Sema domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: 7-bladed beta-propeller [ 50964] (14)
• Superfamily: Sema domain [ 101912]
• Family: Sema domain [ 101913] (3)

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Family statistics

	Genomes (135)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,823	7,646	3
Proteins	2,789	7,610	3

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Protein-tyrosine kinases	0	1.361	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2728	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Receptor protein-tyrosine kinase	0	1.595	Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal dominant inheritance	0	0.516	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Neoplasm by anatomical site	0.0139	1.184	--	INHERITED FROM: Neoplasm of the thyroid gland
Phenotypic Abnormality (PA)	Neoplasm of the endocrine system	0.01514	1.763	--	INHERITED FROM: Neoplasm of the thyroid gland
Phenotypic Abnormality (PA)	Abnormality of thyroid morphology	0.07923	1.684	--	INHERITED FROM: Neoplasm of the thyroid gland
Phenotypic Abnormality (PA)	Abnormality of the head	0.3744	0.4538	--	INHERITED FROM: Abnormality of the sense of smell
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.3848	0.4454	--	INHERITED FROM: Abnormality of the sense of smell
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.4275	0.2371	--	INHERITED FROM: Abnormality of the sense of smell
Phenotypic Abnormality (PA)	Abnormality of the face	0.2758	0.533	Least Informative	INHERITED FROM: Abnormality of the sense of smell
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0.3083	0.3869	Least Informative	INHERITED FROM: Abnormality of the sense of smell
Phenotypic Abnormality (PA)	Abnormality of the endocrine system	0.01299	0.9183	Moderately Informative	INHERITED FROM: Neoplasm of the thyroid gland
Phenotypic Abnormality (PA)	Neoplasm	0.01717	1.14	Moderately Informative	INHERITED FROM: Neoplasm of the thyroid gland
Phenotypic Abnormality (PA)	Abnormality of the nose	0.02602	1.258	Informative	INHERITED FROM: Abnormality of the sense of smell
Phenotypic Abnormality (PA)	Abnormality of the thyroid gland	0.05703	1.617	Informative	INHERITED FROM: Neoplasm of the thyroid gland
Phenotypic Abnormality (PA)	Neoplasm of the thyroid gland	0.0001626	1.763	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the sense of smell	0.0004205	2.161	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	ectopic cerebellar granule cells	0.0000000003128	2.302	--	DIRECT
Mammalian Phenotype (MP)	increased susceptibility to kidney reperfusion injury	0.00000004581	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal cerebellar granule cell morphology	0.000000216	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal retinal inner plexiform layer morphology	0.000001699	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal cerebellar granule layer morphology	0.000007758	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.00001413	0.5861	--	DIRECT
Mammalian Phenotype (MP)	abnormal kidney epithelium morphology	0.00002264	2.126	--	DIRECT
Mammalian Phenotype (MP)	abnormal hippocampal mossy fiber morphology	0.00002953	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal retina morphology	0.00009584	1.241	--	DIRECT
Mammalian Phenotype (MP)	abnormal ocular fundus morphology	0.0001037	1.241	--	DIRECT
Mammalian Phenotype (MP)	abnormal telencephalon morphology	0.000122	1.261	--	DIRECT
Mammalian Phenotype (MP)	abnormal cerebellar cortex morphology	0.0002674	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal brain commissure morphology	0.0003234	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal trochlear nerve morphology	0.0003449	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal branching involved in ureteric bud morphogenesis	0.0009337	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal cerebellum morphology	0.0009498	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal ureteric bud morphology	0.001374	2.126	--	INHERITED FROM: abnormal branching involved in ureteric bud morphogenesis
Mammalian Phenotype (MP)	abnormal posterior eye segment morphology	0.007068	1.223	--	INHERITED FROM: abnormal amacrine cell morphology || abnormal retina morphology || abnormal retinal neuronal layer morphology || abnormal ocular fundus morphology || abnormal retinal inner plexiform layer morphology
Mammalian Phenotype (MP)	vision/eye phenotype	0.01087	0.8789	--	INHERITED FROM: abnormal retina morphology || abnormal retinal inner plexiform layer morphology || abnormal retinal neuronal layer morphology || abnormal ocular fundus morphology || abnormal amacrine cell morphology
Mammalian Phenotype (MP)	renal/urinary system phenotype	0.0405	0.931	--	INHERITED FROM: increased susceptibility to kidney reperfusion injury || altered susceptibility to kidney reperfusion injury || abnormal kidney epithelium morphology || abnormal branching involved in ureteric bud morphogenesis || abnormal renal tubule epithelium morphology
Mammalian Phenotype (MP)	abnormal sensory neuron morphology	0.05097	1.156	--	INHERITED FROM: abnormal amacrine cell morphology
Mammalian Phenotype (MP)	abnormal somatic nervous system morphology	0.05108	0.931	--	INHERITED FROM: abnormal trochlear nerve morphology || abnormal amacrine cell morphology
Mammalian Phenotype (MP)	abnormal cell physiology	0.07177	0.6209	--	INHERITED FROM: abnormal cell migration || abnormal neuronal migration
Mammalian Phenotype (MP)	abnormal nephron morphology	0.0796	1.261	--	INHERITED FROM: abnormal renal tubule epithelium morphology
Mammalian Phenotype (MP)	abnormal hindbrain morphology	0.1275	1.649	--	INHERITED FROM: abnormal cerebellar cortex morphology || abnormal cerebellar granule layer morphology || abnormal cerebellum morphology || abnormal cerebellar granule cell morphology || ectopic cerebellar granule cells
Mammalian Phenotype (MP)	abnormal forebrain morphology	0.1467	1.188	--	INHERITED FROM: abnormal hippocampal mossy fiber morphology || abnormal telencephalon morphology
Mammalian Phenotype (MP)	abnormal retinal layer morphology	0.1567	1.399	--	INHERITED FROM: abnormal retinal inner plexiform layer morphology || abnormal retinal neuronal layer morphology
Mammalian Phenotype (MP)	abnormal hippocampus morphology	0.2315	1.7	--	INHERITED FROM: abnormal hippocampal mossy fiber morphology
Mammalian Phenotype (MP)	abnormal renal/urinary system physiology	0.45	1.281	--	INHERITED FROM: increased susceptibility to kidney reperfusion injury || altered susceptibility to kidney reperfusion injury
Mammalian Phenotype (MP)	abnormal temporal lobe morphology	0.4672	1.7	--	INHERITED FROM: abnormal hippocampal mossy fiber morphology
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.6323	0.825	--	INHERITED FROM: abnormal neuronal migration
Mammalian Phenotype (MP)	abnormal kidney morphology	0.6358	1.156	--	INHERITED FROM: abnormal kidney epithelium morphology || abnormal renal tubule epithelium morphology
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	1	0.3626	--	INHERITED FROM: increased susceptibility to kidney reperfusion injury || altered susceptibility to kidney reperfusion injury
Mammalian Phenotype (MP)	nervous system phenotype	0.0003228	0.4959	Least Informative	DIRECT
Mammalian Phenotype (MP)	cellular phenotype	0.1586	0.5387	Least Informative	INHERITED FROM: abnormal neuronal migration || abnormal cell migration
Mammalian Phenotype (MP)	abnormal neuron morphology	0.00232	0.8323	Moderately Informative	INHERITED FROM: ectopic cerebellar granule cells || ectopic neuron || abnormal amacrine cell morphology
Mammalian Phenotype (MP)	abnormal eye morphology	0.006331	0.9129	Moderately Informative	INHERITED FROM: abnormal amacrine cell morphology || abnormal retina morphology || abnormal retinal inner plexiform layer morphology || abnormal retinal neuronal layer morphology || abnormal ocular fundus morphology
Mammalian Phenotype (MP)	abnormal renal/urinary system morphology	0.01215	1.047	Moderately Informative	INHERITED FROM: abnormal kidney epithelium morphology || abnormal renal tubule epithelium morphology || abnormal branching involved in ureteric bud morphogenesis
Mammalian Phenotype (MP)	abnormal somatic sensory system morphology	0.2873	1.023	Moderately Informative	INHERITED FROM: abnormal amacrine cell morphology
Mammalian Phenotype (MP)	abnormal brain morphology	0.4243	0.9799	Moderately Informative	INHERITED FROM: abnormal cerebellar granule layer morphology || abnormal cerebellum morphology || abnormal cerebellar granule cell morphology || abnormal hippocampal mossy fiber morphology || abnormal brain commissure morphology || ectopic cerebellar granule cells || abnormal telencephalon morphology || abnormal cerebellar cortex morphology
Mammalian Phenotype (MP)	abnormal retinal neuronal layer morphology	0.00002168	1.427	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cell migration	0.00008708	1.399	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal metencephalon morphology	0.001462	1.649	Informative	INHERITED FROM: abnormal cerebellum morphology || abnormal cerebellar granule layer morphology || abnormal cerebellar cortex morphology || ectopic cerebellar granule cells || abnormal cerebellar granule cell morphology
Mammalian Phenotype (MP)	abnormal neuron physiology	0.007211	1.524	Informative	INHERITED FROM: abnormal neuronal migration
Mammalian Phenotype (MP)	abnormal kidney physiology	0.01406	1.427	Informative	INHERITED FROM: altered susceptibility to kidney reperfusion injury || increased susceptibility to kidney reperfusion injury
Mammalian Phenotype (MP)	abnormal nervous system tract morphology	0.02505	1.649	Informative	INHERITED FROM: abnormal brain commissure morphology
Mammalian Phenotype (MP)	abnormal brain white matter morphology	0.0277	1.7	Informative	INHERITED FROM: abnormal brain commissure morphology
Mammalian Phenotype (MP)	abnormal response to injury	0.04482	1.261	Informative	INHERITED FROM: altered susceptibility to kidney reperfusion injury || increased susceptibility to kidney reperfusion injury
Mammalian Phenotype (MP)	abnormal limbic system morphology	0.07484	1.7	Informative	INHERITED FROM: abnormal hippocampal mossy fiber morphology
Mammalian Phenotype (MP)	abnormal renal tubule morphology	0.08749	1.649	Informative	INHERITED FROM: abnormal renal tubule epithelium morphology
Mammalian Phenotype (MP)	abnormal cerebral hemisphere morphology	0.1149	1.524	Informative	INHERITED FROM: abnormal hippocampal mossy fiber morphology
Mammalian Phenotype (MP)	abnormal cranial nerve morphology	0.3129	1.649	Informative	INHERITED FROM: abnormal trochlear nerve morphology
Mammalian Phenotype (MP)	abnormal renal tubule epithelium morphology	0.0000009593	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal amacrine cell morphology	0.000003272	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	altered susceptibility to kidney reperfusion injury	0.000004786	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal neuronal migration	0.0002321	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	ectopic neuron	0.0005833	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal urinary system development	0.08288	1.904	Highly Informative	INHERITED FROM: abnormal branching involved in ureteric bud morphogenesis
Mammalian Phenotype (MP)	abnormal cerebellar layer morphology	0.567	2.001	Highly Informative	INHERITED FROM: abnormal cerebellar granule layer morphology || abnormal cerebellar granule cell morphology || ectopic cerebellar granule cells

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0	0.7516	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	nervous system morphology variant	0	1.321	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	sexually dimorphic morphology variant	0	1.655	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	male nervous system morphology variant	0	1.99	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	vulva uterus connection defective	0.000000001377	1.866	--	DIRECT
Worm Phenotype (WP)	neuronal outgrowth variant	0.0000000598	1.565	--	DIRECT
Worm Phenotype (WP)	neuron development variant	0.000001377	1.321	--	DIRECT
Worm Phenotype (WP)	reproductive system development variant	0.00001394	1.156	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || organ system development variant || axon guidance variant || lethal || anchor cell invasion variant || development variant || reproductive system development variant || hermaphrodite sterile || hermaphrodite fertility reduced || axon outgrowth variant || embryonic development variant || embryonic lethal || vulva uterus connection defective || fertility variant || neuronal outgrowth variant || organ system physiology variant || maternal sterile || neuron development variant || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	cell development variant	0.001895	0.6752	Least Informative	INHERITED FROM: axon guidance variant || axon outgrowth variant || neuronal outgrowth variant || neuron development variant
Worm Phenotype (WP)	organ system development variant	0.0002252	0.9113	Moderately Informative	DIRECT
Worm Phenotype (WP)	sensillum morphology variant	0	1.593	Informative	DIRECT
Worm Phenotype (WP)	male morphology variant	0	1.655	Informative	DIRECT
Worm Phenotype (WP)	axon outgrowth variant	0.00000005028	1.565	Informative	DIRECT
Worm Phenotype (WP)	male ray morphology variant	0	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	anchor cell invasion variant	0.000000000889	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	axon guidance variant	0.000000006549	1.866	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	behavior defective	0	1.306	Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	abdominal segment	0	1.243	--	DIRECT
Fly Anatomy (FA)	larval abdomen	0	1.389	--	DIRECT
Fly Anatomy (FA)	embryonic/larval nervous system	0	0.7171	--	DIRECT
Fly Anatomy (FA)	embryonic/larval central nervous system	0	1.275	--	DIRECT
Fly Anatomy (FA)	segmental nerve	0	2.088	--	DIRECT
Fly Anatomy (FA)	abdominal nerve	0	1.787	--	DIRECT
Fly Anatomy (FA)	adult nervous system	0	0.7764	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	neuron projection bundle	0	1.243	--	DIRECT
Fly Anatomy (FA)	sensory neuron	0	1.213	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	organism subdivision	0	0.5027	--	DIRECT
Fly Anatomy (FA)	non-connected functional system	0	0.8451	--	DIRECT
Fly Anatomy (FA)	sensory system	0	0.8577	--	DIRECT
Fly Anatomy (FA)	sensory system neuron	0	1.213	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	ipsilateral tract	0.00003613	1.787	--	DIRECT
Fly Anatomy (FA)	presumptive embryonic/larval nervous system	0.0001145	1.787	--	DIRECT
Fly Anatomy (FA)	tract neuropil	0.0007494	1.486	--	DIRECT
Fly Anatomy (FA)	non-connected developing system	0.009617	1.389	--	INHERITED FROM: presumptive embryonic/larval central nervous system || presumptive embryonic/larval nervous system
Fly Anatomy (FA)	developing embryonic structure	0.02525	1.243	--	INHERITED FROM: presumptive embryonic/larval nervous system || presumptive embryonic/larval central nervous system
Fly Anatomy (FA)	embryo	0.08647	0.8978	--	INHERITED FROM: presumptive embryonic/larval nervous system || presumptive embryonic/larval central nervous system
Fly Anatomy (FA)	neuropil	0.1329	1.243	--	INHERITED FROM: fascicle || tract neuropil || ipsilateral tract || connective
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: sensory neuron || larval abdominal segment || organism || nervous system || ventral nerve cord || peripheral nervous system || abdomen || connective || abdominal segmental nerve || neuron || adult || embryonic/larval nervous system || adult nervous system || embryonic/larval central nervous system || segmental nerve || segment || larva || somatic cell || larval abdomen || neuron projection bundle of ventral nerve cord || presumptive embryonic/larval central nervous system || presumptive embryonic/larval nervous system || nerve || cell || larval tagma || abdominal segment || multi-tissue structure || larval segment || fascicle || tagma || organ system subdivision || multi-cell-component structure || sensory system neuron || central nervous system || neuron projection bundle || ipsilateral tract || tract neuropil || embryonic/larval peripheral nervous system || organ system || ganglion || abdominal nerve || organism subdivision || multicellular structure || intersegmental nerve
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: ipsilateral tract || anatomical group || tract neuropil || embryonic/larval peripheral nervous system || organ system || ganglion || abdominal nerve || organism subdivision || multicellular structure || intersegmental nerve || developing material anatomical entity || sensory system || sensory system neuron || central nervous system || neuron projection bundle || fascicle || non-connected functional system || tagma || organ system subdivision || multi-cell-component structure || nerve || larval tagma || cell || abdominal segment || larval segment || multi-tissue structure || neuron projection bundle of ventral nerve cord || presumptive embryonic/larval central nervous system || presumptive embryonic/larval nervous system || embryonic/larval central nervous system || segmental nerve || segment || larva || somatic cell || larval abdomen || connective || abdominal segmental nerve || neuron || adult || embryonic/larval nervous system || adult nervous system || sensory neuron || larval abdominal segment || organism || nervous system || ventral nerve cord || peripheral nervous system || abdomen
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: larval segment || abdomen || larval tagma || abdominal segment || larval abdominal segment || tagma || abdominal segmental nerve || larval abdomen || segment || abdominal nerve
Fly Anatomy (FA)	tagma	0	0.5027	Least Informative	DIRECT
Fly Anatomy (FA)	segment	0	0.6568	Least Informative	DIRECT
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	nervous system	0	0.6333	Least Informative	DIRECT
Fly Anatomy (FA)	multi-tissue structure	0	0.6038	Least Informative	DIRECT
Fly Anatomy (FA)	anatomical group	0	0.6816	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT
Fly Anatomy (FA)	abdomen	0	1.185	Moderately Informative	DIRECT
Fly Anatomy (FA)	larval tagma	0	1.159	Moderately Informative	DIRECT
Fly Anatomy (FA)	larval segment	0	1.243	Moderately Informative	DIRECT
Fly Anatomy (FA)	central nervous system	0	1.009	Moderately Informative	DIRECT
Fly Anatomy (FA)	peripheral nervous system	0	0.8978	Moderately Informative	DIRECT
Fly Anatomy (FA)	neuron	0	0.8451	Moderately Informative	DIRECT
Fly Anatomy (FA)	ganglion	0	1.185	Moderately Informative	DIRECT
Fly Anatomy (FA)	developing material anatomical entity	0	0.8329	Moderately Informative	DIRECT
Fly Anatomy (FA)	multi-cell-component structure	0	1.088	Moderately Informative	DIRECT
Fly Anatomy (FA)	ventral nerve cord	0	1.31	Informative	DIRECT
Fly Anatomy (FA)	larval abdominal segment	0	1.486	Informative	DIRECT
Fly Anatomy (FA)	nerve	0	1.389	Informative	DIRECT
Fly Anatomy (FA)	embryonic/larval peripheral nervous system	0	1.544	Informative	DIRECT
Fly Anatomy (FA)	presumptive embryonic/larval system	0.002834	1.389	Informative	INHERITED FROM: presumptive embryonic/larval central nervous system || presumptive embryonic/larval nervous system
Fly Anatomy (FA)	tract	0.1876	1.486	Informative	INHERITED FROM: ipsilateral tract || fascicle || connective
Fly Anatomy (FA)	intersegmental nerve	0	1.912	Highly Informative	DIRECT
Fly Anatomy (FA)	abdominal segmental nerve	0	2.088	Highly Informative	DIRECT
Fly Anatomy (FA)	fascicle	0.0000006468	2.088	Highly Informative	DIRECT
Fly Anatomy (FA)	connective	0.00001956	1.912	Highly Informative	DIRECT
Fly Anatomy (FA)	presumptive embryonic/larval central nervous system	0.00004505	1.787	Highly Informative	DIRECT
Fly Anatomy (FA)	neuron projection bundle of ventral nerve cord	0.0007416	1.912	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	CaP motoneuron	0.000002055	2.17	--	DIRECT
Zebrafish Anatomy (ZA)	primary motor neuron	0.00001918	2.17	--	DIRECT
Zebrafish Anatomy (ZA)	neuron neural crest derived	0.00006396	1.994	--	DIRECT
Zebrafish Anatomy (ZA)	neuroectoderm	0.0001519	2.17	--	DIRECT
Zebrafish Anatomy (ZA)	primary neuron	0.0008936	2.17	--	DIRECT
Zebrafish Anatomy (ZA)	electrically signaling cell	0.01053	1.568	--	INHERITED FROM: CaP motoneuron || primary neuron || primary motor neuron
Zebrafish Anatomy (ZA)	primary germ layer	0.01431	1.869	--	INHERITED FROM: primary neuron || neuroectoderm || ectoderm || CaP motoneuron || primary motor neuron
Zebrafish Anatomy (ZA)	efferent neuron	0.04574	1.994	--	INHERITED FROM: primary motor neuron || CaP motoneuron
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || primary neuron || primary motor neuron || ectoderm || anatomical group || whole organism || neuroectoderm || CaP motoneuron || neuron neural crest derived
Zebrafish Anatomy (ZA)	electrically responsive cell	1	1.216	--	INHERITED FROM: CaP motoneuron || primary motor neuron || primary neuron
Zebrafish Anatomy (ZA)	nervous system	0.2817	0.7079	Least Informative	INHERITED FROM: primary motor neuron || primary neuron || CaP motoneuron
Zebrafish Anatomy (ZA)	cell	0.4357	0.6388	Least Informative	INHERITED FROM: CaP motoneuron || primary neuron || neuron neural crest derived || primary motor neuron
Zebrafish Anatomy (ZA)	electrically active cell	0.04379	1.17	Moderately Informative	INHERITED FROM: primary neuron || primary motor neuron || CaP motoneuron
Zebrafish Anatomy (ZA)	portion of tissue	0.3224	0.7637	Moderately Informative	INHERITED FROM: ectoderm || primary motor neuron || primary neuron || CaP motoneuron || neuroectoderm
Zebrafish Anatomy (ZA)	neuron	0.0123	1.568	Informative	INHERITED FROM: primary motor neuron || primary neuron || CaP motoneuron
Zebrafish Anatomy (ZA)	ectoderm	0.0008857	1.994	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	motor neuron	0.001499	1.994	Highly Informative	INHERITED FROM: primary motor neuron || CaP motoneuron

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	cranial placode	0.000000007338	1.719	--	DIRECT
Xenopus ANatomical entity (XAN)	neural crest	0.00000003032	1.689	--	DIRECT
Xenopus ANatomical entity (XAN)	otic placode	0.000000695	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	branchial arch	0.0001651	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical line	0.000326	2.166	--	DIRECT
Xenopus ANatomical entity (XAN)	neural plate	0.0005213	1.635	--	DIRECT
Xenopus ANatomical entity (XAN)	circumblastoporal collar	0.02063	2.02	--	INHERITED FROM: involuted dorsal mesoderm
Xenopus ANatomical entity (XAN)	pharyngeal arch	0.02751	1.689	--	INHERITED FROM: branchial arch
Xenopus ANatomical entity (XAN)	primary germ layer	0.0692	0.6748	--	INHERITED FROM: cranial placode || neural plate || midbrain-hindbrain boundary || neural crest || neuroectoderm || cranial neural crest || otic placode
Xenopus ANatomical entity (XAN)	central nervous system	0.1931	0.5841	--	INHERITED FROM: midbrain-hindbrain boundary || presumptive midbrain-hindbrain boundary
Xenopus ANatomical entity (XAN)	head region	0.4744	0.4759	--	INHERITED FROM: periocular region || midbrain-hindbrain boundary || branchial arch
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: presumptive midbrain-hindbrain boundary || midbrain-hindbrain boundary || otic placode || sensory system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: neural plate || midbrain-hindbrain boundary || involuted dorsal mesoderm || cranial neural crest || anatomical group || branchial arch || presumptive midbrain-hindbrain boundary || cavitated compound organ || multicellular anatomical structure || periocular region || compound organ || anatomical region || cranial placode || sensory system || otic placode || multi-tissue structure || neuroectoderm || organism subdivision || embryonic structure || neural crest
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	embryo	0.1039	0.5979	Least Informative	INHERITED FROM: embryonic structure || presumptive midbrain-hindbrain boundary || neural plate || cranial placode || otic placode || cranial neural crest || neuroectoderm || involuted dorsal mesoderm || neural crest || midbrain-hindbrain boundary
Xenopus ANatomical entity (XAN)	nervous system	0.3462	0.5619	Least Informative	INHERITED FROM: midbrain-hindbrain boundary || sensory system || otic placode || presumptive midbrain-hindbrain boundary
Xenopus ANatomical entity (XAN)	head	0.428	0.4777	Least Informative	INHERITED FROM: branchial arch || midbrain-hindbrain boundary
Xenopus ANatomical entity (XAN)	tissue	0.5392	0.4672	Least Informative	INHERITED FROM: neural plate || cranial placode || involuted dorsal mesoderm || midbrain-hindbrain boundary || cranial neural crest || otic placode || neuroectoderm || neural crest
Xenopus ANatomical entity (XAN)	sensory system	0.000002344	1.158	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	multi-tissue structure	0.0003376	1.066	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	embryonic structure	0.0003888	1.149	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	ectoderm	0.006112	0.9357	Moderately Informative	INHERITED FROM: neuroectoderm || otic placode || cranial neural crest || midbrain-hindbrain boundary || neural plate || cranial placode || neural crest
Xenopus ANatomical entity (XAN)	brain	0.3175	0.7859	Moderately Informative	INHERITED FROM: midbrain-hindbrain boundary
Xenopus ANatomical entity (XAN)	neuroectoderm	0.000004046	1.374	Informative	DIRECT
Xenopus ANatomical entity (XAN)	pharyngeal region	0.05601	1.467	Informative	INHERITED FROM: branchial arch
Xenopus ANatomical entity (XAN)	vestibuloauditory system	0.5541	1.543	Informative	INHERITED FROM: otic placode
Xenopus ANatomical entity (XAN)	cranial neural crest	0.000002865	1.824	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	periocular region	0.000005706	2.02	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	presumptive midbrain-hindbrain boundary	0.0001625	2.166	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	involuted dorsal mesoderm	0.0002047	2.02	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	midbrain-hindbrain boundary	0.0009444	2.166	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	neurogenic placode	1	1.824	Highly Informative	INHERITED FROM: otic placode
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.7021	--	DIRECT
Enzyme Commission (EC)	Protein-tyrosine kinases	0	1.767	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Receptor protein-tyrosine kinase	0	2.084	Highly Informative	DIRECT

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