SUPERFAMILY 1.75 HMM library and genome assignments server

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SNF-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   SNF-like [ 161069]
Superfamily:   SNF-like [ 161070]
Families:   SNF-like [ 161071]

Superfamily statistics
Genomes (1,279) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 6,165 30,023 2
Proteins 5,880 29,479 2

Functional annotation
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.003876Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.00008742InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.1066InformativeInherited
Disease Ontology (DO)bipolar disorder0.0001191Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.04282Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.04554Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1823Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal amino acid level0.0000417InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.00009126InformativeDirect
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.0006325InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.004334InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.02139InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.0001025Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.0001858Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.1252Least InformativeInherited
Worm Phenotype (WP)movement variant0.00000104Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.000005599Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.00000579Moderately InformativeDirect
Worm Phenotype (WP)drug response variant0.01537Moderately InformativeInherited
Worm Phenotype (WP)body posture variant0InformativeDirect
Worm Phenotype (WP)localized movement variant0InformativeDirect
Worm Phenotype (WP)body bend variant4.49e-16InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.00000000000001877InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.00000492InformativeDirect
Worm Phenotype (WP)drug hypersensitive0.0001049InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.0001903InformativeDirect
Worm Phenotype (WP)directionality variant0.00637InformativeInherited
Worm Phenotype (WP)small0.5963InformativeInherited
Worm Phenotype (WP)locomotion reduced1InformativeInherited
Worm Phenotype (WP)coiling frequency variant0.00000000000001565Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.00000000000004375Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.00000000000006244Highly InformativeDirect
Worm Phenotype (WP)fat0.0000003172Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.0000003378Highly InformativeDirect
Worm Phenotype (WP)short0.000004875Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.008209Highly InformativeInherited
Worm Phenotype (WP)foraging hyperactive0.02039Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a SNF-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the SNF-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Internal database links ]