Interferon regulatory factor 3 (IRF3), transactivation domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: SMAD/FHA domain [ 49878]
• Superfamily: SMAD/FHA domain [ 49879] (4)
• Family: Interferon regulatory factor 3 (IRF3), transactivation domain [ 101630]

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Family statistics

	Genomes (45)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	83	191	2
Proteins	82	191	2

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of anatomical entity	0	0.2414	--	DIRECT
Disease Ontology (DO)	disease by infectious agent	0.0001138	0.8142	Moderately Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the immune system	0	0.7464	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of immune system physiology	0	0.8942	Moderately Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	decreased plasmacytoid dendritic cell number	0.000000006063	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal plasmacytoid dendritic cell number	0.00000007246	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal plasmacytoid dendritic cell morphology	0.000000106	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal response to infection	0.0000003042	1.112	--	DIRECT
Mammalian Phenotype (MP)	abnormal interferon secretion	0.0000006336	1.373	--	DIRECT
Mammalian Phenotype (MP)	absent B cells	0.000005944	2.603	--	DIRECT
Mammalian Phenotype (MP)	absent lymphocyte	0.00001935	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal dendritic cell number	0.0000284	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating cytokine level	0.00004079	1.373	--	DIRECT
Mammalian Phenotype (MP)	abnormal dendritic cell morphology	0.00006353	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal intercellular signaling peptide or protein level	0.0001424	1.324	--	DIRECT
Mammalian Phenotype (MP)	increased B cell number	0.0007344	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal spleen white pulp morphology	0.0009998	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal immune system physiology	0.001049	0.6789	--	INHERITED FROM: abnormal circulating cytokine level || abnormal interferon secretion || altered susceptibility to infection || increased susceptibility to viral infection || abnormal immune serum protein physiology || abnormal T cell physiology || abnormal response to infection
Mammalian Phenotype (MP)	abnormal lymphocyte physiology	0.003992	1.112	--	INHERITED FROM: abnormal T cell physiology
Mammalian Phenotype (MP)	altered susceptibility to viral infection	0.005454	2.126	--	INHERITED FROM: increased susceptibility to viral infection
Mammalian Phenotype (MP)	abnormal B cell number	0.005604	1.348	--	INHERITED FROM: increased B cell number || absent B cells || decreased mature B cell number
Mammalian Phenotype (MP)	abnormal mature B cell morphology	0.005707	1.281	--	INHERITED FROM: decreased mature B cell number || absent B cells || increased B cell number
Mammalian Phenotype (MP)	abnormal lymphopoiesis	0.006723	1.205	--	INHERITED FROM: abnormal B cell differentiation
Mammalian Phenotype (MP)	abnormal leukopoiesis	0.01047	1.156	--	INHERITED FROM: abnormal B cell differentiation
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.01581	0.8789	--	INHERITED FROM: abnormal T cell physiology
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.01958	0.8789	--	INHERITED FROM: abnormal T cell physiology
Mammalian Phenotype (MP)	abnormal circulating protein level	0.01978	1.205	--	INHERITED FROM: abnormal circulating cytokine level
Mammalian Phenotype (MP)	abnormal definitive hematopoiesis	0.02115	1.072	--	INHERITED FROM: abnormal B cell differentiation
Mammalian Phenotype (MP)	abnormal hemopoiesis	0.02232	1.072	--	INHERITED FROM: abnormal B cell differentiation
Mammalian Phenotype (MP)	decreased lymphocyte cell number	0.023	1.156	--	INHERITED FROM: absent lymphocyte || decreased mature B cell number || absent B cells
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.02636	0.6893	--	INHERITED FROM: abnormal circulating cytokine level
Mammalian Phenotype (MP)	increased leukocyte cell number	0.02717	1.241	--	INHERITED FROM: increased B cell number
Mammalian Phenotype (MP)	decreased leukocyte cell number	0.04207	1.156	--	INHERITED FROM: absent lymphocyte || absent B cells || decreased plasmacytoid dendritic cell number || decreased mature B cell number
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0.05153	0.9404	--	INHERITED FROM: absent lymphocyte || absent B cells || abnormal B cell differentiation || decreased mature B cell number || increased B cell number
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.08371	0.8473	--	INHERITED FROM: absent lymphocyte || decreased mature B cell number || abnormal B cell differentiation || absent B cells || increased B cell number
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0.08837	0.9129	--	INHERITED FROM: absent lymphocyte || abnormal dendritic cell number || abnormal plasmacytoid dendritic cell number || decreased mature B cell number || absent B cells || decreased dendritic cell number || decreased plasmacytoid dendritic cell number || increased B cell number
Mammalian Phenotype (MP)	abnormal cytokine level	0.1111	1.348	--	INHERITED FROM: abnormal circulating cytokine level
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.1172	0.8108	--	INHERITED FROM: abnormal plasmacytoid dendritic cell number || abnormal B cell differentiation || abnormal plasmacytoid dendritic cell morphology || absent B cells || decreased mature B cell number || absent lymphocyte || abnormal dendritic cell number || abnormal dendritic cell morphology || decreased dendritic cell number || decreased plasmacytoid dendritic cell number || increased B cell number
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.1194	0.8038	--	INHERITED FROM: abnormal dendritic cell number || absent lymphocyte || abnormal plasmacytoid dendritic cell number || absent B cells || abnormal B cell differentiation || abnormal plasmacytoid dendritic cell morphology || decreased mature B cell number || abnormal dendritic cell morphology || decreased dendritic cell number || increased B cell number || decreased plasmacytoid dendritic cell number
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.1227	0.8473	--	INHERITED FROM: decreased plasmacytoid dendritic cell number || increased B cell number || decreased dendritic cell number || absent lymphocyte || abnormal dendritic cell number || absent B cells || decreased mature B cell number || abnormal plasmacytoid dendritic cell number
Mammalian Phenotype (MP)	abnormal cytokine secretion	0.1337	1.085	--	INHERITED FROM: abnormal interferon secretion
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.149	0.3626	--	INHERITED FROM: abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.2143	0.7167	--	INHERITED FROM: abnormal dendritic cell morphology || decreased dendritic cell number || absent lymphocyte || decreased mature B cell number || increased B cell number || decreased plasmacytoid dendritic cell number || abnormal dendritic cell number || abnormal plasmacytoid dendritic cell number || absent B cells || abnormal plasmacytoid dendritic cell morphology || abnormal B cell differentiation
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.4316	0.9219	--	INHERITED FROM: abnormal T cell physiology
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.4397	0.9219	--	INHERITED FROM: abnormal T cell physiology
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.4577	0.9219	--	INHERITED FROM: abnormal T cell physiology
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.6982	0.6686	--	INHERITED FROM: decreased mature B cell number || absent lymphocyte || decreased dendritic cell number || abnormal dendritic cell morphology || abnormal spleen white pulp morphology || abnormal plasmacytoid dendritic cell number || absent B cells || abnormal plasmacytoid dendritic cell morphology || abnormal B cell differentiation || abnormal dendritic cell number || increased B cell number || decreased plasmacytoid dendritic cell number
Mammalian Phenotype (MP)	abnormal immune system morphology	0.8592	0.7223	--	INHERITED FROM: abnormal spleen white pulp morphology || decreased dendritic cell number || abnormal dendritic cell morphology || decreased mature B cell number || absent lymphocyte || increased B cell number || decreased plasmacytoid dendritic cell number || absent B cells || abnormal B cell differentiation || abnormal plasmacytoid dendritic cell morphology || abnormal plasmacytoid dendritic cell number || abnormal dendritic cell number
Mammalian Phenotype (MP)	immune system phenotype	0.006507	0.5462	Least Informative	INHERITED FROM: abnormal circulating cytokine level || increased B cell number || abnormal plasmacytoid dendritic cell number || abnormal B cell differentiation || abnormal plasmacytoid dendritic cell morphology || abnormal T cell physiology || decreased dendritic cell number || abnormal interferon secretion || increased susceptibility to viral infection || decreased plasmacytoid dendritic cell number || altered susceptibility to infection || abnormal dendritic cell number || absent B cells || abnormal response to infection || abnormal dendritic cell morphology || abnormal spleen white pulp morphology || absent lymphocyte || abnormal immune serum protein physiology || decreased mature B cell number
Mammalian Phenotype (MP)	abnormal homeostasis	0.09235	0.4926	Least Informative	INHERITED FROM: abnormal circulating cytokine level || abnormal intercellular signaling peptide or protein level
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.1495	0.5945	Least Informative	INHERITED FROM: abnormal plasmacytoid dendritic cell number || abnormal B cell differentiation || abnormal plasmacytoid dendritic cell morphology || absent B cells || abnormal dendritic cell number || decreased plasmacytoid dendritic cell number || increased B cell number || decreased mature B cell number || absent lymphocyte || abnormal dendritic cell morphology || decreased dendritic cell number || abnormal spleen white pulp morphology || abnormal T cell physiology
Mammalian Phenotype (MP)	altered susceptibility to infection	0.000000198	1.112	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.0000136	1.001	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal B cell morphology	0.007732	1.156	Moderately Informative	INHERITED FROM: increased B cell number || absent B cells || abnormal B cell differentiation || decreased mature B cell number
Mammalian Phenotype (MP)	abnormal protein level	0.01053	1.112	Moderately Informative	INHERITED FROM: abnormal intercellular signaling peptide or protein level || abnormal circulating cytokine level
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.01176	0.9219	Moderately Informative	INHERITED FROM: abnormal T cell physiology
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell morphology	0.02209	1.098	Moderately Informative	INHERITED FROM: decreased dendritic cell number || abnormal dendritic cell morphology || abnormal plasmacytoid dendritic cell number || decreased mature B cell number || absent B cells || increased B cell number || abnormal plasmacytoid dendritic cell morphology || decreased plasmacytoid dendritic cell number || abnormal dendritic cell number
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0.03125	1.059	Moderately Informative	INHERITED FROM: abnormal B cell differentiation
Mammalian Phenotype (MP)	increased hematopoietic cell number	0.04051	1.188	Moderately Informative	INHERITED FROM: increased B cell number
Mammalian Phenotype (MP)	abnormal lymphocyte cell number	0.04153	1.023	Moderately Informative	INHERITED FROM: absent B cells || decreased mature B cell number || absent lymphocyte || increased B cell number
Mammalian Phenotype (MP)	abnormal immune system organ morphology	0.04496	1.112	Moderately Informative	INHERITED FROM: abnormal spleen white pulp morphology
Mammalian Phenotype (MP)	decreased hematopoietic cell number	0.06487	1.072	Moderately Informative	INHERITED FROM: decreased dendritic cell number || decreased plasmacytoid dendritic cell number || absent B cells || decreased mature B cell number || absent lymphocyte
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.1017	0.9129	Moderately Informative	INHERITED FROM: abnormal B cell differentiation
Mammalian Phenotype (MP)	abnormal T cell physiology	0.0007174	1.427	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal B cell differentiation	0.000976	1.373	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal mature B cell number	0.001094	1.603	Informative	INHERITED FROM: decreased mature B cell number
Mammalian Phenotype (MP)	decreased B cell number	0.002565	1.562	Informative	INHERITED FROM: absent B cells || decreased mature B cell number
Mammalian Phenotype (MP)	increased lymphocyte cell number	0.009569	1.524	Informative	INHERITED FROM: increased B cell number
Mammalian Phenotype (MP)	abnormal spleen morphology	0.02071	1.427	Informative	INHERITED FROM: abnormal spleen white pulp morphology
Mammalian Phenotype (MP)	increased susceptibility to infection	0.4634	1.324	Informative	INHERITED FROM: increased susceptibility to viral infection
Mammalian Phenotype (MP)	increased susceptibility to viral infection	0.000000003719	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased dendritic cell number	0.000005944	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased mature B cell number	0.0004696	1.758	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT

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