L27 domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: L27 domain [ 101287]
• Superfamily: L27 domain [ 101288]
• Family: L27 domain [ 101289] (5)

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Family statistics

	Genomes (70)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	417	1,484	10
Proteins	325	1,126	10

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.4454	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4538	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0	0.4712	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal skull morphology	0	0.8826	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0	0.6771	--	DIRECT
Phenotypic Abnormality (PA)	Neurodevelopmental abnormality	0	0.7381	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal ear morphology	0	1.047	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal ear physiology	0	1.462	--	DIRECT
Phenotypic Abnormality (PA)	Hearing abnormality	1	1.462	--	INHERITED FROM: Hearing impairment
Phenotypic Abnormality (PA)	Abnormality of the face	0	0.533	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	0.513	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.3869	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the ear	0	0.9572	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Neurodevelopmental delay	0	0.9853	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Hearing impairment	0	1.462	Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal excitatory postsynaptic currents	0.0001488	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal respiration	0.0001505	1.427	--	DIRECT
Mammalian Phenotype (MP)	abnormal respiratory system physiology	0.00106	1.281	--	INHERITED FROM: abnormal respiration || abnormal breathing pattern
Mammalian Phenotype (MP)	neonatal lethality	0.001596	1.825	--	INHERITED FROM: neonatal lethality, complete penetrance
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.05394	0.825	--	INHERITED FROM: abnormal excitatory postsynaptic currents
Mammalian Phenotype (MP)	preweaning lethality	0.2634	0.7055	--	INHERITED FROM: neonatal lethality, complete penetrance
Mammalian Phenotype (MP)	abnormal survival	0.3832	0.6441	--	INHERITED FROM: neonatal lethality, complete penetrance
Mammalian Phenotype (MP)	nervous system phenotype	0.001299	0.4959	Least Informative	INHERITED FROM: abnormal excitatory postsynaptic currents
Mammalian Phenotype (MP)	mortality/aging	0.4569	0.5424	Least Informative	INHERITED FROM: neonatal lethality, complete penetrance
Mammalian Phenotype (MP)	respiratory system phenotype	0.006601	0.9404	Moderately Informative	INHERITED FROM: abnormal respiration || abnormal breathing pattern
Mammalian Phenotype (MP)	lethality during fetal growth through weaning	0.05041	1.035	Moderately Informative	INHERITED FROM: neonatal lethality, complete penetrance
Mammalian Phenotype (MP)	abnormal synaptic transmission	0.1981	1.156	Moderately Informative	INHERITED FROM: abnormal excitatory postsynaptic currents
Mammalian Phenotype (MP)	perinatal lethality	0.006035	1.603	Informative	INHERITED FROM: neonatal lethality, complete penetrance
Mammalian Phenotype (MP)	abnormal respiratory function	0.3039	1.562	Informative	INHERITED FROM: abnormal breathing pattern
Mammalian Phenotype (MP)	abnormal CNS synaptic transmission	0.7117	1.281	Informative	INHERITED FROM: abnormal excitatory postsynaptic currents
Mammalian Phenotype (MP)	abnormal breathing pattern	0.0002245	1.758	Highly Informative	DIRECT
Mammalian Phenotype (MP)	neonatal lethality, complete penetrance	0.0002593	2.126	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	viable	0	0.6613	Least Informative	DIRECT
Fly Phenotype (FP)	neuroanatomy defective	0	1.344	Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	embryonic/larval nervous system	0	0.7171	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || nervous system || peripheral nervous system || embryonic/larval nervous system || larva || organ system subdivision || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || organ system subdivision || larva || embryonic/larval nervous system || organism || nervous system || peripheral nervous system
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	nervous system	0	0.6333	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	peripheral nervous system	0	0.8978	Moderately Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism || nervous system
Zebrafish Anatomy (ZA)	nervous system	0	0.7079	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: urogenital system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || trunk || anatomical region || trunk region || organism subdivision
Xenopus ANatomical entity (XAN)	urogenital system	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.7021	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.437	Informative	DIRECT

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