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Zebrafish Anatomy (ZA): multi-tissue structure
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: ZA Hierarchy (zebrafish anatomy from ZFIN zebrafish anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this ZA term (SDZA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
PWWP domain | 0 | DIRECT |
Platelet-derived growth factor-like | 0 | DIRECT |
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | DIRECT |
Cdc48 domain 2-like | 0 | DIRECT |
Hydantoinase (dihydropyrimidinase) | 0 | DIRECT |
Sec7 domain | 0 | DIRECT |
SNARE fusion complex | 0 | DIRECT |
Nitrogenase iron protein-like | 0 | DIRECT |
Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
CalX-beta domain | 0 | DIRECT |
LDL receptor-like module | 0 | DIRECT |
Cytoplasmic domain of inward rectifier potassium channel | 0 | DIRECT |
V set domains (antibody variable domain-like) | 0 | DIRECT |
Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
Cap-Gly domain | 0 | DIRECT |
C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
Histone deacetylase, HDAC | 0 | DIRECT |
Noncollagenous (NC1) domain of collagen IV | 0 | DIRECT |
Pyridoxal-dependent decarboxylase | 0 | DIRECT |
CCHHC domain | 0 | DIRECT |
Link domain | 0 | DIRECT |
LCCL domain | 0 | DIRECT |
Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
Reprolysin-like | 0 | DIRECT |
Doublecortin (DC) | 0 | DIRECT |
Extracellular domain of cell surface receptors | 0 | DIRECT |
SMAD MH1 domain | 0 | DIRECT |
Hormone receptor domain | 0 | DIRECT |
SMAD domain | 0 | DIRECT |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | DIRECT |
Glycerophosphoryl diester phosphodiesterase | 0 | DIRECT |
Moesin tail domain | 0 | DIRECT |
Erythroid transcription factor GATA-1 | 0 | DIRECT |
Tetramerization domain of potassium channels | 0 | DIRECT |
Long-chain cytokines | 0 | DIRECT |
Myotubularin-like phosphatases | 0 | DIRECT |
Caspase catalytic domain | 0 | DIRECT |
Cell cycle transcription factor e2f-dp | 0 | DIRECT |
PP2C-like | 0 | DIRECT |
Notch domain | 0 | DIRECT |
Ras GEF | 0 | DIRECT |
Cdc48 N-terminal domain-like | 0 | DIRECT |
Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
Ovomucoid domain III-like | 0 | DIRECT |
Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
BRK domain-like | 0 | DIRECT |
Homeodomain | 0.0007628 | DIRECT |
Nuclear receptor ligand-binding domain | 0.01758 | INHERITED FROM: ovarian follicle stage IV || hypophysis |
Nuclear receptor | 0.02303 | INHERITED FROM: ovarian follicle stage IV || hypophysis |
I set domains | 0.02583 | INHERITED FROM: synencephalon || medial longitudinal fasciculus || white matter |
Cytochrome P450 | 0.06641 | INHERITED FROM: hypophysis |
PDZ domain | 0.07545 | INHERITED FROM: central canal |
Zf-UBP | 0.08981 | INHERITED FROM: pericardium || ventral mandibular arch || Meckel's cartilage |
Ubiquitin carboxyl-terminal hydrolase, UCH | 0.1097 | INHERITED FROM: pharyngeal arch 1 || pericardium || serous membrane || ventral mandibular arch || mandibular arch skeleton |
Fibronectin type III | 0.1102 | INHERITED FROM: glomerular layer || synencephalon || medial longitudinal fasciculus || white matter |
POU-specific domain | 0.1226 | INHERITED FROM: diencephalon || forebrain |
Protein kinases, catalytic subunit | 0.1737 | INHERITED FROM: scale || dorsal longitudinal anastomotic vessel || dermal superficial region || dermis |
Phenylalanine metabolism regulatory domain | 0.2296 | INHERITED FROM: artery || axial blood vessel || dorsal aorta || ventral wall of dorsal aorta |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.2296 | INHERITED FROM: artery || axial blood vessel || dorsal aorta || ventral wall of dorsal aorta |
Multidrug efflux transporter AcrB transmembrane domain | 0.2296 | INHERITED FROM: pharyngeal arch 2 skeleton || ventral hyoid arch || hyosymplectic cartilage || retinal ganglion cell layer || pharyngeal arch 2 || dorsal hyoid arch |
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.2296 | INHERITED FROM: artery || brain vasculature || cranial vasculature |
T-box | 0.23 | INHERITED FROM: atrioventricular canal || immature eye |
WD40-repeat | 0.2537 | INHERITED FROM: retinal cone cell || photoreceptor outer segment layer |
Tetratricopeptide repeat (TPR) | 0.4642 | INHERITED FROM: retinal rod cell |
HMG-box | 0.4642 | INHERITED FROM: ceratobranchial 5 bone |
Transforming growth factor (TGF)-beta | 0.4692 | INHERITED FROM: pineal complex || floor plate |
Retrovirus zinc finger-like domains | 0.5762 | INHERITED FROM: pharyngeal arch 3-7 || pharynx |
Motor proteins | 0.6145 | INHERITED FROM: pronephric podocyte || renal corpuscle || photoreceptor outer segment layer |
Cadherin | 0.6942 | INHERITED FROM: optic tectum || diencephalic white matter || white matter || cranial nerve II |
Tropomyosin | 0.7418 | INHERITED FROM: sinus venosus |
VWC domain | 0.7418 | INHERITED FROM: ventral fin fold |
Classic zinc finger, C2H2 | 0.7648 | INHERITED FROM: ventral thalamus || thalamus |
DBL homology domain (DH-domain) | 0.8305 | INHERITED FROM: vascular endothelium || blood vessel endothelium || blood vessel endothelial cell |
SCOP term | FDR (all) | Annotation (direct or inherited) |
PWWP domain | 0 | Direct |
Platelet-derived growth factor-like | 0 | Direct |
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | Direct |
Cdc48 domain 2-like | 0 | Direct |
Hydantoinase (dihydropyrimidinase) | 0 | Direct |
Sec7 domain | 0 | Direct |
SNARE fusion complex | 0 | Direct |
Nitrogenase iron protein-like | 0 | Direct |
Class I glutamine amidotransferases (GAT) | 0 | Direct |
CalX-beta domain | 0 | Direct |
LDL receptor-like module | 0 | Direct |
Cytoplasmic domain of inward rectifier potassium channel | 0 | Direct |
V set domains (antibody variable domain-like) | 0 | Direct |
Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
Cap-Gly domain | 0 | Direct |
C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
Histone deacetylase, HDAC | 0 | Direct |
Noncollagenous (NC1) domain of collagen IV | 0 | Direct |
Pyridoxal-dependent decarboxylase | 0 | Direct |
CCHHC domain | 0 | Direct |
Link domain | 0 | Direct |
LCCL domain | 0 | Direct |
Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
Anticodon-binding domain of Class II aaRS | 0 | Direct |
Reprolysin-like | 0 | Direct |
Doublecortin (DC) | 0 | Direct |
Extracellular domain of cell surface receptors | 0 | Direct |
SMAD MH1 domain | 0 | Direct |
Hormone receptor domain | 0 | Direct |
SMAD domain | 0 | Direct |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
Nuclear receptor coactivator interlocking domain | 0 | Direct |
Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | Direct |
Glycerophosphoryl diester phosphodiesterase | 0 | Direct |
Moesin tail domain | 0 | Direct |
Erythroid transcription factor GATA-1 | 0 | Direct |
Tetramerization domain of potassium channels | 0 | Direct |
Long-chain cytokines | 0 | Direct |
Myotubularin-like phosphatases | 0 | Direct |
Caspase catalytic domain | 0 | Direct |
Cell cycle transcription factor e2f-dp | 0 | Direct |
PP2C-like | 0 | Direct |
Notch domain | 0 | Direct |
Ras GEF | 0 | Direct |
Cdc48 N-terminal domain-like | 0 | Direct |
Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
Ovomucoid domain III-like | 0 | Direct |
Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
BRK domain-like | 0 | Direct |
Homeodomain | 0.0007628 | Direct |
Nuclear receptor ligand-binding domain | 0.01758 | Inherited |
Nuclear receptor | 0.02303 | Inherited |
I set domains | 0.02583 | Inherited |
Cytochrome P450 | 0.06641 | Inherited |
PDZ domain | 0.07545 | Inherited |
Zf-UBP | 0.08981 | Inherited |
Ubiquitin carboxyl-terminal hydrolase, UCH | 0.1097 | Inherited |
Fibronectin type III | 0.1102 | Inherited |
POU-specific domain | 0.1226 | Inherited |
Protein kinases, catalytic subunit | 0.1737 | Inherited |
Phenylalanine metabolism regulatory domain | 0.2296 | Inherited |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.2296 | Inherited |
Multidrug efflux transporter AcrB transmembrane domain | 0.2296 | Inherited |
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.2296 | Inherited |
T-box | 0.23 | Inherited |
WD40-repeat | 0.2537 | Inherited |
Tetratricopeptide repeat (TPR) | 0.4642 | Inherited |
HMG-box | 0.4642 | Inherited |
Transforming growth factor (TGF)-beta | 0.4692 | Inherited |
Retrovirus zinc finger-like domains | 0.5762 | Inherited |
Motor proteins | 0.6145 | Inherited |
Cadherin | 0.6942 | Inherited |
Tropomyosin | 0.7418 | Inherited |
VWC domain | 0.7418 | Inherited |
Classic zinc finger, C2H2 | 0.7648 | Inherited |
DBL homology domain (DH-domain) | 0.8305 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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Supra-domain (including individual superfamily)
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Supra-domains annotated to this ZA term (SPZA level: Least Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module | 0 | DIRECT |
55550,55550 55550 - SH2 domain 55550 - SH2 domain | 0 | DIRECT |
57440,57440 57440 - Kringle-like 57440 - Kringle-like | 0 | DIRECT |
48425,50729 48425 - Sec7 domain 50729 - PH domain-like | 0 | DIRECT |
52058,49265 52058 - L domain-like 49265 - Fibronectin type III | 0 | DIRECT |
56968,48431 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions 48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
89837,89837 89837 - Doublecortin (DC) 89837 - Doublecortin (DC) | 0 | DIRECT |
103575,81296 103575 - Plexin repeat 81296 - E set domains | 0 | DIRECT |
47986,52129 47986 - DEATH domain 52129 - Caspase-like | 0 | DIRECT |
63380,52343 63380 - Riboflavin synthase domain-like 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
111418,81321 111418 - Hormone receptor domain 81321 - Family A G protein-coupled receptor-like | 0 | DIRECT |
90193,90193 90193 - Notch domain 90193 - Notch domain | 0 | DIRECT |
46785,46785 46785 - "Winged helix" DNA-binding domain 46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
57196,63825 57196 - EGF/Laminin 63825 - YWTD domain | 0 | DIRECT |
141072,141072 141072 - CalX-like 141072 - CalX-like | 0 | DIRECT |
57196,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain | 0 | DIRECT |
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
57184,57603 57184 - Growth factor receptor domain 57603 - FnI-like domain | 0 | DIRECT |
49417,81296 49417 - p53-like transcription factors 81296 - E set domains | 0 | DIRECT |
50156,50044 50156 - PDZ domain-like 50044 - SH3-domain | 0 | DIRECT |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0 | DIRECT |
49265,49899 49265 - Fibronectin type III 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
81324,81296 81324 - Voltage-gated potassium channels 81296 - E set domains | 0 | DIRECT |
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51556,51338 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
63825,57196 63825 - YWTD domain 57196 - EGF/Laminin | 0 | DIRECT |
52799,49562 52799 - (Phosphotyrosine protein) phosphatases II 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
48097,56112 48097 - Regulator of G-protein signaling, RGS 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57196,90193 57196 - EGF/Laminin 90193 - Notch domain | 0 | DIRECT |
49854,57196 49854 - Spermadhesin, CUB domain 57196 - EGF/Laminin | 0 | DIRECT |
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like | 0 | DIRECT |
57850,57850 57850 - RING/U-box 57850 - RING/U-box | 0 | DIRECT |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.002359 | INHERITED FROM: white matter || synencephalon || medial longitudinal fasciculus |
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain | 0.00504 | INHERITED FROM: blood vessel endothelium || vasculature |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.03065 | INHERITED FROM: brainstem || white matter || synencephalon || medial longitudinal fasciculus |
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0.06008 | INHERITED FROM: lymph vessel || blood vasculature || blood vessel || vasculature |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.06177 | INHERITED FROM: lymph vessel || blood vasculature || vasculature |
50156,50156 50156 - PDZ domain-like 50156 - PDZ domain-like | 0.1794 | INHERITED FROM: retinal outer nuclear layer || eye photoreceptor cell |
55021,56534 55021 - ACT-like 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.2229 | INHERITED FROM: ventral wall of dorsal aorta || axial blood vessel || artery || dorsal aorta |
49562,48350 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48350 - GTPase activation domain, GAP | 0.3025 | INHERITED FROM: hindbrain |
57603,57603 57603 - FnI-like domain 57603 - FnI-like domain | 0.4627 | INHERITED FROM: axial blood vessel || vein |
54897,52743 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like | 0.4627 | INHERITED FROM: optic tectum |
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like | 0.7414 | INHERITED FROM: diencephalic white matter || white matter || retinal ganglion cell layer || cranial nerve II || optic tectum |
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like | 0.8822 | INHERITED FROM: vascular endothelium || blood vessel endothelial cell || blood vessel endothelium |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.9271 | INHERITED FROM: thalamus || ventral thalamus |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module | 0 | Direct |
55550,55550 55550 - SH2 domain 55550 - SH2 domain | 0 | Direct |
57440,57440 57440 - Kringle-like 57440 - Kringle-like | 0 | Direct |
48425,50729 48425 - Sec7 domain 50729 - PH domain-like | 0 | Direct |
52058,49265 52058 - L domain-like 49265 - Fibronectin type III | 0 | Direct |
56968,48431 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions 48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
89837,89837 89837 - Doublecortin (DC) 89837 - Doublecortin (DC) | 0 | Direct |
103575,81296 103575 - Plexin repeat 81296 - E set domains | 0 | Direct |
47986,52129 47986 - DEATH domain 52129 - Caspase-like | 0 | Direct |
63380,52343 63380 - Riboflavin synthase domain-like 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
111418,81321 111418 - Hormone receptor domain 81321 - Family A G protein-coupled receptor-like | 0 | Direct |
90193,90193 90193 - Notch domain 90193 - Notch domain | 0 | Direct |
46785,46785 46785 - "Winged helix" DNA-binding domain 46785 - "Winged helix" DNA-binding domain | 0 | Direct |
57196,63825 57196 - EGF/Laminin 63825 - YWTD domain | 0 | Direct |
141072,141072 141072 - CalX-like 141072 - CalX-like | 0 | Direct |
57196,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain | 0 | Direct |
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
57184,57603 57184 - Growth factor receptor domain 57603 - FnI-like domain | 0 | Direct |
49417,81296 49417 - p53-like transcription factors 81296 - E set domains | 0 | Direct |
50156,50044 50156 - PDZ domain-like 50044 - SH3-domain | 0 | Direct |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0 | Direct |
49265,49899 49265 - Fibronectin type III 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
81324,81296 81324 - Voltage-gated potassium channels 81296 - E set domains | 0 | Direct |
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51556,51338 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases | 0 | Direct |
63825,57196 63825 - YWTD domain 57196 - EGF/Laminin | 0 | Direct |
52799,49562 52799 - (Phosphotyrosine protein) phosphatases II 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
48097,56112 48097 - Regulator of G-protein signaling, RGS 56112 - Protein kinase-like (PK-like) | 0 | Direct |
57196,90193 57196 - EGF/Laminin 90193 - Notch domain | 0 | Direct |
49854,57196 49854 - Spermadhesin, CUB domain 57196 - EGF/Laminin | 0 | Direct |
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like | 0 | Direct |
57850,57850 57850 - RING/U-box 57850 - RING/U-box | 0 | Direct |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.002359 | Inherited |
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain | 0.00504 | Inherited |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.03065 | Inherited |
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0.06008 | Inherited |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.06177 | Inherited |
50156,50156 50156 - PDZ domain-like 50156 - PDZ domain-like | 0.1794 | Inherited |
55021,56534 55021 - ACT-like 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.2229 | Inherited |
49562,48350 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48350 - GTPase activation domain, GAP | 0.3025 | Inherited |
57603,57603 57603 - FnI-like domain 57603 - FnI-like domain | 0.4627 | Inherited |
54897,52743 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like | 0.4627 | Inherited |
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like | 0.7414 | Inherited |
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like | 0.8822 | Inherited |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.9271 | Inherited |
(show details)
Supra-domains annotated to this ZA term (SPZA level: Least Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,63825,57196 57196 - EGF/Laminin 63825 - YWTD domain 57196 - EGF/Laminin | 0 | DIRECT |
57196,57184,57196 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0 | DIRECT |
57184,57184,57196 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0 | DIRECT |
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
57196,49899,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
49854,57196,49854 49854 - Spermadhesin, CUB domain 57196 - EGF/Laminin 49854 - Spermadhesin, CUB domain | 0 | DIRECT |
57196,57196,90193 57196 - EGF/Laminin 57196 - EGF/Laminin 90193 - Notch domain | 0 | DIRECT |
90193,90193,90193 90193 - Notch domain 90193 - Notch domain 90193 - Notch domain | 0 | DIRECT |
57196,57184,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0 | DIRECT |
50156,50044,52540 50156 - PDZ domain-like 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57850,57850,57850 57850 - RING/U-box 57850 - RING/U-box 57850 - RING/U-box | 0 | DIRECT |
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57424,57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module 57424 - LDL receptor-like module | 0 | DIRECT |
57184,52058,49265 57184 - Growth factor receptor domain 52058 - L domain-like 49265 - Fibronectin type III | 0 | DIRECT |
103575,81296,81296 103575 - Plexin repeat 81296 - E set domains 81296 - E set domains | 0 | DIRECT |
57196,90193,90193 57196 - EGF/Laminin 90193 - Notch domain 90193 - Notch domain | 0 | DIRECT |
52058,49265,49265 52058 - L domain-like 49265 - Fibronectin type III 49265 - Fibronectin type III | 0 | DIRECT |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.002423 | INHERITED FROM: white matter || synencephalon || medial longitudinal fasciculus |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.08707 | INHERITED FROM: brainstem || white matter || synencephalon || medial longitudinal fasciculus |
57603,57603,57603 57603 - FnI-like domain 57603 - FnI-like domain 57603 - FnI-like domain | 0.2229 | INHERITED FROM: axial blood vessel || vein |
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like | 0.631 | INHERITED FROM: diencephalic white matter || white matter || retinal ganglion cell layer || cranial nerve II || optic tectum |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,63825,57196 57196 - EGF/Laminin 63825 - YWTD domain 57196 - EGF/Laminin | 0 | Direct |
57196,57184,57196 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0 | Direct |
57184,57184,57196 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0 | Direct |
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
57196,49899,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
49854,57196,49854 49854 - Spermadhesin, CUB domain 57196 - EGF/Laminin 49854 - Spermadhesin, CUB domain | 0 | Direct |
57196,57196,90193 57196 - EGF/Laminin 57196 - EGF/Laminin 90193 - Notch domain | 0 | Direct |
90193,90193,90193 90193 - Notch domain 90193 - Notch domain 90193 - Notch domain | 0 | Direct |
57196,57184,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0 | Direct |
50156,50044,52540 50156 - PDZ domain-like 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57850,57850,57850 57850 - RING/U-box 57850 - RING/U-box 57850 - RING/U-box | 0 | Direct |
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | Direct |
57424,57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module 57424 - LDL receptor-like module | 0 | Direct |
57184,52058,49265 57184 - Growth factor receptor domain 52058 - L domain-like 49265 - Fibronectin type III | 0 | Direct |
103575,81296,81296 103575 - Plexin repeat 81296 - E set domains 81296 - E set domains | 0 | Direct |
57196,90193,90193 57196 - EGF/Laminin 90193 - Notch domain 90193 - Notch domain | 0 | Direct |
52058,49265,49265 52058 - L domain-like 49265 - Fibronectin type III 49265 - Fibronectin type III | 0 | Direct |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.002423 | Inherited |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.08707 | Inherited |
57603,57603,57603 57603 - FnI-like domain 57603 - FnI-like domain 57603 - FnI-like domain | 0.2229 | Inherited |
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like | 0.631 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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