Kinase associated domain 1, KA1 family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: TBP-like [ 55944] (11)
• Superfamily: KA1-like [ 103243] (2)
• Family: Kinase associated domain 1, KA1 [ 103244]

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Family statistics

	Genomes (130)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	407	1,532	2
Proteins	407	1,530	2

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2728	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	[Tau protein] kinase	0.00000002027	2.44	--	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.042	Moderately Informative	DIRECT
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0	1.279	Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	decreased susceptibility to diet-induced obesity	0.0000008021	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal brown adipose tissue morphology	0.000001351	2.603	--	DIRECT
Mammalian Phenotype (MP)	decreased susceptibility to weight gain	0.000001677	2.302	--	DIRECT
Mammalian Phenotype (MP)	increased energy expenditure	0.000002057	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal energy homeostasis	0.00001157	1.904	--	DIRECT
Mammalian Phenotype (MP)	decreased circulating insulin level	0.00002949	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating insulin level	0.0001376	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating hormone level	0.001061	1.241	--	INHERITED FROM: abnormal circulating insulin level || decreased circulating insulin level
Mammalian Phenotype (MP)	abnormal adipose tissue morphology	0.001114	1.223	--	INHERITED FROM: abnormal brown adipose tissue morphology || abnormal adipose tissue amount
Mammalian Phenotype (MP)	abnormal glucose homeostasis	0.00235	1.261	--	INHERITED FROM: decreased circulating insulin level || abnormal circulating insulin level || abnormal circulating glucose level || decreased circulating glucose level
Mammalian Phenotype (MP)	abnormal body weight	0.01746	1.156	--	INHERITED FROM: abnormal susceptibility to weight gain || decreased susceptibility to weight gain || decreased susceptibility to diet-induced obesity
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.04184	0.6893	--	INHERITED FROM: decreased circulating glucose level || abnormal circulating insulin level || decreased circulating insulin level || abnormal circulating glucose level
Mammalian Phenotype (MP)	abnormal postnatal growth/weight/body size	0.04894	0.8956	--	INHERITED FROM: decreased susceptibility to weight gain || decreased susceptibility to diet-induced obesity || abnormal susceptibility to weight gain
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.1477	0.3626	--	INHERITED FROM: abnormal circulating glucose level || increased energy expenditure || abnormal energy homeostasis || decreased circulating insulin level || decreased susceptibility to diet-induced obesity || abnormal energy expenditure || abnormal circulating insulin level || decreased circulating glucose level
Mammalian Phenotype (MP)	growth/size/body region phenotype	0.1009	0.6254	Least Informative	INHERITED FROM: decreased susceptibility to diet-induced obesity || decreased susceptibility to weight gain || abnormal susceptibility to weight gain
Mammalian Phenotype (MP)	abnormal homeostasis	0.1033	0.4926	Least Informative	INHERITED FROM: increased energy expenditure || abnormal circulating glucose level || abnormal energy homeostasis || decreased circulating insulin level || abnormal energy expenditure || decreased susceptibility to diet-induced obesity || decreased circulating glucose level || abnormal circulating insulin level
Mammalian Phenotype (MP)	adipose tissue phenotype	0.0012	1.205	Moderately Informative	INHERITED FROM: abnormal brown adipose tissue morphology || abnormal adipose tissue amount
Mammalian Phenotype (MP)	abnormal hormone level	0.001585	1.141	Moderately Informative	INHERITED FROM: abnormal circulating insulin level || decreased circulating insulin level
Mammalian Phenotype (MP)	abnormal body size	0.0347	1.001	Moderately Informative	INHERITED FROM: decreased susceptibility to weight gain || abnormal susceptibility to weight gain || decreased susceptibility to diet-induced obesity
Mammalian Phenotype (MP)	abnormal adipose tissue amount	0.0004397	1.489	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal circulating glucose level	0.0005899	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal energy expenditure	0.00001024	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal susceptibility to weight gain	0.00001203	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased circulating glucose level	0.0001077	2.001	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || postembryonic development variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0	0.5751	--	DIRECT
Xenopus ANatomical entity (XAN)	male genitalia	0	0.7647	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	male organism	0	0.7647	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	gonad	0	0.7579	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: testis || urogenital system || genital system || male genitalia
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || head region || genital system || anatomical group || testis || cavitated compound organ || multicellular anatomical structure || gonad || compound organ || trunk || tissue || anatomical region || male genitalia || trunk region || male organism || organism subdivision || head
Xenopus ANatomical entity (XAN)	urogenital system	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	testis	0	0.7647	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical entity in vitro	0	1.347	Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.7021	--	DIRECT
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0	1.639	--	DIRECT
Enzyme Commission (EC)	[Tau protein] kinase	0.00000001455	2.929	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.437	Informative	DIRECT

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