SUPERFAMILY 1.75 HMM library and genome assignments server

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DIX domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   Ubiquitin-like [ 54236] (8)
Family:   DIX domain [ 159926]

Family statistics
Genomes (64) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 163 441 2
Proteins 163 441 2

Disease Ontology (DO)

show details) Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the face0.1945Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the dentition0.007745InformativeInherited
Phenotypic Abnormality (PA)Reduced number of teeth0.0001855Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.004061Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.01376Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1452Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.000013Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.0001256Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.0001411Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal embryo morphology0.0001884Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal heart morphology0.0002302Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.0002408Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal brain morphology0.0005932Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal head morphology0.0006373Moderately InformativeDirect
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.0009425Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.004636Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.4608Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.000002413InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.00003932InformativeDirect
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.02479InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.04506InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.07131InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.2736InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.0000002156Highly InformativeDirect
Mammalian Phenotype (MP)abnormal orientation of cochlear hair cell stereociliary bundles0.0000003304Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell number0.000001163Highly InformativeDirect
Mammalian Phenotype (MP)increased sensory neuron number0.000001254Highly InformativeDirect
Mammalian Phenotype (MP)persistent truncus arteriosis0.000006073Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tail morphology0.00001909Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rostral-caudal axis patterning0.0000219Highly InformativeDirect
Mammalian Phenotype (MP)double outlet right ventricle0.00002264Highly InformativeDirect
Mammalian Phenotype (MP)craniorachischisis0.0001193Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology0.4147Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 160 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Ubiquitin-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]