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  Home > SCOP hierarchy > E2F-DP heterodimerization region superfamily


E2F-DP heterodimerization region superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   E2F-DP heterodimerization region [ 144073]
Superfamily:   E2F-DP heterodimerization region [ 144074] (2)
Families:   DP dimerization segment [ 144075]
  E2F dimerization segment [ 144078]

 Superfamily statistics
Genomes (258) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,605 4,013 2
Proteins 1,591 3,964 2

 Functional annotation
General category Information
Detailed category Transcription

Document: Function annotation of SCOP domain superfamilies

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.01296Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.05621Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1731Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.0006627Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system morphology0.0009052Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.006426Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01321Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.02511Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.03158Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.04161Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.05363Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.0641Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.09941Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.3794Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.5367Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.8023Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal male reproductive gland morphology0.00006935InformativeDirect
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.00008778InformativeDirect
Mammalian Phenotype (MP)abnormal T cell differentiation0.0001829InformativeDirect
Mammalian Phenotype (MP)decreased cell proliferation0.0003413InformativeDirect
Mammalian Phenotype (MP)abnormal eye development0.000821InformativeDirect
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.001223InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.001545InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.004138InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.005158InformativeInherited
Mammalian Phenotype (MP)abnormal fertility/fecundity0.01235InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.3076InformativeInherited
Mammalian Phenotype (MP)abnormal retinal ganglion cell morphology0.00002284Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell cycle0.00003287Highly InformativeDirect
Mammalian Phenotype (MP)lethality throughout fetal growth and development, complete penetrance0.00005972Highly InformativeDirect
Mammalian Phenotype (MP)decreased sensory neuron number0.0002031Highly InformativeDirect
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.00044Highly InformativeDirect
Mammalian Phenotype (MP)infertility0.002003Highly InformativeInherited
Mammalian Phenotype (MP)abnormal male reproductive system physiology0.0025Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.005325Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.01112Least InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.0000992Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.001853Moderately InformativeInherited
Worm Phenotype (WP)directionality variant0.0000009923InformativeDirect
Worm Phenotype (WP)vulva development variant0.00000256InformativeDirect
Worm Phenotype (WP)cell fate specification variant0.00000976InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect
Fly Phenotype (FP)wild-type0InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)germ cell0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)gamete0InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a E2F-DP heterodimerization region domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the E2F-DP heterodimerization region superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.