PAZ domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: SH3-like barrel [ 50036] (21)
• Superfamily: PAZ domain [ 101690]
• Family: PAZ domain [ 101691] (5)

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Family statistics

	Genomes (227)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	950	2,649	7
Proteins	947	2,643	7

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of cellular proliferation	0	0.2322	--	DIRECT
Disease Ontology (DO)	cancer	0	0.2555	--	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal meiosis	0.00000004084	1.904	--	DIRECT
Mammalian Phenotype (MP)	epidermal cyst	0.00000004376	2.603	--	DIRECT
Mammalian Phenotype (MP)	hair follicle degeneration	0.0000003395	2.603	--	DIRECT
Mammalian Phenotype (MP)	decreased testis weight	0.0000004456	2.302	--	DIRECT
Mammalian Phenotype (MP)	decreased germ cell number	0.000008763	1.562	--	DIRECT
Mammalian Phenotype (MP)	abnormal hair follicle development	0.00001466	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal male germ cell morphology	0.00001781	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal testis size	0.00002211	1.649	--	DIRECT
Mammalian Phenotype (MP)	small gonad	0.00002456	1.649	--	DIRECT
Mammalian Phenotype (MP)	abnormal sex determination	0.00003969	1.348	--	DIRECT
Mammalian Phenotype (MP)	abnormal gametogenesis	0.0001094	1.324	--	DIRECT
Mammalian Phenotype (MP)	abnormal male reproductive gland morphology	0.0001233	1.427	--	DIRECT
Mammalian Phenotype (MP)	abnormal internal male genitalia morphology	0.0001573	1.373	--	DIRECT
Mammalian Phenotype (MP)	abnormal male reproductive system morphology	0.0001796	1.348	--	DIRECT
Mammalian Phenotype (MP)	abnormal hair follicle morphology	0.000424	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal skin condition	0.0006249	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal gland morphology	0.002141	0.7519	--	INHERITED FROM: abnormal testis size || small testis || decreased testis weight || abnormal male reproductive gland morphology || abnormal testis weight || abnormal testis morphology
Mammalian Phenotype (MP)	abnormal cell morphology	0.004997	1.324	--	INHERITED FROM: decreased male germ cell number || abnormal male germ cell morphology || abnormal germ cell morphology || decreased germ cell number
Mammalian Phenotype (MP)	reproductive system phenotype	0.0112	0.8397	--	INHERITED FROM: abnormal sex determination || decreased male germ cell number || abnormal internal male genitalia morphology || abnormal male reproductive system morphology || abnormal male germ cell morphology || abnormal meiosis || abnormal testis morphology || small gonad || abnormal spermatogenesis || decreased testis weight || small testis || abnormal male reproductive system physiology || decreased germ cell number || abnormal gametogenesis || abnormal testis size || abnormal primary sex determination || abnormal male reproductive gland morphology || abnormal testis weight || abnormal germ cell morphology
Mammalian Phenotype (MP)	abnormal sex gland morphology	0.01581	1.141	--	INHERITED FROM: abnormal testis size || small testis || abnormal testis morphology || abnormal male reproductive gland morphology || decreased testis weight || abnormal testis weight
Mammalian Phenotype (MP)	integument phenotype	0.1498	0.797	--	INHERITED FROM: thick epidermis || epidermal cyst || abnormal hair follicle development || abnormal hair follicle morphology || hair follicle degeneration || abnormal skin condition
Mammalian Phenotype (MP)	abnormal male genitalia morphology	1	1.348	--	INHERITED FROM: abnormal internal male genitalia morphology || abnormal testis weight || decreased testis weight || abnormal testis morphology || small testis || abnormal testis size
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0.003256	0.6947	Least Informative	INHERITED FROM: decreased testis weight || abnormal male reproductive gland morphology || abnormal testis size || small testis || abnormal testis weight || abnormal testis morphology
Mammalian Phenotype (MP)	cellular phenotype	0.03373	0.5387	Least Informative	INHERITED FROM: abnormal male germ cell morphology || decreased male germ cell number || abnormal germ cell morphology || decreased germ cell number
Mammalian Phenotype (MP)	abnormal reproductive system morphology	0.00157	0.9404	Moderately Informative	INHERITED FROM: decreased germ cell number || abnormal gametogenesis || small testis || abnormal testis size || decreased testis weight || abnormal primary sex determination || abnormal male reproductive gland morphology || abnormal germ cell morphology || abnormal testis weight || abnormal sex determination || abnormal internal male genitalia morphology || abnormal male reproductive system morphology || abnormal male germ cell morphology || decreased male germ cell number || small gonad || abnormal testis morphology || abnormal meiosis || abnormal spermatogenesis
Mammalian Phenotype (MP)	abnormal reproductive system physiology	0.004698	1.012	Moderately Informative	INHERITED FROM: abnormal male reproductive system physiology
Mammalian Phenotype (MP)	abnormal skin morphology	0.02799	1.188	Moderately Informative	INHERITED FROM: abnormal skin condition || epidermal cyst || thick epidermis
Mammalian Phenotype (MP)	abnormal skin adnexa morphology	0.03577	1.156	Moderately Informative	INHERITED FROM: hair follicle degeneration || abnormal hair follicle morphology || abnormal hair follicle development
Mammalian Phenotype (MP)	abnormal primary sex determination	0.000029	1.524	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal spermatogenesis	0.00003576	1.489	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal germ cell morphology	0.00003795	1.524	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal testis morphology	0.00006473	1.427	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal male reproductive system physiology	0.0002839	1.7	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal epidermal layer morphology	0.001834	1.562	Informative	INHERITED FROM: thick epidermis
Mammalian Phenotype (MP)	abnormal testis weight	0.0000006566	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased male germ cell number	0.000004289	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	small testis	0.00001588	1.758	Highly Informative	DIRECT
Mammalian Phenotype (MP)	thick epidermis	0.00003827	2.001	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	21U RNA expression variant	0.00000000001941	2.769	--	DIRECT
Worm Phenotype (WP)	RNAi response variant	0.000000008855	1.769	--	DIRECT
Worm Phenotype (WP)	siRNA expression variant	0.000006011	2.769	--	DIRECT
Worm Phenotype (WP)	RNAi enhanced	0.0001217	2.769	--	DIRECT
Worm Phenotype (WP)	somatic transgene silencing variant	0.0001867	2.292	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0.027	0.6256	--	INHERITED FROM: siRNA expression variant || 21U RNA expression variant || RNA expression variant || mRNA levels increased
Worm Phenotype (WP)	transgene silencing variant	0.8258	2.292	--	INHERITED FROM: somatic transgene silencing variant
Worm Phenotype (WP)	mRNA expression variant	1	1.814	--	INHERITED FROM: mRNA levels increased
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: RNAi response variant || RNAi enhanced || siRNA expression variant || RNA expression variant || maintenance of gene silencing variant || lethal || 21U RNA expression variant || development variant || somatic transgene silencing variant || mRNA levels increased || organism development variant
Worm Phenotype (WP)	organism physiology variant	1	0.1342	--	INHERITED FROM: mRNA levels increased || RNAi enhanced || siRNA expression variant || 21U RNA expression variant || somatic transgene silencing variant || RNA expression variant || maintenance of gene silencing variant || RNAi response variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	1	0.1444	--	INHERITED FROM: mRNA levels increased || siRNA expression variant || RNAi enhanced || maintenance of gene silencing variant || RNA expression variant || 21U RNA expression variant || somatic transgene silencing variant || RNAi response variant
Worm Phenotype (WP)	organism metabolism processing variant	0.09626	0.4899	Least Informative	INHERITED FROM: mRNA levels increased || siRNA expression variant || RNA expression variant || 21U RNA expression variant
Worm Phenotype (WP)	RNA expression variant	0.000000000000998	1.565	Informative	DIRECT
Worm Phenotype (WP)	maintenance of gene silencing variant	0.00000001581	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	mRNA levels increased	0.0001652	2.167	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0.5797	0.06546	--	INHERITED FROM: modifier of variegation || mitotic cell cycle defective || cell cycle defective || suppressor of variegation
Fly Phenotype (FP)	modifier of variegation	0.000001384	1.687	Informative	DIRECT
Fly Phenotype (FP)	cell cycle defective	0.0002461	1.541	Informative	DIRECT
Fly Phenotype (FP)	suppressor of variegation	0.0000006341	2.085	Highly Informative	DIRECT
Fly Phenotype (FP)	mitotic cell cycle defective	0.00007878	1.784	Highly Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || egg || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure || egg || organism
Fly Anatomy (FA)	egg	0.0007083	1.69	Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || trunk || anatomical region || trunk region || organism subdivision
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3087	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Endoribonucleases producing 5'-phosphomonoesters	0	1.767	--	DIRECT
Enzyme Commission (EC)	Argonaute-2	0	3.23	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.8756	Moderately Informative	DIRECT

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