H-NOX domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Ligand-binding domain in the NO signalling and Golgi transport [ 111125]
• Superfamily: Ligand-binding domain in the NO signalling and Golgi transport [ 111126] (3)
• Family: H-NOX domain [ 111127]

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Family statistics

	Genomes (52)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	53	255	2
Proteins	53	255	2

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Phosphorus-oxygen lyases	0	1.838	--	DIRECT
Enzyme Commission (EC)	Phosphorus-oxygen lyases	1	1.838	--	INHERITED FROM: Guanylate cyclase
Enzyme Commission (EC)	Lyases	0	0.4956	Least Informative	DIRECT
Enzyme Commission (EC)	Guanylate cyclase	0	2.139	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	induced pharyngeal pumping variant	0.000000001833	2.292	--	DIRECT
Worm Phenotype (WP)	carbon dioxide response variant	0.00000005398	1.924	--	DIRECT
Worm Phenotype (WP)	anesthetic response variant	0.0000001668	1.769	--	DIRECT
Worm Phenotype (WP)	eating variant	0.000001759	1.769	--	DIRECT
Worm Phenotype (WP)	feeding behavior variant	0.00006838	1.25	--	DIRECT
Worm Phenotype (WP)	drug response variant	0.0002078	1.135	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.01835	0.6859	--	INHERITED FROM: eating variant || pharyngeal pumping rate variant || feeding behavior variant || induced pharyngeal pumping variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.7563	0.1444	--	INHERITED FROM: drug response variant || carbon dioxide response variant || anesthetic response variant || carbon dioxide avoidance variant
Worm Phenotype (WP)	organism physiology variant	0.7688	0.1342	--	INHERITED FROM: drug response variant || carbon dioxide response variant || anesthetic response variant || carbon dioxide avoidance variant
Worm Phenotype (WP)	pharyngeal pumping variant	1	1.99	--	INHERITED FROM: pharyngeal pumping rate variant || induced pharyngeal pumping variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || carbon dioxide avoidance variant || reproductive system physiology variant || lethal || eating variant || carbon dioxide response variant || induced pharyngeal pumping variant || development variant || pharyngeal pumping rate variant || hermaphrodite sterile || drug response variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || anesthetic response variant || feeding behavior variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism environmental stimulus response variant	0.01285	0.6614	Least Informative	INHERITED FROM: drug response variant || anesthetic response variant || carbon dioxide response variant || carbon dioxide avoidance variant
Worm Phenotype (WP)	organism behavior variant	0.01807	0.6859	Least Informative	INHERITED FROM: eating variant || induced pharyngeal pumping variant || pharyngeal pumping rate variant || feeding behavior variant
Worm Phenotype (WP)	chemical response variant	0.001493	0.9053	Moderately Informative	INHERITED FROM: anesthetic response variant || drug response variant || carbon dioxide avoidance variant || carbon dioxide response variant
Worm Phenotype (WP)	carbon dioxide avoidance variant	0.00000004897	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	pharyngeal pumping rate variant	0.0000005588	1.99	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	stress response defective	0	1.908	Highly Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Phosphorus-oxygen lyases	0	1.951	--	DIRECT
Enzyme Commission (EC)	Guanylate cyclase	0	2.628	--	DIRECT
Enzyme Commission (EC)	Lyases	0	0.8775	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphorus-oxygen lyases	1	1.951	Highly Informative	INHERITED FROM: Guanylate cyclase

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