BRK domain-like superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: GYF/BRK domain-like [ 55276] (2)
• Superfamily: BRK domain-like [ 160481]
• Families: BRK domain-like [ 160482] (2)

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Superfamily statistics

	Genomes (149)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	907	2,953	5
Proteins	739	2,464	5

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Functional annotation

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	DNA helicase	0	1.162	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.04271	--	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0	0.6408	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides; involved in cellular an	0	0.8971	Moderately Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal dominant inheritance	0	0.5798	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of body height	0	1.452	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.472	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skull size	0	1.26	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the face	0	0.5614	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the orbital region	0	1.176	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2543	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0	0.4621	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the foot	0	1.106	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0	0.7344	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the ocular adnexa	0	1.176	--	DIRECT
Phenotypic Abnormality (PA)	Sparse hair	0.000359	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of hair density	0.0004015	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving bones of the lower limbs	0.0004752	1.708	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal maturation	0.0006223	2.106	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of mouth size	0.0006305	1.804	--	DIRECT
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving bones of the extremities	0.003151	1.561	--	INHERITED FROM: Aplasia/hypoplasia involving bones of the lower limbs
Phenotypic Abnormality (PA)	Abnormal hair morphology	0.02001	1.26	--	INHERITED FROM: Sparse hair || Abnormality of hair density
Phenotypic Abnormality (PA)	Abnormality of the hand	0.03367	1.064	--	INHERITED FROM: Abnormality of the palm
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving the skeleton	0.07811	1.293	--	INHERITED FROM: Aplasia/hypoplasia involving bones of the lower limbs
Phenotypic Abnormality (PA)	Abnormal oral morphology	0.09158	0.8625	--	INHERITED FROM: Abnormality of mouth size
Phenotypic Abnormality (PA)	Abnormality of limb bone	0.147	0.9441	--	INHERITED FROM: Aplasia/hypoplasia involving bones of the lower limbs
Phenotypic Abnormality (PA)	Abnormal appendicular skeleton morphology	0.2192	0.8625	--	INHERITED FROM: Aplasia/hypoplasia involving bones of the lower limbs
Phenotypic Abnormality (PA)	Abnormality of the mouth	0.4863	0.8383	--	INHERITED FROM: Abnormality of mouth size
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4771	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	0.472	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.4022	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of limbs	0	0.6431	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the integument	0.1721	0.7253	Least Informative	INHERITED FROM: Abnormality of hair density || Sparse hair
Phenotypic Abnormality (PA)	Abnormal skull morphology	0	1.009	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Growth abnormality	0	0.9441	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0	0.9152	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0	0.8268	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Neurodevelopmental abnormality	0	0.8502	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal ocular adnexa morphology	0	1.176	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skin adnexa morphology	0.02906	1.202	Moderately Informative	INHERITED FROM: Abnormality of hair density || Sparse hair
Phenotypic Abnormality (PA)	Abnormality of limb bone morphology	0.04332	0.9441	Moderately Informative	INHERITED FROM: Aplasia/hypoplasia involving bones of the lower limbs
Phenotypic Abnormality (PA)	Abnormality of skeletal physiology	0.1541	1.176	Moderately Informative	INHERITED FROM: Delayed skeletal maturation || Abnormality of skeletal maturation
Phenotypic Abnormality (PA)	Abnormality of the upper limb	0.4159	0.9441	Moderately Informative	INHERITED FROM: Abnormality of the palm
Phenotypic Abnormality (PA)	Abnormal oral cavity morphology	1	0.9594	Moderately Informative	INHERITED FROM: Abnormality of mouth size
Phenotypic Abnormality (PA)	Abnormality of the nose	0	1.327	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal eyelid morphology	0	1.407	Informative	DIRECT
Phenotypic Abnormality (PA)	Intellectual disability	0	1.365	Informative	DIRECT
Phenotypic Abnormality (PA)	Seizures	0	1.327	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the palm	0.0005405	1.628	Informative	DIRECT
Phenotypic Abnormality (PA)	Aplasia/hypoplasia of the extremities	0.04414	1.503	Informative	INHERITED FROM: Aplasia/hypoplasia involving bones of the lower limbs
Phenotypic Abnormality (PA)	Abnormal lower limb bone morphology	0.06211	1.365	Informative	INHERITED FROM: Aplasia/hypoplasia involving bones of the lower limbs
Phenotypic Abnormality (PA)	Delayed skeletal maturation	0.00044	2.106	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	brain	0	1.161	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	visual system	0	1.485	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.2245	--	DIRECT
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5472	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1889	--	DIRECT
Zebrafish Anatomy (ZA)	electrically active cell	0	1.263	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: cell || digestive system || brain || anatomical system || multi-tissue structure || eye || sensory system || anatomical group || whole organism || visual system || electrically active cell || organism subdivision || compound organ || central nervous system || cavitated compound organ || head || nervous system
Zebrafish Anatomy (ZA)	nervous system	0	0.6911	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	compound organ	0	0.4571	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	organism subdivision	0	0.6264	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	multi-tissue structure	0	0.6005	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	cell	0	0.7491	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	central nervous system	0	1.008	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	sensory system	0	1.097	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	head	0	1.008	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	eye	0	1.485	Informative	DIRECT
Zebrafish Anatomy (ZA)	digestive system	0	1.74	Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.5108	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.4287	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0	0.5909	--	DIRECT
Xenopus ANatomical entity (XAN)	male genitalia	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0	0.6506	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1442	--	DIRECT
Xenopus ANatomical entity (XAN)	male organism	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1871	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.24	--	DIRECT
Xenopus ANatomical entity (XAN)	gonad	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.193	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	otic vesicle	0.000579	1.647	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.3094	--	INHERITED FROM: testis || hindbrain || urogenital system || nervous system || forebrain || brain || genital system || vestibuloauditory system || midbrain || male genitalia || central nervous system || otic vesicle
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: urogenital system || head region || genital system || brain || forebrain || nervous system || hindbrain || anatomical group || testis || cavitated compound organ || multicellular anatomical structure || gonad || compound organ || trunk || tissue || anatomical region || otic vesicle || central nervous system || male genitalia || trunk region || male organism || midbrain || vestibuloauditory system || organism subdivision || head
Xenopus ANatomical entity (XAN)	urogenital system	0	0.5011	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	nervous system	0	0.6341	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.5108	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.4308	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.5011	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.3033	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	brain	0	0.8635	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	testis	0	0.8318	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	sensory system	0.005864	1.17	Moderately Informative	INHERITED FROM: vestibuloauditory system || otic vesicle
Xenopus ANatomical entity (XAN)	multi-tissue structure	0.007496	1.071	Moderately Informative	INHERITED FROM: forebrain || hindbrain || midbrain
Xenopus ANatomical entity (XAN)	vestibuloauditory system	0.0001327	1.531	Informative	DIRECT
Xenopus ANatomical entity (XAN)	forebrain	0.0005119	1.682	Informative	DIRECT
Xenopus ANatomical entity (XAN)	midbrain	0.0003158	1.807	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	hindbrain	0.0004706	1.761	Highly Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acting on ATP; involved in cellular and subcellular movement	0	1.196	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.3541	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0	0.9562	Moderately Informative	DIRECT
Enzyme Commission (EC)	DNA helicase	0	1.475	Informative	DIRECT

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