CalX-like superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Immunoglobulin-like beta-sandwich [ 48725] (28)
• Superfamily: CalX-like [ 141072]
• Families: CalX-beta domain [ 141073]

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Superfamily statistics

	Genomes (479)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	7,641	32,196	3
Proteins	2,014	12,754	3

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Functional annotation

• General category: Other
• Detailed category: Unknown function

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.1924	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.472	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the mouth	0	0.8383	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the face	0	0.5614	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2543	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0	0.4621	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the foot	0	1.106	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal appendicular skeleton morphology	0	0.8625	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal oral morphology	0	0.8625	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of limb bone	0	0.9441	--	DIRECT
Phenotypic Abnormality (PA)	Cryptophthalmos	0.0000000009832	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Midline defect of the nose	0.00000003172	2.106	--	DIRECT
Phenotypic Abnormality (PA)	Anal stenosis	0.0000007627	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Anophthalmia	0.000002295	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Omphalocele	0.00000926	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the eyelid	0.00005945	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal nasolacrimal system morphology	0.000126	2.106	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the anus	0.0002609	2.106	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of globe size	0.002935	1.929	--	INHERITED FROM: Microphthalmia || Anophthalmia
Phenotypic Abnormality (PA)	Hernia of the abdominal wall	0.003775	2.106	--	INHERITED FROM: Omphalocele
Phenotypic Abnormality (PA)	Abdominal wall defect	0.003849	2.106	--	INHERITED FROM: Omphalocele
Phenotypic Abnormality (PA)	Morphological abnormality of the gastrointestinal tract	0.007713	1.293	--	INHERITED FROM: Anal stenosis || Abnormality of the anus || Ectopic anus
Phenotypic Abnormality (PA)	Abnormality of digestive system morphology	0.007713	1.293	--	INHERITED FROM: Anal stenosis || Abnormality of the anus || Ectopic anus
Phenotypic Abnormality (PA)	Abnormality of female internal genitalia	0.009349	1.26	--	INHERITED FROM: Abnormal vagina morphology
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia affecting the eye	0.01081	1.804	--	INHERITED FROM: Anophthalmia || Microphthalmia
Phenotypic Abnormality (PA)	Abnormality of the ocular adnexa	0.01461	1.176	--	INHERITED FROM: Cryptophthalmos || Aplasia/Hypoplasia of the eyelid || Abnormal lacrimal duct morphology || Abnormal nasolacrimal system morphology
Phenotypic Abnormality (PA)	Abnormality of the genital system	0.02021	0.8625	--	INHERITED FROM: Abnormal vagina morphology
Phenotypic Abnormality (PA)	Abnormal eye morphology	0.08028	0.8155	--	INHERITED FROM: Microphthalmia || Anophthalmia
Phenotypic Abnormality (PA)	Abnormality of the orbital region	0.1174	1.176	--	INHERITED FROM: Abnormal lacrimal duct morphology || Abnormal nasolacrimal system morphology || Aplasia/Hypoplasia of the eyelid || Cryptophthalmos
Phenotypic Abnormality (PA)	Abnormal internal genitalia	0.1467	1.23	--	INHERITED FROM: Abnormal vagina morphology
Phenotypic Abnormality (PA)	Abnormality of the female genitalia	0.1575	1.202	--	INHERITED FROM: Abnormal vagina morphology
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4771	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	0.472	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of limbs	0	0.6431	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0.1027	0.5432	Least Informative	INHERITED FROM: Abnormal vagina morphology
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.1412	0.5805	Least Informative	INHERITED FROM: Abnormality of the anus || Anal stenosis || Omphalocele || Ectopic anus
Phenotypic Abnormality (PA)	Abnormality of the eye	0.1789	0.6004	Least Informative	INHERITED FROM: Microphthalmia || Anophthalmia
Phenotypic Abnormality (PA)	Abnormality of limb bone morphology	0	0.9441	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0	0.9152	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of connective tissue	0	1.128	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal reproductive system morphology	0.01365	0.9594	Moderately Informative	INHERITED FROM: Abnormal vagina morphology
Phenotypic Abnormality (PA)	Abnormal ocular adnexa morphology	0.01381	1.176	Moderately Informative	INHERITED FROM: Cryptophthalmos || Aplasia/Hypoplasia of the eyelid || Abnormal nasolacrimal system morphology || Abnormal lacrimal duct morphology
Phenotypic Abnormality (PA)	Abnormality of the gastrointestinal tract	0.02226	1.026	Moderately Informative	INHERITED FROM: Ectopic anus || Anal stenosis || Abnormality of the anus
Phenotypic Abnormality (PA)	Abnormal eyelid morphology	0.007862	1.407	Informative	INHERITED FROM: Aplasia/Hypoplasia of the eyelid || Cryptophthalmos
Phenotypic Abnormality (PA)	Anorectal anomaly	0.02608	1.708	Informative	INHERITED FROM: Anal stenosis || Abnormality of the anus || Ectopic anus
Phenotypic Abnormality (PA)	Hernia	0.1768	1.708	Informative	INHERITED FROM: Omphalocele
Phenotypic Abnormality (PA)	Abnormality of the nose	0.4622	1.327	Informative	INHERITED FROM: Midline defect of the nose
Phenotypic Abnormality (PA)	Abnormal lacrimal duct morphology	0.0000004086	2.106	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Ectopic anus	0.000002545	2.106	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal vagina morphology	0.00003752	2.106	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Microphthalmia	0.000497	1.929	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the abdominal wall	0.01078	1.929	Highly Informative	INHERITED FROM: Omphalocele
Phenotypic Abnormality (PA)	Abnormal nasal morphology	0.03338	1.929	Highly Informative	INHERITED FROM: Midline defect of the nose

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	cryptophthalmos	0.000000000966	2.508	--	DIRECT
Mammalian Phenotype (MP)	absent eyelids	0.0000001115	2.508	--	DIRECT
Mammalian Phenotype (MP)	bleb	0.000005444	2.508	--	DIRECT
Mammalian Phenotype (MP)	absent kidney	0.00000912	2.508	--	DIRECT
Mammalian Phenotype (MP)	syndactyly	0.00007461	2.508	--	DIRECT
Mammalian Phenotype (MP)	polydactyly	0.0001047	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal autopod morphology	0.002666	1.73	--	INHERITED FROM: polydactyly || syndactyly
Mammalian Phenotype (MP)	vision/eye phenotype	0.005544	0.8744	--	INHERITED FROM: absent eyelids || microphthalmia || cryptophthalmos
Mammalian Phenotype (MP)	abnormal skin morphology	0.006203	1.229	--	INHERITED FROM: blistering || bleb || abnormal skin appearance
Mammalian Phenotype (MP)	abnormal eye size	0.006296	2.031	--	INHERITED FROM: microphthalmia
Mammalian Phenotype (MP)	renal/urinary system phenotype	0.01347	0.8951	--	INHERITED FROM: absent kidney
Mammalian Phenotype (MP)	limbs/digits/tail phenotype	0.03947	1.253	--	INHERITED FROM: polydactyly || syndactyly
Mammalian Phenotype (MP)	abnormal kidney morphology	0.8304	1.093	--	INHERITED FROM: absent kidney
Mammalian Phenotype (MP)	abnormal renal/urinary system morphology	0.005669	1.016	Moderately Informative	INHERITED FROM: absent kidney
Mammalian Phenotype (MP)	integument phenotype	0.05586	0.8451	Moderately Informative	INHERITED FROM: blistering || bleb || abnormal skin appearance
Mammalian Phenotype (MP)	abnormal eye morphology	0.8041	0.9168	Moderately Informative	INHERITED FROM: microphthalmia || cryptophthalmos || absent eyelids
Mammalian Phenotype (MP)	abnormal skin appearance	0.0006643	1.663	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal limb morphology	0.02137	1.429	Informative	INHERITED FROM: syndactyly || polydactyly
Mammalian Phenotype (MP)	microphthalmia	0.000362	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	blistering	0.0004597	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal digit morphology	0.001472	1.906	Highly Informative	INHERITED FROM: polydactyly || syndactyly
Mammalian Phenotype (MP)	abnormal eyelid morphology	0.01289	1.906	Highly Informative	INHERITED FROM: absent eyelids || cryptophthalmos

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.3347	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || postembryonic development variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.2245	--	DIRECT
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5472	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1889	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || multi-tissue structure || anatomical cluster || anatomical group || whole organism || organism subdivision || compound organ || cavitated compound organ
Zebrafish Anatomy (ZA)	compound organ	0	0.4571	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	organism subdivision	0	0.6264	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	multi-tissue structure	0	0.6005	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	anatomical cluster	0	0.883	Moderately Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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