Proton glutamate symport protein superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Membrane and cell surface proteins and peptides [ 56835] (58)
• Fold: Proton glutamate symport protein [ 118214]
• Superfamily: Proton glutamate symport protein [ 118215]
• Families: Proton glutamate symport protein [ 118216]

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Superfamily statistics

	Genomes (2,171)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	6,668	47,434	1
Proteins	6,588	47,201	1

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Functional annotation

• General category: Processes_IC
• Detailed category: Transport

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	cognitive disorder	0	1.092	--	DIRECT
Disease Ontology (DO)	psychotic disorder	0	1.292	--	DIRECT
Disease Ontology (DO)	demyelinating disease	0.0006778	1.417	--	DIRECT
Disease Ontology (DO)	central nervous system disease	0.03932	0.8526	--	INHERITED FROM: demyelinating disease || multiple sclerosis
Disease Ontology (DO)	disease of anatomical entity	0.3333	0.2157	--	INHERITED FROM: demyelinating disease || multiple sclerosis
Disease Ontology (DO)	nervous system disease	0.09793	0.6635	Least Informative	INHERITED FROM: demyelinating disease || multiple sclerosis
Disease Ontology (DO)	disease of mental health	0	1.009	Moderately Informative	DIRECT
Disease Ontology (DO)	neurodegenerative disease	0.01772	0.9909	Moderately Informative	INHERITED FROM: multiple sclerosis || demyelinating disease
Disease Ontology (DO)	schizophrenia	0	1.292	Informative	DIRECT
Disease Ontology (DO)	multiple sclerosis	0.0006506	1.468	Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2543	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.4022	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0	0.8268	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Neurodevelopmental abnormality	0	0.8502	Moderately Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	decreased neuron number	0.0001855	1.73	--	DIRECT
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.6248	0.627	--	INHERITED FROM: abnormal neuron number || decreased neuron number
Mammalian Phenotype (MP)	nervous system phenotype	0	0.5166	Least Informative	DIRECT
Mammalian Phenotype (MP)	abnormal nervous system physiology	0	0.8744	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal neuron morphology	0.009319	0.9516	Moderately Informative	INHERITED FROM: abnormal neuron number || decreased neuron number
Mammalian Phenotype (MP)	abnormal neuron number	0.0003488	1.605	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal nervous system electrophysiology	0	1.906	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.4022	--	DIRECT
Worm Phenotype (WP)	slow growth	0	0.5903	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.5373	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.3347	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.5677	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	progeny variant	0	0.7582	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1405	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1501	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.5677	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || retarded heterochronic variations || larval lethal || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || larval development variant || sterile progeny || organism physiology variant || progeny variant || slow growth || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || general pace of development variant || fertility variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile || sterile progeny
Worm Phenotype (WP)	general pace of development variant	0	0.5708	Least Informative	DIRECT
Worm Phenotype (WP)	larval lethal	0	0.6947	Least Informative	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.5373	Least Informative	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.5007	Least Informative	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.5677	Least Informative	DIRECT
Worm Phenotype (WP)	sterile progeny	0	0.7582	Moderately Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.5108	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1871	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.193	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: head region || multicellular anatomical structure || anatomical region || organism subdivision || head
Xenopus ANatomical entity (XAN)	head	0	0.5108	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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