SNF-like superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Membrane and cell surface proteins and peptides [ 56835] (58)
• Fold: SNF-like [ 161069]
• Superfamily: SNF-like [ 161070]
• Families: SNF-like [ 161071]

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Superfamily statistics

	Genomes (1,279)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	6,165	30,023	2
Proteins	5,880	29,479	2

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Functional annotation

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	specific developmental disorder	0.0005297	1.769	--	DIRECT
Disease Ontology (DO)	drug dependence	0.0008259	1.894	--	DIRECT
Disease Ontology (DO)	mood disorder	0.004038	1.769	--	INHERITED FROM: bipolar disorder
Disease Ontology (DO)	substance-related disorder	0.007284	1.593	--	INHERITED FROM: substance dependence || drug dependence
Disease Ontology (DO)	cognitive disorder	0.3921	1.092	--	INHERITED FROM: bipolar disorder
Disease Ontology (DO)	disease of mental health	0.003876	1.009	Moderately Informative	INHERITED FROM: bipolar disorder || specific developmental disorder || substance dependence || drug dependence
Disease Ontology (DO)	substance dependence	0.00008742	1.593	Informative	DIRECT
Disease Ontology (DO)	developmental disorder of mental health	0.1066	1.468	Informative	INHERITED FROM: specific developmental disorder
Disease Ontology (DO)	bipolar disorder	0.0001191	1.769	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2543	--	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal response to novel object	0.00000256	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal sensorimotor gating	0.00002091	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal synaptic transmission	0.01356	1.146	--	INHERITED FROM: abnormal CNS synaptic transmission
Mammalian Phenotype (MP)	abnormal cognition	0.02987	1.394	--	INHERITED FROM: abnormal associative learning
Mammalian Phenotype (MP)	behavior/neurological phenotype	0.03722	0.9281	--	INHERITED FROM: abnormal associative learning || abnormal behavioral response to xenobiotic || abnormal response to novel object
Mammalian Phenotype (MP)	abnormal response to novelty	0.09072	1.906	--	INHERITED FROM: abnormal response to novel object
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.0971	0.3617	--	INHERITED FROM: abnormal amino acid level
Mammalian Phenotype (MP)	nervous system phenotype	0.04282	0.5166	Least Informative	INHERITED FROM: abnormal sensorimotor gating || abnormal CNS synaptic transmission
Mammalian Phenotype (MP)	abnormal homeostasis	0.04554	0.495	Least Informative	INHERITED FROM: abnormal amino acid level
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.1823	0.8744	Moderately Informative	INHERITED FROM: abnormal CNS synaptic transmission || abnormal sensorimotor gating
Mammalian Phenotype (MP)	abnormal behavior	1	0.9397	Moderately Informative	INHERITED FROM: abnormal behavioral response to xenobiotic || abnormal associative learning || abnormal response to novel object
Mammalian Phenotype (MP)	abnormal amino acid level	0.0000417	1.605	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal behavioral response to xenobiotic	0.00009126	1.605	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal CNS synaptic transmission	0.0006325	1.253	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal learning/memory/conditioning	0.004334	1.394	Informative	INHERITED FROM: abnormal associative learning
Mammalian Phenotype (MP)	abnormal emotion/affect behavior	0.02139	1.554	Informative	INHERITED FROM: abnormal response to novel object
Mammalian Phenotype (MP)	abnormal associative learning	0.0001025	1.809	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	head movement variant	0	1.628	--	DIRECT
Worm Phenotype (WP)	head bend angle variant	0	1.628	--	DIRECT
Worm Phenotype (WP)	coiling frequency decreased	0	2.708	--	DIRECT
Worm Phenotype (WP)	nose movement variant	0	1.708	--	DIRECT
Worm Phenotype (WP)	sinusoidal movement variant	4.49e-16	1.708	--	DIRECT
Worm Phenotype (WP)	turning frequency variant	0.00000000000007044	1.628	--	DIRECT
Worm Phenotype (WP)	locomotor coordination variant	0.00000000000009268	1.452	--	DIRECT
Worm Phenotype (WP)	roaming increased	0.0000000001337	2.407	--	DIRECT
Worm Phenotype (WP)	backward locomotion variant	0.00000000116	1.666	--	DIRECT
Worm Phenotype (WP)	body width variant	0.0000002086	1.245	--	DIRECT
Worm Phenotype (WP)	body size variant	0.0000005937	1.202	--	DIRECT
Worm Phenotype (WP)	locomotion variant	0.0000007901	1.045	--	DIRECT
Worm Phenotype (WP)	body morphology variant	0.000001284	1.164	--	DIRECT
Worm Phenotype (WP)	activity level variant	0.00001572	1.346	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.0002005	0.632	--	DIRECT
Worm Phenotype (WP)	turning variant	0.1488	1.628	--	INHERITED FROM: turning frequency variant
Worm Phenotype (WP)	coiling variant	0.2349	1.804	--	INHERITED FROM: coiling frequency decreased || coiling frequency variant
Worm Phenotype (WP)	chemical response variant	0.2791	0.8045	--	INHERITED FROM: drug hypersensitive
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.8388	0.1501	--	INHERITED FROM: drug hypersensitive
Worm Phenotype (WP)	organism physiology variant	0.8568	0.1405	--	INHERITED FROM: drug hypersensitive
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: roaming increased || localized movement variant || activity level variant || turning frequency variant || drug hypersensitive || nose movement variant || body bend variant || sinusoidal movement variant || body posture variant || head bend angle variant || movement variant || pausing variant || forward locomotion variant || coiling frequency variant || backward point velocity variant || backward locomotion variant || head movement variant || behavior variant || locomotor coordination variant || organism behavior variant || velocity of movement variant || foraging behavior variant || locomotion variant || forward point velocity variant || coiling frequency decreased
Worm Phenotype (WP)	body length variant	1	1.346	--	INHERITED FROM: short
Worm Phenotype (WP)	reversal variant	1	1.561	--	INHERITED FROM: backward locomotion variant
Worm Phenotype (WP)	organism behavior variant	0.0001858	0.632	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0.1252	0.5677	Least Informative	INHERITED FROM: drug hypersensitive
Worm Phenotype (WP)	movement variant	0.00000104	1.026	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism segment morphology variant	0.000005599	1.064	Moderately Informative	DIRECT
Worm Phenotype (WP)	body region morphology variant	0.00000579	1.045	Moderately Informative	DIRECT
Worm Phenotype (WP)	drug response variant	0.01537	1.017	Moderately Informative	INHERITED FROM: drug hypersensitive
Worm Phenotype (WP)	body posture variant	0	1.531	Informative	DIRECT
Worm Phenotype (WP)	localized movement variant	0	1.594	Informative	DIRECT
Worm Phenotype (WP)	body bend variant	4.49e-16	1.708	Informative	DIRECT
Worm Phenotype (WP)	foraging behavior variant	0.00000000000001877	1.594	Informative	DIRECT
Worm Phenotype (WP)	forward locomotion variant	0.00000492	1.628	Informative	DIRECT
Worm Phenotype (WP)	drug hypersensitive	0.0001049	1.708	Informative	DIRECT
Worm Phenotype (WP)	velocity of movement variant	0.0001903	1.708	Informative	DIRECT
Worm Phenotype (WP)	directionality variant	0.00637	1.531	Informative	INHERITED FROM: backward locomotion variant || turning frequency variant
Worm Phenotype (WP)	small	0.5963	1.594	Informative	INHERITED FROM: short
Worm Phenotype (WP)	locomotion reduced	1	1.452	Informative	INHERITED FROM: pausing variant
Worm Phenotype (WP)	coiling frequency variant	0.00000000000001565	1.804	Highly Informative	DIRECT
Worm Phenotype (WP)	forward point velocity variant	0.00000000000004375	2.009	Highly Informative	DIRECT
Worm Phenotype (WP)	backward point velocity variant	0.00000000000006244	1.862	Highly Informative	DIRECT
Worm Phenotype (WP)	fat	0.0000003172	2.009	Highly Informative	DIRECT
Worm Phenotype (WP)	pausing variant	0.0000003378	2.009	Highly Informative	DIRECT
Worm Phenotype (WP)	short	0.000004875	1.804	Highly Informative	DIRECT
Worm Phenotype (WP)	roaming variant	0.008209	1.862	Highly Informative	INHERITED FROM: roaming increased
Worm Phenotype (WP)	foraging hyperactive	0.02039	2.009	Highly Informative	INHERITED FROM: roaming increased

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.07918	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.009143	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure || organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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