Kelch motif superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: 6-bladed beta-propeller [ 50938] (11)
• Superfamily: Kelch motif [ 117281]
• Families: Kelch motif [ 117282]

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Superfamily statistics

	Genomes (957)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	20,144	62,485	4
Proteins	17,777	54,891	4

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Functional annotation

• General category: General
• Detailed category: General

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	N-acetylneuraminate epimerase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.8239	0.04271	--	INHERITED FROM: Phosphoric monoester hydrolases || Phosphoprotein phosphatase
Enzyme Commission (EC)	Isomerases	0	0.5914	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.007019	0.4665	Least Informative	INHERITED FROM: Phosphoric monoester hydrolases || Phosphoprotein phosphatase
Enzyme Commission (EC)	Racemases and epimerases	0	1.238	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0.000004386	0.9165	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on carbohydrates and derivatives	0	1.519	Informative	DIRECT
Enzyme Commission (EC)	Phosphoprotein phosphatase	0.0000000001653	1.56	Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Nemaline bodies	0.00001628	2.106	--	DIRECT
Phenotypic Abnormality (PA)	Fetal akinesia sequence	0.00007712	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Muscle fiber cytoplasmatic inclusion bodies	0.00007712	2.106	--	DIRECT
Phenotypic Abnormality (PA)	Type 1 muscle fiber predominance	0.0005627	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the seventh cranial nerve	0.0006805	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal delivery	0.0153	1.628	--	INHERITED FROM: Breech presentation
Phenotypic Abnormality (PA)	Abnormal peripheral nervous system morphology	0.04628	1.26	--	INHERITED FROM: Abnormality of the seventh cranial nerve
Phenotypic Abnormality (PA)	Prenatal movement abnormality	0.07532	1.804	--	INHERITED FROM: Fetal akinesia sequence
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.4051	0.2543	--	INHERITED FROM: Abnormality of the seventh cranial nerve
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.1654	0.5677	Least Informative	INHERITED FROM: Abnormality of the seventh cranial nerve
Phenotypic Abnormality (PA)	Abnormality of the musculature	0.2469	0.6004	Least Informative	INHERITED FROM: Muscle fiber inclusion bodies || Type 1 muscle fiber predominance || Nemaline bodies || Muscle fiber cytoplasmatic inclusion bodies
Phenotypic Abnormality (PA)	Abnormal skeletal muscle morphology	0.05598	0.9294	Moderately Informative	INHERITED FROM: Muscle fiber cytoplasmatic inclusion bodies || Muscle fiber inclusion bodies || Type 1 muscle fiber predominance || Nemaline bodies
Phenotypic Abnormality (PA)	Abnormal muscle fiber morphology	0.08292	1.628	Informative	INHERITED FROM: Muscle fiber cytoplasmatic inclusion bodies || Nemaline bodies || Type 1 muscle fiber predominance || Muscle fiber inclusion bodies
Phenotypic Abnormality (PA)	Abnormality of prenatal development or birth	0.09727	1.407	Informative	INHERITED FROM: Fetal akinesia sequence || Breech presentation
Phenotypic Abnormality (PA)	Breech presentation	0.00002069	1.929	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Muscle fiber inclusion bodies	0.0001359	1.929	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Decreased fetal movement	0.01907	1.804	Highly Informative	INHERITED FROM: Fetal akinesia sequence
Phenotypic Abnormality (PA)	Abnormal cranial nerve morphology	0.02887	2.106	Highly Informative	INHERITED FROM: Abnormality of the seventh cranial nerve

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.2018	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1389	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.4182	Least Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.07918	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.2279	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.009143	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || organism

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase	0	2.475	--	DIRECT
Enzyme Commission (EC)	methoxycarbonyltransferase	0	2.35	--	DIRECT
Enzyme Commission (EC)	N-acetylneuraminate epimerase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Methyltransferases	0.0001121	1.181	--	DIRECT
Enzyme Commission (EC)	Acyltransferases	0.001938	0.8446	--	INHERITED FROM: Transferring groups other than amino-acyl groups || methoxycarbonyltransferase
Enzyme Commission (EC)	Acting on ester bonds	0.02146	0.7559	--	INHERITED FROM: Protein-serine/threonine phosphatase || Phosphoric monoester hydrolases
Enzyme Commission (EC)	Transferases	1	0.3035	--	INHERITED FROM: Transferring groups other than amino-acyl groups || Methyltransferases || methoxycarbonyltransferase || tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase
Enzyme Commission (EC)	Hydrolases	0.9506	0.3541	Least Informative	INHERITED FROM: Phosphoric monoester hydrolases || Protein-serine/threonine phosphatase
Enzyme Commission (EC)	Isomerases	0	0.8446	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0.00001753	1.174	Moderately Informative	DIRECT
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0.0001557	1.119	Moderately Informative	DIRECT
Enzyme Commission (EC)	Transferring one-carbon groups	0.002045	1.054	Moderately Informative	INHERITED FROM: Methyltransferases || tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase
Enzyme Commission (EC)	Racemases and epimerases	0	1.447	Informative	DIRECT
Enzyme Commission (EC)	Acting on carbohydrates and derivatives	0	1.776	Highly Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine phosphatase	0.0000000006023	1.91	Highly Informative	DIRECT

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