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Home > SCOP hierarchy > 2-methylcitrate dehydratase PrpD superfamily

2-methylcitrate dehydratase PrpD superfamily

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:	2-methylcitrate dehydratase PrpD [ 103377]
Superfamily:	2-methylcitrate dehydratase PrpD [ 103378]
Families:	2-methylcitrate dehydratase PrpD [ 103379]

Superfamily statistics

	Genomes (1,125)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,866	16,016	1
Proteins	1,855	15,987	1

Functional annotation

General category	Metabolism
Detailed category	Redox

Document: Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Lyases	0	Least Informative	Direct
Enzyme Commission (EC)	Hydro-lyases	0	Moderately Informative	Direct

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Lyases	0	Least Informative	Direct
Enzyme Commission (EC)	Carbon-oxygen lyases	0.007637	Moderately Informative	Inherited
Enzyme Commission (EC)	Carbon-carbon lyases	0.623	Moderately Informative	Inherited
Enzyme Commission (EC)	Carboxy-lyases	0.00002931	Informative	Direct

Document: EC annotation of SCOP domains

InterPro annotation

Cross references IPR005656 SSF103378 Protein matches

Abstract
This entry represents proteins from the MmgE/PrpD family, which includes 2-methylcitrate dehydratase (PrpD). PrpD is required for propionate catabolism, catalysing the third step of the 2-methylcitric acid cycle [ PubMed 11782506]. This enzyme consists of two domains: a large domain with an all-helical fold and a smaller domain that folds into an alpha+beta domain.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs

Cross references

PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a 2-methylcitrate dehydratase PrpD domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the 2-methylcitrate dehydratase PrpD superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Enzyme Commission (EC) · Internal database links ]

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2-methylcitrate dehydratase PrpD superfamily