopexin-like domain | 0.8717 | INHERITED FROM: mesodermal cell || fibroblast |
| LDL receptor-like module | 0.95 | INHERITED FROM: hindgut |
| TSP-1 type 1 repeat | 1 | INHERITED FROM: hypochord |
| Metalloproteases ("zincins"), catalytic domain | 1 | INHERITED FROM: mesodermal cell || fibroblast |
| SH2 domain | 1 | INHERITED FROM: animal pole |
| EGF/Laminin | 1 | INHERITED FROM: hypochord || axial mesoderm || neural groove |
| Cadherin-like | 1 | INHERITED FROM: neural crest |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Nucleoplasmin-like core domain | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| LysM domain | 0 | Direct |
| C-terminal domain of adenylylcyclase associated protein | 0 | Direct |
| Translation proteins SH3-like domain | 0 | Direct |
| PAH2 domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Synuclein | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0 | Direct |
| E2F-DP heterodimerization region | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Eferin C-derminal domain-like | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Tim10-like | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| GINS helical bundle-like | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Mib/herc2 domain-like | 0 | Direct |
| PriA/YqbF domain | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| Zn-binding ribosomal proteins | 0 | Direct |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| Trefoil | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Sm-like ribonucleoproteins | 0 | Direct |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| Ribonuclease PH domain 2-like | 0 | Direct |
| Proteasome activator | 0 | Direct |
| PAP/OAS1 substrate-binding domain | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| WGR domain-like | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| TSP type-3 repeat | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| Connexin43 | 0 | Direct |
| SIS domain | 0 | Direct |
| Soluble quinoprotein glucose dehydrogenase | 0 | Direct |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| BSD domain-like | 0 | Direct |
| Uracil-DNA glycosylase-like | 0 | Direct |
| Hedgehog/DD-peptidase | 0 | Direct |
| ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| DLC | 0 | Direct |
| Nop domain | 0 | Direct |
| Notch domain | 0 | Direct |
| Ribosomal proteins L15p and L18e | 0 | Direct |
| LuxS/MPP-like metallohydrolase | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
| SRF-like | 0 | Direct |
| Cytokine | 0 | Direct |
| Ribosomal L27 protein-like | 0 | Direct |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| PEBP-like | 0 | Direct |
| RNA-binding domain, RBD | 0.00000000000009245 | Direct |
| Homeodomain-like | 0.000000000001064 | Direct |
| "Winged helix" DNA-binding domain | 0.000000007781 | Direct |
| Nucleic acid-binding proteins | 0.000004193 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0.000005429 | Direct |
| Bromodomain | 0.0000946 | Direct |
| SAP domain | 0.0008311 | Direct |
| SET domain | 0.001427 | Inherited |
| HMG-box | 0.004327 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.005816 | Inherited |
| Cyclin-like | 0.009607 | Inherited |
| CCCH zinc finger | 0.00968 | Inherited |
| Frizzled cysteine-rich domain | 0.01439 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.02407 | Inherited |
| GroEL-intermediate domain like | 0.03685 | Inherited |
| GroEL equatorial domain-like | 0.03685 | Inherited |
| Thioredoxin-like | 0.06617 | Inherited |
| Tubulin C-terminal domain-like | 0.07151 | Inherited |
| ARID-like | 0.09156 | Inherited |
| Snake toxin-like | 0.1129 | Inherited |
| Actin-like ATPase domain | 0.1187 | Inherited |
| GroEL apical domain-like | 0.128 | Inherited |
| Alpha-macroglobulin receptor domain | 0.13 | Inherited |
| Tubulin nucleotide-binding domain-like | 0.1348 | Inherited |
| Cystine-knot cytokines | 0.1355 | Inherited |
| lambda repressor-like DNA-binding domains | 0.1722 | Inherited |
| Orange domain-like | 0.1775 | Inherited |
| Sema domain | 0.2189 | Inherited |
| Protein kinase-like (PK-like) | 0.2305 | Inherited |
| Mannose 6-phosphate receptor domain | 0.2425 | Inherited |
| p53-like transcription factors | 0.2751 | Inherited |
| Intermediate filament protein, coiled coil region | 0.2751 | Inherited |
| Troponin coil-coiled subunits | 0.3251 | Inherited |
| TIMP-like | 0.3314 | Inherited |
| Clavaminate synthase-like | 0.3995 | Inherited |
| Terpenoid cyclases/Protein prenyltransferases | 0.414 | Inherited |
| F-box domain | 0.4164 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.4919 | Inherited |
| Subtilisin-like | 0.5053 | Inherited |
| beta-beta-alpha zinc fingers | 0.5657 | Inherited |
| Plexin repeat | 0.5861 | Inherited |
| Kringle-like | 0.5905 | Inherited |
| DNA-binding domain | 0.6034 | Inherited |
| FnI-like domain | 0.7081 | Inherited |
| Kazal-type serine protease inhibitors | 0.7087 | Inherited |
| Tropomyosin | 0.7397 | Inherited |
| Globin-like | 0.7547 | Inherited |
| Growth factor receptor domain | 0.7972 | Inherited |
| Phosphoglycerate mutase-like | 0.8223 | Inherited |
| Integrin domains | 0.8491 | Inherited |
| Hemopexin-like domain | 0.8717 | Inherited |
| LDL receptor-like module | 0.95 | Inherited |
| TSP-1 type 1 repeat | 1 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 1 | Inherited |
| SH2 domain | 1 | Inherited |
| EGF/Laminin | 1 | Inherited |
| Cadherin-like | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this XA term (SDXA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Hedgehog (development protein), N-terminal signaling domain | 0 | DIRECT |
| Ferritin | 0 | DIRECT |
| Trunk domain of Sec23/24 | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | DIRECT |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | DIRECT |
| IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
| MIF4G domain-like | 0 | DIRECT |
| Pumilio repeat | 0 | DIRECT |
| RNA-polymerase beta | 0 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0 | DIRECT |
| ets domain | 0 | DIRECT |
| Mib/herc2 domain | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Eferin C-derminal domain-like | 0 | DIRECT |
| Phosphatidylethanolamine binding protein | 0 | DIRECT |
| E2F dimerization segment | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| HD domain | 0 | DIRECT |
| Thrombospondin C-terminal domain | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| Cell cycle transcription factor e2f-dp | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| HAT/Suf repeat | 0 | DIRECT |
| RUNT domain | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| Prefoldin | 0 | DIRECT |
| Guanido kinase catalytic domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| TRASH domain | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Paired domain | 0 | DIRECT |
| Pointed domain | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| MPP-like | 0 | DIRECT |
| Alpha-adaptin ear subdomain-like | 0 | DIRECT |
| IF2B-like | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| SIAH, seven in absentia homolog | 0 | DIRECT |
| Trefoil | 0 | DIRECT |
| RNA-polymerase beta-prime | 0 | DIRECT |
| PDI-like | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | DIRECT |
| LON domain-like | 0 | DIRECT |
| ATP-dependent DNA ligase catalytic domain | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| DLC | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Nucleoplasmin-like core domain | 0 | DIRECT |
| Alanine racemase-like, N-terminal domain | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | DIRECT |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
| Class II glutamine amidotransferases | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| N-type ATP pyrophosphatases | 0 | DIRECT |
| C-terminal domain of adenylylcyclase associated protein | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| ZZ domain | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| WGR domain | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| CAT-like | 0 | DIRECT |
| Noggin | 0 | DIRECT |
| Eukaryotic ODC-like | 0 | DIRECT |
| TATA-box binding protein (TBP), C-terminal domain | 0 | DIRECT |
| Tim10/DDP | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| Cyclin A/CDK2-associated p19, Skp2 | 0 | DIRECT |
| Ribosomal proteins L15p and L18e | 0 | DIRECT |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| alpha-catenin/vinculin | 0 | DIRECT |
| Heat-shock transcription factor | 0 | DIRECT |
| A20-like zinc finger | 0 | DIRECT |
| ECR1 N-terminal domain-like | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| P4 origin-binding domain-like | 0 | DIRECT |
| Retinol binding protein-like | 0 | DIRECT |
| Ribonuclease PH domain 1-like | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| UBX domain | 0 | DIRECT |
| L domain | 0 | DIRECT |
| Pseudouridine synthase I TruA | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| BSD domain | 0 | DIRECT |
| Phosphoribosylpyrophosphate synthetase-like | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| Ribonuclease PH domain 2-like | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Ran-binding domain | 0 | DIRECT |
| S-adenosylhomocystein hydrolase | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| Fibroblast growth factors (FGF) | 0 | DIRECT |
| SH3BGR (SH3-binding, glutamic acid-rich protein-like) | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| Polo-box duplicated region | 0 | DIRECT |
| NLI interacting factor-like phosphatase | 0 | DIRECT |
| Serine carboxypeptidase-like | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
| GDI-like N domain | 0 | DIRECT |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | DIRECT |
| B56-like | 0 | DIRECT |
| Canonical RBD | 0.0000000000001556 | DIRECT |
| Homeodomain | 0.00000000008853 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0.000008821 | DIRECT |
| Forkhead DNA-binding domain | 0.00002588 | DIRECT |
| Bromodomain | 0.0001058 | DIRECT |
| Cold shock DNA-binding domain-like | 0.0001649 | DIRECT |
| Cyclin | 0.0005872 | DIRECT |
| SAP domain | 0.0008122 | DIRECT |
| Histone lysine methyltransferases | 0.001317 | INHERITED FROM: primary germ layer |
| PHD domain | 0.001668 | INHERITED FROM: primary germ layer |
| Tandem AAA-ATPase domain | 0.004212 | INHERITED FROM: blastopore || marginal zone || blastopore lip || vegetal yolk mass || upper blastopore lip |
| Transforming growth factor (TGF)-beta | 0.004645 | INHERITED FROM: embryonic structure || early distal tubule || bottle cell || mouth primordium || vegetal hemisphere || involuting marginal zone || involuting marginal zone mesenchymal layer || neurogenic placode || dorsal marginal zone || ventral mesoderm || gastrocoel roof plate || circumblastoporal collar || axial mesoderm || vegetal endoderm || early embryonic cell || endoderm || animal hemisphere || mesoderm || involuted dorsal mesoderm || head mesoderm || prechordal plate || heart primordium |
| HMG-box | 0.004837 | INHERITED FROM: embryonic structure || mandibular crest || neural plate border || neural plate || lower blastopore lip || pre-chordal neural plate || neurogenic placode || optic field || cranial neural crest || neuroectoderm || posterior branchial crest || retinal layer || endocardial tube || anterior neural fold || endoderm || neuroectoderm outer layer || neural fold || anterior branchial crest || midbrain-hindbrain boundary || hyoid crest |
| Transducin (alpha subunit), insertion domain | 0.005458 | INHERITED FROM: dorsal marginal zone || pronephric kidney || coelom || animal hemisphere |
| Eukaryotic type KH-domain (KH-domain type I) | 0.008457 | INHERITED FROM: upper blastopore lip |
| CCCH zinc finger | 0.009826 | INHERITED FROM: animal pole |
| Frizzled cysteine-rich domain | 0.01416 | INHERITED FROM: embryonic structure || optic vesicle || mouth primordium || tail tip || neural plate || pre-chordal neural plate || liver primordium || stomodeal-hypophyseal primordium || stomach || optic field || neural tube || neuroectoderm || primordium || cardiac mesoderm || axial mesoderm || coelom || anterior neural fold || endoderm || presumptive paraxial mesoderm || lateral plate mesoderm || tail fin || mesoderm || somite || neural fold || involuted dorsal mesoderm || gall bladder || prechordal plate || presomitic mesoderm || midbrain-hindbrain boundary || foregut |
| Actin/HSP70 | 0.02457 | INHERITED FROM: head somite || trunk somite || head mesoderm |
| T-box | 0.02836 | INHERITED FROM: embryonic structure || involuting marginal zone || lower blastopore lip || neurogenic placode || circumblastoporal collar || cardiac mesoderm || axial mesoderm || mesoderm || involuted dorsal mesoderm || heart primordium || foregut || involuted ventral mesoderm |
| POU-specific domain | 0.0416 | INHERITED FROM: early distal tubule || presumptive midbrain-hindbrain boundary || neural plate || pre-chordal neural plate || neurogenic placode || neural tube || neuroectoderm || pronephric duct || distal tubule || pronephric tubule || late distal tubule || neural fold || proximal tubule || chordal neural plate |
| Group II chaperonin (CCT, TRIC), apical domain | 0.05246 | INHERITED FROM: anterior dorsal lateral plate region |
| LIM domain | 0.05636 | INHERITED FROM: cranial placode |
| Glutathione peroxidase-like | 0.06033 | INHERITED FROM: early distal tubule || eye primordium || cranial neural crest || early proximal tubule || presumptive paraxial mesoderm || distal tubule || pronephric nephron || pronephric tubule || paraxial mesoderm || proximal tubule || presomitic mesoderm || foregut |
| Tubulin, GTPase domain | 0.0702 | INHERITED FROM: vegetal hemisphere || epidermal cell || epidermis || gastrocoel roof plate || non-neural ectoderm |
| Tubulin, C-terminal domain | 0.0702 | INHERITED FROM: vegetal hemisphere || epidermal cell || epidermis || gastrocoel roof plate || non-neural ectoderm |
| Complement components | 0.08015 | INHERITED FROM: hindgut || endoderm || midgut |
| ARID domain | 0.08654 | INHERITED FROM: pronephric tubule |
| Sema domain | 0.1039 | INHERITED FROM: embryonic structure || presumptive midbrain-hindbrain boundary || neural plate || cranial placode || otic placode || cranial neural crest || neuroectoderm || involuted dorsal mesoderm || neural crest || midbrain-hindbrain boundary |
| Alpha-macroglobulin receptor domain | 0.1214 | INHERITED FROM: hindgut || midgut || archenteron || foregut |
| Cell cycle control phosphatase, catalytic domain | 0.1214 | INHERITED FROM: neural plate || neuroectoderm || chordal neural plate |
| Hairy Orange domain | 0.1697 | INHERITED FROM: fin || chordoneural hinge || tail tip || cranial placode || pre-chordal neural plate || neural tube || neuroectoderm || coelom || anterior neural fold || lateral plate mesoderm || neural groove || intermediate mesoderm || paraxial mesoderm || mesoderm || neural fold || presomitic mesoderm |
| Growth factor receptor domain | 0.2002 | INHERITED FROM: fin || hypochord || coelom || animal hemisphere || mesoderm |
| Mannose 6-phosphate receptor domain | 0.2328 | INHERITED FROM: cement gland primordium |
| VWC domain | 0.2551 | INHERITED FROM: hypochord || neural tube || endoderm || mesoderm || prechordal plate |
| Intermediate filament protein, coiled coil region | 0.2854 | INHERITED FROM: epidermis |
| Erythroid transcription factor GATA-1 | 0.314 | INHERITED FROM: cardiac progenitor cell || liver diverticulum || primordium || anterior dorsal lateral plate region || cardiac mesoderm || hematopoietic stem cell || archenteron floor || endoderm || lateral plate mesoderm || archenteron || mesoderm |
| Class I aldolase | 0.314 | INHERITED FROM: primordium || pronephric kidney || coelom |
| Protein kinases, catalytic subunit | 0.3863 | INHERITED FROM: animal hemisphere || head mesoderm |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.4072 | INHERITED FROM: pronephric nephron || pronephric tubule || mesoderm || somite |
| Parvalbumin | 0.4134 | INHERITED FROM: somite |
| Multidrug efflux transporter AcrB transmembrane domain | 0.4134 | INHERITED FROM: epidermis |
| AAT-like | 0.4134 | INHERITED FROM: pronephric duct |
| Ephrin ectodomain | 0.4134 | INHERITED FROM: sensorial layer of neurectoderm |
| Arginine methyltransferase | 0.4134 | INHERITED FROM: optic vesicle || cranial neural crest |
| F-box domain | 0.4324 | INHERITED FROM: animal hemisphere |
| I set domains | 0.4901 | INHERITED FROM: optic vesicle |
| Ovomucoid domain III-like | 0.4957 | INHERITED FROM: neural plate || hypochord || neural groove |
| Ephrin receptor ligand binding domain | 0.516 | INHERITED FROM: branchial crest |
| Kringle modules | 0.5605 | INHERITED FROM: neural groove |
| Classic zinc finger, C2H2 | 0.5727 | INHERITED FROM: neural plate border || chordal neural plate border || pre-chordal neural plate || presumptive rhombomere || anterior neural fold || anterior neural ridge || splanchnic layer of lateral plate mesoderm || neural fold || chordal neural plate || pre-chordal neural plate border |
| Subtilases | 0.5917 | INHERITED FROM: vegetal hemisphere |
| Plexin repeat | 0.5928 | INHERITED FROM: presumptive midbrain-hindbrain boundary || cranial placode || liver primordium || otic placode || cranial neural crest || neuroectoderm || neural crest |
| Tropomyosin | 0.6041 | INHERITED FROM: dermomyotome || cardiac mesoderm || myotome |
| Proprotein convertase P-domain | 0.6292 | INHERITED FROM: vegetal hemisphere || animal hemisphere |
| Matrix metalloproteases, catalytic domain | 0.6628 | INHERITED FROM: mesodermal cell || fibroblast |
| Globins | 0.743 | INHERITED FROM: anterior dorsal lateral plate region || hematopoietic stem cell |
| Integrin domains | 0.8446 | INHERITED FROM: mesodermal cell || fibroblast |
| Hemopexin-like domain | 0.8676 | INHERITED FROM: mesodermal cell || fibroblast |
| LDL receptor-like module | 0.9488 | INHERITED FROM: hindgut |
| Calmodulin-like | 0.9858 | INHERITED FROM: ciliated epidermal cell |
| SH2 domain | 1 | INHERITED FROM: animal pole |
| TSP-1 type 1 repeat | 1 | INHERITED FROM: hypochord |
| Phosphotyrosine-binding domain (PTB) | 1 | INHERITED FROM: early embryonic cell |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Hedgehog (development protein), N-terminal signaling domain | 0 | Direct |
| Ferritin | 0 | Direct |
| Trunk domain of Sec23/24 | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | Direct |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | Direct |
| IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
| MIF4G domain-like | 0 | Direct |
| Pumilio repeat | 0 | Direct |
| RNA-polymerase beta | 0 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0 | Direct |
| ets domain | 0 | Direct |
| Mib/herc2 domain | 0 | Direct |
| NTF2-like | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Eferin C-derminal domain-like | 0 | Direct |
| Phosphatidylethanolamine binding protein | 0 | Direct |
| E2F dimerization segment | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| HD domain | 0 | Direct |
| Thrombospondin C-terminal domain | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| Cell cycle transcription factor e2f-dp | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| HAT/Suf repeat | 0 | Direct |
| RUNT domain | 0 | Direct |
| Proteasome activator | 0 | Direct |
| Prefoldin | 0 | Direct |
| Guanido kinase catalytic domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| TRASH domain | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Paired domain | 0 | Direct |
| Pointed domain | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| MPP-like | 0 | Direct |
| Alpha-adaptin ear subdomain-like | 0 | Direct |
| IF2B-like | 0 | Direct |
| SRF-like | 0 | Direct |
| Notch domain | 0 | Direct |
| SIAH, seven in absentia homolog | 0 | Direct |
| Trefoil | 0 | Direct |
| RNA-polymerase beta-prime | 0 | Direct |
| PDI-like | 0 | Direct |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | Direct |
| LON domain-like | 0 | Direct |
| ATP-dependent DNA ligase catalytic domain | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| DLC | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Nucleoplasmin-like core domain | 0 | Direct |
| Alanine racemase-like, N-terminal domain | 0 | Direct |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | Direct |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
| Class II glutamine amidotransferases | 0 | Direct |
| SMAD domain | 0 | Direct |
| N-type ATP pyrophosphatases | 0 | Direct |
| C-terminal domain of adenylylcyclase associated protein | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| ZZ domain | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| WGR domain | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| CAT-like | 0 | Direct |
| Noggin | 0 | Direct |
| Eukaryotic ODC-like | 0 | Direct |
| TATA-box binding protein (TBP), C-terminal domain | 0 | Direct |
| Tim10/DDP | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| Cyclin A/CDK2-associated p19, Skp2 | 0 | Direct |
| Ribosomal proteins L15p and L18e | 0 | Direct |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | Direct |
| PAH2 domain | 0 | Direct |
| alpha-catenin/vinculin | 0 | Direct |
| Heat-shock transcription factor | 0 | Direct |
| A20-like zinc finger | 0 | Direct |
| ECR1 N-terminal domain-like | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| P4 origin-binding domain-like | 0 | Direct |
| Retinol binding protein-like | 0 | Direct |
| Ribonuclease PH domain 1-like | 0 | Direct |
| Connexin43 | 0 | Direct |
| UBX domain | 0 | Direct |
| L domain | 0 | Direct |
| Pseudouridine synthase I TruA | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| BSD domain | 0 | Direct |
| Phosphoribosylpyrophosphate synthetase-like | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| Ribonuclease PH domain 2-like | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Ran-binding domain | 0 | Direct |
| S-adenosylhomocystein hydrolase | 0 | Direct |
| Nop domain | 0 | Direct |
| LysM domain | 0 | Direct |
| Fibroblast growth factors (FGF) | 0 | Direct |
| SH3BGR (SH3-binding, glutamic acid-rich protein-like) | 0 | Direct |
| Synuclein | 0 | Direct |
| TSP type-3 repeat | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| Cullin repeat | 0 | Direct |
| Polo-box duplicated region | 0 | Direct |
| NLI interacting factor-like phosphatase | 0 | Direct |
| Serine carboxypeptidase-like | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
| GDI-like N domain | 0 | Direct |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | Direct |
| B56-like | 0 | Direct |
| Canonical RBD | 0.0000000000001556 | Direct |
| Homeodomain | 0.00000000008853 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0.000008821 | Direct |
| Forkhead DNA-binding domain | 0.00002588 | Direct |
| Bromodomain | 0.0001058 | Direct |
| Cold shock DNA-binding domain-like | 0.0001649 | Direct |
| Cyclin | 0.0005872 | Direct |
| SAP domain | 0.0008122 | Direct |
| Histone lysine methyltransferases | 0.001317 | Inherited |
| PHD domain | 0.001668 | Inherited |
| Tandem AAA-ATPase domain | 0.004212 | Inherited |
| Transforming growth factor (TGF)-beta | 0.004645 | Inherited |
| HMG-box | 0.004837 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.005458 | Inherited |
| Eukaryotic type KH-domain (KH-domain type I) | 0.008457 | Inherited |
| CCCH zinc finger | 0.009826 | Inherited |
| Frizzled cysteine-rich domain | 0.01416 | Inherited |
| Actin/HSP70 | 0.02457 | Inherited |
| T-box | 0.02836 | Inherited |
| POU-specific domain | 0.0416 | Inherited |
| Group II chaperonin (CCT, TRIC), apical domain | 0.05246 | Inherited |
| LIM domain | 0.05636 | Inherited |
| Glutathione peroxidase-like | 0.06033 | Inherited |
| Tubulin, GTPase domain | 0.0702 | Inherited |
| Tubulin, C-terminal domain | 0.0702 | Inherited |
| Complement components | 0.08015 | Inherited |
| ARID domain | 0.08654 | Inherited |
| Sema domain | 0.1039 | Inherited |
| Alpha-macroglobulin receptor domain | 0.1214 | Inherited |
| Cell cycle control phosphatase, catalytic domain | 0.1214 | Inherited |
| Hairy Orange domain | 0.1697 | Inherited |
| Growth factor receptor domain | 0.2002 | Inherited |
| Mannose 6-phosphate receptor domain | 0.2328 | Inherited |
| VWC domain | 0.2551 | Inherited |
| Intermediate filament protein, coiled coil region | 0.2854 | Inherited |
| Erythroid transcription factor GATA-1 | 0.314 | Inherited |
| Class I aldolase | 0.314 | Inherited |
| Protein kinases, catalytic subunit | 0.3863 | Inherited |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.4072 | Inherited |
| Parvalbumin | 0.4134 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.4134 | Inherited |
| AAT-like | 0.4134 | Inherited |
| Ephrin ectodomain | 0.4134 | Inherited |
| Arginine methyltransferase | 0.4134 | Inherited |
| F-box domain | 0.4324 | Inherited |
| I set domains | 0.4901 | Inherited |
| Ovomucoid domain III-like | 0.4957 | Inherited |
| Ephrin receptor ligand binding domain | 0.516 | Inherited |
| Kringle modules | 0.5605 | Inherited |
| Classic zinc finger, C2H2 | 0.5727 | Inherited |
| Subtilases | 0.5917 | Inherited |
| Plexin repeat | 0.5928 | Inherited |
| Tropomyosin | 0.6041 | Inherited |
| Proprotein convertase P-domain | 0.6292 | Inherited |
| Matrix metalloproteases, catalytic domain | 0.6628 | Inherited |
| Globins | 0.743 | Inherited |
| Integrin domains | 0.8446 | Inherited |
| Hemopexin-like domain | 0.8676 | Inherited |
| LDL receptor-like module | 0.9488 | Inherited |
| Calmodulin-like | 0.9858 | Inherited |
| SH2 domain | 1 | Inherited |
| TSP-1 type 1 repeat | 1 | Inherited |
| Phosphotyrosine-binding domain (PTB) | 1 | Inherited |
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this XA term (SPXA level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Zn-binding ribosomal proteins | 0 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| Hedgehog/DD-peptidase | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| LuxS/MPP-like metallohydrolase | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| Eferin C-derminal domain-like | 0 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| PEBP-like | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Nucleoplasmin-like core domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Cryptochrome/photolyase, N-terminal domain | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
| GINS helical bundle-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| E2F-DP heterodimerization region | 0 | DIRECT |
| DLC | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| FtsH protease domain-like | 0 | DIRECT |
| Trefoil | 0 | DIRECT |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | DIRECT |
| Uracil-DNA glycosylase-like | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| Soluble quinoprotein glucose dehydrogenase | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| Ribosomal L27 protein-like | 0 | DIRECT |
| BSD domain-like | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| Ribosomal proteins L15p and L18e | 0 | DIRECT |
| Ribonuclease PH domain 2-like | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Tim10-like | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| Sm-like ribonucleoproteins | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Mib/herc2 domain-like | 0 | DIRECT |
| C-terminal domain of adenylylcyclase associated protein | 0 | DIRECT |
| Ribulose-phoshate binding barrel | 0 | DIRECT |
| Translation proteins SH3-like domain | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| PriA/YqbF domain | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Cytokine | 0 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0 | DIRECT |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
| PAP/OAS1 substrate-binding domain | 0 | DIRECT |
| RNA-binding domain, RBD | 0.00000000000006406 | DIRECT |
| Homeodomain-like | 0.000000000000738 | DIRECT |
| "Winged helix" DNA-binding domain | 0.000000005448 | DIRECT |
| Nucleic acid-binding proteins | 0.000003006 | DIRECT |
| HLH, helix-loop-helix DNA-binding domain | 0.000003894 | DIRECT |
| Bromodomain | 0.00006978 | DIRECT |
| SAP domain | 0.0006292 | DIRECT |
| SET domain | 0.001088 | INHERITED FROM: primary germ layer |
| HMG-box | 0.003345 | INHERITED FROM: hyoid crest || neural plate || neural crest || anterior branchial crest || mandibular crest || neurogenic placode || neural fold || posterior branchial crest || neuroectoderm || lower blastopore lip || neural plate border || neuroectoderm outer layer || retinal layer || midbrain-hindbrain boundary || optic field || anterior neural fold || chordal neural plate || cranial neural crest || branchial crest || embryonic structure || endoderm || posterior placodal area || pre-chordal neural plate || endocardial tube |
| Transducin (alpha subunit), insertion domain | 0.004518 | INHERITED FROM: pronephric kidney || animal hemisphere || coelom || dorsal marginal zone |
| Cyclin-like | 0.007526 | INHERITED FROM: postmigratory neural crest cell || animal pole |
| CCCH zinc finger | 0.007584 | INHERITED FROM: animal pole |
| Frizzled cysteine-rich domain | 0.01134 | INHERITED FROM: somite || stomodeal-hypophyseal primordium || neural plate || foregut || presomitic mesoderm || prechordal plate || axial mesoderm || mesoderm || neural fold || primordium || stomach || tail tip || neuroectoderm || midbrain-hindbrain boundary || presumptive paraxial mesoderm || lateral plate mesoderm || liver primordium || optic field || anterior neural fold || optic vesicle || tail fin || cardiac mesoderm || embryonic structure || involuted dorsal mesoderm || gall bladder || mouth primordium || coelom || neural tube || endoderm || pre-chordal neural plate |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.0192 | INHERITED FROM: sensorial layer of neurectoderm || preplacodal ectoderm || cranial placode || neuroectoderm || proximal tubule branch || archenteron floor || embryonic structure || post-anal gut || anterior placodal area || liver diverticulum |
| GroEL-intermediate domain like | 0.0299 | INHERITED FROM: endomesoderm || anterior dorsal lateral plate region |
| GroEL equatorial domain-like | 0.0299 | INHERITED FROM: endomesoderm || anterior dorsal lateral plate region |
| Thioredoxin-like | 0.05486 | INHERITED FROM: early proximal tubule |
| Tubulin C-terminal domain-like | 0.05948 | INHERITED FROM: epidermis || non-neural ectoderm || gastrocoel roof plate || vegetal hemisphere || epidermal cell |
| ARID-like | 0.07701 | INHERITED FROM: pronephric tubule |
| Snake toxin-like | 0.0962 | INHERITED FROM: neural plate || mesoderm || dorsal lateral plate mesoderm || neuroectoderm || head mesoderm || animal hemisphere || ventral mesoderm || lateral plate mesoderm || chordal neural plate || involuted dorsal mesoderm || pre-chordal neural plate |
| Actin-like ATPase domain | 0.1017 | INHERITED FROM: head somite |
| GroEL apical domain-like | 0.1102 | INHERITED FROM: anterior dorsal lateral plate region |
| Alpha-macroglobulin receptor domain | 0.1121 | INHERITED FROM: midgut || foregut || archenteron || hindgut |
| Tubulin nucleotide-binding domain-like | 0.1166 | INHERITED FROM: epidermis || non-neural ectoderm || gastrocoel roof plate || vegetal hemisphere || epidermal cell |
| Cystine-knot cytokines | 0.1172 | INHERITED FROM: prechordal plate || axial mesoderm || mesoderm || involuting marginal zone mesenchymal layer || neurogenic placode || bottle cell || vegetal endoderm || neuroectoderm || head mesoderm || animal hemisphere || involuting marginal zone || ventral mesoderm || circumblastoporal collar || embryonic structure || involuted dorsal mesoderm || early embryonic cell || neural groove || mouth primordium || vegetal hemisphere || neural tube || endoderm || dorsal marginal zone |
| lambda repressor-like DNA-binding domains | 0.1508 | INHERITED FROM: neural plate || pronephric tubule || neurogenic placode || neural fold || cranial placode || proximal tubule || early distal tubule || neuroectoderm || presumptive midbrain-hindbrain boundary || distal tubule || chordal neural plate || late distal tubule || neural tube |
| Orange domain-like | 0.1557 | INHERITED FROM: presomitic mesoderm || mesoderm || neural fold || cranial placode || tail tip || neuroectoderm || neural plate border || chordoneural hinge || intermediate mesoderm || paraxial mesoderm || fin || lateral plate mesoderm || anterior neural fold || neural groove || coelom || neural tube || pre-chordal neural plate |
| Sema domain | 0.1943 | INHERITED FROM: neural crest || cranial placode || neuroectoderm || presumptive midbrain-hindbrain boundary || cranial neural crest || embryonic structure || involuted dorsal mesoderm || otic placode |
| Protein kinase-like (PK-like) | 0.2055 | INHERITED FROM: head mesoderm || animal hemisphere |
| Mannose 6-phosphate receptor domain | 0.2167 | INHERITED FROM: cement gland primordium |
| Intermediate filament protein, coiled coil region | 0.2473 | INHERITED FROM: epidermis |
| p53-like transcription factors | 0.2473 | INHERITED FROM: neural plate || foregut || mesoderm || neurogenic placode || cranial placode || primordium || neuroectoderm || lower blastopore lip || lung primordium || lung bud || involuted ventral mesoderm |
| Troponin coil-coiled subunits | 0.2955 | INHERITED FROM: mesoderm |
| TIMP-like | 0.3015 | INHERITED FROM: stomodeal-hypophyseal primordium || foregut || prechordal plate || optic field || endoderm || pre-chordal neural plate |
| Clavaminate synthase-like | 0.3682 | INHERITED FROM: late proximal tubule || late distal tubule || early proximal tubule |
| Terpenoid cyclases/Protein prenyltransferases | 0.3819 | INHERITED FROM: midgut || hindgut |
| F-box domain | 0.384 | INHERITED FROM: animal hemisphere || optic vesicle |
| PYP-like sensor domain (PAS domain) | 0.4577 | INHERITED FROM: somite || mesoderm |
| Subtilisin-like | 0.4706 | INHERITED FROM: vegetal hemisphere |
| beta-beta-alpha zinc fingers | 0.5292 | INHERITED FROM: chordal neural plate border || neural fold || presumptive rhombomere || pre-chordal neural plate border || anterior neural ridge || chordal neural plate || splanchnic layer of lateral plate mesoderm || pre-chordal neural plate |
| Plexin repeat | 0.5501 | INHERITED FROM: neural crest || cranial placode || neuroectoderm || liver primordium || presumptive midbrain-hindbrain boundary || cranial neural crest || involuted dorsal mesoderm || otic placode |
| Kringle-like | 0.5547 | INHERITED FROM: neural groove |
| DNA-binding domain | 0.5677 | INHERITED FROM: eye primordium |
| FnI-like domain | 0.6731 | INHERITED FROM: somite || hypochord || prechordal plate || neural tube || endoderm |
| Kazal-type serine protease inhibitors | 0.6737 | INHERITED FROM: neural plate || hypochord || axial mesoderm || neural groove |
| Tropomyosin | 0.7048 | INHERITED FROM: dermomyotome || myotome || cardiac mesoderm |
| Globin-like | 0.7198 | INHERITED FROM: lateral plate mesoderm || hematopoietic stem cell || anterior dorsal lateral plate region |
| Growth factor receptor domain | 0.7653 | INHERITED FROM: hypochord || tail tip || pre-chordal neural plate border || anterior neural ridge || fin || coelom |
| Phosphoglycerate mutase-like | 0.7914 | INHERITED FROM: animal hemisphere || animal pole |
| Integrin domains | 0.8188 | INHERITED FROM: fibroblast || mesodermal cell |
| Hemopexin-like domain | 0.8423 | INHERITED FROM: fibroblast || mesodermal cell |
| LDL receptor-like module | 0.9216 | INHERITED FROM: hindgut |
| EGF/Laminin | 1 | INHERITED FROM: hypochord || axial mesoderm || dorsal fin || neural groove |
| TSP-1 type 1 repeat | 1 | INHERITED FROM: hypochord |
| Metalloproteases ("zincins"), catalytic domain | 1 | INHERITED FROM: fibroblast || mesodermal cell |
| Cadherin-like | 1 | INHERITED FROM: neural crest || neuroectoderm |
| SH2 domain | 1 | INHERITED FROM: animal pole |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Zn-binding ribosomal proteins | 0 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| Hedgehog/DD-peptidase | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| LuxS/MPP-like metallohydrolase | 0 | Direct |
| TSP type-3 repeat | 0 | Direct |
| Nop domain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| Eferin C-derminal domain-like | 0 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
| Synuclein | 0 | Direct |
| PEBP-like | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Nucleoplasmin-like core domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| SIS domain | 0 | Direct |
| Cryptochrome/photolyase, N-terminal domain | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Connexin43 | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
| GINS helical bundle-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| LysM domain | 0 | Direct |
| ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| E2F-DP heterodimerization region | 0 | Direct |
| DLC | 0 | Direct |
| WGR domain-like | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| FtsH protease domain-like | 0 | Direct |
| Trefoil | 0 | Direct |
| Subunits of heterodimeric actin filament capping protein Capz | 0 | Direct |
| Uracil-DNA glycosylase-like | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| Soluble quinoprotein glucose dehydrogenase | 0 | Direct |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
| Ribosomal L27 protein-like | 0 | Direct |
| BSD domain-like | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| SRF-like | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| Ribosomal proteins L15p and L18e | 0 | Direct |
| Ribonuclease PH domain 2-like | 0 | Direct |
| Proteasome activator | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| PAH2 domain | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Tim10-like | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| Sm-like ribonucleoproteins | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Mib/herc2 domain-like | 0 | Direct |
| C-terminal domain of adenylylcyclase associated protein | 0 | Direct |
| Ribulose-phoshate binding barrel | 0 | Direct |
| Translation proteins SH3-like domain | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| PriA/YqbF domain | 0 | Direct |
| Notch domain | 0 | Direct |
| Cytokine | 0 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0 | Direct |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
| PAP/OAS1 substrate-binding domain | 0 | Direct |
| RNA-binding domain, RBD | 0.00000000000006406 | Direct |
| Homeodomain-like | 0.000000000000738 | Direct |
| "Winged helix" DNA-binding domain | 0.000000005448 | Direct |
| Nucleic acid-binding proteins | 0.000003006 | Direct |
| HLH, helix-loop-helix DNA-binding domain | 0.000003894 | Direct |
| Bromodomain | 0.00006978 | Direct |
| SAP domain | 0.0006292 | Direct |
| SET domain | 0.001088 | Inherited |
| HMG-box | 0.003345 | Inherited |
| Transducin (alpha subunit), insertion domain | 0.004518 | Inherited |
| Cyclin-like | 0.007526 | Inherited |
| CCCH zinc finger | 0.007584 | Inherited |
| Frizzled cysteine-rich domain | 0.01134 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.0192 | Inherited |
| GroEL-intermediate domain like | 0.0299 | Inherited |
| GroEL equatorial domain-like | 0.0299 | Inherited |
| Thioredoxin-like | 0.05486 | Inherited |
| Tubulin C-terminal domain-like | 0.05948 | Inherited |
| ARID-like | 0.07701 | Inherited |
| Snake toxin-like | 0.0962 | Inherited |
| Actin-like ATPase domain | 0.1017 | Inherited |
| GroEL apical domain-like | 0.1102 | Inherited |
| Alpha-macroglobulin receptor domain | 0.1121 | Inherited |
| Tubulin nucleotide-binding domain-like | 0.1166 | Inherited |
| Cystine-knot cytokines | 0.1172 | Inherited |
| lambda repressor-like DNA-binding domains | 0.1508 | Inherited |
| Orange domain-like | 0.1557 | Inherited |
| Sema domain | 0.1943 | Inherited |
| Protein kinase-like (PK-like) | 0.2055 | Inherited |
| Mannose 6-phosphate receptor domain | 0.2167 | Inherited |
| Intermediate filament protein, coiled coil region | 0.2473 | Inherited |
| p53-like transcription factors | 0.2473 | Inherited |
| Troponin coil-coiled subunits | 0.2955 | Inherited |
| TIMP-like | 0.3015 | Inherited |
| Clavaminate synthase-like | 0.3682 | Inherited |
| Terpenoid cyclases/Protein prenyltransferases | 0.3819 | Inherited |
| F-box domain | 0.384 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.4577 | Inherited |
| Subtilisin-like | 0.4706 | Inherited |
| beta-beta-alpha zinc fingers | 0.5292 | Inherited |
| Plexin repeat | 0.5501 | Inherited |
| Kringle-like | 0.5547 | Inherited |
| DNA-binding domain | 0.5677 | Inherited |
| FnI-like domain | 0.6731 | Inherited |
| Kazal-type serine protease inhibitors | 0.6737 | Inherited |
| Tropomyosin | 0.7048 | Inherited |
| Globin-like | 0.7198 | Inherited |
| Growth factor receptor domain | 0.7653 | Inherited |
| Phosphoglycerate mutase-like | 0.7914 | Inherited |
| Integrin domains | 0.8188 | Inherited |
| Hemopexin-like domain | 0.8423 | Inherited |
| LDL receptor-like module | 0.9216 | Inherited |
| EGF/Laminin | 1 | Inherited |
| TSP-1 type 1 repeat | 1 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 1 | Inherited |
| Cadherin-like | 1 | Inherited |
| SH2 domain | 1 | Inherited |
(show details)
Supra-domains annotated to this XA term (SPXA level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
103647,49899
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
88723,47807
88723 - PIN domain-like
47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | DIRECT |
110324,50249
110324 - Ribosomal L27 protein-like
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | DIRECT |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | DIRECT |
46966,47473
46966 - Spectrin repeat
47473 - EF-hand | 0 | DIRECT |
55945,55945
55945 - TATA-box binding protein-like
55945 - TATA-box binding protein-like | 0 | DIRECT |
51230,47005
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
142921,47587
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
52425,48173
52425 - Cryptochrome/photolyase, N-terminal domain
48173 - Cryptochrome/photolyase FAD-binding domain | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0 | DIRECT |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | DIRECT |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | DIRECT |
52058,49265
52058 - L domain-like
49265 - Fibronectin type III | 0 | DIRECT |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | DIRECT |
57184,49265
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | DIRECT |
47005,52777
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
81995,81811
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | DIRECT |
81296,48239
81296 - E set domains
48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
53300,81995
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0 | DIRECT |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
47095,47095
47095 - HMG-box
47095 - HMG-box | 0 | DIRECT |
48034,55931
48034 - Guanido kinase N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0 | DIRECT |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0 | DIRECT |
117839,117839
117839 - WWE domain
117839 - WWE domain | 0 | DIRECT |
49899,48726
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin | 0 | DIRECT |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0 | DIRECT |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
50044,50156
50044 - SH3-domain
50156 - PDZ domain-like | 0 | DIRECT |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | DIRECT |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
48371,46785
48371 - ARM repeat
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
52540,140990
52540 - P-loop containing nucleoside triphosphate hydrolases
140990 - FtsH protease domain-like | 0 | DIRECT |
54631,54631
54631 - CBS-domain pair
54631 - CBS-domain pair | 0 | DIRECT |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | DIRECT |
55486,48371
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | DIRECT |
46565,57938
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | DIRECT |
57184,100895
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.0000002698 | DIRECT |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.001398 | INHERITED FROM: vegetal yolk mass || blastopore lip || blastopore || upper blastopore lip |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.002282 | INHERITED FROM: postmigratory neural crest cell || posterior neural tube || migratory neural crest cell || animal hemisphere || eye primordium || animal pole || embryonic structure |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.004518 | INHERITED FROM: pronephric kidney || animal hemisphere || coelom || dorsal marginal zone |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.005359 | INHERITED FROM: sensorial layer of neurectoderm || preplacodal ectoderm || archenteron || cranial placode || neuroectoderm || archenteron floor || cardiac mesoderm || embryonic structure || post-anal gut || anterior dorsal lateral plate region || anterior placodal area || endoderm |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0.0299 | INHERITED FROM: animal hemisphere || animal pole |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.05948 | INHERITED FROM: epidermis || non-neural ectoderm || gastrocoel roof plate || vegetal hemisphere || epidermal cell |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0.07311 | INHERITED FROM: neural crest || cranial placode || neuroectoderm || midbrain-hindbrain boundary || cranial neural crest || branchial crest |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0.0962 | INHERITED FROM: neuroectoderm || animal hemisphere || cranial neural crest |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.1025 | INHERITED FROM: head somite |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.1102 | INHERITED FROM: somite |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.1557 | INHERITED FROM: presomitic mesoderm || mesoderm || neural fold || cranial placode || tail tip || neuroectoderm || neural plate border || chordoneural hinge || intermediate mesoderm || paraxial mesoderm || fin || lateral plate mesoderm || anterior neural fold || neural groove || coelom || neural tube || pre-chordal neural plate |
90209,90209
90209 - Ran binding protein zinc finger-like
90209 - Ran binding protein zinc finger-like | 0.1702 | INHERITED FROM: vegetal yolk mass || blastopore lip || marginal zone || blastopore || upper blastopore lip |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.1702 | INHERITED FROM: mesoderm || neuroectoderm || endoderm |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0.1876 | INHERITED FROM: neural plate || pronephric tubule || neurogenic placode || neural fold || cranial placode || neuroectoderm || presumptive midbrain-hindbrain boundary || chordal neural plate || neural tube |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.1943 | INHERITED FROM: neural crest || cranial placode || neuroectoderm || presumptive midbrain-hindbrain boundary || cranial neural crest || embryonic structure || involuted dorsal mesoderm || otic placode |
57603,57603
57603 - FnI-like domain
57603 - FnI-like domain | 0.2167 | INHERITED FROM: chordal neural plate |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.2414 | INHERITED FROM: somite |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.2426 | INHERITED FROM: non-involuting marginal zone || animal hemisphere || animal pole |
64593,64593
64593 - Intermediate filament protein, coiled coil region
64593 - Intermediate filament protein, coiled coil region | 0.2539 | INHERITED FROM: epidermis |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.2955 | INHERITED FROM: neurogenic placode |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.2955 | INHERITED FROM: optic vesicle |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.3015 | INHERITED FROM: circumblastoporal collar |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.3822 | INHERITED FROM: chordal neural plate border || neural plate || neural fold || neuroectoderm || presumptive rhombomere || pre-chordal neural plate border || neural plate border || anterior neural ridge || lateral plate mesoderm || anterior neural fold || chordal neural plate || splanchnic layer of lateral plate mesoderm || pre-chordal neural plate |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0.61 | INHERITED FROM: cranial neural crest || branchial crest |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0.61 | INHERITED FROM: animal hemisphere || vegetal hemisphere |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.8664 | INHERITED FROM: presomitic mesoderm || dorsal marginal zone |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 0.8806 | INHERITED FROM: blastomere |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 1 | INHERITED FROM: neural groove || dorsal marginal zone |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 1 | INHERITED FROM: neural crest |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 1 | INHERITED FROM: non-involuting marginal zone || animal hemisphere || animal pole |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
103647,49899
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
88723,47807
88723 - PIN domain-like
47807 - 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | Direct |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | Direct |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | Direct |
110324,50249
110324 - Ribosomal L27 protein-like
50249 - Nucleic acid-binding proteins | 0 | Direct |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | Direct |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0 | Direct |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | Direct |
46966,47473
46966 - Spectrin repeat
47473 - EF-hand | 0 | Direct |
55945,55945
55945 - TATA-box binding protein-like
55945 - TATA-box binding protein-like | 0 | Direct |
51230,47005
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
142921,47587
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase | 0 | Direct |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | Direct |
52425,48173
52425 - Cryptochrome/photolyase, N-terminal domain
48173 - Cryptochrome/photolyase FAD-binding domain | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0 | Direct |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0 | Direct |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 0 | Direct |
52058,49265
52058 - L domain-like
49265 - Fibronectin type III | 0 | Direct |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | Direct |
57184,49265
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | Direct |
47005,52777
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | Direct |
81995,81811
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | Direct |
81296,48239
81296 - E set domains
48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
53300,81995
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0 | Direct |
52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
47095,47095
47095 - HMG-box
47095 - HMG-box | 0 | Direct |
48034,55931
48034 - Guanido kinase N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0 | Direct |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0 | Direct |
117839,117839
117839 - WWE domain
117839 - WWE domain | 0 | Direct |
49899,48726
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin | 0 | Direct |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0 | Direct |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
50044,50156
50044 - SH3-domain
50156 - PDZ domain-like | 0 | Direct |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | Direct |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
48371,46785
48371 - ARM repeat
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
52540,140990
52540 - P-loop containing nucleoside triphosphate hydrolases
140990 - FtsH protease domain-like | 0 | Direct |
54631,54631
54631 - CBS-domain pair
54631 - CBS-domain pair | 0 | Direct |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | Direct |
55486,48371
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | Direct |
46565,57938
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | Direct |
57184,100895
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | Direct |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.0000002698 | Direct |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.001398 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.002282 | Inherited |
47895,52540
47895 - Transducin (alpha subunit), insertion domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.004518 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.005359 | Inherited |
90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0.0299 | Inherited |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.05948 | Inherited |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0.07311 | Inherited |
81383,52047
81383 - F-box domain
52047 - RNI-like | 0.0962 | Inherited |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.1025 | Inherited |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.1102 | Inherited |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.1557 | Inherited |
90209,90209
90209 - Ran binding protein zinc finger-like
90209 - Ran binding protein zinc finger-like | 0.1702 | Inherited |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.1702 | Inherited |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0.1876 | Inherited |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.1943 | Inherited |
57603,57603
57603 - FnI-like domain
57603 - FnI-like domain | 0.2167 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.2414 | Inherited |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.2426 | Inherited |
64593,64593
64593 - Intermediate filament protein, coiled coil region
64593 - Intermediate filament protein, coiled coil region | 0.2539 | Inherited |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.2955 | Inherited |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.2955 | Inherited |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.3015 | Inherited |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.3822 | Inherited |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0.61 | Inherited |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0.61 | Inherited |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.8664 | Inherited |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 0.8806 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 1 | Inherited |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 1 | Inherited |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 1 | Inherited |
(show details)
Supra-domains annotated to this XA term (SPXA level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
52058,49265,49265
52058 - L domain-like
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
63737,55486,48371
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | DIRECT |
57196,57196,49899
57196 - EGF/Laminin
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
53300,81995,81811
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | DIRECT |
54768,54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
46565,57938,49493
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
103647,103647,49899
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
81995,81811,82754
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
142921,47587,56399
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | DIRECT |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
47220,47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
47769,47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | DIRECT |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | DIRECT |
90229,90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | DIRECT |
57184,52058,49265
57184 - Growth factor receptor domain
52058 - L domain-like
49265 - Fibronectin type III | 0 | DIRECT |
49899,48726,49265
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | DIRECT |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
51230,47005,52777
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
103647,103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | DIRECT |
46966,46966,47473
46966 - Spectrin repeat
46966 - Spectrin repeat
47473 - EF-hand | 0 | DIRECT |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.0299 | INHERITED FROM: somite |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0.04695 | INHERITED FROM: tail tip || chordoneural hinge || trunk somite || tail somite || coelom |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0.07311 | INHERITED FROM: neural crest || cranial placode || neuroectoderm || midbrain-hindbrain boundary || cranial neural crest || branchial crest |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.1102 | INHERITED FROM: sensorial layer of neurectoderm || presomitic mesoderm || tail tip || anterior neural fold || anterior placodal area || dorsal marginal zone |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0.1121 | INHERITED FROM: circumblastoporal collar || neural tube |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.1702 | INHERITED FROM: presomitic mesoderm || paraxial mesoderm || dorsal marginal zone |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.3054 | INHERITED FROM: neural plate || mesoderm || non-involuting marginal zone || neural fold || neuroectoderm || animal hemisphere || anterior neural fold || animal pole || coelom || pre-chordal neural plate |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.3214 | INHERITED FROM: non-neurogenic ectodermal placode |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.61 | INHERITED FROM: optic vesicle |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.8763 | INHERITED FROM: splanchnic layer of lateral plate mesoderm |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 1 | INHERITED FROM: neural crest || neuroectoderm |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
52058,49265,49265
52058 - L domain-like
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
63737,55486,48371
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | Direct |
57196,57196,49899
57196 - EGF/Laminin
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
53300,81995,81811
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0 | Direct |
54768,54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
46565,57938,49493
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
103647,103647,49899
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
81995,81811,82754
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
142921,47587,56399
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | Direct |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
47220,47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
47769,47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | Direct |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | Direct |
90229,90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | Direct |
57184,52058,49265
57184 - Growth factor receptor domain
52058 - L domain-like
49265 - Fibronectin type III | 0 | Direct |
49899,48726,49265
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | Direct |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
51230,47005,52777
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | Direct |
103647,103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | Direct |
46966,46966,47473
46966 - Spectrin repeat
46966 - Spectrin repeat
47473 - EF-hand | 0 | Direct |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.0299 | Inherited |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0.04695 | Inherited |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0.07311 | Inherited |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.1102 | Inherited |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0.1121 | Inherited |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.1702 | Inherited |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.3054 | Inherited |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.3214 | Inherited |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.61 | Inherited |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.8763 | Inherited |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 1 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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