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  Home > SCOP hierarchy > BAR/IMD domain-like superfamily


BAR/IMD domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   BAR/IMD domain-like [ 116747]
Superfamily:   BAR/IMD domain-like [ 103657] (4)
Families:   BAR domain [ 103658] (3)
  Arfaptin, Rac-binding fragment [ 64599]
  IMD domain [ 140703]
  FCH domain [ 158645] (2)

Superfamily statistics
Genomes (547) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 14,083 43,150 12
Proteins 13,876 42,731 12

 Functional annotation
General category General
Detailed category Protein interaction

Document: Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.5735Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.6777Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.9418Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.2519Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.4257Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.4517Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.5578Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.5624Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.6709Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.02139InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.1185InformativeInherited
Mammalian Phenotype (MP)abnormal erythroid lineage cell morphology0.2269InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.2827InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.2893InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic vesicle recycling0.00000007855Highly InformativeDirect
Mammalian Phenotype (MP)decreased excitatory postsynaptic current amplitude0.00001381Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synapse morphology0.00386Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hematocrit0.01212Highly InformativeInherited
Mammalian Phenotype (MP)abnormal gametes0.5273Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.005488Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.006707Least InformativeInherited
Worm Phenotype (WP)cell development variant0.01428Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.0002176Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.004465Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.2059Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.2994Moderately InformativeInherited
Worm Phenotype (WP)accumulated germline cell corpses0.00001929InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.009045InformativeInherited
Worm Phenotype (WP)neuron migration variant0.08608InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.08614InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.4653InformativeInherited
Worm Phenotype (WP)anterior neuron migration defective0.00001332Highly InformativeDirect
Worm Phenotype (WP)gut granule development variant0.0002099Highly InformativeDirect
Worm Phenotype (WP)dye filling defect0.0006334Highly InformativeDirect
Worm Phenotype (WP)cleavage furrow defective0.0007771Highly InformativeDirect
Worm Phenotype (WP)cytokinesis defective early emb0.005289Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0.1463Least InformativeInherited
Fly Anatomy (FA)nervous system0.374Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.4405Least InformativeInherited
Fly Anatomy (FA)adult0.445Least InformativeInherited
Fly Anatomy (FA)larva0.6991Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.09115Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2087Moderately InformativeInherited
Fly Anatomy (FA)cell component0.007344InformativeInherited
Fly Anatomy (FA)bouton0.00003403Highly InformativeDirect
Fly Anatomy (FA)neuromuscular junction0.0001066Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.373Least InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.2506Moderately InformativeInherited
Zebrafish Anatomy (ZA)olfactory system0.0001958Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BAR/IMD domain-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the BAR/IMD domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.