Xenopus ANatomical entity (XAN): cell

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: XA Hierarchy (Xenopus anatomy and development from Xenbase frog anatomy ontology)

Shortest distance to current term (+ for parents, - for children) XA term [XA ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + 2: Xenopus anatomical entity [XAO:0000000] <9>

+ 1: whole organism [XAO:0003004] <12> (461|598) (465|335|145)

+ 1: anatomical structure [XAO:0003000] <11> (577|733) (577|400|163)

0: cell [XAO:0003012] <71> (92|101) (93|35|16)

- 1: cell part [XAO:0004290] <40> (5|5) (5|2|0)

- 1: neuron [XAO:0003023] <19> (10|12) (11|3|1)

- 1: epithelial cell [XAO:0003249] <9> (4|5) (4|2|1)

- 1: germ cell [XAO:0000111] <9> (56|61) (58|22|10)

- 1: glial cell [XAO:0004308] <6> (0|0) (0|0|0)

- 1: stem cell [XAO:0003054] <6> (2|4) (2|0|0)

- 1: ciliated cell [XAO:0005017] <5> (3|6) (3|1|0)

- 1: progenitor cell [XAO:0005033] <5> (2|4) (2|1|0)

- 1: zygote [XAO:0000035] <5> (0|0) (0|0|0)

- 1: early embryonic cell [XAO:0003241] <3> (3|4) (3|1|0)

- 1: lymphocyte [XAO:0003155] <3> (0|0) (0|0|0)

- 1: myocyte [XAO:0004475] <3> (3|2) (3|1|0)

- 1: pigment cell [XAO:0003014] <3> (2|2) (2|0|0)

- 1: circulating cell [XAO:0003239] <2> (0|0) (0|0|0)

- 1: endocrine cell [XAO:0003247] <2> (0|0) (0|0|0)

- 1: eye photoreceptor cell [XAO:0004110] <2> (0|2) (0|0|0)

- 1: myoblast [XAO:0003015] <2> (1|1) (1|0|0)

- 1: thrombocyte [XAO:0005266] <2> (0|0) (0|0|0)

- 1: keratin accumulating cell [XAO:0003252] <1> (0|0) (0|0|0)

- 1: mesodermal cell [XAO:0003255] <1> (3|3) (3|0|0)

- 1: migratory neural crest cell [XAO:0004069] <1> (0|1) (0|1|0)

- 1: pericyte [XAO:0003264] <1> (0|0) (0|0|0)

- 1: stromal cell [XAO:0005020] <1> (0|0) (0|0|0)

- 1: Merkel cell [XAO:0003254] (0|0) (0|0|0)

- 1: absorptive cell [XAO:0003231] (0|0) (0|0|0)

- 1: acid secreting cell [XAO:0003232] (0|0) (0|0|0)

- 1: acinar cell [XAO:0003233] (0|0) (0|0|0)

- 1: alkali secreting cell [XAO:0003234] (0|0) (0|0|0)

- 1: angioblast [XAO:0004163] (0|0) (0|0|0)

- 1: apoptotic cell [XAO:0004501] (0|0) (0|0|0)

- 1: barrier cell [XAO:0003235] (0|0) (0|0|0)

- 1: barrier epithelial cell [XAO:0003236] (0|0) (0|0|0)

- 1: cementoblast [XAO:0003237] (0|0) (0|0|0)

- 1: chondroblast [XAO:0003238] (0|0) (0|0|0)

- 1: chondrocyte [XAO:0003205] (0|0) (0|0|0)

- 1: digestive enzyme secreting cell [XAO:0003240] (0|0) (0|0|0)

- 1: ectodermal cell [XAO:0003245] (0|0) (0|0|0)

- 1: electrically active cell [XAO:0003246] (0|0) (0|0|0)

- 1: endodermal cell [XAO:0003248] (0|0) (0|0|0)

- 1: endothelial cell [XAO:0004149] (0|0) (0|0|0)

- 1: epicardial precursor cell [XAO:0004482] (0|0) (0|0|0)

- 1: erythroid cell [XAO:0004150] (1|1) (1|0|0)

- 1: exocrine cell [XAO:0003250] (0|0) (0|0|0)

- 1: follicle cell [XAO:0000230] (0|0) (0|0|0)

- 1: hatching gland cell [XAO:0003251] (0|0) (0|0|0)

- 1: hemangioblast [XAO:0004146] (1|1) (1|0|0)

- 1: ligament cell [XAO:0003253] (0|0) (0|0|0)

- 1: melanoblast [XAO:0004510] (0|0) (0|0|0)

- 1: melanotrope [XAO:0005116] (0|0) (0|0|0)

- 1: migrating neuroblast [XAO:0004272] (0|0) (0|0|0)

- 1: mitotic cell [XAO:0004502] (0|0) (0|0|0)

- 1: mucus secreting cell [XAO:0003256] (0|0) (0|0|0)

- 1: multiciliated cell precursor [XAO:0005180] (0|0) (0|0|0)

- 1: myelin accumulating cell [XAO:0003257] (0|0) (0|0|0)

- 1: myeloid cell [XAO:0004148] (0|1) (0|0|0)

- 1: neuromast mantle cell [XAO:0003258] (0|0) (0|0|0)

- 1: neuromast support cell [XAO:0003259] (0|0) (0|0|0)

- 1: nucleate erythrocyte [XAO:0003260] (0|0) (0|0|0)

- 1: olfactory epithelial support cell [XAO:0003261] (0|0) (0|0|0)

- 1: osteoblast [XAO:0004507] (0|0) (0|0|0)

- 1: oxygen accumulating cell [XAO:0003262] (0|0) (0|0|0)

- 1: paracrine cell [XAO:0003263] (0|0) (0|0|0)

- 1: perichondrial cell [XAO:0004315] (0|0) (0|0|0)

- 1: pial cell [XAO:0005288] (0|0) (0|0|0)

- 1: podocyte [XAO:0003206] (0|0) (0|0|0)

- 1: polar body [XAO:0000262] (0|0) (0|0|0)

- 1: postmigratory neural crest cell [XAO:0004309] (1|1) (1|1|0)

- 1: premigratory neural crest cell [XAO:0004522] (0|0) (0|0|0)

- 1: secondary myofiber [XAO:0005077] (0|0) (0|0|0)

- 1: skeletal muscle satellite cell [XAO:0005043] (0|0) (0|0|0)

- 1: small secretory cell [XAO:0005234] (0|0) (0|0|0)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)

SCOP term	FDR (all)	Annotation (direct or inherited)
Nucleoplasmin-like core domain	0	Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	Direct
LysM domain	0	Direct
C-terminal domain of adenylylcyclase associated protein	0	Direct
Translation proteins SH3-like domain	0	Direct
PAH2 domain	0	Direct
DnaJ/Hsp40 cysteine-rich domain	0	Direct
RBP11-like subunits of RNA polymerase	0	Direct
L-aspartase-like	0	Direct
USP8 N-terminal domain-like	0	Direct
E2F-DP heterodimerization region	0	Direct
Tim10-like	0	Direct
Moesin tail domain	0	Direct
Cu,Zn superoxide dismutase-like	0	Direct
Mediator hinge subcomplex-like	0	Direct
Nucleoporin domain	0	Direct
Isocitrate/Isopropylmalate dehydrogenase-like	0	Direct
FAD-dependent thiol oxidase	0	Direct
GINS helical bundle-like	0	Direct
Transcription factor IIA (TFIIA), beta-barrel domain	0	Direct
PriA/YqbF domain	0	Direct
alpha-catenin/vinculin-like	0	Direct
DNA ligase/mRNA capping enzyme, catalytic domain	0	Direct
Ribulose-phoshate binding barrel	0	Direct
Cysteine alpha-hairpin motif	0	Direct
Zn-binding ribosomal proteins	0	Direct
Subunits of heterodimeric actin filament capping protein Capz	0	Direct
Restriction endonuclease-like	0	Direct
Cryptochrome/photolyase FAD-binding domain	0	Direct
Translational machinery components	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	Direct
Cryptochrome/photolyase, N-terminal domain	0	Direct
PLP-binding barrel	0	Direct
Surp module (SWAP domain)	0	Direct
SPOC domain-like	0	Direct
LexA/Signal peptidase	0	Direct
The spindle assembly checkpoint protein mad2	0	Direct
SIS domain	0	Direct
PABC (PABP) domain	0	Direct
TK C-terminal domain-like	0	Direct
Myosin phosphatase inhibitor 17kDa protein, CPI-17	0	Direct
BSD domain-like	0	Direct
G protein-binding domain	0	Direct
Uracil-DNA glycosylase-like	0	Direct
ATP-dependent DNA ligase DNA-binding domain	0	Direct
Zn-finger domain of Sec23/24	0	Direct
Alanine racemase C-terminal domain-like	0	Direct
DLC	0	Direct
Nop domain	0	Direct
LuxS/MPP-like metallohydrolase	0	Direct
Ribosomal protein L10-like	0	Direct
Ribosomal proteins S24e, L23 and L15e	0	Direct
eIF1-like	0	Direct
Di-copper centre-containing domain	0	Direct
Transcription factor IIA (TFIIA), alpha-helical domain	0	Direct
RNA-binding domain, RBD	0.000000000004853	Direct
Nucleic acid-binding proteins	0.00002837	Direct
Sm-like ribonucleoproteins	0.0001312	Direct
CCCH zinc finger	0.0004922	Direct
ARM repeat	0.0007097	Direct
P-loop containing nucleoside triphosphate hydrolases	0.000773	Direct
SAP domain	0.000828	Direct
Tubulin C-terminal domain-like	0.002096	Inherited
S-adenosyl-L-methionine-dependent methyltransferases	0.003199	Inherited
Cyclin-like	0.003389	Inherited
Tubulin nucleotide-binding domain-like	0.00672	Inherited
Transducin (alpha subunit), insertion domain	0.008586	Inherited
UBC-like	0.009526	Inherited
"Winged helix" DNA-binding domain	0.03294	Inherited
Actin-like ATPase domain	0.04075	Inherited
14-3-3 protein	0.05777	Inherited
Translation proteins	0.0644	Inherited
Globin-like	0.1057	Inherited
HLH, helix-loop-helix DNA-binding domain	0.1355	Inherited
Intermediate filament protein, coiled coil region	0.3491	Inherited
SMAD MH1 domain	0.4341	Inherited
Spectrin repeat	0.7468	Inherited
p53-like transcription factors	0.8612	Inherited
Hemopexin-like domain	0.8985	Inherited
Tropomyosin	0.9347	Inherited
FnI-like domain	0.9403	Inherited
Voltage-gated potassium channels	1	Inherited
Homeodomain-like	1	Inherited
lambda repressor-like DNA-binding domains	1	Inherited
EF-hand	1	Inherited
POZ domain	1	Inherited
Cystine-knot cytokines	1	Inherited
Metalloproteases ("zincins"), catalytic domain	1	Inherited
Family A G protein-coupled receptor-like	1	Inherited
Integrin domains	1	Inherited
EGF/Laminin	1	Inherited

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Family

(show details)

SCOP term	FDR (all)	Annotation (direct or inherited)
Translation initiation factor eIF4e	0	Direct
Ferritin	0	Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0	Direct
eIF1-like	0	Direct
NTF2-like	0	Direct
PABC (PABP) domain	0	Direct
E2F dimerization segment	0	Direct
FAD-dependent thiol oxidase	0	Direct
Protein-L-isoaspartyl O-methyltransferase	0	Direct
Methyl-CpG-binding domain, MBD	0	Direct
Cryptochrome/photolyase FAD-binding domain	0	Direct
TRASH domain	0	Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	Direct
DNA ligase	0	Direct
Transcription factor IIA (TFIIA), beta-barrel domain	0	Direct
Zn-finger domain of Sec23/24	0	Direct
MPP-like	0	Direct
Alpha-adaptin ear subdomain-like	0	Direct
Sedlin (SEDL)	0	Direct
DNA ligase/mRNA capping enzyme postcatalytic domain	0	Direct
ATP-dependent DNA ligase catalytic domain	0	Direct
DLC	0	Direct
Variant RING domain	0	Direct
Nucleoplasmin-like core domain	0	Direct
Alanine racemase-like, N-terminal domain	0	Direct
Hypoxia-inducible factor HIF ihhibitor (FIH1)	0	Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	Direct
USP8 N-terminal domain-like	0	Direct
Dimeric isocitrate & isopropylmalate dehydrogenases	0	Direct
C-terminal domain of adenylylcyclase associated protein	0	Direct
Arrestin/Vps26-like	0	Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	Direct
Moesin tail domain	0	Direct
CAT-like	0	Direct
Eukaryotic ODC-like	0	Direct
TATA-box binding protein (TBP), C-terminal domain	0	Direct
Tim10/DDP	0	Direct
Protein prenyltransferases	0	Direct
PAH2 domain	0	Direct
alpha-catenin/vinculin	0	Direct
A20-like zinc finger	0	Direct
Ribosomal protein L18 and S11	0	Direct
Pseudouridine synthase I TruA	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
BSD domain	0	Direct
Phosphoribosylpyrophosphate synthetase-like	0	Direct
Cryptochrome/photolyase, N-terminal domain	0	Direct
Steroid-binding domain	0	Direct
Ran-binding domain	0	Direct
S-adenosylhomocystein hydrolase	0	Direct
Nop domain	0	Direct
LysM domain	0	Direct
Cu,Zn superoxide dismutase-like	0	Direct
Surp module (SWAP domain)	0	Direct
Transcription factor IIA (TFIIA), alpha-helical domain	0	Direct
Myosin phosphatase inhibitor 17kDa protein, CPI-17	0	Direct
DnaJ/Hsp40 cysteine-rich domain	0	Direct
XPF/Rad1/Mus81 nuclease	0	Direct
Clathrin adaptor appendage, alpha and beta chain-specific domain	0	Direct
B56-like	0	Direct
Canonical RBD	0.000000000003536	Direct
Cyclin	0.00006825	Direct
UBC-related	0.00008443	Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP	0.0001447	Direct
CCCH zinc finger	0.0003694	Direct
SAP domain	0.0006268	Direct
Tubulin, GTPase domain	0.001604	Inherited
Tubulin, C-terminal domain	0.001604	Inherited
ARID domain	0.002089	Inherited
WD40-repeat	0.002118	Inherited
Cold shock DNA-binding domain-like	0.005111	Inherited
Transducin (alpha subunit), insertion domain	0.006707	Inherited
Tudor domain	0.006707	Inherited
G proteins	0.008114	Inherited
Actin/HSP70	0.01706	Inherited
Elongation factors	0.03481	Inherited
14-3-3 protein	0.04781	Inherited
ets domain	0.07123	Inherited
Globins	0.08995	Inherited
HLH, helix-loop-helix DNA-binding domain	0.117	Inherited
Erythroid transcription factor GATA-1	0.1507	Inherited
SMAD domain	0.2885	Inherited
Intermediate filament protein, coiled coil region	0.3201	Inherited
SMAD MH1 domain	0.4011	Inherited
POU-specific domain	0.4828	Inherited
Paired domain	0.5637	Inherited
Spectrin repeat	0.6192	Inherited
Enabled/VASP homology 1 domain (EVH1 domain)	0.705	Inherited
Matrix metalloproteases, catalytic domain	0.7066	Inherited
Tropomyosin	0.7078	Inherited
Phosphotyrosine-binding domain (PTB)	0.7761	Inherited
T-box	0.8052	Inherited
Hemopexin-like domain	0.8684	Inherited
Forkhead DNA-binding domain	0.9565	Inherited
Integrin domains	0.9923	Inherited
Homeodomain	1	Inherited
Calmodulin-like	1	Inherited
Transforming growth factor (TGF)-beta	1	Inherited
Rhodopsin-like	1	Inherited
Voltage-gated potassium channels	1	Inherited
Tetramerization domain of potassium channels	1	Inherited

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Zn-binding ribosomal proteins	0	Direct
PABC (PABP) domain	0	Direct
PLP-binding barrel	0	Direct
Surp module (SWAP domain)	0	Direct
LexA/Signal peptidase	0	Direct
Restriction endonuclease-like	0	Direct
Zn-finger domain of Sec23/24	0	Direct
LuxS/MPP-like metallohydrolase	0	Direct
Nop domain	0	Direct
DnaJ/Hsp40 cysteine-rich domain	0	Direct
Mediator hinge subcomplex-like	0	Direct
Cryptochrome/photolyase FAD-binding domain	0	Direct
SPOC domain-like	0	Direct
Nucleoplasmin-like core domain	0	Direct
SIS domain	0	Direct
Cryptochrome/photolyase, N-terminal domain	0	Direct
Myosin phosphatase inhibitor 17kDa protein, CPI-17	0	Direct
TK C-terminal domain-like	0	Direct
Transcription factor IIA (TFIIA), beta-barrel domain	0	Direct
GINS helical bundle-like	0	Direct
LysM domain	0	Direct
ATP-dependent DNA ligase DNA-binding domain	0	Direct
Moesin tail domain	0	Direct
eIF1-like	0	Direct
E2F-DP heterodimerization region	0	Direct
USP8 N-terminal domain-like	0	Direct
DLC	0	Direct
alpha-catenin/vinculin-like	0	Direct
L-aspartase-like	0	Direct
G protein-binding domain	0	Direct
Subunits of heterodimeric actin filament capping protein Capz	0	Direct
Uracil-DNA glycosylase-like	0	Direct
Isocitrate/Isopropylmalate dehydrogenase-like	0	Direct
Di-copper centre-containing domain	0	Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	Direct
Translational machinery components	0	Direct
BSD domain-like	0	Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
Cu,Zn superoxide dismutase-like	0	Direct
Nucleoporin domain	0	Direct
The spindle assembly checkpoint protein mad2	0	Direct
Transcription factor IIA (TFIIA), alpha-helical domain	0	Direct
PAH2 domain	0	Direct
RBP11-like subunits of RNA polymerase	0	Direct
Tim10-like	0	Direct
Cysteine alpha-hairpin motif	0	Direct
DNA ligase/mRNA capping enzyme, catalytic domain	0	Direct
Ribosomal protein L10-like	0	Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	Direct
C-terminal domain of adenylylcyclase associated protein	0	Direct
Ribulose-phoshate binding barrel	0	Direct
Translation proteins SH3-like domain	0	Direct
Ribosomal proteins S24e, L23 and L15e	0	Direct
Alanine racemase C-terminal domain-like	0	Direct
FAD-dependent thiol oxidase	0	Direct
PriA/YqbF domain	0	Direct
RNA-binding domain, RBD	0.000000000003373	Direct
Nucleic acid-binding proteins	0.00002064	Direct
Sm-like ribonucleoproteins	0.00009708	Direct
CCCH zinc finger	0.0003702	Direct
ARM repeat	0.0005358	Direct
P-loop containing nucleoside triphosphate hydrolases	0.0005848	Direct
SAP domain	0.0006268	Direct
Tubulin C-terminal domain-like	0.001605	Inherited
ARID-like	0.002083	Inherited
S-adenosyl-L-methionine-dependent methyltransferases	0.002458	Inherited
Cyclin-like	0.002606	Inherited
Tubulin nucleotide-binding domain-like	0.005237	Inherited
Transducin (alpha subunit), insertion domain	0.006708	Inherited
UBC-like	0.007462	Inherited
"Winged helix" DNA-binding domain	0.02657	Inherited
Actin-like ATPase domain	0.03324	Inherited
14-3-3 protein	0.0477	Inherited
Translation proteins	0.05328	Inherited
Globin-like	0.08969	Inherited
HLH, helix-loop-helix DNA-binding domain	0.1172	Inherited
Intermediate filament protein, coiled coil region	0.3186	Inherited
SMAD MH1 domain	0.4008	Inherited
Spectrin repeat	0.7123	Inherited
p53-like transcription factors	0.8312	Inherited
Hemopexin-like domain	0.8696	Inherited
Tropomyosin	0.9068	Inherited
FnI-like domain	0.9115	Inherited
lambda repressor-like DNA-binding domains	0.9798	Inherited
Integrin domains	0.9902	Inherited
Cystine-knot cytokines	1	Inherited
EGF/Laminin	1	Inherited
Family A G protein-coupled receptor-like	1	Inherited
Metalloproteases ("zincins"), catalytic domain	1	Inherited
Voltage-gated potassium channels	1	Inherited
EF-hand	1	Inherited
Homeodomain-like	1	Inherited
POZ domain	1	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
51206,51206 51206 - cAMP-binding domain-like 51206 - cAMP-binding domain-like	0	Direct
54236,57889 54236 - Ubiquitin-like 57889 - Cysteine-rich domain	0	Direct
63411,63411 63411 - LuxS/MPP-like metallohydrolase 63411 - LuxS/MPP-like metallohydrolase	0	Direct
117018,56091 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain	0	Direct
51419,50621 51419 - PLP-binding barrel 50621 - Alanine racemase C-terminal domain-like	0	Direct
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	Direct
52518,52922 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52922 - TK C-terminal domain-like	0	Direct
55945,55945 55945 - TATA-box binding protein-like 55945 - TATA-box binding protein-like	0	Direct
51230,47005 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	Direct
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	Direct
52425,48173 52425 - Cryptochrome/photolyase, N-terminal domain 48173 - Cryptochrome/photolyase FAD-binding domain	0	Direct
47005,52777 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases	0	Direct
52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain	0	Direct
47095,47095 47095 - HMG-box 47095 - HMG-box	0	Direct
57424,57184 57424 - LDL receptor-like module 57184 - Growth factor receptor domain	0	Direct
49899,48726 49899 - Concanavalin A-like lectins/glucanases 48726 - Immunoglobulin	0	Direct
47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like	0	Direct
56091,50249 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins	0	Direct
48371,46785 48371 - ARM repeat 46785 - "Winged helix" DNA-binding domain	0	Direct
57938,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain	0	Direct
46565,57938 46565 - Chaperone J-domain 57938 - DnaJ/Hsp40 cysteine-rich domain	0	Direct
57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0	Direct
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region	0	Direct
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like	0	Direct
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD	0.00000255	Direct
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like	0.000007624	Direct
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like	0.001605	Inherited
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0.006708	Inherited
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	0.007912	Inherited
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins	0.01357	Inherited
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.1261	Inherited
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat	0.6158	Inherited
50156,50156 50156 - PDZ domain-like 50156 - PDZ domain-like	0.8577	Inherited
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like	0.8848	Inherited
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	1	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
54791,54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I)	0	Direct
57938,49493,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain	0	Direct
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	Direct
57424,57424,57184 57424 - LDL receptor-like module 57424 - LDL receptor-like module 57184 - Growth factor receptor domain	0	Direct
103657,50729,48350 103657 - BAR/IMD domain-like 50729 - PH domain-like 48350 - GTPase activation domain, GAP	0	Direct
54768,54768,54768 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like	0	Direct
46565,57938,49493 46565 - Chaperone J-domain 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain	0	Direct
117018,56091,50249 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins	0	Direct
47220,47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like	0	Direct
50249,50249,50249 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins	0	Direct
90229,90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger 90229 - CCCH zinc finger	0	Direct
49899,48726,49265 49899 - Concanavalin A-like lectins/glucanases 48726 - Immunoglobulin 49265 - Fibronectin type III	0	Direct
51230,47005,52777 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases	0	Direct
57424,57184,63825 57424 - LDL receptor-like module 57184 - Growth factor receptor domain 63825 - YWTD domain	0	Direct
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat	0.2724	Inherited
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0.8949	Inherited

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Xenopus ANatomical entity (XAN): cell

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Supra-domain (including individual superfamily)