SUPERFAMILY 1.75 HMM library and genome assignments server

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1oqa A: PDB entry domain

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   BRCT domain [ 52112]
Superfamily:   BRCT domain [ 52113] (5)
Family:   BRCT domain [ 63955]
Protein:   Breast cancer associated protein, BRCA1 [63956]
   
PDB Entry Domain:   1oqa A: [ 104021]
  SUPERFAMILY domain annotation for 1oqaa
  PDB structure summary for 1oqa


InterPro annotation
Cross references IPR001357 SSF52113 Protein matches
Abstract

The BRCT domain (after the C_terminal domain of a breast cancer susceptibility protein) is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage [PubMed9034168], for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain [PubMed14576433].

A chitin biosynthesis protein from yeast also seems to belong to this group.


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a BRCT domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Internal database links ]