SUPERFAMILY 1.75 HMM library and genome assignments server

SUPERFAMILY 2 can be accessed from Please contact us if you experience any problems.

KRAB domain (Kruppel-associated box) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   KRAB domain (Kruppel-associated box) [ 109639]
Superfamily:   KRAB domain (Kruppel-associated box) [ 109640]
Family:   KRAB domain (Kruppel-associated box) [ 109641]

Family statistics
Genomes (1) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 7 8 1
Proteins 7 8 1

Human Phenotype (HP)

show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0.5525Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.8112Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system morphology0.08612Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.1745Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.02603InformativeInherited
Phenotypic Abnormality (PA)Seizures0.2264InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the small intestine0.0008866Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized-onset seizure0.001408Highly InformativeInherited

Document: HP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Xenopus Anatomy (XA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a KRAB domain (Kruppel-associated box) domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Xenopus Anatomy (XA) · Internal database links ]