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CalX-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   CalX-like [ 141072]
Families:   CalX-beta domain [ 141073]

Superfamily statistics
Genomes (479) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 7,641 32,196 3
Proteins 2,014 12,754 3

Functional annotation
General category Other
Detailed category Unknown function

Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the head0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1027Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1412Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.1789Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lower limb0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.01365Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.01381Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.02226Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eyelid morphology0.007862InformativeInherited
Phenotypic Abnormality (PA)Anorectal anomaly0.02608InformativeInherited
Phenotypic Abnormality (PA)Hernia0.1768InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.4622InformativeInherited
Phenotypic Abnormality (PA)Abnormal lacrimal duct morphology0.0000004086Highly InformativeDirect
Phenotypic Abnormality (PA)Ectopic anus0.000002545Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal vagina morphology0.00003752Highly InformativeDirect
Phenotypic Abnormality (PA)Microphthalmia0.000497Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdominal wall0.01078Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal nasal morphology0.03338Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.005669Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.05586Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.8041Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.0006643InformativeDirect
Mammalian Phenotype (MP)abnormal limb morphology0.02137InformativeInherited
Mammalian Phenotype (MP)microphthalmia0.000362Highly InformativeDirect
Mammalian Phenotype (MP)blistering0.0004597Highly InformativeDirect
Mammalian Phenotype (MP)abnormal digit morphology0.001472Highly InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.01289Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)anatomical cluster0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a CalX-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the CalX-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]