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Zebrafish Anatomy (ZA): anatomical system
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: ZA Hierarchy (zebrafish anatomy from ZFIN zebrafish anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this ZA term (Not in SDZA)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| F-box domain | 0 | DIRECT |
| HIT-like | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| Regulator of G-protein signaling, RGS | 0 | DIRECT |
| Translation proteins | 0 | DIRECT |
| Caspase-like | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| Phoshotransferase/anion transport protein | 0 | DIRECT |
| Plexin repeat | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| Zinc beta-ribbon | 0 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| Tropomyosin | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| Class II aaRS and biotin synthetases | 0 | DIRECT |
| LDL receptor-like module | 0 | DIRECT |
| Rhodanese/Cell cycle control phosphatase | 0 | DIRECT |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
| L27 domain | 0 | DIRECT |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | DIRECT |
| BRCT domain | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
| Bet v1-like | 0 | DIRECT |
| Calcium ATPase, transmembrane domain M | 0 | DIRECT |
| PLP-dependent transferases | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| Translation proteins SH3-like domain | 0 | DIRECT |
| Ypt/Rab-GAP domain of gyp1p | 0 | DIRECT |
| Ricin B-like lectins | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| CoA-dependent acyltransferases | 0 | DIRECT |
| SMAD/FHA domain | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| UBA-like | 0 | DIRECT |
| RCC1/BLIP-II | 0 | DIRECT |
| Galactose-binding domain-like | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| LCCL domain | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| CCCH zinc finger | 0 | DIRECT |
| Soluble quinoprotein glucose dehydrogenase | 0 | DIRECT |
| Kringle-like | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Hemopexin-like domain | 0 | DIRECT |
| Myosin rod fragments | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| ENTH/VHS domain | 0 | DIRECT |
| Cupredoxins | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| FAD-linked reductases, C-terminal domain | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| Orange domain-like | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| TSP-1 type 1 repeat | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| BPTI-like | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| Calcium ATPase, transduction domain A | 0 | DIRECT |
| SH2 domain | 0 | DIRECT |
| Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
| Nucleotidylyl transferase | 0 | DIRECT |
| DPP6 N-terminal domain-like | 0 | DIRECT |
| Cullin repeat-like | 0 | DIRECT |
| CAD & PB1 domains | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| Metallo-dependent hydrolases | 0 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| SNARE-like | 0 | DIRECT |
| SET domain | 0 | DIRECT |
| Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| CalX-like | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| Alkaline phosphatase-like | 0 | DIRECT |
| alpha/beta-Hydrolases | 0 | DIRECT |
| Leucine zipper domain | 0 | DIRECT |
| STAT | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| GTPase activation domain, GAP | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| Nucleotide cyclase | 0 | DIRECT |
| Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
| POZ domain | 0 | DIRECT |
| Ras GEF | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| SNARE fusion complex | 0 | DIRECT |
| Riboflavin synthase domain-like | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Cyclin-like | 0 | DIRECT |
| HSP20-like chaperones | 0 | DIRECT |
| Immunoglobulin | 0.02161 | INHERITED FROM: medial longitudinal fasciculus || olfactory bulb glomerulus || white matter |
| Homeodomain-like | 0.05352 | INHERITED FROM: endocrine pancreas || cephalic musculature || endocrine cell || diencephalon || preoptic area || forebrain |
| WD40 repeat-like | 0.06864 | INHERITED FROM: retinal outer nuclear layer || photoreceptor outer segment layer |
| Cystine-knot cytokines | 0.09064 | INHERITED FROM: spermatogenic cyst |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.1266 | INHERITED FROM: cardiac ventricle || VeLD || Kolmer-Agduhr neuron |
| Growth factor receptor domain | 0.1319 | INHERITED FROM: blood plasma || posterior lateral line ganglion || intramembranous bone || blood vasculature || lymphatic system |
| Nuclear receptor ligand-binding domain | 0.1414 | INHERITED FROM: gonad || ovarian follicle stage IV || hypophysis || reproductive system |
| EGF/Laminin | 0.2184 | INHERITED FROM: vasculature || posterior lateral line ganglion || lateral line ganglion || pars superior ear || lymph vessel || blood vasculature || lymphatic system |
| C-type lectin-like | 0.3149 | INHERITED FROM: axial vasculature || lymph vessel || lymphatic system |
| FnI-like domain | 0.3149 | INHERITED FROM: skeletal system || palatoquadrate cartilage || replacement bone || chondral bone || skeletal element || palatoquadrate arch |
| Fibronectin type III | 0.3457 | INHERITED FROM: glomerular layer || medial longitudinal fasciculus || synencephalon || white matter |
| DEATH domain | 0.4195 | INHERITED FROM: blood vasculature |
| Bromodomain | 0.4486 | INHERITED FROM: blood || hematopoietic system |
| lambda repressor-like DNA-binding domains | 0.5165 | INHERITED FROM: digestive system duct || diencephalon |
| Snake toxin-like | 0.5165 | INHERITED FROM: axial vasculature |
| Tudor/PWWP/MBT | 0.553 | INHERITED FROM: reproductive system || primordial germ cell |
| Cytokine | 0.553 | INHERITED FROM: dermatocranium || olfactory region || intramembranous bone |
| beta-beta-alpha zinc fingers | 0.5548 | INHERITED FROM: ventral thalamus |
| p53-like transcription factors | 0.5735 | INHERITED FROM: primordial vasculature |
| Cadherin-like | 0.5837 | INHERITED FROM: cranial nerve || diencephalic white matter || optic tectum || white matter || cranial nerve II |
| HLH, helix-loop-helix DNA-binding domain | 0.5951 | INHERITED FROM: heart primordium || Kolmer-Agduhr neuron |
| GroEL-intermediate domain like | 0.6371 | INHERITED FROM: skeletal muscle || trunk musculature || myotome || musculature system || skeletal muscle cell || muscle cell || striated muscle cell |
| Protease propeptides/inhibitors | 0.6371 | INHERITED FROM: optic tectum |
| Multidrug efflux transporter AcrB transmembrane domain | 0.6371 | INHERITED FROM: skeletal muscle || retinal ganglion cell layer || dorsal hyoid arch || skeletal muscle cell || hyosymplectic cartilage || striated muscle cell |
| PDZ domain-like | 0.7163 | INHERITED FROM: central canal |
| BAR/IMD domain-like | 0.7245 | INHERITED FROM: olfactory system |
| Retrovirus zinc finger-like domains | 0.7297 | INHERITED FROM: gill || pharyngeal arch 3-7 || respiratory system |
| ACT-like | 0.7297 | INHERITED FROM: axial blood vessel || ventral wall of dorsal aorta || artery || dorsal aorta |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7297 | INHERITED FROM: axial blood vessel || ventral wall of dorsal aorta || artery || dorsal aorta |
| HMG-box | 0.7523 | INHERITED FROM: ganglion || vagal ganglion || statoacoustic (VIII) ganglion || dorsal root ganglion |
| DBL homology domain (DH-domain) | 0.7524 | INHERITED FROM: blood vessel endothelium || blood vessel endothelial cell || vascular endothelium |
| Serine protease inhibitors | 0.7806 | INHERITED FROM: vestibuloauditory system || inner ear || otolith organ || otolith |
| IP3 receptor type 1 binding core, domain 2 | 0.7806 | INHERITED FROM: skeletal muscle || skeletal muscle cell || muscle cell || striated muscle cell |
| NAD(P)-binding Rossmann-fold domains | 0.817 | INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer |
| GroEL equatorial domain-like | 0.8416 | INHERITED FROM: skeletal muscle || trunk musculature || myotome || skeletal muscle cell || muscle cell || striated muscle cell |
| GroEL apical domain-like | 0.8732 | INHERITED FROM: skeletal muscle || trunk musculature || myotome || skeletal muscle cell || muscle cell || striated muscle cell |
| Cysteine proteinases | 0.8923 | INHERITED FROM: ethmoid cartilage || skeletal system || pharyngeal arch cartilage || chondrocranium cartilage || olfactory region || splanchnocranium || cartilage element || chondrocranium || skeletal element || neurocranium || ventral mandibular arch || mandibular arch skeleton |
| MIR domain | 1 | INHERITED FROM: skeletal muscle cell |
| Cytochrome P450 | 1 | INHERITED FROM: hypophysis |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| F-box domain | 0 | Direct |
| HIT-like | 0 | Direct |
| ALDH-like | 0 | Direct |
| Integrin domains | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| ADC-like | 0 | Direct |
| Connexin43 | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| Tubulin nucleotide-binding domain-like | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| Regulator of G-protein signaling, RGS | 0 | Direct |
| Translation proteins | 0 | Direct |
| Caspase-like | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| Phoshotransferase/anion transport protein | 0 | Direct |
| Plexin repeat | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| Zinc beta-ribbon | 0 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| Tropomyosin | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| Class II aaRS and biotin synthetases | 0 | Direct |
| LDL receptor-like module | 0 | Direct |
| Rhodanese/Cell cycle control phosphatase | 0 | Direct |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
| L27 domain | 0 | Direct |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | Direct |
| BRCT domain | 0 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
| Bet v1-like | 0 | Direct |
| Calcium ATPase, transmembrane domain M | 0 | Direct |
| PLP-dependent transferases | 0 | Direct |
| PP2C-like | 0 | Direct |
| NTF2-like | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| Translation proteins SH3-like domain | 0 | Direct |
| Ypt/Rab-GAP domain of gyp1p | 0 | Direct |
| Ricin B-like lectins | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Plakin repeat | 0 | Direct |
| CoA-dependent acyltransferases | 0 | Direct |
| SMAD/FHA domain | 0 | Direct |
| Translational machinery components | 0 | Direct |
| UBA-like | 0 | Direct |
| RCC1/BLIP-II | 0 | Direct |
| Galactose-binding domain-like | 0 | Direct |
| CCHHC domain | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| SRF-like | 0 | Direct |
| LCCL domain | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| Ribosomal protein S5 domain 2-like | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| CCCH zinc finger | 0 | Direct |
| Soluble quinoprotein glucose dehydrogenase | 0 | Direct |
| Kringle-like | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Hemopexin-like domain | 0 | Direct |
| Myosin rod fragments | 0 | Direct |
| PGBD-like | 0 | Direct |
| ENTH/VHS domain | 0 | Direct |
| Cupredoxins | 0 | Direct |
| Sec7 domain | 0 | Direct |
| FAD-linked reductases, C-terminal domain | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| Orange domain-like | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| Tricorn protease domain 2 | 0 | Direct |
| TSP-1 type 1 repeat | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| BPTI-like | 0 | Direct |
| SAICAR synthase-like | 0 | Direct |
| GLA-domain | 0 | Direct |
| Calcium ATPase, transduction domain A | 0 | Direct |
| SH2 domain | 0 | Direct |
| Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
| Nucleotidylyl transferase | 0 | Direct |
| DPP6 N-terminal domain-like | 0 | Direct |
| Cullin repeat-like | 0 | Direct |
| CAD & PB1 domains | 0 | Direct |
| Polo-box domain | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| Metallo-dependent hydrolases | 0 | Direct |
| Nicotinic receptor ligand binding domain-like | 0 | Direct |
| Aldolase | 0 | Direct |
| SNARE-like | 0 | Direct |
| SET domain | 0 | Direct |
| Glutathione synthetase ATP-binding domain-like | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| CalX-like | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Composite domain of metallo-dependent hydrolases | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| Alkaline phosphatase-like | 0 | Direct |
| alpha/beta-Hydrolases | 0 | Direct |
| Leucine zipper domain | 0 | Direct |
| STAT | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| GTPase activation domain, GAP | 0 | Direct |
| Sema domain | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| Nucleotide cyclase | 0 | Direct |
| Formin homology 2 domain (FH2 domain) | 0 | Direct |
| POZ domain | 0 | Direct |
| Ras GEF | 0 | Direct |
| Notch domain | 0 | Direct |
| SNARE fusion complex | 0 | Direct |
| Riboflavin synthase domain-like | 0 | Direct |
| FAS1 domain | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Cyclin-like | 0 | Direct |
| HSP20-like chaperones | 0 | Direct |
| Immunoglobulin | 0.02161 | Inherited |
| Homeodomain-like | 0.05352 | Inherited |
| WD40 repeat-like | 0.06864 | Inherited |
| Cystine-knot cytokines | 0.09064 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.1266 | Inherited |
| Growth factor receptor domain | 0.1319 | Inherited |
| Nuclear receptor ligand-binding domain | 0.1414 | Inherited |
| EGF/Laminin | 0.2184 | Inherited |
| C-type lectin-like | 0.3149 | Inherited |
| FnI-like domain | 0.3149 | Inherited |
| Fibronectin type III | 0.3457 | Inherited |
| DEATH domain | 0.4195 | Inherited |
| Bromodomain | 0.4486 | Inherited |
| lambda repressor-like DNA-binding domains | 0.5165 | Inherited |
| Snake toxin-like | 0.5165 | Inherited |
| Tudor/PWWP/MBT | 0.553 | Inherited |
| Cytokine | 0.553 | Inherited |
| beta-beta-alpha zinc fingers | 0.5548 | Inherited |
| p53-like transcription factors | 0.5735 | Inherited |
| Cadherin-like | 0.5837 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.5951 | Inherited |
| GroEL-intermediate domain like | 0.6371 | Inherited |
| Protease propeptides/inhibitors | 0.6371 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.6371 | Inherited |
| PDZ domain-like | 0.7163 | Inherited |
| BAR/IMD domain-like | 0.7245 | Inherited |
| Retrovirus zinc finger-like domains | 0.7297 | Inherited |
| ACT-like | 0.7297 | Inherited |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7297 | Inherited |
| HMG-box | 0.7523 | Inherited |
| DBL homology domain (DH-domain) | 0.7524 | Inherited |
| Serine protease inhibitors | 0.7806 | Inherited |
| IP3 receptor type 1 binding core, domain 2 | 0.7806 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 0.817 | Inherited |
| GroEL equatorial domain-like | 0.8416 | Inherited |
| GroEL apical domain-like | 0.8732 | Inherited |
| Cysteine proteinases | 0.8923 | Inherited |
| MIR domain | 1 | Inherited |
| Cytochrome P450 | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this ZA term (Not in SDZA)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Matrix metalloproteases, catalytic domain | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| EF-hand modules in multidomain proteins | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | DIRECT |
| Elongation factors | 0 | DIRECT |
| UBA domain | 0 | DIRECT |
| Leucine zipper domain | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | DIRECT |
| Arrestin/Vps26-like | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| FAD-linked reductases, N-terminal domain | 0 | DIRECT |
| Platelet-derived growth factor-like | 0 | DIRECT |
| Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | DIRECT |
| Mammalian PLC | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| F-box domain | 0 | DIRECT |
| Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
| Extended AAA-ATPase domain | 0 | DIRECT |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| Ephrin receptor ligand binding domain | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Hydantoinase (dihydropyrimidinase) | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| SNARE fusion complex | 0 | DIRECT |
| L domain | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| Laminin G-like module | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| Tropomyosin | 0 | DIRECT |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | DIRECT |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0 | DIRECT |
| CalX-beta domain | 0 | DIRECT |
| LDL receptor-like module | 0 | DIRECT |
| MYND zinc finger | 0 | DIRECT |
| BAR domain | 0 | DIRECT |
| p120GAP domain-like | 0 | DIRECT |
| Eukaryotic proteases | 0 | DIRECT |
| L27 domain | 0 | DIRECT |
| Histone lysine methyltransferases | 0 | DIRECT |
| P4 origin-binding domain-like | 0 | DIRECT |
| Ephrin ectodomain | 0 | DIRECT |
| Cytoplasmic domain of inward rectifier potassium channel | 0 | DIRECT |
| Anion transport protein, cytoplasmic domain | 0 | DIRECT |
| V set domains (antibody variable domain-like) | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| 28-residue LRR | 0 | DIRECT |
| Clathrin coat assembly domain | 0 | DIRECT |
| Calmodulin-like | 0 | DIRECT |
| Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
| Adenylyl and guanylyl cyclase catalytic domain | 0 | DIRECT |
| Dual specificity phosphatase-like | 0 | DIRECT |
| Small Kunitz-type inhibitors & BPTI-like toxins | 0 | DIRECT |
| Tudor domain | 0 | DIRECT |
| Plexin repeat | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Paired domain | 0 | DIRECT |
| Calcium ATPase, transduction domain A | 0 | DIRECT |
| POU-specific domain | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| Caspase recruitment domain, CARD | 0 | DIRECT |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
| Histone deacetylase, HDAC | 0 | DIRECT |
| Myeloperoxidase-like | 0 | DIRECT |
| Tubulin, GTPase domain | 0 | DIRECT |
| RUNT domain | 0 | DIRECT |
| Noncollagenous (NC1) domain of collagen IV | 0 | DIRECT |
| Pyridoxal-dependent decarboxylase | 0 | DIRECT |
| CCCH zinc finger | 0 | DIRECT |
| PAPS sulfotransferase | 0 | DIRECT |
| Hairy Orange domain | 0 | DIRECT |
| Tubulin, C-terminal domain | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | DIRECT |
| STAT | 0 | DIRECT |
| Link domain | 0 | DIRECT |
| Fibronectin type II module | 0 | DIRECT |
| LCCL domain | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| Regulator of chromosome condensation RCC1 | 0 | DIRECT |
| Proprotein convertase P-domain | 0 | DIRECT |
| Reprolysin-like | 0 | DIRECT |
| Nucleotide and nucleoside kinases | 0 | DIRECT |
| Choline/Carnitine O-acyltransferase | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Troponin T | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) | 0 | DIRECT |
| Zf-UBP | 0 | DIRECT |
| Cyclin | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| Chromo domain | 0 | DIRECT |
| PB1 domain | 0 | DIRECT |
| Regulator of G-protein signaling, RGS | 0 | DIRECT |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | DIRECT |
| Dachshund-homology domain | 0 | DIRECT |
| SH2 domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Glycerophosphoryl diester phosphodiesterase | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| Subtilases | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Erythroid transcription factor GATA-1 | 0 | DIRECT |
| VWC domain | 0 | DIRECT |
| Tetramerization domain of potassium channels | 0 | DIRECT |
| Armadillo repeat | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| Meta-cation ATPase, catalytic domain P | 0 | DIRECT |
| Long-chain cytokines | 0 | DIRECT |
| Myotubularin-like phosphatases | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| Prohormone convertase 1 pro-domain | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Caspase catalytic domain | 0 | DIRECT |
| BTB/POZ domain | 0 | DIRECT |
| Ubiquitin-related | 0 | DIRECT |
| STAT DNA-binding domain | 0 | DIRECT |
| BCR-homology GTPase activation domain (BH-domain) | 0 | DIRECT |
| Clathrin adaptor core protein | 0 | DIRECT |
| Cell cycle transcription factor e2f-dp | 0 | DIRECT |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Ras GEF | 0 | DIRECT |
| Cdc48 N-terminal domain-like | 0 | DIRECT |
| FHA domain | 0 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
| GABA-aminotransferase-like | 0 | DIRECT |
| MMP N-terminal domain | 0 | DIRECT |
| TSP-1 type 1 repeat | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0 | DIRECT |
| Myosin rod fragments | 0 | DIRECT |
| Ovomucoid domain III-like | 0 | DIRECT |
| Single strand DNA-binding domain, SSB | 0 | DIRECT |
| Hemopexin-like domain | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | DIRECT |
| SWIRM domain | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| Calcium ATPase, transmembrane domain M | 0 | DIRECT |
| WD40-repeat | 0.01417 | INHERITED FROM: retinal cone cell || photoreceptor outer segment layer |
| Homeodomain | 0.03984 | INHERITED FROM: endocrine pancreas || dorsal telencephalon || pancreatic A cell || cephalic musculature || endocrine cell || diencephalon || preoptic area || forebrain |
| EGF-type module | 0.06649 | INHERITED FROM: posterior lateral line ganglion || lateral line ganglion || semicircular canal |
| I set domains | 0.068 | INHERITED FROM: medial longitudinal fasciculus || synencephalon || white matter |
| Motor proteins | 0.09833 | INHERITED FROM: renal corpuscle || pronephric podocyte || photoreceptor outer segment layer |
| Growth factor receptor domain | 0.1238 | INHERITED FROM: posterior semicircular canal |
| Nuclear receptor ligand-binding domain | 0.1238 | INHERITED FROM: gonad || ovarian follicle stage IV || hypophysis || reproductive system |
| Nuclear receptor | 0.1338 | INHERITED FROM: gonad || ovarian follicle stage IV || hypophysis || reproductive system |
| Transforming growth factor (TGF)-beta | 0.156 | INHERITED FROM: floor plate || spermatogenic cyst || pineal complex |
| LIM domain | 0.2901 | INHERITED FROM: cardiac ventricle |
| Fibronectin type III | 0.3291 | INHERITED FROM: glomerular layer || medial longitudinal fasciculus || synencephalon || white matter |
| Classic zinc finger, C2H2 | 0.3425 | INHERITED FROM: ventral thalamus || thalamus |
| Myb/SANT domain | 0.3916 | INHERITED FROM: granulocyte || neutrophil |
| Bromodomain | 0.4221 | INHERITED FROM: blood || hematopoietic system |
| Tetratricopeptide repeat (TPR) | 0.4828 | INHERITED FROM: retinal rod cell |
| Laminin-type module | 0.4893 | INHERITED FROM: slow muscle cell |
| Fibroblast growth factors (FGF) | 0.5275 | INHERITED FROM: dermatocranium || olfactory region || intramembranous bone |
| ets domain | 0.5275 | INHERITED FROM: granulocyte || myeloid leukocyte |
| PDZ domain | 0.5519 | INHERITED FROM: central canal |
| HLH, helix-loop-helix DNA-binding domain | 0.5766 | INHERITED FROM: heart primordium || Kolmer-Agduhr neuron |
| Cadherin | 0.588 | INHERITED FROM: nerve || cranial nerve || diencephalic white matter || optic tectum || white matter || cranial nerve II |
| Protein kinases, catalytic subunit | 0.6278 | INHERITED FROM: dorsal longitudinal anastomotic vessel |
| Retrovirus zinc finger-like domains | 0.7128 | INHERITED FROM: gill || pharyngeal arch 3-7 || pharynx || respiratory system |
| Phenylalanine metabolism regulatory domain | 0.7128 | INHERITED FROM: axial blood vessel || ventral wall of dorsal aorta || artery || dorsal aorta |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7128 | INHERITED FROM: axial blood vessel || ventral wall of dorsal aorta || artery || dorsal aorta |
| Multidrug efflux transporter AcrB transmembrane domain | 0.7128 | INHERITED FROM: skeletal muscle || retinal ganglion cell layer || suspensorium || dorsal hyoid arch || ventral hyoid arch || pharyngeal arch 2 skeleton || skeletal muscle cell || hyosymplectic cartilage || slow muscle cell |
| HMG-box | 0.7415 | INHERITED FROM: ganglion || vagal ganglion || statoacoustic (VIII) ganglion || dorsal root ganglion || ceratobranchial 5 bone |
| DBL homology domain (DH-domain) | 0.7416 | INHERITED FROM: blood vessel endothelium || blood vessel endothelial cell || vascular endothelium |
| T-box | 0.7416 | INHERITED FROM: primordial vasculature || atrioventricular canal || heart primordium || pronephros |
| WW domain | 0.7713 | INHERITED FROM: striated muscle cell |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.8009 | INHERITED FROM: ethmoid cartilage || pharyngeal arch cartilage || olfactory region || splanchnocranium || cartilage element || cranial cartilage || chondrocranium || skeletal element || neurocranium || ventral mandibular arch || mandibular arch skeleton |
| MIR domain | 1 | INHERITED FROM: skeletal muscle cell |
| Cytochrome P450 | 1 | INHERITED FROM: hypophysis |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Matrix metalloproteases, catalytic domain | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| SRF-like | 0 | Direct |
| EF-hand modules in multidomain proteins | 0 | Direct |
| GLA-domain | 0 | Direct |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | Direct |
| Elongation factors | 0 | Direct |
| UBA domain | 0 | Direct |
| Leucine zipper domain | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | Direct |
| Arrestin/Vps26-like | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| FAD-linked reductases, N-terminal domain | 0 | Direct |
| Platelet-derived growth factor-like | 0 | Direct |
| Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | Direct |
| Mammalian PLC | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| F-box domain | 0 | Direct |
| Formin homology 2 domain (FH2 domain) | 0 | Direct |
| Extended AAA-ATPase domain | 0 | Direct |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| Ephrin receptor ligand binding domain | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Hydantoinase (dihydropyrimidinase) | 0 | Direct |
| Sec7 domain | 0 | Direct |
| SNARE fusion complex | 0 | Direct |
| L domain | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| Laminin G-like module | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| Tropomyosin | 0 | Direct |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | Direct |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0 | Direct |
| CalX-beta domain | 0 | Direct |
| LDL receptor-like module | 0 | Direct |
| MYND zinc finger | 0 | Direct |
| BAR domain | 0 | Direct |
| p120GAP domain-like | 0 | Direct |
| Eukaryotic proteases | 0 | Direct |
| L27 domain | 0 | Direct |
| Histone lysine methyltransferases | 0 | Direct |
| P4 origin-binding domain-like | 0 | Direct |
| Ephrin ectodomain | 0 | Direct |
| Cytoplasmic domain of inward rectifier potassium channel | 0 | Direct |
| Anion transport protein, cytoplasmic domain | 0 | Direct |
| V set domains (antibody variable domain-like) | 0 | Direct |
| Sema domain | 0 | Direct |
| 28-residue LRR | 0 | Direct |
| Clathrin coat assembly domain | 0 | Direct |
| Calmodulin-like | 0 | Direct |
| Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
| Adenylyl and guanylyl cyclase catalytic domain | 0 | Direct |
| Dual specificity phosphatase-like | 0 | Direct |
| Small Kunitz-type inhibitors & BPTI-like toxins | 0 | Direct |
| Tudor domain | 0 | Direct |
| Plexin repeat | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Paired domain | 0 | Direct |
| Calcium ATPase, transduction domain A | 0 | Direct |
| POU-specific domain | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| Caspase recruitment domain, CARD | 0 | Direct |
| C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
| Histone deacetylase, HDAC | 0 | Direct |
| Myeloperoxidase-like | 0 | Direct |
| Tubulin, GTPase domain | 0 | Direct |
| RUNT domain | 0 | Direct |
| Noncollagenous (NC1) domain of collagen IV | 0 | Direct |
| Pyridoxal-dependent decarboxylase | 0 | Direct |
| CCCH zinc finger | 0 | Direct |
| PAPS sulfotransferase | 0 | Direct |
| Hairy Orange domain | 0 | Direct |
| Tubulin, C-terminal domain | 0 | Direct |
| CCHHC domain | 0 | Direct |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | Direct |
| STAT | 0 | Direct |
| Link domain | 0 | Direct |
| Fibronectin type II module | 0 | Direct |
| LCCL domain | 0 | Direct |
| Connexin43 | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| Regulator of chromosome condensation RCC1 | 0 | Direct |
| Proprotein convertase P-domain | 0 | Direct |
| Reprolysin-like | 0 | Direct |
| Nucleotide and nucleoside kinases | 0 | Direct |
| Choline/Carnitine O-acyltransferase | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| Nicotinic receptor ligand binding domain-like | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Troponin T | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| SMAD domain | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| FAS1 domain | 0 | Direct |
| Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) | 0 | Direct |
| Zf-UBP | 0 | Direct |
| Cyclin | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| Chromo domain | 0 | Direct |
| PB1 domain | 0 | Direct |
| Regulator of G-protein signaling, RGS | 0 | Direct |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | Direct |
| Dachshund-homology domain | 0 | Direct |
| SH2 domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Glycerophosphoryl diester phosphodiesterase | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| Subtilases | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Erythroid transcription factor GATA-1 | 0 | Direct |
| VWC domain | 0 | Direct |
| Tetramerization domain of potassium channels | 0 | Direct |
| Armadillo repeat | 0 | Direct |
| Plakin repeat | 0 | Direct |
| Meta-cation ATPase, catalytic domain P | 0 | Direct |
| Long-chain cytokines | 0 | Direct |
| Myotubularin-like phosphatases | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| Prohormone convertase 1 pro-domain | 0 | Direct |
| Integrin domains | 0 | Direct |
| Caspase catalytic domain | 0 | Direct |
| BTB/POZ domain | 0 | Direct |
| Ubiquitin-related | 0 | Direct |
| STAT DNA-binding domain | 0 | Direct |
| BCR-homology GTPase activation domain (BH-domain) | 0 | Direct |
| Clathrin adaptor core protein | 0 | Direct |
| Cell cycle transcription factor e2f-dp | 0 | Direct |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0 | Direct |
| ALDH-like | 0 | Direct |
| PP2C-like | 0 | Direct |
| Notch domain | 0 | Direct |
| Ras GEF | 0 | Direct |
| Cdc48 N-terminal domain-like | 0 | Direct |
| FHA domain | 0 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
| GABA-aminotransferase-like | 0 | Direct |
| MMP N-terminal domain | 0 | Direct |
| TSP-1 type 1 repeat | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0 | Direct |
| Myosin rod fragments | 0 | Direct |
| Ovomucoid domain III-like | 0 | Direct |
| Single strand DNA-binding domain, SSB | 0 | Direct |
| Hemopexin-like domain | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | Direct |
| SWIRM domain | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| Calcium ATPase, transmembrane domain M | 0 | Direct |
| WD40-repeat | 0.01417 | Inherited |
| Homeodomain | 0.03984 | Inherited |
| EGF-type module | 0.06649 | Inherited |
| I set domains | 0.068 | Inherited |
| Motor proteins | 0.09833 | Inherited |
| Growth factor receptor domain | 0.1238 | Inherited |
| Nuclear receptor ligand-binding domain | 0.1238 | Inherited |
| Nuclear receptor | 0.1338 | Inherited |
| Transforming growth factor (TGF)-beta | 0.156 | Inherited |
| LIM domain | 0.2901 | Inherited |
| Fibronectin type III | 0.3291 | Inherited |
| Classic zinc finger, C2H2 | 0.3425 | Inherited |
| Myb/SANT domain | 0.3916 | Inherited |
| Bromodomain | 0.4221 | Inherited |
| Tetratricopeptide repeat (TPR) | 0.4828 | Inherited |
| Laminin-type module | 0.4893 | Inherited |
| Fibroblast growth factors (FGF) | 0.5275 | Inherited |
| ets domain | 0.5275 | Inherited |
| PDZ domain | 0.5519 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.5766 | Inherited |
| Cadherin | 0.588 | Inherited |
| Protein kinases, catalytic subunit | 0.6278 | Inherited |
| Retrovirus zinc finger-like domains | 0.7128 | Inherited |
| Phenylalanine metabolism regulatory domain | 0.7128 | Inherited |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7128 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.7128 | Inherited |
| HMG-box | 0.7415 | Inherited |
| DBL homology domain (DH-domain) | 0.7416 | Inherited |
| T-box | 0.7416 | Inherited |
| WW domain | 0.7713 | Inherited |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.8009 | Inherited |
| MIR domain | 1 | Inherited |
| Cytochrome P450 | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this ZA term (Not in SPZA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| HSP20-like chaperones | 0 | DIRECT |
| LDL receptor-like module | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Nucleotidylyl transferase | 0 | DIRECT |
| Hemopexin-like domain | 0 | DIRECT |
| CoA-dependent acyltransferases | 0 | DIRECT |
| UBA-like | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| Ypt/Rab-GAP domain of gyp1p | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| SMAD/FHA domain | 0 | DIRECT |
| PLP-dependent transferases | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| ENTH/VHS domain | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| Alkaline phosphatase-like | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| HIT-like | 0 | DIRECT |
| Zinc beta-ribbon | 0 | DIRECT |
| Caspase-like | 0 | DIRECT |
| Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
| BPTI-like | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| Kringle-like | 0 | DIRECT |
| Soluble quinoprotein glucose dehydrogenase | 0 | DIRECT |
| Plexin repeat | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| SET domain | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| CalX-like | 0 | DIRECT |
| Translation proteins SH3-like domain | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| Leucine zipper domain | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| Regulator of G-protein signaling, RGS | 0 | DIRECT |
| SNARE-like | 0 | DIRECT |
| Tropomyosin | 0 | DIRECT |
| Cyclin-like | 0 | DIRECT |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | DIRECT |
| Orange domain-like | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| L27 domain | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Ras GEF | 0 | DIRECT |
| CCCH zinc finger | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| FAD-linked reductases, C-terminal domain | 0 | DIRECT |
| Nucleotide cyclase | 0 | DIRECT |
| F-box domain | 0 | DIRECT |
| Bet v1-like | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| Ricin B-like lectins | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0 | DIRECT |
| Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
| RCC1/BLIP-II | 0 | DIRECT |
| BRCT domain | 0 | DIRECT |
| Cullin repeat-like | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
| Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
| DPP6 N-terminal domain-like | 0 | DIRECT |
| Translation proteins | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| POZ domain | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| alpha/beta-Hydrolases | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| Calcium ATPase, transmembrane domain M | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| SH2 domain | 0 | DIRECT |
| GTPase activation domain, GAP | 0 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0 | DIRECT |
| Calcium ATPase, transduction domain A | 0 | DIRECT |
| Class II aaRS and biotin synthetases | 0 | DIRECT |
| Myosin rod fragments | 0 | DIRECT |
| Galactose-binding domain-like | 0 | DIRECT |
| CAD & PB1 domains | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| TSP-1 type 1 repeat | 0 | DIRECT |
| Metallo-dependent hydrolases | 0 | DIRECT |
| SNARE fusion complex | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Rhodanese/Cell cycle control phosphatase | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| STAT | 0 | DIRECT |
| Phoshotransferase/anion transport protein | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| Cupredoxins | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Riboflavin synthase domain-like | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
| LCCL domain | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| Immunoglobulin | 0.01535 | INHERITED FROM: synencephalon || olfactory bulb glomerulus || medial longitudinal fasciculus || white matter || glomerular layer |
| Homeodomain-like | 0.0402 | INHERITED FROM: endocrine pancreas || forebrain || cephalic musculature || endocrine cell || dorsal telencephalon || pancreatic A cell || diencephalon || preoptic area |
| WD40 repeat-like | 0.05284 | INHERITED FROM: retinal photoreceptor layer || sensory system || eye || photoreceptor outer segment layer || retinal outer nuclear layer |
| Cystine-knot cytokines | 0.07164 | INHERITED FROM: pineal complex || floor plate || cranial blood vessel || spermatogenic cyst |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.1033 | INHERITED FROM: cardiac ventricle || Kolmer-Agduhr neuron || ovarian follicle stage IV || VeLD |
| Growth factor receptor domain | 0.1081 | INHERITED FROM: posterior lateral line ganglion || lymphatic system || blood plasma || blood vasculature || intramembranous bone |
| Nuclear receptor ligand-binding domain | 0.1168 | INHERITED FROM: ovarian follicle stage IV || hypophysis || gonad || reproductive system |
| EGF/Laminin | 0.1882 | INHERITED FROM: posterior lateral line ganglion || vasculature || lymphatic system || pars superior ear || lymph vessel || blood vasculature || lateral line ganglion |
| C-type lectin-like | 0.2822 | INHERITED FROM: lymph vasculature || axial vasculature || lymphatic system || lymph vessel |
| FnI-like domain | 0.2822 | INHERITED FROM: palatoquadrate cartilage || skeletal element || replacement bone || skeletal system || palatoquadrate arch || chondral bone |
| Fibronectin type III | 0.3114 | INHERITED FROM: synencephalon || medial longitudinal fasciculus || white matter || glomerular layer |
| DEATH domain | 0.3846 | INHERITED FROM: blood vasculature |
| Bromodomain | 0.4144 | INHERITED FROM: blood || hematopoietic system |
| Ankyrin repeat | 0.4777 | INHERITED FROM: ventricular zone |
| Snake toxin-like | 0.4841 | INHERITED FROM: axial vasculature |
| lambda repressor-like DNA-binding domains | 0.4841 | INHERITED FROM: diencephalon || digestive system duct |
| Protein kinase-like (PK-like) | 0.5064 | INHERITED FROM: intersegmental vein |
| Cytokine | 0.5221 | INHERITED FROM: chondrocranium || olfactory region || dermatocranium || skeletal element || intramembranous bone |
| Tudor/PWWP/MBT | 0.5221 | INHERITED FROM: primordial germ cell || reproductive system |
| beta-beta-alpha zinc fingers | 0.5239 | INHERITED FROM: ventral thalamus |
| p53-like transcription factors | 0.5429 | INHERITED FROM: Rohon-Beard neuron || primordial vasculature |
| Cadherin-like | 0.5532 | INHERITED FROM: cranial nerve || optic tectum || cranial nerve II || nerve || diencephalic white matter || white matter |
| HLH, helix-loop-helix DNA-binding domain | 0.5652 | INHERITED FROM: Kolmer-Agduhr neuron || heart primordium |
| Protease propeptides/inhibitors | 0.6095 | INHERITED FROM: optic tectum |
| GroEL-intermediate domain like | 0.6095 | INHERITED FROM: trunk musculature || muscle cell || striated muscle cell || myotome || skeletal muscle cell || musculature system || skeletal muscle |
| Multidrug efflux transporter AcrB transmembrane domain | 0.6095 | INHERITED FROM: striated muscle cell || retinal ganglion cell layer || suspensorium || skeletal muscle cell || hyosymplectic cartilage || dorsal hyoid arch || skeletal muscle |
| PDZ domain-like | 0.692 | INHERITED FROM: central canal |
| BAR/IMD domain-like | 0.7008 | INHERITED FROM: olfactory system |
| Retrovirus zinc finger-like domains | 0.7061 | INHERITED FROM: gill || pharynx || respiratory system || pharyngeal arch 3-7 |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7061 | INHERITED FROM: dorsal aorta || artery || axial blood vessel || ventral wall of dorsal aorta |
| ACT-like | 0.7061 | INHERITED FROM: dorsal aorta || artery || axial blood vessel || ventral wall of dorsal aorta |
| HMG-box | 0.7306 | INHERITED FROM: dorsal root ganglion || vagal ganglion || statoacoustic (VIII) ganglion || ganglion || ceratobranchial 5 bone |
| DBL homology domain (DH-domain) | 0.7315 | INHERITED FROM: blood vessel endothelium || blood vessel endothelial cell || vascular endothelium |
| Serine protease inhibitors | 0.763 | INHERITED FROM: otolith || inner ear || otolith organ || vestibuloauditory system |
| Kazal-type serine protease inhibitors | 0.763 | INHERITED FROM: pharynx |
| IP3 receptor type 1 binding core, domain 2 | 0.763 | INHERITED FROM: muscle cell || striated muscle cell || skeletal muscle cell || skeletal muscle |
| WW domain | 0.7637 | INHERITED FROM: striated muscle cell |
| NAD(P)-binding Rossmann-fold domains | 0.8017 | INHERITED FROM: retinal inner plexiform layer || retinal outer plexiform layer |
| GroEL equatorial domain-like | 0.828 | INHERITED FROM: trunk musculature || muscle cell || striated muscle cell || myotome || skeletal muscle cell || skeletal muscle |
| GroEL apical domain-like | 0.8619 | INHERITED FROM: trunk musculature || muscle cell || striated muscle cell || myotome || skeletal muscle cell || skeletal muscle |
| Cysteine proteinases | 0.8817 | INHERITED FROM: mandibular arch skeleton || chondrocranium || olfactory region || skeletal element || pharyngeal arch cartilage || ethmoid cartilage || skeletal system || ventral mandibular arch || neurocranium || cartilage element || splanchnocranium || chondrocranium cartilage |
| MIR domain | 1 | INHERITED FROM: skeletal muscle cell |
| Cytochrome P450 | 1 | INHERITED FROM: hypophysis |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| HSP20-like chaperones | 0 | Direct |
| LDL receptor-like module | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Nucleotidylyl transferase | 0 | Direct |
| Hemopexin-like domain | 0 | Direct |
| CoA-dependent acyltransferases | 0 | Direct |
| UBA-like | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| Nicotinic receptor ligand binding domain-like | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| Ypt/Rab-GAP domain of gyp1p | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| SMAD/FHA domain | 0 | Direct |
| PLP-dependent transferases | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| Translational machinery components | 0 | Direct |
| ENTH/VHS domain | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| Alkaline phosphatase-like | 0 | Direct |
| FAS1 domain | 0 | Direct |
| HIT-like | 0 | Direct |
| Zinc beta-ribbon | 0 | Direct |
| Caspase-like | 0 | Direct |
| Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
| BPTI-like | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| Kringle-like | 0 | Direct |
| Soluble quinoprotein glucose dehydrogenase | 0 | Direct |
| Plexin repeat | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| SET domain | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| Formin homology 2 domain (FH2 domain) | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| CalX-like | 0 | Direct |
| Translation proteins SH3-like domain | 0 | Direct |
| CCHHC domain | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| Leucine zipper domain | 0 | Direct |
| PP2C-like | 0 | Direct |
| Regulator of G-protein signaling, RGS | 0 | Direct |
| SNARE-like | 0 | Direct |
| Tropomyosin | 0 | Direct |
| Cyclin-like | 0 | Direct |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | Direct |
| Orange domain-like | 0 | Direct |
| Integrin domains | 0 | Direct |
| ADC-like | 0 | Direct |
| L27 domain | 0 | Direct |
| Sema domain | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Ras GEF | 0 | Direct |
| CCCH zinc finger | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| FAD-linked reductases, C-terminal domain | 0 | Direct |
| Nucleotide cyclase | 0 | Direct |
| F-box domain | 0 | Direct |
| Bet v1-like | 0 | Direct |
| Tricorn protease domain 2 | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| Ricin B-like lectins | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Ribosomal protein S5 domain 2-like | 0 | Direct |
| Composite domain of metallo-dependent hydrolases | 0 | Direct |
| RCC1/BLIP-II | 0 | Direct |
| BRCT domain | 0 | Direct |
| Cullin repeat-like | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| GLA-domain | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| PGBD-like | 0 | Direct |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
| Glutathione synthetase ATP-binding domain-like | 0 | Direct |
| DPP6 N-terminal domain-like | 0 | Direct |
| Translation proteins | 0 | Direct |
| Notch domain | 0 | Direct |
| Polo-box domain | 0 | Direct |
| POZ domain | 0 | Direct |
| SAICAR synthase-like | 0 | Direct |
| alpha/beta-Hydrolases | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| ALDH-like | 0 | Direct |
| NTF2-like | 0 | Direct |
| Calcium ATPase, transmembrane domain M | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| SH2 domain | 0 | Direct |
| GTPase activation domain, GAP | 0 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0 | Direct |
| Calcium ATPase, transduction domain A | 0 | Direct |
| Class II aaRS and biotin synthetases | 0 | Direct |
| Myosin rod fragments | 0 | Direct |
| Galactose-binding domain-like | 0 | Direct |
| CAD & PB1 domains | 0 | Direct |
| Plakin repeat | 0 | Direct |
| SRF-like | 0 | Direct |
| Aldolase | 0 | Direct |
| Tubulin nucleotide-binding domain-like | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| TSP-1 type 1 repeat | 0 | Direct |
| Metallo-dependent hydrolases | 0 | Direct |
| SNARE fusion complex | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Rhodanese/Cell cycle control phosphatase | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| STAT | 0 | Direct |
| Phoshotransferase/anion transport protein | 0 | Direct |
| Sec7 domain | 0 | Direct |
| Cupredoxins | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Riboflavin synthase domain-like | 0 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
| LCCL domain | 0 | Direct |
| Connexin43 | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| Immunoglobulin | 0.01535 | Inherited |
| Homeodomain-like | 0.0402 | Inherited |
| WD40 repeat-like | 0.05284 | Inherited |
| Cystine-knot cytokines | 0.07164 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.1033 | Inherited |
| Growth factor receptor domain | 0.1081 | Inherited |
| Nuclear receptor ligand-binding domain | 0.1168 | Inherited |
| EGF/Laminin | 0.1882 | Inherited |
| C-type lectin-like | 0.2822 | Inherited |
| FnI-like domain | 0.2822 | Inherited |
| Fibronectin type III | 0.3114 | Inherited |
| DEATH domain | 0.3846 | Inherited |
| Bromodomain | 0.4144 | Inherited |
| Ankyrin repeat | 0.4777 | Inherited |
| Snake toxin-like | 0.4841 | Inherited |
| lambda repressor-like DNA-binding domains | 0.4841 | Inherited |
| Protein kinase-like (PK-like) | 0.5064 | Inherited |
| Cytokine | 0.5221 | Inherited |
| Tudor/PWWP/MBT | 0.5221 | Inherited |
| beta-beta-alpha zinc fingers | 0.5239 | Inherited |
| p53-like transcription factors | 0.5429 | Inherited |
| Cadherin-like | 0.5532 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.5652 | Inherited |
| Protease propeptides/inhibitors | 0.6095 | Inherited |
| GroEL-intermediate domain like | 0.6095 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.6095 | Inherited |
| PDZ domain-like | 0.692 | Inherited |
| BAR/IMD domain-like | 0.7008 | Inherited |
| Retrovirus zinc finger-like domains | 0.7061 | Inherited |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7061 | Inherited |
| ACT-like | 0.7061 | Inherited |
| HMG-box | 0.7306 | Inherited |
| DBL homology domain (DH-domain) | 0.7315 | Inherited |
| Serine protease inhibitors | 0.763 | Inherited |
| Kazal-type serine protease inhibitors | 0.763 | Inherited |
| IP3 receptor type 1 binding core, domain 2 | 0.763 | Inherited |
| WW domain | 0.7637 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 0.8017 | Inherited |
| GroEL equatorial domain-like | 0.828 | Inherited |
| GroEL apical domain-like | 0.8619 | Inherited |
| Cysteine proteinases | 0.8817 | Inherited |
| MIR domain | 1 | Inherited |
| Cytochrome P450 | 1 | Inherited |
(show details)
Supra-domains annotated to this ZA term (Not in SPZA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | DIRECT |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0 | DIRECT |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | DIRECT |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0 | DIRECT |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0 | DIRECT |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0 | DIRECT |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | DIRECT |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | DIRECT |
101288,50156
101288 - L27 domain
50156 - PDZ domain-like | 0 | DIRECT |
52058,49265
52058 - L domain-like
49265 - Fibronectin type III | 0 | DIRECT |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | DIRECT |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
89837,89837
89837 - Doublecortin (DC)
89837 - Doublecortin (DC) | 0 | DIRECT |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0 | DIRECT |
81324,81324
81324 - Voltage-gated potassium channels
81324 - Voltage-gated potassium channels | 0 | DIRECT |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0 | DIRECT |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0 | DIRECT |
49785,57184
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
46966,47473
46966 - Spectrin repeat
47473 - EF-hand | 0 | DIRECT |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0 | DIRECT |
103575,81296
103575 - Plexin repeat
81296 - E set domains | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
49562,48350
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48350 - GTPase activation domain, GAP | 0 | DIRECT |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | DIRECT |
111418,81321
111418 - Hormone receptor domain
81321 - Family A G protein-coupled receptor-like | 0 | DIRECT |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | DIRECT |
49854,49785
49854 - Spermadhesin, CUB domain
49785 - Galactose-binding domain-like | 0 | DIRECT |
82199,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers | 0 | DIRECT |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | DIRECT |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
57196,49854
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0 | DIRECT |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0 | DIRECT |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | DIRECT |
141072,141072
141072 - CalX-like
141072 - CalX-like | 0 | DIRECT |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
49785,49899
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0 | DIRECT |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | DIRECT |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0 | DIRECT |
57184,57603
57184 - Growth factor receptor domain
57603 - FnI-like domain | 0 | DIRECT |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
81296,81296
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | DIRECT |
54001,143791
54001 - Cysteine proteinases
143791 - DUSP-like | 0 | DIRECT |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50978,50998
50978 - WD40 repeat-like
50998 - Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | DIRECT |
49265,49899
49265 - Fibronectin type III
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
100909,49899
100909 - IP3 receptor type 1 binding core, domain 2
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | DIRECT |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
81324,81296
81324 - Voltage-gated potassium channels
81296 - E set domains | 0 | DIRECT |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57603,57603
57603 - FnI-like domain
57603 - FnI-like domain | 0 | DIRECT |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0 | DIRECT |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0 | DIRECT |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | DIRECT |
90257,57997
90257 - Myosin rod fragments
57997 - Tropomyosin | 0 | DIRECT |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0 | DIRECT |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
48097,56112
48097 - Regulator of G-protein signaling, RGS
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
82109,82109
82109 - MIR domain
82109 - MIR domain | 0 | DIRECT |
49854,57196
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin | 0 | DIRECT |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | DIRECT |
82153,82153
82153 - FAS1 domain
82153 - FAS1 domain | 0 | DIRECT |
57850,57850
57850 - RING/U-box
57850 - RING/U-box | 0 | DIRECT |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | DIRECT |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0 | DIRECT |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0 | DIRECT |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | DIRECT |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.01961 | INHERITED FROM: synencephalon || medial longitudinal fasciculus || white matter |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.0511 | INHERITED FROM: posterior lateral line ganglion || vasculature || lymphatic system || lymph vessel || blood vasculature || lateral line ganglion |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.1168 | INHERITED FROM: cardiac ventricle || Kolmer-Agduhr neuron || heart || VeLD |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.1973 | INHERITED FROM: synencephalon || brain nucleus || brainstem || medial longitudinal fasciculus || white matter |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.4011 | INHERITED FROM: head kidney |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.6095 | INHERITED FROM: trunk musculature || muscle cell || striated muscle cell || myotome || skeletal muscle cell || musculature system || skeletal muscle |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.6095 | INHERITED FROM: trunk musculature || muscle cell || striated muscle cell || myotome || skeletal muscle cell || musculature system || skeletal muscle |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.6107 | INHERITED FROM: retinal ganglion cell layer || cranial nerve || optic tectum || cranial nerve II || nerve || diencephalic white matter || white matter |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.642 | INHERITED FROM: ventral thalamus || thalamus |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0.656 | INHERITED FROM: trunk musculature || myotome |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.6692 | INHERITED FROM: pronephros || renal system |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7061 | INHERITED FROM: dorsal aorta || artery || axial blood vessel || ventral wall of dorsal aorta |
82109,100909
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0.763 | INHERITED FROM: muscle cell || striated muscle cell || skeletal muscle cell || skeletal muscle |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.7637 | INHERITED FROM: blood vessel endothelium || blood vessel endothelial cell || vascular endothelium |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 0.828 | INHERITED FROM: eye photoreceptor cell || retinal outer nuclear layer |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | Direct |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0 | Direct |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | Direct |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0 | Direct |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0 | Direct |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0 | Direct |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | Direct |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | Direct |
101288,50156
101288 - L27 domain
50156 - PDZ domain-like | 0 | Direct |
52058,49265
52058 - L domain-like
49265 - Fibronectin type III | 0 | Direct |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | Direct |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
89837,89837
89837 - Doublecortin (DC)
89837 - Doublecortin (DC) | 0 | Direct |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0 | Direct |
81324,81324
81324 - Voltage-gated potassium channels
81324 - Voltage-gated potassium channels | 0 | Direct |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0 | Direct |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0 | Direct |
49785,57184
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | Direct |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0 | Direct |
46966,47473
46966 - Spectrin repeat
47473 - EF-hand | 0 | Direct |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | Direct |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0 | Direct |
103575,81296
103575 - Plexin repeat
81296 - E set domains | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
49562,48350
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48350 - GTPase activation domain, GAP | 0 | Direct |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | Direct |
111418,81321
111418 - Hormone receptor domain
81321 - Family A G protein-coupled receptor-like | 0 | Direct |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | Direct |
49854,49785
49854 - Spermadhesin, CUB domain
49785 - Galactose-binding domain-like | 0 | Direct |
82199,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers | 0 | Direct |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | Direct |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
57196,49854
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | Direct |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0 | Direct |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0 | Direct |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | Direct |
141072,141072
141072 - CalX-like
141072 - CalX-like | 0 | Direct |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
49785,49899
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0 | Direct |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | Direct |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0 | Direct |
57184,57603
57184 - Growth factor receptor domain
57603 - FnI-like domain | 0 | Direct |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
81296,81296
81296 - E set domains
81296 - E set domains | 0 | Direct |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | Direct |
54001,143791
54001 - Cysteine proteinases
143791 - DUSP-like | 0 | Direct |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50978,50998
50978 - WD40 repeat-like
50998 - Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | Direct |
49265,49899
49265 - Fibronectin type III
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
100909,49899
100909 - IP3 receptor type 1 binding core, domain 2
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | Direct |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
81324,81296
81324 - Voltage-gated potassium channels
81296 - E set domains | 0 | Direct |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57603,57603
57603 - FnI-like domain
57603 - FnI-like domain | 0 | Direct |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0 | Direct |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | Direct |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0 | Direct |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | Direct |
90257,57997
90257 - Myosin rod fragments
57997 - Tropomyosin | 0 | Direct |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0 | Direct |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
48097,56112
48097 - Regulator of G-protein signaling, RGS
56112 - Protein kinase-like (PK-like) | 0 | Direct |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
82109,82109
82109 - MIR domain
82109 - MIR domain | 0 | Direct |
49854,57196
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin | 0 | Direct |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | Direct |
82153,82153
82153 - FAS1 domain
82153 - FAS1 domain | 0 | Direct |
57850,57850
57850 - RING/U-box
57850 - RING/U-box | 0 | Direct |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | Direct |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | Direct |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | Direct |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0 | Direct |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0 | Direct |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0 | Direct |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | Direct |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.01961 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.0511 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.1168 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.1973 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.4011 | Inherited |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.6095 | Inherited |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.6095 | Inherited |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.6107 | Inherited |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.642 | Inherited |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0.656 | Inherited |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.6692 | Inherited |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7061 | Inherited |
82109,100909
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0.763 | Inherited |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.7637 | Inherited |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 0.828 | Inherited |
(show details)
Supra-domains annotated to this ZA term (Not in SPZA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
57196,63825,57196
57196 - EGF/Laminin
63825 - YWTD domain
57196 - EGF/Laminin | 0 | DIRECT |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0 | DIRECT |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | DIRECT |
49854,49785,49785
49854 - Spermadhesin, CUB domain
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
90257,90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0 | DIRECT |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
82109,100909,49899
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0 | DIRECT |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
49854,57196,49854
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
49785,49785,49899
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
90193,90193,90193
90193 - Notch domain
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
52743,49785,57184
52743 - Subtilisin-like
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0 | DIRECT |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | DIRECT |
49899,57196,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0 | DIRECT |
82109,82109,100909
82109 - MIR domain
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
75399,75399,75399
75399 - Plakin repeat
75399 - Plakin repeat
75399 - Plakin repeat | 0 | DIRECT |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0 | DIRECT |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
57184,52058,49265
57184 - Growth factor receptor domain
52058 - L domain-like
49265 - Fibronectin type III | 0 | DIRECT |
82199,57667,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0 | DIRECT |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
103575,81296,81296
103575 - Plexin repeat
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
46966,46966,47473
46966 - Spectrin repeat
46966 - Spectrin repeat
47473 - EF-hand | 0 | DIRECT |
57196,90193,90193
57196 - EGF/Laminin
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
52058,49265,49265
52058 - L domain-like
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.04331 | INHERITED FROM: synencephalon || medial longitudinal fasciculus || white matter |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.2734 | INHERITED FROM: synencephalon || brain nucleus || brainstem || skeletal muscle cell || medial longitudinal fasciculus || white matter |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.3564 | INHERITED FROM: cardiac ventricle |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.6095 | INHERITED FROM: trunk musculature || muscle cell || striated muscle cell || myotome || skeletal muscle cell || musculature system || skeletal muscle |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.6398 | INHERITED FROM: retinal ganglion cell layer || cranial nerve || optic tectum || cranial nerve II || macula || nerve || diencephalic white matter || white matter |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
57196,63825,57196
57196 - EGF/Laminin
63825 - YWTD domain
57196 - EGF/Laminin | 0 | Direct |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0 | Direct |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | Direct |
49854,49785,49785
49854 - Spermadhesin, CUB domain
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
90257,90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0 | Direct |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
82109,100909,49899
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0 | Direct |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
49854,57196,49854
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | Direct |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
49785,49785,49899
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
90193,90193,90193
90193 - Notch domain
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
52743,49785,57184
52743 - Subtilisin-like
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | Direct |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0 | Direct |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | Direct |
49899,57196,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0 | Direct |
82109,82109,100909
82109 - MIR domain
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
75399,75399,75399
75399 - Plakin repeat
75399 - Plakin repeat
75399 - Plakin repeat | 0 | Direct |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | Direct |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0 | Direct |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
57184,52058,49265
57184 - Growth factor receptor domain
52058 - L domain-like
49265 - Fibronectin type III | 0 | Direct |
82199,57667,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0 | Direct |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
103575,81296,81296
103575 - Plexin repeat
81296 - E set domains
81296 - E set domains | 0 | Direct |
46966,46966,47473
46966 - Spectrin repeat
46966 - Spectrin repeat
47473 - EF-hand | 0 | Direct |
57196,90193,90193
57196 - EGF/Laminin
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
52058,49265,49265
52058 - L domain-like
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.04331 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.2734 | Inherited |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.3564 | Inherited |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.6095 | Inherited |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.6398 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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