Myotubularin-like phosphatases family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: (Phosphotyrosine protein) phosphatases II [ 52798]
• Superfamily: (Phosphotyrosine protein) phosphatases II [ 52799] (5)
• Family: Myotubularin-like phosphatases [ 102422]

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Family statistics

	Genomes (459)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,203	6,649	2
Proteins	2,175	6,586	2

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Phosphatidylinositol-3-phosphatase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.0000000001407	0.01852	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.5107	Least Informative	DIRECT
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0	0.9703	Moderately Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0	0.4712	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the foot	0	1.082	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0	0.6771	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the curvature of the vertebral column	0	1.258	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0	0.6915	--	DIRECT
Phenotypic Abnormality (PA)	Decreased nerve conduction velocity	0.00000337	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal nerve conduction velocity	0.00000381	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of peripheral nerve conduction	0.000004536	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Sensory impairment	0.00007108	1.86	--	DIRECT
Phenotypic Abnormality (PA)	Reduced tendon reflexes	0.001245	1.985	--	INHERITED FROM: Areflexia
Phenotypic Abnormality (PA)	Abnormality of peripheral nerves	0.002243	2.462	--	INHERITED FROM: Abnormality of peripheral nerve conduction || Decreased nerve conduction velocity || Abnormal nerve conduction velocity
Phenotypic Abnormality (PA)	Abnormal myelination	0.005109	1.763	--	INHERITED FROM: Abnormal peripheral myelination
Phenotypic Abnormality (PA)	Abnormality of the musculature	0	0.5433	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	0.513	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.3869	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0	0.4756	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of limbs	0	0.6429	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal peripheral nervous system morphology	0	1.232	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the vertebral column	0	1.031	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0	0.9309	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal skeletal muscle morphology	0	0.9061	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of movement	0.2081	1.064	Moderately Informative	INHERITED FROM: Areflexia
Phenotypic Abnormality (PA)	Muscle weakness	0	1.316	Informative	DIRECT
Phenotypic Abnormality (PA)	Scoliosis	0	1.383	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal nervous system electrophysiology	0.004842	1.462	Informative	INHERITED FROM: Abnormal nerve conduction velocity || Abnormality of peripheral nervous system electrophysiology || Abnormality of peripheral nerve conduction || Decreased nerve conduction velocity
Phenotypic Abnormality (PA)	Abnormal reflex	0.01536	1.508	Informative	INHERITED FROM: Areflexia
Phenotypic Abnormality (PA)	Peripheral neuropathy	0.3375	1.421	Informative	INHERITED FROM: Distal sensory impairment || Sensory impairment
Phenotypic Abnormality (PA)	Distal sensory impairment	0.000006292	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of peripheral nervous system electrophysiology	0.000006977	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Areflexia	0.00009422	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal peripheral myelination	0.0006221	2.161	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	cell corpse number variant	0	1.306	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	apoptosis variant	0	1.125	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	sterile progeny	0	0.6547	--	DIRECT
Worm Phenotype (WP)	programmed cell death variant	0	1.087	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	coelomic system physiology variant	0.000003195	1.814	--	DIRECT
Worm Phenotype (WP)	Q neuroblast lineage migration variant	0.000005042	1.689	--	DIRECT
Worm Phenotype (WP)	neuron migration variant	0.000008026	1.623	--	DIRECT
Worm Phenotype (WP)	endocytic transport variant	0.000009614	1.354	--	DIRECT
Worm Phenotype (WP)	coelomocyte physiology variant	0.0003122	1.924	--	DIRECT
Worm Phenotype (WP)	vesicle trafficking variant	0.003509	1.354	--	INHERITED FROM: endocytic transport variant || coelomocyte endocytosis defective
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: cell corpse number variant || neuron migration variant || hermaphrodite fertility variant || developmental growth variant || retarded heterochronic variations || larval lethal || reproductive system physiology variant || endocytic transport variant || organism homeostasis metabolism variant || apoptosis variant || lethal || larval development variant || sterile progeny || organism physiology variant || progeny variant || slow growth || development variant || developmental timing variant || coelomocyte endocytosis defective || coelomocyte physiology variant || cell physiology variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || cell death variant || embryonic development variant || embryonic lethal || Q neuroblast lineage migration variant || larval growth variant || general pace of development variant || fertility variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || coelomic system physiology variant || organism development variant || programmed cell death variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile || sterile progeny
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT
Worm Phenotype (WP)	larval lethal	0	0.5727	Least Informative	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	progeny variant	0	0.6514	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0	0.5955	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0.001895	0.6752	Least Informative	INHERITED FROM: neuron migration variant || Q neuroblast lineage migration variant
Worm Phenotype (WP)	cell death variant	0	1.061	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell migration variant	0.009737	1.407	Informative	INHERITED FROM: neuron migration variant || Q neuroblast lineage migration variant
Worm Phenotype (WP)	endocytic transport defect	1	1.407	Informative	INHERITED FROM: coelomocyte endocytosis defective
Worm Phenotype (WP)	coelomocyte endocytosis defective	0.000002824	2.07	Highly Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || organism

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	musculature system	0	1.325	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	muscle	0	1.43	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: skeletal muscle || cell || anatomical system || multi-tissue structure || trunk || anatomical group || portion of tissue || whole organism || muscle cell || musculature system || electrically active cell || muscle || organism subdivision
Zebrafish Anatomy (ZA)	electrically responsive cell	1	1.216	--	INHERITED FROM: muscle cell
Zebrafish Anatomy (ZA)	organism subdivision	0	0.614	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	multi-tissue structure	0	0.5848	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	cell	0	0.6388	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	portion of tissue	0	0.7637	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	electrically active cell	0	1.17	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	trunk	0	1.568	Informative	DIRECT
Zebrafish Anatomy (ZA)	skeletal muscle	0	1.626	Informative	DIRECT
Zebrafish Anatomy (ZA)	muscle cell	0	1.471	Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || anatomical region || organism subdivision
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Phosphatidylinositol-3-phosphatase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-3,5-bisphosphate 3-phosphatase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0	1.338	Informative	DIRECT

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