SWIRM domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: DNA/RNA-binding 3-helical bundle [ 46688] (14)
• Superfamily: Homeodomain-like [ 46689] (19)
• Family: SWIRM domain [ 140222] (3)

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Family statistics

	Genomes (353)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	701	2,212	8
Proteins	701	2,211	8

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of body height	0	1.348	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.4454	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4538	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0	0.4712	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal skull morphology	0	0.8826	--	DIRECT
Phenotypic Abnormality (PA)	Global developmental delay	0	1.232	--	DIRECT
Phenotypic Abnormality (PA)	Growth abnormality	0	0.7903	--	DIRECT
Phenotypic Abnormality (PA)	Growth delay	0	1.316	--	DIRECT
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0	0.533	--	DIRECT
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the cerebrum	0	1.184	--	DIRECT
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving the skeleton	0	1.383	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0	0.6771	--	DIRECT
Phenotypic Abnormality (PA)	Aplasia/hypoplasia of the extremities	0	1.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0	0.6631	--	DIRECT
Phenotypic Abnormality (PA)	Neurodevelopmental abnormality	0	0.7381	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of forebrain morphology	0	0.9572	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the face	0	0.533	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the integument	0	0.6235	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	0.513	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.3869	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0	0.4756	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of limbs	0	0.6429	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skull size	0	1.101	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cerebrum	0	0.971	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia involving the central nervous system	0	1.047	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Neurodevelopmental delay	0	0.9853	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Short stature	0	1.421	Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.03924	0.6686	--	INHERITED FROM: abnormal bone marrow cell morphology/development
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.05785	0.5945	Least Informative	INHERITED FROM: abnormal bone marrow cell morphology/development
Mammalian Phenotype (MP)	abnormal bone marrow cell morphology/development	0.0003057	1.7	Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || retarded heterochronic variations || larval lethal || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || larval development variant || organism physiology variant || slow growth || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || general pace of development variant || fertility variant || shortened life span || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT
Worm Phenotype (WP)	larval lethal	0	0.5727	Least Informative	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	life span variant	0.003216	1.321	Informative	INHERITED FROM: shortened life span
Worm Phenotype (WP)	shortened life span	0.00002178	1.814	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.3202	Least Informative	DIRECT
Yeast Phenotype (YP)	morphology	0	1.143	Moderately Informative	DIRECT
Yeast Phenotype (YP)	chromosome/plasmid maintenance	0	1.444	Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	compound organ	0	0.4299	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism || compound organ || cavitated compound organ
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5123	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: multicellular anatomical structure
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	whole plant	0	0.3507	--	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3234	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.3446	--	DIRECT
Plant ANatomical entity (PAN)	pedicel	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.4476	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.4728	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence branch	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence axis	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.3837	--	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.4282	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.3304	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || calyx || inflorescence axis || flower || collective plant structure || plant embryo || leaf || phyllome || multi-tissue plant structure || guard cell || reproductive shoot system || shoot apex || branch || collective leaf structure || inflorescence branch || shoot system || portion of plant tissue || stomatal complex || plant organ || stem || whole plant || epidermis || inflorescence || vascular leaf || sepal || epidermal cell || shoot epidermal cell || plant axis || collective phyllome structure || plant cell || seed || shoot epidermis || shoot axis || pedicel
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: inflorescence axis || calyx || flower || inflorescence || perianth || stem || leaf || phyllome || sepal || vascular leaf || reproductive shoot system || shoot apex || collective phyllome structure || guard cell || shoot epidermal cell || pedicel || stomatal complex || inflorescence branch || shoot axis || shoot system || collective leaf structure || branch || shoot epidermis
Plant ANatomical entity (PAN)	shoot apex	0	0.481	Least Informative	DIRECT
Plant ANatomical entity (PAN)	plant embryo	0	0.4978	Least Informative	DIRECT
Plant ANatomical entity (PAN)	seed	0	0.5189	Least Informative	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0	0.437	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sepal	0	0.4728	Least Informative	DIRECT
Plant ANatomical entity (PAN)	stem	0	0.4777	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence	0	0.4859	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.46	Least Informative	DIRECT
Plant ANatomical entity (PAN)	branch	0	0.5373	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || E expanded cotyledon stage || F mature embryo stage || D bilateral stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: E expanded cotyledon stage || sporophyte vegetative stage || C globular stage || D bilateral stage || F mature embryo stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.2861	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.3205	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3087	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.301	Least Informative	DIRECT

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