Zebrafish Anatomy (ZA): anatomical cluster

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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology (DO)
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology (HP)
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology (MP)
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology (WP)
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology (YP)
Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology (FP)
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology (FA)
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology (ZA)
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology (XA)
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology (AP)
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
DrugBank ATC (DB) Ontology (DB)
In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
UniProtKB KeyWords (KW) Ontology (KW)
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
UniProtKB UniPathway (UP) Ontology (UP)
UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: ZA Hierarchy (zebrafish anatomy from ZFIN zebrafish anatomy ontology)

Shortest distance to current term (+ for parents, - for children) ZA term [ZA ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)

+ + + 3: zebrafish anatomical entity [ZFA:0100000] <6>

+ + 2: anatomical structure [ZFA:0000037] <16> (275|296) (275|157|73)

+ 1: anatomical group [ZFA:0001512] <5> (178|208) (181|127|60)

0: anatomical cluster [ZFA:0001478] <54> (36|54) (40|27|20)

- 1: joint [ZFA:0001596] <35> (0|0) (0|0|0)

- 1: neurocranium [ZFA:0001580] <31> (1|2) (2|0|0)

- 1: dermatocranium [ZFA:0000863] <24> (1|1) (1|0|0)

- 1: chondrocranium [ZFA:0001424] <15> (1|2) (3|0|0)

- 1: pharyngeal arch 3-7 skeleton [ZFA:0000095] <15> (0|1) (1|0|0)

- 1: neuromast [ZFA:0000243] <14> (0|0) (0|0|0)

- 1: pleuroperitoneal region [ZFA:0007116] <11> (6|9) (8|2|0)

- 1: dorsal fin pterygiophore [ZFA:0001419] <10> (0|0) (0|0|0)

- 1: olfactory region [ZFA:0000351] <10> (2|3) (3|0|0)

- 1: inner ear [ZFA:0000217] <9> (3|4) (3|0|2)

- 1: oral region [ZFA:0000590] <9> (2|2) (2|0|1)

- 1: pectoral girdle [ZFA:0000407] <9> (0|0) (0|0|0)

- 1: ventral hyoid arch [ZFA:0001402] <9> (1|1) (1|0|0)

- 1: otic region [ZFA:0000189] <8> (0|0) (0|0|0)

- 1: palatoquadrate arch [ZFA:0001272] <8> (1|0) (1|0|1)

- 1: pharyngeal arch 4 skeleton [ZFA:0001231] <8> (0|0) (0|0|0)

- 1: pharyngeal arch 5 skeleton [ZFA:0001232] <8> (0|0) (0|0|0)

- 1: cranial vault [ZFA:0005606] <7> (0|0) (0|0|0)

- 1: dorsal hyoid arch [ZFA:0001401] <7> (1|1) (1|0|0)

- 1: pharyngeal arch 6 skeleton [ZFA:0001230] <7> (0|0) (0|0|0)

- 1: anterior segment eye [ZFA:0005566] <6> (0|1) (0|0|0)

- 1: orbital region [ZFA:0001410] <6> (0|0) (0|0|0)

- 1: pharyngeal arch 3 skeleton [ZFA:0001228] <6> (0|0) (0|0|0)

- 1: ventral mandibular arch [ZFA:0001273] <6> (1|2) (1|0|0)

- 1: infraorbital series [ZFA:0001649] <5> (0|0) (0|0|0)

- 1: pericardial region [ZFA:0007115] <5> (6|8) (6|3|4)

- 1: sphenoid region [ZFA:0000290] <5> (0|0) (0|0|0)

- 1: splanchnocranium [ZFA:0001216] <5> (4|4) (5|1|1)

- 1: Weberian apparatus [ZFA:0001188] <4> (0|0) (0|0|0)

- 1: nephron [ZFA:0005282] <4> (0|1) (0|0|0)

- 1: occipital region [ZFA:0001414] <4> (0|0) (0|0|0)

- 1: palate [ZFA:0005509] <4> (0|0) (0|0|0)

- 1: pars superior ear [ZFA:0005409] <4> (1|3) (1|0|1)

- 1: proliferative region [ZFA:0000098] <4> (0|0) (1|0|0)

- 1: medial column [ZFA:0000542] <3> (0|0) (0|0|0)

- 1: pancreatic lobule [ZFA:0005753] <3> (0|0) (0|0|0)

- 1: pars inferior ear [ZFA:0005410] <3> (0|0) (0|0|0)

- 1: pharyngeal arch 7 skeleton [ZFA:0001229] <3> (0|1) (1|0|0)

- 1: posterior segment eye [ZFA:0005567] <3> (5|6) (5|4|3)

- 1: tooth row [ZFA:0001642] <3> (0|0) (0|0|0)

- 1: vertebral column [ZFA:0001559] <3> (0|1) (0|0|0)

- 1: anal fin pterygiophore [ZFA:0001420] <2> (0|0) (0|0|0)

- 1: lagenar capsule [ZFA:0001627] <2> (0|0) (0|0|0)

- 1: mandibular arch skeleton [ZFA:0001227] <2> (2|2) (2|1|1)

- 1: neural complex [ZFA:0001363] <2> (0|0) (0|0|0)

- 1: pharyngeal arch 2 skeleton [ZFA:0001276] <2> (2|1) (2|0|0)

- 1: suspensorium [ZFA:0000444] <2> (2|1) (2|0|1)

- 1: lateral column [ZFA:0000531] <1> (0|0) (0|0|0)

- 1: midline column [ZFA:0000241] <1> (0|0) (0|0|0)

- 1: pelvic girdle [ZFA:0000565] <1> (0|0) (0|0|0)

- 1: bony shelf above orbit [ZFA:0005531] (0|0) (0|0|0)

- 1: intervening zone [ZFA:0001341] (0|0) (0|0|0)

- 1: protoneuromast [ZFA:0005227] (0|0) (0|0|0)

- 1: visceromotor column [ZFA:0000611] (0|0) (0|0|0)

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Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Aquaporin-like	0	Direct
Moesin tail domain	0	Direct
ADC-like	0	Direct
Cap-Gly domain	0	Direct
Caspase-like	0	Direct
Phoshotransferase/anion transport protein	0	Direct
Kazal-type serine protease inhibitors	0	Direct
Cdc48 domain 2-like	0	Direct
Plakin repeat	0	Direct
Translational machinery components	0	Direct
SRF-like	0	Direct
Hemopexin-like domain	0	Direct
PGBD-like	0	Direct
Glutathione synthetase ATP-binding domain-like	0	Direct
CalX-like	0	Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	Direct
Composite domain of metallo-dependent hydrolases	0	Direct
Class I glutamine amidotransferase-like	0	Direct
Ras GEF	0	Direct
Notch domain	0	Direct
Glucocorticoid receptor-like (DNA-binding domain)	0.02744	Inherited
WD40 repeat-like	0.1054	Inherited
FnI-like domain	0.1352	Inherited
Nuclear receptor ligand-binding domain	0.1488	Inherited
Cysteine proteinases	0.2541	Inherited
Alkaline phosphatase-like	0.2552	Inherited
Serine protease inhibitors	0.2614	Inherited
NAD(P)-binding Rossmann-fold domains	0.2963	Inherited
Cytokine	0.3834	Inherited
Mitochondrial carrier	0.406	Inherited
Tropomyosin	0.5165	Inherited
Cystine-knot cytokines	0.5422	Inherited
Multidrug efflux transporter AcrB transmembrane domain	0.5742	Inherited
Homeodomain-like	0.6263	Inherited
Carbonic anhydrase	0.692	Inherited
EGF/Laminin	0.695	Inherited

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
SRF-like	0	Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	Direct
Cdc48 domain 2-like	0	Direct
Hydantoinase (dihydropyrimidinase)	0	Direct
Aquaporin-like	0	Direct
Nitrogenase iron protein-like	0	Direct
Class I glutamine amidotransferases (GAT)	0	Direct
CalX-beta domain	0	Direct
P4 origin-binding domain-like	0	Direct
Cytoplasmic domain of inward rectifier potassium channel	0	Direct
Anion transport protein, cytoplasmic domain	0	Direct
V set domains (antibody variable domain-like)	0	Direct
Cap-Gly domain	0	Direct
C5 cytosine-specific DNA methylase, DCM	0	Direct
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta	0	Direct
Connexin43	0	Direct
Proprotein convertase P-domain	0	Direct
Hydantoinase (dihydropyrimidinase), catalytic domain	0	Direct
Moesin tail domain	0	Direct
Erythroid transcription factor GATA-1	0	Direct
Plakin repeat	0	Direct
Long-chain cytokines	0	Direct
Prohormone convertase 1 pro-domain	0	Direct
Caspase catalytic domain	0	Direct
Ubiquitin-related	0	Direct
BCR-homology GTPase activation domain (BH-domain)	0	Direct
Notch domain	0	Direct
Ras GEF	0	Direct
Cdc48 N-terminal domain-like	0	Direct
MMP N-terminal domain	0	Direct
Ovomucoid domain III-like	0	Direct
Single strand DNA-binding domain, SSB	0	Direct
Hemopexin-like domain	0	Direct
Growth factor receptor domain	0.01423	Inherited
T-box	0.03557	Inherited
Paired domain	0.06018	Inherited
Nuclear receptor ligand-binding domain	0.1156	Inherited
Motor proteins	0.1286	Inherited
Ubiquitin carboxyl-terminal hydrolase, UCH	0.1346	Inherited
Tetratricopeptide repeat (TPR)	0.1346	Inherited
Nuclear receptor	0.1395	Inherited
Multidrug efflux transporter AcrB transmembrane domain	0.1536	Inherited
LIM domain	0.2398	Inherited
WD40-repeat	0.2443	Inherited
Zf-UBP	0.2875	Inherited
Fibroblast growth factors (FGF)	0.3416	Inherited
Calcium ATPase, transmembrane domain M	0.3629	Inherited
EGF-type module	0.3996	Inherited
Homeodomain	0.4229	Inherited
Tropomyosin	0.4728	Inherited
VWC domain	0.4728	Inherited
Transforming growth factor (TGF)-beta	0.4893	Inherited
HMG-box	0.5514	Inherited
Carbonic anhydrase	0.6558	Inherited

Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term

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Supra-domain (including individual superfamily)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Hemopexin-like domain	0	Direct
Moesin tail domain	0	Direct
Translational machinery components	0	Direct
Kazal-type serine protease inhibitors	0	Direct
Caspase-like	0	Direct
Aquaporin-like	0	Direct
CalX-like	0	Direct
ADC-like	0	Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	Direct
Ras GEF	0	Direct
Composite domain of metallo-dependent hydrolases	0	Direct
Cap-Gly domain	0	Direct
PGBD-like	0	Direct
Glutathione synthetase ATP-binding domain-like	0	Direct
Notch domain	0	Direct
Class I glutamine amidotransferase-like	0	Direct
Plakin repeat	0	Direct
SRF-like	0	Direct
Cdc48 domain 2-like	0	Direct
Phoshotransferase/anion transport protein	0	Direct
Glucocorticoid receptor-like (DNA-binding domain)	0.01988	Inherited
WD40 repeat-like	0.08418	Inherited
FnI-like domain	0.1113	Inherited
Nuclear receptor ligand-binding domain	0.1236	Inherited
Cysteine proteinases	0.222	Inherited
Alkaline phosphatase-like	0.2234	Inherited
Serine protease inhibitors	0.2297	Inherited
NAD(P)-binding Rossmann-fold domains	0.2642	Inherited
Cytokine	0.349	Inherited
Mitochondrial carrier	0.3713	Inherited
Quinoprotein alcohol dehydrogenase-like	0.4047	Inherited
Ankyrin repeat	0.4632	Inherited
Tropomyosin	0.4844	Inherited
Cystine-knot cytokines	0.5102	Inherited
Multidrug efflux transporter AcrB transmembrane domain	0.5435	Inherited
HMG-box	0.5662	Inherited
Homeodomain-like	0.5978	Inherited
Carbonic anhydrase	0.6658	Inherited
EGF/Laminin	0.6692	Inherited
UBA-like	0.7821	Inherited

(show details)

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0	Direct
57440,57440 57440 - Kringle-like 57440 - Kringle-like	0	Direct
81324,81324 81324 - Voltage-gated potassium channels 81324 - Voltage-gated potassium channels	0	Direct
49785,57184 49785 - Galactose-binding domain-like 57184 - Growth factor receptor domain	0	Direct
46966,47473 46966 - Spectrin repeat 47473 - EF-hand	0	Direct
47986,52129 47986 - DEATH domain 52129 - Caspase-like	0	Direct
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM	0	Direct
90193,90193 90193 - Notch domain 90193 - Notch domain	0	Direct
141072,141072 141072 - CalX-like 141072 - CalX-like	0	Direct
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin	0	Direct
57184,57603 57184 - Growth factor receptor domain 57603 - FnI-like domain	0	Direct
47090,55486 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain	0	Direct
54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I)	0	Direct
75399,75399 75399 - Plakin repeat 75399 - Plakin repeat	0	Direct
52743,49785 52743 - Subtilisin-like 49785 - Galactose-binding domain-like	0	Direct
81324,81296 81324 - Voltage-gated potassium channels 81296 - E set domains	0	Direct
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
51556,51338 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases	0	Direct
48097,56112 48097 - Regulator of G-protein signaling, RGS 56112 - Protein kinase-like (PK-like)	0	Direct
57196,90193 57196 - EGF/Laminin 90193 - Notch domain	0	Direct
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like	0	Direct
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger	0	Direct
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.05623	Inherited
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like	0.218	Inherited
50156,50156 50156 - PDZ domain-like 50156 - PDZ domain-like	0.2737	Inherited
48452,48452 48452 - TPR-like 48452 - TPR-like	0.3284	Inherited
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III	0.9427	Inherited

(show details)

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57196,57184,57196 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0	Direct
57603,57603,57603 57603 - FnI-like domain 57603 - FnI-like domain 57603 - FnI-like domain	0	Direct
57184,57184,57196 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0	Direct
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
57196,57196,90193 57196 - EGF/Laminin 57196 - EGF/Laminin 90193 - Notch domain	0	Direct
90193,90193,90193 90193 - Notch domain 90193 - Notch domain 90193 - Notch domain	0	Direct
57196,57184,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0	Direct
52743,49785,57184 52743 - Subtilisin-like 49785 - Galactose-binding domain-like 57184 - Growth factor receptor domain	0	Direct
57184,57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0	Direct
54897,52743,49785 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like 49785 - Galactose-binding domain-like	0	Direct
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
75399,75399,75399 75399 - Plakin repeat 75399 - Plakin repeat 75399 - Plakin repeat	0	Direct
48726,49265,48726 48726 - Immunoglobulin 49265 - Fibronectin type III 48726 - Immunoglobulin	0	Direct
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like	0	Direct
47090,55486,50923 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0	Direct
46966,46966,47473 46966 - Spectrin repeat 46966 - Spectrin repeat 47473 - EF-hand	0	Direct
57196,90193,90193 57196 - EGF/Laminin 90193 - Notch domain 90193 - Notch domain	0	Direct
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like	0.1306	Inherited
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.2227	Inherited
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.494	Inherited

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Zebrafish Anatomy (ZA): anatomical cluster

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Supra-domain (including individual superfamily)