Serum paraoxonase/arylesterase 1, PON1 family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: 6-bladed beta-propeller [ 50938] (11)
• Superfamily: Calcium-dependent phosphotriesterase [ 63829] (3)
• Family: Serum paraoxonase/arylesterase 1, PON1 [ 101895]

---

Family statistics

	Genomes (75)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	197	457	1
Proteins	195	456	1

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Phosphoric triester hydrolases	0	2.741	--	DIRECT
Enzyme Commission (EC)	Aryldialkylphosphatase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Arylesterase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Quorum-quenching N-acyl-homoserine lactonase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.5107	Least Informative	DIRECT
Enzyme Commission (EC)	Carboxylic ester hydrolases	0	1.21	Moderately Informative	DIRECT

---

Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	autoimmune disease of gastrointestinal tract	0	2.036	--	DIRECT
Disease Ontology (DO)	hypersensitivity reaction disease	0	0.8505	--	DIRECT
Disease Ontology (DO)	cardiovascular system disease	0	0.7889	--	DIRECT
Disease Ontology (DO)	vascular disease	0	0.832	--	DIRECT
Disease Ontology (DO)	motor neuron disease	0	1.911	--	DIRECT
Disease Ontology (DO)	immune system disease	0	0.8411	--	DIRECT
Disease Ontology (DO)	central nervous system disease	0	0.8698	--	DIRECT
Disease Ontology (DO)	disease of anatomical entity	0	0.2414	--	DIRECT
Disease Ontology (DO)	nervous system disease	0	0.7279	Least Informative	DIRECT
Disease Ontology (DO)	artery disease	0	0.9817	Moderately Informative	DIRECT
Disease Ontology (DO)	neurodegenerative disease	0	1.022	Moderately Informative	DIRECT
Disease Ontology (DO)	hypersensitivity reaction type II disease	0	0.8797	Moderately Informative	DIRECT
Disease Ontology (DO)	heart disease	0	1.472	Informative	DIRECT
Disease Ontology (DO)	coronary artery disease	0	1.472	Informative	DIRECT
Disease Ontology (DO)	celiac disease	0	2.036	Highly Informative	DIRECT
Disease Ontology (DO)	lateral sclerosis	0	2.212	Highly Informative	DIRECT
Disease Ontology (DO)	amyotrophic lateral sclerosis	0	2.036	Highly Informative	DIRECT

---

Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormal motor neuron morphology	0	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.4454	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal neuron morphology	0	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Laryngospasm	0	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Xerostomia	0	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal synaptic transmission	0	1.684	--	DIRECT
Phenotypic Abnormality (PA)	Spasticity	0	1.684	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal fear/anxiety-related behavior	0	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Muscle spasm	0	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Restlessness	0	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Atrophy/Degeneration affecting the central nervous system	0	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the respiratory system	0	0.9183	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the larynx	0	1.86	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4538	--	DIRECT
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0	0.533	--	DIRECT
Phenotypic Abnormality (PA)	Fatigable weakness of bulbar muscles	0	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the mouth	0	0.7065	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of salivation	0	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Upper motor neuron dysfunction	0	1.286	--	DIRECT
Phenotypic Abnormality (PA)	Fatigable weakness	0	1.684	--	DIRECT
Phenotypic Abnormality (PA)	Neurodegeneration	0	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Constitutional symptom	0	1.258	--	DIRECT
Phenotypic Abnormality (PA)	Abdominal symptom	0	1.161	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0	0.6915	--	DIRECT
Phenotypic Abnormality (PA)	Respiratory failure	0	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle tone	0	0.8942	--	DIRECT
Phenotypic Abnormality (PA)	Amyotrophic lateral sclerosis	0	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal peripheral nervous system synaptic transmission	1	1.684	--	INHERITED FROM: Fatigable weakness || Fatigable weakness of swallowing muscles || Fatigable weakness of bulbar muscles || Fatigable weakness of respiratory muscles
Phenotypic Abnormality (PA)	Abnormality of the face	0	0.533	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0	0.5759	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature	0	0.5433	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0	0.4756	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.3869	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of digestive system physiology	0	0.9572	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of central motor function	0	1.047	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal respiratory system morphology	0	1.064	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Behavioral abnormality	0	1.082	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal skeletal muscle morphology	0	0.9061	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Impairment in personality functioning	0	1.508	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the upper respiratory tract	0	1.508	Informative	DIRECT
Phenotypic Abnormality (PA)	Pain	0	1.383	Informative	DIRECT
Phenotypic Abnormality (PA)	Fatigue	0	1.684	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of muscle size	0	1.684	Informative	DIRECT
Phenotypic Abnormality (PA)	Functional respiratory abnormality	0	1.348	Informative	DIRECT
Phenotypic Abnormality (PA)	Nausea and vomiting	0	1.508	Informative	DIRECT
Phenotypic Abnormality (PA)	Muscle weakness	0	1.316	Informative	DIRECT
Phenotypic Abnormality (PA)	Hypertonia	0	1.508	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal synaptic transmission at the neuromuscular junction	1	1.684	Informative	INHERITED FROM: Fatigable weakness of respiratory muscles || Fatigable weakness of bulbar muscles || Fatigable weakness of swallowing muscles || Fatigable weakness
Phenotypic Abnormality (PA)	Fatigable weakness of respiratory muscles	0	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Anxiety	0	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Respiratory insufficiency	0	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Generalized muscle weakness	0	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal larynx physiology	0	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Fatigable weakness of swallowing muscles	0	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Dyspnea	0	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Emotional lability	0	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Depressivity	0	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal oral physiology	0	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Paralysis	0	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Skeletal muscle atrophy	0	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Agitation	0	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Motor neuron atrophy	0	2.161	Highly Informative	DIRECT

---

Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal redox activity	0	2.302	--	DIRECT
Mammalian Phenotype (MP)	oxidative stress	0	2.603	--	DIRECT
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0	0.3626	--	DIRECT
Mammalian Phenotype (MP)	abnormal cell physiology	0	0.6209	--	DIRECT
Mammalian Phenotype (MP)	abnormal homeostasis	0	0.4926	Least Informative	DIRECT
Mammalian Phenotype (MP)	cellular phenotype	0	0.5387	Least Informative	DIRECT

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	sterile progeny	0	0.6547	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile || sterile progeny
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || retarded heterochronic variations || larval lethal || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || larval development variant || sterile progeny || organism physiology variant || progeny variant || slow growth || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || general pace of development variant || fertility variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	progeny variant	0	0.6514	Least Informative	DIRECT
Worm Phenotype (WP)	larval lethal	0	0.5727	Least Informative	DIRECT
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Arylesterase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Quorum-quenching N-acyl-homoserine lactonase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Phosphoric triester hydrolases	0	3.23	--	DIRECT
Enzyme Commission (EC)	Aryldialkylphosphatase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	Carboxylic ester hydrolases	0	1.539	Informative	DIRECT

---