KA1-like superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: TBP-like [ 55944] (11)
• Superfamily: KA1-like [ 103243] (2)
• Families:
  • Kinase associated domain 1, KA1 [ 103244]
  • Ssp2 C-terminal domain-like [ 160723] (3)

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Superfamily statistics

	Genomes (478)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,007	5,886	5
Proteins	2,004	5,873	5

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Functional annotation

• General category: Metabolism
• Detailed category: Other enzymes

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0	1.145	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2175	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	[Tau protein] kinase	0.000000000001517	2.56	--	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	0.8971	Moderately Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal energy homeostasis	0.00000002585	1.906	--	DIRECT
Mammalian Phenotype (MP)	decreased circulating insulin level	0.00001336	2.508	--	DIRECT
Mammalian Phenotype (MP)	decreased susceptibility to diet-induced obesity	0.00001925	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating hormone level	0.00003309	1.128	--	DIRECT
Mammalian Phenotype (MP)	decreased circulating glucose level	0.00006933	1.906	--	DIRECT
Mammalian Phenotype (MP)	abnormal body weight	0.002659	1.186	--	INHERITED FROM: abnormal susceptibility to weight gain || decreased susceptibility to diet-induced obesity
Mammalian Phenotype (MP)	abnormal body size	0.007519	1.076	--	INHERITED FROM: abnormal susceptibility to weight gain || decreased susceptibility to diet-induced obesity
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.01034	0.7085	--	INHERITED FROM: decreased circulating glucose level || abnormal circulating hormone level || decreased circulating insulin level
Mammalian Phenotype (MP)	abnormal circulating glucose level	0.01042	1.73	--	INHERITED FROM: decreased circulating glucose level
Mammalian Phenotype (MP)	abnormal circulating insulin level	0.02716	1.906	--	INHERITED FROM: decreased circulating insulin level
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.06593	0.3617	--	INHERITED FROM: abnormal circulating hormone level || abnormal energy homeostasis || abnormal hormone level || decreased circulating insulin level || decreased susceptibility to diet-induced obesity || abnormal energy expenditure || decreased circulating glucose level
Mammalian Phenotype (MP)	decreased susceptibility to weight gain	0.4936	2.207	--	INHERITED FROM: decreased susceptibility to diet-induced obesity
Mammalian Phenotype (MP)	increased energy expenditure	0.6197	2.207	--	INHERITED FROM: decreased susceptibility to diet-induced obesity
Mammalian Phenotype (MP)	growth/size/body region phenotype	0.03843	0.7017	Least Informative	INHERITED FROM: decreased susceptibility to diet-induced obesity || abnormal susceptibility to weight gain
Mammalian Phenotype (MP)	abnormal homeostasis	0.0391	0.495	Least Informative	INHERITED FROM: abnormal circulating hormone level || abnormal hormone level || abnormal energy homeostasis || decreased circulating insulin level || abnormal energy expenditure || decreased susceptibility to diet-induced obesity || decreased circulating glucose level
Mammalian Phenotype (MP)	abnormal hormone level	0.00006233	1.076	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal postnatal growth/weight/body size	0.01288	0.9397	Moderately Informative	INHERITED FROM: decreased susceptibility to diet-induced obesity || abnormal susceptibility to weight gain
Mammalian Phenotype (MP)	abnormal glucose homeostasis	0.01762	1.332	Informative	INHERITED FROM: decreased circulating insulin level || decreased circulating glucose level
Mammalian Phenotype (MP)	abnormal energy expenditure	0.0000000204	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal susceptibility to weight gain	0.00000002795	2.031	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.3347	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	excretory secretory system development variant	0.00000000001513	1.929	--	DIRECT
Worm Phenotype (WP)	cell number variant	0.000002783	1.327	--	DIRECT
Worm Phenotype (WP)	organ system development variant	0.0006291	0.8099	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0.1456	0.6038	--	INHERITED FROM: RNA expression variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.6117	0.1501	--	INHERITED FROM: RNA expression variant
Worm Phenotype (WP)	organism physiology variant	0.6253	0.1405	--	INHERITED FROM: RNA expression variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || organ system development variant || RNA expression variant || lethal || extra excretory cells || excretory secretory system development variant || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || cell number variant || fertility variant || cell number increased || postembryonic development variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	excretory system development variant	1	2.009	--	INHERITED FROM: extra excretory cells
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism metabolism processing variant	0.2195	0.4572	Least Informative	INHERITED FROM: RNA expression variant
Worm Phenotype (WP)	cell number increased	0.0000007565	1.477	Informative	DIRECT
Worm Phenotype (WP)	RNA expression variant	0.0001365	1.407	Informative	DIRECT
Worm Phenotype (WP)	extra excretory cells	0.000000000003605	2.009	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.2018	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1389	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.4182	Least Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.05522	--	DIRECT
Fly Phenotype (FP)	increased mortality during development	0	0.6799	--	DIRECT
Fly Phenotype (FP)	increased mortality	0	0.5628	Least Informative	DIRECT
Fly Phenotype (FP)	lethal	0	0.798	Moderately Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.5108	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.4287	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0	0.5909	--	DIRECT
Xenopus ANatomical entity (XAN)	male genitalia	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1442	--	DIRECT
Xenopus ANatomical entity (XAN)	male organism	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1871	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.24	--	DIRECT
Xenopus ANatomical entity (XAN)	gonad	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.193	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.3094	--	INHERITED FROM: testis || urogenital system || genital system || male genitalia
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: urogenital system || head region || genital system || anatomical group || testis || cavitated compound organ || multicellular anatomical structure || gonad || compound organ || trunk || tissue || anatomical region || male genitalia || trunk region || male organism || organism subdivision || head
Xenopus ANatomical entity (XAN)	urogenital system	0	0.5011	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.5108	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.4308	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.5011	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.3033	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	testis	0	0.8318	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical entity in vitro	0	1.314	Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0.3035	--	DIRECT
Enzyme Commission (EC)	[Acetyl-CoA carboxylase] kinase	0	2.952	--	DIRECT
Enzyme Commission (EC)	[Hydroxymethylglutaryl-CoA reductase (NADPH)] kinase	0	2.952	--	DIRECT
Enzyme Commission (EC)	[Tau protein] kinase	0.000000000002083	2.952	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.5453	Least Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.181	Moderately Informative	DIRECT
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0	1.42	Informative	DIRECT

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